-- dump date   	20140619_020932
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
1170562000001	DDE superfamily endonuclease; Region: DDE_3; pfam13358
1170562000002	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
1170562000003	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1170562000004	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1170562000005	catalytic residues [active]
1170562000006	catalytic nucleophile [active]
1170562000007	Presynaptic Site I dimer interface [polypeptide binding]; other site
1170562000008	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1170562000009	Synaptic Flat tetramer interface [polypeptide binding]; other site
1170562000010	Synaptic Site I dimer interface [polypeptide binding]; other site
1170562000011	DNA binding site [nucleotide binding]
1170562000012	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
1170562000013	DNA-binding interface [nucleotide binding]; DNA binding site
1170562000014	Integrase core domain; Region: rve; pfam00665
1170562000015	Integrase core domain; Region: rve_3; cl15866
1170562000016	Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267
1170562000017	Homeodomain-like domain; Region: HTH_23; pfam13384
1170562000018	Winged helix-turn helix; Region: HTH_29; pfam13551
1170562000019	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1170562000020	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1170562000021	P-loop; other site
1170562000022	Magnesium ion binding site [ion binding]; other site
1170562000023	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1170562000024	Magnesium ion binding site [ion binding]; other site
1170562000025	ParB-like nuclease domain; Region: ParBc; pfam02195
1170562000026	KilA-N domain; Region: KilA-N; pfam04383
1170562000027	ParB-like nuclease domain; Region: ParBc; pfam02195
1170562000028	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1170562000029	ATP binding site [chemical binding]; other site
1170562000030	putative Mg++ binding site [ion binding]; other site
1170562000031	nucleotide binding region [chemical binding]; other site
1170562000032	helicase superfamily c-terminal domain; Region: HELICc; smart00490
1170562000033	ATP-binding site [chemical binding]; other site
1170562000034	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
1170562000035	Mg binding site [ion binding]; other site
1170562000036	nucleotide binding site [chemical binding]; other site
1170562000037	putative protofilament interface [polypeptide binding]; other site
1170562000038	Bacterial mobilisation protein (MobC); Region: MobC; pfam05713
1170562000039	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
1170562000040	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
1170562000041	Domain of unknown function (DUF3854); Region: DUF3854; pfam12965
1170562000042	D5 N terminal like; Region: D5_N; pfam08706
1170562000043	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
1170562000044	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
1170562000045	Mg binding site [ion binding]; other site
1170562000046	nucleotide binding site [chemical binding]; other site
1170562000047	putative protofilament interface [polypeptide binding]; other site
1170562000048	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
1170562000049	McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737
1170562000050	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1170562000051	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1170562000052	Walker A motif; other site
1170562000053	ATP binding site [chemical binding]; other site
1170562000054	Walker B motif; other site
1170562000055	arginine finger; other site
1170562000056	Uncharacterized conserved protein [Function unknown]; Region: COG4933
1170562000057	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1170562000058	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1170562000059	Coenzyme A binding pocket [chemical binding]; other site
1170562000060	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257
1170562000061	GIY-YIG motif/motif A; other site
1170562000062	active site
1170562000063	catalytic site [active]
1170562000064	metal binding site [ion binding]; metal-binding site
1170562000065	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
1170562000066	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
1170562000067	cofactor binding site; other site
1170562000068	DNA binding site [nucleotide binding]
1170562000069	substrate interaction site [chemical binding]; other site
1170562000070	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
1170562000071	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1170562000072	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
1170562000073	active site
1170562000074	DNA binding site [nucleotide binding]
1170562000075	Int/Topo IB signature motif; other site
1170562000076	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1170562000077	CHAP domain; Region: CHAP; cl17642
1170562000078	Protein of unknown function (DUF3376); Region: DUF3376; pfam11856
1170562000079	choline dehydrogenase; Validated; Region: PRK02106
1170562000080	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1170562000081	alpha-dioxygenase; Region: PLN02283
1170562000082	Animal heme oxidases similar to plant pathogen-inducible oxygenases; Region: PIOX_like; cd09818
1170562000083	putative heme binding site [chemical binding]; other site
1170562000084	putative active site [active]
1170562000085	putative substrate binding site [chemical binding]; other site
1170562000086	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1170562000087	Helix-turn-helix domain; Region: HTH_18; pfam12833
1170562000088	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1170562000089	bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882
1170562000090	YcaO-like family; Region: YcaO; pfam02624
1170562000091	thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604
1170562000092	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
1170562000093	Transposase [DNA replication, recombination, and repair]; Region: COG5421
1170562000094	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
1170562000095	Leucine carboxyl methyltransferase; Region: LCM; cl01306
1170562000096	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
1170562000097	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1170562000098	FeS/SAM binding site; other site
1170562000099	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
1170562000100	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
1170562000101	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1170562000102	active site
1170562000103	ATP binding site [chemical binding]; other site
1170562000104	substrate binding site [chemical binding]; other site
1170562000105	activation loop (A-loop); other site
1170562000106	AAA ATPase domain; Region: AAA_16; pfam13191
1170562000107	Predicted ATPase [General function prediction only]; Region: COG3899
1170562000108	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1170562000109	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1170562000110	PAS fold; Region: PAS_4; pfam08448
1170562000111	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562000112	putative active site [active]
1170562000113	heme pocket [chemical binding]; other site
1170562000114	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
1170562000115	G1 box; other site
1170562000116	GTP/Mg2+ binding site [chemical binding]; other site
1170562000117	G2 box; other site
1170562000118	Switch I region; other site
1170562000119	G3 box; other site
1170562000120	Switch II region; other site
1170562000121	G4 box; other site
1170562000122	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
1170562000123	stage V sporulation protein K; Region: spore_V_K; TIGR02881
1170562000124	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1170562000125	Walker A motif; other site
1170562000126	ATP binding site [chemical binding]; other site
1170562000127	Walker B motif; other site
1170562000128	arginine finger; other site
1170562000129	stage V sporulation protein K; Region: spore_V_K; TIGR02881
1170562000130	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1170562000131	Walker A motif; other site
1170562000132	ATP binding site [chemical binding]; other site
1170562000133	Walker B motif; other site
1170562000134	arginine finger; other site
1170562000135	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
1170562000136	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
1170562000137	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
1170562000138	NB-ARC domain; Region: NB-ARC; pfam00931
1170562000139	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562000140	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562000141	binding surface
1170562000142	TPR motif; other site
1170562000143	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562000144	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562000145	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562000146	binding surface
1170562000147	TPR motif; other site
1170562000148	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562000149	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562000150	TPR motif; other site
1170562000151	binding surface
1170562000152	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562000153	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562000154	binding surface
1170562000155	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562000156	TPR motif; other site
1170562000157	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562000158	binding surface
1170562000159	TPR motif; other site
1170562000160	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562000161	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1170562000162	nucleotide binding site [chemical binding]; other site
1170562000163	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
1170562000164	ParB-like nuclease domain; Region: ParBc; pfam02195
1170562000165	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1170562000166	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1170562000167	P-loop; other site
1170562000168	Magnesium ion binding site [ion binding]; other site
1170562000169	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1170562000170	Magnesium ion binding site [ion binding]; other site
1170562000171	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1170562000172	Dynamin family; Region: Dynamin_N; pfam00350
1170562000173	G1 box; other site
1170562000174	GTP/Mg2+ binding site [chemical binding]; other site
1170562000175	G2 box; other site
1170562000176	Switch I region; other site
1170562000177	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1170562000178	G3 box; other site
1170562000179	Switch II region; other site
1170562000180	G4 box; other site
1170562000181	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
1170562000182	metal ion-dependent adhesion site (MIDAS); other site
1170562000183	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1170562000184	active site
1170562000185	catalytic residues [active]
1170562000186	DNA binding site [nucleotide binding]
1170562000187	Int/Topo IB signature motif; other site
1170562000188	Helix-turn-helix; Region: HTH_3; pfam01381
1170562000189	non-specific DNA binding site [nucleotide binding]; other site
1170562000190	salt bridge; other site
1170562000191	sequence-specific DNA binding site [nucleotide binding]; other site
1170562000192	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1170562000193	non-specific DNA binding site [nucleotide binding]; other site
1170562000194	salt bridge; other site
1170562000195	sequence-specific DNA binding site [nucleotide binding]; other site
1170562000196	Predicted membrane protein [Function unknown]; Region: COG5373
1170562000197	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
1170562000198	Bacterial mobilisation protein (MobC); Region: MobC; pfam05713
1170562000199	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
1170562000200	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1170562000201	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1170562000202	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562000203	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562000204	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562000205	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
1170562000206	multiple promoter invertase; Provisional; Region: mpi; PRK13413
1170562000207	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1170562000208	catalytic residues [active]
1170562000209	catalytic nucleophile [active]
1170562000210	Presynaptic Site I dimer interface [polypeptide binding]; other site
1170562000211	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1170562000212	Synaptic Flat tetramer interface [polypeptide binding]; other site
1170562000213	Synaptic Site I dimer interface [polypeptide binding]; other site
1170562000214	DNA binding site [nucleotide binding]
1170562000215	Helix-turn-helix domain; Region: HTH_38; pfam13936
1170562000216	Integrase core domain; Region: rve; pfam00665
1170562000217	Integrase core domain; Region: rve_3; cl15866
1170562000218	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
1170562000219	DnaA N-terminal domain; Region: DnaA_N; pfam11638
1170562000220	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1170562000221	Walker A motif; other site
1170562000222	ATP binding site [chemical binding]; other site
1170562000223	Walker B motif; other site
1170562000224	arginine finger; other site
1170562000225	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
1170562000226	DnaA box-binding interface [nucleotide binding]; other site
1170562000227	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
1170562000228	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1170562000229	dimer interface [polypeptide binding]; other site
1170562000230	putative functional site; other site
1170562000231	putative MPT binding site; other site
1170562000232	RDD family; Region: RDD; pfam06271
1170562000233	ribosomal protein L33; Region: rpl33; CHL00104
1170562000234	ribosomal protein S18; Region: rps18; CHL00077
1170562000235	Exoribonuclease R [Transcription]; Region: VacB; COG0557
1170562000236	RNB domain; Region: RNB; pfam00773
1170562000237	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1170562000238	Protein of unknown function (DUF3318); Region: DUF3318; pfam11780
1170562000239	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
1170562000240	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1170562000241	FeS/SAM binding site; other site
1170562000242	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1170562000243	anti sigma factor interaction site; other site
1170562000244	regulatory phosphorylation site [posttranslational modification]; other site
1170562000245	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1170562000246	putative glycosyl transferase; Provisional; Region: PRK10307
1170562000247	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
1170562000248	Oligomerisation domain; Region: Oligomerisation; pfam02410
1170562000249	Protein of unknown function (DUF1230); Region: DUF1230; pfam06799
1170562000250	L-asparaginase II; Region: Asparaginase_II; cl01842
1170562000251	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1170562000252	Switch II region; other site
1170562000253	G4 box; other site
1170562000254	G5 box; other site
1170562000255	Domain of unknown function (DUF697); Region: DUF697; pfam05128
1170562000256	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
1170562000257	intersubunit interface [polypeptide binding]; other site
1170562000258	active site
1170562000259	catalytic residue [active]
1170562000260	Recombination protein O N terminal; Region: RecO_N; pfam11967
1170562000261	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
1170562000262	Recombination protein O C terminal; Region: RecO_C; pfam02565
1170562000263	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1170562000264	H+ Antiporter protein; Region: 2A0121; TIGR00900
1170562000265	putative substrate translocation pore; other site
1170562000266	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1170562000267	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1170562000268	YqaJ-like viral recombinase domain; Region: YqaJ; cl09232
1170562000269	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1170562000270	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1170562000271	active site
1170562000272	ATP binding site [chemical binding]; other site
1170562000273	substrate binding site [chemical binding]; other site
1170562000274	activation loop (A-loop); other site
1170562000275	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
1170562000276	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344
1170562000277	putative ligand binding site [chemical binding]; other site
1170562000278	M28 Zn-Peptidases; Region: M28_like_1; cd05640
1170562000279	Peptidase family M28; Region: Peptidase_M28; pfam04389
1170562000280	metal binding site [ion binding]; metal-binding site
1170562000281	Uncharacterized conserved protein [Function unknown]; Region: COG2836
1170562000282	Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043
1170562000283	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1170562000284	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
1170562000285	catalytic triad [active]
1170562000286	Protein of unknown function (DUF3148); Region: DUF3148; pfam11347
1170562000287	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
1170562000288	dimer interface [polypeptide binding]; other site
1170562000289	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1170562000290	Histidine kinase; Region: HisKA_3; pfam07730
1170562000291	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562000292	ATP binding site [chemical binding]; other site
1170562000293	Mg2+ binding site [ion binding]; other site
1170562000294	G-X-G motif; other site
1170562000295	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1170562000296	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562000297	active site
1170562000298	phosphorylation site [posttranslational modification]
1170562000299	intermolecular recognition site; other site
1170562000300	dimerization interface [polypeptide binding]; other site
1170562000301	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1170562000302	DNA binding residues [nucleotide binding]
1170562000303	dimerization interface [polypeptide binding]; other site
1170562000304	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1170562000305	nucleoside/Zn binding site; other site
1170562000306	dimer interface [polypeptide binding]; other site
1170562000307	catalytic motif [active]
1170562000308	Ion transport protein; Region: Ion_trans; pfam00520
1170562000309	Ion channel; Region: Ion_trans_2; pfam07885
1170562000310	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1170562000311	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1170562000312	Walker A/P-loop; other site
1170562000313	ATP binding site [chemical binding]; other site
1170562000314	Q-loop/lid; other site
1170562000315	ABC transporter signature motif; other site
1170562000316	Walker B; other site
1170562000317	D-loop; other site
1170562000318	H-loop/switch region; other site
1170562000319	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1170562000320	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1170562000321	Walker A/P-loop; other site
1170562000322	ATP binding site [chemical binding]; other site
1170562000323	Q-loop/lid; other site
1170562000324	ABC transporter signature motif; other site
1170562000325	Walker B; other site
1170562000326	D-loop; other site
1170562000327	H-loop/switch region; other site
1170562000328	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1170562000329	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
1170562000330	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1170562000331	dimerization interface [polypeptide binding]; other site
1170562000332	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1170562000333	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1170562000334	active site
1170562000335	ATP binding site [chemical binding]; other site
1170562000336	substrate binding site [chemical binding]; other site
1170562000337	activation loop (A-loop); other site
1170562000338	FOG: WD40 repeat [General function prediction only]; Region: COG2319
1170562000339	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
1170562000340	structural tetrad; other site
1170562000341	Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972
1170562000342	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
1170562000343	active site
1170562000344	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
1170562000345	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1170562000346	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1170562000347	ribosome maturation protein RimP; Reviewed; Region: PRK00092
1170562000348	Sm and related proteins; Region: Sm_like; cl00259
1170562000349	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
1170562000350	putative oligomer interface [polypeptide binding]; other site
1170562000351	putative RNA binding site [nucleotide binding]; other site
1170562000352	NusA N-terminal domain; Region: NusA_N; pfam08529
1170562000353	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
1170562000354	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
1170562000355	RNA binding site [nucleotide binding]; other site
1170562000356	homodimer interface [polypeptide binding]; other site
1170562000357	NusA-like KH domain; Region: KH_5; pfam13184
1170562000358	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1170562000359	G-X-X-G motif; other site
1170562000360	Protein of unknown function (DUF448); Region: DUF448; pfam04296
1170562000361	putative RNA binding cleft [nucleotide binding]; other site
1170562000362	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1170562000363	translation initiation factor IF-2; Validated; Region: infB; PRK05306
1170562000364	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1170562000365	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
1170562000366	G1 box; other site
1170562000367	putative GEF interaction site [polypeptide binding]; other site
1170562000368	GTP/Mg2+ binding site [chemical binding]; other site
1170562000369	Switch I region; other site
1170562000370	G2 box; other site
1170562000371	G3 box; other site
1170562000372	Switch II region; other site
1170562000373	G4 box; other site
1170562000374	G5 box; other site
1170562000375	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
1170562000376	Translation-initiation factor 2; Region: IF-2; pfam11987
1170562000377	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
1170562000378	putative phosphoketolase; Provisional; Region: PRK05261
1170562000379	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
1170562000380	TPP-binding site; other site
1170562000381	XFP C-terminal domain; Region: XFP_C; pfam09363
1170562000382	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1170562000383	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1170562000384	ligand binding site [chemical binding]; other site
1170562000385	flexible hinge region; other site
1170562000386	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
1170562000387	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1170562000388	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1170562000389	active site
1170562000390	metal binding site [ion binding]; metal-binding site
1170562000391	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
1170562000392	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
1170562000393	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
1170562000394	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
1170562000395	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
1170562000396	Tetramer interface [polypeptide binding]; other site
1170562000397	active site
1170562000398	FMN-binding site [chemical binding]; other site
1170562000399	Uncharacterized conserved protein [Function unknown]; Region: COG4095
1170562000400	Predicted membrane protein [Function unknown]; Region: COG4244
1170562000401	Predicted membrane protein [Function unknown]; Region: COG4244
1170562000402	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
1170562000403	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
1170562000404	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
1170562000405	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
1170562000406	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
1170562000407	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
1170562000408	Subunit I/III interface [polypeptide binding]; other site
1170562000409	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
1170562000410	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
1170562000411	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
1170562000412	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
1170562000413	coproporphyrinogen III oxidase; Provisional; Region: PRK07379
1170562000414	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1170562000415	FeS/SAM binding site; other site
1170562000416	HemN C-terminal domain; Region: HemN_C; pfam06969
1170562000417	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
1170562000418	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
1170562000419	putative active site [active]
1170562000420	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
1170562000421	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1170562000422	catalytic loop [active]
1170562000423	iron binding site [ion binding]; other site
1170562000424	cobyric acid synthase; Provisional; Region: PRK00784
1170562000425	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1170562000426	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1170562000427	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
1170562000428	catalytic triad [active]
1170562000429	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
1170562000430	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1170562000431	active site
1170562000432	motif I; other site
1170562000433	motif II; other site
1170562000434	Iron permease FTR1 family; Region: FTR1; cl00475
1170562000435	aspartate aminotransferase; Provisional; Region: PRK05764
1170562000436	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1170562000437	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1170562000438	homodimer interface [polypeptide binding]; other site
1170562000439	catalytic residue [active]
1170562000440	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
1170562000441	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1170562000442	putative metal binding site; other site
1170562000443	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562000444	TPR motif; other site
1170562000445	binding surface
1170562000446	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562000447	binding surface
1170562000448	TPR repeat; Region: TPR_11; pfam13414
1170562000449	TPR motif; other site
1170562000450	TPR repeat; Region: TPR_11; pfam13414
1170562000451	Domain of unknown function (DUF897); Region: DUF897; pfam05982
1170562000452	proton extrusion protein PcxA; Provisional; Region: PRK02507
1170562000453	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1170562000454	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1170562000455	active site
1170562000456	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
1170562000457	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
1170562000458	GTP/Mg2+ binding site [chemical binding]; other site
1170562000459	G4 box; other site
1170562000460	G5 box; other site
1170562000461	G1 box; other site
1170562000462	Switch I region; other site
1170562000463	G2 box; other site
1170562000464	G3 box; other site
1170562000465	Switch II region; other site
1170562000466	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
1170562000467	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1170562000468	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1170562000469	active site
1170562000470	dimer interface [polypeptide binding]; other site
1170562000471	motif 1; other site
1170562000472	motif 2; other site
1170562000473	motif 3; other site
1170562000474	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
1170562000475	anticodon binding site; other site
1170562000476	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1170562000477	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
1170562000478	Probable transposase; Region: OrfB_IS605; pfam01385
1170562000479	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
1170562000480	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
1170562000481	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1170562000482	hydrophobic ligand binding site; other site
1170562000483	putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976
1170562000484	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1170562000485	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
1170562000486	Proline dehydrogenase; Region: Pro_dh; pfam01619
1170562000487	Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
1170562000488	delta-1-pyrroline-5-carboxylate dehydrogenase, group 2, putative; Region: D1pyr5carbox2; TIGR01237
1170562000489	Glutamate binding site [chemical binding]; other site
1170562000490	homodimer interface [polypeptide binding]; other site
1170562000491	NAD binding site [chemical binding]; other site
1170562000492	catalytic residues [active]
1170562000493	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1170562000494	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1170562000495	active site
1170562000496	ATP binding site [chemical binding]; other site
1170562000497	substrate binding site [chemical binding]; other site
1170562000498	activation loop (A-loop); other site
1170562000499	Uncharacterized conserved protein [Function unknown]; Region: COG1262
1170562000500	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
1170562000501	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
1170562000502	DDE superfamily endonuclease; Region: DDE_5; cl17874
1170562000503	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1170562000504	non-specific DNA binding site [nucleotide binding]; other site
1170562000505	salt bridge; other site
1170562000506	sequence-specific DNA binding site [nucleotide binding]; other site
1170562000507	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1170562000508	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1170562000509	phosphopeptide binding site; other site
1170562000510	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1170562000511	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1170562000512	active site
1170562000513	ATP binding site [chemical binding]; other site
1170562000514	substrate binding site [chemical binding]; other site
1170562000515	activation loop (A-loop); other site
1170562000516	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1170562000517	S-adenosylmethionine binding site [chemical binding]; other site
1170562000518	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1170562000519	Cysteine-rich domain; Region: CCG; pfam02754
1170562000520	Cysteine-rich domain; Region: CCG; pfam02754
1170562000521	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1170562000522	FAD binding domain; Region: FAD_binding_4; pfam01565
1170562000523	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562000524	PAS fold; Region: PAS_3; pfam08447
1170562000525	putative active site [active]
1170562000526	heme pocket [chemical binding]; other site
1170562000527	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
1170562000528	Histidine kinase; Region: HisKA_2; pfam07568
1170562000529	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562000530	ATP binding site [chemical binding]; other site
1170562000531	Mg2+ binding site [ion binding]; other site
1170562000532	G-X-G motif; other site
1170562000533	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1170562000534	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562000535	active site
1170562000536	phosphorylation site [posttranslational modification]
1170562000537	intermolecular recognition site; other site
1170562000538	dimerization interface [polypeptide binding]; other site
1170562000539	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1170562000540	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562000541	dimer interface [polypeptide binding]; other site
1170562000542	phosphorylation site [posttranslational modification]
1170562000543	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562000544	ATP binding site [chemical binding]; other site
1170562000545	Mg2+ binding site [ion binding]; other site
1170562000546	G-X-G motif; other site
1170562000547	GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522
1170562000548	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
1170562000549	Probable Catalytic site; other site
1170562000550	Uncharacterized conserved protein [Function unknown]; Region: COG0398
1170562000551	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1170562000552	mercuric reductase; Validated; Region: PRK06370
1170562000553	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1170562000554	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1170562000555	Helix-turn-helix domain; Region: HTH_17; cl17695
1170562000556	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194
1170562000557	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562000558	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562000559	binding surface
1170562000560	TPR motif; other site
1170562000561	TPR repeat; Region: TPR_11; pfam13414
1170562000562	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1170562000563	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1170562000564	substrate binding pocket [chemical binding]; other site
1170562000565	membrane-bound complex binding site; other site
1170562000566	hinge residues; other site
1170562000567	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1170562000568	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1170562000569	dimer interface [polypeptide binding]; other site
1170562000570	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1170562000571	catalytic residue [active]
1170562000572	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1170562000573	putative active site [active]
1170562000574	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1170562000575	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
1170562000576	dimer interface [polypeptide binding]; other site
1170562000577	decamer (pentamer of dimers) interface [polypeptide binding]; other site
1170562000578	catalytic triad [active]
1170562000579	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1170562000580	This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821
1170562000581	putative ADP-binding pocket [chemical binding]; other site
1170562000582	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1170562000583	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
1170562000584	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1170562000585	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1170562000586	active site
1170562000587	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1170562000588	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
1170562000589	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
1170562000590	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
1170562000591	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
1170562000592	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
1170562000593	putative homodimer interface [polypeptide binding]; other site
1170562000594	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
1170562000595	heterodimer interface [polypeptide binding]; other site
1170562000596	homodimer interface [polypeptide binding]; other site
1170562000597	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
1170562000598	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
1170562000599	23S rRNA interface [nucleotide binding]; other site
1170562000600	L7/L12 interface [polypeptide binding]; other site
1170562000601	putative thiostrepton binding site; other site
1170562000602	L25 interface [polypeptide binding]; other site
1170562000603	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
1170562000604	mRNA/rRNA interface [nucleotide binding]; other site
1170562000605	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
1170562000606	23S rRNA interface [nucleotide binding]; other site
1170562000607	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
1170562000608	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
1170562000609	peripheral dimer interface [polypeptide binding]; other site
1170562000610	core dimer interface [polypeptide binding]; other site
1170562000611	L10 interface [polypeptide binding]; other site
1170562000612	L11 interface [polypeptide binding]; other site
1170562000613	putative EF-Tu interaction site [polypeptide binding]; other site
1170562000614	putative EF-G interaction site [polypeptide binding]; other site
1170562000615	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
1170562000616	Domain of unknown function (DUF4149); Region: DUF4149; pfam13664
1170562000617	Predicted membrane protein [Function unknown]; Region: COG2119
1170562000618	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
1170562000619	ParB-like nuclease domain; Region: ParBc; cl02129
1170562000620	Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385
1170562000621	Stage II sporulation protein; Region: SpoIID; pfam08486
1170562000622	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1170562000623	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1170562000624	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1170562000625	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898
1170562000626	putative active site [active]
1170562000627	ICEA Protein; Region: ICEA; pfam05315
1170562000628	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1170562000629	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1170562000630	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1170562000631	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
1170562000632	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
1170562000633	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
1170562000634	Nucleotide binding site [chemical binding]; other site
1170562000635	DTAP/Switch II; other site
1170562000636	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
1170562000637	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
1170562000638	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
1170562000639	SLBB domain; Region: SLBB; pfam10531
1170562000640	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
1170562000641	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562000642	ATP binding site [chemical binding]; other site
1170562000643	Mg2+ binding site [ion binding]; other site
1170562000644	G-X-G motif; other site
1170562000645	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
1170562000646	ATP binding site [chemical binding]; other site
1170562000647	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
1170562000648	RDD family; Region: RDD; pfam06271
1170562000649	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
1170562000650	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562000651	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562000652	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562000653	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562000654	Transposase domain (DUF772); Region: DUF772; pfam05598
1170562000655	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1170562000656	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1170562000657	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1170562000658	Protein of unknown function (DUF2811); Region: DUF2811; pfam10929
1170562000659	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1170562000660	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562000661	active site
1170562000662	phosphorylation site [posttranslational modification]
1170562000663	intermolecular recognition site; other site
1170562000664	dimerization interface [polypeptide binding]; other site
1170562000665	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1170562000666	DNA binding site [nucleotide binding]
1170562000667	Protein of unknown function (DUF3353); Region: DUF3353; pfam11833
1170562000668	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1170562000669	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1170562000670	motif II; other site
1170562000671	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
1170562000672	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
1170562000673	dimer interface [polypeptide binding]; other site
1170562000674	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
1170562000675	active site
1170562000676	Fe binding site [ion binding]; other site
1170562000677	NYN domain; Region: NYN; pfam01936
1170562000678	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
1170562000679	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
1170562000680	putative active site [active]
1170562000681	catalytic triad [active]
1170562000682	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
1170562000683	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1170562000684	metal binding site 2 [ion binding]; metal-binding site
1170562000685	putative DNA binding helix; other site
1170562000686	metal binding site 1 [ion binding]; metal-binding site
1170562000687	dimer interface [polypeptide binding]; other site
1170562000688	structural Zn2+ binding site [ion binding]; other site
1170562000689	Uncharacterized conserved protein [Function unknown]; Region: COG1543
1170562000690	N-terminal catalytic domain of  alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792
1170562000691	active site
1170562000692	substrate binding site [chemical binding]; other site
1170562000693	catalytic site [active]
1170562000694	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
1170562000695	The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human...; Region: tRNA_bindingDomain; cl00320
1170562000696	RNA ligase, DRB0094 family; Region: RNA_lig_DRB0094; TIGR02306
1170562000697	putative tRNA-binding site [nucleotide binding]; other site
1170562000698	RNA ligase; Region: RNA_ligase; pfam09414
1170562000699	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1170562000700	Low molecular weight phosphatase family; Region: LMWPc; cl00105
1170562000701	active site
1170562000702	ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465
1170562000703	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1170562000704	Walker A motif; other site
1170562000705	ATP binding site [chemical binding]; other site
1170562000706	Walker B motif; other site
1170562000707	arginine finger; other site
1170562000708	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
1170562000709	30S subunit binding site; other site
1170562000710	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1170562000711	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1170562000712	ATP binding site [chemical binding]; other site
1170562000713	putative Mg++ binding site [ion binding]; other site
1170562000714	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1170562000715	nucleotide binding region [chemical binding]; other site
1170562000716	ATP-binding site [chemical binding]; other site
1170562000717	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
1170562000718	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1170562000719	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1170562000720	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
1170562000721	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1170562000722	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
1170562000723	TM-ABC transporter signature motif; other site
1170562000724	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
1170562000725	putative active site [active]
1170562000726	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
1170562000727	active site
1170562000728	catalytic triad [active]
1170562000729	oxyanion hole [active]
1170562000730	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1170562000731	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
1170562000732	TM-ABC transporter signature motif; other site
1170562000733	Abortive infection C-terminus; Region: Abi_C; pfam14355
1170562000734	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
1170562000735	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1170562000736	Walker A/P-loop; other site
1170562000737	ATP binding site [chemical binding]; other site
1170562000738	Q-loop/lid; other site
1170562000739	ABC transporter signature motif; other site
1170562000740	Walker B; other site
1170562000741	D-loop; other site
1170562000742	H-loop/switch region; other site
1170562000743	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1170562000744	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
1170562000745	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
1170562000746	putative ligand binding site [chemical binding]; other site
1170562000747	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
1170562000748	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1170562000749	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1170562000750	putative active site [active]
1170562000751	CHAT domain; Region: CHAT; cl17868
1170562000752	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
1170562000753	structural tetrad; other site
1170562000754	FOG: WD40 repeat [General function prediction only]; Region: COG2319
1170562000755	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
1170562000756	structural tetrad; other site
1170562000757	WD40 repeats; Region: WD40; smart00320
1170562000758	WD40 repeats; Region: WD40; smart00320
1170562000759	domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758
1170562000760	domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758
1170562000761	Calx-beta domain; Region: Calx-beta; pfam03160
1170562000762	Domains in Na-Ca exchangers and integrin-beta4; Region: Calx_beta; smart00237
1170562000763	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
1170562000764	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
1170562000765	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
1170562000766	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
1170562000767	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1170562000768	catalytic loop [active]
1170562000769	iron binding site [ion binding]; other site
1170562000770	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
1170562000771	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
1170562000772	active site
1170562000773	catalytic residues [active]
1170562000774	metal binding site [ion binding]; metal-binding site
1170562000775	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
1170562000776	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
1170562000777	CHASE2 domain; Region: CHASE2; pfam05226
1170562000778	N-ATPase, AtpR subunit; Region: AtpR; cl11871
1170562000779	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1170562000780	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1170562000781	active site
1170562000782	ATP binding site [chemical binding]; other site
1170562000783	substrate binding site [chemical binding]; other site
1170562000784	activation loop (A-loop); other site
1170562000785	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1170562000786	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562000787	active site
1170562000788	phosphorylation site [posttranslational modification]
1170562000789	intermolecular recognition site; other site
1170562000790	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1170562000791	dimerization interface [polypeptide binding]; other site
1170562000792	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562000793	dimer interface [polypeptide binding]; other site
1170562000794	phosphorylation site [posttranslational modification]
1170562000795	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562000796	ATP binding site [chemical binding]; other site
1170562000797	Mg2+ binding site [ion binding]; other site
1170562000798	G-X-G motif; other site
1170562000799	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562000800	active site
1170562000801	phosphorylation site [posttranslational modification]
1170562000802	intermolecular recognition site; other site
1170562000803	dimerization interface [polypeptide binding]; other site
1170562000804	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1170562000805	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562000806	dimer interface [polypeptide binding]; other site
1170562000807	phosphorylation site [posttranslational modification]
1170562000808	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562000809	ATP binding site [chemical binding]; other site
1170562000810	Mg2+ binding site [ion binding]; other site
1170562000811	G-X-G motif; other site
1170562000812	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1170562000813	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562000814	active site
1170562000815	phosphorylation site [posttranslational modification]
1170562000816	intermolecular recognition site; other site
1170562000817	dimerization interface [polypeptide binding]; other site
1170562000818	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1170562000819	DNA binding residues [nucleotide binding]
1170562000820	dimerization interface [polypeptide binding]; other site
1170562000821	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1170562000822	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1170562000823	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1170562000824	Walker A/P-loop; other site
1170562000825	ATP binding site [chemical binding]; other site
1170562000826	Q-loop/lid; other site
1170562000827	ABC transporter signature motif; other site
1170562000828	Walker B; other site
1170562000829	D-loop; other site
1170562000830	H-loop/switch region; other site
1170562000831	XisH protein; Region: XisH; pfam08814
1170562000832	XisI protein; Region: XisI; pfam08869
1170562000833	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1170562000834	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1170562000835	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1170562000836	Walker A/P-loop; other site
1170562000837	ATP binding site [chemical binding]; other site
1170562000838	Q-loop/lid; other site
1170562000839	ABC transporter signature motif; other site
1170562000840	Walker B; other site
1170562000841	D-loop; other site
1170562000842	H-loop/switch region; other site
1170562000843	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1170562000844	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1170562000845	NACHT domain; Region: NACHT; pfam05729
1170562000846	HEAT repeats; Region: HEAT_2; pfam13646
1170562000847	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
1170562000848	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1170562000849	ATP binding site [chemical binding]; other site
1170562000850	Mg++ binding site [ion binding]; other site
1170562000851	motif III; other site
1170562000852	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1170562000853	nucleotide binding region [chemical binding]; other site
1170562000854	ATP-binding site [chemical binding]; other site
1170562000855	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1170562000856	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1170562000857	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562000858	dimer interface [polypeptide binding]; other site
1170562000859	phosphorylation site [posttranslational modification]
1170562000860	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562000861	ATP binding site [chemical binding]; other site
1170562000862	G-X-G motif; other site
1170562000863	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
1170562000864	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562000865	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562000866	active site
1170562000867	phosphorylation site [posttranslational modification]
1170562000868	intermolecular recognition site; other site
1170562000869	dimerization interface [polypeptide binding]; other site
1170562000870	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1170562000871	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562000872	active site
1170562000873	phosphorylation site [posttranslational modification]
1170562000874	intermolecular recognition site; other site
1170562000875	dimerization interface [polypeptide binding]; other site
1170562000876	PAS domain S-box; Region: sensory_box; TIGR00229
1170562000877	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562000878	putative active site [active]
1170562000879	heme pocket [chemical binding]; other site
1170562000880	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1170562000881	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562000882	putative active site [active]
1170562000883	heme pocket [chemical binding]; other site
1170562000884	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562000885	dimer interface [polypeptide binding]; other site
1170562000886	phosphorylation site [posttranslational modification]
1170562000887	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562000888	ATP binding site [chemical binding]; other site
1170562000889	Mg2+ binding site [ion binding]; other site
1170562000890	G-X-G motif; other site
1170562000891	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562000892	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562000893	active site
1170562000894	phosphorylation site [posttranslational modification]
1170562000895	intermolecular recognition site; other site
1170562000896	dimerization interface [polypeptide binding]; other site
1170562000897	sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472
1170562000898	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
1170562000899	putative ADP-binding pocket [chemical binding]; other site
1170562000900	sucrose phosphate synthase, sucrose phosphatase-like domain, bacterial; Region: sucr_syn_bact_C; TIGR02471
1170562000901	Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE.  NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively.  NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966
1170562000902	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
1170562000903	NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB,  and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  The protein...; Region: NifX; cd00853
1170562000904	Protein of unknown function, DUF269; Region: DUF269; pfam03270
1170562000905	Rop-like; Region: Rop-like; pfam05082
1170562000906	nitrogenase stabilizing/protective protein; Provisional; Region: nifW; PRK14102
1170562000907	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476
1170562000908	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
1170562000909	ATP binding site [chemical binding]; other site
1170562000910	substrate interface [chemical binding]; other site
1170562000911	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
1170562000912	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
1170562000913	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1170562000914	catalytic loop [active]
1170562000915	iron binding site [ion binding]; other site
1170562000916	This group of endopeptidases include HupW enzymes that are specific to the cyanobacterial hydrogenase and are involved in the C-terminal cleavage of the hydrogenase large subunit precursor protein. Cyanobacterial nickel-iron (NiFe)-hydrogenases are found...; Region: H2MP_Cyano-H2up; cd06063
1170562000917	nickel binding site [ion binding]; other site
1170562000918	tellurite resistance protein terB; Region: terB; cd07176
1170562000919	putative metal binding site [ion binding]; other site
1170562000920	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1170562000921	catalytic core [active]
1170562000922	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
1170562000923	Peptidase family M50; Region: Peptidase_M50; pfam02163
1170562000924	active site
1170562000925	putative substrate binding region [chemical binding]; other site
1170562000926	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50.  CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801
1170562000927	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1170562000928	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1170562000929	catalytic residues [active]
1170562000930	catalytic nucleophile [active]
1170562000931	Presynaptic Site I dimer interface [polypeptide binding]; other site
1170562000932	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1170562000933	Synaptic Flat tetramer interface [polypeptide binding]; other site
1170562000934	Synaptic Site I dimer interface [polypeptide binding]; other site
1170562000935	DNA binding site [nucleotide binding]
1170562000936	Recombinase; Region: Recombinase; pfam07508
1170562000937	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
1170562000938	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
1170562000939	nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286
1170562000940	Domain of unknown function (DUF3364); Region: DUF3364; pfam11844
1170562000941	Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974
1170562000942	MoFe protein beta/alpha subunit interactions; other site
1170562000943	Beta subunit P cluster binding residues; other site
1170562000944	MoFe protein beta subunit/Fe protein contacts; other site
1170562000945	MoFe protein dimer/ dimer interactions; other site
1170562000946	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1170562000947	active site
1170562000948	catalytic residues [active]
1170562000949	DNA binding site [nucleotide binding]
1170562000950	Int/Topo IB signature motif; other site
1170562000951	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1170562000952	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1170562000953	Walker A/P-loop; other site
1170562000954	ATP binding site [chemical binding]; other site
1170562000955	Q-loop/lid; other site
1170562000956	ABC transporter signature motif; other site
1170562000957	Walker B; other site
1170562000958	D-loop; other site
1170562000959	H-loop/switch region; other site
1170562000960	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1170562000961	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1170562000962	FtsX-like permease family; Region: FtsX; pfam02687
1170562000963	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1170562000964	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1170562000965	HlyD family secretion protein; Region: HlyD_3; pfam13437
1170562000966	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1170562000967	Histidine kinase; Region: HisKA_3; pfam07730
1170562000968	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562000969	ATP binding site [chemical binding]; other site
1170562000970	Mg2+ binding site [ion binding]; other site
1170562000971	G-X-G motif; other site
1170562000972	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1170562000973	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562000974	active site
1170562000975	phosphorylation site [posttranslational modification]
1170562000976	intermolecular recognition site; other site
1170562000977	dimerization interface [polypeptide binding]; other site
1170562000978	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1170562000979	DNA binding residues [nucleotide binding]
1170562000980	dimerization interface [polypeptide binding]; other site
1170562000981	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1170562000982	Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710
1170562000983	Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976
1170562000984	MoFe protein alpha/beta subunit interactions; other site
1170562000985	Alpha subunit P cluster binding residues; other site
1170562000986	FeMoco binding residues [chemical binding]; other site
1170562000987	MoFe protein alpha subunit/Fe protein contacts; other site
1170562000988	MoFe protein dimer/ dimer interactions; other site
1170562000989	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1170562000990	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1170562000991	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1170562000992	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1170562000993	active site
1170562000994	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1170562000995	catalytic tetrad [active]
1170562000996	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
1170562000997	intracellular protease, PfpI family; Region: PfpI; TIGR01382
1170562000998	proposed catalytic triad [active]
1170562000999	conserved cys residue [active]
1170562001000	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562001001	binding surface
1170562001002	TPR motif; other site
1170562001003	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562001004	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562001005	TPR motif; other site
1170562001006	binding surface
1170562001007	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
1170562001008	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
1170562001009	cofactor binding site; other site
1170562001010	DNA binding site [nucleotide binding]
1170562001011	substrate interaction site [chemical binding]; other site
1170562001012	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1170562001013	LIM is a small protein-protein interaction domain, containing two zinc fingers; Region: LIM; cl02475
1170562001014	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1170562001015	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562001016	binding surface
1170562001017	TPR motif; other site
1170562001018	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1170562001019	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1170562001020	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
1170562001021	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1170562001022	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
1170562001023	AAA ATPase domain; Region: AAA_16; pfam13191
1170562001024	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562001025	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562001026	Uncharacterized conserved protein [Function unknown]; Region: COG4278
1170562001027	Peptidase family M48; Region: Peptidase_M48; cl12018
1170562001028	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562001029	TPR motif; other site
1170562001030	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562001031	binding surface
1170562001032	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562001033	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562001034	binding surface
1170562001035	TPR motif; other site
1170562001036	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562001037	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562001038	TPR motif; other site
1170562001039	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562001040	binding surface
1170562001041	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562001042	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562001043	binding surface
1170562001044	TPR motif; other site
1170562001045	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562001046	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562001047	binding surface
1170562001048	TPR motif; other site
1170562001049	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562001050	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562001051	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562001052	binding surface
1170562001053	TPR motif; other site
1170562001054	CHAT domain; Region: CHAT; pfam12770
1170562001055	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
1170562001056	Domain of unknown function (DUF4384); Region: DUF4384; pfam14326
1170562001057	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
1170562001058	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
1170562001059	putative active site [active]
1170562001060	putative NTP binding site [chemical binding]; other site
1170562001061	putative nucleic acid binding site [nucleotide binding]; other site
1170562001062	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
1170562001063	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
1170562001064	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
1170562001065	AAA domain; Region: AAA_33; pfam13671
1170562001066	AAA domain; Region: AAA_17; pfam13207
1170562001067	WYL domain; Region: WYL; pfam13280
1170562001068	CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577
1170562001069	CRISPR-associated protein; Region: DUF3692; pfam12469
1170562001070	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
1170562001071	CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cl17440
1170562001072	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1170562001073	LIM is a small protein-protein interaction domain, containing two zinc fingers; Region: LIM; cl02475
1170562001074	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1170562001075	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
1170562001076	AAA domain; Region: AAA_30; pfam13604
1170562001077	Family description; Region: UvrD_C_2; pfam13538
1170562001078	RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623
1170562001079	3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074
1170562001080	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1170562001081	S-adenosylmethionine binding site [chemical binding]; other site
1170562001082	Predicted kinase [General function prediction only]; Region: COG4639
1170562001083	tRNAHis guanylyltransferase; Region: Thg1; pfam04446
1170562001084	Uncharacterized conserved protein [Function unknown]; Region: COG4021
1170562001085	Thg1 C terminal domain; Region: Thg1C; pfam14413
1170562001086	polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075
1170562001087	AAA domain; Region: AAA_14; pfam13173
1170562001088	Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423
1170562001089	active site
1170562001090	metal binding site [ion binding]; metal-binding site
1170562001091	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1170562001092	putative active site [active]
1170562001093	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
1170562001094	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1170562001095	Walker A motif; other site
1170562001096	ATP binding site [chemical binding]; other site
1170562001097	Walker B motif; other site
1170562001098	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
1170562001099	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
1170562001100	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
1170562001101	haemagglutination activity domain; Region: Haemagg_act; pfam05860
1170562001102	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
1170562001103	CHASE2 domain; Region: CHASE2; pfam05226
1170562001104	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
1170562001105	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
1170562001106	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
1170562001107	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1170562001108	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1170562001109	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1170562001110	ligand binding site [chemical binding]; other site
1170562001111	flexible hinge region; other site
1170562001112	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
1170562001113	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259
1170562001114	putative active site [active]
1170562001115	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1170562001116	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1170562001117	Walker A/P-loop; other site
1170562001118	ATP binding site [chemical binding]; other site
1170562001119	Q-loop/lid; other site
1170562001120	ABC transporter signature motif; other site
1170562001121	Walker B; other site
1170562001122	D-loop; other site
1170562001123	H-loop/switch region; other site
1170562001124	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
1170562001125	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1170562001126	E3 interaction surface; other site
1170562001127	lipoyl attachment site [posttranslational modification]; other site
1170562001128	HlyD family secretion protein; Region: HlyD_3; pfam13437
1170562001129	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1170562001130	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1170562001131	Protein of unknown function (DUF1186); Region: DUF1186; pfam06685
1170562001132	Pirin-related protein [General function prediction only]; Region: COG1741
1170562001133	Pirin; Region: Pirin; pfam02678
1170562001134	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
1170562001135	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1170562001136	Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417
1170562001137	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
1170562001138	N-terminal domain interface [polypeptide binding]; other site
1170562001139	dimer interface [polypeptide binding]; other site
1170562001140	substrate binding pocket (H-site) [chemical binding]; other site
1170562001141	Chaperone of endosialidase; Region: Peptidase_S74; pfam13884
1170562001142	SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366
1170562001143	AAA ATPase domain; Region: AAA_16; pfam13191
1170562001144	FOG: WD40 repeat [General function prediction only]; Region: COG2319
1170562001145	WD40 repeats; Region: WD40; smart00320
1170562001146	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
1170562001147	structural tetrad; other site
1170562001148	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
1170562001149	structural tetrad; other site
1170562001150	FOG: WD40 repeat [General function prediction only]; Region: COG2319
1170562001151	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1170562001152	Coenzyme A binding pocket [chemical binding]; other site
1170562001153	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1170562001154	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1170562001155	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1170562001156	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1170562001157	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1170562001158	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
1170562001159	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1170562001160	hydrophobic ligand binding site; other site
1170562001161	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
1170562001162	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
1170562001163	putative active site [active]
1170562001164	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1170562001165	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1170562001166	Walker A/P-loop; other site
1170562001167	ATP binding site [chemical binding]; other site
1170562001168	Q-loop/lid; other site
1170562001169	ABC transporter signature motif; other site
1170562001170	Walker B; other site
1170562001171	D-loop; other site
1170562001172	H-loop/switch region; other site
1170562001173	AAA ATPase domain; Region: AAA_16; pfam13191
1170562001174	FOG: WD40 repeat [General function prediction only]; Region: COG2319
1170562001175	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
1170562001176	structural tetrad; other site
1170562001177	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
1170562001178	structural tetrad; other site
1170562001179	FOG: WD40 repeat [General function prediction only]; Region: COG2319
1170562001180	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
1170562001181	active site
1170562001182	metal binding site [ion binding]; metal-binding site
1170562001183	interdomain interaction site; other site
1170562001184	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
1170562001185	putative C-terminal domain interface [polypeptide binding]; other site
1170562001186	putative GSH binding site (G-site) [chemical binding]; other site
1170562001187	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1170562001188	putative dimer interface [polypeptide binding]; other site
1170562001189	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
1170562001190	dimer interface [polypeptide binding]; other site
1170562001191	N-terminal domain interface [polypeptide binding]; other site
1170562001192	putative substrate binding pocket (H-site) [chemical binding]; other site
1170562001193	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878
1170562001194	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1170562001195	non-specific DNA binding site [nucleotide binding]; other site
1170562001196	salt bridge; other site
1170562001197	sequence-specific DNA binding site [nucleotide binding]; other site
1170562001198	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
1170562001199	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1170562001200	KTSC domain; Region: KTSC; pfam13619
1170562001201	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1170562001202	Radical SAM superfamily; Region: Radical_SAM; pfam04055
1170562001203	FeS/SAM binding site; other site
1170562001204	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1170562001205	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
1170562001206	Mg binding site [ion binding]; other site
1170562001207	nucleotide binding site [chemical binding]; other site
1170562001208	putative protofilament interface [polypeptide binding]; other site
1170562001209	Plasmid recombination enzyme; Region: Mob_Pre; pfam01076
1170562001210	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
1170562001211	Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942
1170562001212	active site 1 [active]
1170562001213	dimer interface [polypeptide binding]; other site
1170562001214	hexamer interface [polypeptide binding]; other site
1170562001215	active site 2 [active]
1170562001216	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1170562001217	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1170562001218	Walker A motif; other site
1170562001219	ATP binding site [chemical binding]; other site
1170562001220	Walker B motif; other site
1170562001221	arginine finger; other site
1170562001222	AAA-like domain; Region: AAA_10; pfam12846
1170562001223	replicative DNA helicase; Region: DnaB; TIGR00665
1170562001224	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1170562001225	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1170562001226	Walker A motif; other site
1170562001227	ATP binding site [chemical binding]; other site
1170562001228	Walker B motif; other site
1170562001229	DNA binding loops [nucleotide binding]
1170562001230	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1170562001231	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
1170562001232	catalytic residues [active]
1170562001233	catalytic nucleophile [active]
1170562001234	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
1170562001235	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1170562001236	Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000
1170562001237	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
1170562001238	trimerization site [polypeptide binding]; other site
1170562001239	active site
1170562001240	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1170562001241	NifU-like domain; Region: NifU; pfam01106
1170562001242	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1170562001243	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
1170562001244	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1170562001245	catalytic residue [active]
1170562001246	4Fe-4S binding domain; Region: Fer4; cl02805
1170562001247	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
1170562001248	nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290
1170562001249	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1170562001250	FeS/SAM binding site; other site
1170562001251	NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852
1170562001252	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
1170562001253	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1170562001254	active site
1170562001255	catalytic residues [active]
1170562001256	DNA binding site [nucleotide binding]
1170562001257	Int/Topo IB signature motif; other site
1170562001258	Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150
1170562001259	Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136
1170562001260	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1170562001261	Probable transposase; Region: OrfB_IS605; pfam01385
1170562001262	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
1170562001263	Domain of unknown function (DUF4404); Region: DUF4404; pfam14357
1170562001264	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
1170562001265	hydrogenase 2 large subunit; Provisional; Region: PRK10467
1170562001266	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
1170562001267	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
1170562001268	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1170562001269	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1170562001270	Walker A motif; other site
1170562001271	ATP binding site [chemical binding]; other site
1170562001272	Walker B motif; other site
1170562001273	arginine finger; other site
1170562001274	Protein of unknown function (DUF4255); Region: DUF4255; pfam14065
1170562001275	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
1170562001276	Phage tail sheath protein FI [General function prediction only]; Region: COG3497
1170562001277	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841
1170562001278	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl17313
1170562001279	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
1170562001280	Phage protein D [General function prediction only]; Region: COG3500
1170562001281	Rhs element Vgr protein; Region: vgr_GE; TIGR01646
1170562001282	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
1170562001283	Uncharacterized conserved protein [Function unknown]; Region: COG4104
1170562001284	Gene 25-like lysozyme; Region: GPW_gp25; cl01403
1170562001285	Carbohydrate binding domain; Region: CBM_5_12; pfam02839
1170562001286	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
1170562001287	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
1170562001288	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
1170562001289	Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910
1170562001290	PIN domain; Region: PIN_3; cl17397
1170562001291	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1170562001292	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1170562001293	catalytic residues [active]
1170562001294	catalytic nucleophile [active]
1170562001295	Presynaptic Site I dimer interface [polypeptide binding]; other site
1170562001296	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1170562001297	Synaptic Flat tetramer interface [polypeptide binding]; other site
1170562001298	Synaptic Site I dimer interface [polypeptide binding]; other site
1170562001299	DNA binding site [nucleotide binding]
1170562001300	Recombinase; Region: Recombinase; pfam07508
1170562001301	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
1170562001302	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
1170562001303	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1170562001304	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1170562001305	Sm and related proteins; Region: Sm_like; cl00259
1170562001306	heptamer interface [polypeptide binding]; other site
1170562001307	Sm1 motif; other site
1170562001308	hexamer interface [polypeptide binding]; other site
1170562001309	RNA binding site [nucleotide binding]; other site
1170562001310	Sm2 motif; other site
1170562001311	GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914
1170562001312	GDP-Fucose binding site [chemical binding]; other site
1170562001313	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1170562001314	active site
1170562001315	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1170562001316	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1170562001317	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
1170562001318	TrkA-N domain; Region: TrkA_N; pfam02254
1170562001319	TrkA-C domain; Region: TrkA_C; pfam02080
1170562001320	TrkA-C domain; Region: TrkA_C; pfam02080
1170562001321	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1170562001322	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1170562001323	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
1170562001324	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1170562001325	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
1170562001326	C-terminal domain interface [polypeptide binding]; other site
1170562001327	GSH binding site (G-site) [chemical binding]; other site
1170562001328	dimer interface [polypeptide binding]; other site
1170562001329	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
1170562001330	N-terminal domain interface [polypeptide binding]; other site
1170562001331	dimer interface [polypeptide binding]; other site
1170562001332	substrate binding pocket (H-site) [chemical binding]; other site
1170562001333	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1170562001334	Peptidase family M23; Region: Peptidase_M23; pfam01551
1170562001335	Late competence development protein ComFB; Region: ComFB; pfam10719
1170562001336	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1170562001337	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1170562001338	excinuclease ABC subunit B; Provisional; Region: PRK05298
1170562001339	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1170562001340	ATP binding site [chemical binding]; other site
1170562001341	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1170562001342	putative Mg++ binding site [ion binding]; other site
1170562001343	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1170562001344	nucleotide binding region [chemical binding]; other site
1170562001345	ATP-binding site [chemical binding]; other site
1170562001346	Ultra-violet resistance protein B; Region: UvrB; pfam12344
1170562001347	Protein of unknown function (DUF497); Region: DUF497; pfam04365
1170562001348	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
1170562001349	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
1170562001350	Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580
1170562001351	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1170562001352	S-adenosylmethionine binding site [chemical binding]; other site
1170562001353	Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109
1170562001354	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
1170562001355	active site
1170562001356	putative homodimer interface [polypeptide binding]; other site
1170562001357	SAM binding site [chemical binding]; other site
1170562001358	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
1170562001359	precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469
1170562001360	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
1170562001361	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1170562001362	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1170562001363	The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988
1170562001364	Ligand Binding Site [chemical binding]; other site
1170562001365	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1170562001366	Ligand Binding Site [chemical binding]; other site
1170562001367	PAS fold; Region: PAS_4; pfam08448
1170562001368	PAS domain S-box; Region: sensory_box; TIGR00229
1170562001369	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562001370	putative active site [active]
1170562001371	heme pocket [chemical binding]; other site
1170562001372	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1170562001373	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1170562001374	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1170562001375	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562001376	dimer interface [polypeptide binding]; other site
1170562001377	phosphorylation site [posttranslational modification]
1170562001378	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562001379	ATP binding site [chemical binding]; other site
1170562001380	Mg2+ binding site [ion binding]; other site
1170562001381	G-X-G motif; other site
1170562001382	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1170562001383	exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005
1170562001384	Merozoite surface protein 1 (MSP1) C-terminus; Region: MSP1_C; pfam07462
1170562001385	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
1170562001386	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
1170562001387	active site
1170562001388	dimer interface [polypeptide binding]; other site
1170562001389	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1170562001390	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
1170562001391	putative NAD(P) binding site [chemical binding]; other site
1170562001392	homodimer interface [polypeptide binding]; other site
1170562001393	homotetramer interface [polypeptide binding]; other site
1170562001394	active site
1170562001395	tellurite resistance protein terB; Region: terB; cd07176
1170562001396	putative metal binding site [ion binding]; other site
1170562001397	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1170562001398	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
1170562001399	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1170562001400	active site
1170562001401	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
1170562001402	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
1170562001403	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
1170562001404	G1 box; other site
1170562001405	putative GEF interaction site [polypeptide binding]; other site
1170562001406	GTP/Mg2+ binding site [chemical binding]; other site
1170562001407	Switch I region; other site
1170562001408	G2 box; other site
1170562001409	G3 box; other site
1170562001410	Switch II region; other site
1170562001411	G4 box; other site
1170562001412	G5 box; other site
1170562001413	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
1170562001414	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
1170562001415	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1170562001416	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
1170562001417	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
1170562001418	putative active site pocket [active]
1170562001419	dimerization interface [polypeptide binding]; other site
1170562001420	putative catalytic residue [active]
1170562001421	Putative zinc-finger; Region: zf-HC2; pfam13490
1170562001422	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
1170562001423	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1170562001424	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1170562001425	DNA binding residues [nucleotide binding]
1170562001426	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
1170562001427	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
1170562001428	trimer interface [polypeptide binding]; other site
1170562001429	active site
1170562001430	substrate binding site [chemical binding]; other site
1170562001431	CoA binding site [chemical binding]; other site
1170562001432	Uncharacterized conserved protein [Function unknown]; Region: COG1479
1170562001433	Protein of unknown function DUF262; Region: DUF262; pfam03235
1170562001434	Uncharacterized conserved protein [Function unknown]; Region: COG3472
1170562001435	threonine dehydratase; Reviewed; Region: PRK09224
1170562001436	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1170562001437	tetramer interface [polypeptide binding]; other site
1170562001438	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1170562001439	catalytic residue [active]
1170562001440	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
1170562001441	putative Ile/Val binding site [chemical binding]; other site
1170562001442	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
1170562001443	putative Ile/Val binding site [chemical binding]; other site
1170562001444	FOG: WD40 repeat [General function prediction only]; Region: COG2319
1170562001445	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
1170562001446	structural tetrad; other site
1170562001447	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1170562001448	HSP70 interaction site [polypeptide binding]; other site
1170562001449	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
1170562001450	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
1170562001451	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
1170562001452	dimerization interface [polypeptide binding]; other site
1170562001453	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
1170562001454	ATP binding site [chemical binding]; other site
1170562001455	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
1170562001456	active site 1 [active]
1170562001457	dimer interface [polypeptide binding]; other site
1170562001458	hexamer interface [polypeptide binding]; other site
1170562001459	active site 2 [active]
1170562001460	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
1170562001461	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
1170562001462	HupF/HypC family; Region: HupF_HypC; pfam01455
1170562001463	Acylphosphatase; Region: Acylphosphatase; pfam00708
1170562001464	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
1170562001465	HypF finger; Region: zf-HYPF; pfam07503
1170562001466	HypF finger; Region: zf-HYPF; pfam07503
1170562001467	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
1170562001468	Cu2+-containing amine oxidase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TynA; COG3733
1170562001469	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
1170562001470	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1170562001471	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1170562001472	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
1170562001473	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1170562001474	FeS/SAM binding site; other site
1170562001475	HemN C-terminal domain; Region: HemN_C; pfam06969
1170562001476	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
1170562001477	heme binding pocket [chemical binding]; other site
1170562001478	heme ligand [chemical binding]; other site
1170562001479	Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047
1170562001480	diiron binding motif [ion binding]; other site
1170562001481	AMIN domain; Region: AMIN; pfam11741
1170562001482	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
1170562001483	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1170562001484	N-terminal plug; other site
1170562001485	ligand-binding site [chemical binding]; other site
1170562001486	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
1170562001487	iron-sulfur cluster [ion binding]; other site
1170562001488	[2Fe-2S] cluster binding site [ion binding]; other site
1170562001489	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
1170562001490	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
1170562001491	tetramer interface [polypeptide binding]; other site
1170562001492	heme binding pocket [chemical binding]; other site
1170562001493	NADPH binding site [chemical binding]; other site
1170562001494	PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595
1170562001495	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
1170562001496	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
1170562001497	putative dimer interface [polypeptide binding]; other site
1170562001498	putative anticodon binding site; other site
1170562001499	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
1170562001500	homodimer interface [polypeptide binding]; other site
1170562001501	motif 1; other site
1170562001502	motif 2; other site
1170562001503	active site
1170562001504	motif 3; other site
1170562001505	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1170562001506	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1170562001507	Walker A motif; other site
1170562001508	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
1170562001509	protein-splicing catalytic site; other site
1170562001510	thioester formation/cholesterol transfer; other site
1170562001511	Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372
1170562001512	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1170562001513	non-specific DNA binding site [nucleotide binding]; other site
1170562001514	salt bridge; other site
1170562001515	sequence-specific DNA binding site [nucleotide binding]; other site
1170562001516	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
1170562001517	protein-splicing catalytic site; other site
1170562001518	replicative DNA helicase; Region: DnaB; TIGR00665
1170562001519	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1170562001520	ATP binding site [chemical binding]; other site
1170562001521	Walker B motif; other site
1170562001522	DNA binding loops [nucleotide binding]
1170562001523	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
1170562001524	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1170562001525	Uncharacterized conserved protein [Function unknown]; Region: COG3937
1170562001526	Protein of unknown function (DUF2656); Region: DUF2656; pfam10847
1170562001527	phosphoribulokinase; Provisional; Region: PRK07429
1170562001528	Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026
1170562001529	active site
1170562001530	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
1170562001531	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1170562001532	S-adenosylmethionine binding site [chemical binding]; other site
1170562001533	Putative serine esterase (DUF676); Region: DUF676; pfam05057
1170562001534	Predicted sulfurtransferase [General function prediction only]; Region: COG1054
1170562001535	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
1170562001536	active site residue [active]
1170562001537	BNR repeat-like domain; Region: BNR_2; pfam13088
1170562001538	VPS10 domain; Region: VPS10; smart00602
1170562001539	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1170562001540	G1 box; other site
1170562001541	GTP/Mg2+ binding site [chemical binding]; other site
1170562001542	G2 box; other site
1170562001543	Switch I region; other site
1170562001544	G3 box; other site
1170562001545	Switch II region; other site
1170562001546	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1170562001547	G1 box; other site
1170562001548	GTP/Mg2+ binding site [chemical binding]; other site
1170562001549	G2 box; other site
1170562001550	Switch I region; other site
1170562001551	G3 box; other site
1170562001552	Switch II region; other site
1170562001553	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
1170562001554	Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318
1170562001555	active site
1170562001556	Na/Ca binding site [ion binding]; other site
1170562001557	catalytic site [active]
1170562001558	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1170562001559	dimerization interface [polypeptide binding]; other site
1170562001560	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1170562001561	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1170562001562	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1170562001563	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1170562001564	dimer interface [polypeptide binding]; other site
1170562001565	putative CheW interface [polypeptide binding]; other site
1170562001566	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
1170562001567	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
1170562001568	Domain of unknown function (DUF814); Region: DUF814; pfam05670
1170562001569	Curli production assembly/transport component CsgG; Region: CsgG; pfam03783
1170562001570	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1170562001571	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1170562001572	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1170562001573	Coenzyme A binding pocket [chemical binding]; other site
1170562001574	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
1170562001575	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1170562001576	Coenzyme A binding pocket [chemical binding]; other site
1170562001577	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1170562001578	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1170562001579	Coenzyme A binding pocket [chemical binding]; other site
1170562001580	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
1170562001581	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
1170562001582	dinuclear metal binding motif [ion binding]; other site
1170562001583	enolase; Provisional; Region: eno; PRK00077
1170562001584	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
1170562001585	dimer interface [polypeptide binding]; other site
1170562001586	metal binding site [ion binding]; metal-binding site
1170562001587	substrate binding pocket [chemical binding]; other site
1170562001588	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
1170562001589	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
1170562001590	Protein of unknown function, DUF399; Region: DUF399; pfam04187
1170562001591	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1170562001592	putative active site [active]
1170562001593	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562001594	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562001595	active site
1170562001596	phosphorylation site [posttranslational modification]
1170562001597	intermolecular recognition site; other site
1170562001598	dimerization interface [polypeptide binding]; other site
1170562001599	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562001600	dimer interface [polypeptide binding]; other site
1170562001601	phosphorylation site [posttranslational modification]
1170562001602	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562001603	ATP binding site [chemical binding]; other site
1170562001604	Mg2+ binding site [ion binding]; other site
1170562001605	G-X-G motif; other site
1170562001606	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1170562001607	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1170562001608	dimerization interface [polypeptide binding]; other site
1170562001609	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562001610	dimer interface [polypeptide binding]; other site
1170562001611	phosphorylation site [posttranslational modification]
1170562001612	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562001613	ATP binding site [chemical binding]; other site
1170562001614	Mg2+ binding site [ion binding]; other site
1170562001615	G-X-G motif; other site
1170562001616	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1170562001617	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562001618	active site
1170562001619	phosphorylation site [posttranslational modification]
1170562001620	intermolecular recognition site; other site
1170562001621	dimerization interface [polypeptide binding]; other site
1170562001622	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1170562001623	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1170562001624	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1170562001625	Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643
1170562001626	active site
1170562001627	PUCC protein; Region: PUCC; pfam03209
1170562001628	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1170562001629	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1170562001630	active site
1170562001631	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1170562001632	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
1170562001633	pyruvate kinase; Provisional; Region: PRK06354
1170562001634	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
1170562001635	domain interfaces; other site
1170562001636	active site
1170562001637	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
1170562001638	Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514
1170562001639	Fatty acid desaturase; Region: FA_desaturase; pfam00487
1170562001640	putative di-iron ligands [ion binding]; other site
1170562001641	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185
1170562001642	homotrimer interaction site [polypeptide binding]; other site
1170562001643	active site
1170562001644	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
1170562001645	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
1170562001646	tandem repeat interface [polypeptide binding]; other site
1170562001647	oligomer interface [polypeptide binding]; other site
1170562001648	active site residues [active]
1170562001649	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
1170562001650	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1170562001651	Permease; Region: Permease; cl00510
1170562001652	Protein of unknown function (DUF3119); Region: DUF3119; pfam11317
1170562001653	Protein of unknown function (DUF3086); Region: DUF3086; pfam11285
1170562001654	membrane protein; Provisional; Region: PRK14419
1170562001655	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1170562001656	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562001657	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562001658	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1170562001659	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562001660	PAP_fibrillin; Region: PAP_fibrillin; pfam04755
1170562001661	short chain dehydrogenase; Provisional; Region: PRK08303
1170562001662	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1170562001663	NAD(P) binding site [chemical binding]; other site
1170562001664	active site
1170562001665	ketol-acid reductoisomerase; Provisional; Region: PRK05479
1170562001666	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
1170562001667	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
1170562001668	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
1170562001669	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1170562001670	C factor cell-cell signaling protein; Provisional; Region: PRK09009
1170562001671	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
1170562001672	NADP binding site [chemical binding]; other site
1170562001673	homodimer interface [polypeptide binding]; other site
1170562001674	active site
1170562001675	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4402
1170562001676	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779
1170562001677	Uncharacterized conserved protein [Function unknown]; Region: COG3791
1170562001678	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
1170562001679	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1170562001680	Family description; Region: UvrD_C_2; pfam13538
1170562001681	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
1170562001682	uncharacterized cyanobacterial protein, TIGR03792 family; Region: TIGR03792
1170562001683	Uncharacterized conserved protein [Function unknown]; Region: COG1434
1170562001684	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1170562001685	putative active site [active]
1170562001686	Ferredoxin thioredoxin reductase variable alpha chain; Region: FeThRed_A; pfam02941
1170562001687	putative protein serine/threonine phosphatase; Provisional; Region: PRK14559
1170562001688	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
1170562001689	active site
1170562001690	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
1170562001691	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
1170562001692	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
1170562001693	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
1170562001694	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
1170562001695	heme bL binding site [chemical binding]; other site
1170562001696	interchain domain interface [polypeptide binding]; other site
1170562001697	intrachain domain interface; other site
1170562001698	heme bH binding site [chemical binding]; other site
1170562001699	Qo binding site; other site
1170562001700	Caspase domain; Region: Peptidase_C14; pfam00656
1170562001701	DNA-directed RNA polymerase specialized sigma subunit [Transcription]; Region: FliA; COG1191
1170562001702	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
1170562001703	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1170562001704	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1170562001705	active site
1170562001706	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
1170562001707	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1170562001708	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1170562001709	active site
1170562001710	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
1170562001711	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1170562001712	trimer interface [polypeptide binding]; other site
1170562001713	active site
1170562001714	substrate binding site [chemical binding]; other site
1170562001715	CoA binding site [chemical binding]; other site
1170562001716	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
1170562001717	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
1170562001718	Chain length determinant protein; Region: Wzz; pfam02706
1170562001719	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1170562001720	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1170562001721	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1170562001722	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1170562001723	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1170562001724	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562001725	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562001726	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1170562001727	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562001728	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1170562001729	putative trimer interface [polypeptide binding]; other site
1170562001730	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
1170562001731	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
1170562001732	trimer interface [polypeptide binding]; other site
1170562001733	active site
1170562001734	substrate binding site [chemical binding]; other site
1170562001735	putative CoA binding site [chemical binding]; other site
1170562001736	CoA binding site [chemical binding]; other site
1170562001737	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
1170562001738	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
1170562001739	trimer interface [polypeptide binding]; other site
1170562001740	active site
1170562001741	substrate binding site [chemical binding]; other site
1170562001742	CoA binding site [chemical binding]; other site
1170562001743	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1170562001744	Inward rectifier potassium channel; Region: IRK; pfam01007
1170562001745	sucrose-6F-phosphate phosphohydrolase; Region: SPP_plant-cyano; TIGR01485
1170562001746	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
1170562001747	RuvA N terminal domain; Region: RuvA_N; pfam01330
1170562001748	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
1170562001749	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
1170562001750	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
1170562001751	substrate-cofactor binding pocket; other site
1170562001752	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1170562001753	catalytic residue [active]
1170562001754	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1170562001755	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1170562001756	dimerization interface [polypeptide binding]; other site
1170562001757	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562001758	dimer interface [polypeptide binding]; other site
1170562001759	phosphorylation site [posttranslational modification]
1170562001760	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562001761	ATP binding site [chemical binding]; other site
1170562001762	Mg2+ binding site [ion binding]; other site
1170562001763	G-X-G motif; other site
1170562001764	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1170562001765	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562001766	active site
1170562001767	phosphorylation site [posttranslational modification]
1170562001768	intermolecular recognition site; other site
1170562001769	dimerization interface [polypeptide binding]; other site
1170562001770	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1170562001771	DNA binding site [nucleotide binding]
1170562001772	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
1170562001773	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
1170562001774	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1170562001775	active site
1170562001776	ATP binding site [chemical binding]; other site
1170562001777	substrate binding site [chemical binding]; other site
1170562001778	activation loop (A-loop); other site
1170562001779	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1170562001780	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1170562001781	active site
1170562001782	ATP binding site [chemical binding]; other site
1170562001783	substrate binding site [chemical binding]; other site
1170562001784	activation loop (A-loop); other site
1170562001785	YARHG domain; Region: YARHG; pfam13308
1170562001786	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1170562001787	catalytic core [active]
1170562001788	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1170562001789	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1170562001790	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1170562001791	catalytic residue [active]
1170562001792	RecB family nuclease, putative, TM0106 family; Region: TIGR03491
1170562001793	RNase_H superfamily; Region: RNase_H_2; pfam13482
1170562001794	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
1170562001795	nucleotide binding site/active site [active]
1170562001796	HIT family signature motif; other site
1170562001797	catalytic residue [active]
1170562001798	D1 subunit  of photosystem II (PS II); Region: Photosystem-II_D1; cd09289
1170562001799	protein I interface; other site
1170562001800	D2 interface; other site
1170562001801	protein T interface; other site
1170562001802	chlorophyll binding site; other site
1170562001803	beta carotene binding site; other site
1170562001804	pheophytin binding site; other site
1170562001805	manganese-stabilizing polypeptide interface; other site
1170562001806	CP43 interface; other site
1170562001807	protein L interface; other site
1170562001808	oxygen evolving complex binding site; other site
1170562001809	bromide binding site; other site
1170562001810	quinone binding site; other site
1170562001811	Fe binding site [ion binding]; other site
1170562001812	core light harvesting interface; other site
1170562001813	cytochrome b559 alpha subunit interface; other site
1170562001814	cytochrome c-550 interface; other site
1170562001815	protein J interface; other site
1170562001816	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
1170562001817	serine O-acetyltransferase; Region: cysE; TIGR01172
1170562001818	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1170562001819	trimer interface [polypeptide binding]; other site
1170562001820	active site
1170562001821	substrate binding site [chemical binding]; other site
1170562001822	CoA binding site [chemical binding]; other site
1170562001823	thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352
1170562001824	thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190
1170562001825	Dicarboxylate transport; Region: DctA-YdbH; cl14674
1170562001826	Family of unknown function (DUF490); Region: DUF490; pfam04357
1170562001827	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1170562001828	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1170562001829	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1170562001830	catalytic residue [active]
1170562001831	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1170562001832	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1170562001833	active site
1170562001834	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562001835	PAS domain; Region: PAS_9; pfam13426
1170562001836	putative active site [active]
1170562001837	heme pocket [chemical binding]; other site
1170562001838	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1170562001839	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1170562001840	PAS domain S-box; Region: sensory_box; TIGR00229
1170562001841	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562001842	putative active site [active]
1170562001843	heme pocket [chemical binding]; other site
1170562001844	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
1170562001845	cyclase homology domain; Region: CHD; cd07302
1170562001846	nucleotidyl binding site; other site
1170562001847	metal binding site [ion binding]; metal-binding site
1170562001848	dimer interface [polypeptide binding]; other site
1170562001849	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1170562001850	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562001851	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562001852	TPR repeat; Region: TPR_11; pfam13414
1170562001853	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562001854	binding surface
1170562001855	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
1170562001856	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
1170562001857	active site
1170562001858	TDP-binding site; other site
1170562001859	acceptor substrate-binding pocket; other site
1170562001860	homodimer interface [polypeptide binding]; other site
1170562001861	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
1170562001862	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562001863	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
1170562001864	Family description; Region: UvrD_C_2; pfam13538
1170562001865	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1170562001866	putative active site [active]
1170562001867	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
1170562001868	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07428
1170562001869	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
1170562001870	dimerization interface [polypeptide binding]; other site
1170562001871	active site
1170562001872	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1170562001873	putative active site [active]
1170562001874	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
1170562001875	MreB/Mbl protein; Region: MreB_Mbl; pfam06723
1170562001876	nucleotide binding site [chemical binding]; other site
1170562001877	putative NEF/HSP70 interaction site [polypeptide binding]; other site
1170562001878	SBD interface [polypeptide binding]; other site
1170562001879	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1170562001880	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1170562001881	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
1170562001882	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
1170562001883	NADP binding site [chemical binding]; other site
1170562001884	active site
1170562001885	putative substrate binding site [chemical binding]; other site
1170562001886	nuc_hydro_ TvIAG:  Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax.   Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647
1170562001887	active site
1170562001888	dimerization interface [polypeptide binding]; other site
1170562001889	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
1170562001890	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1170562001891	substrate binding site [chemical binding]; other site
1170562001892	dimer interface [polypeptide binding]; other site
1170562001893	ATP binding site [chemical binding]; other site
1170562001894	Calcium binding; Region: Calci_bind_CcbP; pfam11535
1170562001895	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1170562001896	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1170562001897	P-loop; other site
1170562001898	Magnesium ion binding site [ion binding]; other site
1170562001899	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1170562001900	Magnesium ion binding site [ion binding]; other site
1170562001901	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1170562001902	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1170562001903	P-loop; other site
1170562001904	Magnesium ion binding site [ion binding]; other site
1170562001905	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1170562001906	Magnesium ion binding site [ion binding]; other site
1170562001907	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
1170562001908	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12567
1170562001909	hypothetical protein; Provisional; Region: PRK07377
1170562001910	Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; pfam03334
1170562001911	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07234
1170562001912	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1170562001913	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08389
1170562001914	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
1170562001915	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1170562001916	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
1170562001917	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1170562001918	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
1170562001919	active site
1170562001920	phosphorylation site [posttranslational modification]
1170562001921	intermolecular recognition site; other site
1170562001922	PAS domain; Region: PAS_9; pfam13426
1170562001923	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1170562001924	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562001925	putative active site [active]
1170562001926	heme pocket [chemical binding]; other site
1170562001927	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562001928	dimer interface [polypeptide binding]; other site
1170562001929	phosphorylation site [posttranslational modification]
1170562001930	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562001931	ATP binding site [chemical binding]; other site
1170562001932	Mg2+ binding site [ion binding]; other site
1170562001933	G-X-G motif; other site
1170562001934	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562001935	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562001936	active site
1170562001937	phosphorylation site [posttranslational modification]
1170562001938	intermolecular recognition site; other site
1170562001939	dimerization interface [polypeptide binding]; other site
1170562001940	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1170562001941	active site
1170562001942	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1170562001943	Domain of unknown function DUF21; Region: DUF21; pfam01595
1170562001944	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1170562001945	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
1170562001946	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
1170562001947	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1170562001948	Probable transposase; Region: OrfB_IS605; pfam01385
1170562001949	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
1170562001950	Uncharacterized conserved protein (DUF2349); Region: DUF2349; pfam09779
1170562001951	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
1170562001952	Ferritin-like domain; Region: Ferritin; pfam00210
1170562001953	dimanganese center [ion binding]; other site
1170562001954	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
1170562001955	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
1170562001956	Protein of unknown function (DUF1624); Region: DUF1624; cl01394
1170562001957	Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249
1170562001958	Caspase domain; Region: Peptidase_C14; pfam00656
1170562001959	FOG: WD40 repeat [General function prediction only]; Region: COG2319
1170562001960	WD domain, G-beta repeat; Region: WD40; pfam00400
1170562001961	WD40 repeats; Region: WD40; smart00320
1170562001962	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
1170562001963	structural tetrad; other site
1170562001964	FOG: WD40 repeat [General function prediction only]; Region: COG2319
1170562001965	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
1170562001966	structural tetrad; other site
1170562001967	Leucine rich repeat; Region: LRR_8; pfam13855
1170562001968	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
1170562001969	Leucine-rich repeats; other site
1170562001970	Substrate binding site [chemical binding]; other site
1170562001971	Leucine rich repeat; Region: LRR_8; pfam13855
1170562001972	Leucine rich repeat; Region: LRR_8; pfam13855
1170562001973	Leucine rich repeat; Region: LRR_8; pfam13855
1170562001974	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
1170562001975	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1170562001976	G1 box; other site
1170562001977	GTP/Mg2+ binding site [chemical binding]; other site
1170562001978	G2 box; other site
1170562001979	Switch I region; other site
1170562001980	G3 box; other site
1170562001981	Switch II region; other site
1170562001982	G4 box; other site
1170562001983	G5 box; other site
1170562001984	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1170562001985	salt bridge; other site
1170562001986	non-specific DNA binding site [nucleotide binding]; other site
1170562001987	sequence-specific DNA binding site [nucleotide binding]; other site
1170562001988	Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907
1170562001989	S-layer homology domain; Region: SLH; pfam00395
1170562001990	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
1170562001991	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1170562001992	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
1170562001993	dimer interface [polypeptide binding]; other site
1170562001994	active site
1170562001995	metal binding site [ion binding]; metal-binding site
1170562001996	glutathione binding site [chemical binding]; other site
1170562001997	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544
1170562001998	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1170562001999	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1170562002000	Walker A/P-loop; other site
1170562002001	ATP binding site [chemical binding]; other site
1170562002002	Q-loop/lid; other site
1170562002003	ABC transporter signature motif; other site
1170562002004	Walker B; other site
1170562002005	D-loop; other site
1170562002006	H-loop/switch region; other site
1170562002007	NMT1/THI5 like; Region: NMT1; pfam09084
1170562002008	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1170562002009	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1170562002010	active site
1170562002011	ATP binding site [chemical binding]; other site
1170562002012	substrate binding site [chemical binding]; other site
1170562002013	activation loop (A-loop); other site
1170562002014	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
1170562002015	structural tetrad; other site
1170562002016	PQQ-like domain; Region: PQQ_2; pfam13360
1170562002017	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1170562002018	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1170562002019	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
1170562002020	putative dimerization interface [polypeptide binding]; other site
1170562002021	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
1170562002022	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
1170562002023	Hexamer interface [polypeptide binding]; other site
1170562002024	Hexagonal pore residue; other site
1170562002025	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
1170562002026	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
1170562002027	Hexamer interface [polypeptide binding]; other site
1170562002028	Hexagonal pore residue; other site
1170562002029	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1170562002030	putative trimer interface [polypeptide binding]; other site
1170562002031	putative CoA binding site [chemical binding]; other site
1170562002032	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
1170562002033	Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710
1170562002034	trimer interface [polypeptide binding]; other site
1170562002035	active site
1170562002036	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
1170562002037	putative multimerization interface [polypeptide binding]; other site
1170562002038	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
1170562002039	putative multimerization interface [polypeptide binding]; other site
1170562002040	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
1170562002041	putative multimerization interface [polypeptide binding]; other site
1170562002042	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
1170562002043	Hexamer/Pentamer interface [polypeptide binding]; other site
1170562002044	central pore; other site
1170562002045	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
1170562002046	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
1170562002047	Hexamer interface [polypeptide binding]; other site
1170562002048	Hexagonal pore residue; other site
1170562002049	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
1170562002050	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
1170562002051	Hexamer interface [polypeptide binding]; other site
1170562002052	Hexagonal pore residue; other site
1170562002053	NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390
1170562002054	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
1170562002055	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1170562002056	NAD(P)H-quinone oxidoreductase subunit D4; Validated; Region: PRK06473
1170562002057	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1170562002058	CO2 hydration protein (ChpXY); Region: ChpXY; pfam10216
1170562002059	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1170562002060	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562002061	active site
1170562002062	phosphorylation site [posttranslational modification]
1170562002063	intermolecular recognition site; other site
1170562002064	dimerization interface [polypeptide binding]; other site
1170562002065	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1170562002066	DNA binding residues [nucleotide binding]
1170562002067	dimerization interface [polypeptide binding]; other site
1170562002068	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1170562002069	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562002070	dimer interface [polypeptide binding]; other site
1170562002071	phosphorylation site [posttranslational modification]
1170562002072	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562002073	ATP binding site [chemical binding]; other site
1170562002074	Mg2+ binding site [ion binding]; other site
1170562002075	G-X-G motif; other site
1170562002076	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
1170562002077	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
1170562002078	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1170562002079	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1170562002080	potassium-transporting ATPase subunit C; Provisional; Region: PRK14003
1170562002081	glycogen synthase; Provisional; Region: glgA; PRK00654
1170562002082	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
1170562002083	ADP-binding pocket [chemical binding]; other site
1170562002084	homodimer interface [polypeptide binding]; other site
1170562002085	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
1170562002086	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
1170562002087	domain interfaces; other site
1170562002088	active site
1170562002089	putative lipid kinase; Reviewed; Region: PRK00861
1170562002090	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1170562002091	DNA polymerase III subunit alpha; Reviewed; Region: PRK09532
1170562002092	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
1170562002093	active site
1170562002094	PHP Thumb interface [polypeptide binding]; other site
1170562002095	metal binding site [ion binding]; metal-binding site
1170562002096	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
1170562002097	protein-splicing catalytic site; other site
1170562002098	thioester formation/cholesterol transfer; other site
1170562002099	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
1170562002100	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
1170562002101	D1 subunit  of photosystem II (PS II); Region: Photosystem-II_D1; cd09289
1170562002102	protein I interface; other site
1170562002103	D2 interface; other site
1170562002104	protein T interface; other site
1170562002105	chlorophyll binding site; other site
1170562002106	beta carotene binding site; other site
1170562002107	pheophytin binding site; other site
1170562002108	manganese-stabilizing polypeptide interface; other site
1170562002109	CP43 interface; other site
1170562002110	protein L interface; other site
1170562002111	oxygen evolving complex binding site; other site
1170562002112	bromide binding site; other site
1170562002113	quinone binding site; other site
1170562002114	Fe binding site [ion binding]; other site
1170562002115	core light harvesting interface; other site
1170562002116	cytochrome b559 alpha subunit interface; other site
1170562002117	cytochrome c-550 interface; other site
1170562002118	protein J interface; other site
1170562002119	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1170562002120	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1170562002121	DNA binding residues [nucleotide binding]
1170562002122	FO synthase subunit 1; Reviewed; Region: cofG; PRK06245
1170562002123	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1170562002124	FeS/SAM binding site; other site
1170562002125	TPR repeat; Region: TPR_11; pfam13414
1170562002126	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562002127	binding surface
1170562002128	TPR motif; other site
1170562002129	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562002130	binding surface
1170562002131	TPR repeat; Region: TPR_11; pfam13414
1170562002132	TPR motif; other site
1170562002133	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1170562002134	S-layer homology domain; Region: SLH; pfam00395
1170562002135	S-layer homology domain; Region: SLH; pfam00395
1170562002136	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
1170562002137	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
1170562002138	lipoyl synthase; Provisional; Region: PRK05481
1170562002139	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1170562002140	FeS/SAM binding site; other site
1170562002141	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
1170562002142	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1170562002143	Uncharacterized conserved protein [Function unknown]; Region: COG5464
1170562002144	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
1170562002145	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755
1170562002146	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
1170562002147	RNA binding site [nucleotide binding]; other site
1170562002148	active site
1170562002149	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
1170562002150	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1170562002151	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1170562002152	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1170562002153	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1170562002154	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562002155	PAS domain; Region: PAS_9; pfam13426
1170562002156	putative active site [active]
1170562002157	heme pocket [chemical binding]; other site
1170562002158	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1170562002159	cyclase homology domain; Region: CHD; cd07302
1170562002160	nucleotidyl binding site; other site
1170562002161	metal binding site [ion binding]; metal-binding site
1170562002162	dimer interface [polypeptide binding]; other site
1170562002163	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
1170562002164	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
1170562002165	Surface antigen; Region: Bac_surface_Ag; pfam01103
1170562002166	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1170562002167	Probable transposase; Region: OrfB_IS605; pfam01385
1170562002168	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
1170562002169	Uncharacterized conserved protein (DUF2349); Region: DUF2349; pfam09779
1170562002170	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
1170562002171	HlyD family secretion protein; Region: HlyD_3; pfam13437
1170562002172	RDD family; Region: RDD; pfam06271
1170562002173	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1170562002174	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1170562002175	active site
1170562002176	ATP binding site [chemical binding]; other site
1170562002177	substrate binding site [chemical binding]; other site
1170562002178	activation loop (A-loop); other site
1170562002179	RDD family; Region: RDD; pfam06271
1170562002180	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
1170562002181	catalytic residues [active]
1170562002182	dimer interface [polypeptide binding]; other site
1170562002183	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1170562002184	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
1170562002185	putative NAD(P) binding site [chemical binding]; other site
1170562002186	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1170562002187	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1170562002188	salt bridge; other site
1170562002189	non-specific DNA binding site [nucleotide binding]; other site
1170562002190	sequence-specific DNA binding site [nucleotide binding]; other site
1170562002191	pyruvate dehydrogenase E1 component beta subunit; Validated; Region: odpB; CHL00144
1170562002192	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1170562002193	alpha subunit interface [polypeptide binding]; other site
1170562002194	TPP binding site [chemical binding]; other site
1170562002195	heterodimer interface [polypeptide binding]; other site
1170562002196	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1170562002197	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
1170562002198	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1170562002199	active site
1170562002200	dimer interface [polypeptide binding]; other site
1170562002201	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
1170562002202	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1170562002203	active site
1170562002204	catalytic tetrad [active]
1170562002205	Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249
1170562002206	GTP/Mg2+ binding site [chemical binding]; other site
1170562002207	G4 box; other site
1170562002208	G5 box; other site
1170562002209	Predicted GTPase [General function prediction only]; Region: COG3596
1170562002210	YfjP GTPase; Region: YfjP; cd11383
1170562002211	G1 box; other site
1170562002212	G1 box; other site
1170562002213	GTP/Mg2+ binding site [chemical binding]; other site
1170562002214	Switch I region; other site
1170562002215	Switch I region; other site
1170562002216	G2 box; other site
1170562002217	G2 box; other site
1170562002218	Switch II region; other site
1170562002219	G3 box; other site
1170562002220	G3 box; other site
1170562002221	Switch II region; other site
1170562002222	G4 box; other site
1170562002223	AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911
1170562002224	Cytochrome c; Region: Cytochrom_C; cl11414
1170562002225	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1170562002226	Domain of unknown function (DUF4213); Region: DUF4213; pfam13938
1170562002227	Domain of unknown function (DUF364); Region: DUF364; pfam04016
1170562002228	Protein of unknown function (DUF2854); Region: DUF2854; pfam11016
1170562002229	CbbX; Provisional; Region: cbbX; CHL00181
1170562002230	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1170562002231	Walker A motif; other site
1170562002232	ATP binding site [chemical binding]; other site
1170562002233	Walker B motif; other site
1170562002234	arginine finger; other site
1170562002235	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562002236	ATP binding site [chemical binding]; other site
1170562002237	Mg2+ binding site [ion binding]; other site
1170562002238	G-X-G motif; other site
1170562002239	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
1170562002240	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
1170562002241	Protein of unknown function (DUF2839); Region: DUF2839; pfam10999
1170562002242	Domain of unknown function (DUF1815); Region: DUF1815; pfam08844
1170562002243	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1170562002244	active site
1170562002245	Uncharacterized conserved protein [Function unknown]; Region: COG4301
1170562002246	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
1170562002247	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
1170562002248	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
1170562002249	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
1170562002250	Predicted membrane protein [Function unknown]; Region: COG3463
1170562002251	Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852
1170562002252	Predicted esterase [General function prediction only]; Region: COG0400
1170562002253	putative hydrolase; Provisional; Region: PRK11460
1170562002254	Protein of unknown function (DUF2555); Region: DUF2555; pfam10742
1170562002255	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
1170562002256	Flavoprotein; Region: Flavoprotein; pfam02441
1170562002257	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
1170562002258	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666
1170562002259	nudix motif; other site
1170562002260	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
1170562002261	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
1170562002262	putative active site [active]
1170562002263	putative dimer interface [polypeptide binding]; other site
1170562002264	NIL domain; Region: NIL; pfam09383
1170562002265	SprT homologues; Region: SprT; cl01182
1170562002266	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein; Provisional; Region: PRK09319
1170562002267	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
1170562002268	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
1170562002269	dimerization interface [polypeptide binding]; other site
1170562002270	active site
1170562002271	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
1170562002272	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1170562002273	PAS domain S-box; Region: sensory_box; TIGR00229
1170562002274	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562002275	putative active site [active]
1170562002276	heme pocket [chemical binding]; other site
1170562002277	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1170562002278	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1170562002279	metal binding site [ion binding]; metal-binding site
1170562002280	active site
1170562002281	I-site; other site
1170562002282	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
1170562002283	homooctamer interface [polypeptide binding]; other site
1170562002284	active site
1170562002285	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
1170562002286	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
1170562002287	dimer interface [polypeptide binding]; other site
1170562002288	tetramer interface [polypeptide binding]; other site
1170562002289	PYR/PP interface [polypeptide binding]; other site
1170562002290	TPP binding site [chemical binding]; other site
1170562002291	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
1170562002292	TPP-binding site; other site
1170562002293	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1170562002294	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
1170562002295	substrate binding site [chemical binding]; other site
1170562002296	oxyanion hole (OAH) forming residues; other site
1170562002297	trimer interface [polypeptide binding]; other site
1170562002298	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1170562002299	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
1170562002300	metal binding site [ion binding]; metal-binding site
1170562002301	dimer interface [polypeptide binding]; other site
1170562002302	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1170562002303	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1170562002304	Walker A/P-loop; other site
1170562002305	ATP binding site [chemical binding]; other site
1170562002306	Q-loop/lid; other site
1170562002307	ABC transporter signature motif; other site
1170562002308	Walker B; other site
1170562002309	D-loop; other site
1170562002310	H-loop/switch region; other site
1170562002311	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1170562002312	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1170562002313	Walker A/P-loop; other site
1170562002314	ATP binding site [chemical binding]; other site
1170562002315	Q-loop/lid; other site
1170562002316	ABC transporter signature motif; other site
1170562002317	Walker B; other site
1170562002318	D-loop; other site
1170562002319	H-loop/switch region; other site
1170562002320	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1170562002321	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
1170562002322	HD domain; Region: HD_4; pfam13328
1170562002323	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1170562002324	synthetase active site [active]
1170562002325	NTP binding site [chemical binding]; other site
1170562002326	metal binding site [ion binding]; metal-binding site
1170562002327	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1170562002328	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
1170562002329	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562002330	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1170562002331	putative active site [active]
1170562002332	heme pocket [chemical binding]; other site
1170562002333	PAS domain; Region: PAS; smart00091
1170562002334	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1170562002335	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562002336	dimer interface [polypeptide binding]; other site
1170562002337	phosphorylation site [posttranslational modification]
1170562002338	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562002339	ATP binding site [chemical binding]; other site
1170562002340	Mg2+ binding site [ion binding]; other site
1170562002341	G-X-G motif; other site
1170562002342	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
1170562002343	dimer interface [polypeptide binding]; other site
1170562002344	[2Fe-2S] cluster binding site [ion binding]; other site
1170562002345	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1848
1170562002346	putative active site [active]
1170562002347	Uncharacterized conserved protein [Function unknown]; Region: COG0062
1170562002348	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
1170562002349	putative substrate binding site [chemical binding]; other site
1170562002350	putative ATP binding site [chemical binding]; other site
1170562002351	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
1170562002352	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
1170562002353	ATP binding site [chemical binding]; other site
1170562002354	Mg2+ binding site [ion binding]; other site
1170562002355	G-X-G motif; other site
1170562002356	TRAM domain; Region: TRAM; cl01282
1170562002357	23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479
1170562002358	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1170562002359	S-adenosylmethionine binding site [chemical binding]; other site
1170562002360	Phycobilisome protein; Region: Phycobilisome; cl08227
1170562002361	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3502
1170562002362	TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012
1170562002363	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1170562002364	catalytic residues [active]
1170562002365	photosystem I P700 chlorophyll a apoprotein A1; Region: psaA; CHL00056
1170562002366	photosystem I P700 chlorophyll a apoprotein A2; Provisional; Region: psaB; PRK13199
1170562002367	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1170562002368	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1170562002369	Ankyrin repeats (many copies); Region: Ank_5; pfam13857
1170562002370	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1170562002371	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1170562002372	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1170562002373	GUN4-like; Region: GUN4; pfam05419
1170562002374	phosphoglucomutase; Region: PLN02307
1170562002375	Phosphoglucomutase 1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P) via a glucose 1,6-diphosphate intermediate, an important metabolic step in prokaryotes and eukaryotes. In one direction; Region: PGM1; cd03085
1170562002376	substrate binding site [chemical binding]; other site
1170562002377	dimer interface [polypeptide binding]; other site
1170562002378	active site
1170562002379	metal binding site [ion binding]; metal-binding site
1170562002380	Protein of unknown function (DUF760); Region: DUF760; pfam05542
1170562002381	Photosystem II protein; Region: PSII; cl08223
1170562002382	chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041
1170562002383	Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG3372
1170562002384	Protein of unknown function (DUF790); Region: DUF790; pfam05626
1170562002385	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
1170562002386	30S subunit binding site; other site
1170562002387	Lipoate-protein ligase B [Coenzyme metabolism]; Region: LipB; COG0321
1170562002388	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
1170562002389	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
1170562002390	putative active site [active]
1170562002391	Protein of unknown function (DUF3239); Region: DUF3239; pfam11580
1170562002392	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1170562002393	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1170562002394	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
1170562002395	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
1170562002396	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1170562002397	active site
1170562002398	metal binding site [ion binding]; metal-binding site
1170562002399	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
1170562002400	Peptidase family M48; Region: Peptidase_M48; pfam01435
1170562002401	Domain of unknown function (DUF4330); Region: DUF4330; pfam14221
1170562002402	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
1170562002403	catalytic triad [active]
1170562002404	dimer interface [polypeptide binding]; other site
1170562002405	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1170562002406	Manganese-stabilising protein / photosystem II polypeptide; Region: MSP; pfam01716
1170562002407	RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408
1170562002408	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1170562002409	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1170562002410	DNA binding residues [nucleotide binding]
1170562002411	photosystem I subunit VIII; Validated; Region: psaI; CHL00186
1170562002412	photosystem II reaction center protein J; Provisional; Region: PRK02565
1170562002413	photosystem II reaction center L; Provisional; Region: psbL; PRK00753
1170562002414	cytochrome b559 subunit beta; Provisional; Region: psbF; PRK02561
1170562002415	cytochrome b559 subunit alpha; Provisional; Region: psbE; PRK02557
1170562002416	Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; pfam00283
1170562002417	Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit; Region: Cytochrom_B559a; pfam00284
1170562002418	Ycf48-like protein; Provisional; Region: PRK13684
1170562002419	N-terminal sub-domain of the Rel homology domain (RHD); Region: RHD-n; cl08275
1170562002420	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
1170562002421	Rubredoxin; Region: Rubredoxin; pfam00301
1170562002422	iron binding site [ion binding]; other site
1170562002423	NADH dehydrogenase subunit 3; Region: ndhC; CHL00022
1170562002424	NADH dehydrogenase subunit K; Region: ndhK; CHL00023
1170562002425	NADH dehydrogenase subunit J; Provisional; Region: PRK12494
1170562002426	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
1170562002427	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
1170562002428	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1170562002429	Phytochrome region; Region: PHY; pfam00360
1170562002430	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562002431	dimer interface [polypeptide binding]; other site
1170562002432	phosphorylation site [posttranslational modification]
1170562002433	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562002434	ATP binding site [chemical binding]; other site
1170562002435	Mg2+ binding site [ion binding]; other site
1170562002436	G-X-G motif; other site
1170562002437	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562002438	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562002439	active site
1170562002440	phosphorylation site [posttranslational modification]
1170562002441	intermolecular recognition site; other site
1170562002442	dimerization interface [polypeptide binding]; other site
1170562002443	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1170562002444	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562002445	active site
1170562002446	phosphorylation site [posttranslational modification]
1170562002447	intermolecular recognition site; other site
1170562002448	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1170562002449	dimerization interface [polypeptide binding]; other site
1170562002450	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562002451	dimer interface [polypeptide binding]; other site
1170562002452	phosphorylation site [posttranslational modification]
1170562002453	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562002454	ATP binding site [chemical binding]; other site
1170562002455	Mg2+ binding site [ion binding]; other site
1170562002456	G-X-G motif; other site
1170562002457	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306
1170562002458	active site
1170562002459	catalytic residues [active]
1170562002460	Domain of unknown function (DUF1817); Region: DUF1817; pfam08847
1170562002461	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
1170562002462	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1170562002463	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1170562002464	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
1170562002465	substrate binding site; other site
1170562002466	dimer interface; other site
1170562002467	Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612
1170562002468	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1170562002469	putative active site [active]
1170562002470	Protein of unknown function (DUF760); Region: DUF760; pfam05542
1170562002471	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1170562002472	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1170562002473	protein binding site [polypeptide binding]; other site
1170562002474	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1170562002475	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1170562002476	Peptidase family M23; Region: Peptidase_M23; pfam01551
1170562002477	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
1170562002478	Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471
1170562002479	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
1170562002480	active site
1170562002481	Glutamine amidotransferase domain; Region: GATase_6; pfam13522
1170562002482	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
1170562002483	Ligand Binding Site [chemical binding]; other site
1170562002484	Molecular Tunnel; other site
1170562002485	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270
1170562002486	active site
1170562002487	metal-binding site [ion binding]
1170562002488	nucleotide-binding site [chemical binding]; other site
1170562002489	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1170562002490	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1170562002491	Walker A/P-loop; other site
1170562002492	ATP binding site [chemical binding]; other site
1170562002493	Q-loop/lid; other site
1170562002494	ABC transporter signature motif; other site
1170562002495	Walker B; other site
1170562002496	D-loop; other site
1170562002497	H-loop/switch region; other site
1170562002498	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1170562002499	putative active site [active]
1170562002500	Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240
1170562002501	Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846
1170562002502	active site
1170562002503	catalytic triad [active]
1170562002504	oxyanion hole [active]
1170562002505	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
1170562002506	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
1170562002507	catalytic triad [active]
1170562002508	conserved cis-peptide bond; other site
1170562002509	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
1170562002510	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1170562002511	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1170562002512	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
1170562002513	C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567
1170562002514	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
1170562002515	protein binding site [polypeptide binding]; other site
1170562002516	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
1170562002517	Catalytic dyad [active]
1170562002518	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1170562002519	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1170562002520	active site
1170562002521	ATP binding site [chemical binding]; other site
1170562002522	substrate binding site [chemical binding]; other site
1170562002523	activation loop (A-loop); other site
1170562002524	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1170562002525	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562002526	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562002527	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1170562002528	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1170562002529	phosphopeptide binding site; other site
1170562002530	recombinase A; Provisional; Region: recA; PRK09354
1170562002531	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
1170562002532	hexamer interface [polypeptide binding]; other site
1170562002533	Walker A motif; other site
1170562002534	ATP binding site [chemical binding]; other site
1170562002535	Walker B motif; other site
1170562002536	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
1170562002537	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1170562002538	catalytic loop [active]
1170562002539	iron binding site [ion binding]; other site
1170562002540	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1170562002541	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1170562002542	Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538
1170562002543	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
1170562002544	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
1170562002545	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
1170562002546	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
1170562002547	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1170562002548	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1170562002549	P-loop; other site
1170562002550	Magnesium ion binding site [ion binding]; other site
1170562002551	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
1170562002552	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
1170562002553	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
1170562002554	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
1170562002555	generic binding surface II; other site
1170562002556	ssDNA binding site; other site
1170562002557	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1170562002558	ATP binding site [chemical binding]; other site
1170562002559	putative Mg++ binding site [ion binding]; other site
1170562002560	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1170562002561	nucleotide binding region [chemical binding]; other site
1170562002562	ATP-binding site [chemical binding]; other site
1170562002563	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1170562002564	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1170562002565	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1170562002566	Walker A/P-loop; other site
1170562002567	ATP binding site [chemical binding]; other site
1170562002568	Q-loop/lid; other site
1170562002569	ABC transporter signature motif; other site
1170562002570	Walker B; other site
1170562002571	D-loop; other site
1170562002572	H-loop/switch region; other site
1170562002573	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
1170562002574	plastocyanin; Provisional; Region: PRK02710
1170562002575	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
1170562002576	cytochrome c-550; Provisional; Region: psbV; PRK13618
1170562002577	pheophorbide a oxygenase; Region: PLN02518
1170562002578	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
1170562002579	iron-sulfur cluster [ion binding]; other site
1170562002580	[2Fe-2S] cluster binding site [ion binding]; other site
1170562002581	Pheophorbide a oxygenase; Region: PaO; pfam08417
1170562002582	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
1170562002583	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
1170562002584	active site
1170562002585	HIGH motif; other site
1170562002586	dimer interface [polypeptide binding]; other site
1170562002587	KMSKS motif; other site
1170562002588	Predicted ATPase [General function prediction only]; Region: COG4637
1170562002589	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1170562002590	Walker A/P-loop; other site
1170562002591	ATP binding site [chemical binding]; other site
1170562002592	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1170562002593	ABC transporter signature motif; other site
1170562002594	Walker B; other site
1170562002595	D-loop; other site
1170562002596	H-loop/switch region; other site
1170562002597	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1170562002598	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1170562002599	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1170562002600	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
1170562002601	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1170562002602	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
1170562002603	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
1170562002604	Peptidase family M41; Region: Peptidase_M41; pfam01434
1170562002605	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1170562002606	metal binding site [ion binding]; metal-binding site
1170562002607	active site
1170562002608	I-site; other site
1170562002609	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
1170562002610	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
1170562002611	motif 1; other site
1170562002612	active site
1170562002613	motif 2; other site
1170562002614	motif 3; other site
1170562002615	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1170562002616	DHHA1 domain; Region: DHHA1; pfam02272
1170562002617	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
1170562002618	putative active site [active]
1170562002619	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1170562002620	putative active site [active]
1170562002621	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
1170562002622	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
1170562002623	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
1170562002624	GxxExxY protein; Region: GxxExxY; TIGR04256
1170562002625	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
1170562002626	haemagglutination activity domain; Region: Haemagg_act; pfam05860
1170562002627	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
1170562002628	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
1170562002629	MltA specific insert domain; Region: MltA; pfam03562
1170562002630	3D domain; Region: 3D; pfam06725
1170562002631	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1170562002632	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
1170562002633	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
1170562002634	UreF; Region: UreF; pfam01730
1170562002635	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
1170562002636	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
1170562002637	dimer interface [polypeptide binding]; other site
1170562002638	catalytic residues [active]
1170562002639	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
1170562002640	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
1170562002641	active site
1170562002642	metal binding site [ion binding]; metal-binding site
1170562002643	DNA binding site [nucleotide binding]
1170562002644	PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595
1170562002645	PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595
1170562002646	Protein of unknown function (DUF938); Region: DUF938; pfam06080
1170562002647	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1170562002648	classical (c) SDRs; Region: SDR_c; cd05233
1170562002649	NAD(P) binding site [chemical binding]; other site
1170562002650	active site
1170562002651	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
1170562002652	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075
1170562002653	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
1170562002654	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1170562002655	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1170562002656	anti sigma factor interaction site; other site
1170562002657	regulatory phosphorylation site [posttranslational modification]; other site
1170562002658	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1170562002659	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1170562002660	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1170562002661	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
1170562002662	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1170562002663	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
1170562002664	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1170562002665	motif II; other site
1170562002666	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1170562002667	recombination protein F; Reviewed; Region: recF; PRK00064
1170562002668	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
1170562002669	Walker A/P-loop; other site
1170562002670	ATP binding site [chemical binding]; other site
1170562002671	Q-loop/lid; other site
1170562002672	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1170562002673	ABC transporter signature motif; other site
1170562002674	Walker B; other site
1170562002675	D-loop; other site
1170562002676	H-loop/switch region; other site
1170562002677	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
1170562002678	MgtC family; Region: MgtC; pfam02308
1170562002679	phosphoenolpyruvate synthase; Region: PEP_synth; TIGR01418
1170562002680	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
1170562002681	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1170562002682	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1170562002683	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1170562002684	Archaeal ATPase; Region: Arch_ATPase; pfam01637
1170562002685	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562002686	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562002687	binding surface
1170562002688	TPR motif; other site
1170562002689	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562002690	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562002691	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562002692	binding surface
1170562002693	TPR motif; other site
1170562002694	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562002695	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562002696	binding surface
1170562002697	TPR motif; other site
1170562002698	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562002699	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
1170562002700	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
1170562002701	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1170562002702	Cytochrome P450; Region: p450; cl12078
1170562002703	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1170562002704	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1170562002705	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1170562002706	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
1170562002707	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1170562002708	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
1170562002709	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
1170562002710	thiopurine S-methyltransferase, Se/Te detoxification family; Region: TMPT_Se_Te; TIGR03840
1170562002711	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1170562002712	S-adenosylmethionine binding site [chemical binding]; other site
1170562002713	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
1170562002714	putative acyl-acceptor binding pocket; other site
1170562002715	prolyl-tRNA synthetase; Provisional; Region: PRK09194
1170562002716	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
1170562002717	dimer interface [polypeptide binding]; other site
1170562002718	motif 1; other site
1170562002719	active site
1170562002720	motif 2; other site
1170562002721	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
1170562002722	putative deacylase active site [active]
1170562002723	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1170562002724	active site
1170562002725	motif 3; other site
1170562002726	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
1170562002727	anticodon binding site; other site
1170562002728	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1170562002729	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1170562002730	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1170562002731	Walker A/P-loop; other site
1170562002732	ATP binding site [chemical binding]; other site
1170562002733	Q-loop/lid; other site
1170562002734	ABC transporter signature motif; other site
1170562002735	Walker B; other site
1170562002736	D-loop; other site
1170562002737	H-loop/switch region; other site
1170562002738	Predicted transcriptional regulator [Transcription]; Region: COG1959
1170562002739	Transcriptional regulator; Region: Rrf2; cl17282
1170562002740	DDE superfamily endonuclease; Region: DDE_5; cl17874
1170562002741	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1170562002742	AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250
1170562002743	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
1170562002744	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
1170562002745	Cl- selectivity filter; other site
1170562002746	Cl- binding residues [ion binding]; other site
1170562002747	pore gating glutamate residue; other site
1170562002748	dimer interface [polypeptide binding]; other site
1170562002749	FOG: CBS domain [General function prediction only]; Region: COG0517
1170562002750	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in bacteria and archaea. These ion channels are proteins with a seemingly simple task of allowing the passive flow of...; Region: CBS_pair_EriC_assoc_bac_arch; cd04593
1170562002751	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
1170562002752	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
1170562002753	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1170562002754	Resolvase, N terminal domain; Region: Resolvase; smart00857
1170562002755	catalytic residues [active]
1170562002756	Recombinase; Region: Recombinase; pfam07508
1170562002757	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
1170562002758	Domain of unknown function (DUF4327); Region: DUF4327; pfam14217
1170562002759	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562002760	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562002761	active site
1170562002762	phosphorylation site [posttranslational modification]
1170562002763	intermolecular recognition site; other site
1170562002764	dimerization interface [polypeptide binding]; other site
1170562002765	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
1170562002766	Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250
1170562002767	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494
1170562002768	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1170562002769	catalytic residue [active]
1170562002770	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
1170562002771	ABC1 family; Region: ABC1; cl17513
1170562002772	ABC1 family; Region: ABC1; cl17513
1170562002773	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
1170562002774	active site
1170562002775	Phycobilisome degradation protein nblA; Region: NblA; pfam04485
1170562002776	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1170562002777	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1170562002778	Coenzyme A binding pocket [chemical binding]; other site
1170562002779	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
1170562002780	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1170562002781	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
1170562002782	active site
1170562002783	oxo-acid-lyase/anthranilate synthase; Region: PLN02889
1170562002784	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1170562002785	glutamine binding [chemical binding]; other site
1170562002786	catalytic triad [active]
1170562002787	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1170562002788	chorismate binding enzyme; Region: Chorismate_bind; cl10555
1170562002789	TPR repeat; Region: TPR_11; pfam13414
1170562002790	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562002791	binding surface
1170562002792	TPR motif; other site
1170562002793	TPR repeat; Region: TPR_11; pfam13414
1170562002794	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562002795	binding surface
1170562002796	TPR motif; other site
1170562002797	TPR repeat; Region: TPR_11; pfam13414
1170562002798	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562002799	binding surface
1170562002800	TPR motif; other site
1170562002801	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1170562002802	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562002803	TPR motif; other site
1170562002804	binding surface
1170562002805	TPR repeat; Region: TPR_11; pfam13414
1170562002806	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
1170562002807	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
1170562002808	HflX GTPase family; Region: HflX; cd01878
1170562002809	G1 box; other site
1170562002810	GTP/Mg2+ binding site [chemical binding]; other site
1170562002811	Switch I region; other site
1170562002812	G2 box; other site
1170562002813	G3 box; other site
1170562002814	Switch II region; other site
1170562002815	G4 box; other site
1170562002816	G5 box; other site
1170562002817	TPR repeat; Region: TPR_11; pfam13414
1170562002818	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562002819	binding surface
1170562002820	TPR motif; other site
1170562002821	TPR repeat; Region: TPR_11; pfam13414
1170562002822	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562002823	binding surface
1170562002824	TPR motif; other site
1170562002825	TPR repeat; Region: TPR_11; pfam13414
1170562002826	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562002827	binding surface
1170562002828	TPR motif; other site
1170562002829	TPR repeat; Region: TPR_11; pfam13414
1170562002830	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562002831	binding surface
1170562002832	TPR repeat; Region: TPR_11; pfam13414
1170562002833	TPR motif; other site
1170562002834	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1170562002835	4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12870
1170562002836	UbiA prenyltransferase family; Region: UbiA; pfam01040
1170562002837	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
1170562002838	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
1170562002839	TPR repeat; Region: TPR_11; pfam13414
1170562002840	TPR repeat; Region: TPR_11; pfam13414
1170562002841	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562002842	binding surface
1170562002843	TPR motif; other site
1170562002844	TPR repeat; Region: TPR_11; pfam13414
1170562002845	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1170562002846	Protein of unknown function (DUF3110); Region: DUF3110; pfam11360
1170562002847	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
1170562002848	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
1170562002849	putative active site [active]
1170562002850	Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018
1170562002851	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
1170562002852	Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029
1170562002853	G1 box; other site
1170562002854	GTP/Mg2+ binding site [chemical binding]; other site
1170562002855	G2 box; other site
1170562002856	Switch I region; other site
1170562002857	G3 box; other site
1170562002858	Switch II region; other site
1170562002859	G4 box; other site
1170562002860	G5 box; other site
1170562002861	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
1170562002862	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562002863	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562002864	active site
1170562002865	phosphorylation site [posttranslational modification]
1170562002866	intermolecular recognition site; other site
1170562002867	dimerization interface [polypeptide binding]; other site
1170562002868	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1170562002869	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562002870	active site
1170562002871	phosphorylation site [posttranslational modification]
1170562002872	intermolecular recognition site; other site
1170562002873	dimerization interface [polypeptide binding]; other site
1170562002874	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
1170562002875	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1170562002876	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1170562002877	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1170562002878	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1170562002879	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1170562002880	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1170562002881	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1170562002882	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1170562002883	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1170562002884	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1170562002885	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1170562002886	GAF domain; Region: GAF; pfam01590
1170562002887	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1170562002888	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1170562002889	dimer interface [polypeptide binding]; other site
1170562002890	putative CheW interface [polypeptide binding]; other site
1170562002891	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1170562002892	putative binding surface; other site
1170562002893	active site
1170562002894	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
1170562002895	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562002896	ATP binding site [chemical binding]; other site
1170562002897	Mg2+ binding site [ion binding]; other site
1170562002898	G-X-G motif; other site
1170562002899	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
1170562002900	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562002901	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562002902	active site
1170562002903	phosphorylation site [posttranslational modification]
1170562002904	intermolecular recognition site; other site
1170562002905	dimerization interface [polypeptide binding]; other site
1170562002906	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1170562002907	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
1170562002908	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1170562002909	Domon-like domain of UDP-N-acetylenolpyruvoylglucosamine reductase; Region: DOMON_murB_like; cd09627
1170562002910	putative heme binding site [chemical binding]; other site
1170562002911	Phosphotransferase enzyme family; Region: APH; pfam01636
1170562002912	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1170562002913	substrate binding site [chemical binding]; other site
1170562002914	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
1170562002915	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1170562002916	Peptidase family M23; Region: Peptidase_M23; pfam01551
1170562002917	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562002918	TPR motif; other site
1170562002919	binding surface
1170562002920	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
1170562002921	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1170562002922	ATP binding site [chemical binding]; other site
1170562002923	Walker B motif; other site
1170562002924	arginine finger; other site
1170562002925	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
1170562002926	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
1170562002927	Predicted permeases [General function prediction only]; Region: COG0679
1170562002928	S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687
1170562002929	XisH protein; Region: XisH; pfam08814
1170562002930	XisI protein; Region: XisI; pfam08869
1170562002931	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1170562002932	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
1170562002933	putative ADP-binding pocket [chemical binding]; other site
1170562002934	Mitochondrial fission regulator; Region: Mito_fiss_reg; pfam05308
1170562002935	HEAT repeats; Region: HEAT_2; pfam13646
1170562002936	HEAT repeats; Region: HEAT_2; pfam13646
1170562002937	HEAT repeats; Region: HEAT_2; pfam13646
1170562002938	Protein of unknown function (DUF456); Region: DUF456; cl01069
1170562002939	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1170562002940	dimerization interface [polypeptide binding]; other site
1170562002941	putative DNA binding site [nucleotide binding]; other site
1170562002942	putative Zn2+ binding site [ion binding]; other site
1170562002943	Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; cl01589
1170562002944	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360
1170562002945	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
1170562002946	Substrate binding site; other site
1170562002947	Mg++ binding site; other site
1170562002948	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
1170562002949	active site
1170562002950	substrate binding site [chemical binding]; other site
1170562002951	CoA binding site [chemical binding]; other site
1170562002952	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
1170562002953	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562002954	active site
1170562002955	phosphorylation site [posttranslational modification]
1170562002956	intermolecular recognition site; other site
1170562002957	dimerization interface [polypeptide binding]; other site
1170562002958	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1170562002959	Zn2+ binding site [ion binding]; other site
1170562002960	Mg2+ binding site [ion binding]; other site
1170562002961	S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; pfam05430
1170562002962	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
1170562002963	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
1170562002964	active site residue [active]
1170562002965	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
1170562002966	active site residue [active]
1170562002967	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
1170562002968	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
1170562002969	N- and C-terminal domain interface [polypeptide binding]; other site
1170562002970	active site
1170562002971	MgATP binding site [chemical binding]; other site
1170562002972	catalytic site [active]
1170562002973	metal binding site [ion binding]; metal-binding site
1170562002974	glycerol binding site [chemical binding]; other site
1170562002975	homotetramer interface [polypeptide binding]; other site
1170562002976	homodimer interface [polypeptide binding]; other site
1170562002977	FBP binding site [chemical binding]; other site
1170562002978	protein IIAGlc interface [polypeptide binding]; other site
1170562002979	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1170562002980	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1170562002981	dimer interface [polypeptide binding]; other site
1170562002982	conserved gate region; other site
1170562002983	putative PBP binding loops; other site
1170562002984	ABC-ATPase subunit interface; other site
1170562002985	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212
1170562002986	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
1170562002987	Phycobilisome degradation protein nblA; Region: NblA; pfam04485
1170562002988	CpeS-like protein; Region: CpeS; pfam09367
1170562002989	CpeS-like protein; Region: CpeS; pfam09367
1170562002990	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562002991	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1170562002992	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562002993	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562002994	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1170562002995	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562002996	HEAT repeats; Region: HEAT_2; pfam13646
1170562002997	HEAT repeats; Region: HEAT_2; pfam13646
1170562002998	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020
1170562002999	protein binding surface [polypeptide binding]; other site
1170562003000	HEAT repeats; Region: HEAT_2; pfam13646
1170562003001	HEAT repeats; Region: HEAT_2; pfam13646
1170562003002	HEAT repeats; Region: HEAT_2; pfam13646
1170562003003	HEAT repeats; Region: HEAT_2; pfam13646
1170562003004	HEAT repeats; Region: HEAT_2; pfam13646
1170562003005	Phycobilisome protein; Region: Phycobilisome; cl08227
1170562003006	Phycobilisome protein; Region: Phycobilisome; cl08227
1170562003007	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
1170562003008	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
1170562003009	valyl-tRNA synthetase; Region: valS; TIGR00422
1170562003010	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1170562003011	HIGH motif; other site
1170562003012	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1170562003013	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1170562003014	active site
1170562003015	KMSKS motif; other site
1170562003016	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
1170562003017	tRNA binding surface [nucleotide binding]; other site
1170562003018	anticodon binding site; other site
1170562003019	Domain of unknown function (DUF4308); Region: DUF4308; pfam14159
1170562003020	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
1170562003021	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
1170562003022	FAD binding site [chemical binding]; other site
1170562003023	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1170562003024	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1170562003025	nudix motif; other site
1170562003026	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1170562003027	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
1170562003028	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1170562003029	hypothetical protein; Provisional; Region: PRK07394
1170562003030	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1170562003031	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1170562003032	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1170562003033	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1170562003034	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1170562003035	dimerization interface [polypeptide binding]; other site
1170562003036	HEAT repeats; Region: HEAT_2; pfam13646
1170562003037	HEAT repeats; Region: HEAT_2; pfam13646
1170562003038	HEAT repeats; Region: HEAT_2; pfam13646
1170562003039	HEAT repeats; Region: HEAT_2; pfam13646
1170562003040	ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566
1170562003041	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1170562003042	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1170562003043	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1170562003044	NMT1-like family; Region: NMT1_2; pfam13379
1170562003045	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1170562003046	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1170562003047	dimer interface [polypeptide binding]; other site
1170562003048	conserved gate region; other site
1170562003049	putative PBP binding loops; other site
1170562003050	ABC-ATPase subunit interface; other site
1170562003051	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1170562003052	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
1170562003053	Walker A/P-loop; other site
1170562003054	ATP binding site [chemical binding]; other site
1170562003055	Q-loop/lid; other site
1170562003056	ABC transporter signature motif; other site
1170562003057	Walker B; other site
1170562003058	D-loop; other site
1170562003059	H-loop/switch region; other site
1170562003060	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1170562003061	NMT1-like family; Region: NMT1_2; pfam13379
1170562003062	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1170562003063	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
1170562003064	Walker A/P-loop; other site
1170562003065	ATP binding site [chemical binding]; other site
1170562003066	Q-loop/lid; other site
1170562003067	ABC transporter signature motif; other site
1170562003068	Walker B; other site
1170562003069	D-loop; other site
1170562003070	H-loop/switch region; other site
1170562003071	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
1170562003072	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
1170562003073	[4Fe-4S] binding site [ion binding]; other site
1170562003074	molybdopterin cofactor binding site; other site
1170562003075	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
1170562003076	molybdopterin cofactor binding site; other site
1170562003077	Predicted membrane protein [Function unknown]; Region: COG3431
1170562003078	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
1170562003079	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
1170562003080	homodimer interface [polypeptide binding]; other site
1170562003081	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1170562003082	catalytic residue [active]
1170562003083	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1170562003084	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1170562003085	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1170562003086	Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604
1170562003087	TPR repeat; Region: TPR_11; pfam13414
1170562003088	TPR repeat; Region: TPR_11; pfam13414
1170562003089	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562003090	binding surface
1170562003091	TPR motif; other site
1170562003092	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1170562003093	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562003094	binding surface
1170562003095	TPR motif; other site
1170562003096	TPR repeat; Region: TPR_11; pfam13414
1170562003097	cytochrome c6; Provisional; Region: PRK13697
1170562003098	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5381
1170562003099	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1170562003100	anti sigma factor interaction site; other site
1170562003101	regulatory phosphorylation site [posttranslational modification]; other site
1170562003102	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
1170562003103	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
1170562003104	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
1170562003105	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
1170562003106	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
1170562003107	F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13450
1170562003108	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
1170562003109	gamma subunit interface [polypeptide binding]; other site
1170562003110	epsilon subunit interface [polypeptide binding]; other site
1170562003111	LBP interface [polypeptide binding]; other site
1170562003112	ATP synthase CF1 beta subunit; Region: atpB; CHL00060
1170562003113	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1170562003114	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
1170562003115	alpha subunit interaction interface [polypeptide binding]; other site
1170562003116	Walker A motif; other site
1170562003117	ATP binding site [chemical binding]; other site
1170562003118	Walker B motif; other site
1170562003119	inhibitor binding site; inhibition site
1170562003120	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1170562003121	Uncharacterized conserved protein [Function unknown]; Region: COG2912
1170562003122	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
1170562003123	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562003124	binding surface
1170562003125	TPR motif; other site
1170562003126	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1170562003127	active site
1170562003128	3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043
1170562003129	Transcriptional regulator [Transcription]; Region: LytR; COG1316
1170562003130	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
1170562003131	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1170562003132	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1170562003133	SERine Proteinase INhibitors (serpins), prokaryotic subgroup. Little information about specific functions is available for this subgroup, most likely they are inhibitory members of the serpin superfamily. In general, serpins exhibit conformational...; Region: bacterial_SERPIN; cd02049
1170562003134	reactive center loop; other site
1170562003135	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1170562003136	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
1170562003137	Probable transposase; Region: OrfB_IS605; pfam01385
1170562003138	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
1170562003139	photochlorophyllide reductase subunit B; Region: chlB; CHL00076
1170562003140	Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981
1170562003141	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
1170562003142	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
1170562003143	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562003144	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562003145	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
1170562003146	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1170562003147	HlyD family secretion protein; Region: HlyD_3; pfam13437
1170562003148	DevC protein; Region: devC; TIGR01185
1170562003149	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1170562003150	FtsX-like permease family; Region: FtsX; pfam02687
1170562003151	ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982
1170562003152	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1170562003153	Walker A/P-loop; other site
1170562003154	ATP binding site [chemical binding]; other site
1170562003155	Q-loop/lid; other site
1170562003156	ABC transporter signature motif; other site
1170562003157	Walker B; other site
1170562003158	D-loop; other site
1170562003159	H-loop/switch region; other site
1170562003160	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
1170562003161	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1170562003162	catalytic triad [active]
1170562003163	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1170562003164	ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494
1170562003165	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1170562003166	motif II; other site
1170562003167	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
1170562003168	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1170562003169	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
1170562003170	oligomeric interface; other site
1170562003171	putative active site [active]
1170562003172	Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
1170562003173	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1170562003174	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1170562003175	active site
1170562003176	ATP binding site [chemical binding]; other site
1170562003177	substrate binding site [chemical binding]; other site
1170562003178	activation loop (A-loop); other site
1170562003179	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
1170562003180	structural tetrad; other site
1170562003181	PQQ-like domain; Region: PQQ_2; pfam13360
1170562003182	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1170562003183	S-adenosylmethionine binding site [chemical binding]; other site
1170562003184	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
1170562003185	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1170562003186	motif II; other site
1170562003187	arginine decarboxylase; Provisional; Region: PRK05354
1170562003188	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
1170562003189	dimer interface [polypeptide binding]; other site
1170562003190	active site
1170562003191	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1170562003192	catalytic residues [active]
1170562003193	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
1170562003194	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
1170562003195	active site
1170562003196	multimer interface [polypeptide binding]; other site
1170562003197	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
1170562003198	shikimate kinase; Reviewed; Region: aroK; PRK00131
1170562003199	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
1170562003200	ADP binding site [chemical binding]; other site
1170562003201	magnesium binding site [ion binding]; other site
1170562003202	putative shikimate binding site; other site
1170562003203	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562003204	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1170562003205	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562003206	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562003207	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1170562003208	NACHT domain; Region: NACHT; pfam05729
1170562003209	Protein of unknown function (DUF1049); Region: DUF1049; pfam06305
1170562003210	aromatic acid decarboxylase; Validated; Region: PRK05920
1170562003211	Flavoprotein; Region: Flavoprotein; pfam02441
1170562003212	Exoribonuclease R [Transcription]; Region: VacB; COG0557
1170562003213	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
1170562003214	RNB domain; Region: RNB; pfam00773
1170562003215	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
1170562003216	RNA binding site [nucleotide binding]; other site
1170562003217	Clp protease; Region: CLP_protease; pfam00574
1170562003218	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1170562003219	oligomer interface [polypeptide binding]; other site
1170562003220	active site residues [active]
1170562003221	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
1170562003222	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
1170562003223	GTP binding site; other site
1170562003224	acetohydroxyacid synthase small subunit; Region: ilvH; CHL00100
1170562003225	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
1170562003226	putative valine binding site [chemical binding]; other site
1170562003227	dimer interface [polypeptide binding]; other site
1170562003228	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
1170562003229	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
1170562003230	CoA binding domain; Region: CoA_binding; cl17356
1170562003231	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
1170562003232	NAD(P) binding site [chemical binding]; other site
1170562003233	homodimer interface [polypeptide binding]; other site
1170562003234	substrate binding site [chemical binding]; other site
1170562003235	active site
1170562003236	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
1170562003237	MviN-like protein; Region: MVIN; pfam03023
1170562003238	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1170562003239	This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820
1170562003240	putative ADP-binding pocket [chemical binding]; other site
1170562003241	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1170562003242	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
1170562003243	putative ADP-binding pocket [chemical binding]; other site
1170562003244	type III secretion protein, YscU/HrpY family; Region: FlhB_rel_III; TIGR01404
1170562003245	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1170562003246	This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807
1170562003247	putative ADP-binding pocket [chemical binding]; other site
1170562003248	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1170562003249	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
1170562003250	putative ADP-binding pocket [chemical binding]; other site
1170562003251	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1170562003252	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
1170562003253	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
1170562003254	putative trimer interface [polypeptide binding]; other site
1170562003255	putative CoA binding site [chemical binding]; other site
1170562003256	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721
1170562003257	FemAB family; Region: FemAB; pfam02388
1170562003258	aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181
1170562003259	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1170562003260	inhibitor-cofactor binding pocket; inhibition site
1170562003261	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1170562003262	catalytic residue [active]
1170562003263	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
1170562003264	Chain length determinant protein; Region: Wzz; pfam02706
1170562003265	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
1170562003266	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
1170562003267	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1170562003268	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
1170562003269	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
1170562003270	putative active site [active]
1170562003271	Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576
1170562003272	Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576
1170562003273	Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576
1170562003274	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
1170562003275	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272
1170562003276	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1170562003277	putative NAD(P) binding site [chemical binding]; other site
1170562003278	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1170562003279	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1170562003280	putative PBP binding loops; other site
1170562003281	dimer interface [polypeptide binding]; other site
1170562003282	ABC-ATPase subunit interface; other site
1170562003283	AAA ATPase domain; Region: AAA_16; pfam13191
1170562003284	Iguana/Dzip1-like DAZ-interacting protein N-terminal; Region: Dzip-like_N; pfam13815
1170562003285	FOG: WD40 repeat [General function prediction only]; Region: COG2319
1170562003286	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
1170562003287	structural tetrad; other site
1170562003288	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
1170562003289	structural tetrad; other site
1170562003290	Eukaryotic translation initiation factor eIF2A; Region: eIF2A; pfam08662
1170562003291	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
1170562003292	Sec-independent translocase component C; Provisional; Region: tatC; CHL00182
1170562003293	Protein of unknown function (DUF3067); Region: DUF3067; pfam11267
1170562003294	cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474
1170562003295	Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802
1170562003296	Iron-sulfur protein (ISP) component of the b6f complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The cytochrome b6f complex from Mastigocladus laminosus, a thermophilic cyanobacterium; Region: Rieske_cytochrome_b6f; cd03471
1170562003297	cytochrome b subunit interaction site [polypeptide binding]; other site
1170562003298	[2Fe-2S] cluster binding site [ion binding]; other site
1170562003299	cytochrome f; Region: petA; CHL00037
1170562003300	apocytochrome f; Reviewed; Region: PRK02693
1170562003301	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
1170562003302	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1170562003303	Walker A motif; other site
1170562003304	ATP binding site [chemical binding]; other site
1170562003305	Walker B motif; other site
1170562003306	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562003307	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562003308	active site
1170562003309	phosphorylation site [posttranslational modification]
1170562003310	intermolecular recognition site; other site
1170562003311	dimerization interface [polypeptide binding]; other site
1170562003312	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
1170562003313	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1170562003314	active site residue [active]
1170562003315	Protein of unknown function (DUF3122); Region: DUF3122; pfam11320
1170562003316	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
1170562003317	Fasciclin domain; Region: Fasciclin; pfam02469
1170562003318	Phycobilisome degradation protein nblA; Region: NblA; pfam04485
1170562003319	light-harvesting-like protein 3; Provisional; Region: PLN00014
1170562003320	Phycobilisome protein; Region: Phycobilisome; cl08227
1170562003321	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1170562003322	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1170562003323	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1170562003324	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1170562003325	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1170562003326	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1170562003327	photosystem II reaction center protein Z; Provisional; Region: psbZ; PRK02576
1170562003328	FOG: CBS domain [General function prediction only]; Region: COG0517
1170562003329	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595
1170562003330	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1170562003331	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
1170562003332	active site
1170562003333	NTP binding site [chemical binding]; other site
1170562003334	metal binding triad [ion binding]; metal-binding site
1170562003335	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1170562003336	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
1170562003337	putative acyl-acceptor binding pocket; other site
1170562003338	Protein of unknown function (DUF1350); Region: DUF1350; pfam07082
1170562003339	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562003340	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562003341	active site
1170562003342	phosphorylation site [posttranslational modification]
1170562003343	intermolecular recognition site; other site
1170562003344	dimerization interface [polypeptide binding]; other site
1170562003345	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
1170562003346	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
1170562003347	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
1170562003348	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1170562003349	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562003350	active site
1170562003351	phosphorylation site [posttranslational modification]
1170562003352	intermolecular recognition site; other site
1170562003353	dimerization interface [polypeptide binding]; other site
1170562003354	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1170562003355	DNA binding site [nucleotide binding]
1170562003356	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
1170562003357	ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]; Region: APA2; COG4360
1170562003358	ATP adenylyltransferase; Region: ATP_transf; pfam09830
1170562003359	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660
1170562003360	phosphoenolpyruvate synthase; Validated; Region: PRK06241
1170562003361	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
1170562003362	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1170562003363	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
1170562003364	catalytic triad [active]
1170562003365	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
1170562003366	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02812
1170562003367	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1170562003368	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1170562003369	active site
1170562003370	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1170562003371	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1170562003372	active site
1170562003373	ATP binding site [chemical binding]; other site
1170562003374	substrate binding site [chemical binding]; other site
1170562003375	activation loop (A-loop); other site
1170562003376	AAA domain; Region: AAA_26; pfam13500
1170562003377	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
1170562003378	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
1170562003379	S-formylglutathione hydrolase; Region: PLN02442
1170562003380	Protein of unknown function (DUF2949); Region: DUF2949; pfam11165
1170562003381	trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858
1170562003382	Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939
1170562003383	active site
1170562003384	catalytic residues [active]
1170562003385	metal binding site [ion binding]; metal-binding site
1170562003386	NifZ domain; Region: NifZ; pfam04319
1170562003387	NifT/FixU protein; Region: NifT; pfam06988
1170562003388	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
1170562003389	dimer interface [polypeptide binding]; other site
1170562003390	[2Fe-2S] cluster binding site [ion binding]; other site
1170562003391	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
1170562003392	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562003393	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
1170562003394	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
1170562003395	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1170562003396	ATP binding site [chemical binding]; other site
1170562003397	putative Mg++ binding site [ion binding]; other site
1170562003398	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1170562003399	nucleotide binding region [chemical binding]; other site
1170562003400	ATP-binding site [chemical binding]; other site
1170562003401	Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550; cl17622
1170562003402	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
1170562003403	active site
1170562003404	NTP binding site [chemical binding]; other site
1170562003405	metal binding triad [ion binding]; metal-binding site
1170562003406	antibiotic binding site [chemical binding]; other site
1170562003407	Predicted type IV restriction endonuclease [Defense mechanisms]; Region: COG2810
1170562003408	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1170562003409	putative active site [active]
1170562003410	phosphate/phosphite/phosphonate ABC transporters, periplasmic binding protein; Region: 3A0109s03R; TIGR01098
1170562003411	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
1170562003412	substrate binding pocket [chemical binding]; other site
1170562003413	membrane-bound complex binding site; other site
1170562003414	hinge residues; other site
1170562003415	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
1170562003416	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1170562003417	Walker A/P-loop; other site
1170562003418	ATP binding site [chemical binding]; other site
1170562003419	Q-loop/lid; other site
1170562003420	ABC transporter signature motif; other site
1170562003421	Walker B; other site
1170562003422	D-loop; other site
1170562003423	H-loop/switch region; other site
1170562003424	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
1170562003425	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1170562003426	dimer interface [polypeptide binding]; other site
1170562003427	conserved gate region; other site
1170562003428	ABC-ATPase subunit interface; other site
1170562003429	Transposase domain (DUF772); Region: DUF772; pfam05598
1170562003430	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1170562003431	ABC-type uncharacterized transport system involved in gliding motility, auxiliary component [Cell motility and secretion]; Region: GldG; COG3225
1170562003432	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
1170562003433	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1170562003434	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1170562003435	Walker A/P-loop; other site
1170562003436	ATP binding site [chemical binding]; other site
1170562003437	Q-loop/lid; other site
1170562003438	ABC transporter signature motif; other site
1170562003439	Walker B; other site
1170562003440	D-loop; other site
1170562003441	H-loop/switch region; other site
1170562003442	Protein of unknown function (DUF2281); Region: DUF2281; pfam10047
1170562003443	Retropepsins; pepsin-like aspartate proteases; Region: retropepsin_like; cd00303
1170562003444	inhibitor binding site; inhibition site
1170562003445	catalytic motif [active]
1170562003446	Catalytic residue [active]
1170562003447	Active site flap [active]
1170562003448	Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403
1170562003449	inhibitor binding site; inhibition site
1170562003450	catalytic motif [active]
1170562003451	Catalytic residue [active]
1170562003452	Active site flap [active]
1170562003453	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1170562003454	S-adenosylmethionine binding site [chemical binding]; other site
1170562003455	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1170562003456	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1170562003457	Predicted permease [General function prediction only]; Region: COG3329
1170562003458	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1170562003459	nudix motif; other site
1170562003460	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
1170562003461	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
1170562003462	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
1170562003463	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562003464	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562003465	active site
1170562003466	phosphorylation site [posttranslational modification]
1170562003467	intermolecular recognition site; other site
1170562003468	dimerization interface [polypeptide binding]; other site
1170562003469	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1170562003470	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1170562003471	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1170562003472	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562003473	dimer interface [polypeptide binding]; other site
1170562003474	phosphorylation site [posttranslational modification]
1170562003475	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562003476	ATP binding site [chemical binding]; other site
1170562003477	Mg2+ binding site [ion binding]; other site
1170562003478	G-X-G motif; other site
1170562003479	DDE superfamily endonuclease; Region: DDE_5; cl17874
1170562003480	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1170562003481	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1170562003482	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1170562003483	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
1170562003484	oligomeric interface; other site
1170562003485	putative active site [active]
1170562003486	homodimer interface [polypeptide binding]; other site
1170562003487	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1170562003488	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1170562003489	dimer interface [polypeptide binding]; other site
1170562003490	conserved gate region; other site
1170562003491	putative PBP binding loops; other site
1170562003492	ABC-ATPase subunit interface; other site
1170562003493	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1170562003494	putative active site [active]
1170562003495	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1170562003496	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1170562003497	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1170562003498	dimer interface [polypeptide binding]; other site
1170562003499	conserved gate region; other site
1170562003500	putative PBP binding loops; other site
1170562003501	ABC-ATPase subunit interface; other site
1170562003502	amidase; Provisional; Region: PRK09201
1170562003503	Amidase; Region: Amidase; cl11426
1170562003504	Protein of unknown function (DUF4089); Region: DUF4089; pfam13318
1170562003505	Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046
1170562003506	Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244
1170562003507	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1170562003508	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1170562003509	DNA binding site [nucleotide binding]
1170562003510	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1170562003511	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1170562003512	non-specific DNA binding site [nucleotide binding]; other site
1170562003513	salt bridge; other site
1170562003514	sequence-specific DNA binding site [nucleotide binding]; other site
1170562003515	Double zinc ribbon; Region: DZR; pfam12773
1170562003516	Protein of unknown function (DUF3082); Region: DUF3082; pfam11282
1170562003517	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK02534
1170562003518	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1170562003519	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1170562003520	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
1170562003521	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1170562003522	S-adenosylmethionine binding site [chemical binding]; other site
1170562003523	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1170562003524	putative active site [active]
1170562003525	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1170562003526	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1170562003527	active site
1170562003528	ATP binding site [chemical binding]; other site
1170562003529	substrate binding site [chemical binding]; other site
1170562003530	activation loop (A-loop); other site
1170562003531	Uncharacterized conserved protein [Function unknown]; Region: COG1262
1170562003532	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
1170562003533	Protein of unknown function (DUF433); Region: DUF433; pfam04255
1170562003534	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
1170562003535	XisH protein; Region: XisH; pfam08814
1170562003536	XisI protein; Region: XisI; pfam08869
1170562003537	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1170562003538	active site
1170562003539	catalytic residues [active]
1170562003540	DNA binding site [nucleotide binding]
1170562003541	Int/Topo IB signature motif; other site
1170562003542	Predicted membrane protein [Function unknown]; Region: COG3431
1170562003543	PetN; Region: PetN; cl15376
1170562003544	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1170562003545	MarR family; Region: MarR; pfam01047
1170562003546	MarR family; Region: MarR_2; cl17246
1170562003547	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1170562003548	Cytochrome P450; Region: p450; pfam00067
1170562003549	Sporulation and spore germination; Region: Germane; pfam10646
1170562003550	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1170562003551	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1170562003552	P-loop; other site
1170562003553	Magnesium ion binding site [ion binding]; other site
1170562003554	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1170562003555	active site
1170562003556	metal binding site [ion binding]; metal-binding site
1170562003557	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1170562003558	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
1170562003559	Coenzyme A binding pocket [chemical binding]; other site
1170562003560	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
1170562003561	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1170562003562	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1170562003563	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
1170562003564	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1170562003565	PAS domain S-box; Region: sensory_box; TIGR00229
1170562003566	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562003567	putative active site [active]
1170562003568	heme pocket [chemical binding]; other site
1170562003569	GAF domain; Region: GAF; pfam01590
1170562003570	GAF domain; Region: GAF_2; pfam13185
1170562003571	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1170562003572	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562003573	dimer interface [polypeptide binding]; other site
1170562003574	phosphorylation site [posttranslational modification]
1170562003575	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562003576	ATP binding site [chemical binding]; other site
1170562003577	Mg2+ binding site [ion binding]; other site
1170562003578	G-X-G motif; other site
1170562003579	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562003580	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562003581	active site
1170562003582	phosphorylation site [posttranslational modification]
1170562003583	intermolecular recognition site; other site
1170562003584	dimerization interface [polypeptide binding]; other site
1170562003585	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
1170562003586	cytosine deaminase; Validated; Region: PRK07572
1170562003587	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
1170562003588	active site
1170562003589	light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289
1170562003590	light-dependent protochlorophyllide reductase (LPOR)-like, classical (c)-like SDRs; Region: LPOR_like_SDR_c_like; cd09810
1170562003591	putative NAD(P) binding site [chemical binding]; other site
1170562003592	active site
1170562003593	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
1170562003594	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
1170562003595	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1170562003596	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
1170562003597	Helix-turn-helix domain; Region: HTH_25; pfam13413
1170562003598	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
1170562003599	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1170562003600	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1170562003601	Helix-turn-helix domain; Region: HTH_25; pfam13413
1170562003602	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
1170562003603	Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311
1170562003604	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
1170562003605	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
1170562003606	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
1170562003607	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
1170562003608	putative active site [active]
1170562003609	Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957
1170562003610	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
1170562003611	DNA photolyase; Region: DNA_photolyase; pfam00875
1170562003612	photosystem I subunit VII; Region: psaC; CHL00065
1170562003613	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1170562003614	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
1170562003615	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
1170562003616	Uncharacterized conserved protein [Function unknown]; Region: COG1565
1170562003617	Conserved nitrate reductase-associated protein (Nitr_red_assoc); Region: Nitr_red_assoc; pfam09655
1170562003618	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1170562003619	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1170562003620	phosphopeptide binding site; other site
1170562003621	Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339
1170562003622	CHAT domain; Region: CHAT; cl17868
1170562003623	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1170562003624	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1170562003625	phosphopeptide binding site; other site
1170562003626	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
1170562003627	Protein phosphatase 2C; Region: PP2C; pfam00481
1170562003628	active site
1170562003629	Cyanobacterial and plastid NDH-1 subunit M; Region: NdhM; pfam10664
1170562003630	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1170562003631	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562003632	active site
1170562003633	phosphorylation site [posttranslational modification]
1170562003634	intermolecular recognition site; other site
1170562003635	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
1170562003636	dimerization interface [polypeptide binding]; other site
1170562003637	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1170562003638	DNA binding residues [nucleotide binding]
1170562003639	dimerization interface [polypeptide binding]; other site
1170562003640	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1170562003641	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1170562003642	active site
1170562003643	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
1170562003644	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
1170562003645	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
1170562003646	protein binding site [polypeptide binding]; other site
1170562003647	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
1170562003648	Catalytic dyad [active]
1170562003649	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1170562003650	Uncharacterized conserved protein [Function unknown]; Region: COG1434
1170562003651	putative active site [active]
1170562003652	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
1170562003653	DHH family; Region: DHH; pfam01368
1170562003654	DHHA1 domain; Region: DHHA1; pfam02272
1170562003655	TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062
1170562003656	putative dimer interface [polypeptide binding]; other site
1170562003657	putative [2Fe-2S] cluster binding site [ion binding]; other site
1170562003658	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
1170562003659	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1170562003660	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1170562003661	motif II; other site
1170562003662	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
1170562003663	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
1170562003664	active site
1170562003665	trimer interface [polypeptide binding]; other site
1170562003666	allosteric site; other site
1170562003667	active site lid [active]
1170562003668	hexamer (dimer of trimers) interface [polypeptide binding]; other site
1170562003669	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1170562003670	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1170562003671	HSP70 interaction site [polypeptide binding]; other site
1170562003672	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1170562003673	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562003674	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562003675	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562003676	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1170562003677	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1170562003678	putative acyl-acceptor binding pocket; other site
1170562003679	flavoprotein, HI0933 family; Region: TIGR00275
1170562003680	PsaD; Region: PsaD; cl03639
1170562003681	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
1170562003682	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1170562003683	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1170562003684	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562003685	binding surface
1170562003686	TPR motif; other site
1170562003687	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
1170562003688	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562003689	binding surface
1170562003690	TPR motif; other site
1170562003691	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562003692	binding surface
1170562003693	TPR motif; other site
1170562003694	CHAT domain; Region: CHAT; pfam12770
1170562003695	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
1170562003696	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
1170562003697	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
1170562003698	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
1170562003699	PDZ domain associated with archaeal and bacterial M61 glycyl-aminopeptidases. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) polypeptides and even to...; Region: PDZ_glycyl_aminopeptidase; cd00990
1170562003700	protein binding site [polypeptide binding]; other site
1170562003701	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1170562003702	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1170562003703	ligand binding site [chemical binding]; other site
1170562003704	flexible hinge region; other site
1170562003705	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
1170562003706	putative switch regulator; other site
1170562003707	non-specific DNA interactions [nucleotide binding]; other site
1170562003708	DNA binding site [nucleotide binding]
1170562003709	sequence specific DNA binding site [nucleotide binding]; other site
1170562003710	putative cAMP binding site [chemical binding]; other site
1170562003711	Protein of unknown function (DUF1499); Region: DUF1499; cl01841
1170562003712	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1170562003713	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1170562003714	active site
1170562003715	ATP binding site [chemical binding]; other site
1170562003716	substrate binding site [chemical binding]; other site
1170562003717	activation loop (A-loop); other site
1170562003718	FOG: WD40 repeat [General function prediction only]; Region: COG2319
1170562003719	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
1170562003720	structural tetrad; other site
1170562003721	AAA domain; Region: AAA_13; pfam13166
1170562003722	Protein-interacting V-domain of mammalian Alix and related domains; Region: V_Alix_like; cl14654
1170562003723	putative YPXnL-motif binding site; other site
1170562003724	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1170562003725	putative active site [active]
1170562003726	Photosystem I protein M (PsaM); Region: PsaM; pfam07465
1170562003727	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1170562003728	D-xylulose kinase; Region: XylB; TIGR01312
1170562003729	nucleotide binding site [chemical binding]; other site
1170562003730	DNA adenine methylase (dam); Region: dam; TIGR00571
1170562003731	NAD synthetase; Provisional; Region: PRK13981
1170562003732	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
1170562003733	multimer interface [polypeptide binding]; other site
1170562003734	active site
1170562003735	catalytic triad [active]
1170562003736	protein interface 1 [polypeptide binding]; other site
1170562003737	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
1170562003738	homodimer interface [polypeptide binding]; other site
1170562003739	NAD binding pocket [chemical binding]; other site
1170562003740	ATP binding pocket [chemical binding]; other site
1170562003741	Mg binding site [ion binding]; other site
1170562003742	active-site loop [active]
1170562003743	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
1170562003744	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
1170562003745	dimerization interface [polypeptide binding]; other site
1170562003746	ATP binding site [chemical binding]; other site
1170562003747	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
1170562003748	dimerization interface [polypeptide binding]; other site
1170562003749	ATP binding site [chemical binding]; other site
1170562003750	amidophosphoribosyltransferase; Provisional; Region: PRK07349
1170562003751	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
1170562003752	active site
1170562003753	tetramer interface [polypeptide binding]; other site
1170562003754	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1170562003755	active site
1170562003756	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
1170562003757	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
1170562003758	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
1170562003759	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1170562003760	molybdopterin cofactor binding site; other site
1170562003761	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
1170562003762	molybdopterin cofactor binding site; other site
1170562003763	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1170562003764	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1170562003765	hypothetical protein; Provisional; Region: PRK02509
1170562003766	Uncharacterized conserved protein [Function unknown]; Region: COG1615
1170562003767	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562003768	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562003769	binding surface
1170562003770	TPR motif; other site
1170562003771	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562003772	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562003773	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562003774	binding surface
1170562003775	TPR motif; other site
1170562003776	TPR repeat; Region: TPR_11; pfam13414
1170562003777	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562003778	binding surface
1170562003779	TPR motif; other site
1170562003780	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562003781	CHAT domain; Region: CHAT; pfam12770
1170562003782	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1170562003783	active site
1170562003784	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
1170562003785	hydrophobic ligand binding site; other site
1170562003786	Conserved TM helix; Region: TM_helix; pfam05552
1170562003787	Conserved TM helix; Region: TM_helix; pfam05552
1170562003788	Conserved TM helix; Region: TM_helix; pfam05552
1170562003789	Protein of unknown function (DUF3038); Region: DUF3038; pfam11237
1170562003790	Domain of unknown function (DUF4335); Region: DUF4335; pfam14233
1170562003791	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
1170562003792	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
1170562003793	dimerization interface [polypeptide binding]; other site
1170562003794	active site
1170562003795	metal binding site [ion binding]; metal-binding site
1170562003796	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
1170562003797	dsRNA binding site [nucleotide binding]; other site
1170562003798	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1170562003799	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1170562003800	dimer interface [polypeptide binding]; other site
1170562003801	conserved gate region; other site
1170562003802	putative PBP binding loops; other site
1170562003803	ABC-ATPase subunit interface; other site
1170562003804	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1170562003805	NMT1-like family; Region: NMT1_2; pfam13379
1170562003806	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1170562003807	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1170562003808	Walker A/P-loop; other site
1170562003809	ATP binding site [chemical binding]; other site
1170562003810	Q-loop/lid; other site
1170562003811	ABC transporter signature motif; other site
1170562003812	Walker B; other site
1170562003813	D-loop; other site
1170562003814	H-loop/switch region; other site
1170562003815	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
1170562003816	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
1170562003817	transmembrane helices; other site
1170562003818	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1170562003819	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1170562003820	ligand binding site [chemical binding]; other site
1170562003821	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
1170562003822	Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases); Region: Rab; cd00154
1170562003823	Rab subfamily motif 1 (RabSF1); other site
1170562003824	G1 box; other site
1170562003825	GTP/Mg2+ binding site [chemical binding]; other site
1170562003826	Rab subfamily motif 2 (RabSF2); other site
1170562003827	Switch I region; other site
1170562003828	G2 box; other site
1170562003829	effector interaction site; other site
1170562003830	GDI interaction site; other site
1170562003831	Rab family motif 1 (RabF1); other site
1170562003832	GEF interaction site [polypeptide binding]; other site
1170562003833	Rab family motif 2 (RabF2); other site
1170562003834	G3 box; other site
1170562003835	Switch II region; other site
1170562003836	Rab family motif 3 (RabF3); other site
1170562003837	Rab family motif 4 (RabF4); other site
1170562003838	Rab family motif 5 (RabF5); other site
1170562003839	Rab subfamily motif 3 (RabSF3); other site
1170562003840	G4 box; other site
1170562003841	G5 box; other site
1170562003842	Rab subfamily motif 4 (RabSF4); other site
1170562003843	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
1170562003844	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
1170562003845	CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206
1170562003846	CpeS-like protein; Region: CpeS; pfam09367
1170562003847	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
1170562003848	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
1170562003849	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
1170562003850	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
1170562003851	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
1170562003852	NB-ARC domain; Region: NB-ARC; pfam00931
1170562003853	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562003854	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562003855	binding surface
1170562003856	TPR motif; other site
1170562003857	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562003858	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562003859	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562003860	binding surface
1170562003861	TPR motif; other site
1170562003862	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562003863	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562003864	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562003865	binding surface
1170562003866	TPR motif; other site
1170562003867	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562003868	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562003869	binding surface
1170562003870	TPR motif; other site
1170562003871	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
1170562003872	putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606
1170562003873	Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912
1170562003874	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
1170562003875	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
1170562003876	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
1170562003877	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
1170562003878	Domain of unknown function (DUF4365); Region: DUF4365; pfam14280
1170562003879	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
1170562003880	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
1170562003881	putative active site [active]
1170562003882	Coiled-coil receptor-binding R-domain of colicin E2; Region: E2R135; pfam11570
1170562003883	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562003884	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1170562003885	binding surface
1170562003886	TPR motif; other site
1170562003887	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562003888	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562003889	binding surface
1170562003890	TPR motif; other site
1170562003891	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562003892	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562003893	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562003894	binding surface
1170562003895	TPR motif; other site
1170562003896	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562003897	CHAT domain; Region: CHAT; pfam12770
1170562003898	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1170562003899	Domain of unknown function (DUF3598); Region: DUF3598; pfam12204
1170562003900	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1170562003901	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
1170562003902	iron-sulfur cluster [ion binding]; other site
1170562003903	[2Fe-2S] cluster binding site [ion binding]; other site
1170562003904	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1170562003905	hydrophobic ligand binding site; other site
1170562003906	Integrase core domain; Region: rve; pfam00665
1170562003907	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
1170562003908	AAA domain; Region: AAA_22; pfam13401
1170562003909	TniQ; Region: TniQ; pfam06527
1170562003910	WD domain, G-beta repeat; Region: WD40; pfam00400
1170562003911	WD40 repeats; Region: WD40; smart00320
1170562003912	FOG: WD40 repeat [General function prediction only]; Region: COG2319
1170562003913	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
1170562003914	structural tetrad; other site
1170562003915	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
1170562003916	structural tetrad; other site
1170562003917	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
1170562003918	Transposase [DNA replication, recombination, and repair]; Region: COG5421
1170562003919	CHAT domain; Region: CHAT; cl17868
1170562003920	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
1170562003921	HsdM N-terminal domain; Region: HsdM_N; pfam12161
1170562003922	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1170562003923	Restriction endonuclease; Region: Mrr_cat; pfam04471
1170562003924	NACHT domain; Region: NACHT; pfam05729
1170562003925	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562003926	FOG: WD40 repeat [General function prediction only]; Region: COG2319
1170562003927	WD40 repeats; Region: WD40; smart00320
1170562003928	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
1170562003929	structural tetrad; other site
1170562003930	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
1170562003931	structural tetrad; other site
1170562003932	FOG: WD40 repeat [General function prediction only]; Region: COG2319
1170562003933	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
1170562003934	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1170562003935	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
1170562003936	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1170562003937	ATP binding site [chemical binding]; other site
1170562003938	putative Mg++ binding site [ion binding]; other site
1170562003939	Protein of unknown function DUF262; Region: DUF262; pfam03235
1170562003940	Uncharacterized conserved protein [Function unknown]; Region: COG1479
1170562003941	Uncharacterized conserved protein [Function unknown]; Region: COG3472
1170562003942	hypothetical protein; Region: PHA01623
1170562003943	Alkaline and neutral invertase; Region: Glyco_hydro_100; pfam12899
1170562003944	Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980
1170562003945	16S rRNA methyltransferase B; Provisional; Region: PRK14901
1170562003946	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
1170562003947	putative RNA binding site [nucleotide binding]; other site
1170562003948	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1170562003949	S-adenosylmethionine binding site [chemical binding]; other site
1170562003950	tellurium resistance terB-like protein; Region: terB_like; cd07177
1170562003951	metal binding site [ion binding]; metal-binding site
1170562003952	HEAT-like repeat; Region: HEAT_EZ; pfam13513
1170562003953	2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209
1170562003954	2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549
1170562003955	dimer interface [polypeptide binding]; other site
1170562003956	active site
1170562003957	catalytic residue [active]
1170562003958	metal binding site [ion binding]; metal-binding site
1170562003959	GDYXXLXY protein; Region: GDYXXLXY; pfam14345
1170562003960	Predicted membrane protein (DUF2157); Region: DUF2157; cl10480
1170562003961	S-layer homology domain; Region: SLH; pfam00395
1170562003962	S-layer homology domain; Region: SLH; pfam00395
1170562003963	S-layer homology domain; Region: SLH; pfam00395
1170562003964	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
1170562003965	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
1170562003966	TPP-binding site; other site
1170562003967	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1170562003968	PYR/PP interface [polypeptide binding]; other site
1170562003969	dimer interface [polypeptide binding]; other site
1170562003970	TPP binding site [chemical binding]; other site
1170562003971	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1170562003972	Calx-beta domain; Region: Calx-beta; cl02522
1170562003973	Calx-beta domain; Region: Calx-beta; cl02522
1170562003974	Family description; Region: VCBS; pfam13517
1170562003975	Family description; Region: VCBS; pfam13517
1170562003976	Family description; Region: VCBS; pfam13517
1170562003977	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1170562003978	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1170562003979	Walker A/P-loop; other site
1170562003980	ATP binding site [chemical binding]; other site
1170562003981	Q-loop/lid; other site
1170562003982	ABC transporter signature motif; other site
1170562003983	Walker B; other site
1170562003984	D-loop; other site
1170562003985	H-loop/switch region; other site
1170562003986	hypothetical protein; Provisional; Region: PRK13683
1170562003987	D2 subunit  of photosystem II (PS II); Region: Photosystem-II_D2; cd09288
1170562003988	D1 interface; other site
1170562003989	chlorophyll binding site; other site
1170562003990	pheophytin binding site; other site
1170562003991	beta carotene binding site; other site
1170562003992	cytochrome b559 beta interface; other site
1170562003993	quinone binding site; other site
1170562003994	cytochrome b559 alpha interface; other site
1170562003995	protein J interface; other site
1170562003996	protein H interface; other site
1170562003997	protein X interface; other site
1170562003998	core light harvesting protein interface; other site
1170562003999	protein L interface; other site
1170562004000	CP43 interface; other site
1170562004001	protein T interface; other site
1170562004002	Fe binding site [ion binding]; other site
1170562004003	protein M interface; other site
1170562004004	Mn-stabilizing polypeptide interface; other site
1170562004005	bromide binding site; other site
1170562004006	cytochrome c-550 interface; other site
1170562004007	Uncharacterized protein conserved in bacteria (DUF2195); Region: DUF2195; cl02042
1170562004008	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1170562004009	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1170562004010	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
1170562004011	Chain length determinant protein; Region: Wzz; pfam02706
1170562004012	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
1170562004013	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1170562004014	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
1170562004015	O-Antigen ligase; Region: Wzy_C; pfam04932
1170562004016	Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111
1170562004017	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1170562004018	active site
1170562004019	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898
1170562004020	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
1170562004021	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
1170562004022	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1170562004023	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
1170562004024	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
1170562004025	catalytic triad [active]
1170562004026	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1170562004027	CHAT domain; Region: CHAT; pfam12770
1170562004028	Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484
1170562004029	active site
1170562004030	catalytic triad [active]
1170562004031	Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
1170562004032	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
1170562004033	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1170562004034	Circadian oscillating protein COP23; Region: COP23; pfam14218
1170562004035	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
1170562004036	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
1170562004037	Walker A/P-loop; other site
1170562004038	ATP binding site [chemical binding]; other site
1170562004039	Q-loop/lid; other site
1170562004040	Rad50 zinc hook motif; Region: Rad50_zn_hook; pfam04423
1170562004041	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1170562004042	ABC transporter signature motif; other site
1170562004043	Walker B; other site
1170562004044	D-loop; other site
1170562004045	H-loop/switch region; other site
1170562004046	Domain of unknown function (DUF4308); Region: DUF4308; pfam14159
1170562004047	S-layer homology domain; Region: SLH; pfam00395
1170562004048	S-layer homology domain; Region: SLH; pfam00395
1170562004049	S-layer homology domain; Region: SLH; pfam00395
1170562004050	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
1170562004051	SmpB-tmRNA interface; other site
1170562004052	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
1170562004053	NMT1/THI5 like; Region: NMT1; pfam09084
1170562004054	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562004055	binding surface
1170562004056	TPR motif; other site
1170562004057	TPR repeat; Region: TPR_11; pfam13414
1170562004058	glutaminase A; Region: Gln_ase; TIGR03814
1170562004059	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
1170562004060	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
1170562004061	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
1170562004062	bifunctional pantoate ligase/cytidylate kinase; Provisional; Region: PRK13477
1170562004063	Pantoate-beta-alanine ligase; Region: PanC; cd00560
1170562004064	active site
1170562004065	ATP-binding site [chemical binding]; other site
1170562004066	pantoate-binding site; other site
1170562004067	HXXH motif; other site
1170562004068	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
1170562004069	CMP-binding site; other site
1170562004070	The sites determining sugar specificity; other site
1170562004071	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1170562004072	putative active site [active]
1170562004073	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
1170562004074	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1170562004075	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
1170562004076	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1170562004077	active site
1170562004078	NTP binding site [chemical binding]; other site
1170562004079	metal binding triad [ion binding]; metal-binding site
1170562004080	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1170562004081	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
1170562004082	Hypothetical chloroplast protein Ycf34; Region: Ycf34; pfam10718
1170562004083	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
1170562004084	Aluminium resistance protein; Region: Alum_res; pfam06838
1170562004085	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
1170562004086	Fatty acid desaturase; Region: FA_desaturase; pfam00487
1170562004087	Di-iron ligands [ion binding]; other site
1170562004088	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
1170562004089	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
1170562004090	putative di-iron ligands [ion binding]; other site
1170562004091	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
1170562004092	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
1170562004093	putative di-iron ligands [ion binding]; other site
1170562004094	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
1170562004095	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
1170562004096	putative di-iron ligands [ion binding]; other site
1170562004097	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
1170562004098	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
1170562004099	putative catalytic cysteine [active]
1170562004100	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
1170562004101	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1170562004102	ATP binding site [chemical binding]; other site
1170562004103	putative Mg++ binding site [ion binding]; other site
1170562004104	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1170562004105	nucleotide binding region [chemical binding]; other site
1170562004106	ATP-binding site [chemical binding]; other site
1170562004107	Endonuclease, Uma2 family (restriction endonuclease fold) [General function prediction only]; Region: Uma2; COG4636
1170562004108	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
1170562004109	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
1170562004110	Moco binding site; other site
1170562004111	metal coordination site [ion binding]; other site
1170562004112	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033
1170562004113	Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117
1170562004114	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
1170562004115	DNA-binding interface [nucleotide binding]; DNA binding site
1170562004116	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
1170562004117	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
1170562004118	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
1170562004119	putative active site [active]
1170562004120	putative substrate binding site [chemical binding]; other site
1170562004121	putative cosubstrate binding site; other site
1170562004122	catalytic site [active]
1170562004123	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
1170562004124	Conserved hypothetical protein (Lin0512_fam); Region: Lin0512_fam; cl09807
1170562004125	Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201
1170562004126	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1170562004127	putative Mg++ binding site [ion binding]; other site
1170562004128	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1170562004129	nucleotide binding region [chemical binding]; other site
1170562004130	ATP-binding site [chemical binding]; other site
1170562004131	Domain of unknown function (DUF4291); Region: DUF4291; pfam14124
1170562004132	CHASE3 domain; Region: CHASE3; pfam05227
1170562004133	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1170562004134	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562004135	putative active site [active]
1170562004136	heme pocket [chemical binding]; other site
1170562004137	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1170562004138	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562004139	putative active site [active]
1170562004140	heme pocket [chemical binding]; other site
1170562004141	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562004142	ATP binding site [chemical binding]; other site
1170562004143	Mg2+ binding site [ion binding]; other site
1170562004144	G-X-G motif; other site
1170562004145	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562004146	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562004147	active site
1170562004148	phosphorylation site [posttranslational modification]
1170562004149	intermolecular recognition site; other site
1170562004150	dimerization interface [polypeptide binding]; other site
1170562004151	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
1170562004152	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
1170562004153	GDP-binding site [chemical binding]; other site
1170562004154	ACT binding site; other site
1170562004155	IMP binding site; other site
1170562004156	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
1170562004157	5S rRNA interface [nucleotide binding]; other site
1170562004158	CTC domain interface [polypeptide binding]; other site
1170562004159	L16 interface [polypeptide binding]; other site
1170562004160	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
1170562004161	Predicted kinase [General function prediction only]; Region: COG0645
1170562004162	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
1170562004163	ATP-binding site [chemical binding]; other site
1170562004164	Gluconate-6-phosphate binding site [chemical binding]; other site
1170562004165	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
1170562004166	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1170562004167	putative active site [active]
1170562004168	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
1170562004169	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1170562004170	Coenzyme A binding pocket [chemical binding]; other site
1170562004171	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
1170562004172	Protein of unknown function (DUF1292); Region: DUF1292; pfam06949
1170562004173	Protein of unknown function (DUF3727); Region: DUF3727; pfam12527
1170562004174	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
1170562004175	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1170562004176	active site
1170562004177	motif I; other site
1170562004178	motif II; other site
1170562004179	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
1170562004180	NAD(P) binding pocket [chemical binding]; other site
1170562004181	Protein of unknown function (DUF2997); Region: DUF2997; pfam11211
1170562004182	Ycf35; Provisional; Region: ycf35; CHL00193
1170562004183	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
1170562004184	yiaA/B two helix domain; Region: YiaAB; cl01759
1170562004185	Calx-beta domain; Region: Calx-beta; cl02522
1170562004186	Calx-beta domain; Region: Calx-beta; pfam03160
1170562004187	Family description; Region: VCBS; pfam13517
1170562004188	Family description; Region: VCBS; pfam13517
1170562004189	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1170562004190	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
1170562004191	NAD(P) binding site [chemical binding]; other site
1170562004192	homotetramer interface [polypeptide binding]; other site
1170562004193	homodimer interface [polypeptide binding]; other site
1170562004194	active site
1170562004195	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1170562004196	catalytic residues [active]
1170562004197	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
1170562004198	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1170562004199	S-adenosylmethionine binding site [chemical binding]; other site
1170562004200	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
1170562004201	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
1170562004202	purine monophosphate binding site [chemical binding]; other site
1170562004203	dimer interface [polypeptide binding]; other site
1170562004204	putative catalytic residues [active]
1170562004205	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
1170562004206	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
1170562004207	Predicted integral membrane protein [Function unknown]; Region: COG5542
1170562004208	DDE superfamily endonuclease; Region: DDE_5; cl17874
1170562004209	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1170562004210	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
1170562004211	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
1170562004212	Ligand binding site; other site
1170562004213	Putative Catalytic site; other site
1170562004214	DXD motif; other site
1170562004215	Uncharacterized protein family UPF0546; Region: UPF0546; pfam10639
1170562004216	Predicted integral membrane protein [Function unknown]; Region: COG5542
1170562004217	delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884
1170562004218	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
1170562004219	NodB motif; other site
1170562004220	active site
1170562004221	catalytic site [active]
1170562004222	metal binding site [ion binding]; metal-binding site
1170562004223	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1170562004224	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
1170562004225	NodB motif; other site
1170562004226	active site
1170562004227	catalytic site [active]
1170562004228	metal binding site [ion binding]; metal-binding site
1170562004229	Caspase domain; Region: Peptidase_C14; pfam00656
1170562004230	Uncharacterized conserved protein [Function unknown]; Region: COG1262
1170562004231	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
1170562004232	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
1170562004233	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
1170562004234	active site
1170562004235	dimer interface [polypeptide binding]; other site
1170562004236	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
1170562004237	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
1170562004238	active site
1170562004239	FMN binding site [chemical binding]; other site
1170562004240	substrate binding site [chemical binding]; other site
1170562004241	3Fe-4S cluster binding site [ion binding]; other site
1170562004242	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
1170562004243	domain interface; other site
1170562004244	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
1170562004245	Cupin domain; Region: Cupin_2; cl17218
1170562004246	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
1170562004247	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
1170562004248	S17 interaction site [polypeptide binding]; other site
1170562004249	S8 interaction site; other site
1170562004250	16S rRNA interaction site [nucleotide binding]; other site
1170562004251	streptomycin interaction site [chemical binding]; other site
1170562004252	23S rRNA interaction site [nucleotide binding]; other site
1170562004253	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
1170562004254	30S ribosomal protein S7; Validated; Region: PRK05302
1170562004255	elongation factor G; Reviewed; Region: PRK00007
1170562004256	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
1170562004257	G1 box; other site
1170562004258	putative GEF interaction site [polypeptide binding]; other site
1170562004259	GTP/Mg2+ binding site [chemical binding]; other site
1170562004260	Switch I region; other site
1170562004261	G2 box; other site
1170562004262	G3 box; other site
1170562004263	Switch II region; other site
1170562004264	G4 box; other site
1170562004265	G5 box; other site
1170562004266	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1170562004267	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1170562004268	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1170562004269	elongation factor Tu; Region: tufA; CHL00071
1170562004270	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1170562004271	G1 box; other site
1170562004272	GEF interaction site [polypeptide binding]; other site
1170562004273	GTP/Mg2+ binding site [chemical binding]; other site
1170562004274	Switch I region; other site
1170562004275	G2 box; other site
1170562004276	G3 box; other site
1170562004277	Switch II region; other site
1170562004278	G4 box; other site
1170562004279	G5 box; other site
1170562004280	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
1170562004281	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1170562004282	Antibiotic Binding Site [chemical binding]; other site
1170562004283	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
1170562004284	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
1170562004285	prephenate dehydratase; Provisional; Region: PRK11898
1170562004286	Prephenate dehydratase; Region: PDT; pfam00800
1170562004287	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
1170562004288	putative L-Phe binding site [chemical binding]; other site
1170562004289	Protein of unknown function (DUF1997); Region: DUF1997; pfam09366
1170562004290	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
1170562004291	RNA/DNA hybrid binding site [nucleotide binding]; other site
1170562004292	active site
1170562004293	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
1170562004294	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
1170562004295	dimer interface [polypeptide binding]; other site
1170562004296	putative anticodon binding site; other site
1170562004297	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
1170562004298	motif 1; other site
1170562004299	active site
1170562004300	motif 2; other site
1170562004301	motif 3; other site
1170562004302	FOG: WD40 repeat [General function prediction only]; Region: COG2319
1170562004303	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
1170562004304	structural tetrad; other site
1170562004305	Protein of unknown function (DUF3571); Region: DUF3571; pfam12095
1170562004306	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562004307	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562004308	active site
1170562004309	phosphorylation site [posttranslational modification]
1170562004310	intermolecular recognition site; other site
1170562004311	dimerization interface [polypeptide binding]; other site
1170562004312	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1170562004313	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1170562004314	metal binding site [ion binding]; metal-binding site
1170562004315	active site
1170562004316	I-site; other site
1170562004317	Protein of unknown function (DUF3493); Region: DUF3493; pfam11998
1170562004318	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1170562004319	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1170562004320	NAD(P) binding site [chemical binding]; other site
1170562004321	active site
1170562004322	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1170562004323	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1170562004324	putative acyl-acceptor binding pocket; other site
1170562004325	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
1170562004326	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1170562004327	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1170562004328	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
1170562004329	catalytic motif [active]
1170562004330	Catalytic residue [active]
1170562004331	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
1170562004332	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
1170562004333	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
1170562004334	catalytic site [active]
1170562004335	subunit interface [polypeptide binding]; other site
1170562004336	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
1170562004337	active site
1170562004338	metal binding site [ion binding]; metal-binding site
1170562004339	dimerization interface [polypeptide binding]; other site
1170562004340	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
1170562004341	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
1170562004342	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1170562004343	Domain of unknown function (DUF1816); Region: DUF1816; pfam08846
1170562004344	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1170562004345	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1170562004346	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1170562004347	catalytic residue [active]
1170562004348	YacP-like NYN domain; Region: NYN_YacP; cl01491
1170562004349	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1170562004350	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562004351	active site
1170562004352	phosphorylation site [posttranslational modification]
1170562004353	intermolecular recognition site; other site
1170562004354	dimerization interface [polypeptide binding]; other site
1170562004355	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1170562004356	DNA binding site [nucleotide binding]
1170562004357	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
1170562004358	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
1170562004359	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
1170562004360	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
1170562004361	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
1170562004362	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1170562004363	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1170562004364	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562004365	PAS domain; Region: PAS_9; pfam13426
1170562004366	putative active site [active]
1170562004367	heme pocket [chemical binding]; other site
1170562004368	PAS domain; Region: PAS; smart00091
1170562004369	PAS domain; Region: PAS_9; pfam13426
1170562004370	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562004371	putative active site [active]
1170562004372	heme pocket [chemical binding]; other site
1170562004373	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1170562004374	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562004375	putative active site [active]
1170562004376	heme pocket [chemical binding]; other site
1170562004377	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562004378	dimer interface [polypeptide binding]; other site
1170562004379	phosphorylation site [posttranslational modification]
1170562004380	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562004381	ATP binding site [chemical binding]; other site
1170562004382	G-X-G motif; other site
1170562004383	von Willebrand factor; Region: vWF_A; pfam12450
1170562004384	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
1170562004385	VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465
1170562004386	metal ion-dependent adhesion site (MIDAS); other site
1170562004387	Domain of unknown function (DUF3520); Region: DUF3520; pfam12034
1170562004388	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1170562004389	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1170562004390	active site
1170562004391	ATP binding site [chemical binding]; other site
1170562004392	substrate binding site [chemical binding]; other site
1170562004393	activation loop (A-loop); other site
1170562004394	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562004395	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
1170562004396	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562004397	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1170562004398	GTP-binding protein Der; Reviewed; Region: PRK00093
1170562004399	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
1170562004400	G1 box; other site
1170562004401	GTP/Mg2+ binding site [chemical binding]; other site
1170562004402	Switch I region; other site
1170562004403	G2 box; other site
1170562004404	Switch II region; other site
1170562004405	G3 box; other site
1170562004406	G4 box; other site
1170562004407	G5 box; other site
1170562004408	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
1170562004409	G1 box; other site
1170562004410	GTP/Mg2+ binding site [chemical binding]; other site
1170562004411	Switch I region; other site
1170562004412	G2 box; other site
1170562004413	G3 box; other site
1170562004414	Switch II region; other site
1170562004415	G4 box; other site
1170562004416	G5 box; other site
1170562004417	phosphodiesterase YaeI; Provisional; Region: PRK11340
1170562004418	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
1170562004419	putative active site [active]
1170562004420	putative metal binding site [ion binding]; other site
1170562004421	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1170562004422	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1170562004423	ligand binding site [chemical binding]; other site
1170562004424	flexible hinge region; other site
1170562004425	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
1170562004426	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1170562004427	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
1170562004428	4Fe-4S binding domain; Region: Fer4_5; pfam12801
1170562004429	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
1170562004430	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1170562004431	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1170562004432	Magnesium ion binding site [ion binding]; other site
1170562004433	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
1170562004434	Alanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: AlaS; COG0013
1170562004435	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
1170562004436	23S rRNA binding site [nucleotide binding]; other site
1170562004437	L21 binding site [polypeptide binding]; other site
1170562004438	L13 binding site [polypeptide binding]; other site
1170562004439	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
1170562004440	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
1170562004441	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1170562004442	Coenzyme A binding pocket [chemical binding]; other site
1170562004443	Cell cycle protein; Region: FTSW_RODA_SPOVE; pfam01098
1170562004444	putative glutathione S-transferase; Provisional; Region: PRK10357
1170562004445	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1170562004446	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
1170562004447	N-terminal domain interface [polypeptide binding]; other site
1170562004448	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
1170562004449	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
1170562004450	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1170562004451	multiple promoter invertase; Provisional; Region: mpi; PRK13413
1170562004452	catalytic residues [active]
1170562004453	catalytic nucleophile [active]
1170562004454	Presynaptic Site I dimer interface [polypeptide binding]; other site
1170562004455	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1170562004456	Synaptic Flat tetramer interface [polypeptide binding]; other site
1170562004457	Synaptic Site I dimer interface [polypeptide binding]; other site
1170562004458	DNA binding site [nucleotide binding]
1170562004459	Homeodomain-like domain; Region: HTH_23; pfam13384
1170562004460	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
1170562004461	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562004462	putative active site [active]
1170562004463	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
1170562004464	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562004465	dimer interface [polypeptide binding]; other site
1170562004466	phosphorylation site [posttranslational modification]
1170562004467	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562004468	ATP binding site [chemical binding]; other site
1170562004469	Mg2+ binding site [ion binding]; other site
1170562004470	G-X-G motif; other site
1170562004471	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
1170562004472	Phycobilisome protein; Region: Phycobilisome; cl08227
1170562004473	Phycobilisome protein; Region: Phycobilisome; cl08227
1170562004474	phycobillisome linker protein; Region: apcE; CHL00091
1170562004475	Phycobilisome protein; Region: Phycobilisome; cl08227
1170562004476	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
1170562004477	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
1170562004478	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
1170562004479	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
1170562004480	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562004481	binding surface
1170562004482	TPR motif; other site
1170562004483	TPR repeat; Region: TPR_11; pfam13414
1170562004484	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1170562004485	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1170562004486	S-adenosylmethionine binding site [chemical binding]; other site
1170562004487	ATP synthase I chain; Region: ATP_synt_I; pfam03899
1170562004488	ATP synthase CF0 A subunit; Region: atpI; CHL00046
1170562004489	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
1170562004490	F0F1 ATP synthase subunit C; Validated; Region: PRK07354
1170562004491	F0F1 ATP synthase subunit B'; Validated; Region: PRK07353
1170562004492	ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430
1170562004493	F0F1 ATP synthase subunit B; Validated; Region: PRK07352
1170562004494	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
1170562004495	F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210
1170562004496	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
1170562004497	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
1170562004498	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1170562004499	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
1170562004500	beta subunit interaction interface [polypeptide binding]; other site
1170562004501	Walker A motif; other site
1170562004502	ATP binding site [chemical binding]; other site
1170562004503	Walker B motif; other site
1170562004504	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1170562004505	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
1170562004506	core domain interface [polypeptide binding]; other site
1170562004507	delta subunit interface [polypeptide binding]; other site
1170562004508	epsilon subunit interface [polypeptide binding]; other site
1170562004509	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1170562004510	dimer interface [polypeptide binding]; other site
1170562004511	substrate binding site [chemical binding]; other site
1170562004512	ATP binding site [chemical binding]; other site
1170562004513	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
1170562004514	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
1170562004515	Nitrogen regulatory protein P-II; Region: P-II; smart00938
1170562004516	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
1170562004517	active site
1170562004518	dimerization interface [polypeptide binding]; other site
1170562004519	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1170562004520	putative active site [active]
1170562004521	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
1170562004522	This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800
1170562004523	active site
1170562004524	substrate binding site [chemical binding]; other site
1170562004525	metal binding site [ion binding]; metal-binding site
1170562004526	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1170562004527	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087
1170562004528	PIN domain; Region: PIN; pfam01850
1170562004529	Domain of unknown function (DUF4325); Region: DUF4325; pfam14213
1170562004530	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
1170562004531	dimer interface [polypeptide binding]; other site
1170562004532	motif 1; other site
1170562004533	active site
1170562004534	motif 2; other site
1170562004535	motif 3; other site
1170562004536	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
1170562004537	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1170562004538	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1170562004539	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
1170562004540	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
1170562004541	dimerization interface [polypeptide binding]; other site
1170562004542	putative ATP binding site [chemical binding]; other site
1170562004543	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
1170562004544	PHP domain; Region: PHP; pfam02811
1170562004545	active site
1170562004546	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562004547	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562004548	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
1170562004549	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
1170562004550	B12 binding site [chemical binding]; other site
1170562004551	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
1170562004552	CHAT domain; Region: CHAT; pfam12770
1170562004553	AAA ATPase domain; Region: AAA_16; pfam13191
1170562004554	Walker A motif; other site
1170562004555	ATP binding site [chemical binding]; other site
1170562004556	Walker B motif; other site
1170562004557	TPR repeat; Region: TPR_11; pfam13414
1170562004558	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562004559	binding surface
1170562004560	TPR motif; other site
1170562004561	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562004562	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562004563	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562004564	binding surface
1170562004565	TPR motif; other site
1170562004566	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562004567	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562004568	binding surface
1170562004569	TPR motif; other site
1170562004570	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562004571	Bacterial Ig-like domain; Region: Big_5; pfam13205
1170562004572	TIGR03943 family protein; Region: TIGR03943
1170562004573	Predicted permeases [General function prediction only]; Region: COG0701
1170562004574	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1170562004575	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1170562004576	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562004577	ATP binding site [chemical binding]; other site
1170562004578	Mg2+ binding site [ion binding]; other site
1170562004579	G-X-G motif; other site
1170562004580	Domain of unknown function (DUF2382); Region: DUF2382; pfam09557
1170562004581	PRC-barrel domain; Region: PRC; pfam05239
1170562004582	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3861
1170562004583	Cupin domain; Region: Cupin_2; cl17218
1170562004584	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1170562004585	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
1170562004586	intersubunit interface [polypeptide binding]; other site
1170562004587	thymidylate kinase; Validated; Region: tmk; PRK00698
1170562004588	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
1170562004589	TMP-binding site; other site
1170562004590	ATP-binding site [chemical binding]; other site
1170562004591	DNA polymerase III subunit delta'; Validated; Region: PRK07399
1170562004592	DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271
1170562004593	HSP70 interaction site [polypeptide binding]; other site
1170562004594	DDE superfamily endonuclease; Region: DDE_5; cl17874
1170562004595	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1170562004596	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
1170562004597	ABC1 family; Region: ABC1; cl17513
1170562004598	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1170562004599	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562004600	active site
1170562004601	phosphorylation site [posttranslational modification]
1170562004602	intermolecular recognition site; other site
1170562004603	dimerization interface [polypeptide binding]; other site
1170562004604	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1170562004605	DNA binding site [nucleotide binding]
1170562004606	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1170562004607	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562004608	dimer interface [polypeptide binding]; other site
1170562004609	phosphorylation site [posttranslational modification]
1170562004610	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562004611	ATP binding site [chemical binding]; other site
1170562004612	Mg2+ binding site [ion binding]; other site
1170562004613	G-X-G motif; other site
1170562004614	Phosphate uptake regulator [Inorganic ion transport and metabolism]; Region: PhoU; COG0704
1170562004615	PhoU domain; Region: PhoU; pfam01895
1170562004616	PhoU domain; Region: PhoU; pfam01895
1170562004617	global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
1170562004618	S-layer homology domain; Region: SLH; pfam00395
1170562004619	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
1170562004620	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562004621	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562004622	active site
1170562004623	phosphorylation site [posttranslational modification]
1170562004624	intermolecular recognition site; other site
1170562004625	dimerization interface [polypeptide binding]; other site
1170562004626	PAS domain S-box; Region: sensory_box; TIGR00229
1170562004627	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562004628	putative active site [active]
1170562004629	heme pocket [chemical binding]; other site
1170562004630	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1170562004631	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562004632	dimer interface [polypeptide binding]; other site
1170562004633	phosphorylation site [posttranslational modification]
1170562004634	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1170562004635	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562004636	ATP binding site [chemical binding]; other site
1170562004637	Mg2+ binding site [ion binding]; other site
1170562004638	G-X-G motif; other site
1170562004639	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
1170562004640	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
1170562004641	Nucleoside recognition; Region: Gate; pfam07670
1170562004642	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1170562004643	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
1170562004644	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
1170562004645	Protein of unknown function (DUF565); Region: DUF565; pfam04483
1170562004646	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
1170562004647	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
1170562004648	iron-sulfur cluster [ion binding]; other site
1170562004649	[2Fe-2S] cluster binding site [ion binding]; other site
1170562004650	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
1170562004651	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1170562004652	HlyD family secretion protein; Region: HlyD_3; pfam13437
1170562004653	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1170562004654	metal binding site [ion binding]; metal-binding site
1170562004655	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
1170562004656	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1170562004657	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1170562004658	Probable transposase; Region: OrfB_IS605; pfam01385
1170562004659	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
1170562004660	agmatinase; Region: agmatinase; TIGR01230
1170562004661	Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593
1170562004662	putative active site [active]
1170562004663	Mn binding site [ion binding]; other site
1170562004664	A bacterial subgroup of the C-type lectin-like (CTLD) domain; a subgroup of bacterial protein domains homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins; Region: CLECT_VCBS; cd03603
1170562004665	ligand binding surface [chemical binding]; other site
1170562004666	Family description; Region: VCBS; pfam13517
1170562004667	Family description; Region: VCBS; pfam13517
1170562004668	Family description; Region: VCBS; pfam13517
1170562004669	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
1170562004670	Domain of unknown function (DUF4335); Region: DUF4335; pfam14233
1170562004671	Protein of unknown function (DUF3038); Region: DUF3038; pfam11237
1170562004672	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1170562004673	active site
1170562004674	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1170562004675	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1170562004676	dimer interface [polypeptide binding]; other site
1170562004677	conserved gate region; other site
1170562004678	putative PBP binding loops; other site
1170562004679	ABC-ATPase subunit interface; other site
1170562004680	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1170562004681	Mn2+-dependent serine/threonine protein kinase [Signal transduction mechanisms]; Region: COG3642
1170562004682	active site
1170562004683	ATP binding site [chemical binding]; other site
1170562004684	substrate binding site [chemical binding]; other site
1170562004685	activation loop (A-loop); other site
1170562004686	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
1170562004687	Transferrin; Region: Transferrin; cl02460
1170562004688	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
1170562004689	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
1170562004690	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
1170562004691	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1170562004692	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1170562004693	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
1170562004694	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
1170562004695	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
1170562004696	Flavodoxin; Region: Flavodoxin_1; pfam00258
1170562004697	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
1170562004698	pantothenate kinase; Reviewed; Region: PRK13331
1170562004699	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1170562004700	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
1170562004701	catalytic site [active]
1170562004702	Uncharacterized conserved protein [Function unknown]; Region: COG5464
1170562004703	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
1170562004704	nudix motif; other site
1170562004705	argininosuccinate lyase; Provisional; Region: PRK00855
1170562004706	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
1170562004707	active sites [active]
1170562004708	tetramer interface [polypeptide binding]; other site
1170562004709	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562004710	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1170562004711	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562004712	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562004713	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
1170562004714	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562004715	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1170562004716	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562004717	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1170562004718	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
1170562004719	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
1170562004720	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992
1170562004721	active site
1170562004722	Zn binding site [ion binding]; other site
1170562004723	DNA gyrase subunit A; Validated; Region: PRK05560
1170562004724	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1170562004725	CAP-like domain; other site
1170562004726	active site
1170562004727	primary dimer interface [polypeptide binding]; other site
1170562004728	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1170562004729	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1170562004730	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1170562004731	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1170562004732	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1170562004733	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1170562004734	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
1170562004735	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
1170562004736	putative active site [active]
1170562004737	catalytic triad [active]
1170562004738	putative dimer interface [polypeptide binding]; other site
1170562004739	Ferritin-like domain; Region: Ferritin; pfam00210
1170562004740	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
1170562004741	dinuclear metal binding motif [ion binding]; other site
1170562004742	Heme NO binding; Region: HNOB; pfam07700
1170562004743	Heme NO binding associated; Region: HNOBA; pfam07701
1170562004744	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562004745	PAS fold; Region: PAS_3; pfam08447
1170562004746	putative active site [active]
1170562004747	heme pocket [chemical binding]; other site
1170562004748	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562004749	dimer interface [polypeptide binding]; other site
1170562004750	phosphorylation site [posttranslational modification]
1170562004751	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562004752	ATP binding site [chemical binding]; other site
1170562004753	Mg2+ binding site [ion binding]; other site
1170562004754	G-X-G motif; other site
1170562004755	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
1170562004756	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562004757	active site
1170562004758	phosphorylation site [posttranslational modification]
1170562004759	intermolecular recognition site; other site
1170562004760	dimerization interface [polypeptide binding]; other site
1170562004761	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562004762	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562004763	active site
1170562004764	phosphorylation site [posttranslational modification]
1170562004765	intermolecular recognition site; other site
1170562004766	dimerization interface [polypeptide binding]; other site
1170562004767	Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264
1170562004768	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1170562004769	S-adenosylmethionine binding site [chemical binding]; other site
1170562004770	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
1170562004771	homodimer interface [polypeptide binding]; other site
1170562004772	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1170562004773	catalytic residue [active]
1170562004774	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
1170562004775	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1170562004776	metal binding site 2 [ion binding]; metal-binding site
1170562004777	putative DNA binding helix; other site
1170562004778	metal binding site 1 [ion binding]; metal-binding site
1170562004779	dimer interface [polypeptide binding]; other site
1170562004780	structural Zn2+ binding site [ion binding]; other site
1170562004781	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
1170562004782	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
1170562004783	Walker A/P-loop; other site
1170562004784	ATP binding site [chemical binding]; other site
1170562004785	Q-loop/lid; other site
1170562004786	ABC transporter signature motif; other site
1170562004787	Walker B; other site
1170562004788	D-loop; other site
1170562004789	H-loop/switch region; other site
1170562004790	TOBE domain; Region: TOBE; pfam03459
1170562004791	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1170562004792	dimer interface [polypeptide binding]; other site
1170562004793	conserved gate region; other site
1170562004794	putative PBP binding loops; other site
1170562004795	ABC-ATPase subunit interface; other site
1170562004796	sulfate transport protein; Provisional; Region: cysT; CHL00187
1170562004797	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1170562004798	dimer interface [polypeptide binding]; other site
1170562004799	conserved gate region; other site
1170562004800	putative PBP binding loops; other site
1170562004801	ABC-ATPase subunit interface; other site
1170562004802	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
1170562004803	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
1170562004804	Mg++ binding site [ion binding]; other site
1170562004805	putative catalytic motif [active]
1170562004806	substrate binding site [chemical binding]; other site
1170562004807	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1170562004808	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1170562004809	ring oligomerisation interface [polypeptide binding]; other site
1170562004810	ATP/Mg binding site [chemical binding]; other site
1170562004811	stacking interactions; other site
1170562004812	hinge regions; other site
1170562004813	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
1170562004814	Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828
1170562004815	oligomer interface [polypeptide binding]; other site
1170562004816	metal binding site [ion binding]; metal-binding site
1170562004817	metal binding site [ion binding]; metal-binding site
1170562004818	Cl binding site [ion binding]; other site
1170562004819	aspartate ring; other site
1170562004820	basic sphincter; other site
1170562004821	putative hydrophobic gate; other site
1170562004822	periplasmic entrance; other site
1170562004823	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
1170562004824	dsRNA-specific ribonuclease [Transcription]; Region: Rnc; COG0571
1170562004825	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
1170562004826	dimerization interface [polypeptide binding]; other site
1170562004827	active site
1170562004828	metal binding site [ion binding]; metal-binding site
1170562004829	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
1170562004830	dsRNA binding site [nucleotide binding]; other site
1170562004831	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1170562004832	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1170562004833	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1170562004834	Myxococcus xanthus DevT and related proteins, metallophosphatase domain; Region: MPP_DevT; cd07397
1170562004835	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1170562004836	putative active site [active]
1170562004837	putative metal binding site [ion binding]; other site
1170562004838	quinolinate synthetase; Provisional; Region: PRK09375
1170562004839	extracellular substrate-binding orphan protein, GRRM family; Region: orph_peri_GRRM; TIGR04262
1170562004840	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1170562004841	substrate binding pocket [chemical binding]; other site
1170562004842	membrane-bound complex binding site; other site
1170562004843	hinge residues; other site
1170562004844	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
1170562004845	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
1170562004846	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1170562004847	Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320
1170562004848	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
1170562004849	putative NAD(P) binding site [chemical binding]; other site
1170562004850	active site
1170562004851	putative substrate binding site [chemical binding]; other site
1170562004852	2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase  FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742
1170562004853	FMN binding site [chemical binding]; other site
1170562004854	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
1170562004855	substrate binding site [chemical binding]; other site
1170562004856	putative catalytic residue [active]
1170562004857	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
1170562004858	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1170562004859	active site
1170562004860	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1170562004861	active site
1170562004862	Acyl transferase domain; Region: Acyl_transf_1; cl08282
1170562004863	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1170562004864	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
1170562004865	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
1170562004866	putative NADP binding site [chemical binding]; other site
1170562004867	active site
1170562004868	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1170562004869	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1170562004870	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
1170562004871	active site
1170562004872	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
1170562004873	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1170562004874	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
1170562004875	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1170562004876	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1170562004877	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
1170562004878	catalytic residues [active]
1170562004879	catalytic nucleophile [active]
1170562004880	WYL domain; Region: WYL; pfam13280
1170562004881	Protein of unknown function (DUF433); Region: DUF433; pfam04255
1170562004882	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1170562004883	CRISPR-associated helicase Cas3, subtype CYANO; Region: cas3_cyano; TIGR03158
1170562004884	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
1170562004885	active site
1170562004886	NTP binding site [chemical binding]; other site
1170562004887	metal binding triad [ion binding]; metal-binding site
1170562004888	antibiotic binding site [chemical binding]; other site
1170562004889	Protein of unknown function DUF86; Region: DUF86; pfam01934
1170562004890	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
1170562004891	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
1170562004892	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
1170562004893	CRISPR/Cas system-associated protein Cas10d; Region: Cas10d_I-D; cd09712
1170562004894	CRISPR type I-D/CYANO-associated protein Csc3/Cas10d; Region: cas_Csc3; TIGR03174
1170562004895	CRISPR/Cas system-associated protein Csc2; Region: Csc2_I-D; cd09709
1170562004896	CRISPR/Cas system-associated protein Csc1; Region: Csc1_I-D; cd09711
1170562004897	CRISPR type I-D/CYANO-associated protein Csc1; Region: cas_Csc1; TIGR03159
1170562004898	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652
1170562004899	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637
1170562004900	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
1170562004901	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
1170562004902	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
1170562004903	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
1170562004904	ParB-like nuclease domain; Region: ParB; smart00470
1170562004905	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
1170562004906	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
1170562004907	HlyD family secretion protein; Region: HlyD_3; pfam13437
1170562004908	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1170562004909	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1170562004910	NAD(P) binding site [chemical binding]; other site
1170562004911	active site
1170562004912	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1170562004913	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
1170562004914	active site
1170562004915	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1170562004916	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1170562004917	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4704
1170562004918	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1170562004919	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
1170562004920	L-type amino acid transporter; Region: 2A0308; TIGR00911
1170562004921	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1170562004922	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1170562004923	S-adenosylmethionine binding site [chemical binding]; other site
1170562004924	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562004925	CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206
1170562004926	FeoA domain; Region: FeoA; pfam04023
1170562004927	nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376
1170562004928	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
1170562004929	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
1170562004930	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
1170562004931	High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672
1170562004932	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
1170562004933	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1170562004934	active site
1170562004935	metal binding site [ion binding]; metal-binding site
1170562004936	hexamer interface [polypeptide binding]; other site
1170562004937	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1170562004938	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562004939	dimer interface [polypeptide binding]; other site
1170562004940	phosphorylation site [posttranslational modification]
1170562004941	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562004942	ATP binding site [chemical binding]; other site
1170562004943	Mg2+ binding site [ion binding]; other site
1170562004944	G-X-G motif; other site
1170562004945	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1170562004946	putative active site [active]
1170562004947	Acid Phosphatase; Region: Acid_PPase; cl17256
1170562004948	seryl-tRNA synthetase; Provisional; Region: PRK05431
1170562004949	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
1170562004950	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
1170562004951	dimer interface [polypeptide binding]; other site
1170562004952	active site
1170562004953	motif 1; other site
1170562004954	motif 2; other site
1170562004955	motif 3; other site
1170562004956	Protein of unknown function (DUF3611); Region: DUF3611; pfam12263
1170562004957	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
1170562004958	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
1170562004959	protein-splicing catalytic site; other site
1170562004960	thioester formation/cholesterol transfer; other site
1170562004961	Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372
1170562004962	Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305
1170562004963	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
1170562004964	Predicted membrane protein [Function unknown]; Region: COG4371
1170562004965	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1170562004966	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1170562004967	active site
1170562004968	ATP binding site [chemical binding]; other site
1170562004969	substrate binding site [chemical binding]; other site
1170562004970	activation loop (A-loop); other site
1170562004971	Uncharacterized conserved protein [Function unknown]; Region: COG1262
1170562004972	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
1170562004973	glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534
1170562004974	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1170562004975	Glucose-6-P dehydrogenase subunit [Carbohydrate transport and metabolism]; Region: COG3429
1170562004976	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
1170562004977	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
1170562004978	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
1170562004979	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
1170562004980	AMP binding site [chemical binding]; other site
1170562004981	metal binding site [ion binding]; metal-binding site
1170562004982	active site
1170562004983	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
1170562004984	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
1170562004985	Leucine rich repeat; Region: LRR_8; pfam13855
1170562004986	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
1170562004987	Leucine rich repeat; Region: LRR_8; pfam13855
1170562004988	Leucine-rich repeats; other site
1170562004989	Substrate binding site [chemical binding]; other site
1170562004990	Leucine rich repeat; Region: LRR_8; pfam13855
1170562004991	Leucine rich repeat; Region: LRR_8; pfam13855
1170562004992	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
1170562004993	Leucine-rich repeats; other site
1170562004994	Substrate binding site [chemical binding]; other site
1170562004995	Leucine rich repeat; Region: LRR_8; pfam13855
1170562004996	Leucine rich repeat; Region: LRR_8; pfam13855
1170562004997	Leucine rich repeat; Region: LRR_8; pfam13855
1170562004998	Leucine rich repeat; Region: LRR_8; pfam13855
1170562004999	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
1170562005000	Leucine rich repeat; Region: LRR_8; pfam13855
1170562005001	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
1170562005002	Ras of complex proteins (Roc) C-terminal of Roc (COR) domain family; Region: RocCOR; cd09914
1170562005003	G1 box; other site
1170562005004	GTP/Mg2+ binding site [chemical binding]; other site
1170562005005	G2 box; other site
1170562005006	Switch I region; other site
1170562005007	G3 box; other site
1170562005008	Switch II region; other site
1170562005009	G4 box; other site
1170562005010	G5 box; other site
1170562005011	Condensation domain; Region: Condensation; pfam00668
1170562005012	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1170562005013	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
1170562005014	acyl-activating enzyme (AAE) consensus motif; other site
1170562005015	AMP binding site [chemical binding]; other site
1170562005016	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1170562005017	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
1170562005018	Uncharacterized ABC-type transport system, permease components [General function prediction only]; Region: COG3932
1170562005019	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1170562005020	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
1170562005021	magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030
1170562005022	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1170562005023	Walker A motif; other site
1170562005024	ATP binding site [chemical binding]; other site
1170562005025	Walker B motif; other site
1170562005026	arginine finger; other site
1170562005027	Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240
1170562005028	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
1170562005029	metal ion-dependent adhesion site (MIDAS); other site
1170562005030	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1170562005031	putative active site [active]
1170562005032	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1170562005033	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1170562005034	active site
1170562005035	ATP binding site [chemical binding]; other site
1170562005036	substrate binding site [chemical binding]; other site
1170562005037	activation loop (A-loop); other site
1170562005038	Uncharacterized conserved protein [Function unknown]; Region: COG1262
1170562005039	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
1170562005040	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1170562005041	putative active site [active]
1170562005042	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562005043	binding surface
1170562005044	TPR motif; other site
1170562005045	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562005046	Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156
1170562005047	active site
1170562005048	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562005049	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
1170562005050	ATP-grasp domain; Region: ATP-grasp; pfam02222
1170562005051	Predicted transcriptional regulators [Transcription]; Region: COG1695
1170562005052	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1170562005053	Protein of unknown function (DUF3529); Region: DUF3529; pfam12046
1170562005054	Protein of unknown function (DUF3155); Region: DUF3155; pfam11352
1170562005055	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1170562005056	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562005057	dimer interface [polypeptide binding]; other site
1170562005058	phosphorylation site [posttranslational modification]
1170562005059	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562005060	ATP binding site [chemical binding]; other site
1170562005061	Mg2+ binding site [ion binding]; other site
1170562005062	G-X-G motif; other site
1170562005063	50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926
1170562005064	G1 box; other site
1170562005065	GTP/Mg2+ binding site [chemical binding]; other site
1170562005066	G2 box; other site
1170562005067	Switch I region; other site
1170562005068	G3 box; other site
1170562005069	Switch II region; other site
1170562005070	Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597
1170562005071	DALR anticodon binding domain; Region: DALR_1; smart00836
1170562005072	anticodon binding site; other site
1170562005073	tRNA binding surface [nucleotide binding]; other site
1170562005074	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1170562005075	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1170562005076	putative switch regulator; other site
1170562005077	non-specific DNA interactions [nucleotide binding]; other site
1170562005078	DNA binding site [nucleotide binding]
1170562005079	sequence specific DNA binding site [nucleotide binding]; other site
1170562005080	putative cAMP binding site [chemical binding]; other site
1170562005081	PBP superfamily domain; Region: PBP_like_2; cl17296
1170562005082	TPR repeat; Region: TPR_11; pfam13414
1170562005083	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1170562005084	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344
1170562005085	putative ligand binding site [chemical binding]; other site
1170562005086	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1170562005087	active site
1170562005088	ATP binding site [chemical binding]; other site
1170562005089	substrate binding site [chemical binding]; other site
1170562005090	activation loop (A-loop); other site
1170562005091	LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180
1170562005092	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1170562005093	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
1170562005094	putative dimerization interface [polypeptide binding]; other site
1170562005095	Predicted membrane protein [Function unknown]; Region: COG4094
1170562005096	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1170562005097	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1170562005098	catalytic residues [active]
1170562005099	NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376
1170562005100	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
1170562005101	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1170562005102	NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010
1170562005103	NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK02546
1170562005104	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1170562005105	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
1170562005106	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562005107	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562005108	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562005109	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562005110	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562005111	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562005112	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562005113	TPR repeat; Region: TPR_11; pfam13414
1170562005114	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562005115	TPR motif; other site
1170562005116	binding surface
1170562005117	TPR repeat; Region: TPR_11; pfam13414
1170562005118	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562005119	binding surface
1170562005120	TPR motif; other site
1170562005121	TPR repeat; Region: TPR_11; pfam13414
1170562005122	TPR repeat; Region: TPR_11; pfam13414
1170562005123	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562005124	binding surface
1170562005125	TPR repeat; Region: TPR_11; pfam13414
1170562005126	TPR motif; other site
1170562005127	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1170562005128	Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967
1170562005129	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
1170562005130	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
1170562005131	bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109
1170562005132	Moco binding site; other site
1170562005133	metal coordination site [ion binding]; other site
1170562005134	ribosomal protein L32; Validated; Region: rpl32; CHL00152
1170562005135	Caspase domain; Region: Peptidase_C14; pfam00656
1170562005136	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
1170562005137	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983
1170562005138	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
1170562005139	catalytic triad [active]
1170562005140	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1170562005141	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
1170562005142	Probable transposase; Region: OrfB_IS605; pfam01385
1170562005143	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
1170562005144	GTPase RsgA; Reviewed; Region: PRK12289
1170562005145	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1170562005146	RNA binding site [nucleotide binding]; other site
1170562005147	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
1170562005148	GTPase/Zn-binding domain interface [polypeptide binding]; other site
1170562005149	GTP/Mg2+ binding site [chemical binding]; other site
1170562005150	G4 box; other site
1170562005151	G5 box; other site
1170562005152	G1 box; other site
1170562005153	Switch I region; other site
1170562005154	G2 box; other site
1170562005155	G3 box; other site
1170562005156	Switch II region; other site
1170562005157	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
1170562005158	CPxP  motif; other site
1170562005159	chaperone protein DnaJ; Provisional; Region: PRK14293
1170562005160	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1170562005161	HSP70 interaction site [polypeptide binding]; other site
1170562005162	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
1170562005163	substrate binding site [polypeptide binding]; other site
1170562005164	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1170562005165	Zn binding sites [ion binding]; other site
1170562005166	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1170562005167	dimer interface [polypeptide binding]; other site
1170562005168	molecular chaperone DnaK; Provisional; Region: PRK13411
1170562005169	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
1170562005170	nucleotide binding site [chemical binding]; other site
1170562005171	NEF interaction site [polypeptide binding]; other site
1170562005172	SBD interface [polypeptide binding]; other site
1170562005173	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
1170562005174	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
1170562005175	dimer interface [polypeptide binding]; other site
1170562005176	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
1170562005177	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
1170562005178	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
1170562005179	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
1170562005180	Walker A motif; other site
1170562005181	ATP binding site [chemical binding]; other site
1170562005182	Walker B motif; other site
1170562005183	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
1170562005184	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
1170562005185	Walker A motif; other site
1170562005186	ATP binding site [chemical binding]; other site
1170562005187	Walker B motif; other site
1170562005188	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
1170562005189	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1170562005190	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1170562005191	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1170562005192	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1170562005193	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
1170562005194	Peptidase family M50; Region: Peptidase_M50; pfam02163
1170562005195	active site
1170562005196	putative substrate binding region [chemical binding]; other site
1170562005197	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1170562005198	carboxyl-terminal processing protease; Provisional; Region: PLN00049
1170562005199	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
1170562005200	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
1170562005201	protein binding site [polypeptide binding]; other site
1170562005202	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
1170562005203	Catalytic dyad [active]
1170562005204	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
1170562005205	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
1170562005206	Qi binding site; other site
1170562005207	intrachain domain interface; other site
1170562005208	interchain domain interface [polypeptide binding]; other site
1170562005209	heme bH binding site [chemical binding]; other site
1170562005210	heme bL binding site [chemical binding]; other site
1170562005211	Qo binding site; other site
1170562005212	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
1170562005213	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
1170562005214	interchain domain interface [polypeptide binding]; other site
1170562005215	intrachain domain interface; other site
1170562005216	Qi binding site; other site
1170562005217	Qo binding site; other site
1170562005218	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
1170562005219	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
1170562005220	Mg2+ binding site [ion binding]; other site
1170562005221	G-X-G motif; other site
1170562005222	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
1170562005223	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
1170562005224	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1170562005225	Patatin-like phospholipase; includes PNPLA8, PNPLA9, and Pat17; Region: Pat17_PNPLA8_PNPLA9_like; cd07199
1170562005226	active site
1170562005227	nucleophile elbow; other site
1170562005228	Patatin-like phospholipase; includes PNPLA8, PNPLA9, and Pat17; Region: Pat17_PNPLA8_PNPLA9_like; cd07199
1170562005229	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1170562005230	homodimer interface [polypeptide binding]; other site
1170562005231	substrate-cofactor binding pocket; other site
1170562005232	Aminotransferase class IV; Region: Aminotran_4; pfam01063
1170562005233	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1170562005234	catalytic residue [active]
1170562005235	FtsH Extracellular; Region: FtsH_ext; pfam06480
1170562005236	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
1170562005237	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1170562005238	Walker A motif; other site
1170562005239	ATP binding site [chemical binding]; other site
1170562005240	Walker B motif; other site
1170562005241	arginine finger; other site
1170562005242	Peptidase family M41; Region: Peptidase_M41; pfam01434
1170562005243	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
1170562005244	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
1170562005245	active site
1170562005246	homodimer interface [polypeptide binding]; other site
1170562005247	catalytic site [active]
1170562005248	Protein of unknown function (DUF3318); Region: DUF3318; pfam11780
1170562005249	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1170562005250	NMT1-like family; Region: NMT1_2; pfam13379
1170562005251	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1170562005252	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
1170562005253	Walker A/P-loop; other site
1170562005254	ATP binding site [chemical binding]; other site
1170562005255	Q-loop/lid; other site
1170562005256	ABC transporter signature motif; other site
1170562005257	Walker B; other site
1170562005258	D-loop; other site
1170562005259	H-loop/switch region; other site
1170562005260	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1170562005261	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1170562005262	dimer interface [polypeptide binding]; other site
1170562005263	conserved gate region; other site
1170562005264	putative PBP binding loops; other site
1170562005265	ABC-ATPase subunit interface; other site
1170562005266	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
1170562005267	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
1170562005268	substrate binding site; other site
1170562005269	Predicted dehydrogenase [General function prediction only]; Region: COG0579
1170562005270	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1170562005271	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
1170562005272	extended (e) SDRs; Region: SDR_e; cd08946
1170562005273	NAD(P) binding site [chemical binding]; other site
1170562005274	active site
1170562005275	substrate binding site [chemical binding]; other site
1170562005276	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1170562005277	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1170562005278	active site
1170562005279	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
1170562005280	Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091
1170562005281	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1170562005282	SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616
1170562005283	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1170562005284	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
1170562005285	putative ADP-binding pocket [chemical binding]; other site
1170562005286	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
1170562005287	Chain length determinant protein; Region: Wzz; pfam02706
1170562005288	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
1170562005289	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
1170562005290	Bacterial sugar transferase; Region: Bac_transf; cl00939
1170562005291	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1170562005292	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1170562005293	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
1170562005294	Walker A/P-loop; other site
1170562005295	ATP binding site [chemical binding]; other site
1170562005296	Q-loop/lid; other site
1170562005297	ABC transporter signature motif; other site
1170562005298	Walker B; other site
1170562005299	D-loop; other site
1170562005300	H-loop/switch region; other site
1170562005301	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1170562005302	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
1170562005303	active site
1170562005304	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1170562005305	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
1170562005306	active site
1170562005307	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1170562005308	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1170562005309	active site
1170562005310	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1170562005311	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1170562005312	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1170562005313	O-Antigen ligase; Region: Wzy_C; cl04850
1170562005314	Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248
1170562005315	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1170562005316	substrate binding site [chemical binding]; other site
1170562005317	activation loop (A-loop); other site
1170562005318	TPR repeat; Region: TPR_11; pfam13414
1170562005319	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562005320	binding surface
1170562005321	TPR motif; other site
1170562005322	TPR repeat; Region: TPR_11; pfam13414
1170562005323	TPR repeat; Region: TPR_11; pfam13414
1170562005324	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562005325	TPR motif; other site
1170562005326	TPR repeat; Region: TPR_11; pfam13414
1170562005327	binding surface
1170562005328	Protein phosphatase 2C; Region: PP2C_2; pfam13672
1170562005329	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
1170562005330	metal ion-dependent adhesion site (MIDAS); other site
1170562005331	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562005332	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562005333	active site
1170562005334	phosphorylation site [posttranslational modification]
1170562005335	intermolecular recognition site; other site
1170562005336	dimerization interface [polypeptide binding]; other site
1170562005337	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562005338	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562005339	active site
1170562005340	phosphorylation site [posttranslational modification]
1170562005341	intermolecular recognition site; other site
1170562005342	dimerization interface [polypeptide binding]; other site
1170562005343	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
1170562005344	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1170562005345	Active Sites [active]
1170562005346	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1170562005347	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1170562005348	TM-ABC transporter signature motif; other site
1170562005349	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1170562005350	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1170562005351	Walker A/P-loop; other site
1170562005352	ATP binding site [chemical binding]; other site
1170562005353	Q-loop/lid; other site
1170562005354	ABC transporter signature motif; other site
1170562005355	Walker B; other site
1170562005356	D-loop; other site
1170562005357	H-loop/switch region; other site
1170562005358	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1170562005359	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1170562005360	Walker A/P-loop; other site
1170562005361	ATP binding site [chemical binding]; other site
1170562005362	Q-loop/lid; other site
1170562005363	ABC transporter signature motif; other site
1170562005364	Walker B; other site
1170562005365	D-loop; other site
1170562005366	H-loop/switch region; other site
1170562005367	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343
1170562005368	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
1170562005369	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
1170562005370	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1170562005371	dimerization interface [polypeptide binding]; other site
1170562005372	putative DNA binding site [nucleotide binding]; other site
1170562005373	putative Zn2+ binding site [ion binding]; other site
1170562005374	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1170562005375	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1170562005376	catalytic residues [active]
1170562005377	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1170562005378	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
1170562005379	FMN binding site [chemical binding]; other site
1170562005380	active site
1170562005381	substrate binding site [chemical binding]; other site
1170562005382	catalytic residue [active]
1170562005383	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
1170562005384	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1170562005385	Walker A/P-loop; other site
1170562005386	ATP binding site [chemical binding]; other site
1170562005387	Q-loop/lid; other site
1170562005388	ABC transporter signature motif; other site
1170562005389	Walker B; other site
1170562005390	D-loop; other site
1170562005391	H-loop/switch region; other site
1170562005392	phycocyanobilin:ferredoxin oxidoreductase; Validated; Region: PRK02816
1170562005393	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1170562005394	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1170562005395	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1170562005396	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1170562005397	Walker A/P-loop; other site
1170562005398	ATP binding site [chemical binding]; other site
1170562005399	Q-loop/lid; other site
1170562005400	ABC transporter signature motif; other site
1170562005401	Walker B; other site
1170562005402	D-loop; other site
1170562005403	H-loop/switch region; other site
1170562005404	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1170562005405	TPR motif; other site
1170562005406	binding surface
1170562005407	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562005408	TPR motif; other site
1170562005409	binding surface
1170562005410	TPR repeat; Region: TPR_11; pfam13414
1170562005411	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562005412	binding surface
1170562005413	TPR motif; other site
1170562005414	TPR repeat; Region: TPR_11; pfam13414
1170562005415	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562005416	binding surface
1170562005417	TPR motif; other site
1170562005418	TPR repeat; Region: TPR_11; pfam13414
1170562005419	TPR repeat; Region: TPR_11; pfam13414
1170562005420	threonine synthase; Validated; Region: PRK07591
1170562005421	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
1170562005422	homodimer interface [polypeptide binding]; other site
1170562005423	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1170562005424	catalytic residue [active]
1170562005425	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
1170562005426	MoaE interaction surface [polypeptide binding]; other site
1170562005427	MoeB interaction surface [polypeptide binding]; other site
1170562005428	thiocarboxylated glycine; other site
1170562005429	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
1170562005430	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1170562005431	NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561
1170562005432	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1170562005433	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1170562005434	substrate binding site [chemical binding]; other site
1170562005435	activation loop (A-loop); other site
1170562005436	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1170562005437	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1170562005438	active site
1170562005439	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1170562005440	putative lipid kinase; Reviewed; Region: PRK13057
1170562005441	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
1170562005442	active site
1170562005443	dimer interface [polypeptide binding]; other site
1170562005444	metal binding site [ion binding]; metal-binding site
1170562005445	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
1170562005446	circadian clock protein KaiC; Region: circ_KaiC; TIGR02655
1170562005447	KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124
1170562005448	Walker A motif; other site
1170562005449	ATP binding site [chemical binding]; other site
1170562005450	Walker B motif; other site
1170562005451	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1170562005452	ATP binding site [chemical binding]; other site
1170562005453	Walker B motif; other site
1170562005454	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
1170562005455	tetramer interface [polypeptide binding]; other site
1170562005456	dimer interface [polypeptide binding]; other site
1170562005457	KaiA domain; Region: KaiA; pfam07688
1170562005458	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1170562005459	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562005460	dimer interface [polypeptide binding]; other site
1170562005461	phosphorylation site [posttranslational modification]
1170562005462	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562005463	ATP binding site [chemical binding]; other site
1170562005464	Mg2+ binding site [ion binding]; other site
1170562005465	G-X-G motif; other site
1170562005466	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1170562005467	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562005468	active site
1170562005469	phosphorylation site [posttranslational modification]
1170562005470	intermolecular recognition site; other site
1170562005471	dimerization interface [polypeptide binding]; other site
1170562005472	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
1170562005473	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
1170562005474	Domain of unknown function DUF29; Region: DUF29; pfam01724
1170562005475	Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402
1170562005476	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
1170562005477	dimer interface [polypeptide binding]; other site
1170562005478	catalytic triad [active]
1170562005479	Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081
1170562005480	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1170562005481	Walker A motif; other site
1170562005482	ATP binding site [chemical binding]; other site
1170562005483	SnoaL-like domain; Region: SnoaL_2; pfam12680
1170562005484	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
1170562005485	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
1170562005486	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1170562005487	FeS/SAM binding site; other site
1170562005488	Domain of unknown function (DUF1830); Region: DUF1830; pfam08865
1170562005489	Bacterial SH3 domain; Region: SH3_3; cl17532
1170562005490	phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315
1170562005491	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1170562005492	Walker A/P-loop; other site
1170562005493	ATP binding site [chemical binding]; other site
1170562005494	Q-loop/lid; other site
1170562005495	ABC transporter signature motif; other site
1170562005496	Walker B; other site
1170562005497	D-loop; other site
1170562005498	Putative restriction endonuclease; Region: Uma2; pfam05685
1170562005499	Double-stranded DNA-binding domain; Region: dsDNA_bind; cl00928
1170562005500	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1170562005501	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1170562005502	Walker A/P-loop; other site
1170562005503	ATP binding site [chemical binding]; other site
1170562005504	Q-loop/lid; other site
1170562005505	ABC transporter signature motif; other site
1170562005506	Walker B; other site
1170562005507	D-loop; other site
1170562005508	H-loop/switch region; other site
1170562005509	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270
1170562005510	active site
1170562005511	metal-binding site [ion binding]
1170562005512	nucleotide-binding site [chemical binding]; other site
1170562005513	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
1170562005514	active site
1170562005515	dimer interface [polypeptide binding]; other site
1170562005516	Glutamine amidotransferase domain; Region: GATase_6; pfam13522
1170562005517	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
1170562005518	Ligand Binding Site [chemical binding]; other site
1170562005519	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
1170562005520	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
1170562005521	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
1170562005522	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1170562005523	NAD(P) binding site [chemical binding]; other site
1170562005524	putative active site [active]
1170562005525	Protein of unknown function (DUF1997); Region: DUF1997; pfam09366
1170562005526	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
1170562005527	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1170562005528	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
1170562005529	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1170562005530	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1170562005531	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1170562005532	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1170562005533	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1170562005534	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1170562005535	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1170562005536	TPR repeat; Region: TPR_11; pfam13414
1170562005537	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562005538	binding surface
1170562005539	TPR motif; other site
1170562005540	TPR repeat; Region: TPR_11; pfam13414
1170562005541	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
1170562005542	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562005543	binding surface
1170562005544	TPR motif; other site
1170562005545	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562005546	binding surface
1170562005547	TPR motif; other site
1170562005548	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562005549	binding surface
1170562005550	TPR motif; other site
1170562005551	CHAT domain; Region: CHAT; pfam12770
1170562005552	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1170562005553	Walker A motif; other site
1170562005554	ATP binding site [chemical binding]; other site
1170562005555	Walker B motif; other site
1170562005556	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
1170562005557	protein-splicing catalytic site; other site
1170562005558	thioester formation/cholesterol transfer; other site
1170562005559	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
1170562005560	protein-splicing catalytic site; other site
1170562005561	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948
1170562005562	DNA polymerase III subunit delta'; Validated; Region: PRK08485
1170562005563	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
1170562005564	Predicted membrane protein [Function unknown]; Region: COG3374
1170562005565	Protein of unknown function (DUF981); Region: DUF981; pfam06168
1170562005566	S-layer homology domain; Region: SLH; pfam00395
1170562005567	S-layer homology domain; Region: SLH; pfam00395
1170562005568	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
1170562005569	Fasciclin domain; Region: Fasciclin; pfam02469
1170562005570	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
1170562005571	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
1170562005572	DXD motif; other site
1170562005573	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
1170562005574	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1170562005575	FeS/SAM binding site; other site
1170562005576	BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857
1170562005577	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1170562005578	DRTGG domain; Region: DRTGG; pfam07085
1170562005579	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
1170562005580	Predicted transcriptional regulators [Transcription]; Region: COG1695
1170562005581	Transcriptional regulator PadR-like family; Region: PadR; cl17335
1170562005582	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
1170562005583	MAPEG family; Region: MAPEG; cl09190
1170562005584	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
1170562005585	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
1170562005586	Rieske non-heme iron oxygenase (RO) family, Pheophorbide a oxygenase (PaO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of a small subfamily of enzymes found in plants as well as oxygenic...; Region: Rieske_RO_Alpha_PaO; cd03480
1170562005587	pheophorbide a oxygenase; Region: PLN02518
1170562005588	Pheophorbide a oxygenase; Region: PaO; pfam08417
1170562005589	UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236
1170562005590	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
1170562005591	active site
1170562005592	homodimer interface [polypeptide binding]; other site
1170562005593	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1170562005594	Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483
1170562005595	HEAT repeats; Region: HEAT_2; pfam13646
1170562005596	HEAT repeat; Region: HEAT; pfam02985
1170562005597	HEAT repeats; Region: HEAT_2; pfam13646
1170562005598	HEAT repeats; Region: HEAT_2; pfam13646
1170562005599	HEAT repeats; Region: HEAT_2; pfam13646
1170562005600	PBS lyase HEAT-like repeat; Region: HEAT_PBS; pfam03130
1170562005601	muropeptide transporter; Validated; Region: ampG; cl17669
1170562005602	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1170562005603	putative active site [active]
1170562005604	DNA phosphorothioation-associated putative methyltransferase; Region: dnd_rel_methyl; TIGR04096
1170562005605	Domain of unknown function (DUF1832); Region: DUF1832; pfam08870
1170562005606	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
1170562005607	homodimer interface [polypeptide binding]; other site
1170562005608	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1170562005609	catalytic residue [active]
1170562005610	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
1170562005611	active site
1170562005612	ribulose/triose binding site [chemical binding]; other site
1170562005613	phosphate binding site [ion binding]; other site
1170562005614	substrate (anthranilate) binding pocket [chemical binding]; other site
1170562005615	product (indole) binding pocket [chemical binding]; other site
1170562005616	Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150
1170562005617	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
1170562005618	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348
1170562005619	Homeodomain-like domain; Region: HTH_23; pfam13384
1170562005620	Winged helix-turn helix; Region: HTH_29; pfam13551
1170562005621	Winged helix-turn helix; Region: HTH_33; pfam13592
1170562005622	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1170562005623	ligand binding site [chemical binding]; other site
1170562005624	flexible hinge region; other site
1170562005625	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
1170562005626	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
1170562005627	putative active site [active]
1170562005628	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1170562005629	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1170562005630	Walker A/P-loop; other site
1170562005631	ATP binding site [chemical binding]; other site
1170562005632	Q-loop/lid; other site
1170562005633	ABC transporter signature motif; other site
1170562005634	Walker B; other site
1170562005635	D-loop; other site
1170562005636	H-loop/switch region; other site
1170562005637	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
1170562005638	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1170562005639	HlyD family secretion protein; Region: HlyD_3; pfam13437
1170562005640	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1170562005641	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
1170562005642	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
1170562005643	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1170562005644	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1170562005645	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1170562005646	active site
1170562005647	catalytic tetrad [active]
1170562005648	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1170562005649	Phosphotransferase enzyme family; Region: APH; pfam01636
1170562005650	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
1170562005651	active site
1170562005652	dimer interface [polypeptide binding]; other site
1170562005653	Glutamine amidotransferase domain; Region: GATase_6; pfam13522
1170562005654	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
1170562005655	Ligand Binding Site [chemical binding]; other site
1170562005656	Molecular Tunnel; other site
1170562005657	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
1170562005658	HprK-related kinase A; Region: HprK_rel_A; TIGR04352
1170562005659	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1170562005660	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1170562005661	Walker A/P-loop; other site
1170562005662	ATP binding site [chemical binding]; other site
1170562005663	Q-loop/lid; other site
1170562005664	ABC transporter signature motif; other site
1170562005665	Walker B; other site
1170562005666	D-loop; other site
1170562005667	H-loop/switch region; other site
1170562005668	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
1170562005669	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
1170562005670	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
1170562005671	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1170562005672	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1170562005673	dimer interface [polypeptide binding]; other site
1170562005674	conserved gate region; other site
1170562005675	putative PBP binding loops; other site
1170562005676	ABC-ATPase subunit interface; other site
1170562005677	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1170562005678	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519
1170562005679	photosystem II 47 kDa protein; Region: psbB; CHL00062
1170562005680	photosystem II reaction center protein T; Reviewed; Region: psbT; PRK11875
1170562005681	30S ribosomal protein S1; Reviewed; Region: PRK07400
1170562005682	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
1170562005683	RNA binding site [nucleotide binding]; other site
1170562005684	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
1170562005685	RNA binding site [nucleotide binding]; other site
1170562005686	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
1170562005687	RNA binding site [nucleotide binding]; other site
1170562005688	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1170562005689	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1170562005690	motif II; other site
1170562005691	aspartate aminotransferase; Provisional; Region: PRK05957
1170562005692	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1170562005693	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1170562005694	homodimer interface [polypeptide binding]; other site
1170562005695	catalytic residue [active]
1170562005696	CpeS-like protein; Region: CpeS; pfam09367
1170562005697	HEAT repeats; Region: HEAT_2; pfam13646
1170562005698	HEAT repeats; Region: HEAT_2; pfam13646
1170562005699	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
1170562005700	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
1170562005701	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1170562005702	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
1170562005703	ThiS interaction site; other site
1170562005704	putative active site [active]
1170562005705	tetramer interface [polypeptide binding]; other site
1170562005706	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
1170562005707	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1170562005708	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
1170562005709	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1170562005710	Walker A motif; other site
1170562005711	ATP binding site [chemical binding]; other site
1170562005712	Walker B motif; other site
1170562005713	arginine finger; other site
1170562005714	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
1170562005715	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
1170562005716	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1170562005717	substrate binding site [chemical binding]; other site
1170562005718	glutamase interaction surface [polypeptide binding]; other site
1170562005719	AAA domain; Region: AAA_22; pfam13401
1170562005720	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
1170562005721	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
1170562005722	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1170562005723	ATP binding site [chemical binding]; other site
1170562005724	putative Mg++ binding site [ion binding]; other site
1170562005725	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1170562005726	nucleotide binding region [chemical binding]; other site
1170562005727	ATP-binding site [chemical binding]; other site
1170562005728	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
1170562005729	Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967
1170562005730	Protein of unknown function (DUF861); Region: Cupin_3; pfam05899
1170562005731	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562005732	binding surface
1170562005733	TPR motif; other site
1170562005734	TPR repeat; Region: TPR_11; pfam13414
1170562005735	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562005736	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562005737	binding surface
1170562005738	TPR motif; other site
1170562005739	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562005740	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562005741	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562005742	binding surface
1170562005743	TPR motif; other site
1170562005744	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562005745	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562005746	binding surface
1170562005747	TPR motif; other site
1170562005748	TPR repeat; Region: TPR_11; pfam13414
1170562005749	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562005750	CHAT domain; Region: CHAT; pfam12770
1170562005751	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
1170562005752	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
1170562005753	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
1170562005754	MutS domain I; Region: MutS_I; pfam01624
1170562005755	MutS domain II; Region: MutS_II; pfam05188
1170562005756	MutS domain III; Region: MutS_III; pfam05192
1170562005757	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
1170562005758	Walker A/P-loop; other site
1170562005759	ATP binding site [chemical binding]; other site
1170562005760	Q-loop/lid; other site
1170562005761	ABC transporter signature motif; other site
1170562005762	Walker B; other site
1170562005763	D-loop; other site
1170562005764	H-loop/switch region; other site
1170562005765	Protein of unknown function (DUF1696); Region: DUF1696; pfam08000
1170562005766	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
1170562005767	light-harvesting-like protein 3; Provisional; Region: PLN00014
1170562005768	Thymidylate synthase complementing protein; Region: Thy1; cl03630
1170562005769	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl17442
1170562005770	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1170562005771	active site
1170562005772	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
1170562005773	protein-splicing catalytic site; other site
1170562005774	Thymidylate synthase complementing protein; Region: Thy1; cl03630
1170562005775	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
1170562005776	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
1170562005777	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
1170562005778	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
1170562005779	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
1170562005780	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
1170562005781	NADP-binding site; other site
1170562005782	homotetramer interface [polypeptide binding]; other site
1170562005783	substrate binding site [chemical binding]; other site
1170562005784	homodimer interface [polypeptide binding]; other site
1170562005785	active site
1170562005786	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1170562005787	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1170562005788	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1170562005789	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1170562005790	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
1170562005791	Walker A/P-loop; other site
1170562005792	ATP binding site [chemical binding]; other site
1170562005793	Q-loop/lid; other site
1170562005794	ABC transporter signature motif; other site
1170562005795	Walker B; other site
1170562005796	D-loop; other site
1170562005797	H-loop/switch region; other site
1170562005798	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1170562005799	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1170562005800	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
1170562005801	AMIN domain; Region: AMIN; pfam11741
1170562005802	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
1170562005803	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
1170562005804	DinB family; Region: DinB; cl17821
1170562005805	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1170562005806	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1170562005807	Coenzyme A binding pocket [chemical binding]; other site
1170562005808	Nitrogen regulatory protein P-II; Region: P-II; cl00412
1170562005809	Peptidase S8 family domain in Kp43 proteases; Region: Peptidases_S8_Kp43_protease; cd04842
1170562005810	active site
1170562005811	catalytic triad [active]
1170562005812	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
1170562005813	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
1170562005814	active site
1170562005815	substrate binding site [chemical binding]; other site
1170562005816	cosubstrate binding site; other site
1170562005817	catalytic site [active]
1170562005818	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1170562005819	dimerization interface [polypeptide binding]; other site
1170562005820	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330
1170562005821	short chain dehydrogenase; Validated; Region: PRK06182
1170562005822	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
1170562005823	NADP binding site [chemical binding]; other site
1170562005824	active site
1170562005825	steroid binding site; other site
1170562005826	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
1170562005827	4Fe-4S binding domain; Region: Fer4; pfam00037
1170562005828	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1170562005829	non-specific DNA binding site [nucleotide binding]; other site
1170562005830	salt bridge; other site
1170562005831	sequence-specific DNA binding site [nucleotide binding]; other site
1170562005832	ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936
1170562005833	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
1170562005834	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
1170562005835	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
1170562005836	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
1170562005837	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1170562005838	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
1170562005839	catalytic residues [active]
1170562005840	catalytic nucleophile [active]
1170562005841	Recombinase; Region: Recombinase; pfam07508
1170562005842	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
1170562005843	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1170562005844	dimerization interface [polypeptide binding]; other site
1170562005845	putative DNA binding site [nucleotide binding]; other site
1170562005846	putative Zn2+ binding site [ion binding]; other site
1170562005847	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1170562005848	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1170562005849	dimer interface [polypeptide binding]; other site
1170562005850	conserved gate region; other site
1170562005851	putative PBP binding loops; other site
1170562005852	ABC-ATPase subunit interface; other site
1170562005853	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1170562005854	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
1170562005855	Walker A/P-loop; other site
1170562005856	ATP binding site [chemical binding]; other site
1170562005857	Q-loop/lid; other site
1170562005858	ABC transporter signature motif; other site
1170562005859	Walker B; other site
1170562005860	D-loop; other site
1170562005861	H-loop/switch region; other site
1170562005862	RNA binding activity-knot of a chromodomain; Region: Tudor-knot; pfam11717
1170562005863	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
1170562005864	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1170562005865	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
1170562005866	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1170562005867	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562005868	active site
1170562005869	phosphorylation site [posttranslational modification]
1170562005870	intermolecular recognition site; other site
1170562005871	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
1170562005872	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
1170562005873	CHASE2 domain; Region: CHASE2; pfam05226
1170562005874	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1170562005875	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
1170562005876	TPR repeat; Region: TPR_11; pfam13414
1170562005877	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562005878	binding surface
1170562005879	TPR motif; other site
1170562005880	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562005881	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1170562005882	TPR motif; other site
1170562005883	binding surface
1170562005884	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
1170562005885	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
1170562005886	haemagglutination activity domain; Region: Haemagg_act; pfam05860
1170562005887	Peptidase S8 family domain in Thiazoline oxidase/subtilisin-like proteases; Region: Peptidases_S8_thiazoline_oxidase_subtilisin-like_p; cd07476
1170562005888	putative active site [active]
1170562005889	putative catalytic triad [active]
1170562005890	cyanobactin maturation protease, PatA/PatG family; Region: protease_PatA; TIGR03895
1170562005891	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
1170562005892	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
1170562005893	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1170562005894	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
1170562005895	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
1170562005896	Surface antigen; Region: Bac_surface_Ag; pfam01103
1170562005897	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1170562005898	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1170562005899	active site residue [active]
1170562005900	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
1170562005901	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1170562005902	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1170562005903	S-adenosylmethionine binding site [chemical binding]; other site
1170562005904	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
1170562005905	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
1170562005906	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
1170562005907	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
1170562005908	UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721
1170562005909	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1170562005910	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1170562005911	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
1170562005912	transmembrane helices; other site
1170562005913	glycerate kinase; Region: TIGR00045
1170562005914	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562005915	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562005916	active site
1170562005917	phosphorylation site [posttranslational modification]
1170562005918	intermolecular recognition site; other site
1170562005919	dimerization interface [polypeptide binding]; other site
1170562005920	S-layer homology domain; Region: SLH; pfam00395
1170562005921	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
1170562005922	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1170562005923	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1170562005924	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
1170562005925	Walker A/P-loop; other site
1170562005926	ATP binding site [chemical binding]; other site
1170562005927	Q-loop/lid; other site
1170562005928	ABC transporter signature motif; other site
1170562005929	Walker B; other site
1170562005930	D-loop; other site
1170562005931	H-loop/switch region; other site
1170562005932	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1170562005933	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
1170562005934	Walker A/P-loop; other site
1170562005935	ATP binding site [chemical binding]; other site
1170562005936	Q-loop/lid; other site
1170562005937	ABC transporter signature motif; other site
1170562005938	Walker B; other site
1170562005939	D-loop; other site
1170562005940	H-loop/switch region; other site
1170562005941	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1170562005942	NMT1-like family; Region: NMT1_2; pfam13379
1170562005943	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1170562005944	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1170562005945	dimer interface [polypeptide binding]; other site
1170562005946	conserved gate region; other site
1170562005947	putative PBP binding loops; other site
1170562005948	ABC-ATPase subunit interface; other site
1170562005949	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1170562005950	NMT1-like family; Region: NMT1_2; pfam13379
1170562005951	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1170562005952	TrkA-N domain; Region: TrkA_N; pfam02254
1170562005953	Ion channel; Region: Ion_trans_2; pfam07885
1170562005954	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
1170562005955	TrkA-N domain; Region: TrkA_N; pfam02254
1170562005956	TspO/MBR family; Region: TspO_MBR; cl01379
1170562005957	Uncharacterized conserved protein (DUF2267); Region: DUF2267; cl02314
1170562005958	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1170562005959	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562005960	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562005961	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562005962	hypothetical protein; Reviewed; Region: PRK12497
1170562005963	Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547
1170562005964	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
1170562005965	probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913
1170562005966	probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913
1170562005967	TPR repeat; Region: TPR_11; pfam13414
1170562005968	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562005969	binding surface
1170562005970	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1170562005971	TPR motif; other site
1170562005972	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
1170562005973	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562005974	binding surface
1170562005975	TPR motif; other site
1170562005976	TPR repeat; Region: TPR_11; pfam13414
1170562005977	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1170562005978	TrkA-N domain; Region: TrkA_N; pfam02254
1170562005979	TrkA-C domain; Region: TrkA_C; pfam02080
1170562005980	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
1170562005981	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
1170562005982	tocopherol O-methyltransferase; Region: PLN02244
1170562005983	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1170562005984	S-adenosylmethionine binding site [chemical binding]; other site
1170562005985	tocopherol phytyltransferase; Reviewed; Region: ubiA; PRK12887
1170562005986	UbiA prenyltransferase family; Region: UbiA; pfam01040
1170562005987	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1170562005988	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562005989	binding surface
1170562005990	TPR motif; other site
1170562005991	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
1170562005992	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1170562005993	Probable transposase; Region: OrfB_IS605; pfam01385
1170562005994	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
1170562005995	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
1170562005996	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1170562005997	C-terminal domain interface [polypeptide binding]; other site
1170562005998	GSH binding site (G-site) [chemical binding]; other site
1170562005999	dimer interface [polypeptide binding]; other site
1170562006000	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
1170562006001	N-terminal domain interface [polypeptide binding]; other site
1170562006002	dimer interface [polypeptide binding]; other site
1170562006003	substrate binding pocket (H-site) [chemical binding]; other site
1170562006004	S-layer homology domain; Region: SLH; pfam00395
1170562006005	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
1170562006006	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1170562006007	L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235
1170562006008	putative NAD(P) binding site [chemical binding]; other site
1170562006009	catalytic Zn binding site [ion binding]; other site
1170562006010	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562006011	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562006012	active site
1170562006013	phosphorylation site [posttranslational modification]
1170562006014	intermolecular recognition site; other site
1170562006015	dimerization interface [polypeptide binding]; other site
1170562006016	Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390
1170562006017	Predicted membrane protein [Function unknown]; Region: COG2261
1170562006018	3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13398
1170562006019	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
1170562006020	photosystem I reaction center subunit X; Reviewed; Region: PRK13214
1170562006021	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1170562006022	HlyD family secretion protein; Region: HlyD_3; pfam13437
1170562006023	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1170562006024	Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110
1170562006025	Moco binding site; other site
1170562006026	metal coordination site [ion binding]; other site
1170562006027	dimerization interface [polypeptide binding]; other site
1170562006028	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
1170562006029	putative rRNA binding site [nucleotide binding]; other site
1170562006030	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
1170562006031	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
1170562006032	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1170562006033	catalytic residue [active]
1170562006034	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1170562006035	Protein of unknown function (DUF3352); Region: DUF3352; pfam11832
1170562006036	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
1170562006037	Peptidase family M48; Region: Peptidase_M48; pfam01435
1170562006038	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
1170562006039	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
1170562006040	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1170562006041	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
1170562006042	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1170562006043	putative NAD(P) binding site [chemical binding]; other site
1170562006044	active site
1170562006045	putative substrate binding site [chemical binding]; other site
1170562006046	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1170562006047	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1170562006048	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1170562006049	Walker A/P-loop; other site
1170562006050	ATP binding site [chemical binding]; other site
1170562006051	Q-loop/lid; other site
1170562006052	ABC transporter signature motif; other site
1170562006053	Walker B; other site
1170562006054	D-loop; other site
1170562006055	H-loop/switch region; other site
1170562006056	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1170562006057	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
1170562006058	active site
1170562006059	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1170562006060	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1170562006061	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
1170562006062	Predicted glycosyl transferase [General function prediction only]; Region: COG4671
1170562006063	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1170562006064	Predicted glycosyl transferase [General function prediction only]; Region: COG4671
1170562006065	Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369
1170562006066	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
1170562006067	S-layer homology domain; Region: SLH; pfam00395
1170562006068	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
1170562006069	Protein of unknown function (DUF721); Region: DUF721; cl02324
1170562006070	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
1170562006071	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
1170562006072	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1170562006073	putative active site [active]
1170562006074	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1170562006075	catalytic residues [active]
1170562006076	succinyldiaminopimelate transaminase; Validated; Region: PRK07366
1170562006077	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1170562006078	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1170562006079	homodimer interface [polypeptide binding]; other site
1170562006080	catalytic residue [active]
1170562006081	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562006082	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562006083	active site
1170562006084	phosphorylation site [posttranslational modification]
1170562006085	intermolecular recognition site; other site
1170562006086	dimerization interface [polypeptide binding]; other site
1170562006087	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
1170562006088	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1170562006089	GIY-YIG motif/motif A; other site
1170562006090	active site
1170562006091	catalytic site [active]
1170562006092	putative DNA binding site [nucleotide binding]; other site
1170562006093	metal binding site [ion binding]; metal-binding site
1170562006094	UvrB/uvrC motif; Region: UVR; pfam02151
1170562006095	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
1170562006096	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859
1170562006097	Ribosome inactivating protein; Region: RIP; pfam00161
1170562006098	WD40 repeats; Region: WD40; smart00320
1170562006099	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
1170562006100	structural tetrad; other site
1170562006101	FOG: WD40 repeat [General function prediction only]; Region: COG2319
1170562006102	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
1170562006103	structural tetrad; other site
1170562006104	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
1170562006105	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
1170562006106	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
1170562006107	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
1170562006108	beta-phosphoglucomutase; Region: bPGM; TIGR01990
1170562006109	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1170562006110	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1170562006111	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
1170562006112	sucrose synthase; Region: sucr_synth; TIGR02470
1170562006113	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
1170562006114	putative ADP-binding pocket [chemical binding]; other site
1170562006115	Protein of unknown function (DUF3122); Region: DUF3122; pfam11320
1170562006116	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
1170562006117	Chain length determinant protein; Region: Wzz; cl15801
1170562006118	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
1170562006119	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1170562006120	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
1170562006121	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
1170562006122	NAD binding site [chemical binding]; other site
1170562006123	substrate binding site [chemical binding]; other site
1170562006124	homodimer interface [polypeptide binding]; other site
1170562006125	active site
1170562006126	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
1170562006127	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
1170562006128	substrate binding site; other site
1170562006129	tetramer interface; other site
1170562006130	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221
1170562006131	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
1170562006132	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
1170562006133	NADP binding site [chemical binding]; other site
1170562006134	active site
1170562006135	putative substrate binding site [chemical binding]; other site
1170562006136	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1170562006137	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1170562006138	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_7; cd05844
1170562006139	putative ADP-binding pocket [chemical binding]; other site
1170562006140	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1170562006141	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1170562006142	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1170562006143	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1170562006144	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1170562006145	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1170562006146	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1170562006147	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1170562006148	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1170562006149	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
1170562006150	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1170562006151	This family is most closely related to the GT1 family of glycosyltransferases. wcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis; Region: GT1_wcfI_like; cd03825
1170562006152	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
1170562006153	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1170562006154	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1170562006155	Walker A/P-loop; other site
1170562006156	ATP binding site [chemical binding]; other site
1170562006157	Q-loop/lid; other site
1170562006158	ABC transporter signature motif; other site
1170562006159	Walker B; other site
1170562006160	D-loop; other site
1170562006161	H-loop/switch region; other site
1170562006162	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
1170562006163	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1170562006164	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1170562006165	BON domain; Region: BON; pfam04972
1170562006166	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
1170562006167	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
1170562006168	CoA-binding site [chemical binding]; other site
1170562006169	ATP-binding [chemical binding]; other site
1170562006170	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
1170562006171	active site
1170562006172	SAM binding site [chemical binding]; other site
1170562006173	homodimer interface [polypeptide binding]; other site
1170562006174	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
1170562006175	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
1170562006176	active site
1170562006177	Domain of unknown function DUF11; Region: DUF11; pfam01345
1170562006178	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1170562006179	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4719
1170562006180	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1170562006181	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562006182	active site
1170562006183	phosphorylation site [posttranslational modification]
1170562006184	intermolecular recognition site; other site
1170562006185	dimerization interface [polypeptide binding]; other site
1170562006186	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562006187	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562006188	active site
1170562006189	phosphorylation site [posttranslational modification]
1170562006190	intermolecular recognition site; other site
1170562006191	dimerization interface [polypeptide binding]; other site
1170562006192	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1170562006193	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562006194	active site
1170562006195	phosphorylation site [posttranslational modification]
1170562006196	intermolecular recognition site; other site
1170562006197	dimerization interface [polypeptide binding]; other site
1170562006198	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
1170562006199	DNA binding site [nucleotide binding]
1170562006200	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562006201	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562006202	active site
1170562006203	phosphorylation site [posttranslational modification]
1170562006204	intermolecular recognition site; other site
1170562006205	dimerization interface [polypeptide binding]; other site
1170562006206	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1170562006207	metal binding site [ion binding]; metal-binding site
1170562006208	active site
1170562006209	I-site; other site
1170562006210	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
1170562006211	DNA protecting protein DprA; Region: dprA; TIGR00732
1170562006212	Domain of unknown function (DUF3596); Region: DUF3596; pfam12167
1170562006213	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
1170562006214	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1170562006215	active site
1170562006216	catalytic residues [active]
1170562006217	DNA binding site [nucleotide binding]
1170562006218	Int/Topo IB signature motif; other site
1170562006219	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1170562006220	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1170562006221	Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093
1170562006222	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1170562006223	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1170562006224	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
1170562006225	A new structural DNA glycosylase; Region: AlkD_like; cd06561
1170562006226	active site
1170562006227	Putative phosphatase (DUF442); Region: DUF442; cl17385
1170562006228	TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325
1170562006229	AAA-like domain; Region: AAA_10; pfam12846
1170562006230	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
1170562006231	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
1170562006232	Transposase [DNA replication, recombination, and repair]; Region: COG5421
1170562006233	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
1170562006234	putative active site [active]
1170562006235	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
1170562006236	ATPase family associated with various cellular activities (AAA); Region: AAA; pfam00004
1170562006237	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
1170562006238	Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277
1170562006239	active site
1170562006240	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
1170562006241	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
1170562006242	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
1170562006243	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1170562006244	Walker A motif; other site
1170562006245	ATP binding site [chemical binding]; other site
1170562006246	Walker B motif; other site
1170562006247	ParB-like nuclease domain; Region: ParBc; cl02129
1170562006248	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
1170562006249	PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595
1170562006250	Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663
1170562006251	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
1170562006252	Mg binding site [ion binding]; other site
1170562006253	nucleotide binding site [chemical binding]; other site
1170562006254	putative protofilament interface [polypeptide binding]; other site
1170562006255	conjugal transfer protein TraL; Provisional; Region: PRK13886
1170562006256	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1170562006257	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562006258	active site
1170562006259	phosphorylation site [posttranslational modification]
1170562006260	intermolecular recognition site; other site
1170562006261	dimerization interface [polypeptide binding]; other site
1170562006262	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1170562006263	DNA binding residues [nucleotide binding]
1170562006264	dimerization interface [polypeptide binding]; other site
1170562006265	Prophage antirepressor [Transcription]; Region: COG3617
1170562006266	BRO family, N-terminal domain; Region: Bro-N; smart01040
1170562006267	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
1170562006268	Fatty acid desaturase; Region: FA_desaturase; pfam00487
1170562006269	putative di-iron ligands [ion binding]; other site
1170562006270	TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
1170562006271	Protein of unknown function (DUF3419); Region: DUF3419; cl15422
1170562006272	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
1170562006273	FOG: WD40 repeat [General function prediction only]; Region: COG2319
1170562006274	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
1170562006275	structural tetrad; other site
1170562006276	FOG: WD40 repeat [General function prediction only]; Region: COG2319
1170562006277	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
1170562006278	structural tetrad; other site
1170562006279	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
1170562006280	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1170562006281	Caspase domain; Region: Peptidase_C14; pfam00656
1170562006282	TPR repeat; Region: TPR_11; pfam13414
1170562006283	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562006284	binding surface
1170562006285	TPR motif; other site
1170562006286	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562006287	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562006288	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562006289	binding surface
1170562006290	TPR motif; other site
1170562006291	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562006292	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562006293	Tetratricopeptide repeat; Region: TPR_10; pfam13374
1170562006294	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562006295	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562006296	binding surface
1170562006297	TPR motif; other site
1170562006298	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562006299	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562006300	binding surface
1170562006301	TPR motif; other site
1170562006302	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562006303	CHAT domain; Region: CHAT; pfam12770
1170562006304	Caspase domain; Region: Peptidase_C14; pfam00656
1170562006305	Domain of unknown function (DUF4384); Region: DUF4384; pfam14326
1170562006306	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562006307	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562006308	binding surface
1170562006309	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562006310	TPR motif; other site
1170562006311	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562006312	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562006313	binding surface
1170562006314	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562006315	TPR motif; other site
1170562006316	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562006317	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562006318	binding surface
1170562006319	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562006320	TPR motif; other site
1170562006321	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562006322	CHAT domain; Region: CHAT; pfam12770
1170562006323	CHAT domain; Region: CHAT; pfam12770
1170562006324	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562006325	binding surface
1170562006326	TPR repeat; Region: TPR_11; pfam13414
1170562006327	TPR motif; other site
1170562006328	TPR repeat; Region: TPR_11; pfam13414
1170562006329	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562006330	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562006331	TPR motif; other site
1170562006332	binding surface
1170562006333	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562006334	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562006335	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562006336	binding surface
1170562006337	TPR motif; other site
1170562006338	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562006339	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562006340	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562006341	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562006342	binding surface
1170562006343	TPR motif; other site
1170562006344	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562006345	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562006346	CHAT domain; Region: CHAT; pfam12770
1170562006347	CHAT domain; Region: CHAT; cl17868
1170562006348	CHASE2 domain; Region: CHASE2; cl01732
1170562006349	CHASE2 domain; Region: CHASE2; cl01732
1170562006350	TPR repeat; Region: TPR_11; pfam13414
1170562006351	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562006352	binding surface
1170562006353	TPR motif; other site
1170562006354	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562006355	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562006356	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562006357	binding surface
1170562006358	TPR motif; other site
1170562006359	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562006360	binding surface
1170562006361	TPR motif; other site
1170562006362	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562006363	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562006364	TPR motif; other site
1170562006365	binding surface
1170562006366	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562006367	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562006368	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562006369	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562006370	binding surface
1170562006371	TPR motif; other site
1170562006372	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562006373	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562006374	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562006375	binding surface
1170562006376	TPR motif; other site
1170562006377	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562006378	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562006379	TPR motif; other site
1170562006380	binding surface
1170562006381	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562006382	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562006383	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1170562006384	TPR motif; other site
1170562006385	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562006386	binding surface
1170562006387	CHAT domain; Region: CHAT; cl17868
1170562006388	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
1170562006389	oligomeric interface; other site
1170562006390	putative active site [active]
1170562006391	homodimer interface [polypeptide binding]; other site
1170562006392	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
1170562006393	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
1170562006394	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
1170562006395	active site
1170562006396	catalytic residues [active]
1170562006397	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
1170562006398	NB-ARC domain; Region: NB-ARC; pfam00931
1170562006399	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562006400	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562006401	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562006402	binding surface
1170562006403	TPR motif; other site
1170562006404	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562006405	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562006406	Tetratricopeptide repeat; Region: TPR_10; pfam13374
1170562006407	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562006408	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562006409	binding surface
1170562006410	TPR motif; other site
1170562006411	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562006412	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
1170562006413	YcfA-like protein; Region: YcfA; pfam07927
1170562006414	NB-ARC domain; Region: NB-ARC; pfam00931
1170562006415	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562006416	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562006417	binding surface
1170562006418	TPR motif; other site
1170562006419	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562006420	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562006421	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562006422	binding surface
1170562006423	TPR motif; other site
1170562006424	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562006425	Helix-turn-helix domain; Region: HTH_28; pfam13518
1170562006426	Winged helix-turn helix; Region: HTH_29; pfam13551
1170562006427	Homeodomain-like domain; Region: HTH_32; pfam13565
1170562006428	DDE superfamily endonuclease; Region: DDE_3; pfam13358
1170562006429	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
1170562006430	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1170562006431	NACHT domain; Region: NACHT; pfam05729
1170562006432	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1170562006433	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
1170562006434	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1170562006435	G1 box; other site
1170562006436	GTP/Mg2+ binding site [chemical binding]; other site
1170562006437	G2 box; other site
1170562006438	Switch I region; other site
1170562006439	G3 box; other site
1170562006440	Switch II region; other site
1170562006441	G4 box; other site
1170562006442	G5 box; other site
1170562006443	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1170562006444	MoxR-like ATPases [General function prediction only]; Region: COG0714
1170562006445	Walker A motif; other site
1170562006446	ATP binding site [chemical binding]; other site
1170562006447	Walker B motif; other site
1170562006448	arginine finger; other site
1170562006449	Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042
1170562006450	MoxR-like ATPases [General function prediction only]; Region: COG0714
1170562006451	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1170562006452	Walker A motif; other site
1170562006453	ATP binding site [chemical binding]; other site
1170562006454	Walker B motif; other site
1170562006455	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825
1170562006456	CHAT domain; Region: CHAT; cl17868
1170562006457	Calcium binding; Region: Calci_bind_CcbP; pfam11535
1170562006458	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
1170562006459	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
1170562006460	PemK-like protein; Region: PemK; pfam02452
1170562006461	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
1170562006462	NACHT domain; Region: NACHT; pfam05729
1170562006463	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562006464	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
1170562006465	structural tetrad; other site
1170562006466	FOG: WD40 repeat [General function prediction only]; Region: COG2319
1170562006467	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
1170562006468	structural tetrad; other site
1170562006469	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
1170562006470	thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356
1170562006471	ATP binding site [chemical binding]; other site
1170562006472	substrate interface [chemical binding]; other site
1170562006473	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1170562006474	gliding motility-associated lipoprotein GldK; Region: GldK_short; TIGR03529
1170562006475	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
1170562006476	Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin...; Region: UBCc; cl00154
1170562006477	Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996
1170562006478	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1170562006479	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1170562006480	Walker A motif; other site
1170562006481	ATP binding site [chemical binding]; other site
1170562006482	Walker B motif; other site
1170562006483	arginine finger; other site
1170562006484	Uncharacterized conserved protein [Function unknown]; Region: COG1262
1170562006485	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
1170562006486	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1170562006487	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1170562006488	Walker A motif; other site
1170562006489	ATP binding site [chemical binding]; other site
1170562006490	Walker B motif; other site
1170562006491	arginine finger; other site
1170562006492	gliding motility-associated lipoprotein GldK; Region: GldK_short; TIGR03529
1170562006493	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
1170562006494	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562006495	gliding motility-associated lipoprotein GldK; Region: GldK_short; TIGR03529
1170562006496	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
1170562006497	Clp amino terminal domain; Region: Clp_N; pfam02861
1170562006498	Clp amino terminal domain; Region: Clp_N; pfam02861
1170562006499	AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337
1170562006500	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1170562006501	FeS/SAM binding site; other site
1170562006502	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
1170562006503	active site
1170562006504	metal binding site [ion binding]; metal-binding site
1170562006505	interdomain interaction site; other site
1170562006506	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1170562006507	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1170562006508	non-specific DNA binding site [nucleotide binding]; other site
1170562006509	salt bridge; other site
1170562006510	sequence-specific DNA binding site [nucleotide binding]; other site
1170562006511	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1170562006512	putative active site [active]
1170562006513	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
1170562006514	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
1170562006515	cofactor binding site; other site
1170562006516	DNA binding site [nucleotide binding]
1170562006517	substrate interaction site [chemical binding]; other site
1170562006518	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
1170562006519	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
1170562006520	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
1170562006521	putative active site [active]
1170562006522	XisI protein; Region: XisI; pfam08869
1170562006523	XisH protein; Region: XisH; pfam08814
1170562006524	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
1170562006525	SNF2 Helicase protein; Region: DUF3670; pfam12419
1170562006526	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1170562006527	ATP binding site [chemical binding]; other site
1170562006528	putative Mg++ binding site [ion binding]; other site
1170562006529	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1170562006530	nucleotide binding region [chemical binding]; other site
1170562006531	ATP-binding site [chemical binding]; other site
1170562006532	Uncharacterized conserved protein [Function unknown]; Region: COG4279
1170562006533	SWIM zinc finger; Region: SWIM; pfam04434
1170562006534	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1170562006535	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1170562006536	Coenzyme A binding pocket [chemical binding]; other site
1170562006537	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1170562006538	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1170562006539	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1170562006540	Coenzyme A binding pocket [chemical binding]; other site
1170562006541	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
1170562006542	active site
1170562006543	NTP binding site [chemical binding]; other site
1170562006544	metal binding triad [ion binding]; metal-binding site
1170562006545	antibiotic binding site [chemical binding]; other site
1170562006546	AAA domain; Region: AAA_33; pfam13671
1170562006547	AAA domain; Region: AAA_17; pfam13207
1170562006548	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
1170562006549	oligomeric interface; other site
1170562006550	putative active site [active]
1170562006551	homodimer interface [polypeptide binding]; other site
1170562006552	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
1170562006553	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1170562006554	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
1170562006555	P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923
1170562006556	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
1170562006557	HsdM N-terminal domain; Region: HsdM_N; pfam12161
1170562006558	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1170562006559	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
1170562006560	HsdM N-terminal domain; Region: HsdM_N; pfam12161
1170562006561	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1170562006562	Homeodomain-like domain; Region: HTH_23; pfam13384
1170562006563	Winged helix-turn helix; Region: HTH_29; pfam13551
1170562006564	Homeodomain-like domain; Region: HTH_32; pfam13565
1170562006565	DDE superfamily endonuclease; Region: DDE_3; pfam13358
1170562006566	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
1170562006567	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
1170562006568	active site
1170562006569	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
1170562006570	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1170562006571	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
1170562006572	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1170562006573	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
1170562006574	Prostaglandin dehydrogenases; Region: PGDH; cd05288
1170562006575	NAD(P) binding site [chemical binding]; other site
1170562006576	substrate binding site [chemical binding]; other site
1170562006577	dimer interface [polypeptide binding]; other site
1170562006578	myosin-cross-reactive antigen; Provisional; Region: PRK13977
1170562006579	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287
1170562006580	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1170562006581	catalytic Zn binding site [ion binding]; other site
1170562006582	NAD(P) binding site [chemical binding]; other site
1170562006583	structural Zn binding site [ion binding]; other site
1170562006584	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
1170562006585	BON domain; Region: BON; pfam04972
1170562006586	BON domain; Region: BON; pfam04972
1170562006587	S-layer homology domain; Region: SLH; pfam00395
1170562006588	S-layer homology domain; Region: SLH; pfam00395
1170562006589	Protein of unknown function (DUF3370); Region: DUF3370; pfam11850
1170562006590	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
1170562006591	putative active site [active]
1170562006592	Tetratricopeptide repeat; Region: TPR_1; pfam00515
1170562006593	FOG: WD40 repeat [General function prediction only]; Region: COG2319
1170562006594	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
1170562006595	structural tetrad; other site
1170562006596	Cache domain; Region: Cache_1; pfam02743
1170562006597	HAMP domain; Region: HAMP; pfam00672
1170562006598	dimerization interface [polypeptide binding]; other site
1170562006599	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
1170562006600	HAMP domain; Region: HAMP; pfam00672
1170562006601	phage tail protein domain; Region: tail_TIGR02242
1170562006602	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
1170562006603	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
1170562006604	four helix bundle protein; Region: TIGR02436
1170562006605	Gene 25-like lysozyme; Region: GPW_gp25; pfam04965
1170562006606	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
1170562006607	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
1170562006608	Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862
1170562006609	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1170562006610	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1170562006611	Walker A motif; other site
1170562006612	ATP binding site [chemical binding]; other site
1170562006613	Walker B motif; other site
1170562006614	arginine finger; other site
1170562006615	Protein of unknown function (DUF4255); Region: DUF4255; pfam14065
1170562006616	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
1170562006617	Phage tail sheath protein FI [General function prediction only]; Region: COG3497
1170562006618	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl17313
1170562006619	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841
1170562006620	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841
1170562006621	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl17313
1170562006622	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
1170562006623	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
1170562006624	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733
1170562006625	Domain of unknown function (DUF4280); Region: DUF4280; pfam14107
1170562006626	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
1170562006627	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1170562006628	active site
1170562006629	ATP binding site [chemical binding]; other site
1170562006630	substrate binding site [chemical binding]; other site
1170562006631	PBP superfamily domain; Region: PBP_like_2; pfam12849
1170562006632	TPR repeat; Region: TPR_11; pfam13414
1170562006633	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562006634	binding surface
1170562006635	TPR motif; other site
1170562006636	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
1170562006637	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562006638	binding surface
1170562006639	TPR motif; other site
1170562006640	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
1170562006641	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562006642	binding surface
1170562006643	TPR motif; other site
1170562006644	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562006645	binding surface
1170562006646	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1170562006647	TPR motif; other site
1170562006648	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1170562006649	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562006650	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562006651	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1170562006652	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562006653	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
1170562006654	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562006655	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562006656	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562006657	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562006658	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562006659	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562006660	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1170562006661	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1170562006662	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
1170562006663	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1170562006664	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
1170562006665	acyl-activating enzyme (AAE) consensus motif; other site
1170562006666	putative AMP binding site [chemical binding]; other site
1170562006667	putative active site [active]
1170562006668	putative CoA binding site [chemical binding]; other site
1170562006669	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
1170562006670	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1170562006671	putative substrate translocation pore; other site
1170562006672	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1170562006673	Putative phosphatase (DUF442); Region: DUF442; cl17385
1170562006674	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
1170562006675	A new structural DNA glycosylase; Region: AlkD_like; cd06561
1170562006676	active site
1170562006677	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1170562006678	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1170562006679	ligand binding site [chemical binding]; other site
1170562006680	flexible hinge region; other site
1170562006681	Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967
1170562006682	classical (c) SDR, subgroup 2; Region: SDR_c2; cd05370
1170562006683	putative NAD(P) binding site [chemical binding]; other site
1170562006684	active site
1170562006685	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
1170562006686	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
1170562006687	homodimer interface [polypeptide binding]; other site
1170562006688	active site
1170562006689	TDP-binding site; other site
1170562006690	acceptor substrate-binding pocket; other site
1170562006691	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1170562006692	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1170562006693	Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093
1170562006694	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1170562006695	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1170562006696	Domain of unknown function (DUF4277); Region: DUF4277; pfam14104
1170562006697	Transposase [DNA replication, recombination, and repair]; Region: COG5421
1170562006698	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
1170562006699	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1170562006700	non-specific DNA binding site [nucleotide binding]; other site
1170562006701	salt bridge; other site
1170562006702	sequence-specific DNA binding site [nucleotide binding]; other site
1170562006703	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1170562006704	Uncharacterized conserved protein [Function unknown]; Region: COG4715
1170562006705	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
1170562006706	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
1170562006707	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
1170562006708	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1170562006709	ATP binding site [chemical binding]; other site
1170562006710	putative Mg++ binding site [ion binding]; other site
1170562006711	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1170562006712	nucleotide binding region [chemical binding]; other site
1170562006713	ATP-binding site [chemical binding]; other site
1170562006714	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
1170562006715	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1170562006716	The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes.  But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736
1170562006717	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1170562006718	catalytic residue [active]
1170562006719	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
1170562006720	ThiS-like ubiquitin; Region: ThiS-like; pfam14453
1170562006721	Prokaryotic E2 family E; Region: Prok-E2_E; pfam14462
1170562006722	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476
1170562006723	ThiF family; Region: ThiF; pfam00899
1170562006724	ATP binding site [chemical binding]; other site
1170562006725	Peptidase family M48; Region: Peptidase_M48; cl12018
1170562006726	DDE superfamily endonuclease; Region: DDE_3; pfam13358
1170562006727	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
1170562006728	Homeodomain-like domain; Region: HTH_23; pfam13384
1170562006729	Winged helix-turn helix; Region: HTH_29; pfam13551
1170562006730	Homeodomain-like domain; Region: HTH_32; pfam13565
1170562006731	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
1170562006732	HEAT repeat; Region: HEAT; pfam02985
1170562006733	HEAT repeats; Region: HEAT_2; pfam13646
1170562006734	HEAT repeats; Region: HEAT_2; pfam13646
1170562006735	HEAT repeats; Region: HEAT_2; pfam13646
1170562006736	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
1170562006737	HEAT repeats; Region: HEAT_2; pfam13646
1170562006738	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
1170562006739	Caspase domain; Region: Peptidase_C14; pfam00656
1170562006740	AAA domain; Region: AAA_33; pfam13671
1170562006741	AAA domain; Region: AAA_17; pfam13207
1170562006742	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
1170562006743	active site
1170562006744	NTP binding site [chemical binding]; other site
1170562006745	metal binding triad [ion binding]; metal-binding site
1170562006746	antibiotic binding site [chemical binding]; other site
1170562006747	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1170562006748	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1170562006749	Coenzyme A binding pocket [chemical binding]; other site
1170562006750	Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787
1170562006751	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1170562006752	Walker A motif; other site
1170562006753	ATP binding site [chemical binding]; other site
1170562006754	Caspase domain; Region: Peptidase_C14; pfam00656
1170562006755	Caspase domain; Region: Peptidase_C14; pfam00656
1170562006756	TPR repeat; Region: TPR_11; pfam13414
1170562006757	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562006758	binding surface
1170562006759	TPR motif; other site
1170562006760	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1170562006761	TPR repeat; Region: TPR_11; pfam13414
1170562006762	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562006763	binding surface
1170562006764	TPR motif; other site
1170562006765	CHAT domain; Region: CHAT; cl17868
1170562006766	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
1170562006767	ParG; Region: ParG; pfam09274
1170562006768	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
1170562006769	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
1170562006770	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
1170562006771	TPR repeat; Region: TPR_11; pfam13414
1170562006772	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562006773	binding surface
1170562006774	TPR motif; other site
1170562006775	type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897
1170562006776	LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792
1170562006777	active site
1170562006778	zinc binding site [ion binding]; other site
1170562006779	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1170562006780	Phosphotransferase enzyme family; Region: APH; pfam01636
1170562006781	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
1170562006782	FOG: WD40 repeat [General function prediction only]; Region: COG2319
1170562006783	structural tetrad; other site
1170562006784	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
1170562006785	putative catalytic site [active]
1170562006786	putative metal binding site [ion binding]; other site
1170562006787	putative phosphate binding site [ion binding]; other site
1170562006788	FOG: WD40 repeat [General function prediction only]; Region: COG2319
1170562006789	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
1170562006790	structural tetrad; other site
1170562006791	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
1170562006792	CHAT domain; Region: CHAT; cl17868
1170562006793	CHASE2 domain; Region: CHASE2; pfam05226
1170562006794	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
1170562006795	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562006796	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562006797	binding surface
1170562006798	TPR motif; other site
1170562006799	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562006800	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562006801	binding surface
1170562006802	TPR motif; other site
1170562006803	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562006804	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562006805	binding surface
1170562006806	TPR motif; other site
1170562006807	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562006808	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562006809	Tetratricopeptide repeat; Region: TPR_1; pfam00515
1170562006810	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562006811	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562006812	binding surface
1170562006813	TPR motif; other site
1170562006814	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562006815	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562006816	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562006817	binding surface
1170562006818	TPR motif; other site
1170562006819	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562006820	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562006821	CHAT domain; Region: CHAT; cl17868
1170562006822	CHAT domain; Region: CHAT; pfam12770
1170562006823	Caspase domain; Region: Peptidase_C14; pfam00656
1170562006824	Domain of unknown function (DUF4384); Region: DUF4384; pfam14326
1170562006825	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
1170562006826	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
1170562006827	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1170562006828	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
1170562006829	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1170562006830	HlyD family secretion protein; Region: HlyD_3; pfam13437
1170562006831	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1170562006832	ligand binding site [chemical binding]; other site
1170562006833	flexible hinge region; other site
1170562006834	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
1170562006835	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
1170562006836	putative active site [active]
1170562006837	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1170562006838	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1170562006839	Walker A/P-loop; other site
1170562006840	ATP binding site [chemical binding]; other site
1170562006841	Q-loop/lid; other site
1170562006842	ABC transporter signature motif; other site
1170562006843	Walker B; other site
1170562006844	D-loop; other site
1170562006845	H-loop/switch region; other site
1170562006846	Homeodomain-like domain; Region: HTH_23; pfam13384
1170562006847	Winged helix-turn helix; Region: HTH_29; pfam13551
1170562006848	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
1170562006849	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
1170562006850	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1170562006851	non-specific DNA binding site [nucleotide binding]; other site
1170562006852	salt bridge; other site
1170562006853	sequence-specific DNA binding site [nucleotide binding]; other site
1170562006854	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
1170562006855	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1170562006856	catalytic loop [active]
1170562006857	iron binding site [ion binding]; other site
1170562006858	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1170562006859	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
1170562006860	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
1170562006861	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
1170562006862	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
1170562006863	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1170562006864	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
1170562006865	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1170562006866	hypothetical protein; Provisional; Region: PRK07236
1170562006867	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
1170562006868	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
1170562006869	XdhC Rossmann domain; Region: XdhC_C; pfam13478
1170562006870	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
1170562006871	Ligand binding site; other site
1170562006872	metal-binding site
1170562006873	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
1170562006874	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1170562006875	The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes.  But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736
1170562006876	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1170562006877	catalytic residue [active]
1170562006878	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1170562006879	Peptidase family M23; Region: Peptidase_M23; pfam01551
1170562006880	Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525
1170562006881	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1170562006882	active site
1170562006883	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
1170562006884	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
1170562006885	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
1170562006886	cofactor binding site; other site
1170562006887	DNA binding site [nucleotide binding]
1170562006888	substrate interaction site [chemical binding]; other site
1170562006889	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
1170562006890	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1170562006891	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1170562006892	metal-binding site [ion binding]
1170562006893	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1170562006894	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1170562006895	Plastocyanin domain containing protein [General function prediction only]; Region: COG4633
1170562006896	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
1170562006897	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1170562006898	S-adenosylmethionine binding site [chemical binding]; other site
1170562006899	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
1170562006900	DNA binding residues [nucleotide binding]
1170562006901	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
1170562006902	dimer interface [polypeptide binding]; other site
1170562006903	metal binding site [ion binding]; metal-binding site
1170562006904	Predicted membrane protein [Function unknown]; Region: COG2149
1170562006905	H+ Antiporter protein; Region: 2A0121; TIGR00900
1170562006906	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1170562006907	putative substrate translocation pore; other site
1170562006908	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
1170562006909	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1170562006910	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
1170562006911	HlyD family secretion protein; Region: HlyD_3; pfam13437
1170562006912	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1170562006913	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1170562006914	S-adenosylmethionine binding site [chemical binding]; other site
1170562006915	Domain of unknown function (DUF305); Region: DUF305; pfam03713
1170562006916	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1170562006917	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562006918	active site
1170562006919	phosphorylation site [posttranslational modification]
1170562006920	intermolecular recognition site; other site
1170562006921	dimerization interface [polypeptide binding]; other site
1170562006922	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1170562006923	DNA binding site [nucleotide binding]
1170562006924	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
1170562006925	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562006926	dimer interface [polypeptide binding]; other site
1170562006927	phosphorylation site [posttranslational modification]
1170562006928	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562006929	ATP binding site [chemical binding]; other site
1170562006930	Mg2+ binding site [ion binding]; other site
1170562006931	G-X-G motif; other site
1170562006932	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1170562006933	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562006934	active site
1170562006935	phosphorylation site [posttranslational modification]
1170562006936	intermolecular recognition site; other site
1170562006937	dimerization interface [polypeptide binding]; other site
1170562006938	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1170562006939	DNA binding site [nucleotide binding]
1170562006940	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
1170562006941	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1170562006942	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1170562006943	siderophore binding site; other site
1170562006944	TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062
1170562006945	putative dimer interface [polypeptide binding]; other site
1170562006946	putative [2Fe-2S] cluster binding site [ion binding]; other site
1170562006947	H+ Antiporter protein; Region: 2A0121; TIGR00900
1170562006948	AMIN domain; Region: AMIN; pfam11741
1170562006949	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
1170562006950	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1170562006951	N-terminal plug; other site
1170562006952	ligand-binding site [chemical binding]; other site
1170562006953	acyl-CoA synthetase; Validated; Region: PRK05850
1170562006954	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
1170562006955	acyl-activating enzyme (AAE) consensus motif; other site
1170562006956	active site
1170562006957	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1170562006958	Condensation domain; Region: Condensation; pfam00668
1170562006959	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1170562006960	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1170562006961	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1170562006962	acyl-activating enzyme (AAE) consensus motif; other site
1170562006963	AMP binding site [chemical binding]; other site
1170562006964	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1170562006965	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
1170562006966	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1170562006967	active site
1170562006968	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1170562006969	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
1170562006970	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
1170562006971	putative NADP binding site [chemical binding]; other site
1170562006972	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
1170562006973	active site
1170562006974	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1170562006975	Condensation domain; Region: Condensation; pfam00668
1170562006976	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1170562006977	diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264
1170562006978	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1170562006979	inhibitor-cofactor binding pocket; inhibition site
1170562006980	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1170562006981	catalytic residue [active]
1170562006982	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1170562006983	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1170562006984	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1170562006985	acyl-activating enzyme (AAE) consensus motif; other site
1170562006986	AMP binding site [chemical binding]; other site
1170562006987	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1170562006988	Condensation domain; Region: Condensation; pfam00668
1170562006989	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1170562006990	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1170562006991	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1170562006992	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1170562006993	acyl-activating enzyme (AAE) consensus motif; other site
1170562006994	AMP binding site [chemical binding]; other site
1170562006995	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1170562006996	Condensation domain; Region: Condensation; pfam00668
1170562006997	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1170562006998	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1170562006999	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1170562007000	acyl-activating enzyme (AAE) consensus motif; other site
1170562007001	AMP binding site [chemical binding]; other site
1170562007002	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1170562007003	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1170562007004	S-adenosylmethionine binding site [chemical binding]; other site
1170562007005	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1170562007006	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1170562007007	Condensation domain; Region: Condensation; pfam00668
1170562007008	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1170562007009	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1170562007010	Condensation domain; Region: Condensation; pfam00668
1170562007011	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1170562007012	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1170562007013	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1170562007014	acyl-activating enzyme (AAE) consensus motif; other site
1170562007015	AMP binding site [chemical binding]; other site
1170562007016	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1170562007017	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1170562007018	S-adenosylmethionine binding site [chemical binding]; other site
1170562007019	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1170562007020	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1170562007021	Condensation domain; Region: Condensation; pfam00668
1170562007022	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1170562007023	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1170562007024	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
1170562007025	Condensation domain; Region: Condensation; pfam00668
1170562007026	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1170562007027	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1170562007028	acyl-activating enzyme (AAE) consensus motif; other site
1170562007029	AMP binding site [chemical binding]; other site
1170562007030	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1170562007031	Condensation domain; Region: Condensation; pfam00668
1170562007032	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1170562007033	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1170562007034	The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116
1170562007035	acyl-activating enzyme (AAE) consensus motif; other site
1170562007036	AMP binding site [chemical binding]; other site
1170562007037	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1170562007038	Condensation domain; Region: Condensation; pfam00668
1170562007039	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1170562007040	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1170562007041	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
1170562007042	Condensation domain; Region: Condensation; pfam00668
1170562007043	L-aminoadipate-semialdehyde dehydrogenase; Region: alpha_am_amid; TIGR03443
1170562007044	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1170562007045	acyl-activating enzyme (AAE) consensus motif; other site
1170562007046	AMP binding site [chemical binding]; other site
1170562007047	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1170562007048	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
1170562007049	putative NAD(P) binding site [chemical binding]; other site
1170562007050	active site
1170562007051	putative substrate binding site [chemical binding]; other site
1170562007052	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
1170562007053	Penicillin amidase; Region: Penicil_amidase; pfam01804
1170562007054	Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936
1170562007055	active site
1170562007056	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
1170562007057	Predicted membrane protein [Function unknown]; Region: COG2510
1170562007058	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1170562007059	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1170562007060	Walker A/P-loop; other site
1170562007061	ATP binding site [chemical binding]; other site
1170562007062	Q-loop/lid; other site
1170562007063	ABC transporter signature motif; other site
1170562007064	Walker B; other site
1170562007065	D-loop; other site
1170562007066	H-loop/switch region; other site
1170562007067	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1170562007068	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1170562007069	ABC-ATPase subunit  interface; other site
1170562007070	dimer interface [polypeptide binding]; other site
1170562007071	putative PBP binding regions; other site
1170562007072	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1170562007073	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1170562007074	ABC-ATPase subunit  interface; other site
1170562007075	dimer interface [polypeptide binding]; other site
1170562007076	putative PBP binding regions; other site
1170562007077	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
1170562007078	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1170562007079	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1170562007080	AAA-like domain; Region: AAA_10; pfam12846
1170562007081	replicative DNA helicase; Region: DnaB; TIGR00665
1170562007082	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1170562007083	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1170562007084	Walker A motif; other site
1170562007085	ATP binding site [chemical binding]; other site
1170562007086	Walker B motif; other site
1170562007087	DNA binding loops [nucleotide binding]
1170562007088	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1170562007089	putative Zn2+ binding site [ion binding]; other site
1170562007090	putative DNA binding site [nucleotide binding]; other site
1170562007091	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1170562007092	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1170562007093	Coenzyme A binding pocket [chemical binding]; other site
1170562007094	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1170562007095	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
1170562007096	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1170562007097	active site
1170562007098	catalytic residues [active]
1170562007099	DNA binding site [nucleotide binding]
1170562007100	Int/Topo IB signature motif; other site
1170562007101	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1170562007102	active site
1170562007103	catalytic residues [active]
1170562007104	DNA binding site [nucleotide binding]
1170562007105	Int/Topo IB signature motif; other site
1170562007106	Stress up-regulated Nod 19; Region: SURNod19; pfam07712
1170562007107	Homeodomain-like domain; Region: HTH_23; cl17451
1170562007108	KGK domain; Region: KGK; pfam08872
1170562007109	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1170562007110	AAA domain; Region: AAA_25; pfam13481
1170562007111	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1170562007112	Walker A motif; other site
1170562007113	ATP binding site [chemical binding]; other site
1170562007114	Walker B motif; other site
1170562007115	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1170562007116	putative DNA binding site [nucleotide binding]; other site
1170562007117	putative Zn2+ binding site [ion binding]; other site
1170562007118	chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349
1170562007119	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1170562007120	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1170562007121	active site
1170562007122	metal binding site [ion binding]; metal-binding site
1170562007123	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1170562007124	Coenzyme A binding pocket [chemical binding]; other site
1170562007125	bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625
1170562007126	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
1170562007127	active site
1170562007128	metal binding site [ion binding]; metal-binding site
1170562007129	KWG Leptospira; Region: KWG; pfam07656
1170562007130	KWG Leptospira; Region: KWG; pfam07656
1170562007131	KWG Leptospira; Region: KWG; pfam07656
1170562007132	KWG Leptospira; Region: KWG; pfam07656
1170562007133	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747
1170562007134	translocation protein TolB; Provisional; Region: tolB; PRK04922
1170562007135	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
1170562007136	Protein of unknown function (DUF2809); Region: DUF2809; pfam10990
1170562007137	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
1170562007138	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1170562007139	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1170562007140	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
1170562007141	Uncharacterized conserved protein [Function unknown]; Region: COG4715
1170562007142	SWIM zinc finger; Region: SWIM; pfam04434
1170562007143	AAA-like domain; Region: AAA_10; pfam12846
1170562007144	AAA-like domain; Region: AAA_10; pfam12846
1170562007145	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
1170562007146	26S proteasome subunit P45 family; Region: 26Sp45; TIGR01242
1170562007147	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1170562007148	Walker A motif; other site
1170562007149	ATP binding site [chemical binding]; other site
1170562007150	Walker B motif; other site
1170562007151	arginine finger; other site
1170562007152	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
1170562007153	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1170562007154	active site
1170562007155	Caspase domain; Region: Peptidase_C14; pfam00656
1170562007156	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1170562007157	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1170562007158	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
1170562007159	Plasmid recombination enzyme; Region: Mob_Pre; pfam01076
1170562007160	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
1170562007161	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
1170562007162	Mg binding site [ion binding]; other site
1170562007163	nucleotide binding site [chemical binding]; other site
1170562007164	putative protofilament interface [polypeptide binding]; other site
1170562007165	conjugal transfer protein TraL; Provisional; Region: PRK13886
1170562007166	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1170562007167	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1170562007168	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562007169	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562007170	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1170562007171	putative DNA binding site [nucleotide binding]; other site
1170562007172	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1170562007173	Coenzyme A binding pocket [chemical binding]; other site
1170562007174	CHAT domain; Region: CHAT; cl17868
1170562007175	AAA ATPase domain; Region: AAA_16; pfam13191
1170562007176	FOG: WD40 repeat [General function prediction only]; Region: COG2319
1170562007177	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
1170562007178	structural tetrad; other site
1170562007179	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
1170562007180	CHAT domain; Region: CHAT; cl17868
1170562007181	FOG: WD40 repeat [General function prediction only]; Region: COG2319
1170562007182	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
1170562007183	structural tetrad; other site
1170562007184	FOG: WD40 repeat [General function prediction only]; Region: COG2319
1170562007185	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
1170562007186	structural tetrad; other site
1170562007187	WD40 repeats; Region: WD40; smart00320
1170562007188	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
1170562007189	RDD family; Region: RDD; pfam06271
1170562007190	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
1170562007191	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1170562007192	non-specific DNA binding site [nucleotide binding]; other site
1170562007193	salt bridge; other site
1170562007194	sequence-specific DNA binding site [nucleotide binding]; other site
1170562007195	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
1170562007196	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
1170562007197	DNA binding residues [nucleotide binding]
1170562007198	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1170562007199	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1170562007200	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
1170562007201	Circadian oscillating protein COP23; Region: COP23; pfam14218
1170562007202	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
1170562007203	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1170562007204	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
1170562007205	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1170562007206	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562007207	binding surface
1170562007208	TPR repeat; Region: TPR_11; pfam13414
1170562007209	TPR motif; other site
1170562007210	TPR repeat; Region: TPR_11; pfam13414
1170562007211	TPR repeat; Region: TPR_11; pfam13414
1170562007212	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562007213	binding surface
1170562007214	TPR motif; other site
1170562007215	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
1170562007216	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562007217	binding surface
1170562007218	TPR motif; other site
1170562007219	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562007220	binding surface
1170562007221	TPR motif; other site
1170562007222	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562007223	binding surface
1170562007224	TPR motif; other site
1170562007225	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562007226	TPR motif; other site
1170562007227	binding surface
1170562007228	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562007229	binding surface
1170562007230	TPR motif; other site
1170562007231	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562007232	binding surface
1170562007233	TPR motif; other site
1170562007234	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562007235	binding surface
1170562007236	TPR motif; other site
1170562007237	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562007238	binding surface
1170562007239	TPR motif; other site
1170562007240	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562007241	binding surface
1170562007242	TPR motif; other site
1170562007243	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562007244	binding surface
1170562007245	TPR motif; other site
1170562007246	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562007247	binding surface
1170562007248	TPR motif; other site
1170562007249	TPR repeat; Region: TPR_11; pfam13414
1170562007250	FOG: WD40 repeat [General function prediction only]; Region: COG2319
1170562007251	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
1170562007252	structural tetrad; other site
1170562007253	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
1170562007254	structural tetrad; other site
1170562007255	FOG: WD40 repeat [General function prediction only]; Region: COG2319
1170562007256	WD40 repeats; Region: WD40; smart00320
1170562007257	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1170562007258	putative active site [active]
1170562007259	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
1170562007260	four helix bundle protein; Region: TIGR02436
1170562007261	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
1170562007262	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
1170562007263	cofactor binding site; other site
1170562007264	DNA binding site [nucleotide binding]
1170562007265	substrate interaction site [chemical binding]; other site
1170562007266	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
1170562007267	type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348
1170562007268	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
1170562007269	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1170562007270	ATP binding site [chemical binding]; other site
1170562007271	putative Mg++ binding site [ion binding]; other site
1170562007272	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1170562007273	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
1170562007274	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1170562007275	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1170562007276	non-specific DNA binding site [nucleotide binding]; other site
1170562007277	salt bridge; other site
1170562007278	sequence-specific DNA binding site [nucleotide binding]; other site
1170562007279	Domain of unknown function (DUF955); Region: DUF955; pfam06114
1170562007280	DDE superfamily endonuclease; Region: DDE_3; pfam13358
1170562007281	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
1170562007282	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1170562007283	Ligand Binding Site [chemical binding]; other site
1170562007284	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1170562007285	Ligand Binding Site [chemical binding]; other site
1170562007286	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
1170562007287	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562007288	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562007289	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562007290	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1170562007291	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562007292	Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276
1170562007293	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
1170562007294	active site
1170562007295	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
1170562007296	active site
1170562007297	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
1170562007298	magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517
1170562007299	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
1170562007300	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1170562007301	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
1170562007302	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1170562007303	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1170562007304	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
1170562007305	dimer interface [polypeptide binding]; other site
1170562007306	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
1170562007307	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
1170562007308	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
1170562007309	chaperone protein DnaJ; Provisional; Region: PRK14299
1170562007310	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1170562007311	HSP70 interaction site [polypeptide binding]; other site
1170562007312	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1170562007313	substrate binding site [polypeptide binding]; other site
1170562007314	dimer interface [polypeptide binding]; other site
1170562007315	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1170562007316	DNA binding residues [nucleotide binding]
1170562007317	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
1170562007318	Ion channel; Region: Ion_trans_2; pfam07885
1170562007319	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1170562007320	YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477
1170562007321	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
1170562007322	[2Fe-2S] cluster binding site [ion binding]; other site
1170562007323	oxidoreductase, 2OG-Fe(II) oxygenase family protein; Region: PLN02984
1170562007324	Protein of unknown function (DUF3891); Region: DUF3891; pfam13030
1170562007325	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
1170562007326	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1170562007327	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
1170562007328	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1170562007329	HlyD family secretion protein; Region: HlyD_3; pfam13437
1170562007330	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1170562007331	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1170562007332	Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
1170562007333	Domain of unknown function (DUF1772); Region: DUF1772; cl12097
1170562007334	CAAX protease self-immunity; Region: Abi; pfam02517
1170562007335	Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876
1170562007336	PspC domain; Region: PspC; pfam04024
1170562007337	Uncharacterized conserved protein [Function unknown]; Region: COG2442
1170562007338	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
1170562007339	Uncharacterized conserved protein [Function unknown]; Region: COG2442
1170562007340	AAA ATPase domain; Region: AAA_15; pfam13175
1170562007341	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1170562007342	Walker A/P-loop; other site
1170562007343	ATP binding site [chemical binding]; other site
1170562007344	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
1170562007345	ABC transporter signature motif; other site
1170562007346	Walker B; other site
1170562007347	D-loop; other site
1170562007348	H-loop/switch region; other site
1170562007349	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1170562007350	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
1170562007351	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1170562007352	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1170562007353	Walker A/P-loop; other site
1170562007354	ATP binding site [chemical binding]; other site
1170562007355	Q-loop/lid; other site
1170562007356	ABC transporter signature motif; other site
1170562007357	Walker B; other site
1170562007358	D-loop; other site
1170562007359	H-loop/switch region; other site
1170562007360	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1170562007361	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1170562007362	Walker A/P-loop; other site
1170562007363	ATP binding site [chemical binding]; other site
1170562007364	Q-loop/lid; other site
1170562007365	ABC transporter signature motif; other site
1170562007366	Walker B; other site
1170562007367	D-loop; other site
1170562007368	H-loop/switch region; other site
1170562007369	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1170562007370	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1170562007371	ligand binding site [chemical binding]; other site
1170562007372	flexible hinge region; other site
1170562007373	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
1170562007374	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1170562007375	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1170562007376	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
1170562007377	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1170562007378	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1170562007379	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
1170562007380	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1170562007381	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562007382	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562007383	active site
1170562007384	phosphorylation site [posttranslational modification]
1170562007385	intermolecular recognition site; other site
1170562007386	dimerization interface [polypeptide binding]; other site
1170562007387	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1170562007388	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562007389	active site
1170562007390	phosphorylation site [posttranslational modification]
1170562007391	intermolecular recognition site; other site
1170562007392	dimerization interface [polypeptide binding]; other site
1170562007393	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1170562007394	DNA binding site [nucleotide binding]
1170562007395	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1170562007396	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1170562007397	dimerization interface [polypeptide binding]; other site
1170562007398	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562007399	dimer interface [polypeptide binding]; other site
1170562007400	phosphorylation site [posttranslational modification]
1170562007401	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562007402	ATP binding site [chemical binding]; other site
1170562007403	Mg2+ binding site [ion binding]; other site
1170562007404	G-X-G motif; other site
1170562007405	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
1170562007406	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1170562007407	HlyD family secretion protein; Region: HlyD_3; pfam13437
1170562007408	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1170562007409	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1170562007410	ligand binding site [chemical binding]; other site
1170562007411	flexible hinge region; other site
1170562007412	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
1170562007413	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259
1170562007414	putative active site [active]
1170562007415	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1170562007416	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1170562007417	Walker A/P-loop; other site
1170562007418	ATP binding site [chemical binding]; other site
1170562007419	Q-loop/lid; other site
1170562007420	ABC transporter signature motif; other site
1170562007421	Walker B; other site
1170562007422	D-loop; other site
1170562007423	H-loop/switch region; other site
1170562007424	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
1170562007425	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
1170562007426	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1170562007427	This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818
1170562007428	putative ADP-binding pocket [chemical binding]; other site
1170562007429	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
1170562007430	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
1170562007431	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1170562007432	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562007433	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1170562007434	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1170562007435	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562007436	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562007437	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562007438	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1170562007439	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562007440	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
1170562007441	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562007442	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562007443	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562007444	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562007445	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
1170562007446	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
1170562007447	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
1170562007448	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1170562007449	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1170562007450	dimerization interface [polypeptide binding]; other site
1170562007451	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562007452	dimer interface [polypeptide binding]; other site
1170562007453	phosphorylation site [posttranslational modification]
1170562007454	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562007455	ATP binding site [chemical binding]; other site
1170562007456	Mg2+ binding site [ion binding]; other site
1170562007457	G-X-G motif; other site
1170562007458	Protein of unknown function (DUF2874); Region: DUF2874; pfam11396
1170562007459	Domain of unknown function (DUF4114); Region: DUF4114; pfam13448
1170562007460	Domain of unknown function (DUF4114); Region: DUF4114; pfam13448
1170562007461	Domain of unknown function (DUF4114); Region: DUF4114; pfam13448
1170562007462	Domain of unknown function (DUF4114); Region: DUF4114; pfam13448
1170562007463	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
1170562007464	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
1170562007465	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
1170562007466	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
1170562007467	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1170562007468	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1170562007469	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
1170562007470	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1170562007471	active site
1170562007472	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1170562007473	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1170562007474	active site
1170562007475	Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660
1170562007476	Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369
1170562007477	Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592
1170562007478	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1170562007479	anti sigma factor interaction site; other site
1170562007480	regulatory phosphorylation site [posttranslational modification]; other site
1170562007481	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
1170562007482	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1170562007483	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
1170562007484	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
1170562007485	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562007486	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562007487	active site
1170562007488	phosphorylation site [posttranslational modification]
1170562007489	intermolecular recognition site; other site
1170562007490	dimerization interface [polypeptide binding]; other site
1170562007491	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
1170562007492	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
1170562007493	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
1170562007494	tetracycline repressor protein TetR; Provisional; Region: PRK13756
1170562007495	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1170562007496	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
1170562007497	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1170562007498	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267
1170562007499	putative NAD(P) binding site [chemical binding]; other site
1170562007500	FOG: WD40 repeat [General function prediction only]; Region: COG2319
1170562007501	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
1170562007502	FOG: WD40 repeat [General function prediction only]; Region: COG2319
1170562007503	structural tetrad; other site
1170562007504	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
1170562007505	structural tetrad; other site
1170562007506	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
1170562007507	structural tetrad; other site
1170562007508	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
1170562007509	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1170562007510	putative active site [active]
1170562007511	putative metal binding site [ion binding]; other site
1170562007512	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1170562007513	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
1170562007514	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1170562007515	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
1170562007516	Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484
1170562007517	active site
1170562007518	catalytic triad [active]
1170562007519	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
1170562007520	Subunit I/III interface [polypeptide binding]; other site
1170562007521	Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553
1170562007522	Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that also...; Region: ArsC_15kD; cd03033
1170562007523	ArsC family; Region: ArsC; pfam03960
1170562007524	putative catalytic residues [active]
1170562007525	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1170562007526	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1170562007527	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
1170562007528	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
1170562007529	dimer interface [polypeptide binding]; other site
1170562007530	active site
1170562007531	Schiff base residues; other site
1170562007532	Tic20-like protein; Region: Tic20; pfam09685
1170562007533	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
1170562007534	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
1170562007535	G1 box; other site
1170562007536	putative GEF interaction site [polypeptide binding]; other site
1170562007537	GTP/Mg2+ binding site [chemical binding]; other site
1170562007538	Switch I region; other site
1170562007539	G2 box; other site
1170562007540	G3 box; other site
1170562007541	Switch II region; other site
1170562007542	G4 box; other site
1170562007543	G5 box; other site
1170562007544	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
1170562007545	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
1170562007546	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562007547	binding surface
1170562007548	TPR motif; other site
1170562007549	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562007550	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562007551	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562007552	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562007553	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562007554	binding surface
1170562007555	TPR motif; other site
1170562007556	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562007557	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562007558	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562007559	binding surface
1170562007560	TPR motif; other site
1170562007561	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562007562	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562007563	TPR motif; other site
1170562007564	binding surface
1170562007565	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562007566	binding surface
1170562007567	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562007568	TPR motif; other site
1170562007569	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562007570	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562007571	CHAT domain; Region: CHAT; pfam12770
1170562007572	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
1170562007573	RNA recognition motif; Region: RRM; smart00360
1170562007574	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
1170562007575	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
1170562007576	putative ADP-binding pocket [chemical binding]; other site
1170562007577	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
1170562007578	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
1170562007579	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
1170562007580	putative active site [active]
1170562007581	putative NTP binding site [chemical binding]; other site
1170562007582	putative nucleic acid binding site [nucleotide binding]; other site
1170562007583	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
1170562007584	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
1170562007585	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1170562007586	active site
1170562007587	Hemerythrin-like domain; Region: Hr-like; cd12108
1170562007588	Fe binding site [ion binding]; other site
1170562007589	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1170562007590	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
1170562007591	Peptidase family M50; Region: Peptidase_M50; pfam02163
1170562007592	active site
1170562007593	putative substrate binding region [chemical binding]; other site
1170562007594	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50.  CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801
1170562007595	FOG: CBS domain [General function prediction only]; Region: COG0517
1170562007596	putative addiction module component, TIGR02574 family; Region: stabl_TIGR02574
1170562007597	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
1170562007598	XisI protein; Region: XisI; pfam08869
1170562007599	XisH protein; Region: XisH; pfam08814
1170562007600	NB-ARC domain; Region: NB-ARC; pfam00931
1170562007601	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562007602	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562007603	binding surface
1170562007604	TPR motif; other site
1170562007605	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562007606	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562007607	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562007608	binding surface
1170562007609	TPR motif; other site
1170562007610	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562007611	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562007612	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562007613	binding surface
1170562007614	TPR motif; other site
1170562007615	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562007616	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562007617	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562007618	binding surface
1170562007619	TPR motif; other site
1170562007620	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562007621	aspartate aminotransferase; Provisional; Region: PRK05942
1170562007622	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1170562007623	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1170562007624	homodimer interface [polypeptide binding]; other site
1170562007625	catalytic residue [active]
1170562007626	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
1170562007627	Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172
1170562007628	putative active site [active]
1170562007629	metal binding site [ion binding]; metal-binding site
1170562007630	Protein of function (DUF2518); Region: DUF2518; pfam10726
1170562007631	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
1170562007632	putative active site [active]
1170562007633	PemK-like protein; Region: PemK; cl00995
1170562007634	Growth regulator [Signal transduction mechanisms]; Region: MazE; COG2336
1170562007635	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
1170562007636	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
1170562007637	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562007638	binding surface
1170562007639	TPR motif; other site
1170562007640	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1170562007641	putative active site [active]
1170562007642	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1170562007643	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1170562007644	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
1170562007645	HlyD family secretion protein; Region: HlyD_3; pfam13437
1170562007646	DevC protein; Region: devC; TIGR01185
1170562007647	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1170562007648	FtsX-like permease family; Region: FtsX; pfam02687
1170562007649	ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982
1170562007650	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1170562007651	Walker A/P-loop; other site
1170562007652	ATP binding site [chemical binding]; other site
1170562007653	Q-loop/lid; other site
1170562007654	ABC transporter signature motif; other site
1170562007655	Walker B; other site
1170562007656	D-loop; other site
1170562007657	H-loop/switch region; other site
1170562007658	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1170562007659	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562007660	active site
1170562007661	phosphorylation site [posttranslational modification]
1170562007662	intermolecular recognition site; other site
1170562007663	dimerization interface [polypeptide binding]; other site
1170562007664	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1170562007665	DNA binding site [nucleotide binding]
1170562007666	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562007667	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562007668	active site
1170562007669	phosphorylation site [posttranslational modification]
1170562007670	intermolecular recognition site; other site
1170562007671	dimerization interface [polypeptide binding]; other site
1170562007672	Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124
1170562007673	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1170562007674	dimer interface [polypeptide binding]; other site
1170562007675	motif 1; other site
1170562007676	active site
1170562007677	motif 2; other site
1170562007678	motif 3; other site
1170562007679	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
1170562007680	anticodon binding site; other site
1170562007681	argininosuccinate synthase; Provisional; Region: PRK13820
1170562007682	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
1170562007683	ANP binding site [chemical binding]; other site
1170562007684	Substrate Binding Site II [chemical binding]; other site
1170562007685	Substrate Binding Site I [chemical binding]; other site
1170562007686	tellurite resistance protein terB; Region: terB; cd07176
1170562007687	putative metal binding site [ion binding]; other site
1170562007688	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
1170562007689	hydrolase, alpha/beta fold family protein; Region: PLN02824
1170562007690	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
1170562007691	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
1170562007692	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
1170562007693	TLC ATP/ADP transporter; Region: TLC; cl03940
1170562007694	HEAT repeats; Region: HEAT_2; pfam13646
1170562007695	DNA methylase; Region: N6_N4_Mtase; cl17433
1170562007696	Restriction endonuclease BsobI; Region: Endonuc-BsobI; pfam09194
1170562007697	Uncharacterized integral membrane protein (DUF2301); Region: DUF2301; cl02241
1170562007698	Fasciclin domain; Region: Fasciclin; pfam02469
1170562007699	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1170562007700	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562007701	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562007702	TPR repeat; Region: TPR_11; pfam13414
1170562007703	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562007704	binding surface
1170562007705	TPR motif; other site
1170562007706	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1170562007707	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1170562007708	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1170562007709	Walker A/P-loop; other site
1170562007710	ATP binding site [chemical binding]; other site
1170562007711	Q-loop/lid; other site
1170562007712	ABC transporter signature motif; other site
1170562007713	Walker B; other site
1170562007714	D-loop; other site
1170562007715	H-loop/switch region; other site
1170562007716	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
1170562007717	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
1170562007718	SLBB domain; Region: SLBB; pfam10531
1170562007719	SLBB domain; Region: SLBB; pfam10531
1170562007720	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
1170562007721	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1170562007722	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
1170562007723	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
1170562007724	Protein of unknown function (DUF2281); Region: DUF2281; cl02355
1170562007725	C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733
1170562007726	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1170562007727	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
1170562007728	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020
1170562007729	HEAT repeats; Region: HEAT_2; pfam13646
1170562007730	protein binding surface [polypeptide binding]; other site
1170562007731	HEAT repeats; Region: HEAT_2; pfam13646
1170562007732	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
1170562007733	Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze  the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase...; Region: ADA_AMPD; cd00443
1170562007734	active site
1170562007735	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1170562007736	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
1170562007737	catalytic triad [active]
1170562007738	Transcriptional regulator [Transcription]; Region: LytR; COG1316
1170562007739	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
1170562007740	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
1170562007741	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
1170562007742	Substrate binding site; other site
1170562007743	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
1170562007744	ABC1 family; Region: ABC1; cl17513
1170562007745	Protein of unknown function (DUF1517); Region: DUF1517; cl01807
1170562007746	protein-export membrane protein SecD; Region: secD; TIGR01129
1170562007747	Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699
1170562007748	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1170562007749	G1 box; other site
1170562007750	GTP/Mg2+ binding site [chemical binding]; other site
1170562007751	G2 box; other site
1170562007752	Switch I region; other site
1170562007753	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1170562007754	G3 box; other site
1170562007755	Switch II region; other site
1170562007756	G4 box; other site
1170562007757	KGK domain; Region: KGK; pfam08872
1170562007758	KGK domain; Region: KGK; pfam08872
1170562007759	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
1170562007760	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1170562007761	active site
1170562007762	3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13396
1170562007763	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
1170562007764	Protein of unknown function (DUF3464); Region: DUF3464; pfam11947
1170562007765	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
1170562007766	16S/18S rRNA binding site [nucleotide binding]; other site
1170562007767	S13e-L30e interaction site [polypeptide binding]; other site
1170562007768	25S rRNA binding site [nucleotide binding]; other site
1170562007769	transaldolase-like protein; Provisional; Region: PTZ00411
1170562007770	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
1170562007771	active site
1170562007772	dimer interface [polypeptide binding]; other site
1170562007773	catalytic residue [active]
1170562007774	CHAT domain; Region: CHAT; cl17868
1170562007775	radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167
1170562007776	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1170562007777	FeS/SAM binding site; other site
1170562007778	Protein of unknown function (DUF3641); Region: DUF3641; pfam12345
1170562007779	Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; pfam10069
1170562007780	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1170562007781	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562007782	dimer interface [polypeptide binding]; other site
1170562007783	phosphorylation site [posttranslational modification]
1170562007784	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562007785	ATP binding site [chemical binding]; other site
1170562007786	Mg2+ binding site [ion binding]; other site
1170562007787	G-X-G motif; other site
1170562007788	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
1170562007789	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1170562007790	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1170562007791	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1170562007792	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
1170562007793	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1170562007794	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
1170562007795	Probable transposase; Region: OrfB_IS605; pfam01385
1170562007796	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
1170562007797	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562007798	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1170562007799	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1170562007800	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1170562007801	Walker A/P-loop; other site
1170562007802	ATP binding site [chemical binding]; other site
1170562007803	Q-loop/lid; other site
1170562007804	ABC transporter signature motif; other site
1170562007805	Walker B; other site
1170562007806	D-loop; other site
1170562007807	H-loop/switch region; other site
1170562007808	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1170562007809	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1170562007810	TAP-like protein; Region: Abhydrolase_4; pfam08386
1170562007811	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1170562007812	FAD binding domain; Region: FAD_binding_4; pfam01565
1170562007813	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1170562007814	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1170562007815	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
1170562007816	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
1170562007817	Alkaline phosphatase homologues; Region: alkPPc; smart00098
1170562007818	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
1170562007819	active site
1170562007820	dimer interface [polypeptide binding]; other site
1170562007821	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
1170562007822	MltA specific insert domain; Region: MltA; smart00925
1170562007823	3D domain; Region: 3D; pfam06725
1170562007824	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
1170562007825	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
1170562007826	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
1170562007827	putative active site [active]
1170562007828	putative NTP binding site [chemical binding]; other site
1170562007829	putative nucleic acid binding site [nucleotide binding]; other site
1170562007830	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
1170562007831	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
1170562007832	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1170562007833	active site
1170562007834	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299
1170562007835	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1170562007836	metal binding site 2 [ion binding]; metal-binding site
1170562007837	putative DNA binding helix; other site
1170562007838	metal binding site 1 [ion binding]; metal-binding site
1170562007839	dimer interface [polypeptide binding]; other site
1170562007840	structural Zn2+ binding site [ion binding]; other site
1170562007841	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
1170562007842	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1170562007843	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
1170562007844	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1170562007845	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1170562007846	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1170562007847	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
1170562007848	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
1170562007849	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
1170562007850	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
1170562007851	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1170562007852	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1170562007853	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562007854	dimer interface [polypeptide binding]; other site
1170562007855	phosphorylation site [posttranslational modification]
1170562007856	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562007857	ATP binding site [chemical binding]; other site
1170562007858	Mg2+ binding site [ion binding]; other site
1170562007859	G-X-G motif; other site
1170562007860	Protein kinase domain; Region: Pkinase; pfam00069
1170562007861	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1170562007862	active site
1170562007863	ATP binding site [chemical binding]; other site
1170562007864	substrate binding site [chemical binding]; other site
1170562007865	activation loop (A-loop); other site
1170562007866	PAS fold; Region: PAS_4; pfam08448
1170562007867	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562007868	putative active site [active]
1170562007869	heme pocket [chemical binding]; other site
1170562007870	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1170562007871	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562007872	dimer interface [polypeptide binding]; other site
1170562007873	phosphorylation site [posttranslational modification]
1170562007874	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562007875	ATP binding site [chemical binding]; other site
1170562007876	Mg2+ binding site [ion binding]; other site
1170562007877	G-X-G motif; other site
1170562007878	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
1170562007879	protein-export membrane protein SecD; Region: secD; TIGR01129
1170562007880	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
1170562007881	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
1170562007882	Protein export membrane protein; Region: SecD_SecF; pfam02355
1170562007883	Protein of unknown function DUF262; Region: DUF262; pfam03235
1170562007884	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1170562007885	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1170562007886	Coenzyme A binding pocket [chemical binding]; other site
1170562007887	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1170562007888	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562007889	dimer interface [polypeptide binding]; other site
1170562007890	phosphorylation site [posttranslational modification]
1170562007891	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
1170562007892	mce related protein; Region: MCE; pfam02470
1170562007893	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
1170562007894	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
1170562007895	Walker A/P-loop; other site
1170562007896	ATP binding site [chemical binding]; other site
1170562007897	Q-loop/lid; other site
1170562007898	ABC transporter signature motif; other site
1170562007899	Walker B; other site
1170562007900	D-loop; other site
1170562007901	H-loop/switch region; other site
1170562007902	carotene isomerase; Region: carot_isom; TIGR02730
1170562007903	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1170562007904	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
1170562007905	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
1170562007906	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562007907	binding surface
1170562007908	TPR motif; other site
1170562007909	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562007910	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562007911	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562007912	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562007913	binding surface
1170562007914	TPR motif; other site
1170562007915	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562007916	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562007917	binding surface
1170562007918	TPR motif; other site
1170562007919	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562007920	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562007921	binding surface
1170562007922	TPR motif; other site
1170562007923	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562007924	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562007925	binding surface
1170562007926	TPR motif; other site
1170562007927	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562007928	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562007929	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562007930	TPR motif; other site
1170562007931	binding surface
1170562007932	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562007933	CHAT domain; Region: CHAT; pfam12770
1170562007934	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
1170562007935	NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390
1170562007936	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
1170562007937	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1170562007938	NAD(P)H-quinone oxidoreductase subunit M; Validated; Region: PRK07363
1170562007939	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1170562007940	CO2 hydration protein (ChpXY); Region: ChpXY; cl10905
1170562007941	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
1170562007942	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
1170562007943	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
1170562007944	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
1170562007945	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1170562007946	Ligand Binding Site [chemical binding]; other site
1170562007947	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
1170562007948	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
1170562007949	NAD binding site [chemical binding]; other site
1170562007950	dimerization interface [polypeptide binding]; other site
1170562007951	product binding site; other site
1170562007952	substrate binding site [chemical binding]; other site
1170562007953	zinc binding site [ion binding]; other site
1170562007954	catalytic residues [active]
1170562007955	Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730
1170562007956	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
1170562007957	Cellulose binding domain; Region: CBM_2; pfam00553
1170562007958	DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597
1170562007959	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
1170562007960	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
1170562007961	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
1170562007962	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
1170562007963	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
1170562007964	Rpb1 - Rpb5 interaction site [polypeptide binding]; other site
1170562007965	Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168
1170562007966	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1170562007967	DNA binding site [nucleotide binding]
1170562007968	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
1170562007969	DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625
1170562007970	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
1170562007971	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
1170562007972	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
1170562007973	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
1170562007974	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1170562007975	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
1170562007976	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1170562007977	RPB10 interaction site [polypeptide binding]; other site
1170562007978	RPB1 interaction site [polypeptide binding]; other site
1170562007979	RPB11 interaction site [polypeptide binding]; other site
1170562007980	RPB3 interaction site [polypeptide binding]; other site
1170562007981	RPB12 interaction site [polypeptide binding]; other site
1170562007982	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1170562007983	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
1170562007984	active site
1170562007985	ribosomal protein S20; Region: rps20; CHL00102
1170562007986	ribulose bisphosphate carboxylase/oxygenase activase -RuBisCO activase (RCA); Provisional; Region: PLN00020
1170562007987	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
1170562007988	putative multimerization interface [polypeptide binding]; other site
1170562007989	DevC protein; Region: devC; TIGR01185
1170562007990	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1170562007991	FtsX-like permease family; Region: FtsX; pfam02687
1170562007992	Ion channel; Region: Ion_trans_2; pfam07885
1170562007993	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1170562007994	TrkA-N domain; Region: TrkA_N; pfam02254
1170562007995	TrkA-C domain; Region: TrkA_C; pfam02080
1170562007996	Predicted bile acid beta-glucosidase [Carbohydrate transport and metabolism]; Region: COG4354
1170562007997	beta-Glucocerebrosidase 2 N terminal; Region: GBA2_N; pfam12215
1170562007998	Protein of unknown function, DUF608; Region: DUF608; pfam04685
1170562007999	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1170562008000	putative active site [active]
1170562008001	GIY-YIG domain found in CAXIP1-like proteins, iron-sulfur cluster assembly proteins, and similar proteins; Region: GIY-YIG_AtGrxS16_like; cd10450
1170562008002	GIY-YIG motif/motif A; other site
1170562008003	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
1170562008004	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1170562008005	DXD motif; other site
1170562008006	PilZ domain; Region: PilZ; pfam07238
1170562008007	Bacterial cellulose synthase subunit; Region: BcsB; pfam03170
1170562008008	Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351
1170562008009	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
1170562008010	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562008011	binding surface
1170562008012	TPR motif; other site
1170562008013	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562008014	TPR motif; other site
1170562008015	binding surface
1170562008016	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1170562008017	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562008018	TPR motif; other site
1170562008019	binding surface
1170562008020	Carbohydrate-selective porin, OprB family; Region: OprB; cl17816
1170562008021	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1170562008022	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
1170562008023	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
1170562008024	active site
1170562008025	catalytic triad [active]
1170562008026	oxyanion hole [active]
1170562008027	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527
1170562008028	multimerization interface [polypeptide binding]; other site
1170562008029	RbcX protein; Region: RcbX; pfam02341
1170562008030	ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit; Region: rbcL; CHL00040
1170562008031	Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212
1170562008032	homodimer interface [polypeptide binding]; other site
1170562008033	active site
1170562008034	heterodimer interface [polypeptide binding]; other site
1170562008035	catalytic residue [active]
1170562008036	metal binding site [ion binding]; metal-binding site
1170562008037	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
1170562008038	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
1170562008039	oligomerization interface [polypeptide binding]; other site
1170562008040	active site
1170562008041	metal binding site [ion binding]; metal-binding site
1170562008042	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
1170562008043	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
1170562008044	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
1170562008045	ligand binding site [chemical binding]; other site
1170562008046	homodimer interface [polypeptide binding]; other site
1170562008047	NAD(P) binding site [chemical binding]; other site
1170562008048	trimer interface B [polypeptide binding]; other site
1170562008049	trimer interface A [polypeptide binding]; other site
1170562008050	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
1170562008051	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
1170562008052	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
1170562008053	Protein of unknown function DUF262; Region: DUF262; pfam03235
1170562008054	Uncharacterized conserved protein [Function unknown]; Region: COG1479
1170562008055	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
1170562008056	XisI protein; Region: XisI; pfam08869
1170562008057	XisH protein; Region: XisH; pfam08814
1170562008058	hypothetical protein; Provisional; Region: PRK02724
1170562008059	haloacid dehalogenase superfamily, subfamily IA hydrolase, TIGR01548; Region: HAD-SF-IA-hyp1
1170562008060	haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549
1170562008061	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
1170562008062	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1170562008063	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
1170562008064	hypothetical protein; Provisional; Region: PRK02237
1170562008065	Probable cobalt transporter subunit (CbtB); Region: CbtB; cl09723
1170562008066	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
1170562008067	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562008068	binding surface
1170562008069	TPR motif; other site
1170562008070	TPR repeat; Region: TPR_11; pfam13414
1170562008071	TPR repeat; Region: TPR_11; pfam13414
1170562008072	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562008073	binding surface
1170562008074	TPR motif; other site
1170562008075	TPR repeat; Region: TPR_11; pfam13414
1170562008076	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562008077	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562008078	active site
1170562008079	phosphorylation site [posttranslational modification]
1170562008080	intermolecular recognition site; other site
1170562008081	dimerization interface [polypeptide binding]; other site
1170562008082	DNA gyrase subunit A; Validated; Region: PRK05560
1170562008083	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1170562008084	CAP-like domain; other site
1170562008085	active site
1170562008086	primary dimer interface [polypeptide binding]; other site
1170562008087	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1170562008088	light-harvesting-like protein 3; Provisional; Region: PLN00014
1170562008089	RNA polymerase sigma factor RpoD; Validated; Region: PRK07406
1170562008090	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1170562008091	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1170562008092	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1170562008093	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1170562008094	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1170562008095	DNA binding residues [nucleotide binding]
1170562008096	chaperone protein DnaJ; Provisional; Region: PRK14299
1170562008097	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1170562008098	HSP70 interaction site [polypeptide binding]; other site
1170562008099	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1170562008100	dimer interface [polypeptide binding]; other site
1170562008101	molecular chaperone DnaK; Provisional; Region: PRK13410
1170562008102	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
1170562008103	nucleotide binding site [chemical binding]; other site
1170562008104	NEF interaction site [polypeptide binding]; other site
1170562008105	SBD interface [polypeptide binding]; other site
1170562008106	M28 Zn-Peptidases; Region: M28_like_1; cd05640
1170562008107	Peptidase family M28; Region: Peptidase_M28; pfam04389
1170562008108	metal binding site [ion binding]; metal-binding site
1170562008109	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1170562008110	Domain of unknown function DUF21; Region: DUF21; pfam01595
1170562008111	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1170562008112	Transporter associated domain; Region: CorC_HlyC; smart01091
1170562008113	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
1170562008114	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
1170562008115	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1170562008116	active site
1170562008117	metal binding site [ion binding]; metal-binding site
1170562008118	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1170562008119	S-adenosylmethionine binding site [chemical binding]; other site
1170562008120	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
1170562008121	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
1170562008122	Chain length determinant protein; Region: Wzz; cl15801
1170562008123	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
1170562008124	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1170562008125	Magnesium ion binding site [ion binding]; other site
1170562008126	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1170562008127	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
1170562008128	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
1170562008129	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1170562008130	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
1170562008131	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
1170562008132	Walker A/P-loop; other site
1170562008133	ATP binding site [chemical binding]; other site
1170562008134	Q-loop/lid; other site
1170562008135	ABC transporter signature motif; other site
1170562008136	Walker B; other site
1170562008137	D-loop; other site
1170562008138	H-loop/switch region; other site
1170562008139	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
1170562008140	putative carbohydrate binding site [chemical binding]; other site
1170562008141	WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358
1170562008142	putative trimer interface [polypeptide binding]; other site
1170562008143	putative active site [active]
1170562008144	putative substrate binding site [chemical binding]; other site
1170562008145	putative CoA binding site [chemical binding]; other site
1170562008146	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1170562008147	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1170562008148	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
1170562008149	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1170562008150	inhibitor-cofactor binding pocket; inhibition site
1170562008151	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1170562008152	catalytic residue [active]
1170562008153	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
1170562008154	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
1170562008155	trimer interface [polypeptide binding]; other site
1170562008156	active site
1170562008157	substrate binding site [chemical binding]; other site
1170562008158	CoA binding site [chemical binding]; other site
1170562008159	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1170562008160	NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180
1170562008161	NAD(P) binding site [chemical binding]; other site
1170562008162	active site
1170562008163	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
1170562008164	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1170562008165	inhibitor-cofactor binding pocket; inhibition site
1170562008166	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1170562008167	catalytic residue [active]
1170562008168	Domain of unknown function (DUF4082); Region: DUF4082; pfam13313
1170562008169	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
1170562008170	Domain of unknown function (DUF4082); Region: DUF4082; pfam13313
1170562008171	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
1170562008172	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1170562008173	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1170562008174	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1170562008175	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1170562008176	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1170562008177	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1170562008178	active site
1170562008179	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1170562008180	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
1170562008181	metal-binding site
1170562008182	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1170562008183	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
1170562008184	metal-binding site
1170562008185	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
1170562008186	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1170562008187	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1170562008188	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1170562008189	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1170562008190	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
1170562008191	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1170562008192	This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821
1170562008193	putative ADP-binding pocket [chemical binding]; other site
1170562008194	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1170562008195	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
1170562008196	putative metal binding site; other site
1170562008197	Polysaccharide lyase family 8, N terminal alpha-helical domain; Region: Lyase_8_N; pfam08124
1170562008198	NusA N-terminal domain; Region: NusA_N; pfam08529
1170562008199	putative acyl transferase; Provisional; Region: PRK10502
1170562008200	wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825
1170562008201	putative trimer interface [polypeptide binding]; other site
1170562008202	putative active site [active]
1170562008203	putative substrate binding site [chemical binding]; other site
1170562008204	putative CoA binding site [chemical binding]; other site
1170562008205	Domain of unknown function DUF87; Region: DUF87; pfam01935
1170562008206	AAA-like domain; Region: AAA_10; pfam12846
1170562008207	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562008208	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562008209	binding surface
1170562008210	TPR motif; other site
1170562008211	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562008212	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562008213	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562008214	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562008215	binding surface
1170562008216	TPR motif; other site
1170562008217	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562008218	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562008219	binding surface
1170562008220	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562008221	TPR motif; other site
1170562008222	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562008223	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
1170562008224	Sporulation and spore germination; Region: Germane; pfam10646
1170562008225	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1170562008226	putative DNA binding site [nucleotide binding]; other site
1170562008227	putative Zn2+ binding site [ion binding]; other site
1170562008228	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
1170562008229	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1170562008230	carboxyltransferase (CT) interaction site; other site
1170562008231	biotinylation site [posttranslational modification]; other site
1170562008232	elongation factor P; Validated; Region: PRK00529
1170562008233	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
1170562008234	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
1170562008235	RNA binding site [nucleotide binding]; other site
1170562008236	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
1170562008237	RNA binding site [nucleotide binding]; other site
1170562008238	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
1170562008239	Putative addiction module component; Region: Unstab_antitox; pfam09720
1170562008240	Helix-turn-helix domain; Region: HTH_28; pfam13518
1170562008241	Winged helix-turn helix; Region: HTH_29; pfam13551
1170562008242	Homeodomain-like domain; Region: HTH_32; pfam13565
1170562008243	DDE superfamily endonuclease; Region: DDE_3; pfam13358
1170562008244	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
1170562008245	N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789
1170562008246	active site
1170562008247	catalytic site [active]
1170562008248	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
1170562008249	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
1170562008250	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
1170562008251	catalytic residue [active]
1170562008252	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1170562008253	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1170562008254	Coenzyme A binding pocket [chemical binding]; other site
1170562008255	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1170562008256	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
1170562008257	homotrimer interface [polypeptide binding]; other site
1170562008258	Walker A motif; other site
1170562008259	GTP binding site [chemical binding]; other site
1170562008260	Walker B motif; other site
1170562008261	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1170562008262	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1170562008263	active site
1170562008264	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
1170562008265	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1170562008266	putative metal binding site; other site
1170562008267	putative acyl transferase; Provisional; Region: PRK10502
1170562008268	wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825
1170562008269	putative trimer interface [polypeptide binding]; other site
1170562008270	putative active site [active]
1170562008271	putative substrate binding site [chemical binding]; other site
1170562008272	putative CoA binding site [chemical binding]; other site
1170562008273	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562008274	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562008275	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562008276	binding surface
1170562008277	TPR motif; other site
1170562008278	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562008279	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562008280	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562008281	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562008282	binding surface
1170562008283	TPR motif; other site
1170562008284	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562008285	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562008286	Tetratricopeptide repeat; Region: TPR_10; pfam13374
1170562008287	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562008288	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562008289	binding surface
1170562008290	TPR motif; other site
1170562008291	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562008292	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562008293	Tetratricopeptide repeat; Region: TPR_10; pfam13374
1170562008294	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562008295	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562008296	binding surface
1170562008297	TPR motif; other site
1170562008298	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562008299	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562008300	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562008301	binding surface
1170562008302	TPR motif; other site
1170562008303	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562008304	AAA ATPase domain; Region: AAA_16; pfam13191
1170562008305	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1170562008306	putative active site [active]
1170562008307	recombination protein RecR; Reviewed; Region: recR; PRK00076
1170562008308	RecR protein; Region: RecR; pfam02132
1170562008309	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
1170562008310	putative active site [active]
1170562008311	putative metal-binding site [ion binding]; other site
1170562008312	tetramer interface [polypeptide binding]; other site
1170562008313	Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748
1170562008314	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
1170562008315	Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683
1170562008316	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
1170562008317	Domain of unknown function (DUF3368); Region: DUF3368; pfam11848
1170562008318	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
1170562008319	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
1170562008320	GatB domain; Region: GatB_Yqey; smart00845
1170562008321	ChaB; Region: ChaB; pfam06150
1170562008322	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
1170562008323	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
1170562008324	dimerization interface [polypeptide binding]; other site
1170562008325	DPS ferroxidase diiron center [ion binding]; other site
1170562008326	ion pore; other site
1170562008327	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1170562008328	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426
1170562008329	folate binding site [chemical binding]; other site
1170562008330	NADP+ binding site [chemical binding]; other site
1170562008331	RibD C-terminal domain; Region: RibD_C; cl17279
1170562008332	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1170562008333	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1170562008334	protein binding site [polypeptide binding]; other site
1170562008335	Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078
1170562008336	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306
1170562008337	active site
1170562008338	catalytic residues [active]
1170562008339	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1170562008340	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1170562008341	active site
1170562008342	ATP binding site [chemical binding]; other site
1170562008343	substrate binding site [chemical binding]; other site
1170562008344	activation loop (A-loop); other site
1170562008345	gliding motility-associated lipoprotein GldK; Region: GldK_short; TIGR03529
1170562008346	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
1170562008347	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
1170562008348	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
1170562008349	G1 box; other site
1170562008350	GTP/Mg2+ binding site [chemical binding]; other site
1170562008351	Switch I region; other site
1170562008352	G2 box; other site
1170562008353	Switch II region; other site
1170562008354	G3 box; other site
1170562008355	G4 box; other site
1170562008356	G5 box; other site
1170562008357	Domain of unknown function (DUF697); Region: DUF697; pfam05128
1170562008358	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
1170562008359	Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602
1170562008360	putative active site [active]
1170562008361	catalytic site [active]
1170562008362	putative metal binding site [ion binding]; other site
1170562008363	proton extrusion protein PcxA; Provisional; Region: PRK02507
1170562008364	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
1170562008365	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
1170562008366	active site
1170562008367	Zn binding site [ion binding]; other site
1170562008368	ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226
1170562008369	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1170562008370	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1170562008371	dimerization interface [polypeptide binding]; other site
1170562008372	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562008373	dimer interface [polypeptide binding]; other site
1170562008374	phosphorylation site [posttranslational modification]
1170562008375	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562008376	ATP binding site [chemical binding]; other site
1170562008377	Mg2+ binding site [ion binding]; other site
1170562008378	G-X-G motif; other site
1170562008379	Uncharacterized conserved protein [Function unknown]; Region: COG5464
1170562008380	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
1170562008381	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
1170562008382	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1170562008383	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
1170562008384	NAD(P) binding site [chemical binding]; other site
1170562008385	RRXRR protein; Region: RRXRR; pfam14239
1170562008386	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1170562008387	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1170562008388	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
1170562008389	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1170562008390	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
1170562008391	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1170562008392	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1170562008393	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1170562008394	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1170562008395	photosystem II protein PsbQ; Region: PS_II_psbQ_bact; TIGR03042
1170562008396	Predicted thiol-disulfide oxidoreductase [General function    prediction only]; Region: COG3011
1170562008397	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
1170562008398	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
1170562008399	nucleotide binding pocket [chemical binding]; other site
1170562008400	K-X-D-G motif; other site
1170562008401	catalytic site [active]
1170562008402	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
1170562008403	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
1170562008404	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
1170562008405	Dimer interface [polypeptide binding]; other site
1170562008406	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
1170562008407	pseudouridine synthase; Region: TIGR00093
1170562008408	active site
1170562008409	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562008410	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
1170562008411	putative active site [active]
1170562008412	heme pocket [chemical binding]; other site
1170562008413	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562008414	dimer interface [polypeptide binding]; other site
1170562008415	phosphorylation site [posttranslational modification]
1170562008416	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562008417	ATP binding site [chemical binding]; other site
1170562008418	Mg2+ binding site [ion binding]; other site
1170562008419	G-X-G motif; other site
1170562008420	putative protein serine/threonine phosphatase; Provisional; Region: PRK14559
1170562008421	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
1170562008422	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
1170562008423	active site
1170562008424	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1170562008425	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1170562008426	phosphopeptide binding site; other site
1170562008427	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1170562008428	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1170562008429	active site
1170562008430	ATP binding site [chemical binding]; other site
1170562008431	substrate binding site [chemical binding]; other site
1170562008432	activation loop (A-loop); other site
1170562008433	methionine sulfoxide reductase A; Provisional; Region: PRK00058
1170562008434	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1170562008435	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1170562008436	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1170562008437	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1170562008438	DNA binding residues [nucleotide binding]
1170562008439	dimerization interface [polypeptide binding]; other site
1170562008440	Protein of unknown function (DUF3386); Region: DUF3386; pfam11866
1170562008441	Transposase IS200 like; Region: Y1_Tnp; pfam01797
1170562008442	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1170562008443	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
1170562008444	Probable transposase; Region: OrfB_IS605; pfam01385
1170562008445	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
1170562008446	cell division protein; Validated; Region: ftsH; CHL00176
1170562008447	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1170562008448	Walker A motif; other site
1170562008449	ATP binding site [chemical binding]; other site
1170562008450	Walker B motif; other site
1170562008451	arginine finger; other site
1170562008452	Peptidase family M41; Region: Peptidase_M41; pfam01434
1170562008453	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562008454	binding surface
1170562008455	TPR motif; other site
1170562008456	TPR repeat; Region: TPR_11; pfam13414
1170562008457	Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846
1170562008458	active site
1170562008459	catalytic triad [active]
1170562008460	oxyanion hole [active]
1170562008461	S-layer homology domain; Region: SLH; pfam00395
1170562008462	S-layer homology domain; Region: SLH; pfam00395
1170562008463	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
1170562008464	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
1170562008465	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
1170562008466	Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471
1170562008467	Predicted methyltransferases [General function prediction only]; Region: COG0313
1170562008468	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
1170562008469	putative SAM binding site [chemical binding]; other site
1170562008470	putative homodimer interface [polypeptide binding]; other site
1170562008471	Ribokinase-like subgroup B.  Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945
1170562008472	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1170562008473	substrate binding site [chemical binding]; other site
1170562008474	ATP binding site [chemical binding]; other site
1170562008475	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1170562008476	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
1170562008477	active site
1170562008478	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
1170562008479	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1170562008480	FMN binding site [chemical binding]; other site
1170562008481	active site
1170562008482	catalytic residues [active]
1170562008483	substrate binding site [chemical binding]; other site
1170562008484	Predicted membrane protein [Function unknown]; Region: XynA; COG2314
1170562008485	Short C-terminal domain; Region: SHOCT; pfam09851
1170562008486	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
1170562008487	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
1170562008488	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
1170562008489	competence damage-inducible protein A; Provisional; Region: PRK00549
1170562008490	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
1170562008491	putative MPT binding site; other site
1170562008492	Competence-damaged protein; Region: CinA; pfam02464
1170562008493	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
1170562008494	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1170562008495	dimer interface [polypeptide binding]; other site
1170562008496	active site
1170562008497	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1170562008498	folate binding site [chemical binding]; other site
1170562008499	chloroplast protein import component, Tic20 family; Region: 3a0901s05TIC20; TIGR00994
1170562008500	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1170562008501	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1170562008502	Ribosomal protein S6; Region: Ribosomal_S6; pfam01250
1170562008503	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
1170562008504	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1170562008505	anti sigma factor interaction site; other site
1170562008506	regulatory phosphorylation site [posttranslational modification]; other site
1170562008507	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
1170562008508	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1170562008509	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
1170562008510	MoaE interaction surface [polypeptide binding]; other site
1170562008511	MoeB interaction surface [polypeptide binding]; other site
1170562008512	thiocarboxylated glycine; other site
1170562008513	Phosphoglycerate kinase; Region: PGK; pfam00162
1170562008514	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
1170562008515	substrate binding site [chemical binding]; other site
1170562008516	hinge regions; other site
1170562008517	ADP binding site [chemical binding]; other site
1170562008518	catalytic site [active]
1170562008519	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1170562008520	Ligand Binding Site [chemical binding]; other site
1170562008521	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
1170562008522	Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318
1170562008523	active site
1170562008524	Na/Ca binding site [ion binding]; other site
1170562008525	catalytic site [active]
1170562008526	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
1170562008527	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1170562008528	C-terminal domain interface [polypeptide binding]; other site
1170562008529	GSH binding site (G-site) [chemical binding]; other site
1170562008530	dimer interface [polypeptide binding]; other site
1170562008531	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
1170562008532	N-terminal domain interface [polypeptide binding]; other site
1170562008533	dimer interface [polypeptide binding]; other site
1170562008534	substrate binding pocket (H-site) [chemical binding]; other site
1170562008535	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
1170562008536	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
1170562008537	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
1170562008538	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562008539	dimer interface [polypeptide binding]; other site
1170562008540	phosphorylation site [posttranslational modification]
1170562008541	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562008542	ATP binding site [chemical binding]; other site
1170562008543	Mg2+ binding site [ion binding]; other site
1170562008544	G-X-G motif; other site
1170562008545	GAF domain; Region: GAF; pfam01590
1170562008546	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1170562008547	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562008548	dimer interface [polypeptide binding]; other site
1170562008549	phosphorylation site [posttranslational modification]
1170562008550	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562008551	ATP binding site [chemical binding]; other site
1170562008552	Mg2+ binding site [ion binding]; other site
1170562008553	G-X-G motif; other site
1170562008554	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1170562008555	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562008556	active site
1170562008557	phosphorylation site [posttranslational modification]
1170562008558	intermolecular recognition site; other site
1170562008559	dimerization interface [polypeptide binding]; other site
1170562008560	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1170562008561	DNA binding site [nucleotide binding]
1170562008562	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1170562008563	EamA-like transporter family; Region: EamA; pfam00892
1170562008564	EamA-like transporter family; Region: EamA; pfam00892
1170562008565	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1170562008566	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1170562008567	Walker A/P-loop; other site
1170562008568	ATP binding site [chemical binding]; other site
1170562008569	Q-loop/lid; other site
1170562008570	ABC transporter signature motif; other site
1170562008571	Walker B; other site
1170562008572	D-loop; other site
1170562008573	H-loop/switch region; other site
1170562008574	TOBE domain; Region: TOBE_2; pfam08402
1170562008575	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1170562008576	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
1170562008577	Probable transposase; Region: OrfB_IS605; pfam01385
1170562008578	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
1170562008579	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1170562008580	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1170562008581	dimer interface [polypeptide binding]; other site
1170562008582	ssDNA binding site [nucleotide binding]; other site
1170562008583	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1170562008584	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
1170562008585	active site 1 [active]
1170562008586	dimer interface [polypeptide binding]; other site
1170562008587	hexamer interface [polypeptide binding]; other site
1170562008588	active site 2 [active]
1170562008589	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1170562008590	Coenzyme A binding pocket [chemical binding]; other site
1170562008591	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
1170562008592	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1170562008593	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
1170562008594	Lipase (class 2); Region: Lipase_2; pfam01674
1170562008595	FOG: WD40 repeat [General function prediction only]; Region: COG2319
1170562008596	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
1170562008597	structural tetrad; other site
1170562008598	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
1170562008599	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
1170562008600	active site
1170562008601	intersubunit interface [polypeptide binding]; other site
1170562008602	catalytic residue [active]
1170562008603	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1170562008604	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1170562008605	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
1170562008606	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1170562008607	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
1170562008608	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1170562008609	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
1170562008610	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1170562008611	dimerization interface [polypeptide binding]; other site
1170562008612	photosystem II 44 kDa protein; Region: psbC; CHL00035
1170562008613	photosystem II 44 kDa subunit reaction center protein (also called P6 protein, CP43), bacterial and chloroplast; Region: psbC; TIGR01153
1170562008614	D2 subunit  of photosystem II (PS II); Region: Photosystem-II_D2; cd09288
1170562008615	D1 interface; other site
1170562008616	chlorophyll binding site; other site
1170562008617	pheophytin binding site; other site
1170562008618	beta carotene binding site; other site
1170562008619	cytochrome b559 beta interface; other site
1170562008620	quinone binding site; other site
1170562008621	cytochrome b559 alpha interface; other site
1170562008622	protein J interface; other site
1170562008623	protein H interface; other site
1170562008624	protein X interface; other site
1170562008625	core light harvesting protein interface; other site
1170562008626	protein L interface; other site
1170562008627	CP43 interface; other site
1170562008628	protein T interface; other site
1170562008629	Fe binding site [ion binding]; other site
1170562008630	protein M interface; other site
1170562008631	Mn-stabilizing polypeptide interface; other site
1170562008632	bromide binding site; other site
1170562008633	cytochrome c-550 interface; other site
1170562008634	photosystem I assembly protein Ycf4; Provisional; Region: PRK02542
1170562008635	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
1170562008636	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
1170562008637	Hexamer interface [polypeptide binding]; other site
1170562008638	Hexagonal pore residue; other site
1170562008639	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
1170562008640	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
1170562008641	Hexamer interface [polypeptide binding]; other site
1170562008642	Hexagonal pore residue; other site
1170562008643	Protein of unknown function (DUF3146); Region: DUF3146; pfam11344
1170562008644	Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339
1170562008645	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
1170562008646	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
1170562008647	RNase E interface [polypeptide binding]; other site
1170562008648	trimer interface [polypeptide binding]; other site
1170562008649	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
1170562008650	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
1170562008651	RNase E interface [polypeptide binding]; other site
1170562008652	trimer interface [polypeptide binding]; other site
1170562008653	active site
1170562008654	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
1170562008655	putative nucleic acid binding region [nucleotide binding]; other site
1170562008656	G-X-X-G motif; other site
1170562008657	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
1170562008658	RNA binding site [nucleotide binding]; other site
1170562008659	domain interface; other site
1170562008660	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
1170562008661	SNF2 Helicase protein; Region: DUF3670; pfam12419
1170562008662	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1170562008663	ATP binding site [chemical binding]; other site
1170562008664	putative Mg++ binding site [ion binding]; other site
1170562008665	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1170562008666	nucleotide binding region [chemical binding]; other site
1170562008667	ATP-binding site [chemical binding]; other site
1170562008668	Uncharacterized conserved protein [Function unknown]; Region: COG4279
1170562008669	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
1170562008670	Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372
1170562008671	Protein of unknown function (DUF3084); Region: DUF3084; pfam11283
1170562008672	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1170562008673	global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
1170562008674	ligand binding site [chemical binding]; other site
1170562008675	flexible hinge region; other site
1170562008676	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1170562008677	putative switch regulator; other site
1170562008678	non-specific DNA interactions [nucleotide binding]; other site
1170562008679	DNA binding site [nucleotide binding]
1170562008680	sequence specific DNA binding site [nucleotide binding]; other site
1170562008681	putative cAMP binding site [chemical binding]; other site
1170562008682	enoyl-(acyl carrier protein) reductase; Validated; Region: PRK07370
1170562008683	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
1170562008684	NAD binding site [chemical binding]; other site
1170562008685	homotetramer interface [polypeptide binding]; other site
1170562008686	homodimer interface [polypeptide binding]; other site
1170562008687	substrate binding site [chemical binding]; other site
1170562008688	active site
1170562008689	ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; cl00397
1170562008690	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
1170562008691	PDGLE domain; Region: PDGLE; pfam13190
1170562008692	Cobalt transport protein; Region: CbiQ; cl00463
1170562008693	NurA nuclease; Region: NurA; smart00933
1170562008694	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1170562008695	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1170562008696	phosphopeptide binding site; other site
1170562008697	D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
1170562008698	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
1170562008699	acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK07418
1170562008700	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1170562008701	PYR/PP interface [polypeptide binding]; other site
1170562008702	dimer interface [polypeptide binding]; other site
1170562008703	TPP binding site [chemical binding]; other site
1170562008704	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1170562008705	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
1170562008706	TPP-binding site [chemical binding]; other site
1170562008707	dimer interface [polypeptide binding]; other site
1170562008708	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
1170562008709	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
1170562008710	imidazoleglycerol-phosphate dehydratase; Region: PLN02800
1170562008711	putative active site pocket [active]
1170562008712	4-fold oligomerization interface [polypeptide binding]; other site
1170562008713	metal binding residues [ion binding]; metal-binding site
1170562008714	3-fold/trimer interface [polypeptide binding]; other site
1170562008715	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
1170562008716	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
1170562008717	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
1170562008718	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473
1170562008719	catalytic triad [active]
1170562008720	putative active site [active]
1170562008721	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
1170562008722	hypothetical protein; Reviewed; Region: PRK09588
1170562008723	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1170562008724	phosphopeptide binding site; other site
1170562008725	Transglycosylase; Region: Transgly; pfam00912
1170562008726	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
1170562008727	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1170562008728	large tegument protein UL36; Provisional; Region: PHA03247
1170562008729	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
1170562008730	lipoprotein signal peptidase; Provisional; Region: PRK14787
1170562008731	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
1170562008732	PBP superfamily domain; Region: PBP_like_2; cl17296
1170562008733	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
1170562008734	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1170562008735	dimer interface [polypeptide binding]; other site
1170562008736	conserved gate region; other site
1170562008737	putative PBP binding loops; other site
1170562008738	ABC-ATPase subunit interface; other site
1170562008739	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
1170562008740	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1170562008741	dimer interface [polypeptide binding]; other site
1170562008742	conserved gate region; other site
1170562008743	putative PBP binding loops; other site
1170562008744	ABC-ATPase subunit interface; other site
1170562008745	phosphate transporter ATP-binding protein; Provisional; Region: PRK14243
1170562008746	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1170562008747	Walker A/P-loop; other site
1170562008748	ATP binding site [chemical binding]; other site
1170562008749	Q-loop/lid; other site
1170562008750	ABC transporter signature motif; other site
1170562008751	Walker B; other site
1170562008752	D-loop; other site
1170562008753	H-loop/switch region; other site
1170562008754	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
1170562008755	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
1170562008756	NADP binding site [chemical binding]; other site
1170562008757	active site
1170562008758	putative substrate binding site [chemical binding]; other site
1170562008759	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
1170562008760	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
1170562008761	NADP-binding site; other site
1170562008762	homotetramer interface [polypeptide binding]; other site
1170562008763	substrate binding site [chemical binding]; other site
1170562008764	homodimer interface [polypeptide binding]; other site
1170562008765	active site
1170562008766	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1170562008767	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
1170562008768	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1170562008769	putative ADP-binding pocket [chemical binding]; other site
1170562008770	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1170562008771	atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265
1170562008772	putative NAD(P) binding site [chemical binding]; other site
1170562008773	active site
1170562008774	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562008775	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562008776	binding surface
1170562008777	TPR motif; other site
1170562008778	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562008779	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
1170562008780	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
1170562008781	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1170562008782	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
1170562008783	lipoyl attachment site [posttranslational modification]; other site
1170562008784	Protein of unknown function (DUF1044); Region: DUF1044; pfam06296
1170562008785	Predicted transcriptional regulator [Transcription]; Region: COG2944
1170562008786	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1170562008787	non-specific DNA binding site [nucleotide binding]; other site
1170562008788	salt bridge; other site
1170562008789	sequence-specific DNA binding site [nucleotide binding]; other site
1170562008790	glycine dehydrogenase; Provisional; Region: PRK05367
1170562008791	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1170562008792	tetramer interface [polypeptide binding]; other site
1170562008793	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1170562008794	catalytic residue [active]
1170562008795	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1170562008796	tetramer interface [polypeptide binding]; other site
1170562008797	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1170562008798	catalytic residue [active]
1170562008799	Electron transfer DM13; Region: DM13; pfam10517
1170562008800	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
1170562008801	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
1170562008802	Walker A motif; other site
1170562008803	ATP binding site [chemical binding]; other site
1170562008804	Walker B motif; other site
1170562008805	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
1170562008806	tetramer interface [polypeptide binding]; other site
1170562008807	dimer interface [polypeptide binding]; other site
1170562008808	heat shock protein 90; Provisional; Region: PRK05218
1170562008809	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562008810	ATP binding site [chemical binding]; other site
1170562008811	Mg2+ binding site [ion binding]; other site
1170562008812	G-X-G motif; other site
1170562008813	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1170562008814	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1170562008815	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1170562008816	active site
1170562008817	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1170562008818	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1170562008819	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
1170562008820	Clp amino terminal domain; Region: Clp_N; pfam02861
1170562008821	Clp amino terminal domain; Region: Clp_N; pfam02861
1170562008822	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1170562008823	Walker A motif; other site
1170562008824	ATP binding site [chemical binding]; other site
1170562008825	Walker B motif; other site
1170562008826	arginine finger; other site
1170562008827	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1170562008828	Walker A motif; other site
1170562008829	ATP binding site [chemical binding]; other site
1170562008830	Walker B motif; other site
1170562008831	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1170562008832	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1170562008833	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1170562008834	NAD(P) binding site [chemical binding]; other site
1170562008835	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
1170562008836	heme-binding site [chemical binding]; other site
1170562008837	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
1170562008838	putative catalytic site [active]
1170562008839	putative phosphate binding site [ion binding]; other site
1170562008840	active site
1170562008841	metal binding site A [ion binding]; metal-binding site
1170562008842	DNA binding site [nucleotide binding]
1170562008843	putative AP binding site [nucleotide binding]; other site
1170562008844	putative metal binding site B [ion binding]; other site
1170562008845	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
1170562008846	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1170562008847	HIGH motif; other site
1170562008848	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1170562008849	active site
1170562008850	KMSKS motif; other site
1170562008851	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1170562008852	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1170562008853	active site
1170562008854	ATP binding site [chemical binding]; other site
1170562008855	substrate binding site [chemical binding]; other site
1170562008856	activation loop (A-loop); other site
1170562008857	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1170562008858	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1170562008859	active site
1170562008860	ATP binding site [chemical binding]; other site
1170562008861	substrate binding site [chemical binding]; other site
1170562008862	activation loop (A-loop); other site
1170562008863	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1170562008864	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
1170562008865	Probable transposase; Region: OrfB_IS605; pfam01385
1170562008866	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
1170562008867	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246
1170562008868	Proteolipid membrane potential modulator; Region: Pmp3; pfam01679
1170562008869	Predicted membrane protein [Function unknown]; Region: COG1950
1170562008870	NHLM bacteriocin system ABC transporter, ATP-binding protein; Region: NHLM_micro_ABC2; TIGR03797
1170562008871	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1170562008872	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1170562008873	Walker A/P-loop; other site
1170562008874	ATP binding site [chemical binding]; other site
1170562008875	Q-loop/lid; other site
1170562008876	ABC transporter signature motif; other site
1170562008877	Walker B; other site
1170562008878	D-loop; other site
1170562008879	H-loop/switch region; other site
1170562008880	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1170562008881	non-specific DNA binding site [nucleotide binding]; other site
1170562008882	salt bridge; other site
1170562008883	sequence-specific DNA binding site [nucleotide binding]; other site
1170562008884	AAA ATPase domain; Region: AAA_16; pfam13191
1170562008885	AAA domain; Region: AAA_22; pfam13401
1170562008886	WD domain, G-beta repeat; Region: WD40; pfam00400
1170562008887	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
1170562008888	structural tetrad; other site
1170562008889	FOG: WD40 repeat [General function prediction only]; Region: COG2319
1170562008890	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
1170562008891	structural tetrad; other site
1170562008892	FOG: WD40 repeat [General function prediction only]; Region: COG2319
1170562008893	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
1170562008894	structural tetrad; other site
1170562008895	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
1170562008896	structural tetrad; other site
1170562008897	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
1170562008898	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
1170562008899	glutaminase active site [active]
1170562008900	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1170562008901	dimer interface [polypeptide binding]; other site
1170562008902	active site
1170562008903	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1170562008904	dimer interface [polypeptide binding]; other site
1170562008905	active site
1170562008906	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
1170562008907	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
1170562008908	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
1170562008909	Protein of unknown function, DUF258; Region: DUF258; pfam03193
1170562008910	FOG: WD40 repeat [General function prediction only]; Region: COG2319
1170562008911	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
1170562008912	structural tetrad; other site
1170562008913	Archaeal ATPase; Region: Arch_ATPase; pfam01637
1170562008914	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1170562008915	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
1170562008916	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
1170562008917	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
1170562008918	Walker A/P-loop; other site
1170562008919	ATP binding site [chemical binding]; other site
1170562008920	Q-loop/lid; other site
1170562008921	ABC transporter signature motif; other site
1170562008922	Walker B; other site
1170562008923	D-loop; other site
1170562008924	H-loop/switch region; other site
1170562008925	TOBE-like domain; Region: TOBE_3; pfam12857
1170562008926	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
1170562008927	Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188
1170562008928	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1170562008929	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562008930	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562008931	active site
1170562008932	phosphorylation site [posttranslational modification]
1170562008933	intermolecular recognition site; other site
1170562008934	dimerization interface [polypeptide binding]; other site
1170562008935	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562008936	ATP binding site [chemical binding]; other site
1170562008937	Mg2+ binding site [ion binding]; other site
1170562008938	G-X-G motif; other site
1170562008939	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562008940	dimer interface [polypeptide binding]; other site
1170562008941	phosphorylation site [posttranslational modification]
1170562008942	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562008943	ATP binding site [chemical binding]; other site
1170562008944	G-X-G motif; other site
1170562008945	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562008946	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562008947	active site
1170562008948	phosphorylation site [posttranslational modification]
1170562008949	intermolecular recognition site; other site
1170562008950	dimerization interface [polypeptide binding]; other site
1170562008951	acetyl-CoA synthetase; Provisional; Region: PRK00174
1170562008952	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
1170562008953	active site
1170562008954	CoA binding site [chemical binding]; other site
1170562008955	acyl-activating enzyme (AAE) consensus motif; other site
1170562008956	AMP binding site [chemical binding]; other site
1170562008957	acetate binding site [chemical binding]; other site
1170562008958	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
1170562008959	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1170562008960	threonine synthase; Reviewed; Region: PRK06721
1170562008961	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
1170562008962	homodimer interface [polypeptide binding]; other site
1170562008963	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1170562008964	catalytic residue [active]
1170562008965	Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550; cl17622
1170562008966	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
1170562008967	S-layer homology domain; Region: SLH; pfam00395
1170562008968	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
1170562008969	Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996
1170562008970	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1170562008971	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1170562008972	TM-ABC transporter signature motif; other site
1170562008973	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1170562008974	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_13; cd06348
1170562008975	putative ligand binding site [chemical binding]; other site
1170562008976	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
1170562008977	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562008978	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1170562008979	HSP70 interaction site [polypeptide binding]; other site
1170562008980	Clp protease; Region: CLP_protease; pfam00574
1170562008981	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1170562008982	oligomer interface [polypeptide binding]; other site
1170562008983	active site residues [active]
1170562008984	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
1170562008985	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1170562008986	oligomer interface [polypeptide binding]; other site
1170562008987	active site residues [active]
1170562008988	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
1170562008989	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
1170562008990	metal ion-dependent adhesion site (MIDAS); other site
1170562008991	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204
1170562008992	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
1170562008993	active site
1170562008994	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
1170562008995	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1170562008996	PYR/PP interface [polypeptide binding]; other site
1170562008997	dimer interface [polypeptide binding]; other site
1170562008998	TPP binding site [chemical binding]; other site
1170562008999	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1170562009000	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
1170562009001	TPP-binding site [chemical binding]; other site
1170562009002	Protein kinase domain; Region: Pkinase; pfam00069
1170562009003	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1170562009004	active site
1170562009005	ATP binding site [chemical binding]; other site
1170562009006	substrate binding site [chemical binding]; other site
1170562009007	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1170562009008	substrate binding site [chemical binding]; other site
1170562009009	activation loop (A-loop); other site
1170562009010	activation loop (A-loop); other site
1170562009011	AAA ATPase domain; Region: AAA_16; pfam13191
1170562009012	Predicted ATPase [General function prediction only]; Region: COG3899
1170562009013	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1170562009014	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1170562009015	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1170562009016	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562009017	ATP binding site [chemical binding]; other site
1170562009018	Mg2+ binding site [ion binding]; other site
1170562009019	G-X-G motif; other site
1170562009020	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
1170562009021	RimM N-terminal domain; Region: RimM; pfam01782
1170562009022	PRC-barrel domain; Region: PRC; pfam05239
1170562009023	valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440
1170562009024	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1170562009025	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1170562009026	homodimer interface [polypeptide binding]; other site
1170562009027	catalytic residue [active]
1170562009028	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14258
1170562009029	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1170562009030	Walker A/P-loop; other site
1170562009031	ATP binding site [chemical binding]; other site
1170562009032	Q-loop/lid; other site
1170562009033	ABC transporter signature motif; other site
1170562009034	Walker B; other site
1170562009035	D-loop; other site
1170562009036	H-loop/switch region; other site
1170562009037	PBP superfamily domain; Region: PBP_like_2; cl17296
1170562009038	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
1170562009039	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1170562009040	dimer interface [polypeptide binding]; other site
1170562009041	conserved gate region; other site
1170562009042	putative PBP binding loops; other site
1170562009043	ABC-ATPase subunit interface; other site
1170562009044	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
1170562009045	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1170562009046	dimer interface [polypeptide binding]; other site
1170562009047	conserved gate region; other site
1170562009048	putative PBP binding loops; other site
1170562009049	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1170562009050	ABC-ATPase subunit interface; other site
1170562009051	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
1170562009052	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1170562009053	Walker A/P-loop; other site
1170562009054	ATP binding site [chemical binding]; other site
1170562009055	Q-loop/lid; other site
1170562009056	ABC transporter signature motif; other site
1170562009057	Walker B; other site
1170562009058	D-loop; other site
1170562009059	H-loop/switch region; other site
1170562009060	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
1170562009061	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
1170562009062	Competence protein; Region: Competence; pfam03772
1170562009063	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
1170562009064	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
1170562009065	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
1170562009066	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
1170562009067	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
1170562009068	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1170562009069	Peptidase family M23; Region: Peptidase_M23; pfam01551
1170562009070	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
1170562009071	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1170562009072	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1170562009073	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562009074	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562009075	integral membrane protein MviN; Region: mviN; TIGR01695
1170562009076	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
1170562009077	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1170562009078	putative active site [active]
1170562009079	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1170562009080	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1170562009081	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1170562009082	heat shock protein HtpX; Provisional; Region: PRK03982
1170562009083	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
1170562009084	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
1170562009085	dimer interface [polypeptide binding]; other site
1170562009086	anticodon binding site; other site
1170562009087	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1170562009088	homodimer interface [polypeptide binding]; other site
1170562009089	motif 1; other site
1170562009090	active site
1170562009091	motif 2; other site
1170562009092	GAD domain; Region: GAD; pfam02938
1170562009093	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1170562009094	motif 3; other site
1170562009095	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
1170562009096	Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528
1170562009097	HEAT repeats; Region: HEAT_2; pfam13646
1170562009098	HEAT repeats; Region: HEAT_2; pfam13646
1170562009099	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339
1170562009100	HEAT repeats; Region: HEAT_2; pfam13646
1170562009101	HEAT repeats; Region: HEAT_2; pfam13646
1170562009102	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
1170562009103	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
1170562009104	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1170562009105	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
1170562009106	[2Fe-2S] cluster binding site [ion binding]; other site
1170562009107	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1170562009108	hydrophobic ligand binding site; other site
1170562009109	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1170562009110	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1170562009111	O-Antigen ligase; Region: Wzy_C; pfam04932
1170562009112	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
1170562009113	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
1170562009114	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1170562009115	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1170562009116	active site
1170562009117	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
1170562009118	putative ADP-binding pocket [chemical binding]; other site
1170562009119	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1170562009120	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
1170562009121	aspartate kinase; Provisional; Region: PRK07431
1170562009122	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
1170562009123	putative nucleotide binding site [chemical binding]; other site
1170562009124	putative catalytic residues [active]
1170562009125	putative Mg ion binding site [ion binding]; other site
1170562009126	putative aspartate binding site [chemical binding]; other site
1170562009127	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
1170562009128	putative allosteric regulatory site; other site
1170562009129	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
1170562009130	putative allosteric regulatory residue; other site
1170562009131	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
1170562009132	putative allosteric regulatory site; other site
1170562009133	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
1170562009134	putative allosteric regulatory residue; other site
1170562009135	NDF6 (NDH-dependent flow 6); Provisional; Region: PLN00180
1170562009136	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
1170562009137	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1170562009138	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1170562009139	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1170562009140	non-specific DNA binding site [nucleotide binding]; other site
1170562009141	salt bridge; other site
1170562009142	sequence-specific DNA binding site [nucleotide binding]; other site
1170562009143	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
1170562009144	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
1170562009145	cofactor binding site; other site
1170562009146	DNA binding site [nucleotide binding]
1170562009147	substrate interaction site [chemical binding]; other site
1170562009148	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
1170562009149	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1170562009150	non-specific DNA binding site [nucleotide binding]; other site
1170562009151	salt bridge; other site
1170562009152	sequence-specific DNA binding site [nucleotide binding]; other site
1170562009153	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1170562009154	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
1170562009155	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
1170562009156	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
1170562009157	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1170562009158	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1170562009159	G2 box; other site
1170562009160	Switch I region; other site
1170562009161	G3 box; other site
1170562009162	Switch II region; other site
1170562009163	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1170562009164	dimer interface [polypeptide binding]; other site
1170562009165	conserved gate region; other site
1170562009166	putative PBP binding loops; other site
1170562009167	ABC-ATPase subunit interface; other site
1170562009168	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1170562009169	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1170562009170	HlyD family secretion protein; Region: HlyD_3; pfam13437
1170562009171	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1170562009172	Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863
1170562009173	Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980
1170562009174	Repair protein; Region: Repair_PSII; pfam04536
1170562009175	precorrin-8X methylmutase; Validated; Region: PRK05953
1170562009176	Precorrin-8X methylmutase; Region: CbiC; pfam02570
1170562009177	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1170562009178	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1170562009179	active site
1170562009180	ATP binding site [chemical binding]; other site
1170562009181	substrate binding site [chemical binding]; other site
1170562009182	activation loop (A-loop); other site
1170562009183	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
1170562009184	FOG: WD40 repeat [General function prediction only]; Region: COG2319
1170562009185	structural tetrad; other site
1170562009186	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
1170562009187	structural tetrad; other site
1170562009188	PQQ-like domain; Region: PQQ_2; pfam13360
1170562009189	antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870
1170562009190	Zn binding site [ion binding]; other site
1170562009191	toxin interface [polypeptide binding]; other site
1170562009192	multifunctional aminopeptidase A; Provisional; Region: PRK00913
1170562009193	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
1170562009194	interface (dimer of trimers) [polypeptide binding]; other site
1170562009195	Substrate-binding/catalytic site; other site
1170562009196	Zn-binding sites [ion binding]; other site
1170562009197	Domain of unknown function (DUF3598); Region: DUF3598; pfam12204
1170562009198	FAD binding domain; Region: FAD_binding_3; pfam01494
1170562009199	hypothetical protein; Provisional; Region: PRK07236
1170562009200	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1170562009201	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1170562009202	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
1170562009203	RNA binding site [nucleotide binding]; other site
1170562009204	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
1170562009205	RNA binding site [nucleotide binding]; other site
1170562009206	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
1170562009207	RNA binding site [nucleotide binding]; other site
1170562009208	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
1170562009209	Predicted transcriptional regulators [Transcription]; Region: COG1725
1170562009210	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1170562009211	DNA-binding site [nucleotide binding]; DNA binding site
1170562009212	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
1170562009213	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
1170562009214	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
1170562009215	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1170562009216	Walker A motif; other site
1170562009217	ATP binding site [chemical binding]; other site
1170562009218	Walker B motif; other site
1170562009219	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1170562009220	Clp protease; Region: CLP_protease; pfam00574
1170562009221	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1170562009222	oligomer interface [polypeptide binding]; other site
1170562009223	active site residues [active]
1170562009224	trigger factor; Provisional; Region: tig; PRK01490
1170562009225	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1170562009226	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
1170562009227	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
1170562009228	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1170562009229	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
1170562009230	dihydrodipicolinate synthase; Region: dapA; TIGR00674
1170562009231	dimer interface [polypeptide binding]; other site
1170562009232	active site
1170562009233	catalytic residue [active]
1170562009234	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1170562009235	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
1170562009236	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1170562009237	KGK domain; Region: KGK; pfam08872
1170562009238	Uncharacterized conserved protein [Function unknown]; Region: COG1262
1170562009239	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
1170562009240	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1170562009241	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1170562009242	active site
1170562009243	ATP binding site [chemical binding]; other site
1170562009244	substrate binding site [chemical binding]; other site
1170562009245	activation loop (A-loop); other site
1170562009246	Uncharacterized conserved protein [Function unknown]; Region: COG1262
1170562009247	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
1170562009248	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
1170562009249	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
1170562009250	Ligand Binding Site [chemical binding]; other site
1170562009251	Axonemal dynein light chain; Region: Ax_dynein_light; pfam10211
1170562009252	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
1170562009253	cheY-homologous receiver domain; Region: REC; smart00448
1170562009254	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562009255	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562009256	active site
1170562009257	phosphorylation site [posttranslational modification]
1170562009258	intermolecular recognition site; other site
1170562009259	dimerization interface [polypeptide binding]; other site
1170562009260	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562009261	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562009262	active site
1170562009263	phosphorylation site [posttranslational modification]
1170562009264	intermolecular recognition site; other site
1170562009265	dimerization interface [polypeptide binding]; other site
1170562009266	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
1170562009267	TPR repeat; Region: TPR_11; pfam13414
1170562009268	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562009269	binding surface
1170562009270	TPR motif; other site
1170562009271	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1170562009272	dimerization interface [polypeptide binding]; other site
1170562009273	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1170562009274	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1170562009275	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1170562009276	dimer interface [polypeptide binding]; other site
1170562009277	putative CheW interface [polypeptide binding]; other site
1170562009278	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1170562009279	putative binding surface; other site
1170562009280	active site
1170562009281	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
1170562009282	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
1170562009283	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562009284	ATP binding site [chemical binding]; other site
1170562009285	Mg2+ binding site [ion binding]; other site
1170562009286	G-X-G motif; other site
1170562009287	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
1170562009288	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562009289	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562009290	active site
1170562009291	phosphorylation site [posttranslational modification]
1170562009292	intermolecular recognition site; other site
1170562009293	dimerization interface [polypeptide binding]; other site
1170562009294	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
1170562009295	intersubunit interface [polypeptide binding]; other site
1170562009296	active site
1170562009297	zinc binding site [ion binding]; other site
1170562009298	Na+ binding site [ion binding]; other site
1170562009299	Aldose 1-epimerase, similar to Synechocystis Slr1438; Region: Aldose_epim_Slr1438; cd09025
1170562009300	active site
1170562009301	catalytic residues [active]
1170562009302	pyruvate dehydrogenase E1 component alpha subunit; Reviewed; Region: odpA; CHL00149
1170562009303	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1170562009304	tetramer interface [polypeptide binding]; other site
1170562009305	TPP-binding site [chemical binding]; other site
1170562009306	heterodimer interface [polypeptide binding]; other site
1170562009307	phosphorylation loop region [posttranslational modification]
1170562009308	Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308
1170562009309	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
1170562009310	Zn binding site [ion binding]; other site
1170562009311	Protein of unknown function (DUF3352); Region: DUF3352; pfam11832
1170562009312	Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300
1170562009313	Cadmium resistance transporter; Region: Cad; pfam03596
1170562009314	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
1170562009315	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
1170562009316	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
1170562009317	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
1170562009318	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
1170562009319	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1170562009320	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
1170562009321	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1170562009322	classical (c) SDRs; Region: SDR_c; cd05233
1170562009323	NAD(P) binding site [chemical binding]; other site
1170562009324	active site
1170562009325	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
1170562009326	Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188
1170562009327	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1170562009328	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
1170562009329	O-Antigen ligase; Region: Wzy_C; pfam04932
1170562009330	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735
1170562009331	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1170562009332	HSP70 interaction site [polypeptide binding]; other site
1170562009333	Protein of unknown function (DUF4101); Region: DUF4101; pfam13355
1170562009334	Predicted permeases [General function prediction only]; Region: COG0679
1170562009335	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
1170562009336	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1170562009337	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1170562009338	Walker A/P-loop; other site
1170562009339	ATP binding site [chemical binding]; other site
1170562009340	Q-loop/lid; other site
1170562009341	ABC transporter signature motif; other site
1170562009342	Walker B; other site
1170562009343	D-loop; other site
1170562009344	H-loop/switch region; other site
1170562009345	Protein of unknown function (DUF3124); Region: DUF3124; pfam11322
1170562009346	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
1170562009347	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
1170562009348	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
1170562009349	MoaE homodimer interface [polypeptide binding]; other site
1170562009350	MoaD interaction [polypeptide binding]; other site
1170562009351	active site residues [active]
1170562009352	Domain of unknown function (DUF1995); Region: DUF1995; pfam09353
1170562009353	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1170562009354	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1170562009355	active site
1170562009356	metal binding site [ion binding]; metal-binding site
1170562009357	Double zinc ribbon; Region: DZR; pfam12773
1170562009358	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
1170562009359	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
1170562009360	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1170562009361	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1170562009362	phosphopeptide binding site; other site
1170562009363	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
1170562009364	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
1170562009365	putative active site [active]
1170562009366	L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590
1170562009367	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1170562009368	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1170562009369	homodimer interface [polypeptide binding]; other site
1170562009370	catalytic residue [active]
1170562009371	photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069
1170562009372	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1170562009373	RNA binding surface [nucleotide binding]; other site
1170562009374	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
1170562009375	Peptidase family M50; Region: Peptidase_M50; pfam02163
1170562009376	active site
1170562009377	putative substrate binding region [chemical binding]; other site
1170562009378	RNA polymerase sigma factor SigC; Validated; Region: PRK07598
1170562009379	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1170562009380	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1170562009381	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1170562009382	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1170562009383	DNA binding residues [nucleotide binding]
1170562009384	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK14619
1170562009385	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1170562009386	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
1170562009387	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
1170562009388	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
1170562009389	putative active site [active]
1170562009390	catalytic residue [active]
1170562009391	twin arginine translocase protein A; Provisional; Region: tatA; PRK14857
1170562009392	GTPase CgtA; Reviewed; Region: obgE; PRK12299
1170562009393	GTP1/OBG; Region: GTP1_OBG; pfam01018
1170562009394	Obg GTPase; Region: Obg; cd01898
1170562009395	G1 box; other site
1170562009396	GTP/Mg2+ binding site [chemical binding]; other site
1170562009397	Switch I region; other site
1170562009398	G2 box; other site
1170562009399	G3 box; other site
1170562009400	Switch II region; other site
1170562009401	G4 box; other site
1170562009402	G5 box; other site
1170562009403	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
1170562009404	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
1170562009405	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
1170562009406	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
1170562009407	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
1170562009408	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1170562009409	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1170562009410	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
1170562009411	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
1170562009412	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
1170562009413	active site
1170562009414	Substrate binding site; other site
1170562009415	Mg++ binding site; other site
1170562009416	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1170562009417	putative trimer interface [polypeptide binding]; other site
1170562009418	putative CoA binding site [chemical binding]; other site
1170562009419	Divergent PAP2 family; Region: DUF212; pfam02681
1170562009420	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1170562009421	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1170562009422	substrate binding pocket [chemical binding]; other site
1170562009423	chain length determination region; other site
1170562009424	substrate-Mg2+ binding site; other site
1170562009425	catalytic residues [active]
1170562009426	aspartate-rich region 1; other site
1170562009427	active site lid residues [active]
1170562009428	aspartate-rich region 2; other site
1170562009429	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14186
1170562009430	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
1170562009431	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
1170562009432	homodimer interface [polypeptide binding]; other site
1170562009433	NADP binding site [chemical binding]; other site
1170562009434	substrate binding site [chemical binding]; other site
1170562009435	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
1170562009436	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682
1170562009437	nudix motif; other site
1170562009438	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
1170562009439	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
1170562009440	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
1170562009441	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
1170562009442	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1170562009443	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
1170562009444	dimer interface [polypeptide binding]; other site
1170562009445	putative metal binding site [ion binding]; other site
1170562009446	Staphylococcal nuclease homologues; Region: SNc; smart00318
1170562009447	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
1170562009448	Catalytic site; other site
1170562009449	Pchlide_reductase_N: N protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_N; cd01979
1170562009450	light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279
1170562009451	photochlorophyllide reductase subunit L; Region: chlL; CHL00072
1170562009452	This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032
1170562009453	P-loop; other site
1170562009454	Tryptophan-rich protein (DUF2389); Region: DUF2389; pfam09493
1170562009455	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1170562009456	amidase catalytic site [active]
1170562009457	Zn binding residues [ion binding]; other site
1170562009458	substrate binding site [chemical binding]; other site
1170562009459	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1170562009460	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1170562009461	S-adenosylmethionine binding site [chemical binding]; other site
1170562009462	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1170562009463	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1170562009464	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1170562009465	active site
1170562009466	Int/Topo IB signature motif; other site
1170562009467	DNA binding site [nucleotide binding]
1170562009468	Fatty acid desaturase; Region: FA_desaturase; pfam00487
1170562009469	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
1170562009470	Di-iron ligands [ion binding]; other site
1170562009471	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
1170562009472	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
1170562009473	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1170562009474	Walker A/P-loop; other site
1170562009475	ATP binding site [chemical binding]; other site
1170562009476	Q-loop/lid; other site
1170562009477	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1170562009478	ABC transporter signature motif; other site
1170562009479	Walker B; other site
1170562009480	D-loop; other site
1170562009481	H-loop/switch region; other site
1170562009482	probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913
1170562009483	probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913
1170562009484	probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913
1170562009485	probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913
1170562009486	HAS barrel domain; Region: HAS-barrel; pfam09378
1170562009487	HerA helicase [Replication, recombination, and repair]; Region: COG0433
1170562009488	Domain of unknown function DUF87; Region: DUF87; pfam01935
1170562009489	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
1170562009490	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
1170562009491	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
1170562009492	Ligand binding site; other site
1170562009493	Putative Catalytic site; other site
1170562009494	DXD motif; other site
1170562009495	Predicted membrane protein [Function unknown]; Region: COG2246
1170562009496	GtrA-like protein; Region: GtrA; pfam04138
1170562009497	Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380
1170562009498	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1170562009499	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1170562009500	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1170562009501	binding surface
1170562009502	TPR motif; other site
1170562009503	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
1170562009504	putative active site [active]
1170562009505	Protein of unknown function (DUF2281); Region: DUF2281; cl02355
1170562009506	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
1170562009507	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
1170562009508	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
1170562009509	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
1170562009510	RNA binding site [nucleotide binding]; other site
1170562009511	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
1170562009512	feedback inhibition sensing region; other site
1170562009513	homohexameric interface [polypeptide binding]; other site
1170562009514	nucleotide binding site [chemical binding]; other site
1170562009515	N-acetyl-L-glutamate binding site [chemical binding]; other site
1170562009516	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1170562009517	Protein of unknown function (DUF3153); Region: DUF3153; pfam11353
1170562009518	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
1170562009519	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1170562009520	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1170562009521	S-layer homology domain; Region: SLH; pfam00395
1170562009522	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
1170562009523	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
1170562009524	Family description; Region: VCBS; pfam13517
1170562009525	hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470
1170562009526	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1170562009527	FeS/SAM binding site; other site
1170562009528	Domain of unknown function (DUF3463); Region: DUF3463; pfam11946
1170562009529	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562009530	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562009531	active site
1170562009532	phosphorylation site [posttranslational modification]
1170562009533	intermolecular recognition site; other site
1170562009534	dimerization interface [polypeptide binding]; other site
1170562009535	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1170562009536	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562009537	ATP binding site [chemical binding]; other site
1170562009538	Mg2+ binding site [ion binding]; other site
1170562009539	G-X-G motif; other site
1170562009540	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
1170562009541	CHASE2 domain; Region: CHASE2; pfam05226
1170562009542	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1170562009543	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562009544	dimer interface [polypeptide binding]; other site
1170562009545	phosphorylation site [posttranslational modification]
1170562009546	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562009547	ATP binding site [chemical binding]; other site
1170562009548	Mg2+ binding site [ion binding]; other site
1170562009549	G-X-G motif; other site
1170562009550	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562009551	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562009552	active site
1170562009553	phosphorylation site [posttranslational modification]
1170562009554	intermolecular recognition site; other site
1170562009555	dimerization interface [polypeptide binding]; other site
1170562009556	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
1170562009557	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562009558	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
1170562009559	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
1170562009560	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
1170562009561	Surface antigen; Region: Bac_surface_Ag; pfam01103
1170562009562	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
1170562009563	haemagglutination activity domain; Region: Haemagg_act; pfam05860
1170562009564	haemagglutination activity domain; Region: Haemagg_act; pfam05860
1170562009565	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
1170562009566	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
1170562009567	haemagglutination activity domain; Region: Haemagg_act; pfam05860
1170562009568	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
1170562009569	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
1170562009570	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
1170562009571	haemagglutination activity domain; Region: Haemagg_act; pfam05860
1170562009572	haemagglutination activity domain; Region: Haemagg_act; pfam05860
1170562009573	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
1170562009574	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1170562009575	FOG: CBS domain [General function prediction only]; Region: COG0517
1170562009576	PAS domain S-box; Region: sensory_box; TIGR00229
1170562009577	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562009578	putative active site [active]
1170562009579	heme pocket [chemical binding]; other site
1170562009580	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1170562009581	GAF domain; Region: GAF; pfam01590
1170562009582	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1170562009583	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
1170562009584	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562009585	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1170562009586	putative active site [active]
1170562009587	heme pocket [chemical binding]; other site
1170562009588	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562009589	putative active site [active]
1170562009590	heme pocket [chemical binding]; other site
1170562009591	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562009592	PAS fold; Region: PAS_3; pfam08447
1170562009593	putative active site [active]
1170562009594	heme pocket [chemical binding]; other site
1170562009595	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562009596	PAS fold; Region: PAS_3; pfam08447
1170562009597	putative active site [active]
1170562009598	heme pocket [chemical binding]; other site
1170562009599	PAS domain S-box; Region: sensory_box; TIGR00229
1170562009600	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562009601	putative active site [active]
1170562009602	heme pocket [chemical binding]; other site
1170562009603	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1170562009604	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562009605	dimer interface [polypeptide binding]; other site
1170562009606	phosphorylation site [posttranslational modification]
1170562009607	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562009608	ATP binding site [chemical binding]; other site
1170562009609	Mg2+ binding site [ion binding]; other site
1170562009610	G-X-G motif; other site
1170562009611	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1170562009612	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562009613	active site
1170562009614	phosphorylation site [posttranslational modification]
1170562009615	intermolecular recognition site; other site
1170562009616	dimerization interface [polypeptide binding]; other site
1170562009617	Cache domain; Region: Cache_1; pfam02743
1170562009618	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1170562009619	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562009620	dimer interface [polypeptide binding]; other site
1170562009621	phosphorylation site [posttranslational modification]
1170562009622	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562009623	ATP binding site [chemical binding]; other site
1170562009624	Mg2+ binding site [ion binding]; other site
1170562009625	G-X-G motif; other site
1170562009626	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1170562009627	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562009628	active site
1170562009629	phosphorylation site [posttranslational modification]
1170562009630	intermolecular recognition site; other site
1170562009631	dimerization interface [polypeptide binding]; other site
1170562009632	Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714
1170562009633	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1170562009634	active site
1170562009635	ATP binding site [chemical binding]; other site
1170562009636	substrate binding site [chemical binding]; other site
1170562009637	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1170562009638	activation loop (A-loop); other site
1170562009639	activation loop (A-loop); other site
1170562009640	AAA ATPase domain; Region: AAA_16; pfam13191
1170562009641	Predicted ATPase [General function prediction only]; Region: COG3899
1170562009642	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1170562009643	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1170562009644	PAS domain S-box; Region: sensory_box; TIGR00229
1170562009645	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562009646	putative active site [active]
1170562009647	heme pocket [chemical binding]; other site
1170562009648	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1170562009649	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562009650	dimer interface [polypeptide binding]; other site
1170562009651	phosphorylation site [posttranslational modification]
1170562009652	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562009653	ATP binding site [chemical binding]; other site
1170562009654	Mg2+ binding site [ion binding]; other site
1170562009655	G-X-G motif; other site
1170562009656	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562009657	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562009658	active site
1170562009659	phosphorylation site [posttranslational modification]
1170562009660	intermolecular recognition site; other site
1170562009661	dimerization interface [polypeptide binding]; other site
1170562009662	Protein kinase domain; Region: Pkinase; pfam00069
1170562009663	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1170562009664	active site
1170562009665	ATP binding site [chemical binding]; other site
1170562009666	substrate binding site [chemical binding]; other site
1170562009667	activation loop (A-loop); other site
1170562009668	AAA ATPase domain; Region: AAA_16; pfam13191
1170562009669	Predicted ATPase [General function prediction only]; Region: COG3899
1170562009670	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1170562009671	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1170562009672	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1170562009673	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562009674	putative active site [active]
1170562009675	heme pocket [chemical binding]; other site
1170562009676	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562009677	dimer interface [polypeptide binding]; other site
1170562009678	phosphorylation site [posttranslational modification]
1170562009679	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562009680	ATP binding site [chemical binding]; other site
1170562009681	Mg2+ binding site [ion binding]; other site
1170562009682	G-X-G motif; other site
1170562009683	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1170562009684	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562009685	active site
1170562009686	phosphorylation site [posttranslational modification]
1170562009687	intermolecular recognition site; other site
1170562009688	dimerization interface [polypeptide binding]; other site
1170562009689	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1170562009690	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1170562009691	active site
1170562009692	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1170562009693	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
1170562009694	Walker A/P-loop; other site
1170562009695	ATP binding site [chemical binding]; other site
1170562009696	Q-loop/lid; other site
1170562009697	ABC transporter signature motif; other site
1170562009698	Walker B; other site
1170562009699	D-loop; other site
1170562009700	H-loop/switch region; other site
1170562009701	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
1170562009702	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
1170562009703	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
1170562009704	Transposase IS200 like; Region: Y1_Tnp; pfam01797
1170562009705	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1170562009706	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
1170562009707	Probable transposase; Region: OrfB_IS605; pfam01385
1170562009708	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
1170562009709	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
1170562009710	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1170562009711	hypothetical protein; Provisional; Region: PRK06849
1170562009712	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
1170562009713	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
1170562009714	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1170562009715	S-adenosylmethionine binding site [chemical binding]; other site
1170562009716	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
1170562009717	active site
1170562009718	NAD binding site [chemical binding]; other site
1170562009719	metal binding site [ion binding]; metal-binding site
1170562009720	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
1170562009721	Glycoprotease family; Region: Peptidase_M22; pfam00814
1170562009722	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1170562009723	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1170562009724	active site
1170562009725	catalytic tetrad [active]
1170562009726	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1170562009727	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1170562009728	non-specific DNA binding site [nucleotide binding]; other site
1170562009729	salt bridge; other site
1170562009730	sequence-specific DNA binding site [nucleotide binding]; other site
1170562009731	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1170562009732	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
1170562009733	NodB motif; other site
1170562009734	active site
1170562009735	catalytic site [active]
1170562009736	metal binding site [ion binding]; metal-binding site
1170562009737	Protein of unknown function (DUF3370); Region: DUF3370; pfam11850
1170562009738	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
1170562009739	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
1170562009740	tRNA; other site
1170562009741	putative tRNA binding site [nucleotide binding]; other site
1170562009742	putative NADP binding site [chemical binding]; other site
1170562009743	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
1170562009744	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
1170562009745	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
1170562009746	putative active site [active]
1170562009747	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1170562009748	nucleoside/Zn binding site; other site
1170562009749	dimer interface [polypeptide binding]; other site
1170562009750	catalytic motif [active]
1170562009751	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1170562009752	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1170562009753	putative acyl-acceptor binding pocket; other site
1170562009754	Peptidase S8 family domain, uncharacterized subfamily 15; Region: Peptidases_S8_15; cd07498
1170562009755	active site
1170562009756	catalytic triad [active]
1170562009757	Proprotein convertase P-domain; Region: P_proprotein; pfam01483
1170562009758	anion exchange protein; Region: ae; TIGR00834
1170562009759	BolA-like protein; Region: BolA; pfam01722
1170562009760	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
1170562009761	putative GSH binding site [chemical binding]; other site
1170562009762	catalytic residues [active]
1170562009763	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1170562009764	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562009765	active site
1170562009766	phosphorylation site [posttranslational modification]
1170562009767	intermolecular recognition site; other site
1170562009768	dimerization interface [polypeptide binding]; other site
1170562009769	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1170562009770	DNA binding site [nucleotide binding]
1170562009771	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1170562009772	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
1170562009773	Probable transposase; Region: OrfB_IS605; pfam01385
1170562009774	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
1170562009775	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
1170562009776	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1170562009777	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
1170562009778	Uncharacterized conserved protein (DUF2358); Region: DUF2358; pfam10184
1170562009779	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
1170562009780	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
1170562009781	P loop; other site
1170562009782	Nucleotide binding site [chemical binding]; other site
1170562009783	DTAP/Switch II; other site
1170562009784	Switch I; other site
1170562009785	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
1170562009786	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1170562009787	putative active site [active]
1170562009788	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
1170562009789	rRNA interaction site [nucleotide binding]; other site
1170562009790	S8 interaction site; other site
1170562009791	putative laminin-1 binding site; other site
1170562009792	elongation factor Ts; Provisional; Region: tsf; PRK09377
1170562009793	UBA/TS-N domain; Region: UBA; pfam00627
1170562009794	Elongation factor TS; Region: EF_TS; pfam00889
1170562009795	Elongation factor TS; Region: EF_TS; pfam00889
1170562009796	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1170562009797	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
1170562009798	Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250
1170562009799	Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases; Region: CE4_PuuE_like; cd10979
1170562009800	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
1170562009801	putative active site [active]
1170562009802	putative catalytic site [active]
1170562009803	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
1170562009804	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
1170562009805	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
1170562009806	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
1170562009807	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
1170562009808	ergothioneine biosynthesis protein EgtC; Region: TIGR03442
1170562009809	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
1170562009810	putative active site [active]
1170562009811	putative dimer interface [polypeptide binding]; other site
1170562009812	Type IV pilin PilA; Region: Pilin_PilA; pfam14245
1170562009813	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1170562009814	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1170562009815	S-adenosylmethionine binding site [chemical binding]; other site
1170562009816	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1170562009817	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1170562009818	dimer interface [polypeptide binding]; other site
1170562009819	conserved gate region; other site
1170562009820	ABC-ATPase subunit interface; other site
1170562009821	Protein of unknown function (DUF2996); Region: DUF2996; pfam11210
1170562009822	Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047
1170562009823	diiron binding motif [ion binding]; other site
1170562009824	Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266
1170562009825	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562009826	binding surface
1170562009827	TPR repeat; Region: TPR_11; pfam13414
1170562009828	TPR motif; other site
1170562009829	TPR repeat; Region: TPR_11; pfam13414
1170562009830	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562009831	binding surface
1170562009832	TPR motif; other site
1170562009833	TPR repeat; Region: TPR_11; pfam13414
1170562009834	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562009835	binding surface
1170562009836	TPR motif; other site
1170562009837	TPR repeat; Region: TPR_11; pfam13414
1170562009838	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562009839	binding surface
1170562009840	TPR motif; other site
1170562009841	TPR repeat; Region: TPR_11; pfam13414
1170562009842	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
1170562009843	Lipoxygenase; Region: Lipoxygenase; pfam00305
1170562009844	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1170562009845	Cytochrome P450; Region: p450; cl12078
1170562009846	Clathrin heavy chain repeat homology; Region: CLH; smart00299
1170562009847	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
1170562009848	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
1170562009849	substrate binding site [chemical binding]; other site
1170562009850	ligand binding site [chemical binding]; other site
1170562009851	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
1170562009852	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
1170562009853	substrate binding site [chemical binding]; other site
1170562009854	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1170562009855	EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438
1170562009856	DXD motif; other site
1170562009857	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1170562009858	putative acyl transferase; Provisional; Region: PRK10191
1170562009859	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1170562009860	trimer interface [polypeptide binding]; other site
1170562009861	active site
1170562009862	substrate binding site [chemical binding]; other site
1170562009863	CoA binding site [chemical binding]; other site
1170562009864	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
1170562009865	Chain length determinant protein; Region: Wzz; pfam02706
1170562009866	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
1170562009867	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
1170562009868	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1170562009869	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
1170562009870	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
1170562009871	A bacterial subgroup of the C-type lectin-like (CTLD) domain; a subgroup of bacterial protein domains homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins; Region: CLECT_VCBS; cd03603
1170562009872	ligand binding surface [chemical binding]; other site
1170562009873	Family description; Region: VCBS; pfam13517
1170562009874	Family description; Region: VCBS; pfam13517
1170562009875	Bacterial SH3 domain homologues; Region: SH3b; smart00287
1170562009876	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1170562009877	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1170562009878	active site
1170562009879	metal binding site [ion binding]; metal-binding site
1170562009880	CTP synthetase; Validated; Region: pyrG; PRK05380
1170562009881	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
1170562009882	Catalytic site [active]
1170562009883	active site
1170562009884	UTP binding site [chemical binding]; other site
1170562009885	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
1170562009886	active site
1170562009887	putative oxyanion hole; other site
1170562009888	catalytic triad [active]
1170562009889	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
1170562009890	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1170562009891	nucleotide binding site [chemical binding]; other site
1170562009892	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
1170562009893	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1170562009894	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1170562009895	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1170562009896	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1170562009897	active site
1170562009898	metal binding site [ion binding]; metal-binding site
1170562009899	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
1170562009900	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1170562009901	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1170562009902	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
1170562009903	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
1170562009904	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
1170562009905	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
1170562009906	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
1170562009907	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
1170562009908	hinge; other site
1170562009909	active site
1170562009910	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562009911	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562009912	active site
1170562009913	phosphorylation site [posttranslational modification]
1170562009914	intermolecular recognition site; other site
1170562009915	dimerization interface [polypeptide binding]; other site
1170562009916	GAF domain; Region: GAF; pfam01590
1170562009917	GAF domain; Region: GAF_2; pfam13185
1170562009918	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562009919	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562009920	active site
1170562009921	phosphorylation site [posttranslational modification]
1170562009922	intermolecular recognition site; other site
1170562009923	dimerization interface [polypeptide binding]; other site
1170562009924	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1170562009925	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562009926	dimer interface [polypeptide binding]; other site
1170562009927	phosphorylation site [posttranslational modification]
1170562009928	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562009929	ATP binding site [chemical binding]; other site
1170562009930	Mg2+ binding site [ion binding]; other site
1170562009931	G-X-G motif; other site
1170562009932	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1170562009933	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1170562009934	dimerization interface [polypeptide binding]; other site
1170562009935	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562009936	dimer interface [polypeptide binding]; other site
1170562009937	phosphorylation site [posttranslational modification]
1170562009938	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562009939	ATP binding site [chemical binding]; other site
1170562009940	Mg2+ binding site [ion binding]; other site
1170562009941	G-X-G motif; other site
1170562009942	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562009943	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562009944	active site
1170562009945	phosphorylation site [posttranslational modification]
1170562009946	intermolecular recognition site; other site
1170562009947	dimerization interface [polypeptide binding]; other site
1170562009948	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
1170562009949	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1170562009950	membrane-bound complex binding site; other site
1170562009951	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1170562009952	putative active site [active]
1170562009953	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1170562009954	Probable transposase; Region: OrfB_IS605; pfam01385
1170562009955	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
1170562009956	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
1170562009957	Sodium Bile acid symporter family; Region: SBF; cl17470
1170562009958	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
1170562009959	Glucose inhibited division protein A; Region: GIDA; pfam01134
1170562009960	Dynamin family; Region: Dynamin_N; pfam00350
1170562009961	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
1170562009962	G1 box; other site
1170562009963	GTP/Mg2+ binding site [chemical binding]; other site
1170562009964	Switch I region; other site
1170562009965	G2 box; other site
1170562009966	Switch II region; other site
1170562009967	G3 box; other site
1170562009968	G4 box; other site
1170562009969	G5 box; other site
1170562009970	Domain of unknown function (DUF697); Region: DUF697; pfam05128
1170562009971	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1170562009972	triosephosphate isomerase; Provisional; Region: PRK14565
1170562009973	dimer interface [polypeptide binding]; other site
1170562009974	substrate binding site [chemical binding]; other site
1170562009975	catalytic triad [active]
1170562009976	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
1170562009977	dihydropteroate synthase; Region: DHPS; TIGR01496
1170562009978	substrate binding pocket [chemical binding]; other site
1170562009979	dimer interface [polypeptide binding]; other site
1170562009980	inhibitor binding site; inhibition site
1170562009981	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
1170562009982	active site
1170562009983	SAM binding site [chemical binding]; other site
1170562009984	homodimer interface [polypeptide binding]; other site
1170562009985	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
1170562009986	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
1170562009987	putative active site [active]
1170562009988	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
1170562009989	putative active site [active]
1170562009990	Uncharacterized conserved protein [Function unknown]; Region: COG0432
1170562009991	Domain of unknown function (DUF362); Region: DUF362; pfam04015
1170562009992	flavodoxin FldA; Validated; Region: PRK09267
1170562009993	chlorophyll a/b binding light-harvesting protein; Region: PS_antenn_a_b; TIGR03041
1170562009994	hypothetical protein; Provisional; Region: PRK09256
1170562009995	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
1170562009996	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562009997	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562009998	active site
1170562009999	phosphorylation site [posttranslational modification]
1170562010000	intermolecular recognition site; other site
1170562010001	dimerization interface [polypeptide binding]; other site
1170562010002	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562010003	dimer interface [polypeptide binding]; other site
1170562010004	phosphorylation site [posttranslational modification]
1170562010005	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562010006	ATP binding site [chemical binding]; other site
1170562010007	Mg2+ binding site [ion binding]; other site
1170562010008	G-X-G motif; other site
1170562010009	FOG: CBS domain [General function prediction only]; Region: COG0517
1170562010010	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_7; cd04620
1170562010011	FOG: CBS domain [General function prediction only]; Region: COG0517
1170562010012	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611
1170562010013	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1170562010014	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1170562010015	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1170562010016	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1170562010017	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1170562010018	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562010019	dimer interface [polypeptide binding]; other site
1170562010020	phosphorylation site [posttranslational modification]
1170562010021	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562010022	ATP binding site [chemical binding]; other site
1170562010023	Mg2+ binding site [ion binding]; other site
1170562010024	G-X-G motif; other site
1170562010025	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562010026	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562010027	active site
1170562010028	phosphorylation site [posttranslational modification]
1170562010029	intermolecular recognition site; other site
1170562010030	dimerization interface [polypeptide binding]; other site
1170562010031	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
1170562010032	Domain of unknown function (DUF4332); Region: DUF4332; pfam14229
1170562010033	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1170562010034	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1170562010035	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1170562010036	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1170562010037	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562010038	binding surface
1170562010039	TPR motif; other site
1170562010040	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
1170562010041	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562010042	TPR motif; other site
1170562010043	binding surface
1170562010044	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562010045	TPR motif; other site
1170562010046	binding surface
1170562010047	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562010048	binding surface
1170562010049	TPR motif; other site
1170562010050	Circadian oscillating protein COP23; Region: COP23; pfam14218
1170562010051	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1170562010052	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1170562010053	active site
1170562010054	ATP binding site [chemical binding]; other site
1170562010055	substrate binding site [chemical binding]; other site
1170562010056	activation loop (A-loop); other site
1170562010057	Domain of unknown function (DUF1795); Region: DUF1795; cl02256
1170562010058	Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862
1170562010059	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
1170562010060	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1170562010061	active site
1170562010062	ATP binding site [chemical binding]; other site
1170562010063	substrate binding site [chemical binding]; other site
1170562010064	activation loop (A-loop); other site
1170562010065	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1170562010066	phosphopeptide binding site; other site
1170562010067	NACHT domain; Region: NACHT; pfam05729
1170562010068	HEAT repeats; Region: HEAT_2; pfam13646
1170562010069	HEAT repeats; Region: HEAT_2; pfam13646
1170562010070	HEAT repeats; Region: HEAT_2; pfam13646
1170562010071	HEAT repeats; Region: HEAT_2; pfam13646
1170562010072	DNA polymerase III subunit beta; Validated; Region: PRK05643
1170562010073	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
1170562010074	putative DNA binding surface [nucleotide binding]; other site
1170562010075	dimer interface [polypeptide binding]; other site
1170562010076	beta-clamp/clamp loader binding surface; other site
1170562010077	beta-clamp/translesion DNA polymerase binding surface; other site
1170562010078	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1170562010079	RNA binding surface [nucleotide binding]; other site
1170562010080	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
1170562010081	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
1170562010082	nitrilase; Region: PLN02798
1170562010083	putative active site [active]
1170562010084	catalytic triad [active]
1170562010085	dimer interface [polypeptide binding]; other site
1170562010086	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051
1170562010087	EF-hand domain pair; Region: EF_hand_5; pfam13499
1170562010088	Ca2+ binding site [ion binding]; other site
1170562010089	Staphylococcal nuclease homologues; Region: SNc; smart00318
1170562010090	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
1170562010091	Catalytic site; other site
1170562010092	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
1170562010093	homopentamer interface [polypeptide binding]; other site
1170562010094	active site
1170562010095	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1170562010096	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
1170562010097	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1170562010098	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1170562010099	ABC-ATPase subunit  interface; other site
1170562010100	dimer interface [polypeptide binding]; other site
1170562010101	putative PBP binding regions; other site
1170562010102	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1170562010103	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1170562010104	Walker A/P-loop; other site
1170562010105	ATP binding site [chemical binding]; other site
1170562010106	Q-loop/lid; other site
1170562010107	ABC transporter signature motif; other site
1170562010108	Walker B; other site
1170562010109	D-loop; other site
1170562010110	H-loop/switch region; other site
1170562010111	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1170562010112	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1170562010113	intersubunit interface [polypeptide binding]; other site
1170562010114	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1170562010115	DNA binding residues [nucleotide binding]
1170562010116	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
1170562010117	DNA-methyltransferase (dcm); Region: dcm; TIGR00675
1170562010118	cofactor binding site; other site
1170562010119	DNA binding site [nucleotide binding]
1170562010120	substrate interaction site [chemical binding]; other site
1170562010121	Eco47II restriction endonuclease; Region: RE_Eco47II; pfam09553
1170562010122	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
1170562010123	non-specific DNA binding site [nucleotide binding]; other site
1170562010124	salt bridge; other site
1170562010125	sequence-specific DNA binding site [nucleotide binding]; other site
1170562010126	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
1170562010127	active site
1170562010128	dinuclear metal binding site [ion binding]; other site
1170562010129	dimerization interface [polypeptide binding]; other site
1170562010130	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1170562010131	Coenzyme A binding pocket [chemical binding]; other site
1170562010132	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
1170562010133	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1170562010134	active site
1170562010135	cobalamin synthase; Reviewed; Region: cobS; PRK00235
1170562010136	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
1170562010137	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
1170562010138	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
1170562010139	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1170562010140	catalytic loop [active]
1170562010141	iron binding site [ion binding]; other site
1170562010142	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1170562010143	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1170562010144	Coenzyme A binding pocket [chemical binding]; other site
1170562010145	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1170562010146	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
1170562010147	putative C-terminal domain interface [polypeptide binding]; other site
1170562010148	putative GSH binding site (G-site) [chemical binding]; other site
1170562010149	putative dimer interface [polypeptide binding]; other site
1170562010150	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
1170562010151	N-terminal domain interface [polypeptide binding]; other site
1170562010152	dimer interface [polypeptide binding]; other site
1170562010153	substrate binding pocket (H-site) [chemical binding]; other site
1170562010154	Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971
1170562010155	muropeptide transporter; Reviewed; Region: ampG; PRK11902
1170562010156	muropeptide transporter; Validated; Region: ampG; cl17669
1170562010157	photosystem II reaction center protein M; Provisional; Region: psbM; PRK04989
1170562010158	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1170562010159	Ligand Binding Site [chemical binding]; other site
1170562010160	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1170562010161	Ligand Binding Site [chemical binding]; other site
1170562010162	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
1170562010163	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
1170562010164	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1170562010165	S-adenosylmethionine binding site [chemical binding]; other site
1170562010166	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1170562010167	Probable transposase; Region: OrfB_IS605; pfam01385
1170562010168	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
1170562010169	Domain of unknown function (DUF4365); Region: DUF4365; pfam14280
1170562010170	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
1170562010171	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
1170562010172	putative active site [active]
1170562010173	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1170562010174	putative active site [active]
1170562010175	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1170562010176	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1170562010177	Coenzyme A binding pocket [chemical binding]; other site
1170562010178	XisI protein; Region: XisI; pfam08869
1170562010179	XisH protein; Region: XisH; pfam08814
1170562010180	Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907
1170562010181	Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499
1170562010182	arginine-tRNA ligase; Region: PLN02286
1170562010183	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
1170562010184	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
1170562010185	active site
1170562010186	HIGH motif; other site
1170562010187	KMSK motif region; other site
1170562010188	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
1170562010189	tRNA binding surface [nucleotide binding]; other site
1170562010190	anticodon binding site; other site
1170562010191	hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
1170562010192	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
1170562010193	Ligand binding site; other site
1170562010194	Putative Catalytic site; other site
1170562010195	DXD motif; other site
1170562010196	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
1170562010197	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
1170562010198	Active site cavity [active]
1170562010199	catalytic acid [active]
1170562010200	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1170562010201	S-adenosylmethionine binding site [chemical binding]; other site
1170562010202	Phytoene/squalene synthetase [Lipid metabolism]; Region: ERG9; COG1562
1170562010203	substrate binding pocket [chemical binding]; other site
1170562010204	substrate-Mg2+ binding site; other site
1170562010205	aspartate-rich region 1; other site
1170562010206	aspartate-rich region 2; other site
1170562010207	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562010208	binding surface
1170562010209	TPR motif; other site
1170562010210	TPR repeat; Region: TPR_11; pfam13414
1170562010211	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562010212	binding surface
1170562010213	TPR motif; other site
1170562010214	TPR repeat; Region: TPR_11; pfam13414
1170562010215	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562010216	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562010217	binding surface
1170562010218	TPR motif; other site
1170562010219	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
1170562010220	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
1170562010221	catalytic site [active]
1170562010222	putative active site [active]
1170562010223	putative substrate binding site [chemical binding]; other site
1170562010224	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
1170562010225	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
1170562010226	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562010227	TPR motif; other site
1170562010228	binding surface
1170562010229	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562010230	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562010231	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562010232	binding surface
1170562010233	TPR motif; other site
1170562010234	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562010235	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562010236	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562010237	TPR motif; other site
1170562010238	binding surface
1170562010239	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562010240	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562010241	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562010242	binding surface
1170562010243	TPR motif; other site
1170562010244	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562010245	binding surface
1170562010246	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562010247	TPR motif; other site
1170562010248	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562010249	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562010250	CHAT domain; Region: CHAT; pfam12770
1170562010251	dihydrodipicolinate reductase; Provisional; Region: PRK00048
1170562010252	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
1170562010253	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
1170562010254	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14333
1170562010255	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1170562010256	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1170562010257	FeS/SAM binding site; other site
1170562010258	TRAM domain; Region: TRAM; pfam01938
1170562010259	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
1170562010260	Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852
1170562010261	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1170562010262	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1170562010263	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
1170562010264	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1170562010265	acyl-activating enzyme (AAE) consensus motif; other site
1170562010266	Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444
1170562010267	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1170562010268	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
1170562010269	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
1170562010270	Protein of unknown function (DUF3574); Region: DUF3574; pfam12098
1170562010271	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1170562010272	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1170562010273	active site
1170562010274	ATP binding site [chemical binding]; other site
1170562010275	substrate binding site [chemical binding]; other site
1170562010276	activation loop (A-loop); other site
1170562010277	Predicted nucleotidyltransferase [General function prediction only]; Region: COG3541
1170562010278	ribosomal protein L21; Region: rpl21; CHL00075
1170562010279	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
1170562010280	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
1170562010281	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
1170562010282	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1170562010283	Zn2+ binding site [ion binding]; other site
1170562010284	Mg2+ binding site [ion binding]; other site
1170562010285	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
1170562010286	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
1170562010287	Dehydroquinase class II; Region: DHquinase_II; pfam01220
1170562010288	trimer interface [polypeptide binding]; other site
1170562010289	active site
1170562010290	dimer interface [polypeptide binding]; other site
1170562010291	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
1170562010292	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
1170562010293	active site
1170562010294	interdomain interaction site; other site
1170562010295	putative metal-binding site [ion binding]; other site
1170562010296	nucleotide binding site [chemical binding]; other site
1170562010297	Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436
1170562010298	domain I; other site
1170562010299	phosphate binding site [ion binding]; other site
1170562010300	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1170562010301	domain II; other site
1170562010302	domain III; other site
1170562010303	nucleotide binding site [chemical binding]; other site
1170562010304	DNA binding groove [nucleotide binding]
1170562010305	catalytic site [active]
1170562010306	domain IV; other site
1170562010307	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
1170562010308	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
1170562010309	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
1170562010310	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
1170562010311	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
1170562010312	NAD(P)H-quinone oxidoreductase subunit 2; Provisional; Region: PRK02504
1170562010313	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1170562010314	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1170562010315	Sel1-like repeats; Region: SEL1; smart00671
1170562010316	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
1170562010317	urease subunit alpha; Reviewed; Region: ureC; PRK13207
1170562010318	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
1170562010319	subunit interactions [polypeptide binding]; other site
1170562010320	active site
1170562010321	flap region; other site
1170562010322	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
1170562010323	Uncharacterized conserved protein [Function unknown]; Region: COG0397
1170562010324	hypothetical protein; Validated; Region: PRK00029
1170562010325	AAA ATPase domain; Region: AAA_16; pfam13191
1170562010326	WD domain, G-beta repeat; Region: WD40; pfam00400
1170562010327	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
1170562010328	FOG: WD40 repeat [General function prediction only]; Region: COG2319
1170562010329	structural tetrad; other site
1170562010330	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
1170562010331	structural tetrad; other site
1170562010332	FOG: WD40 repeat [General function prediction only]; Region: COG2319
1170562010333	WD40 repeats; Region: WD40; smart00320
1170562010334	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
1170562010335	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
1170562010336	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
1170562010337	cell division protein FtsZ; Validated; Region: PRK09330
1170562010338	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
1170562010339	nucleotide binding site [chemical binding]; other site
1170562010340	SulA interaction site; other site
1170562010341	glutathione synthetase; Provisional; Region: PRK05246
1170562010342	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
1170562010343	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
1170562010344	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
1170562010345	GSH binding site [chemical binding]; other site
1170562010346	catalytic residues [active]
1170562010347	Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702
1170562010348	acetylornithine aminotransferase; Provisional; Region: PRK02627
1170562010349	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1170562010350	inhibitor-cofactor binding pocket; inhibition site
1170562010351	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1170562010352	catalytic residue [active]
1170562010353	GTP-binding protein YchF; Reviewed; Region: PRK09601
1170562010354	YchF GTPase; Region: YchF; cd01900
1170562010355	G1 box; other site
1170562010356	GTP/Mg2+ binding site [chemical binding]; other site
1170562010357	Switch I region; other site
1170562010358	G2 box; other site
1170562010359	Switch II region; other site
1170562010360	G3 box; other site
1170562010361	G4 box; other site
1170562010362	G5 box; other site
1170562010363	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
1170562010364	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
1170562010365	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
1170562010366	NAD(P) binding site [chemical binding]; other site
1170562010367	catalytic residues [active]
1170562010368	acetolactate synthase; Reviewed; Region: PRK08322
1170562010369	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1170562010370	PYR/PP interface [polypeptide binding]; other site
1170562010371	dimer interface [polypeptide binding]; other site
1170562010372	TPP binding site [chemical binding]; other site
1170562010373	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1170562010374	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
1170562010375	TPP-binding site [chemical binding]; other site
1170562010376	dimer interface [polypeptide binding]; other site
1170562010377	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
1170562010378	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562010379	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562010380	Uncharacterized protein containing caspase domain [General function prediction only]; Region: COG4249
1170562010381	Caspase domain; Region: Peptidase_C14; pfam00656
1170562010382	GUN4-like; Region: GUN4; pfam05419
1170562010383	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1170562010384	dimerization interface [polypeptide binding]; other site
1170562010385	putative DNA binding site [nucleotide binding]; other site
1170562010386	putative Zn2+ binding site [ion binding]; other site
1170562010387	Endoribonuclease XendoU; Region: XendoU; pfam09412
1170562010388	Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436
1170562010389	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1170562010390	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1170562010391	HlyD family secretion protein; Region: HlyD_3; pfam13437
1170562010392	AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873
1170562010393	Protein export membrane protein; Region: SecD_SecF; cl14618
1170562010394	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
1170562010395	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
1170562010396	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
1170562010397	substrate binding pocket [chemical binding]; other site
1170562010398	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
1170562010399	B12 binding site [chemical binding]; other site
1170562010400	cobalt ligand [ion binding]; other site
1170562010401	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
1170562010402	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
1170562010403	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
1170562010404	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
1170562010405	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1170562010406	putative active site [active]
1170562010407	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: HicB; COG4226
1170562010408	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
1170562010409	HicB family; Region: HicB; pfam05534
1170562010410	2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK07364
1170562010411	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1170562010412	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1170562010413	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1170562010414	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1170562010415	catalytic residue [active]
1170562010416	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
1170562010417	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
1170562010418	nucleotide binding site [chemical binding]; other site
1170562010419	NEF interaction site [polypeptide binding]; other site
1170562010420	SBD interface [polypeptide binding]; other site
1170562010421	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
1170562010422	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
1170562010423	homoserine kinase; Provisional; Region: PRK01212
1170562010424	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1170562010425	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
1170562010426	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1170562010427	NAD binding site [chemical binding]; other site
1170562010428	catalytic Zn binding site [ion binding]; other site
1170562010429	structural Zn binding site [ion binding]; other site
1170562010430	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
1170562010431	putative hydrophobic ligand binding site [chemical binding]; other site
1170562010432	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1170562010433	active site
1170562010434	catalytic tetrad [active]
1170562010435	Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to...; Region: TUDOR; cl02573
1170562010436	RNA binding activity-knot of a chromodomain; Region: Tudor-knot; pfam11717
1170562010437	NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561
1170562010438	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1170562010439	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
1170562010440	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
1170562010441	ligand binding site [chemical binding]; other site
1170562010442	NAD binding site [chemical binding]; other site
1170562010443	dimerization interface [polypeptide binding]; other site
1170562010444	catalytic site [active]
1170562010445	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
1170562010446	putative L-serine binding site [chemical binding]; other site
1170562010447	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
1170562010448	thiS-thiF/thiG interaction site; other site
1170562010449	thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615
1170562010450	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1170562010451	thiamine phosphate binding site [chemical binding]; other site
1170562010452	active site
1170562010453	pyrophosphate binding site [ion binding]; other site
1170562010454	Protein of unknown function (DUF1565); Region: DUF1565; pfam07602
1170562010455	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1170562010456	TIR domain; Region: TIR_2; pfam13676
1170562010457	Domain of unknown function (DUF1802); Region: DUF1802; pfam08819
1170562010458	Nuclease A inhibitor-like protein; Region: NuiA; pfam07924
1170562010459	Nuclease A inhibitor-like protein; Region: NuiA; pfam07924
1170562010460	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
1170562010461	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
1170562010462	putative active site [active]
1170562010463	substrate binding site [chemical binding]; other site
1170562010464	putative cosubstrate binding site; other site
1170562010465	catalytic site [active]
1170562010466	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
1170562010467	substrate binding site [chemical binding]; other site
1170562010468	Protein kinase domain; Region: Pkinase; pfam00069
1170562010469	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1170562010470	active site
1170562010471	ATP binding site [chemical binding]; other site
1170562010472	substrate binding site [chemical binding]; other site
1170562010473	activation loop (A-loop); other site
1170562010474	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1170562010475	active site
1170562010476	ATP binding site [chemical binding]; other site
1170562010477	substrate binding site [chemical binding]; other site
1170562010478	activation loop (A-loop); other site
1170562010479	cell division topological specificity factor MinE; Provisional; Region: PRK13988
1170562010480	septum site-determining protein MinD; Region: minD_bact; TIGR01968
1170562010481	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
1170562010482	Switch I; other site
1170562010483	Switch II; other site
1170562010484	septum formation inhibitor; Reviewed; Region: minC; PRK00513
1170562010485	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
1170562010486	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
1170562010487	Translation initiation factor 6 (eIF-6) [Translation, ribosomal structure and biogenesis]; Region: TIF6; COG1976
1170562010488	MEKHLA domain; Region: MEKHLA; pfam08670
1170562010489	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
1170562010490	oligomeric interface; other site
1170562010491	putative active site [active]
1170562010492	homodimer interface [polypeptide binding]; other site
1170562010493	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
1170562010494	homoserine dehydrogenase; Provisional; Region: PRK06349
1170562010495	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1170562010496	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
1170562010497	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
1170562010498	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
1170562010499	ferredoxin--NADP+ reductase; Provisional; Region: PLN03116
1170562010500	These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208
1170562010501	dimerization interface [polypeptide binding]; other site
1170562010502	FAD binding pocket [chemical binding]; other site
1170562010503	FAD binding motif [chemical binding]; other site
1170562010504	catalytic residues [active]
1170562010505	NAD binding pocket [chemical binding]; other site
1170562010506	phosphate binding motif [ion binding]; other site
1170562010507	beta-alpha-beta structure motif; other site
1170562010508	phosphoribulokinase; Provisional; Region: PRK07429
1170562010509	Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026
1170562010510	active site
1170562010511	S-adenosylmethionine synthetase; Validated; Region: PRK05250
1170562010512	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
1170562010513	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
1170562010514	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
1170562010515	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1170562010516	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1170562010517	dimerization interface [polypeptide binding]; other site
1170562010518	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562010519	dimer interface [polypeptide binding]; other site
1170562010520	phosphorylation site [posttranslational modification]
1170562010521	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562010522	ATP binding site [chemical binding]; other site
1170562010523	Mg2+ binding site [ion binding]; other site
1170562010524	G-X-G motif; other site
1170562010525	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
1170562010526	Part of AAA domain; Region: AAA_19; pfam13245
1170562010527	Family description; Region: UvrD_C_2; pfam13538
1170562010528	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1170562010529	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562010530	dimer interface [polypeptide binding]; other site
1170562010531	phosphorylation site [posttranslational modification]
1170562010532	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562010533	ATP binding site [chemical binding]; other site
1170562010534	Mg2+ binding site [ion binding]; other site
1170562010535	G-X-G motif; other site
1170562010536	Uncharacterized conserved protein [Function unknown]; Region: COG3287
1170562010537	FIST N domain; Region: FIST; pfam08495
1170562010538	FIST C domain; Region: FIST_C; pfam10442
1170562010539	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1170562010540	BT1 family; Region: BT1; pfam03092
1170562010541	putative substrate translocation pore; other site
1170562010542	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
1170562010543	Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055
1170562010544	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1170562010545	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562010546	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562010547	haemagglutination activity domain; Region: Haemagg_act; pfam05860
1170562010548	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
1170562010549	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1170562010550	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1170562010551	active site
1170562010552	ATP binding site [chemical binding]; other site
1170562010553	substrate binding site [chemical binding]; other site
1170562010554	activation loop (A-loop); other site
1170562010555	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
1170562010556	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
1170562010557	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
1170562010558	putative dimer interface [polypeptide binding]; other site
1170562010559	N-terminal domain interface [polypeptide binding]; other site
1170562010560	putative substrate binding pocket (H-site) [chemical binding]; other site
1170562010561	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1170562010562	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1170562010563	Glutathione S-transferase, C-terminal domain; Region: GST_C; pfam00043
1170562010564	N-terminal domain interface [polypeptide binding]; other site
1170562010565	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
1170562010566	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
1170562010567	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
1170562010568	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649
1170562010569	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1170562010570	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1170562010571	active site
1170562010572	ATP binding site [chemical binding]; other site
1170562010573	substrate binding site [chemical binding]; other site
1170562010574	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1170562010575	substrate binding site [chemical binding]; other site
1170562010576	activation loop (A-loop); other site
1170562010577	activation loop (A-loop); other site
1170562010578	AAA ATPase domain; Region: AAA_16; pfam13191
1170562010579	Predicted ATPase [General function prediction only]; Region: COG3899
1170562010580	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1170562010581	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1170562010582	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562010583	PAS fold; Region: PAS_3; pfam08447
1170562010584	putative active site [active]
1170562010585	heme pocket [chemical binding]; other site
1170562010586	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1170562010587	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562010588	ATP binding site [chemical binding]; other site
1170562010589	Mg2+ binding site [ion binding]; other site
1170562010590	G-X-G motif; other site
1170562010591	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1170562010592	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1170562010593	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
1170562010594	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1170562010595	HlyD family secretion protein; Region: HlyD_3; pfam13437
1170562010596	Protein of unknown function (DUF2834); Region: DUF2834; pfam11196
1170562010597	DevC protein; Region: devC; TIGR01185
1170562010598	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1170562010599	FtsX-like permease family; Region: FtsX; pfam02687
1170562010600	ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982
1170562010601	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1170562010602	Walker A/P-loop; other site
1170562010603	ATP binding site [chemical binding]; other site
1170562010604	Q-loop/lid; other site
1170562010605	ABC transporter signature motif; other site
1170562010606	Walker B; other site
1170562010607	D-loop; other site
1170562010608	H-loop/switch region; other site
1170562010609	Family description; Region: VCBS; pfam13517
1170562010610	Family description; Region: VCBS; pfam13517
1170562010611	Family description; Region: VCBS; pfam13517
1170562010612	Family description; Region: VCBS; pfam13517
1170562010613	Family description; Region: VCBS; pfam13517
1170562010614	Family description; Region: VCBS; pfam13517
1170562010615	Family description; Region: VCBS; pfam13517
1170562010616	Family description; Region: VCBS; pfam13517
1170562010617	Family description; Region: VCBS; pfam13517
1170562010618	Family description; Region: VCBS; pfam13517
1170562010619	Family description; Region: VCBS; pfam13517
1170562010620	FOG: WD40 repeat [General function prediction only]; Region: COG2319
1170562010621	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
1170562010622	structural tetrad; other site
1170562010623	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1170562010624	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1170562010625	S-adenosylmethionine binding site [chemical binding]; other site
1170562010626	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562010627	binding surface
1170562010628	TPR motif; other site
1170562010629	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562010630	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562010631	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562010632	binding surface
1170562010633	TPR motif; other site
1170562010634	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562010635	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562010636	binding surface
1170562010637	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562010638	TPR motif; other site
1170562010639	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562010640	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
1170562010641	Protein of unknown function (DUF3225); Region: DUF3225; pfam11533
1170562010642	KTSC domain; Region: KTSC; pfam13619
1170562010643	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
1170562010644	Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180
1170562010645	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
1170562010646	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
1170562010647	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1170562010648	S-adenosylmethionine binding site [chemical binding]; other site
1170562010649	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
1170562010650	catalytic motif [active]
1170562010651	Catalytic residue [active]
1170562010652	KWG Leptospira; Region: KWG; pfam07656
1170562010653	VWA ORF176 type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ORF176_type; cd01457
1170562010654	metal ion-dependent adhesion site (MIDAS); other site
1170562010655	VWA ORF176 type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ORF176_type; cd01457
1170562010656	metal ion-dependent adhesion site (MIDAS); other site
1170562010657	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1170562010658	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426
1170562010659	folate binding site [chemical binding]; other site
1170562010660	NADP+ binding site [chemical binding]; other site
1170562010661	2TM domain; Region: 2TM; pfam13239
1170562010662	Protein of unknown function (DUF2949); Region: DUF2949; pfam11165
1170562010663	Creatinine amidohydrolase; Region: Creatininase; pfam02633
1170562010664	D-allose kinase; Provisional; Region: PRK09698
1170562010665	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1170562010666	nucleotide binding site [chemical binding]; other site
1170562010667	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
1170562010668	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
1170562010669	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
1170562010670	CHASE3 domain; Region: CHASE3; pfam05227
1170562010671	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1170562010672	dimerization interface [polypeptide binding]; other site
1170562010673	GAF domain; Region: GAF_2; pfam13185
1170562010674	GAF domain; Region: GAF; pfam01590
1170562010675	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1170562010676	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
1170562010677	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562010678	ATP binding site [chemical binding]; other site
1170562010679	Mg2+ binding site [ion binding]; other site
1170562010680	G-X-G motif; other site
1170562010681	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562010682	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562010683	active site
1170562010684	phosphorylation site [posttranslational modification]
1170562010685	intermolecular recognition site; other site
1170562010686	dimerization interface [polypeptide binding]; other site
1170562010687	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562010688	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562010689	active site
1170562010690	phosphorylation site [posttranslational modification]
1170562010691	intermolecular recognition site; other site
1170562010692	dimerization interface [polypeptide binding]; other site
1170562010693	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562010694	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562010695	active site
1170562010696	phosphorylation site [posttranslational modification]
1170562010697	intermolecular recognition site; other site
1170562010698	dimerization interface [polypeptide binding]; other site
1170562010699	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1170562010700	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1170562010701	active site
1170562010702	metal binding site [ion binding]; metal-binding site
1170562010703	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
1170562010704	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1170562010705	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1170562010706	HEAT-like repeat; Region: HEAT_EZ; pfam13513
1170562010707	HEAT repeats; Region: HEAT_2; pfam13646
1170562010708	magnesium chelatase subunit H; Provisional; Region: PLN03241
1170562010709	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
1170562010710	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
1170562010711	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948
1170562010712	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1170562010713	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1170562010714	dimer interface [polypeptide binding]; other site
1170562010715	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1170562010716	catalytic residue [active]
1170562010717	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1170562010718	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
1170562010719	Probable transposase; Region: OrfB_IS605; pfam01385
1170562010720	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
1170562010721	Uncharacterized conserved protein [Function unknown]; Region: COG1432
1170562010722	LabA_like proteins; Region: LabA; cd10911
1170562010723	putative metal binding site [ion binding]; other site
1170562010724	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1170562010725	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1170562010726	ABC-ATPase subunit  interface; other site
1170562010727	dimer interface [polypeptide binding]; other site
1170562010728	putative PBP binding regions; other site
1170562010729	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1170562010730	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1170562010731	Walker A/P-loop; other site
1170562010732	ATP binding site [chemical binding]; other site
1170562010733	Q-loop/lid; other site
1170562010734	ABC transporter signature motif; other site
1170562010735	Walker B; other site
1170562010736	D-loop; other site
1170562010737	H-loop/switch region; other site
1170562010738	AMIN domain; Region: AMIN; pfam11741
1170562010739	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
1170562010740	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1170562010741	N-terminal plug; other site
1170562010742	ligand-binding site [chemical binding]; other site
1170562010743	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1170562010744	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1170562010745	intersubunit interface [polypeptide binding]; other site
1170562010746	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1170562010747	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1170562010748	G1 box; other site
1170562010749	GTP/Mg2+ binding site [chemical binding]; other site
1170562010750	G2 box; other site
1170562010751	Switch I region; other site
1170562010752	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
1170562010753	putative active site [active]
1170562010754	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1170562010755	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1170562010756	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1170562010757	motif II; other site
1170562010758	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
1170562010759	putative active site [active]
1170562010760	transaldolase; Provisional; Region: PRK03903
1170562010761	catalytic residue [active]
1170562010762	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
1170562010763	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
1170562010764	dimer interface [polypeptide binding]; other site
1170562010765	PYR/PP interface [polypeptide binding]; other site
1170562010766	TPP binding site [chemical binding]; other site
1170562010767	substrate binding site [chemical binding]; other site
1170562010768	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
1170562010769	Domain of unknown function; Region: EKR; pfam10371
1170562010770	4Fe-4S binding domain; Region: Fer4_6; pfam12837
1170562010771	4Fe-4S binding domain; Region: Fer4; pfam00037
1170562010772	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
1170562010773	TPP-binding site [chemical binding]; other site
1170562010774	dimer interface [polypeptide binding]; other site
1170562010775	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4719
1170562010776	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1170562010777	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
1170562010778	Right handed beta helix region; Region: Beta_helix; pfam13229
1170562010779	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1170562010780	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1170562010781	ligand binding site [chemical binding]; other site
1170562010782	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1170562010783	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
1170562010784	Double zinc ribbon; Region: DZR; pfam12773
1170562010785	Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115
1170562010786	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1170562010787	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1170562010788	phosphopeptide binding site; other site
1170562010789	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1170562010790	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1170562010791	metal-binding site [ion binding]
1170562010792	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1170562010793	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1170562010794	motif II; other site
1170562010795	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
1170562010796	CHAT domain; Region: CHAT; cl17868
1170562010797	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
1170562010798	CHASE2 domain; Region: CHASE2; pfam05226
1170562010799	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
1170562010800	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1170562010801	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1170562010802	active site
1170562010803	hypothetical protein; Validated; Region: PRK00153
1170562010804	GTPase Era; Reviewed; Region: era; PRK00089
1170562010805	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
1170562010806	G1 box; other site
1170562010807	GTP/Mg2+ binding site [chemical binding]; other site
1170562010808	Switch I region; other site
1170562010809	G2 box; other site
1170562010810	Switch II region; other site
1170562010811	G3 box; other site
1170562010812	G4 box; other site
1170562010813	G5 box; other site
1170562010814	Iron-sulfur cluster assembly accessory protein; Region: TIGR00049
1170562010815	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1170562010816	binding surface
1170562010817	TPR motif; other site
1170562010818	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
1170562010819	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
1170562010820	putative NAD(P) binding site [chemical binding]; other site
1170562010821	putative active site [active]
1170562010822	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
1170562010823	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
1170562010824	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
1170562010825	HlyD family secretion protein; Region: HlyD_3; pfam13437
1170562010826	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
1170562010827	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1170562010828	Coenzyme A binding pocket [chemical binding]; other site
1170562010829	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1170562010830	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1170562010831	Walker A/P-loop; other site
1170562010832	ATP binding site [chemical binding]; other site
1170562010833	Q-loop/lid; other site
1170562010834	ABC transporter signature motif; other site
1170562010835	Walker B; other site
1170562010836	D-loop; other site
1170562010837	H-loop/switch region; other site
1170562010838	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1170562010839	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1170562010840	FtsX-like permease family; Region: FtsX; pfam02687
1170562010841	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1170562010842	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1170562010843	HlyD family secretion protein; Region: HlyD_3; pfam13437
1170562010844	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1170562010845	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1170562010846	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1170562010847	catalytic residue [active]
1170562010848	TPR repeat; Region: TPR_11; pfam13414
1170562010849	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562010850	binding surface
1170562010851	TPR motif; other site
1170562010852	TPR repeat; Region: TPR_11; pfam13414
1170562010853	Uncharacterized conserved protein [Function unknown]; Region: COG0393
1170562010854	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
1170562010855	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
1170562010856	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299
1170562010857	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
1170562010858	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1170562010859	catalytic triad [active]
1170562010860	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1170562010861	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1170562010862	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
1170562010863	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1170562010864	methionine sulfoxide reductase B; Provisional; Region: PRK00222
1170562010865	SelR domain; Region: SelR; pfam01641
1170562010866	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
1170562010867	Cytochrome P450; Region: p450; cl12078
1170562010868	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1170562010869	Homo sapiens acid phosphatase 5 and related proteins, metallophosphatase domain; Region: MPP_ACP5; cd07378
1170562010870	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1170562010871	active site
1170562010872	metal binding site [ion binding]; metal-binding site
1170562010873	Predicted protease of the Abi (CAAX) family [General function prediction only]; Region: COG4449
1170562010874	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
1170562010875	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1170562010876	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1170562010877	ligand binding site [chemical binding]; other site
1170562010878	flexible hinge region; other site
1170562010879	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
1170562010880	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259
1170562010881	putative active site [active]
1170562010882	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1170562010883	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1170562010884	Walker A/P-loop; other site
1170562010885	ATP binding site [chemical binding]; other site
1170562010886	Q-loop/lid; other site
1170562010887	ABC transporter signature motif; other site
1170562010888	Walker B; other site
1170562010889	D-loop; other site
1170562010890	H-loop/switch region; other site
1170562010891	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
1170562010892	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1170562010893	HlyD family secretion protein; Region: HlyD_3; pfam13437
1170562010894	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
1170562010895	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1170562010896	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1170562010897	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1170562010898	active site
1170562010899	ATP binding site [chemical binding]; other site
1170562010900	substrate binding site [chemical binding]; other site
1170562010901	activation loop (A-loop); other site
1170562010902	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
1170562010903	isocitrate dehydrogenase; Validated; Region: PRK07362
1170562010904	GUN4-like; Region: GUN4; pfam05419
1170562010905	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
1170562010906	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1170562010907	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
1170562010908	Probable transposase; Region: OrfB_IS605; pfam01385
1170562010909	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
1170562010910	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
1170562010911	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1170562010912	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1170562010913	Peptidase family M23; Region: Peptidase_M23; pfam01551
1170562010914	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
1170562010915	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1170562010916	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1170562010917	dimerization interface [polypeptide binding]; other site
1170562010918	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
1170562010919	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1170562010920	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1170562010921	rRNA small subunit methyltransferase G; Region: GidB; pfam02527
1170562010922	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1170562010923	S-adenosylmethionine binding site [chemical binding]; other site
1170562010924	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1170562010925	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562010926	active site
1170562010927	phosphorylation site [posttranslational modification]
1170562010928	intermolecular recognition site; other site
1170562010929	dimerization interface [polypeptide binding]; other site
1170562010930	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1170562010931	DNA binding residues [nucleotide binding]
1170562010932	dimerization interface [polypeptide binding]; other site
1170562010933	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
1170562010934	FAD binding domain; Region: FAD_binding_4; pfam01565
1170562010935	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
1170562010936	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
1170562010937	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1170562010938	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1170562010939	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1170562010940	glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK07403
1170562010941	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
1170562010942	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1170562010943	thiamine monophosphate kinase; Provisional; Region: PRK05731
1170562010944	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
1170562010945	ATP binding site [chemical binding]; other site
1170562010946	dimerization interface [polypeptide binding]; other site
1170562010947	cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924
1170562010948	active site
1170562010949	phycocyanin, alpha subunit; Region: phycocy_alpha; TIGR01338
1170562010950	phycocyanin, beta subunit; Region: phycocy_beta; TIGR01339
1170562010951	Ferredoxin-dependent bilin reductase; Region: Fe_bilin_red; cl07930
1170562010952	dihydrobiliverdin:ferredoxin oxidoreductase; Provisional; Region: PRK13247
1170562010953	CpeS-like protein; Region: CpeS; pfam09367
1170562010954	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1170562010955	Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483
1170562010956	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
1170562010957	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1170562010958	glutamine binding [chemical binding]; other site
1170562010959	catalytic triad [active]
1170562010960	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
1170562010961	metal-binding heat shock protein; Provisional; Region: PRK00016
1170562010962	Protein of unknown function (DUF3285); Region: DUF3285; pfam11688
1170562010963	peptide chain release factor 2; Validated; Region: prfB; PRK00578
1170562010964	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1170562010965	RF-1 domain; Region: RF-1; pfam00472
1170562010966	RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408
1170562010967	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1170562010968	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1170562010969	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
1170562010970	DNA binding residues [nucleotide binding]
1170562010971	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1170562010972	putative active site [active]
1170562010973	tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Region: TIGR00057
1170562010974	hypothetical protein; Provisional; Region: PRK04194
1170562010975	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
1170562010976	NADH dehydrogenase transmembrane subunit; Region: NdhL; pfam10716
1170562010977	Protein of unknown function (DUF3007); Region: DUF3007; pfam11460
1170562010978	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
1170562010979	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
1170562010980	substrate binding site [chemical binding]; other site
1170562010981	active site
1170562010982	catalytic residues [active]
1170562010983	heterodimer interface [polypeptide binding]; other site
1170562010984	conserved repeat domain; Region: B_ant_repeat; TIGR01451
1170562010985	Right handed beta helix region; Region: Beta_helix; pfam13229
1170562010986	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1170562010987	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1170562010988	ligand binding site [chemical binding]; other site
1170562010989	Cna protein B-type domain; Region: Cna_B; pfam05738
1170562010990	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1170562010991	Domain of unknown function DUF11; Region: DUF11; cl17728
1170562010992	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1170562010993	putative active site [active]
1170562010994	NPCBM/NEW2 domain; Region: NPCBM; cl07060
1170562010995	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
1170562010996	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
1170562010997	homotetramer interface [polypeptide binding]; other site
1170562010998	ligand binding site [chemical binding]; other site
1170562010999	catalytic site [active]
1170562011000	NAD binding site [chemical binding]; other site
1170562011001	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864
1170562011002	PemK-like protein; Region: PemK; pfam02452
1170562011003	Uncharacterized conserved protein [Function unknown]; Region: COG5464
1170562011004	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
1170562011005	Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402
1170562011006	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
1170562011007	active site
1170562011008	putative substrate binding pocket [chemical binding]; other site
1170562011009	Isochorismatase family; Region: Isochorismatase; pfam00857
1170562011010	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1170562011011	catalytic triad [active]
1170562011012	conserved cis-peptide bond; other site
1170562011013	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
1170562011014	Phosphate acyltransferases; Region: PlsC; smart00563
1170562011015	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1170562011016	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
1170562011017	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1170562011018	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
1170562011019	substrate binding site [chemical binding]; other site
1170562011020	active site
1170562011021	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1170562011022	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
1170562011023	NAD(P) binding site [chemical binding]; other site
1170562011024	active site
1170562011025	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
1170562011026	hypothetical protein; Reviewed; Region: PRK00024
1170562011027	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
1170562011028	MPN+ (JAMM) motif; other site
1170562011029	Zinc-binding site [ion binding]; other site
1170562011030	Uncharacterized conserved protein [Function unknown]; Region: COG3287
1170562011031	FIST N domain; Region: FIST; pfam08495
1170562011032	FIST C domain; Region: FIST_C; pfam10442
1170562011033	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1170562011034	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
1170562011035	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562011036	ATP binding site [chemical binding]; other site
1170562011037	Mg2+ binding site [ion binding]; other site
1170562011038	G-X-G motif; other site
1170562011039	Cytochrome c; Region: Cytochrom_C; cl11414
1170562011040	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1170562011041	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
1170562011042	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1170562011043	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1170562011044	protein binding site [polypeptide binding]; other site
1170562011045	arogenate dehydrogenase; Reviewed; Region: PRK07417
1170562011046	prephenate dehydrogenase; Validated; Region: PRK08507
1170562011047	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
1170562011048	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562011049	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562011050	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562011051	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562011052	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562011053	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562011054	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1170562011055	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
1170562011056	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1170562011057	catalytic loop [active]
1170562011058	iron binding site [ion binding]; other site
1170562011059	Staphylococcal nuclease homologues; Region: SNc; smart00318
1170562011060	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
1170562011061	Catalytic site; other site
1170562011062	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1170562011063	Permease; Region: Permease; pfam02405
1170562011064	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1170562011065	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1170562011066	S-adenosylmethionine binding site [chemical binding]; other site
1170562011067	ferrochelatase; Reviewed; Region: hemH; PRK00035
1170562011068	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
1170562011069	C-terminal domain interface [polypeptide binding]; other site
1170562011070	active site
1170562011071	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
1170562011072	active site
1170562011073	N-terminal domain interface [polypeptide binding]; other site
1170562011074	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1170562011075	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1170562011076	active site
1170562011077	ATP binding site [chemical binding]; other site
1170562011078	substrate binding site [chemical binding]; other site
1170562011079	activation loop (A-loop); other site
1170562011080	Protein of unknown function (DUF4101); Region: DUF4101; pfam13355
1170562011081	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
1170562011082	Protein of unknown function (DUF1565); Region: DUF1565; pfam07602
1170562011083	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
1170562011084	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
1170562011085	S-layer homology domain; Region: SLH; pfam00395
1170562011086	S-layer homology domain; Region: SLH; pfam00395
1170562011087	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562011088	dimer interface [polypeptide binding]; other site
1170562011089	phosphorylation site [posttranslational modification]
1170562011090	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562011091	ATP binding site [chemical binding]; other site
1170562011092	G-X-G motif; other site
1170562011093	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562011094	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562011095	active site
1170562011096	phosphorylation site [posttranslational modification]
1170562011097	intermolecular recognition site; other site
1170562011098	dimerization interface [polypeptide binding]; other site
1170562011099	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562011100	putative active site [active]
1170562011101	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
1170562011102	PAS domain S-box; Region: sensory_box; TIGR00229
1170562011103	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562011104	putative active site [active]
1170562011105	heme pocket [chemical binding]; other site
1170562011106	PAS domain; Region: PAS; smart00091
1170562011107	PAS domain; Region: PAS_9; pfam13426
1170562011108	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562011109	putative active site [active]
1170562011110	heme pocket [chemical binding]; other site
1170562011111	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1170562011112	GAF domain; Region: GAF; pfam01590
1170562011113	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1170562011114	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1170562011115	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562011116	dimer interface [polypeptide binding]; other site
1170562011117	phosphorylation site [posttranslational modification]
1170562011118	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562011119	ATP binding site [chemical binding]; other site
1170562011120	Mg2+ binding site [ion binding]; other site
1170562011121	G-X-G motif; other site
1170562011122	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1170562011123	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562011124	active site
1170562011125	phosphorylation site [posttranslational modification]
1170562011126	intermolecular recognition site; other site
1170562011127	dimerization interface [polypeptide binding]; other site
1170562011128	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562011129	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562011130	active site
1170562011131	phosphorylation site [posttranslational modification]
1170562011132	intermolecular recognition site; other site
1170562011133	dimerization interface [polypeptide binding]; other site
1170562011134	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1170562011135	putative binding surface; other site
1170562011136	active site
1170562011137	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
1170562011138	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
1170562011139	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1170562011140	anti sigma factor interaction site; other site
1170562011141	regulatory phosphorylation site [posttranslational modification]; other site
1170562011142	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562011143	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562011144	active site
1170562011145	phosphorylation site [posttranslational modification]
1170562011146	intermolecular recognition site; other site
1170562011147	dimerization interface [polypeptide binding]; other site
1170562011148	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
1170562011149	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
1170562011150	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1170562011151	GAF domain; Region: GAF; pfam01590
1170562011152	CHASE3 domain; Region: CHASE3; pfam05227
1170562011153	PAS domain S-box; Region: sensory_box; TIGR00229
1170562011154	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562011155	putative active site [active]
1170562011156	heme pocket [chemical binding]; other site
1170562011157	GAF domain; Region: GAF_2; pfam13185
1170562011158	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1170562011159	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
1170562011160	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1170562011161	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562011162	dimer interface [polypeptide binding]; other site
1170562011163	phosphorylation site [posttranslational modification]
1170562011164	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562011165	ATP binding site [chemical binding]; other site
1170562011166	Mg2+ binding site [ion binding]; other site
1170562011167	G-X-G motif; other site
1170562011168	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562011169	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562011170	active site
1170562011171	phosphorylation site [posttranslational modification]
1170562011172	intermolecular recognition site; other site
1170562011173	dimerization interface [polypeptide binding]; other site
1170562011174	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562011175	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562011176	active site
1170562011177	phosphorylation site [posttranslational modification]
1170562011178	intermolecular recognition site; other site
1170562011179	dimerization interface [polypeptide binding]; other site
1170562011180	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1170562011181	putative binding surface; other site
1170562011182	active site
1170562011183	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1170562011184	active site
1170562011185	metal binding site [ion binding]; metal-binding site
1170562011186	Double-stranded DNA-binding domain; Region: dsDNA_bind; cl00928
1170562011187	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1170562011188	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1170562011189	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1170562011190	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
1170562011191	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
1170562011192	homodecamer interface [polypeptide binding]; other site
1170562011193	GTP cyclohydrolase I; Provisional; Region: PLN03044
1170562011194	active site
1170562011195	putative catalytic site residues [active]
1170562011196	zinc binding site [ion binding]; other site
1170562011197	GTP-CH-I/GFRP interaction surface; other site
1170562011198	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562011199	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1170562011200	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562011201	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1170562011202	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562011203	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562011204	S-layer homology domain; Region: SLH; pfam00395
1170562011205	S-layer homology domain; Region: SLH; pfam00395
1170562011206	S-layer homology domain; Region: SLH; pfam00395
1170562011207	Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242
1170562011208	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
1170562011209	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1170562011210	putative binding surface; other site
1170562011211	active site
1170562011212	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
1170562011213	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562011214	ATP binding site [chemical binding]; other site
1170562011215	Mg2+ binding site [ion binding]; other site
1170562011216	G-X-G motif; other site
1170562011217	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
1170562011218	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562011219	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562011220	active site
1170562011221	phosphorylation site [posttranslational modification]
1170562011222	intermolecular recognition site; other site
1170562011223	dimerization interface [polypeptide binding]; other site
1170562011224	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1170562011225	dimerization interface [polypeptide binding]; other site
1170562011226	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1170562011227	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1170562011228	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1170562011229	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1170562011230	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1170562011231	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1170562011232	dimer interface [polypeptide binding]; other site
1170562011233	putative CheW interface [polypeptide binding]; other site
1170562011234	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562011235	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562011236	active site
1170562011237	phosphorylation site [posttranslational modification]
1170562011238	intermolecular recognition site; other site
1170562011239	dimerization interface [polypeptide binding]; other site
1170562011240	signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705
1170562011241	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
1170562011242	tandem repeat interface [polypeptide binding]; other site
1170562011243	oligomer interface [polypeptide binding]; other site
1170562011244	active site residues [active]
1170562011245	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
1170562011246	tandem repeat interface [polypeptide binding]; other site
1170562011247	oligomer interface [polypeptide binding]; other site
1170562011248	active site residues [active]
1170562011249	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
1170562011250	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
1170562011251	homotetramer interface [polypeptide binding]; other site
1170562011252	FMN binding site [chemical binding]; other site
1170562011253	homodimer contacts [polypeptide binding]; other site
1170562011254	putative active site [active]
1170562011255	putative substrate binding site [chemical binding]; other site
1170562011256	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562011257	putative active site [active]
1170562011258	nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938
1170562011259	heme pocket [chemical binding]; other site
1170562011260	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562011261	putative active site [active]
1170562011262	heme pocket [chemical binding]; other site
1170562011263	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562011264	dimer interface [polypeptide binding]; other site
1170562011265	phosphorylation site [posttranslational modification]
1170562011266	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562011267	ATP binding site [chemical binding]; other site
1170562011268	Mg2+ binding site [ion binding]; other site
1170562011269	G-X-G motif; other site
1170562011270	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG3694
1170562011271	ferredoxin-sulfite reductase; Region: sir; TIGR02042
1170562011272	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1170562011273	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1170562011274	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
1170562011275	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1170562011276	Transposase domain (DUF772); Region: DUF772; pfam05598
1170562011277	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1170562011278	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
1170562011279	Clp protease ATP binding subunit; Region: clpC; CHL00095
1170562011280	Clp amino terminal domain; Region: Clp_N; pfam02861
1170562011281	Clp amino terminal domain; Region: Clp_N; pfam02861
1170562011282	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1170562011283	Walker A motif; other site
1170562011284	ATP binding site [chemical binding]; other site
1170562011285	Walker B motif; other site
1170562011286	arginine finger; other site
1170562011287	UvrB/uvrC motif; Region: UVR; pfam02151
1170562011288	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1170562011289	Walker A motif; other site
1170562011290	ATP binding site [chemical binding]; other site
1170562011291	Walker B motif; other site
1170562011292	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1170562011293	Protein of unknown function (DUF3288); Region: DUF3288; pfam11691
1170562011294	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1170562011295	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1170562011296	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562011297	binding surface
1170562011298	TPR motif; other site
1170562011299	TPR repeat; Region: TPR_11; pfam13414
1170562011300	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562011301	binding surface
1170562011302	TPR motif; other site
1170562011303	TPR repeat; Region: TPR_11; pfam13414
1170562011304	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562011305	binding surface
1170562011306	TPR motif; other site
1170562011307	HicB family; Region: HicB; pfam05534
1170562011308	PIN domain; Region: PIN_3; pfam13470
1170562011309	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
1170562011310	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
1170562011311	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
1170562011312	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
1170562011313	putative active site [active]
1170562011314	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
1170562011315	putative active site [active]
1170562011316	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
1170562011317	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562011318	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562011319	sialate_O-acetylesterase_like subfamily of the SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: sialate_O-acetylesterase_like2; cd01828
1170562011320	active site
1170562011321	catalytic triad [active]
1170562011322	oxyanion hole [active]
1170562011323	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Provisional; Region: PRK13371
1170562011324	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
1170562011325	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
1170562011326	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
1170562011327	NAD binding site [chemical binding]; other site
1170562011328	homodimer interface [polypeptide binding]; other site
1170562011329	active site
1170562011330	substrate binding site [chemical binding]; other site
1170562011331	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
1170562011332	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1170562011333	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1170562011334	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
1170562011335	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1170562011336	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1170562011337	homodimer interface [polypeptide binding]; other site
1170562011338	catalytic residue [active]
1170562011339	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1170562011340	IHF dimer interface [polypeptide binding]; other site
1170562011341	IHF - DNA interface [nucleotide binding]; other site
1170562011342	Protein of unknown function (DUF3616); Region: DUF3616; pfam12275
1170562011343	Uncharacterized conserved protein [Function unknown]; Region: COG5607
1170562011344	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
1170562011345	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562011346	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562011347	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562011348	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562011349	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562011350	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562011351	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1170562011352	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562011353	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562011354	Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276
1170562011355	Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276
1170562011356	active site
1170562011357	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
1170562011358	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1170562011359	motif II; other site
1170562011360	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1170562011361	putative active site [active]
1170562011362	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1170562011363	putative active site [active]
1170562011364	dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280
1170562011365	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
1170562011366	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
1170562011367	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
1170562011368	Ligand Binding Site [chemical binding]; other site
1170562011369	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249
1170562011370	dimerization interface [polypeptide binding]; other site
1170562011371	putative active cleft [active]
1170562011372	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1170562011373	DNA-binding site [nucleotide binding]; DNA binding site
1170562011374	RNA-binding motif; other site
1170562011375	Protein of unknown function (DUF1294); Region: DUF1294; pfam06961
1170562011376	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1170562011377	catalytic core [active]
1170562011378	glucokinase; Provisional; Region: glk; PRK00292
1170562011379	glucokinase, proteobacterial type; Region: glk; TIGR00749
1170562011380	ribosomal protein S4; Reviewed; Region: rps4; CHL00113
1170562011381	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
1170562011382	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1170562011383	RNA binding surface [nucleotide binding]; other site
1170562011384	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
1170562011385	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1170562011386	FeS/SAM binding site; other site
1170562011387	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
1170562011388	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1170562011389	cell division protein; Validated; Region: ftsH; CHL00176
1170562011390	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1170562011391	Walker A motif; other site
1170562011392	ATP binding site [chemical binding]; other site
1170562011393	Walker B motif; other site
1170562011394	arginine finger; other site
1170562011395	Peptidase family M41; Region: Peptidase_M41; pfam01434
1170562011396	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
1170562011397	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
1170562011398	putative ligand binding site [chemical binding]; other site
1170562011399	putative NAD binding site [chemical binding]; other site
1170562011400	catalytic site [active]
1170562011401	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1170562011402	Peptidase family M23; Region: Peptidase_M23; pfam01551
1170562011403	Domain of unknown function (DUF4112); Region: DUF4112; pfam13430
1170562011404	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1170562011405	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
1170562011406	CHASE2 domain; Region: CHASE2; pfam05226
1170562011407	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1170562011408	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562011409	dimer interface [polypeptide binding]; other site
1170562011410	phosphorylation site [posttranslational modification]
1170562011411	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562011412	ATP binding site [chemical binding]; other site
1170562011413	Mg2+ binding site [ion binding]; other site
1170562011414	G-X-G motif; other site
1170562011415	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1170562011416	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562011417	active site
1170562011418	phosphorylation site [posttranslational modification]
1170562011419	intermolecular recognition site; other site
1170562011420	dimerization interface [polypeptide binding]; other site
1170562011421	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
1170562011422	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562011423	binding surface
1170562011424	TPR motif; other site
1170562011425	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562011426	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562011427	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
1170562011428	haemagglutination activity domain; Region: Haemagg_act; pfam05860
1170562011429	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1170562011430	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1170562011431	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1170562011432	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
1170562011433	putative ADP-binding pocket [chemical binding]; other site
1170562011434	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1170562011435	HEAT repeats; Region: HEAT_2; pfam13646
1170562011436	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
1170562011437	EamA-like transporter family; Region: EamA; pfam00892
1170562011438	EamA-like transporter family; Region: EamA; pfam00892
1170562011439	Protein kinase domain; Region: Pkinase; pfam00069
1170562011440	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1170562011441	active site
1170562011442	ATP binding site [chemical binding]; other site
1170562011443	substrate binding site [chemical binding]; other site
1170562011444	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1170562011445	substrate binding site [chemical binding]; other site
1170562011446	activation loop (A-loop); other site
1170562011447	activation loop (A-loop); other site
1170562011448	AAA ATPase domain; Region: AAA_16; pfam13191
1170562011449	Predicted ATPase [General function prediction only]; Region: COG3899
1170562011450	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1170562011451	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1170562011452	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1170562011453	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562011454	ATP binding site [chemical binding]; other site
1170562011455	Mg2+ binding site [ion binding]; other site
1170562011456	G-X-G motif; other site
1170562011457	DDE superfamily endonuclease; Region: DDE_5; cl17874
1170562011458	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1170562011459	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562011460	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562011461	active site
1170562011462	phosphorylation site [posttranslational modification]
1170562011463	intermolecular recognition site; other site
1170562011464	dimerization interface [polypeptide binding]; other site
1170562011465	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1170562011466	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
1170562011467	dimer interface [polypeptide binding]; other site
1170562011468	phosphorylation site [posttranslational modification]
1170562011469	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562011470	ATP binding site [chemical binding]; other site
1170562011471	Mg2+ binding site [ion binding]; other site
1170562011472	G-X-G motif; other site
1170562011473	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1170562011474	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1170562011475	active site
1170562011476	ATP binding site [chemical binding]; other site
1170562011477	substrate binding site [chemical binding]; other site
1170562011478	activation loop (A-loop); other site
1170562011479	AAA ATPase domain; Region: AAA_16; pfam13191
1170562011480	Predicted ATPase [General function prediction only]; Region: COG3899
1170562011481	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1170562011482	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1170562011483	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1170562011484	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562011485	ATP binding site [chemical binding]; other site
1170562011486	Mg2+ binding site [ion binding]; other site
1170562011487	G-X-G motif; other site
1170562011488	CCC1-related family of proteins; Region: CCC1_like; cl00278
1170562011489	AAA ATPase domain; Region: AAA_16; pfam13191
1170562011490	NACHT domain; Region: NACHT; pfam05729
1170562011491	GUN4-like; Region: GUN4; pfam05419
1170562011492	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
1170562011493	active site
1170562011494	metal binding site [ion binding]; metal-binding site
1170562011495	interdomain interaction site; other site
1170562011496	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1170562011497	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1170562011498	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1170562011499	dimer interface [polypeptide binding]; other site
1170562011500	conserved gate region; other site
1170562011501	putative PBP binding loops; other site
1170562011502	ABC-ATPase subunit interface; other site
1170562011503	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562011504	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562011505	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1170562011506	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562011507	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562011508	cellulose synthase-interactive protein; Provisional; Region: PLN03200
1170562011509	Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454
1170562011510	Pirin; Region: Pirin; pfam02678
1170562011511	Pirin-related protein [General function prediction only]; Region: COG1741
1170562011512	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
1170562011513	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1170562011514	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1170562011515	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
1170562011516	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
1170562011517	hexamer interface [polypeptide binding]; other site
1170562011518	ligand binding site [chemical binding]; other site
1170562011519	putative active site [active]
1170562011520	NAD(P) binding site [chemical binding]; other site
1170562011521	light-harvesting-like protein 3; Provisional; Region: PLN00014
1170562011522	FOG: WD40 repeat [General function prediction only]; Region: COG2319
1170562011523	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
1170562011524	structural tetrad; other site
1170562011525	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
1170562011526	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
1170562011527	Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525
1170562011528	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
1170562011529	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
1170562011530	Subunit I/III interface [polypeptide binding]; other site
1170562011531	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
1170562011532	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
1170562011533	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
1170562011534	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
1170562011535	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
1170562011536	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
1170562011537	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
1170562011538	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
1170562011539	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
1170562011540	UbiA prenyltransferase family; Region: UbiA; pfam01040
1170562011541	Peptidase S8 family domain in CspA-like proteins; Region: Peptidases_S8_CspA-like; cd07478
1170562011542	active site
1170562011543	catalytic triad [active]
1170562011544	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
1170562011545	ATP-dependent Clp protease adaptor; Reviewed; Region: clpS; PRK13019
1170562011546	Predicted metal-binding protein (DUF2103); Region: DUF2103; cl01651
1170562011547	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1170562011548	Tic20-like protein; Region: Tic20; pfam09685
1170562011549	2-isopropylmalate synthase; Validated; Region: PRK00915
1170562011550	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
1170562011551	active site
1170562011552	catalytic residues [active]
1170562011553	metal binding site [ion binding]; metal-binding site
1170562011554	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
1170562011555	Uncharacterized conserved protein [Function unknown]; Region: COG1432
1170562011556	LabA_like proteins; Region: LabA; cd10911
1170562011557	putative metal binding site [ion binding]; other site
1170562011558	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
1170562011559	CHASE2 domain; Region: CHASE2; pfam05226
1170562011560	Protein kinase domain; Region: Pkinase; pfam00069
1170562011561	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1170562011562	active site
1170562011563	ATP binding site [chemical binding]; other site
1170562011564	substrate binding site [chemical binding]; other site
1170562011565	activation loop (A-loop); other site
1170562011566	FecR protein; Region: FecR; pfam04773
1170562011567	FecR protein; Region: FecR; pfam04773
1170562011568	cytochrome c-550; Provisional; Region: psbV; cl17239
1170562011569	Dihaem cytochrome c; Region: DHC; pfam09626
1170562011570	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12902
1170562011571	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1170562011572	ATP binding site [chemical binding]; other site
1170562011573	putative Mg++ binding site [ion binding]; other site
1170562011574	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
1170562011575	Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG4551
1170562011576	active site
1170562011577	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
1170562011578	amphipathic channel; other site
1170562011579	Asn-Pro-Ala signature motifs; other site
1170562011580	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
1170562011581	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1170562011582	active site
1170562011583	motif I; other site
1170562011584	motif II; other site
1170562011585	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1170562011586	CP12 domain; Region: CP12; pfam02672
1170562011587	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1170562011588	S-adenosylmethionine binding site [chemical binding]; other site
1170562011589	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
1170562011590	nucleotide binding site/active site [active]
1170562011591	HIT family signature motif; other site
1170562011592	catalytic residue [active]
1170562011593	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1170562011594	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1170562011595	MoxR-like ATPases [General function prediction only]; Region: COG0714
1170562011596	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1170562011597	Walker A motif; other site
1170562011598	ATP binding site [chemical binding]; other site
1170562011599	Walker B motif; other site
1170562011600	arginine finger; other site
1170562011601	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
1170562011602	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
1170562011603	active site
1170562011604	Riboflavin kinase; Region: Flavokinase; pfam01687
1170562011605	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
1170562011606	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
1170562011607	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
1170562011608	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
1170562011609	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
1170562011610	dimer interface [polypeptide binding]; other site
1170562011611	motif 1; other site
1170562011612	active site
1170562011613	motif 2; other site
1170562011614	motif 3; other site
1170562011615	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
1170562011616	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1170562011617	ATP binding site [chemical binding]; other site
1170562011618	putative Mg++ binding site [ion binding]; other site
1170562011619	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1170562011620	nucleotide binding region [chemical binding]; other site
1170562011621	ATP-binding site [chemical binding]; other site
1170562011622	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
1170562011623	MPT binding site; other site
1170562011624	trimer interface [polypeptide binding]; other site
1170562011625	Psb28 protein; Region: Psb28; cl04326
1170562011626	Protein of unknown function (DUF3531); Region: DUF3531; pfam12049
1170562011627	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688
1170562011628	nudix motif; other site
1170562011629	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1170562011630	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1170562011631	active site
1170562011632	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
1170562011633	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
1170562011634	ribonuclease Z; Region: RNase_Z; TIGR02651
1170562011635	isoleucyl-tRNA synthetase; Region: PLN02843
1170562011636	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1170562011637	HIGH motif; other site
1170562011638	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1170562011639	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1170562011640	active site
1170562011641	KMSKS motif; other site
1170562011642	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
1170562011643	tRNA binding surface [nucleotide binding]; other site
1170562011644	anticodon binding site; other site
1170562011645	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1170562011646	Uncharacterized conserved protein [Function unknown]; Region: COG5464
1170562011647	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
1170562011648	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1170562011649	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1170562011650	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
1170562011651	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
1170562011652	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1170562011653	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1170562011654	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
1170562011655	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
1170562011656	putative homodimer interface [polypeptide binding]; other site
1170562011657	putative active site pocket [active]
1170562011658	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
1170562011659	glycogen synthase; Provisional; Region: glgA; PRK00654
1170562011660	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
1170562011661	ADP-binding pocket [chemical binding]; other site
1170562011662	homodimer interface [polypeptide binding]; other site
1170562011663	Protein of unknown function (DUF1361); Region: DUF1361; cl01784
1170562011664	Protein of unknown function (DUF1361); Region: DUF1361; cl01784
1170562011665	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
1170562011666	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
1170562011667	G1 box; other site
1170562011668	GTP/Mg2+ binding site [chemical binding]; other site
1170562011669	Switch I region; other site
1170562011670	G2 box; other site
1170562011671	Switch II region; other site
1170562011672	G3 box; other site
1170562011673	G4 box; other site
1170562011674	G5 box; other site
1170562011675	Domain of unknown function (DUF697); Region: DUF697; pfam05128
1170562011676	1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515
1170562011677	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
1170562011678	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1170562011679	catalytic residue [active]
1170562011680	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1170562011681	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
1170562011682	active site
1170562011683	motif I; other site
1170562011684	motif II; other site
1170562011685	FtsH Extracellular; Region: FtsH_ext; pfam06480
1170562011686	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
1170562011687	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1170562011688	Walker A motif; other site
1170562011689	ATP binding site [chemical binding]; other site
1170562011690	Walker B motif; other site
1170562011691	arginine finger; other site
1170562011692	Peptidase family M41; Region: Peptidase_M41; pfam01434
1170562011693	2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886
1170562011694	Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045
1170562011695	Predicted transcriptional regulator [Transcription]; Region: COG3682
1170562011696	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
1170562011697	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1170562011698	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562011699	active site
1170562011700	phosphorylation site [posttranslational modification]
1170562011701	intermolecular recognition site; other site
1170562011702	dimerization interface [polypeptide binding]; other site
1170562011703	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1170562011704	DNA binding site [nucleotide binding]
1170562011705	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1170562011706	catalytic core [active]
1170562011707	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1170562011708	catalytic core [active]
1170562011709	dihydroorotase; Provisional; Region: PRK07369
1170562011710	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
1170562011711	active site
1170562011712	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
1170562011713	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
1170562011714	Surface antigen; Region: Bac_surface_Ag; pfam01103
1170562011715	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1170562011716	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1170562011717	dimer interface [polypeptide binding]; other site
1170562011718	conserved gate region; other site
1170562011719	putative PBP binding loops; other site
1170562011720	ABC-ATPase subunit interface; other site
1170562011721	Protein of unknown function (DUF1565); Region: DUF1565; pfam07602
1170562011722	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
1170562011723	S-layer homology domain; Region: SLH; pfam00395
1170562011724	S-layer homology domain; Region: SLH; pfam00395
1170562011725	S-layer homology domain; Region: SLH; pfam00395
1170562011726	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
1170562011727	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
1170562011728	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1170562011729	catalytic residues [active]
1170562011730	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1170562011731	S-adenosylmethionine binding site [chemical binding]; other site
1170562011732	Thiol-disulfide isomerase and thioredoxins [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: TrxA; COG0526
1170562011733	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1170562011734	MarR family; Region: MarR_2; pfam12802
1170562011735	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1170562011736	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1170562011737	S-adenosylmethionine binding site [chemical binding]; other site
1170562011738	RNA polymerase sigma factor; Provisional; Region: PRK12519
1170562011739	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1170562011740	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1170562011741	DNA binding residues [nucleotide binding]
1170562011742	putative anti-sigmaE protein; Provisional; Region: PRK13920
1170562011743	Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553
1170562011744	Uncharacterized conserved protein [Function unknown]; Region: COG3391
1170562011745	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1170562011746	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1170562011747	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1170562011748	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1170562011749	active site
1170562011750	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1170562011751	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1170562011752	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
1170562011753	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
1170562011754	trmE is a tRNA modification GTPase; Region: trmE; cd04164
1170562011755	G1 box; other site
1170562011756	GTP/Mg2+ binding site [chemical binding]; other site
1170562011757	Switch I region; other site
1170562011758	G2 box; other site
1170562011759	Switch II region; other site
1170562011760	G3 box; other site
1170562011761	G4 box; other site
1170562011762	G5 box; other site
1170562011763	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
1170562011764	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
1170562011765	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
1170562011766	tetramerization interface [polypeptide binding]; other site
1170562011767	active site
1170562011768	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
1170562011769	dimer interface [polypeptide binding]; other site
1170562011770	substrate binding site [chemical binding]; other site
1170562011771	metal binding sites [ion binding]; metal-binding site
1170562011772	Uncharacterized conserved protein [Function unknown]; Region: COG2006
1170562011773	Domain of unknown function (DUF362); Region: DUF362; pfam04015
1170562011774	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
1170562011775	Aspartase; Region: Aspartase; cd01357
1170562011776	active sites [active]
1170562011777	tetramer interface [polypeptide binding]; other site
1170562011778	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1170562011779	S-adenosylmethionine binding site [chemical binding]; other site
1170562011780	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820
1170562011781	putative hydrophobic ligand binding site [chemical binding]; other site
1170562011782	putative glycosyl transferase; Provisional; Region: PRK10307
1170562011783	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
1170562011784	OstA-like protein; Region: OstA; cl00844
1170562011785	Protein of unknown function (DUF3769); Region: DUF3769; pfam12600
1170562011786	photosystem II reaction center I protein I; Provisional; Region: psbI; PRK02655
1170562011787	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
1170562011788	NAD(P)H-quinone oxidoreductase subunit H; Validated; Region: PRK07415
1170562011789	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
1170562011790	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1170562011791	S-adenosylmethionine binding site [chemical binding]; other site
1170562011792	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1170562011793	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1170562011794	active site
1170562011795	ATP binding site [chemical binding]; other site
1170562011796	substrate binding site [chemical binding]; other site
1170562011797	activation loop (A-loop); other site
1170562011798	Protein kinase domain; Region: Pkinase; pfam00069
1170562011799	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1170562011800	active site
1170562011801	ATP binding site [chemical binding]; other site
1170562011802	substrate binding site [chemical binding]; other site
1170562011803	activation loop (A-loop); other site
1170562011804	biotin synthase; Region: bioB; TIGR00433
1170562011805	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1170562011806	FeS/SAM binding site; other site
1170562011807	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
1170562011808	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1170562011809	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1170562011810	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
1170562011811	tartrate dehydrogenase; Region: TTC; TIGR02089
1170562011812	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
1170562011813	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
1170562011814	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
1170562011815	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
1170562011816	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1170562011817	Bacterial SH3 domain; Region: SH3_3; pfam08239
1170562011818	Caspase domain; Region: Peptidase_C14; pfam00656
1170562011819	sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149
1170562011820	ATP-sulfurylase; Region: ATPS; cd00517
1170562011821	active site
1170562011822	HXXH motif; other site
1170562011823	flexible loop; other site
1170562011824	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
1170562011825	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
1170562011826	B12 binding site [chemical binding]; other site
1170562011827	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1170562011828	FeS/SAM binding site; other site
1170562011829	Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255
1170562011830	Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540
1170562011831	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
1170562011832	putative active site [active]
1170562011833	putative metal binding site [ion binding]; other site
1170562011834	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
1170562011835	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
1170562011836	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1170562011837	inhibitor-cofactor binding pocket; inhibition site
1170562011838	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1170562011839	catalytic residue [active]
1170562011840	Protein of unknown function (DUF561); Region: DUF561; pfam04481
1170562011841	Serine endopeptidase inhibitors; Region: Inhibitor_I10; pfam12559
1170562011842	ATP-grasp ribosomal peptide maturase, MvdD family; Region: ATPgraspMvdD; TIGR04184
1170562011843	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1170562011844	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562011845	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1170562011846	putative active site [active]
1170562011847	heme pocket [chemical binding]; other site
1170562011848	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562011849	dimer interface [polypeptide binding]; other site
1170562011850	phosphorylation site [posttranslational modification]
1170562011851	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562011852	ATP binding site [chemical binding]; other site
1170562011853	Mg2+ binding site [ion binding]; other site
1170562011854	G-X-G motif; other site
1170562011855	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
1170562011856	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
1170562011857	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1170562011858	S-adenosylmethionine binding site [chemical binding]; other site
1170562011859	PAS fold; Region: PAS; pfam00989
1170562011860	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562011861	putative active site [active]
1170562011862	heme pocket [chemical binding]; other site
1170562011863	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562011864	PAS domain; Region: PAS_9; pfam13426
1170562011865	putative active site [active]
1170562011866	heme pocket [chemical binding]; other site
1170562011867	Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201
1170562011868	CheB methylesterase; Region: CheB_methylest; pfam01339
1170562011869	Protein of unknown function DUF262; Region: DUF262; pfam03235
1170562011870	geranylgeranyl reductase; Region: ChlP; TIGR02028
1170562011871	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1170562011872	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1170562011873	photosystem I assembly protein Ycf3; Provisional; Region: PRK02603
1170562011874	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562011875	binding surface
1170562011876	TPR motif; other site
1170562011877	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1170562011878	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
1170562011879	putative C-terminal domain interface [polypeptide binding]; other site
1170562011880	putative GSH binding site (G-site) [chemical binding]; other site
1170562011881	putative dimer interface [polypeptide binding]; other site
1170562011882	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
1170562011883	N-terminal domain interface [polypeptide binding]; other site
1170562011884	dimer interface [polypeptide binding]; other site
1170562011885	substrate binding pocket (H-site) [chemical binding]; other site
1170562011886	Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594
1170562011887	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1170562011888	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
1170562011889	Probable transposase; Region: OrfB_IS605; pfam01385
1170562011890	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
1170562011891	Leucine rich repeat variant; Region: LRV; pfam01816
1170562011892	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3864
1170562011893	Putative metallopeptidase domain; Region: DUF2201_N; pfam13203
1170562011894	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
1170562011895	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1170562011896	MoxR-like ATPases [General function prediction only]; Region: COG0714
1170562011897	Walker A motif; other site
1170562011898	ATP binding site [chemical binding]; other site
1170562011899	Walker B motif; other site
1170562011900	arginine finger; other site
1170562011901	Ycf46; Provisional; Region: ycf46; CHL00195
1170562011902	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1170562011903	Walker A motif; other site
1170562011904	ATP binding site [chemical binding]; other site
1170562011905	Walker B motif; other site
1170562011906	arginine finger; other site
1170562011907	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
1170562011908	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1170562011909	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1170562011910	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
1170562011911	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1170562011912	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1170562011913	PemK-like protein; Region: PemK; pfam02452
1170562011914	5'-methylthioadenosine phosphorylase; Provisional; Region: PRK07432
1170562011915	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
1170562011916	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
1170562011917	active site
1170562011918	Zn binding site [ion binding]; other site
1170562011919	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1170562011920	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1170562011921	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
1170562011922	Walker A/P-loop; other site
1170562011923	ATP binding site [chemical binding]; other site
1170562011924	Q-loop/lid; other site
1170562011925	ABC transporter signature motif; other site
1170562011926	Walker B; other site
1170562011927	D-loop; other site
1170562011928	H-loop/switch region; other site
1170562011929	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
1170562011930	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
1170562011931	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
1170562011932	G-X-X-G motif; other site
1170562011933	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
1170562011934	RxxxH motif; other site
1170562011935	putative inner membrane protein translocase component YidC; Provisional; Region: PRK02654
1170562011936	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
1170562011937	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
1170562011938	Bacterial PH domain; Region: DUF304; pfam03703
1170562011939	ribonuclease P; Reviewed; Region: rnpA; PRK03031
1170562011940	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
1170562011941	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
1170562011942	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1170562011943	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1170562011944	active site
1170562011945	dimer interface [polypeptide binding]; other site
1170562011946	motif 1; other site
1170562011947	motif 2; other site
1170562011948	motif 3; other site
1170562011949	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
1170562011950	anticodon binding site; other site
1170562011951	Protein of unknown function (DUF2605); Region: DUF2605; pfam10792
1170562011952	Protein of unknown function (DUF2973); Region: DUF2973; pfam11189
1170562011953	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
1170562011954	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
1170562011955	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1170562011956	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
1170562011957	putative ADP-binding pocket [chemical binding]; other site
1170562011958	Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731
1170562011959	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1170562011960	GAF domain; Region: GAF; pfam01590
1170562011961	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562011962	dimer interface [polypeptide binding]; other site
1170562011963	phosphorylation site [posttranslational modification]
1170562011964	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562011965	ATP binding site [chemical binding]; other site
1170562011966	Mg2+ binding site [ion binding]; other site
1170562011967	G-X-G motif; other site
1170562011968	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1170562011969	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1170562011970	dimer interface [polypeptide binding]; other site
1170562011971	conserved gate region; other site
1170562011972	putative PBP binding loops; other site
1170562011973	ABC-ATPase subunit interface; other site
1170562011974	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
1170562011975	dinuclear metal binding motif [ion binding]; other site
1170562011976	acyl-ACP reductase; Provisional; Region: PRK14982
1170562011977	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
1170562011978	NAD(P) binding pocket [chemical binding]; other site
1170562011979	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
1170562011980	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
1170562011981	short chain dehydrogenase; Provisional; Region: PRK07454
1170562011982	classical (c) SDRs; Region: SDR_c; cd05233
1170562011983	NAD(P) binding site [chemical binding]; other site
1170562011984	active site
1170562011985	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
1170562011986	active site
1170562011987	Ferredoxin [Energy production and conversion]; Region: COG1146
1170562011988	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292
1170562011989	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1170562011990	dimer interface [polypeptide binding]; other site
1170562011991	motif 1; other site
1170562011992	active site
1170562011993	motif 2; other site
1170562011994	motif 3; other site
1170562011995	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1170562011996	HSP70 interaction site [polypeptide binding]; other site
1170562011997	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562011998	TPR repeat; Region: TPR_11; pfam13414
1170562011999	binding surface
1170562012000	TPR motif; other site
1170562012001	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1170562012002	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
1170562012003	active site
1170562012004	dimerization interface [polypeptide binding]; other site
1170562012005	Protein of unknown function (DUF3370); Region: DUF3370; pfam11850
1170562012006	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237
1170562012007	putative substrate binding pocket [chemical binding]; other site
1170562012008	catalytic triad [active]
1170562012009	AB domain interface; other site
1170562012010	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
1170562012011	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
1170562012012	putative active site [active]
1170562012013	oxyanion strand; other site
1170562012014	catalytic triad [active]
1170562012015	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
1170562012016	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1170562012017	S-adenosylmethionine binding site [chemical binding]; other site
1170562012018	Cytochrome B6-F complex subunit 5; Region: PetG; pfam02529
1170562012019	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1170562012020	Cytochrome c; Region: Cytochrom_C; pfam00034
1170562012021	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747
1170562012022	hypothetical protein; Validated; Region: PRK00029
1170562012023	Uncharacterized conserved protein [Function unknown]; Region: COG0397
1170562012024	Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150
1170562012025	Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136
1170562012026	spermidine synthase; Provisional; Region: PRK00811
1170562012027	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1170562012028	S-adenosylmethionine binding site [chemical binding]; other site
1170562012029	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
1170562012030	FO synthase subunit 2; Reviewed; Region: PRK07360
1170562012031	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1170562012032	FeS/SAM binding site; other site
1170562012033	photosystem II protein Psb27; Region: PS_II_psb27; TIGR03044
1170562012034	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
1170562012035	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1170562012036	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1170562012037	S-adenosylmethionine binding site [chemical binding]; other site
1170562012038	tocopherol O-methyltransferase; Region: PLN02244
1170562012039	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1170562012040	S-adenosylmethionine binding site [chemical binding]; other site
1170562012041	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
1170562012042	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
1170562012043	iron-sulfur cluster [ion binding]; other site
1170562012044	[2Fe-2S] cluster binding site [ion binding]; other site
1170562012045	Predicted metal-binding protein [Function unknown]; Region: COG5469
1170562012046	CHAT domain; Region: CHAT; cl17868
1170562012047	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562012048	binding surface
1170562012049	TPR motif; other site
1170562012050	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562012051	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562012052	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562012053	binding surface
1170562012054	TPR motif; other site
1170562012055	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562012056	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562012057	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562012058	binding surface
1170562012059	TPR motif; other site
1170562012060	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562012061	Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550
1170562012062	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
1170562012063	active site
1170562012064	interdomain interaction site; other site
1170562012065	putative metal-binding site [ion binding]; other site
1170562012066	nucleotide binding site [chemical binding]; other site
1170562012067	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1170562012068	domain I; other site
1170562012069	DNA binding groove [nucleotide binding]
1170562012070	phosphate binding site [ion binding]; other site
1170562012071	domain II; other site
1170562012072	domain III; other site
1170562012073	nucleotide binding site [chemical binding]; other site
1170562012074	catalytic site [active]
1170562012075	domain IV; other site
1170562012076	Protein kinase domain; Region: Pkinase; pfam00069
1170562012077	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1170562012078	active site
1170562012079	ATP binding site [chemical binding]; other site
1170562012080	substrate binding site [chemical binding]; other site
1170562012081	activation loop (A-loop); other site
1170562012082	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1170562012083	AAA ATPase domain; Region: AAA_16; pfam13191
1170562012084	Predicted ATPase [General function prediction only]; Region: COG3899
1170562012085	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562012086	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1170562012087	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1170562012088	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1170562012089	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562012090	ATP binding site [chemical binding]; other site
1170562012091	Mg2+ binding site [ion binding]; other site
1170562012092	G-X-G motif; other site
1170562012093	Protein of unknown function (DUF1092); Region: DUF1092; pfam06485
1170562012094	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
1170562012095	active site pocket [active]
1170562012096	putative dimer interface [polypeptide binding]; other site
1170562012097	putative cataytic base [active]
1170562012098	Predicted membrane protein (DUF2232); Region: DUF2232; cl01728
1170562012099	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1170562012100	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1170562012101	ligand binding site [chemical binding]; other site
1170562012102	flexible hinge region; other site
1170562012103	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1170562012104	putative switch regulator; other site
1170562012105	non-specific DNA interactions [nucleotide binding]; other site
1170562012106	DNA binding site [nucleotide binding]
1170562012107	sequence specific DNA binding site [nucleotide binding]; other site
1170562012108	putative cAMP binding site [chemical binding]; other site
1170562012109	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1170562012110	NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein; Region: NHLM_micro_ABC1; TIGR03796
1170562012111	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
1170562012112	putative active site [active]
1170562012113	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1170562012114	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1170562012115	Walker A/P-loop; other site
1170562012116	ATP binding site [chemical binding]; other site
1170562012117	Q-loop/lid; other site
1170562012118	ABC transporter signature motif; other site
1170562012119	Walker B; other site
1170562012120	D-loop; other site
1170562012121	H-loop/switch region; other site
1170562012122	NHLM bacteriocin system secretion protein; Region: NHLM_micro_HlyD; TIGR03794
1170562012123	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1170562012124	HlyD family secretion protein; Region: HlyD_3; pfam13437
1170562012125	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1170562012126	bacteriocin-type transport-associated protein; Region: cyc_nuc_ocin; TIGR03896
1170562012127	ligand binding site [chemical binding]; other site
1170562012128	flexible hinge region; other site
1170562012129	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1170562012130	ligand binding site [chemical binding]; other site
1170562012131	flexible hinge region; other site
1170562012132	RNA polymerase sigma factor; Validated; Region: PRK05949
1170562012133	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1170562012134	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1170562012135	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1170562012136	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1170562012137	DNA binding residues [nucleotide binding]
1170562012138	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
1170562012139	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
1170562012140	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562012141	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562012142	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1170562012143	metal binding site 2 [ion binding]; metal-binding site
1170562012144	putative DNA binding helix; other site
1170562012145	metal binding site 1 [ion binding]; metal-binding site
1170562012146	dimer interface [polypeptide binding]; other site
1170562012147	structural Zn2+ binding site [ion binding]; other site
1170562012148	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1170562012149	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562012150	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1170562012151	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562012152	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562012153	DDE superfamily endonuclease; Region: DDE_5; cl17874
1170562012154	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1170562012155	NACHT domain; Region: NACHT; pfam05729
1170562012156	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
1170562012157	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
1170562012158	Cl- selectivity filter; other site
1170562012159	Cl- binding residues [ion binding]; other site
1170562012160	pore gating glutamate residue; other site
1170562012161	dimer interface [polypeptide binding]; other site
1170562012162	H+/Cl- coupling transport residue; other site
1170562012163	FOG: CBS domain [General function prediction only]; Region: COG0517
1170562012164	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612
1170562012165	The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988
1170562012166	Ligand Binding Site [chemical binding]; other site
1170562012167	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
1170562012168	Ligand Binding Site [chemical binding]; other site
1170562012169	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
1170562012170	dimer interface [polypeptide binding]; other site
1170562012171	FMN binding site [chemical binding]; other site
1170562012172	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1170562012173	putative active site [active]
1170562012174	heme pocket [chemical binding]; other site
1170562012175	Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449
1170562012176	N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797
1170562012177	active site
1170562012178	catalytic site [active]
1170562012179	Domain of unknown function (DUF3536); Region: DUF3536; pfam12055
1170562012180	calcium/proton exchanger (cax); Region: cax; TIGR00378
1170562012181	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
1170562012182	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
1170562012183	spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869
1170562012184	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1170562012185	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1170562012186	Membrane protein of unknown function; Region: DUF360; pfam04020
1170562012187	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
1170562012188	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1170562012189	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1170562012190	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
1170562012191	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1170562012192	FMN binding site [chemical binding]; other site
1170562012193	active site
1170562012194	catalytic residues [active]
1170562012195	substrate binding site [chemical binding]; other site
1170562012196	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
1170562012197	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
1170562012198	Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170
1170562012199	Haemolytic domain; Region: Haemolytic; pfam01809
1170562012200	tellurium resistance terB-like protein; Region: terB_like; cd07177
1170562012201	metal binding site [ion binding]; metal-binding site
1170562012202	Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967
1170562012203	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1170562012204	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1170562012205	phosphopeptide binding site; other site
1170562012206	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1170562012207	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1170562012208	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1170562012209	cyclase homology domain; Region: CHD; cd07302
1170562012210	nucleotidyl binding site; other site
1170562012211	metal binding site [ion binding]; metal-binding site
1170562012212	dimer interface [polypeptide binding]; other site
1170562012213	VanZ like family; Region: VanZ; pfam04892
1170562012214	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
1170562012215	calcium/proton exchanger (cax); Region: cax; TIGR00378
1170562012216	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
1170562012217	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
1170562012218	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
1170562012219	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1170562012220	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
1170562012221	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562012222	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562012223	active site
1170562012224	phosphorylation site [posttranslational modification]
1170562012225	intermolecular recognition site; other site
1170562012226	dimerization interface [polypeptide binding]; other site
1170562012227	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
1170562012228	HlyD family secretion protein; Region: HlyD_3; pfam13437
1170562012229	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1170562012230	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1170562012231	Spherulation-specific family 4; Region: Spherulin4; pfam12138
1170562012232	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
1170562012233	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
1170562012234	NAD binding site [chemical binding]; other site
1170562012235	homodimer interface [polypeptide binding]; other site
1170562012236	active site
1170562012237	substrate binding site [chemical binding]; other site
1170562012238	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
1170562012239	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
1170562012240	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
1170562012241	phosphate binding site [ion binding]; other site
1170562012242	putative substrate binding pocket [chemical binding]; other site
1170562012243	dimer interface [polypeptide binding]; other site
1170562012244	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1170562012245	EamA-like transporter family; Region: EamA; pfam00892
1170562012246	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
1170562012247	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1170562012248	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1170562012249	shikimate binding site; other site
1170562012250	NAD(P) binding site [chemical binding]; other site
1170562012251	hydrolase, alpha/beta fold family protein; Region: PLN02824
1170562012252	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
1170562012253	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
1170562012254	homodimer interface [polypeptide binding]; other site
1170562012255	metal binding site [ion binding]; metal-binding site
1170562012256	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
1170562012257	homodimer interface [polypeptide binding]; other site
1170562012258	active site
1170562012259	putative chemical substrate binding site [chemical binding]; other site
1170562012260	metal binding site [ion binding]; metal-binding site
1170562012261	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
1170562012262	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1170562012263	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1170562012264	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
1170562012265	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1170562012266	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1170562012267	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
1170562012268	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1170562012269	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1170562012270	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
1170562012271	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
1170562012272	putative catalytic cysteine [active]
1170562012273	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
1170562012274	Putative addiction module component; Region: Unstab_antitox; pfam09720
1170562012275	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
1170562012276	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1170562012277	Walker A motif; other site
1170562012278	ATP binding site [chemical binding]; other site
1170562012279	Walker B motif; other site
1170562012280	arginine finger; other site
1170562012281	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1170562012282	Phosphotransferase enzyme family; Region: APH; pfam01636
1170562012283	active site
1170562012284	substrate binding site [chemical binding]; other site
1170562012285	ATP binding site [chemical binding]; other site
1170562012286	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1170562012287	active site
1170562012288	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
1170562012289	O-succinylbenzoic acid--CoA ligase; Reviewed; Region: PRK07445
1170562012290	acyl-activating enzyme (AAE) consensus motif; other site
1170562012291	putative AMP binding site [chemical binding]; other site
1170562012292	putative active site [active]
1170562012293	putative CoA binding site [chemical binding]; other site
1170562012294	O-succinylbenzoate synthase; Provisional; Region: PRK02714
1170562012295	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
1170562012296	active site
1170562012297	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK07419
1170562012298	UbiA prenyltransferase family; Region: UbiA; pfam01040
1170562012299	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
1170562012300	chorismate binding enzyme; Region: Chorismate_bind; cl10555
1170562012301	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
1170562012302	P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923
1170562012303	AAA ATPase domain; Region: AAA_16; pfam13191
1170562012304	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
1170562012305	ABC1 family; Region: ABC1; pfam03109
1170562012306	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1170562012307	active site
1170562012308	ATP binding site [chemical binding]; other site
1170562012309	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562012310	active site
1170562012311	phosphorylation site [posttranslational modification]
1170562012312	intermolecular recognition site; other site
1170562012313	dimerization interface [polypeptide binding]; other site
1170562012314	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
1170562012315	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562012316	putative active site [active]
1170562012317	heme pocket [chemical binding]; other site
1170562012318	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562012319	dimer interface [polypeptide binding]; other site
1170562012320	phosphorylation site [posttranslational modification]
1170562012321	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562012322	ATP binding site [chemical binding]; other site
1170562012323	Mg2+ binding site [ion binding]; other site
1170562012324	G-X-G motif; other site
1170562012325	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562012326	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562012327	active site
1170562012328	phosphorylation site [posttranslational modification]
1170562012329	intermolecular recognition site; other site
1170562012330	dimerization interface [polypeptide binding]; other site
1170562012331	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562012332	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562012333	active site
1170562012334	phosphorylation site [posttranslational modification]
1170562012335	intermolecular recognition site; other site
1170562012336	dimerization interface [polypeptide binding]; other site
1170562012337	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05945
1170562012338	L-aspartate oxidase; Provisional; Region: PRK06175
1170562012339	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1170562012340	DDE superfamily endonuclease; Region: DDE_5; cl17874
1170562012341	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1170562012342	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
1170562012343	polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609
1170562012344	Protein of unknown function (DUF2499); Region: DUF2499; pfam10693
1170562012345	Protein of unknown function (DUF3593); Region: DUF3593; pfam12159
1170562012346	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
1170562012347	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1170562012348	catalytic residues [active]
1170562012349	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
1170562012350	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
1170562012351	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1170562012352	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1170562012353	active site
1170562012354	metal binding site [ion binding]; metal-binding site
1170562012355	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
1170562012356	DNA primase; Validated; Region: dnaG; PRK05667
1170562012357	CHC2 zinc finger; Region: zf-CHC2; pfam01807
1170562012358	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
1170562012359	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
1170562012360	active site
1170562012361	metal binding site [ion binding]; metal-binding site
1170562012362	interdomain interaction site; other site
1170562012363	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
1170562012364	Taspase1_like domains; Taspase1 catalyzes the cleavage of the mix lineage leukemia (MLL) nuclear protein and transcription factor TFIIA. Taspase1 is a threonine aspartase, a member of the Ntn hydrolase superfamily and the type 2 asparaginase family. A...; Region: Taspase1_like; cd04514
1170562012365	active site
1170562012366	dimer interface [polypeptide binding]; other site
1170562012367	catalytic nucleophile [active]
1170562012368	Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013
1170562012369	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1170562012370	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1170562012371	hydrolase, alpha/beta fold family protein; Region: PLN02824
1170562012372	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1170562012373	Domain of unknown function DUF39; Region: DUF39; pfam01837
1170562012374	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562012375	TPR motif; other site
1170562012376	binding surface
1170562012377	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562012378	TPR repeat; Region: TPR_11; pfam13414
1170562012379	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562012380	TPR motif; other site
1170562012381	Predicted membrane protein [Function unknown]; Region: COG2119
1170562012382	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
1170562012383	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
1170562012384	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
1170562012385	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
1170562012386	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
1170562012387	Domain of unknown function (DUF4336); Region: DUF4336; pfam14234
1170562012388	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1170562012389	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1170562012390	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1170562012391	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
1170562012392	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
1170562012393	c-type cytochrome biogenensis protein; Validated; Region: ccs1; CHL00177
1170562012394	ResB-like family; Region: ResB; pfam05140
1170562012395	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
1170562012396	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
1170562012397	cofactor binding site; other site
1170562012398	DNA binding site [nucleotide binding]
1170562012399	substrate interaction site [chemical binding]; other site
1170562012400	HindVP restriction endonuclease; Region: RE_HindVP; pfam09519
1170562012401	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
1170562012402	Uncharacterized conserved protein [Function unknown]; Region: COG3937
1170562012403	Uncharacterized conserved protein (DUF2246); Region: DUF2246; pfam10229
1170562012404	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1170562012405	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1170562012406	Walker A/P-loop; other site
1170562012407	ATP binding site [chemical binding]; other site
1170562012408	Q-loop/lid; other site
1170562012409	ABC transporter signature motif; other site
1170562012410	Walker B; other site
1170562012411	D-loop; other site
1170562012412	H-loop/switch region; other site
1170562012413	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
1170562012414	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
1170562012415	Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074
1170562012416	CoA binding domain; Region: CoA_binding; smart00881
1170562012417	CoA-ligase; Region: Ligase_CoA; pfam00549
1170562012418	Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Region: SucC; COG0045
1170562012419	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
1170562012420	CoA-ligase; Region: Ligase_CoA; pfam00549
1170562012421	Predicted permeases [General function prediction only]; Region: COG0795
1170562012422	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
1170562012423	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
1170562012424	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
1170562012425	Walker A/P-loop; other site
1170562012426	ATP binding site [chemical binding]; other site
1170562012427	Q-loop/lid; other site
1170562012428	ABC transporter signature motif; other site
1170562012429	Walker B; other site
1170562012430	D-loop; other site
1170562012431	H-loop/switch region; other site
1170562012432	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
1170562012433	OstA-like protein; Region: OstA; pfam03968
1170562012434	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
1170562012435	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
1170562012436	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1170562012437	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087
1170562012438	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
1170562012439	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1170562012440	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1170562012441	active site
1170562012442	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1170562012443	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
1170562012444	O-Antigen ligase; Region: Wzy_C; pfam04932
1170562012445	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
1170562012446	Chain length determinant protein; Region: Wzz; pfam02706
1170562012447	AAA domain; Region: AAA_31; pfam13614
1170562012448	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
1170562012449	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
1170562012450	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1170562012451	NlpC/P60 family; Region: NLPC_P60; pfam00877
1170562012452	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
1170562012453	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
1170562012454	Ligand binding site; other site
1170562012455	Putative Catalytic site; other site
1170562012456	DXD motif; other site
1170562012457	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1170562012458	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1170562012459	putative substrate translocation pore; other site
1170562012460	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
1170562012461	trimer interface [polypeptide binding]; other site
1170562012462	dimer interface [polypeptide binding]; other site
1170562012463	putative active site [active]
1170562012464	2TM domain; Region: 2TM; pfam13239
1170562012465	Protein of unknown function (DUF3181); Region: DUF3181; pfam11378
1170562012466	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
1170562012467	heme binding pocket [chemical binding]; other site
1170562012468	heme ligand [chemical binding]; other site
1170562012469	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14317
1170562012470	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
1170562012471	active site
1170562012472	substrate binding site [chemical binding]; other site
1170562012473	metal binding site [ion binding]; metal-binding site
1170562012474	Protein of unknown function (DUF760); Region: DUF760; pfam05542
1170562012475	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
1170562012476	active site
1170562012477	8-oxo-dGMP binding site [chemical binding]; other site
1170562012478	nudix motif; other site
1170562012479	metal binding site [ion binding]; metal-binding site
1170562012480	Predicted membrane protein [Function unknown]; Region: COG2119
1170562012481	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
1170562012482	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
1170562012483	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
1170562012484	dimerization interface [polypeptide binding]; other site
1170562012485	DPS ferroxidase diiron center [ion binding]; other site
1170562012486	ion pore; other site
1170562012487	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
1170562012488	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
1170562012489	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1170562012490	FMN binding site [chemical binding]; other site
1170562012491	active site
1170562012492	catalytic residues [active]
1170562012493	substrate binding site [chemical binding]; other site
1170562012494	Phosphoketolase [Carbohydrate transport and metabolism]; Region: COG3957
1170562012495	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
1170562012496	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
1170562012497	TPP-binding site [chemical binding]; other site
1170562012498	Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861
1170562012499	Lecithin retinol acyltransferase; Region: LRAT; pfam04970
1170562012500	TPR repeat; Region: TPR_11; pfam13414
1170562012501	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562012502	binding surface
1170562012503	TPR motif; other site
1170562012504	TPR repeat; Region: TPR_11; pfam13414
1170562012505	TPR repeat; Region: TPR_11; pfam13414
1170562012506	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562012507	binding surface
1170562012508	TPR motif; other site
1170562012509	TPR repeat; Region: TPR_11; pfam13414
1170562012510	D1 subunit  of photosystem II (PS II); Region: Photosystem-II_D1; cd09289
1170562012511	protein I interface; other site
1170562012512	D2 interface; other site
1170562012513	protein T interface; other site
1170562012514	chlorophyll binding site; other site
1170562012515	beta carotene binding site; other site
1170562012516	pheophytin binding site; other site
1170562012517	manganese-stabilizing polypeptide interface; other site
1170562012518	CP43 interface; other site
1170562012519	protein L interface; other site
1170562012520	oxygen evolving complex binding site; other site
1170562012521	bromide binding site; other site
1170562012522	quinone binding site; other site
1170562012523	Fe binding site [ion binding]; other site
1170562012524	core light harvesting interface; other site
1170562012525	cytochrome b559 alpha subunit interface; other site
1170562012526	cytochrome c-550 interface; other site
1170562012527	protein J interface; other site
1170562012528	D1 subunit  of photosystem II (PS II); Region: Photosystem-II_D1; cd09289
1170562012529	protein I interface; other site
1170562012530	D2 interface; other site
1170562012531	protein T interface; other site
1170562012532	chlorophyll binding site; other site
1170562012533	beta carotene binding site; other site
1170562012534	pheophytin binding site; other site
1170562012535	manganese-stabilizing polypeptide interface; other site
1170562012536	CP43 interface; other site
1170562012537	protein L interface; other site
1170562012538	oxygen evolving complex binding site; other site
1170562012539	bromide binding site; other site
1170562012540	quinone binding site; other site
1170562012541	Fe binding site [ion binding]; other site
1170562012542	core light harvesting interface; other site
1170562012543	cytochrome b559 alpha subunit interface; other site
1170562012544	cytochrome c-550 interface; other site
1170562012545	protein J interface; other site
1170562012546	GTP-binding protein LepA; Provisional; Region: PRK05433
1170562012547	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
1170562012548	G1 box; other site
1170562012549	putative GEF interaction site [polypeptide binding]; other site
1170562012550	GTP/Mg2+ binding site [chemical binding]; other site
1170562012551	Switch I region; other site
1170562012552	G2 box; other site
1170562012553	G3 box; other site
1170562012554	Switch II region; other site
1170562012555	G4 box; other site
1170562012556	G5 box; other site
1170562012557	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
1170562012558	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
1170562012559	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
1170562012560	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1170562012561	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1170562012562	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562012563	dimer interface [polypeptide binding]; other site
1170562012564	phosphorylation site [posttranslational modification]
1170562012565	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562012566	ATP binding site [chemical binding]; other site
1170562012567	Mg2+ binding site [ion binding]; other site
1170562012568	G-X-G motif; other site
1170562012569	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
1170562012570	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1170562012571	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1170562012572	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
1170562012573	P-loop, Walker A motif; other site
1170562012574	Base recognition motif; other site
1170562012575	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
1170562012576	FOG: WD40 repeat [General function prediction only]; Region: COG2319
1170562012577	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
1170562012578	structural tetrad; other site
1170562012579	Protein kinase domain; Region: Pkinase; pfam00069
1170562012580	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1170562012581	active site
1170562012582	ATP binding site [chemical binding]; other site
1170562012583	substrate binding site [chemical binding]; other site
1170562012584	activation loop (A-loop); other site
1170562012585	AAA ATPase domain; Region: AAA_16; pfam13191
1170562012586	Predicted ATPase [General function prediction only]; Region: COG3899
1170562012587	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1170562012588	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1170562012589	PAS domain S-box; Region: sensory_box; TIGR00229
1170562012590	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1170562012591	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562012592	ATP binding site [chemical binding]; other site
1170562012593	Mg2+ binding site [ion binding]; other site
1170562012594	G-X-G motif; other site
1170562012595	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1170562012596	putative phosphate acyltransferase; Provisional; Region: PRK05331
1170562012597	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
1170562012598	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1170562012599	dimer interface [polypeptide binding]; other site
1170562012600	active site
1170562012601	CoA binding pocket [chemical binding]; other site
1170562012602	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1170562012603	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1170562012604	Protein of unknown function (DUF1092); Region: DUF1092; pfam06485
1170562012605	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
1170562012606	Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977
1170562012607	ArsC family; Region: ArsC; pfam03960
1170562012608	catalytic residue [active]
1170562012609	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
1170562012610	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
1170562012611	metal binding site [ion binding]; metal-binding site
1170562012612	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1170562012613	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1170562012614	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1170562012615	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1170562012616	ABC-ATPase subunit  interface; other site
1170562012617	dimer interface [polypeptide binding]; other site
1170562012618	putative PBP binding regions; other site
1170562012619	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1170562012620	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1170562012621	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1170562012622	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1170562012623	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
1170562012624	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
1170562012625	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1170562012626	active site
1170562012627	HIGH motif; other site
1170562012628	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1170562012629	KMSKS motif; other site
1170562012630	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
1170562012631	tRNA binding surface [nucleotide binding]; other site
1170562012632	anticodon binding site; other site
1170562012633	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
1170562012634	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
1170562012635	Protein kinase domain; Region: Pkinase; pfam00069
1170562012636	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1170562012637	active site
1170562012638	ATP binding site [chemical binding]; other site
1170562012639	substrate binding site [chemical binding]; other site
1170562012640	substrate binding site [chemical binding]; other site
1170562012641	activation loop (A-loop); other site
1170562012642	activation loop (A-loop); other site
1170562012643	AAA ATPase domain; Region: AAA_16; pfam13191
1170562012644	Predicted ATPase [General function prediction only]; Region: COG3899
1170562012645	Walker A motif; other site
1170562012646	ATP binding site [chemical binding]; other site
1170562012647	Walker B motif; other site
1170562012648	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1170562012649	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1170562012650	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562012651	ATP binding site [chemical binding]; other site
1170562012652	Mg2+ binding site [ion binding]; other site
1170562012653	G-X-G motif; other site
1170562012654	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
1170562012655	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1170562012656	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1170562012657	catalytic residue [active]
1170562012658	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
1170562012659	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
1170562012660	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
1170562012661	active site
1170562012662	(T/H)XGH motif; other site
1170562012663	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033
1170562012664	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05952
1170562012665	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1170562012666	dimer interface [polypeptide binding]; other site
1170562012667	active site
1170562012668	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
1170562012669	active site
1170562012670	PRC-barrel domain; Region: PRC; pfam05239
1170562012671	PRC-barrel domain; Region: PRC; pfam05239
1170562012672	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
1170562012673	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1170562012674	Walker A/P-loop; other site
1170562012675	ATP binding site [chemical binding]; other site
1170562012676	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
1170562012677	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1170562012678	ABC transporter signature motif; other site
1170562012679	Walker B; other site
1170562012680	D-loop; other site
1170562012681	H-loop/switch region; other site
1170562012682	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1170562012683	putative active site [active]
1170562012684	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562012685	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
1170562012686	Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503
1170562012687	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
1170562012688	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862
1170562012689	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
1170562012690	ligand binding site; other site
1170562012691	oligomer interface; other site
1170562012692	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
1170562012693	dimer interface [polypeptide binding]; other site
1170562012694	N-terminal domain interface [polypeptide binding]; other site
1170562012695	sulfate 1 binding site; other site
1170562012696	chaperone protein DnaJ; Provisional; Region: PRK14299
1170562012697	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1170562012698	HSP70 interaction site [polypeptide binding]; other site
1170562012699	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1170562012700	substrate binding site [polypeptide binding]; other site
1170562012701	dimer interface [polypeptide binding]; other site
1170562012702	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1170562012703	putative active site [active]
1170562012704	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
1170562012705	putative catalytic residues [active]
1170562012706	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1170562012707	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
1170562012708	dimer interface [polypeptide binding]; other site
1170562012709	decamer (pentamer of dimers) interface [polypeptide binding]; other site
1170562012710	catalytic triad [active]
1170562012711	peroxidatic and resolving cysteines [active]
1170562012712	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
1170562012713	Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439
1170562012714	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
1170562012715	sensory histidine kinase CreC; Provisional; Region: PRK11100
1170562012716	Protein of unknown function (DUF1257); Region: DUF1257; pfam06868
1170562012717	Ycf46; Provisional; Region: ycf46; CHL00195
1170562012718	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1170562012719	Walker A motif; other site
1170562012720	ATP binding site [chemical binding]; other site
1170562012721	Walker B motif; other site
1170562012722	arginine finger; other site
1170562012723	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
1170562012724	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1170562012725	E3 interaction surface; other site
1170562012726	lipoyl attachment site [posttranslational modification]; other site
1170562012727	e3 binding domain; Region: E3_binding; pfam02817
1170562012728	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1170562012729	Protein of unknown function (DUF2869); Region: DUF2869; pfam11068
1170562012730	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
1170562012731	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
1170562012732	acyl-activating enzyme (AAE) consensus motif; other site
1170562012733	putative AMP binding site [chemical binding]; other site
1170562012734	putative active site [active]
1170562012735	putative CoA binding site [chemical binding]; other site
1170562012736	Electron transfer DM13; Region: DM13; pfam10517
1170562012737	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02645
1170562012738	ATP-NAD kinase; Region: NAD_kinase; pfam01513
1170562012739	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
1170562012740	NADH dehydrogenase subunit 6; Region: ndhG; CHL00016
1170562012741	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
1170562012742	NADH dehydrogenase subunit J; Provisional; Region: PRK06439
1170562012743	NADH-plastoquinone oxidoreductase subunit I protein; Region: ndhI; TIGR00403
1170562012744	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1170562012745	NADH dehydrogenase; Region: NADHdh; cl00469
1170562012746	citrate synthase; Provisional; Region: PRK14036
1170562012747	Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_1; cd06112
1170562012748	dimer interface [polypeptide binding]; other site
1170562012749	active site
1170562012750	citrylCoA binding site [chemical binding]; other site
1170562012751	oxalacetate/citrate binding site [chemical binding]; other site
1170562012752	coenzyme A binding site [chemical binding]; other site
1170562012753	catalytic triad [active]
1170562012754	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1170562012755	catalytic core [active]
1170562012756	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
1170562012757	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1170562012758	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
1170562012759	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
1170562012760	Walker A/P-loop; other site
1170562012761	ATP binding site [chemical binding]; other site
1170562012762	Q-loop/lid; other site
1170562012763	ABC transporter signature motif; other site
1170562012764	Walker B; other site
1170562012765	D-loop; other site
1170562012766	H-loop/switch region; other site
1170562012767	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
1170562012768	putative carbohydrate binding site [chemical binding]; other site
1170562012769	Methyltransferase domain; Region: Methyltransf_24; pfam13578
1170562012770	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1170562012771	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1170562012772	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1170562012773	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1170562012774	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1170562012775	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1170562012776	S-adenosylmethionine binding site [chemical binding]; other site
1170562012777	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1170562012778	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1170562012779	active site
1170562012780	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1170562012781	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1170562012782	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1170562012783	active site
1170562012784	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
1170562012785	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
1170562012786	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1170562012787	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1170562012788	active site
1170562012789	catalytic tetrad [active]
1170562012790	helicase 45; Provisional; Region: PTZ00424
1170562012791	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1170562012792	ATP binding site [chemical binding]; other site
1170562012793	Mg++ binding site [ion binding]; other site
1170562012794	motif III; other site
1170562012795	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1170562012796	nucleotide binding region [chemical binding]; other site
1170562012797	ATP-binding site [chemical binding]; other site
1170562012798	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
1170562012799	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1170562012800	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1170562012801	FeS/SAM binding site; other site
1170562012802	Predicted TIM-barrel enzyme [General function prediction only]; Region: SgcQ; COG0434
1170562012803	Vitamin K epoxide reductase family in bacteria and plants; Region: VKOR_1; cd12916
1170562012804	putative active site [active]
1170562012805	substrate binding site [chemical binding]; other site
1170562012806	redox center [active]
1170562012807	Protein Disulfide Isomerase (PDIa) family, redox active TRX domains; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family include PDI...; Region: PDI_a_family; cd02961
1170562012808	catalytic residues [active]
1170562012809	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
1170562012810	CHASE2 domain; Region: CHASE2; pfam05226
1170562012811	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562012812	PAS fold; Region: PAS_4; pfam08448
1170562012813	putative active site [active]
1170562012814	heme pocket [chemical binding]; other site
1170562012815	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1170562012816	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1170562012817	metal binding site [ion binding]; metal-binding site
1170562012818	active site
1170562012819	I-site; other site
1170562012820	L-aspartate oxidase; Provisional; Region: PRK07395
1170562012821	L-aspartate oxidase; Provisional; Region: PRK06175
1170562012822	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1170562012823	photosystem II complex extrinsic protein precursor U; Provisional; Region: psbU; PRK02515
1170562012824	Protein of unknown function (DUF3120); Region: DUF3120; pfam11318
1170562012825	Bacitracin resistance protein BacA; Region: BacA; pfam02673
1170562012826	Protein of unknown function (DUF2930); Region: DUF2930; pfam11152
1170562012827	Ycf27; Reviewed; Region: orf27; CHL00148
1170562012828	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562012829	active site
1170562012830	phosphorylation site [posttranslational modification]
1170562012831	intermolecular recognition site; other site
1170562012832	dimerization interface [polypeptide binding]; other site
1170562012833	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1170562012834	DNA binding site [nucleotide binding]
1170562012835	DNA repair protein RadA; Provisional; Region: PRK11823
1170562012836	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
1170562012837	Walker A motif/ATP binding site; other site
1170562012838	ATP binding site [chemical binding]; other site
1170562012839	Walker B motif; other site
1170562012840	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1170562012841	RNA polymerase sigma factor SigD; Validated; Region: PRK07405
1170562012842	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1170562012843	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1170562012844	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1170562012845	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1170562012846	DNA binding residues [nucleotide binding]
1170562012847	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
1170562012848	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1170562012849	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1170562012850	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
1170562012851	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1170562012852	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1170562012853	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
1170562012854	IMP binding site; other site
1170562012855	dimer interface [polypeptide binding]; other site
1170562012856	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
1170562012857	dimer interface [polypeptide binding]; other site
1170562012858	[2Fe-2S] cluster binding site [ion binding]; other site
1170562012859	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1170562012860	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
1170562012861	putative dimer interface [polypeptide binding]; other site
1170562012862	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
1170562012863	RNA/DNA hybrid binding site [nucleotide binding]; other site
1170562012864	active site
1170562012865	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
1170562012866	active site
1170562012867	Predicted membrane protein [Function unknown]; Region: COG2324
1170562012868	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1170562012869	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1170562012870	active site
1170562012871	metal binding site [ion binding]; metal-binding site
1170562012872	Protein of unknown function (DUF4090); Region: DUF4090; pfam13319
1170562012873	Maf-like protein; Region: Maf; pfam02545
1170562012874	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
1170562012875	active site
1170562012876	dimer interface [polypeptide binding]; other site
1170562012877	PsbP; Region: PsbP; pfam01789
1170562012878	Uncharacterized conserved protein [Function unknown]; Region: COG5634
1170562012879	Lamin Tail Domain; Region: LTD; pfam00932
1170562012880	GAF domain; Region: GAF_3; pfam13492
1170562012881	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
1170562012882	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
1170562012883	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
1170562012884	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
1170562012885	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1170562012886	P loop; other site
1170562012887	GTP binding site [chemical binding]; other site
1170562012888	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
1170562012889	putative RNA binding site [nucleotide binding]; other site
1170562012890	Uncharacterized conserved protein [Function unknown]; Region: COG2928
1170562012891	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1170562012892	putative active site [active]
1170562012893	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1170562012894	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
1170562012895	putative metal binding site; other site
1170562012896	Ribosomal protein L9 [Translation, ribosomal structure and biogenesis]; Region: RplI; COG0359
1170562012897	transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282
1170562012898	Protein of unknown function (DUF2488); Region: Ycf54; pfam10674
1170562012899	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
1170562012900	active site
1170562012901	hydrophilic channel; other site
1170562012902	dimerization interface [polypeptide binding]; other site
1170562012903	catalytic residues [active]
1170562012904	active site lid [active]
1170562012905	RNA methyltransferase, RsmE family; Region: TIGR00046
1170562012906	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
1170562012907	Peptidase M50B-like; Region: Peptidase_M50B; pfam13398
1170562012908	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
1170562012909	Clp amino terminal domain; Region: Clp_N; pfam02861
1170562012910	Clp amino terminal domain; Region: Clp_N; pfam02861
1170562012911	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1170562012912	Walker A motif; other site
1170562012913	ATP binding site [chemical binding]; other site
1170562012914	Walker B motif; other site
1170562012915	arginine finger; other site
1170562012916	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1170562012917	Walker A motif; other site
1170562012918	ATP binding site [chemical binding]; other site
1170562012919	Walker B motif; other site
1170562012920	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1170562012921	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1170562012922	S-adenosylmethionine binding site [chemical binding]; other site
1170562012923	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
1170562012924	Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557
1170562012925	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
1170562012926	homodimer interface [polypeptide binding]; other site
1170562012927	Walker A motif; other site
1170562012928	ATP binding site [chemical binding]; other site
1170562012929	hydroxycobalamin binding site [chemical binding]; other site
1170562012930	Walker B motif; other site
1170562012931	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
1170562012932	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
1170562012933	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
1170562012934	NAD binding site [chemical binding]; other site
1170562012935	dimerization interface [polypeptide binding]; other site
1170562012936	product binding site; other site
1170562012937	substrate binding site [chemical binding]; other site
1170562012938	zinc binding site [ion binding]; other site
1170562012939	catalytic residues [active]
1170562012940	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
1170562012941	SnoaL-like domain; Region: SnoaL_3; pfam13474
1170562012942	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
1170562012943	Mg binding site [ion binding]; other site
1170562012944	nucleotide binding site [chemical binding]; other site
1170562012945	putative protofilament interface [polypeptide binding]; other site
1170562012946	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1170562012947	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1170562012948	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1170562012949	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1170562012950	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
1170562012951	Ligand Binding Site [chemical binding]; other site
1170562012952	Transposase domain (DUF772); Region: DUF772; pfam05598
1170562012953	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1170562012954	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1170562012955	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
1170562012956	Domain of unknown function (DUF4212); Region: DUF4212; pfam13937
1170562012957	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
1170562012958	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
1170562012959	Na binding site [ion binding]; other site
1170562012960	cob(I)yrinic acid a,c-diamide adenosyltransferase; Validated; Region: PRK07414
1170562012961	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
1170562012962	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1170562012963	Probable transposase; Region: OrfB_IS605; pfam01385
1170562012964	Uncharacterized conserved protein (DUF2349); Region: DUF2349; pfam09779
1170562012965	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
1170562012966	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1170562012967	trimer interface [polypeptide binding]; other site
1170562012968	active site
1170562012969	hydrolase, alpha/beta fold family protein; Region: PLN02824
1170562012970	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
1170562012971	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1170562012972	putative catalytic residue [active]
1170562012973	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
1170562012974	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1170562012975	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1170562012976	catalytic residue [active]
1170562012977	Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116
1170562012978	PLD-like domain; Region: PLDc_2; pfam13091
1170562012979	putative active site [active]
1170562012980	catalytic site [active]
1170562012981	Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173
1170562012982	PLD-like domain; Region: PLDc_2; pfam13091
1170562012983	putative active site [active]
1170562012984	catalytic site [active]
1170562012985	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562012986	active site
1170562012987	phosphorylation site [posttranslational modification]
1170562012988	intermolecular recognition site; other site
1170562012989	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1170562012990	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562012991	putative active site [active]
1170562012992	heme pocket [chemical binding]; other site
1170562012993	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562012994	dimer interface [polypeptide binding]; other site
1170562012995	phosphorylation site [posttranslational modification]
1170562012996	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562012997	ATP binding site [chemical binding]; other site
1170562012998	Mg2+ binding site [ion binding]; other site
1170562012999	G-X-G motif; other site
1170562013000	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562013001	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562013002	active site
1170562013003	phosphorylation site [posttranslational modification]
1170562013004	intermolecular recognition site; other site
1170562013005	dimerization interface [polypeptide binding]; other site
1170562013006	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562013007	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562013008	active site
1170562013009	phosphorylation site [posttranslational modification]
1170562013010	intermolecular recognition site; other site
1170562013011	dimerization interface [polypeptide binding]; other site
1170562013012	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1170562013013	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1170562013014	putative active site [active]
1170562013015	heme pocket [chemical binding]; other site
1170562013016	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562013017	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1170562013018	putative active site [active]
1170562013019	heme pocket [chemical binding]; other site
1170562013020	PAS domain; Region: PAS; smart00091
1170562013021	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1170562013022	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562013023	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1170562013024	putative active site [active]
1170562013025	heme pocket [chemical binding]; other site
1170562013026	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562013027	putative active site [active]
1170562013028	heme pocket [chemical binding]; other site
1170562013029	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562013030	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1170562013031	putative active site [active]
1170562013032	heme pocket [chemical binding]; other site
1170562013033	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562013034	heme pocket [chemical binding]; other site
1170562013035	putative active site [active]
1170562013036	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562013037	dimer interface [polypeptide binding]; other site
1170562013038	phosphorylation site [posttranslational modification]
1170562013039	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562013040	ATP binding site [chemical binding]; other site
1170562013041	Mg2+ binding site [ion binding]; other site
1170562013042	G-X-G motif; other site
1170562013043	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
1170562013044	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
1170562013045	Uncharacterized conserved protein [Function unknown]; Region: COG1432
1170562013046	LabA_like proteins; Region: LabA; cd10911
1170562013047	putative metal binding site [ion binding]; other site
1170562013048	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
1170562013049	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
1170562013050	active site
1170562013051	HIGH motif; other site
1170562013052	KMSKS motif; other site
1170562013053	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
1170562013054	anticodon binding site; other site
1170562013055	tRNA binding surface [nucleotide binding]; other site
1170562013056	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1170562013057	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1170562013058	putative acyl-acceptor binding pocket; other site
1170562013059	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
1170562013060	Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279
1170562013061	active site
1170562013062	preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870
1170562013063	phosphoglyceromutase; Provisional; Region: PRK05434
1170562013064	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
1170562013065	Uncharacterized small conserved protein [Function unknown]; Region: COG5626
1170562013066	Uncharacterized conserved protein [Function unknown]; Region: COG1434
1170562013067	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1170562013068	putative active site [active]
1170562013069	Tocopherol cyclase; Region: Tocopherol_cycl; pfam14249
1170562013070	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
1170562013071	FOG: WD40 repeat [General function prediction only]; Region: COG2319
1170562013072	structural tetrad; other site
1170562013073	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1170562013074	TPR repeat; Region: TPR_11; pfam13414
1170562013075	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562013076	binding surface
1170562013077	TPR motif; other site
1170562013078	DNA polymerase III subunit alpha; Reviewed; Region: PRK07373
1170562013079	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1170562013080	generic binding surface I; other site
1170562013081	generic binding surface II; other site
1170562013082	adenylosuccinate lyase; Provisional; Region: PRK07380
1170562013083	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
1170562013084	tetramer interface [polypeptide binding]; other site
1170562013085	active site
1170562013086	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
1170562013087	Predicted metal-binding protein [General function prediction only]; Region: COG3019
1170562013088	Heme NO binding associated; Region: HNOBA; pfam07701
1170562013089	Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044
1170562013090	cyclase homology domain; Region: CHD; cd07302
1170562013091	nucleotidyl binding site; other site
1170562013092	metal binding site [ion binding]; metal-binding site
1170562013093	dimer interface [polypeptide binding]; other site
1170562013094	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
1170562013095	oligomeric interface; other site
1170562013096	putative active site [active]
1170562013097	homodimer interface [polypeptide binding]; other site
1170562013098	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
1170562013099	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1170562013100	putative substrate translocation pore; other site
1170562013101	Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236
1170562013102	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1170562013103	active site
1170562013104	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562013105	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562013106	binding surface
1170562013107	TPR motif; other site
1170562013108	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562013109	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562013110	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562013111	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1170562013112	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1170562013113	DNA binding residues [nucleotide binding]
1170562013114	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
1170562013115	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02705
1170562013116	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1170562013117	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1170562013118	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
1170562013119	AAA ATPase domain; Region: AAA_16; pfam13191
1170562013120	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672
1170562013121	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
1170562013122	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1170562013123	active site
1170562013124	AAA ATPase domain; Region: AAA_16; pfam13191
1170562013125	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458
1170562013126	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
1170562013127	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1170562013128	active site
1170562013129	metal binding site [ion binding]; metal-binding site
1170562013130	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
1170562013131	dimer interface [polypeptide binding]; other site
1170562013132	allosteric magnesium binding site [ion binding]; other site
1170562013133	active site
1170562013134	aspartate-rich active site metal binding site; other site
1170562013135	Schiff base residues; other site
1170562013136	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1170562013137	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
1170562013138	C-terminal domain interface [polypeptide binding]; other site
1170562013139	GSH binding site (G-site) [chemical binding]; other site
1170562013140	dimer interface [polypeptide binding]; other site
1170562013141	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
1170562013142	Fasciclin domain; Region: Fasciclin; pfam02469
1170562013143	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
1170562013144	4Fe-4S binding domain; Region: Fer4; pfam00037
1170562013145	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
1170562013146	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
1170562013147	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
1170562013148	hexamer interface [polypeptide binding]; other site
1170562013149	metal binding site [ion binding]; metal-binding site
1170562013150	substrate binding site [chemical binding]; other site
1170562013151	Peptidase S8 family domain, uncharacterized subfamily 2; Region: Peptidases_S8_2; cd07488
1170562013152	putative catalytic residues [active]
1170562013153	putative active site [active]
1170562013154	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1170562013155	dimer interface [polypeptide binding]; other site
1170562013156	ADP-ribose binding site [chemical binding]; other site
1170562013157	active site
1170562013158	nudix motif; other site
1170562013159	metal binding site [ion binding]; metal-binding site
1170562013160	TRX-like protein A (TxlA) family; TxlA was originally isolated from the cyanobacterium Synechococcus. It is found only in oxygenic photosynthetic organisms. TRX is a small enzyme that participate in redox reactions, via the reversible oxidation of an...; Region: TxlA; cd02950
1170562013161	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1170562013162	catalytic residues [active]
1170562013163	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
1170562013164	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1170562013165	Tic22-like family; Region: Tic22; cl04468
1170562013166	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1170562013167	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1170562013168	Coenzyme A binding pocket [chemical binding]; other site
1170562013169	Fragile site-associated protein C-terminus; Region: FSA_C; pfam10479
1170562013170	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1170562013171	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
1170562013172	catalytic site [active]
1170562013173	UGMP family protein; Validated; Region: PRK09604
1170562013174	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
1170562013175	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
1170562013176	Photosystem I reaction centre subunit III; Region: PSI_PsaF; pfam02507
1170562013177	Photosystem I reaction centre subunit IX / PsaJ; Region: PSI_PsaJ; cl03320
1170562013178	Photosystem I reaction centre subunit XI; Region: PsaL; pfam02605
1170562013179	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
1170562013180	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
1170562013181	catalytic site [active]
1170562013182	G-X2-G-X-G-K; other site
1170562013183	hypothetical protein; Provisional; Region: PRK04323
1170562013184	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1170562013185	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1170562013186	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
1170562013187	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1170562013188	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1170562013189	substrate binding pocket [chemical binding]; other site
1170562013190	chain length determination region; other site
1170562013191	substrate-Mg2+ binding site; other site
1170562013192	catalytic residues [active]
1170562013193	aspartate-rich region 1; other site
1170562013194	active site lid residues [active]
1170562013195	aspartate-rich region 2; other site
1170562013196	glutamate racemase; Provisional; Region: PRK00865
1170562013197	AMIN domain; Region: AMIN; pfam11741
1170562013198	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1170562013199	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1170562013200	active site
1170562013201	metal binding site [ion binding]; metal-binding site
1170562013202	AMIN domain; Region: AMIN; pfam11741
1170562013203	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1170562013204	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1170562013205	active site
1170562013206	metal binding site [ion binding]; metal-binding site
1170562013207	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1170562013208	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1170562013209	EVE domain; Region: EVE; pfam01878
1170562013210	Uncharacterized conserved protein [Function unknown]; Region: COG2968
1170562013211	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
1170562013212	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1170562013213	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1170562013214	dimer interface [polypeptide binding]; other site
1170562013215	ssDNA binding site [nucleotide binding]; other site
1170562013216	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1170562013217	rod shape-determining protein MreB; Provisional; Region: PRK13927
1170562013218	MreB and similar proteins; Region: MreB_like; cd10225
1170562013219	nucleotide binding site [chemical binding]; other site
1170562013220	Mg binding site [ion binding]; other site
1170562013221	putative protofilament interaction site [polypeptide binding]; other site
1170562013222	RodZ interaction site [polypeptide binding]; other site
1170562013223	rod shape-determining protein MreC; Provisional; Region: PRK13922
1170562013224	rod shape-determining protein MreC; Region: MreC; pfam04085
1170562013225	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891
1170562013226	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
1170562013227	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
1170562013228	catalytic motif [active]
1170562013229	Zn binding site [ion binding]; other site
1170562013230	RibD C-terminal domain; Region: RibD_C; cl17279
1170562013231	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
1170562013232	Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602
1170562013233	putative active site [active]
1170562013234	catalytic site [active]
1170562013235	putative metal binding site [ion binding]; other site
1170562013236	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
1170562013237	Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602
1170562013238	putative active site [active]
1170562013239	catalytic site [active]
1170562013240	putative metal binding site [ion binding]; other site
1170562013241	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222
1170562013242	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
1170562013243	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
1170562013244	Amidinotransferase; Region: Amidinotransf; cl12043
1170562013245	Uncharacterized conserved protein [Function unknown]; Region: COG1915
1170562013246	Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cd12144
1170562013247	homodimer interface [polypeptide binding]; other site
1170562013248	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
1170562013249	catalytic site [active]
1170562013250	putative active site [active]
1170562013251	putative substrate binding site [chemical binding]; other site
1170562013252	TPR repeat; Region: TPR_11; pfam13414
1170562013253	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562013254	binding surface
1170562013255	TPR motif; other site
1170562013256	TPR repeat; Region: TPR_11; pfam13414
1170562013257	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562013258	binding surface
1170562013259	TPR motif; other site
1170562013260	TPR repeat; Region: TPR_11; pfam13414
1170562013261	Protein kinase domain; Region: Pkinase; pfam00069
1170562013262	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1170562013263	active site
1170562013264	ATP binding site [chemical binding]; other site
1170562013265	substrate binding site [chemical binding]; other site
1170562013266	activation loop (A-loop); other site
1170562013267	AAA ATPase domain; Region: AAA_16; pfam13191
1170562013268	Predicted ATPase [General function prediction only]; Region: COG3899
1170562013269	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1170562013270	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1170562013271	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562013272	putative active site [active]
1170562013273	heme pocket [chemical binding]; other site
1170562013274	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1170562013275	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562013276	ATP binding site [chemical binding]; other site
1170562013277	Mg2+ binding site [ion binding]; other site
1170562013278	G-X-G motif; other site
1170562013279	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1170562013280	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1170562013281	Coenzyme A binding pocket [chemical binding]; other site
1170562013282	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1170562013283	AMIN domain; Region: AMIN; pfam11741
1170562013284	Secretin and TonB N terminus short domain; Region: STN; pfam07660
1170562013285	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
1170562013286	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
1170562013287	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
1170562013288	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
1170562013289	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
1170562013290	Cell division protein FtsA; Region: FtsA; cl17206
1170562013291	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1170562013292	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1170562013293	Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714
1170562013294	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1170562013295	active site
1170562013296	ATP binding site [chemical binding]; other site
1170562013297	substrate binding site [chemical binding]; other site
1170562013298	activation loop (A-loop); other site
1170562013299	Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775
1170562013300	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1170562013301	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
1170562013302	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1170562013303	Surface antigen; Region: Bac_surface_Ag; pfam01103
1170562013304	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370
1170562013305	conserved hypothetical protein; Region: TIGR03492
1170562013306	sialate_O-acetylesterase_like subfamily of the SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: sialate_O-acetylesterase_like2; cd01828
1170562013307	active site
1170562013308	catalytic triad [active]
1170562013309	oxyanion hole [active]
1170562013310	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
1170562013311	DNA methylase; Region: N6_N4_Mtase; pfam01555
1170562013312	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
1170562013313	putative bicarbonate transporter, IctB family; Region: 2A73; TIGR00947
1170562013314	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1170562013315	GAF domain; Region: GAF; pfam01590
1170562013316	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1170562013317	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562013318	dimer interface [polypeptide binding]; other site
1170562013319	phosphorylation site [posttranslational modification]
1170562013320	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
1170562013321	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1170562013322	inhibitor-cofactor binding pocket; inhibition site
1170562013323	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1170562013324	catalytic residue [active]
1170562013325	cyanoexosortase B; Region: cyanoexo_CrtB; TIGR04156
1170562013326	Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721
1170562013327	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
1170562013328	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1170562013329	Walker A/P-loop; other site
1170562013330	ATP binding site [chemical binding]; other site
1170562013331	Q-loop/lid; other site
1170562013332	ABC transporter signature motif; other site
1170562013333	Walker B; other site
1170562013334	D-loop; other site
1170562013335	H-loop/switch region; other site
1170562013336	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1170562013337	dimer interface [polypeptide binding]; other site
1170562013338	ABC-ATPase subunit interface; other site
1170562013339	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
1170562013340	Uncharacterized subfamily of  glycoside hydrolase family 57 (GH57); Region: GH57N_like_1; cd10798
1170562013341	active site
1170562013342	catalytic site [active]
1170562013343	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562013344	putative active site [active]
1170562013345	heme pocket [chemical binding]; other site
1170562013346	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562013347	ATP binding site [chemical binding]; other site
1170562013348	G-X-G motif; other site
1170562013349	Protein of unknown function (DUF751); Region: DUF751; pfam05421
1170562013350	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
1170562013351	Domain of unknown function (DUF4327); Region: DUF4327; pfam14217
1170562013352	adenylate kinase; Reviewed; Region: adk; PRK00279
1170562013353	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
1170562013354	AMP-binding site [chemical binding]; other site
1170562013355	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
1170562013356	ribonuclease PH; Reviewed; Region: rph; PRK00173
1170562013357	Ribonuclease PH; Region: RNase_PH_bact; cd11362
1170562013358	hexamer interface [polypeptide binding]; other site
1170562013359	active site
1170562013360	Prokaryotic metallothionein; Region: Metallothio_Pro; pfam02069
1170562013361	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1170562013362	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1170562013363	DNA binding residues [nucleotide binding]
1170562013364	dimerization interface [polypeptide binding]; other site
1170562013365	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1170562013366	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
1170562013367	putative substrate binding site [chemical binding]; other site
1170562013368	putative ATP binding site [chemical binding]; other site
1170562013369	PAS domain; Region: PAS; smart00091
1170562013370	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1170562013371	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562013372	putative active site [active]
1170562013373	heme pocket [chemical binding]; other site
1170562013374	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
1170562013375	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1170562013376	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1170562013377	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1170562013378	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562013379	dimer interface [polypeptide binding]; other site
1170562013380	phosphorylation site [posttranslational modification]
1170562013381	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562013382	ATP binding site [chemical binding]; other site
1170562013383	Mg2+ binding site [ion binding]; other site
1170562013384	G-X-G motif; other site
1170562013385	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
1170562013386	NADPH bind site [chemical binding]; other site
1170562013387	putative FMN binding site [chemical binding]; other site
1170562013388	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
1170562013389	putative FMN binding site [chemical binding]; other site
1170562013390	NADPH bind site [chemical binding]; other site
1170562013391	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
1170562013392	putative nucleotide binding site [chemical binding]; other site
1170562013393	uridine monophosphate binding site [chemical binding]; other site
1170562013394	homohexameric interface [polypeptide binding]; other site
1170562013395	ribosome recycling factor; Reviewed; Region: frr; PRK00083
1170562013396	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
1170562013397	hinge region; other site
1170562013398	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
1170562013399	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1170562013400	AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250
1170562013401	succinate dehydrogenase iron-sulfur subunit; Provisional; Region: PRK12577
1170562013402	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
1170562013403	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1170562013404	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
1170562013405	beta propeller repeat, Methanosarcina surface protein type; Region: beta_prop_Msarc; TIGR04275
1170562013406	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
1170562013407	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1170562013408	Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444
1170562013409	Photosystem II reaction centre X protein (PsbX); Region: PsbX; pfam06596
1170562013410	Predicted integral membrane protein [Function unknown]; Region: COG0762
1170562013411	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
1170562013412	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1170562013413	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1170562013414	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1170562013415	Protein of unknown function (DUF98); Region: DUF98; pfam01947
1170562013416	Protein of unknown function (DUF3352); Region: DUF3352; pfam11832
1170562013417	cytochrome c biogenesis protein; Region: ccsA; CHL00045
1170562013418	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1170562013419	putative active site [active]
1170562013420	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
1170562013421	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562013422	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1170562013423	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562013424	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562013425	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562013426	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
1170562013427	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1170562013428	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1170562013429	Walker A/P-loop; other site
1170562013430	ATP binding site [chemical binding]; other site
1170562013431	Q-loop/lid; other site
1170562013432	ABC transporter signature motif; other site
1170562013433	Walker B; other site
1170562013434	D-loop; other site
1170562013435	H-loop/switch region; other site
1170562013436	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1170562013437	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1170562013438	dimer interface [polypeptide binding]; other site
1170562013439	conserved gate region; other site
1170562013440	putative PBP binding loops; other site
1170562013441	ABC-ATPase subunit interface; other site
1170562013442	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1170562013443	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1170562013444	dimer interface [polypeptide binding]; other site
1170562013445	conserved gate region; other site
1170562013446	putative PBP binding loops; other site
1170562013447	ABC-ATPase subunit interface; other site
1170562013448	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
1170562013449	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1170562013450	substrate binding pocket [chemical binding]; other site
1170562013451	membrane-bound complex binding site; other site
1170562013452	hinge residues; other site
1170562013453	ribosomal protein S14; Region: rps14; CHL00074
1170562013454	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
1170562013455	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1170562013456	minor groove reading motif; other site
1170562013457	helix-hairpin-helix signature motif; other site
1170562013458	substrate binding pocket [chemical binding]; other site
1170562013459	active site
1170562013460	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
1170562013461	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
1170562013462	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1170562013463	active site
1170562013464	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1170562013465	protein binding site [polypeptide binding]; other site
1170562013466	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
1170562013467	putative substrate binding region [chemical binding]; other site
1170562013468	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1170562013469	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1170562013470	putative active site [active]
1170562013471	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
1170562013472	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
1170562013473	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
1170562013474	metal binding site [ion binding]; metal-binding site
1170562013475	ChaB; Region: ChaB; cl01887
1170562013476	glutamate-1-semialdehyde 2,1-aminomutase; Region: PLN02482
1170562013477	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1170562013478	inhibitor-cofactor binding pocket; inhibition site
1170562013479	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1170562013480	catalytic residue [active]
1170562013481	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cd01635
1170562013482	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1170562013483	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1170562013484	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
1170562013485	aromatic arch; other site
1170562013486	DCoH dimer interaction site [polypeptide binding]; other site
1170562013487	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
1170562013488	DCoH tetramer interaction site [polypeptide binding]; other site
1170562013489	substrate binding site [chemical binding]; other site
1170562013490	S-layer homology domain; Region: SLH; pfam00395
1170562013491	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
1170562013492	Predicted transcriptional regulator [Transcription]; Region: COG1959
1170562013493	Transcriptional regulator; Region: Rrf2; pfam02082
1170562013494	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1170562013495	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1170562013496	dimer interface [polypeptide binding]; other site
1170562013497	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1170562013498	catalytic residue [active]
1170562013499	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
1170562013500	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1170562013501	HSP70 interaction site [polypeptide binding]; other site
1170562013502	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1170562013503	Domain of unknown function (DUF1824); Region: DUF1824; pfam08854
1170562013504	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1170562013505	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1170562013506	Walker A/P-loop; other site
1170562013507	ATP binding site [chemical binding]; other site
1170562013508	Q-loop/lid; other site
1170562013509	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1170562013510	ABC transporter signature motif; other site
1170562013511	Walker B; other site
1170562013512	D-loop; other site
1170562013513	ABC transporter; Region: ABC_tran_2; pfam12848
1170562013514	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1170562013515	HEAT repeats; Region: HEAT_2; pfam13646
1170562013516	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
1170562013517	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500
1170562013518	protein binding surface [polypeptide binding]; other site
1170562013519	HEAT repeats; Region: HEAT_2; pfam13646
1170562013520	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
1170562013521	Protein kinase domain; Region: Pkinase; pfam00069
1170562013522	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1170562013523	active site
1170562013524	ATP binding site [chemical binding]; other site
1170562013525	substrate binding site [chemical binding]; other site
1170562013526	activation loop (A-loop); other site
1170562013527	TPR repeat; Region: TPR_11; pfam13414
1170562013528	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562013529	binding surface
1170562013530	TPR motif; other site
1170562013531	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
1170562013532	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562013533	binding surface
1170562013534	TPR motif; other site
1170562013535	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562013536	binding surface
1170562013537	TPR motif; other site
1170562013538	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562013539	binding surface
1170562013540	TPR motif; other site
1170562013541	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1170562013542	S-adenosylmethionine binding site [chemical binding]; other site
1170562013543	Cache domain; Region: Cache_1; pfam02743
1170562013544	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1170562013545	dimerization interface [polypeptide binding]; other site
1170562013546	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1170562013547	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1170562013548	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1170562013549	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1170562013550	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1170562013551	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1170562013552	dimer interface [polypeptide binding]; other site
1170562013553	putative CheW interface [polypeptide binding]; other site
1170562013554	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562013555	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562013556	active site
1170562013557	phosphorylation site [posttranslational modification]
1170562013558	intermolecular recognition site; other site
1170562013559	dimerization interface [polypeptide binding]; other site
1170562013560	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
1170562013561	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1170562013562	RNA binding surface [nucleotide binding]; other site
1170562013563	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1170562013564	active site
1170562013565	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1170562013566	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1170562013567	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
1170562013568	active site
1170562013569	SAM binding site [chemical binding]; other site
1170562013570	homodimer interface [polypeptide binding]; other site
1170562013571	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1170562013572	putative active site [active]
1170562013573	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
1170562013574	adaptive-response sensory kinase; Validated; Region: PRK09303
1170562013575	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
1170562013576	tetramer interface [polypeptide binding]; other site
1170562013577	dimer interface [polypeptide binding]; other site
1170562013578	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562013579	dimer interface [polypeptide binding]; other site
1170562013580	phosphorylation site [posttranslational modification]
1170562013581	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562013582	ATP binding site [chemical binding]; other site
1170562013583	Mg2+ binding site [ion binding]; other site
1170562013584	G-X-G motif; other site
1170562013585	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1170562013586	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1170562013587	hinge; other site
1170562013588	active site
1170562013589	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
1170562013590	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1170562013591	HIGH motif; other site
1170562013592	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1170562013593	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1170562013594	active site
1170562013595	KMSKS motif; other site
1170562013596	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
1170562013597	tRNA binding surface [nucleotide binding]; other site
1170562013598	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
1170562013599	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
1170562013600	phosphate binding site [ion binding]; other site
1170562013601	putative substrate binding pocket [chemical binding]; other site
1170562013602	dimer interface [polypeptide binding]; other site
1170562013603	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
1170562013604	active site
1170562013605	putative DNA-binding cleft [nucleotide binding]; other site
1170562013606	dimer interface [polypeptide binding]; other site
1170562013607	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562013608	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562013609	active site
1170562013610	phosphorylation site [posttranslational modification]
1170562013611	intermolecular recognition site; other site
1170562013612	dimerization interface [polypeptide binding]; other site
1170562013613	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1170562013614	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562013615	dimer interface [polypeptide binding]; other site
1170562013616	phosphorylation site [posttranslational modification]
1170562013617	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562013618	ATP binding site [chemical binding]; other site
1170562013619	Mg2+ binding site [ion binding]; other site
1170562013620	G-X-G motif; other site
1170562013621	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
1170562013622	Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136
1170562013623	NAD(P) binding site [chemical binding]; other site
1170562013624	catalytic residues [active]
1170562013625	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
1170562013626	heterotetramer interface [polypeptide binding]; other site
1170562013627	active site pocket [active]
1170562013628	cleavage site
1170562013629	CsbD-like; Region: CsbD; pfam05532
1170562013630	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237
1170562013631	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237
1170562013632	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1170562013633	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
1170562013634	putative C-terminal domain interface [polypeptide binding]; other site
1170562013635	putative GSH binding site (G-site) [chemical binding]; other site
1170562013636	putative dimer interface [polypeptide binding]; other site
1170562013637	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
1170562013638	substrate binding pocket (H-site) [chemical binding]; other site
1170562013639	N-terminal domain interface [polypeptide binding]; other site
1170562013640	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562013641	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562013642	binding surface
1170562013643	TPR motif; other site
1170562013644	TPR repeat; Region: TPR_11; pfam13414
1170562013645	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562013646	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1170562013647	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1170562013648	active site
1170562013649	ATP binding site [chemical binding]; other site
1170562013650	substrate binding site [chemical binding]; other site
1170562013651	activation loop (A-loop); other site
1170562013652	FOG: WD40 repeat [General function prediction only]; Region: COG2319
1170562013653	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
1170562013654	structural tetrad; other site
1170562013655	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1170562013656	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1170562013657	active site
1170562013658	ATP binding site [chemical binding]; other site
1170562013659	substrate binding site [chemical binding]; other site
1170562013660	activation loop (A-loop); other site
1170562013661	Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449
1170562013662	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
1170562013663	N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796
1170562013664	putative active site [active]
1170562013665	catalytic site [active]
1170562013666	NifU-like domain; Region: NifU; pfam01106
1170562013667	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
1170562013668	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1170562013669	putative active site [active]
1170562013670	heme pocket [chemical binding]; other site
1170562013671	GAF domain; Region: GAF; pfam01590
1170562013672	Phytochrome region; Region: PHY; pfam00360
1170562013673	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562013674	dimer interface [polypeptide binding]; other site
1170562013675	phosphorylation site [posttranslational modification]
1170562013676	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562013677	ATP binding site [chemical binding]; other site
1170562013678	Mg2+ binding site [ion binding]; other site
1170562013679	G-X-G motif; other site
1170562013680	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1170562013681	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562013682	active site
1170562013683	phosphorylation site [posttranslational modification]
1170562013684	intermolecular recognition site; other site
1170562013685	dimerization interface [polypeptide binding]; other site
1170562013686	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562013687	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562013688	active site
1170562013689	phosphorylation site [posttranslational modification]
1170562013690	intermolecular recognition site; other site
1170562013691	dimerization interface [polypeptide binding]; other site
1170562013692	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1170562013693	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1170562013694	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562013695	heme pocket [chemical binding]; other site
1170562013696	putative active site [active]
1170562013697	PAS fold; Region: PAS_4; pfam08448
1170562013698	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562013699	putative active site [active]
1170562013700	heme pocket [chemical binding]; other site
1170562013701	PAS fold; Region: PAS_4; pfam08448
1170562013702	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
1170562013703	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1170562013704	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562013705	putative active site [active]
1170562013706	heme pocket [chemical binding]; other site
1170562013707	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562013708	dimer interface [polypeptide binding]; other site
1170562013709	phosphorylation site [posttranslational modification]
1170562013710	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562013711	ATP binding site [chemical binding]; other site
1170562013712	Mg2+ binding site [ion binding]; other site
1170562013713	G-X-G motif; other site
1170562013714	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1170562013715	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562013716	active site
1170562013717	phosphorylation site [posttranslational modification]
1170562013718	intermolecular recognition site; other site
1170562013719	dimerization interface [polypeptide binding]; other site
1170562013720	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1170562013721	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
1170562013722	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1170562013723	EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438
1170562013724	DXD motif; other site
1170562013725	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1170562013726	deoxyribodipyrimidine photo-lyase, 8-HDF type; Region: photolyase_8HDF; TIGR03556
1170562013727	DNA photolyase; Region: DNA_photolyase; pfam00875
1170562013728	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1170562013729	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
1170562013730	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1170562013731	catalytic residue [active]
1170562013732	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
1170562013733	FeS assembly protein SufD; Region: sufD; TIGR01981
1170562013734	sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131
1170562013735	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
1170562013736	Walker A/P-loop; other site
1170562013737	ATP binding site [chemical binding]; other site
1170562013738	Q-loop/lid; other site
1170562013739	ABC transporter signature motif; other site
1170562013740	Walker B; other site
1170562013741	D-loop; other site
1170562013742	H-loop/switch region; other site
1170562013743	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
1170562013744	putative ABC transporter; Region: ycf24; CHL00085
1170562013745	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1170562013746	iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702
1170562013747	putative DNA binding site [nucleotide binding]; other site
1170562013748	putative Zn2+ binding site [ion binding]; other site
1170562013749	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
1170562013750	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
1170562013751	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
1170562013752	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
1170562013753	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
1170562013754	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
1170562013755	MOSC domain; Region: MOSC; pfam03473
1170562013756	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1170562013757	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1170562013758	Catalytic site [active]
1170562013759	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1170562013760	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1170562013761	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1170562013762	Catalytic site [active]
1170562013763	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1170562013764	dihydroorotase; Provisional; Region: PRK07575
1170562013765	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1170562013766	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
1170562013767	active site
1170562013768	HEAT repeats; Region: HEAT_2; pfam13646
1170562013769	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020
1170562013770	protein binding surface [polypeptide binding]; other site
1170562013771	HEAT repeats; Region: HEAT_2; pfam13646
1170562013772	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
1170562013773	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1170562013774	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1170562013775	Walker A motif; other site
1170562013776	ATP binding site [chemical binding]; other site
1170562013777	Walker B motif; other site
1170562013778	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
1170562013779	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1170562013780	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1170562013781	Protein of unknown function (DUF2281); Region: DUF2281; cl02355
1170562013782	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
1170562013783	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1170562013784	classical (c) SDRs; Region: SDR_c; cd05233
1170562013785	NAD(P) binding site [chemical binding]; other site
1170562013786	active site
1170562013787	EamA-like transporter family; Region: EamA; pfam00892
1170562013788	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
1170562013789	Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188
1170562013790	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1170562013791	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1170562013792	nudix motif; other site
1170562013793	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1170562013794	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
1170562013795	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1170562013796	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1170562013797	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1170562013798	DNA binding residues [nucleotide binding]
1170562013799	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
1170562013800	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1170562013801	ATP binding site [chemical binding]; other site
1170562013802	putative Mg++ binding site [ion binding]; other site
1170562013803	helicase superfamily c-terminal domain; Region: HELICc; smart00490
1170562013804	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
1170562013805	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
1170562013806	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1170562013807	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1170562013808	K+-transporting ATPase, c chain; Region: KdpC; cl00944
1170562013809	4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK02746
1170562013810	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
1170562013811	Ycf39; Provisional; Region: ycf39; CHL00194
1170562013812	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
1170562013813	NAD(P) binding site [chemical binding]; other site
1170562013814	putative active site [active]
1170562013815	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02649
1170562013816	ATP-NAD kinase; Region: NAD_kinase; pfam01513
1170562013817	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1170562013818	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562013819	active site
1170562013820	phosphorylation site [posttranslational modification]
1170562013821	intermolecular recognition site; other site
1170562013822	dimerization interface [polypeptide binding]; other site
1170562013823	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1170562013824	DNA binding site [nucleotide binding]
1170562013825	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
1170562013826	Protein of unknown function (DUF2949); Region: DUF2949; pfam11165
1170562013827	DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185
1170562013828	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1170562013829	Walker A/P-loop; other site
1170562013830	ATP binding site [chemical binding]; other site
1170562013831	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1170562013832	ABC transporter signature motif; other site
1170562013833	Walker B; other site
1170562013834	D-loop; other site
1170562013835	H-loop/switch region; other site
1170562013836	hypothetical protein; Provisional; Region: PRK06850
1170562013837	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1170562013838	Active Sites [active]
1170562013839	DGQHR domain; Region: DGQHR; TIGR03187
1170562013840	DNA-sulfur modification-associated; Region: DndB; cl17621
1170562013841	dnd system-associated protein 4; Region: dnd_assoc_4; TIGR04062
1170562013842	DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185
1170562013843	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1170562013844	Walker A/P-loop; other site
1170562013845	ATP binding site [chemical binding]; other site
1170562013846	DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095
1170562013847	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1170562013848	ATP binding site [chemical binding]; other site
1170562013849	putative Mg++ binding site [ion binding]; other site
1170562013850	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1170562013851	nucleotide binding region [chemical binding]; other site
1170562013852	ATP-binding site [chemical binding]; other site
1170562013853	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
1170562013854	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
1170562013855	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1170562013856	Catalytic site [active]
1170562013857	ornithine carbamoyltransferase; Provisional; Region: PRK00779
1170562013858	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1170562013859	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1170562013860	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1170562013861	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1170562013862	Switch I region; other site
1170562013863	G3 box; other site
1170562013864	Switch II region; other site
1170562013865	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1170562013866	EamA-like transporter family; Region: EamA; pfam00892
1170562013867	heterocyst differentiation control protein; Reviewed; Region: hetR; PRK13245
1170562013868	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
1170562013869	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1170562013870	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
1170562013871	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
1170562013872	Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597
1170562013873	Putative transcription activator [Transcription]; Region: TenA; COG0819
1170562013874	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
1170562013875	Cysteine-rich domain; Region: CCG; pfam02754
1170562013876	Cysteine-rich domain; Region: CCG; pfam02754
1170562013877	acyl carrier protein; Provisional; Region: acpP; PRK00982
1170562013878	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
1170562013879	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1170562013880	dimer interface [polypeptide binding]; other site
1170562013881	active site
1170562013882	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1170562013883	transketolase; Region: PLN02790
1170562013884	TPP-binding site [chemical binding]; other site
1170562013885	dimer interface [polypeptide binding]; other site
1170562013886	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1170562013887	PYR/PP interface [polypeptide binding]; other site
1170562013888	dimer interface [polypeptide binding]; other site
1170562013889	TPP binding site [chemical binding]; other site
1170562013890	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1170562013891	PBP superfamily domain; Region: PBP_like_2; cl17296
1170562013892	glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955
1170562013893	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1170562013894	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1170562013895	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1170562013896	putative substrate translocation pore; other site
1170562013897	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1170562013898	carotene isomerase; Region: carot_isom; TIGR02730
1170562013899	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1170562013900	Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403
1170562013901	catalytic motif [active]
1170562013902	Catalytic residue [active]
1170562013903	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
1170562013904	AAA ATPase domain; Region: AAA_15; pfam13175
1170562013905	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
1170562013906	Walker B; other site
1170562013907	D-loop; other site
1170562013908	H-loop/switch region; other site
1170562013909	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1170562013910	active site
1170562013911	YGGT family; Region: YGGT; pfam02325
1170562013912	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
1170562013913	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1170562013914	GAF domain; Region: GAF; pfam01590
1170562013915	GAF domain; Region: GAF_2; pfam13185
1170562013916	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
1170562013917	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
1170562013918	active site
1170562013919	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
1170562013920	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
1170562013921	active site
1170562013922	(T/H)XGH motif; other site
1170562013923	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
1170562013924	nudix motif; other site
1170562013925	CAAX protease self-immunity; Region: Abi; pfam02517
1170562013926	Protein of unknown function (DUF3326); Region: DUF3326; pfam11805
1170562013927	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
1170562013928	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1170562013929	catalytic loop [active]
1170562013930	iron binding site [ion binding]; other site
1170562013931	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
1170562013932	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
1170562013933	substrate binding site [chemical binding]; other site
1170562013934	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
1170562013935	substrate binding site [chemical binding]; other site
1170562013936	ligand binding site [chemical binding]; other site
1170562013937	XisH protein; Region: XisH; pfam08814
1170562013938	XisI protein; Region: XisI; pfam08869
1170562013939	hypothetical protein; Validated; Region: PRK00110
1170562013940	dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377
1170562013941	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
1170562013942	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1170562013943	dimerization domain swap beta strand [polypeptide binding]; other site
1170562013944	regulatory protein interface [polypeptide binding]; other site
1170562013945	active site
1170562013946	regulatory phosphorylation site [posttranslational modification]; other site
1170562013947	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
1170562013948	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
1170562013949	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1170562013950	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1170562013951	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1170562013952	Cytochrome P450; Region: p450; cl12078
1170562013953	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
1170562013954	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1170562013955	active site
1170562013956	ATP binding site [chemical binding]; other site
1170562013957	substrate binding site [chemical binding]; other site
1170562013958	activation loop (A-loop); other site
1170562013959	Bacterial SH3 domain; Region: SH3_3; cl17532
1170562013960	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1170562013961	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1170562013962	Probable transposase; Region: OrfB_IS605; pfam01385
1170562013963	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
1170562013964	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791
1170562013965	Cupin domain; Region: Cupin_2; cl17218
1170562013966	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
1170562013967	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1170562013968	motif II; other site
1170562013969	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
1170562013970	intersubunit interface [polypeptide binding]; other site
1170562013971	active site
1170562013972	Zn2+ binding site [ion binding]; other site
1170562013973	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
1170562013974	hypothetical protein; Validated; Region: PRK07411
1170562013975	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
1170562013976	ATP binding site [chemical binding]; other site
1170562013977	substrate interface [chemical binding]; other site
1170562013978	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1170562013979	active site residue [active]
1170562013980	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
1170562013981	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
1170562013982	active site
1170562013983	homodimer interface [polypeptide binding]; other site
1170562013984	stage V sporulation protein K; Region: spore_V_K; TIGR02881
1170562013985	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1170562013986	Walker A motif; other site
1170562013987	ATP binding site [chemical binding]; other site
1170562013988	Walker B motif; other site
1170562013989	arginine finger; other site
1170562013990	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1170562013991	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1170562013992	ligand binding site [chemical binding]; other site
1170562013993	flexible hinge region; other site
1170562013994	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
1170562013995	Lumazine binding domain; Region: Lum_binding; pfam00677
1170562013996	Lumazine binding domain; Region: Lum_binding; pfam00677
1170562013997	Bifunctional nuclease; Region: DNase-RNase; pfam02577
1170562013998	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
1170562013999	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1170562014000	active site
1170562014001	catalytic tetrad [active]
1170562014002	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
1170562014003	DHH family; Region: DHH; pfam01368
1170562014004	DHHA1 domain; Region: DHHA1; pfam02272
1170562014005	Photosystem II complex subunit Ycf12; Region: PSII_Ycf12; cl12139
1170562014006	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
1170562014007	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
1170562014008	9,9'-di-cis-zeta-carotene desaturase; Region: zeta_caro_desat; TIGR02732
1170562014009	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1170562014010	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
1170562014011	putative hydrophobic ligand binding site [chemical binding]; other site
1170562014012	PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026
1170562014013	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxase_2; pfam12766
1170562014014	WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996
1170562014015	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
1170562014016	active site
1170562014017	Trp docking motif [polypeptide binding]; other site
1170562014018	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562014019	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562014020	active site
1170562014021	phosphorylation site [posttranslational modification]
1170562014022	intermolecular recognition site; other site
1170562014023	dimerization interface [polypeptide binding]; other site
1170562014024	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1170562014025	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562014026	active site
1170562014027	phosphorylation site [posttranslational modification]
1170562014028	intermolecular recognition site; other site
1170562014029	dimerization interface [polypeptide binding]; other site
1170562014030	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1170562014031	DNA binding site [nucleotide binding]
1170562014032	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1170562014033	putative binding surface; other site
1170562014034	active site
1170562014035	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562014036	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562014037	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562014038	active site
1170562014039	phosphorylation site [posttranslational modification]
1170562014040	intermolecular recognition site; other site
1170562014041	dimerization interface [polypeptide binding]; other site
1170562014042	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562014043	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1170562014044	putative active site [active]
1170562014045	heme pocket [chemical binding]; other site
1170562014046	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562014047	dimer interface [polypeptide binding]; other site
1170562014048	phosphorylation site [posttranslational modification]
1170562014049	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562014050	ATP binding site [chemical binding]; other site
1170562014051	Mg2+ binding site [ion binding]; other site
1170562014052	G-X-G motif; other site
1170562014053	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1170562014054	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562014055	active site
1170562014056	phosphorylation site [posttranslational modification]
1170562014057	intermolecular recognition site; other site
1170562014058	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562014059	active site
1170562014060	phosphorylation site [posttranslational modification]
1170562014061	intermolecular recognition site; other site
1170562014062	dimerization interface [polypeptide binding]; other site
1170562014063	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
1170562014064	proline aminopeptidase P II; Provisional; Region: PRK10879
1170562014065	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
1170562014066	active site
1170562014067	Family description; Region: VCBS; pfam13517
1170562014068	Family description; Region: VCBS; pfam13517
1170562014069	Family description; Region: VCBS; pfam13517
1170562014070	Family description; Region: VCBS; pfam13517
1170562014071	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
1170562014072	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1170562014073	Peptidase family U32; Region: Peptidase_U32; pfam01136
1170562014074	Collagenase; Region: DUF3656; pfam12392
1170562014075	Peptidase family U32; Region: Peptidase_U32; cl03113
1170562014076	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
1170562014077	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
1170562014078	active site
1170562014079	catalytic residues [active]
1170562014080	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1170562014081	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1170562014082	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1170562014083	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
1170562014084	CHAT domain; Region: CHAT; cl17868
1170562014085	CHASE2 domain; Region: CHASE2; cl01732
1170562014086	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
1170562014087	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
1170562014088	proposed catalytic triad [active]
1170562014089	active site nucleophile [active]
1170562014090	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1170562014091	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1170562014092	substrate binding pocket [chemical binding]; other site
1170562014093	membrane-bound complex binding site; other site
1170562014094	hinge residues; other site
1170562014095	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1170562014096	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1170562014097	dimer interface [polypeptide binding]; other site
1170562014098	conserved gate region; other site
1170562014099	putative PBP binding loops; other site
1170562014100	ABC-ATPase subunit interface; other site
1170562014101	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1170562014102	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1170562014103	Walker A/P-loop; other site
1170562014104	ATP binding site [chemical binding]; other site
1170562014105	Q-loop/lid; other site
1170562014106	ABC transporter signature motif; other site
1170562014107	Walker B; other site
1170562014108	D-loop; other site
1170562014109	H-loop/switch region; other site
1170562014110	bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625
1170562014111	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
1170562014112	active site
1170562014113	metal binding site [ion binding]; metal-binding site
1170562014114	Protein of unknown function (DUF2809); Region: DUF2809; pfam10990
1170562014115	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562014116	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562014117	active site
1170562014118	phosphorylation site [posttranslational modification]
1170562014119	intermolecular recognition site; other site
1170562014120	dimerization interface [polypeptide binding]; other site
1170562014121	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
1170562014122	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
1170562014123	fimbrial chaperone protein StbB; Provisional; Region: PRK15249
1170562014124	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
1170562014125	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
1170562014126	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1170562014127	polyphosphate kinase; Provisional; Region: PRK05443
1170562014128	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
1170562014129	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
1170562014130	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
1170562014131	putative domain interface [polypeptide binding]; other site
1170562014132	putative active site [active]
1170562014133	catalytic site [active]
1170562014134	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
1170562014135	putative domain interface [polypeptide binding]; other site
1170562014136	putative active site [active]
1170562014137	catalytic site [active]
1170562014138	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
1170562014139	nudix motif; other site
1170562014140	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1170562014141	homotrimer interaction site [polypeptide binding]; other site
1170562014142	putative active site [active]
1170562014143	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
1170562014144	active site
1170562014145	dimer interface [polypeptide binding]; other site
1170562014146	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
1170562014147	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
1170562014148	active site
1170562014149	HIGH motif; other site
1170562014150	dimer interface [polypeptide binding]; other site
1170562014151	KMSKS motif; other site
1170562014152	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
1170562014153	Transglycosylase; Region: Transgly; pfam00912
1170562014154	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
1170562014155	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1170562014156	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
1170562014157	ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682
1170562014158	putative Cl- selectivity filter; other site
1170562014159	putative pore gating glutamate residue; other site
1170562014160	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
1170562014161	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1170562014162	Ligand Binding Site [chemical binding]; other site
1170562014163	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1170562014164	anti sigma factor interaction site; other site
1170562014165	regulatory phosphorylation site [posttranslational modification]; other site
1170562014166	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
1170562014167	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
1170562014168	B12 binding site [chemical binding]; other site
1170562014169	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1170562014170	FeS/SAM binding site; other site
1170562014171	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5011
1170562014172	radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
1170562014173	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
1170562014174	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
1170562014175	homodimer interface [polypeptide binding]; other site
1170562014176	oligonucleotide binding site [chemical binding]; other site
1170562014177	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
1170562014178	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
1170562014179	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
1170562014180	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
1170562014181	CpcD/allophycocyanin linker domain; Region: CpcD; pfam01383
1170562014182	phycocyanin, alpha subunit; Region: phycocy_alpha; TIGR01338
1170562014183	phycocyanin, beta subunit; Region: phycocy_beta; TIGR01339
1170562014184	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1170562014185	active site
1170562014186	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562014187	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562014188	binding surface
1170562014189	TPR motif; other site
1170562014190	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562014191	binding surface
1170562014192	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562014193	TPR motif; other site
1170562014194	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562014195	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1170562014196	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562014197	dimer interface [polypeptide binding]; other site
1170562014198	phosphorylation site [posttranslational modification]
1170562014199	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562014200	ATP binding site [chemical binding]; other site
1170562014201	Mg2+ binding site [ion binding]; other site
1170562014202	G-X-G motif; other site
1170562014203	Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345
1170562014204	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
1170562014205	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1170562014206	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
1170562014207	putative catalytic site [active]
1170562014208	putative metal binding site [ion binding]; other site
1170562014209	putative phosphate binding site [ion binding]; other site
1170562014210	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1170562014211	putative active site [active]
1170562014212	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
1170562014213	XisI protein; Region: XisI; pfam08869
1170562014214	XisH protein; Region: XisH; pfam08814
1170562014215	Protein kinase domain; Region: Pkinase; pfam00069
1170562014216	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1170562014217	active site
1170562014218	ATP binding site [chemical binding]; other site
1170562014219	substrate binding site [chemical binding]; other site
1170562014220	activation loop (A-loop); other site
1170562014221	GUN4-like; Region: GUN4; pfam05419
1170562014222	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1170562014223	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1170562014224	active site
1170562014225	ATP binding site [chemical binding]; other site
1170562014226	substrate binding site [chemical binding]; other site
1170562014227	activation loop (A-loop); other site
1170562014228	4-alpha-glucanotransferase; Provisional; Region: PRK14508
1170562014229	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
1170562014230	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
1170562014231	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1170562014232	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
1170562014233	Helix-turn-helix domain; Region: HTH_25; pfam13413
1170562014234	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
1170562014235	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1170562014236	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1170562014237	RNA binding surface [nucleotide binding]; other site
1170562014238	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
1170562014239	active site
1170562014240	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
1170562014241	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
1170562014242	phosphatidate cytidylyltransferase; Region: PLN02953
1170562014243	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
1170562014244	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1170562014245	S-adenosylmethionine binding site [chemical binding]; other site
1170562014246	Type IV pilin PilA; Region: Pilin_PilA; pfam14245
1170562014247	Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826
1170562014248	cyanophycin synthetase; Region: cya_phycin_syn; TIGR02068
1170562014249	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
1170562014250	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1170562014251	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1170562014252	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
1170562014253	proposed catalytic triad [active]
1170562014254	active site nucleophile [active]
1170562014255	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
1170562014256	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
1170562014257	homotrimer interaction site [polypeptide binding]; other site
1170562014258	zinc binding site [ion binding]; other site
1170562014259	CDP-binding sites; other site
1170562014260	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1170562014261	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500
1170562014262	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
1170562014263	AIR carboxylase; Region: AIRC; smart01001
1170562014264	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1170562014265	active site
1170562014266	metal binding site [ion binding]; metal-binding site
1170562014267	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
1170562014268	Fatty acid desaturase; Region: FA_desaturase; pfam00487
1170562014269	Di-iron ligands [ion binding]; other site
1170562014270	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
1170562014271	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
1170562014272	putative NADP binding site [chemical binding]; other site
1170562014273	putative substrate binding site [chemical binding]; other site
1170562014274	active site
1170562014275	MAPEG family; Region: MAPEG; pfam01124
1170562014276	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1170562014277	active site
1170562014278	DNA binding site [nucleotide binding]
1170562014279	Domain of unknown function (DUF3598); Region: DUF3598; pfam12204
1170562014280	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
1170562014281	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
1170562014282	FtsX-like permease family; Region: FtsX; pfam02687
1170562014283	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1170562014284	active site
1170562014285	catalytic residues [active]
1170562014286	metal binding site [ion binding]; metal-binding site
1170562014287	Domain of unknown function (DUF1768); Region: DUF1768; pfam08719
1170562014288	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5255
1170562014289	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
1170562014290	MltA specific insert domain; Region: MltA; pfam03562
1170562014291	3D domain; Region: 3D; pfam06725
1170562014292	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1170562014293	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
1170562014294	dimer interface [polypeptide binding]; other site
1170562014295	phosphorylation site [posttranslational modification]
1170562014296	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562014297	ATP binding site [chemical binding]; other site
1170562014298	Mg2+ binding site [ion binding]; other site
1170562014299	G-X-G motif; other site
1170562014300	Domain of unknown function (DUF1818); Region: DUF1818; pfam08848
1170562014301	DNA-directed RNA polymerase subunit omega; Provisional; Region: ycf61; CHL00191
1170562014302	ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887
1170562014303	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
1170562014304	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1170562014305	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
1170562014306	putative NAD(P) binding site [chemical binding]; other site
1170562014307	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1170562014308	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1170562014309	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1170562014310	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1170562014311	Walker A/P-loop; other site
1170562014312	ATP binding site [chemical binding]; other site
1170562014313	Q-loop/lid; other site
1170562014314	ABC transporter signature motif; other site
1170562014315	Walker B; other site
1170562014316	D-loop; other site
1170562014317	H-loop/switch region; other site
1170562014318	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1170562014319	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
1170562014320	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1170562014321	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1170562014322	active site
1170562014323	ATP binding site [chemical binding]; other site
1170562014324	substrate binding site [chemical binding]; other site
1170562014325	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1170562014326	substrate binding site [chemical binding]; other site
1170562014327	activation loop (A-loop); other site
1170562014328	activation loop (A-loop); other site
1170562014329	AAA ATPase domain; Region: AAA_16; pfam13191
1170562014330	Predicted ATPase [General function prediction only]; Region: COG3899
1170562014331	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1170562014332	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1170562014333	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1170562014334	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562014335	ATP binding site [chemical binding]; other site
1170562014336	Mg2+ binding site [ion binding]; other site
1170562014337	G-X-G motif; other site
1170562014338	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562014339	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562014340	active site
1170562014341	phosphorylation site [posttranslational modification]
1170562014342	intermolecular recognition site; other site
1170562014343	dimerization interface [polypeptide binding]; other site
1170562014344	Chorismate mutase type II; Region: CM_2; cl00693
1170562014345	lipoyl synthase; Provisional; Region: PRK12928
1170562014346	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1170562014347	FeS/SAM binding site; other site
1170562014348	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1170562014349	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562014350	dimer interface [polypeptide binding]; other site
1170562014351	phosphorylation site [posttranslational modification]
1170562014352	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562014353	ATP binding site [chemical binding]; other site
1170562014354	Mg2+ binding site [ion binding]; other site
1170562014355	G-X-G motif; other site
1170562014356	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1170562014357	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562014358	active site
1170562014359	phosphorylation site [posttranslational modification]
1170562014360	intermolecular recognition site; other site
1170562014361	dimerization interface [polypeptide binding]; other site
1170562014362	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
1170562014363	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
1170562014364	Ligand Binding Site [chemical binding]; other site
1170562014365	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
1170562014366	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
1170562014367	putative active site [active]
1170562014368	putative metal binding site [ion binding]; other site
1170562014369	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1170562014370	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1170562014371	active site
1170562014372	catalytic tetrad [active]
1170562014373	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1170562014374	dimerization interface [polypeptide binding]; other site
1170562014375	putative DNA binding site [nucleotide binding]; other site
1170562014376	putative Zn2+ binding site [ion binding]; other site
1170562014377	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
1170562014378	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1170562014379	dimerization interface [polypeptide binding]; other site
1170562014380	PAS domain; Region: PAS; smart00091
1170562014381	putative active site [active]
1170562014382	heme pocket [chemical binding]; other site
1170562014383	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562014384	dimer interface [polypeptide binding]; other site
1170562014385	phosphorylation site [posttranslational modification]
1170562014386	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562014387	ATP binding site [chemical binding]; other site
1170562014388	Mg2+ binding site [ion binding]; other site
1170562014389	G-X-G motif; other site
1170562014390	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
1170562014391	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1170562014392	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1170562014393	protein binding site [polypeptide binding]; other site
1170562014394	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
1170562014395	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
1170562014396	DDE superfamily endonuclease; Region: DDE_5; cl17874
1170562014397	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1170562014398	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
1170562014399	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
1170562014400	dimerization interface [polypeptide binding]; other site
1170562014401	domain crossover interface; other site
1170562014402	redox-dependent activation switch; other site
1170562014403	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
1170562014404	AAA domain; Region: AAA_33; pfam13671
1170562014405	ATP-binding site [chemical binding]; other site
1170562014406	Gluconate-6-phosphate binding site [chemical binding]; other site
1170562014407	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
1170562014408	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1170562014409	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
1170562014410	NodB motif; other site
1170562014411	active site
1170562014412	catalytic site [active]
1170562014413	metal binding site [ion binding]; metal-binding site
1170562014414	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1170562014415	GAF domain; Region: GAF; pfam01590
1170562014416	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1170562014417	GAF domain; Region: GAF; pfam01590
1170562014418	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1170562014419	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562014420	dimer interface [polypeptide binding]; other site
1170562014421	phosphorylation site [posttranslational modification]
1170562014422	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562014423	ATP binding site [chemical binding]; other site
1170562014424	Mg2+ binding site [ion binding]; other site
1170562014425	G-X-G motif; other site
1170562014426	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_11; cd08866
1170562014427	putative hydrophobic ligand binding site [chemical binding]; other site
1170562014428	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
1170562014429	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
1170562014430	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1170562014431	TrkA-N domain; Region: TrkA_N; pfam02254
1170562014432	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
1170562014433	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1170562014434	Walker A/P-loop; other site
1170562014435	ATP binding site [chemical binding]; other site
1170562014436	Q-loop/lid; other site
1170562014437	ABC transporter signature motif; other site
1170562014438	Walker B; other site
1170562014439	D-loop; other site
1170562014440	H-loop/switch region; other site
1170562014441	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
1170562014442	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
1170562014443	PQQ-like domain; Region: PQQ_2; pfam13360
1170562014444	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
1170562014445	Ca2+ binding site [ion binding]; other site
1170562014446	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
1170562014447	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
1170562014448	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
1170562014449	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
1170562014450	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
1170562014451	delta-60 repeat domain; Region: delta_60_rpt; TIGR02608
1170562014452	Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967
1170562014453	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1170562014454	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562014455	active site
1170562014456	phosphorylation site [posttranslational modification]
1170562014457	intermolecular recognition site; other site
1170562014458	dimerization interface [polypeptide binding]; other site
1170562014459	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1170562014460	DNA binding site [nucleotide binding]
1170562014461	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1170562014462	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1170562014463	S-adenosylmethionine binding site [chemical binding]; other site
1170562014464	Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073
1170562014465	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
1170562014466	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
1170562014467	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
1170562014468	active site
1170562014469	SAM binding site [chemical binding]; other site
1170562014470	homodimer interface [polypeptide binding]; other site
1170562014471	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
1170562014472	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1170562014473	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1170562014474	NAD(P) binding site [chemical binding]; other site
1170562014475	Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547
1170562014476	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1170562014477	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1170562014478	NAD(P) binding site [chemical binding]; other site
1170562014479	active site
1170562014480	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
1170562014481	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1170562014482	N-terminal plug; other site
1170562014483	ligand-binding site [chemical binding]; other site
1170562014484	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
1170562014485	dimer interface [polypeptide binding]; other site
1170562014486	[2Fe-2S] cluster binding site [ion binding]; other site
1170562014487	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1170562014488	Periplasmic binding protein TroA_d.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141
1170562014489	putative ligand binding site [chemical binding]; other site
1170562014490	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1170562014491	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1170562014492	ABC-ATPase subunit  interface; other site
1170562014493	dimer interface [polypeptide binding]; other site
1170562014494	putative PBP binding regions; other site
1170562014495	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562014496	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562014497	active site
1170562014498	phosphorylation site [posttranslational modification]
1170562014499	intermolecular recognition site; other site
1170562014500	dimerization interface [polypeptide binding]; other site
1170562014501	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1170562014502	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1170562014503	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1170562014504	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1170562014505	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1170562014506	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562014507	dimer interface [polypeptide binding]; other site
1170562014508	phosphorylation site [posttranslational modification]
1170562014509	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562014510	ATP binding site [chemical binding]; other site
1170562014511	Mg2+ binding site [ion binding]; other site
1170562014512	G-X-G motif; other site
1170562014513	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562014514	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562014515	active site
1170562014516	phosphorylation site [posttranslational modification]
1170562014517	intermolecular recognition site; other site
1170562014518	dimerization interface [polypeptide binding]; other site
1170562014519	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1170562014520	cyclase homology domain; Region: CHD; cd07302
1170562014521	nucleotidyl binding site; other site
1170562014522	metal binding site [ion binding]; metal-binding site
1170562014523	dimer interface [polypeptide binding]; other site
1170562014524	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1170562014525	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1170562014526	Coenzyme A binding pocket [chemical binding]; other site
1170562014527	histidinol-phosphate aminotransferase; Provisional; Region: PRK02610
1170562014528	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1170562014529	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1170562014530	homodimer interface [polypeptide binding]; other site
1170562014531	catalytic residue [active]
1170562014532	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
1170562014533	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1170562014534	glutathione reductase; Validated; Region: PRK06116
1170562014535	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
1170562014536	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1170562014537	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1170562014538	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
1170562014539	catalytic motif [active]
1170562014540	Catalytic residue [active]
1170562014541	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
1170562014542	catalytic motif [active]
1170562014543	Catalytic residue [active]
1170562014544	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
1170562014545	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
1170562014546	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
1170562014547	putative dimer interface [polypeptide binding]; other site
1170562014548	N-terminal domain interface [polypeptide binding]; other site
1170562014549	putative substrate binding pocket (H-site) [chemical binding]; other site
1170562014550	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1170562014551	binding surface
1170562014552	TPR motif; other site
1170562014553	TPR repeat; Region: TPR_11; pfam13414
1170562014554	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562014555	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562014556	binding surface
1170562014557	TPR motif; other site
1170562014558	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562014559	binding surface
1170562014560	TPR motif; other site
1170562014561	CHAT domain; Region: CHAT; pfam12770
1170562014562	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
1170562014563	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
1170562014564	active site
1170562014565	Substrate binding site; other site
1170562014566	Mg++ binding site; other site
1170562014567	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1170562014568	putative CoA binding site [chemical binding]; other site
1170562014569	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
1170562014570	GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity.  The protein contains an...; Region: MPG1_transferase; cd05805
1170562014571	YciI-like protein; Reviewed; Region: PRK12864
1170562014572	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
1170562014573	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1170562014574	putative tRNA-binding site [nucleotide binding]; other site
1170562014575	B3/4 domain; Region: B3_4; pfam03483
1170562014576	tRNA synthetase B5 domain; Region: B5; smart00874
1170562014577	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
1170562014578	dimer interface [polypeptide binding]; other site
1170562014579	motif 1; other site
1170562014580	motif 3; other site
1170562014581	motif 2; other site
1170562014582	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
1170562014583	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
1170562014584	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
1170562014585	Phytochelatin synthase; Region: Phytochelatin; pfam05023
1170562014586	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
1170562014587	Protein of unknown function (DUF1565); Region: DUF1565; pfam07602
1170562014588	S-layer homology domain; Region: SLH; pfam00395
1170562014589	S-layer homology domain; Region: SLH; pfam00395
1170562014590	S-layer homology domain; Region: SLH; pfam00395
1170562014591	S-layer homology domain; Region: SLH; pfam00395
1170562014592	DAK2 domain; Region: Dak2; cl03685
1170562014593	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
1170562014594	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
1170562014595	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1170562014596	active site
1170562014597	catalytic residues [active]
1170562014598	metal binding site [ion binding]; metal-binding site
1170562014599	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
1170562014600	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259
1170562014601	putative active site [active]
1170562014602	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1170562014603	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1170562014604	Walker A/P-loop; other site
1170562014605	ATP binding site [chemical binding]; other site
1170562014606	Q-loop/lid; other site
1170562014607	ABC transporter signature motif; other site
1170562014608	Walker B; other site
1170562014609	D-loop; other site
1170562014610	H-loop/switch region; other site
1170562014611	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
1170562014612	Integral membrane protein DUF92; Region: DUF92; pfam01940
1170562014613	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
1170562014614	active site
1170562014615	catalytic residues [active]
1170562014616	Domain of unknown function (DUF4359); Region: DUF4359; pfam14271
1170562014617	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562014618	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562014619	active site
1170562014620	phosphorylation site [posttranslational modification]
1170562014621	intermolecular recognition site; other site
1170562014622	dimerization interface [polypeptide binding]; other site
1170562014623	Protein of unknown function (DUF3685); Region: DUF3685; pfam12452
1170562014624	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1170562014625	Amidase; Region: Amidase; pfam01425
1170562014626	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
1170562014627	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
1170562014628	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
1170562014629	Double zinc ribbon; Region: DZR; pfam12773
1170562014630	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1170562014631	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1170562014632	active site
1170562014633	ATP binding site [chemical binding]; other site
1170562014634	substrate binding site [chemical binding]; other site
1170562014635	activation loop (A-loop); other site
1170562014636	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1170562014637	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1170562014638	active site
1170562014639	ATP binding site [chemical binding]; other site
1170562014640	substrate binding site [chemical binding]; other site
1170562014641	activation loop (A-loop); other site
1170562014642	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396
1170562014643	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
1170562014644	Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099
1170562014645	NAD(P) binding site [chemical binding]; other site
1170562014646	catalytic residues [active]
1170562014647	TIGR02588 family protein; Region: TIGR02588
1170562014648	Putative integral membrane protein (DUF2391); Region: DUF2391; pfam09622
1170562014649	RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980
1170562014650	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1170562014651	DNA binding residues [nucleotide binding]
1170562014652	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
1170562014653	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1170562014654	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1170562014655	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1170562014656	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1170562014657	catalytic residues [active]
1170562014658	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649
1170562014659	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1170562014660	active site
1170562014661	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
1170562014662	MutS domain III; Region: MutS_III; pfam05192
1170562014663	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1170562014664	Walker A/P-loop; other site
1170562014665	ATP binding site [chemical binding]; other site
1170562014666	Q-loop/lid; other site
1170562014667	ABC transporter signature motif; other site
1170562014668	Walker B; other site
1170562014669	D-loop; other site
1170562014670	H-loop/switch region; other site
1170562014671	Smr domain; Region: Smr; pfam01713
1170562014672	Rubrerythrin [Energy production and conversion]; Region: COG1592
1170562014673	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
1170562014674	binuclear metal center [ion binding]; other site
1170562014675	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
1170562014676	iron binding site [ion binding]; other site
1170562014677	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
1170562014678	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
1170562014679	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1170562014680	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
1170562014681	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
1170562014682	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
1170562014683	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
1170562014684	substrate binding site [chemical binding]; other site
1170562014685	catalytic Zn binding site [ion binding]; other site
1170562014686	NAD binding site [chemical binding]; other site
1170562014687	structural Zn binding site [ion binding]; other site
1170562014688	dimer interface [polypeptide binding]; other site
1170562014689	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1170562014690	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1170562014691	HlyD family secretion protein; Region: HlyD_3; pfam13437
1170562014692	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1170562014693	FtsX-like permease family; Region: FtsX; pfam02687
1170562014694	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1170562014695	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1170562014696	Walker A/P-loop; other site
1170562014697	ATP binding site [chemical binding]; other site
1170562014698	Q-loop/lid; other site
1170562014699	ABC transporter signature motif; other site
1170562014700	Walker B; other site
1170562014701	D-loop; other site
1170562014702	H-loop/switch region; other site
1170562014703	Bacterial SH3 domain homologues; Region: SH3b; smart00287
1170562014704	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
1170562014705	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1170562014706	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1170562014707	active site
1170562014708	ATP binding site [chemical binding]; other site
1170562014709	substrate binding site [chemical binding]; other site
1170562014710	activation loop (A-loop); other site
1170562014711	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
1170562014712	Transglycosylase; Region: Transgly; pfam00912
1170562014713	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
1170562014714	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1170562014715	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
1170562014716	catalytic center binding site [active]
1170562014717	ATP binding site [chemical binding]; other site
1170562014718	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
1170562014719	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1170562014720	dimer interface [polypeptide binding]; other site
1170562014721	ADP-ribose binding site [chemical binding]; other site
1170562014722	active site
1170562014723	nudix motif; other site
1170562014724	metal binding site [ion binding]; metal-binding site
1170562014725	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1170562014726	putative active site [active]
1170562014727	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562014728	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562014729	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562014730	binding surface
1170562014731	TPR motif; other site
1170562014732	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1170562014733	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562014734	binding surface
1170562014735	TPR motif; other site
1170562014736	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1170562014737	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1170562014738	active site
1170562014739	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
1170562014740	Fe-S cluster binding site [ion binding]; other site
1170562014741	active site
1170562014742	sialate_O-acetylesterase_like subfamily of the SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: sialate_O-acetylesterase_like2; cd01828
1170562014743	active site
1170562014744	catalytic triad [active]
1170562014745	oxyanion hole [active]
1170562014746	Domain of unknown function (DUF1823); Region: DUF1823; pfam08853
1170562014747	FAD binding domain; Region: FAD_binding_4; pfam01565
1170562014748	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
1170562014749	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398
1170562014750	FIST N domain; Region: FIST; pfam08495
1170562014751	FIST C domain; Region: FIST_C; pfam10442
1170562014752	CP12 domain; Region: CP12; pfam02672
1170562014753	Protein of unknown function (DUF3177); Region: DUF3177; pfam11375
1170562014754	GMP synthase; Reviewed; Region: guaA; PRK00074
1170562014755	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
1170562014756	AMP/PPi binding site [chemical binding]; other site
1170562014757	candidate oxyanion hole; other site
1170562014758	catalytic triad [active]
1170562014759	potential glutamine specificity residues [chemical binding]; other site
1170562014760	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
1170562014761	ATP Binding subdomain [chemical binding]; other site
1170562014762	Ligand Binding sites [chemical binding]; other site
1170562014763	Dimerization subdomain; other site
1170562014764	Domain of unknown function (DUF1825); Region: DUF1825; pfam08855
1170562014765	Predicted membrane protein [Function unknown]; Region: XynA; COG2314
1170562014766	Short C-terminal domain; Region: SHOCT; pfam09851
1170562014767	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
1170562014768	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1170562014769	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1170562014770	Catalytic site [active]
1170562014771	Clp protease ATP binding subunit; Region: clpC; CHL00095
1170562014772	Clp amino terminal domain; Region: Clp_N; pfam02861
1170562014773	Clp amino terminal domain; Region: Clp_N; pfam02861
1170562014774	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1170562014775	Walker A motif; other site
1170562014776	ATP binding site [chemical binding]; other site
1170562014777	Walker B motif; other site
1170562014778	arginine finger; other site
1170562014779	UvrB/uvrC motif; Region: UVR; pfam02151
1170562014780	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1170562014781	Walker A motif; other site
1170562014782	ATP binding site [chemical binding]; other site
1170562014783	Walker B motif; other site
1170562014784	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1170562014785	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
1170562014786	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1170562014787	Coenzyme A binding pocket [chemical binding]; other site
1170562014788	diaminopimelate decarboxylase; Region: lysA; TIGR01048
1170562014789	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
1170562014790	active site
1170562014791	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1170562014792	substrate binding site [chemical binding]; other site
1170562014793	catalytic residues [active]
1170562014794	dimer interface [polypeptide binding]; other site
1170562014795	TIGR00159 family protein; Region: TIGR00159
1170562014796	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
1170562014797	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
1170562014798	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
1170562014799	catalytic residue [active]
1170562014800	putative FPP diphosphate  binding site; other site
1170562014801	putative FPP binding hydrophobic cleft; other site
1170562014802	dimer interface [polypeptide binding]; other site
1170562014803	putative IPP diphosphate binding site; other site
1170562014804	Protein of unknown function (DUF3143); Region: DUF3143; pfam11341
1170562014805	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1170562014806	HSP70 interaction site [polypeptide binding]; other site
1170562014807	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
1170562014808	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562014809	Mg2+ binding site [ion binding]; other site
1170562014810	G-X-G motif; other site
1170562014811	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1170562014812	anchoring element; other site
1170562014813	dimer interface [polypeptide binding]; other site
1170562014814	ATP binding site [chemical binding]; other site
1170562014815	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1170562014816	active site
1170562014817	putative metal-binding site [ion binding]; other site
1170562014818	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1170562014819	amino acid transporter; Region: 2A0306; TIGR00909
1170562014820	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
1170562014821	four helix bundle protein; Region: TIGR02436
1170562014822	Protein of unknown function (DUF1611); Region: DUF1611; pfam07755
1170562014823	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
1170562014824	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
1170562014825	active site
1170562014826	Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829
1170562014827	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
1170562014828	alpha-gamma subunit interface [polypeptide binding]; other site
1170562014829	beta-gamma subunit interface [polypeptide binding]; other site
1170562014830	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
1170562014831	gamma-beta subunit interface [polypeptide binding]; other site
1170562014832	alpha-beta subunit interface [polypeptide binding]; other site
1170562014833	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562014834	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1170562014835	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562014836	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562014837	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562014838	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1170562014839	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562014840	Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051
1170562014841	putative hexamer interface [polypeptide binding]; other site
1170562014842	putative hexagonal pore; other site
1170562014843	Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982
1170562014844	Hexamer interface [polypeptide binding]; other site
1170562014845	Hexagonal pore residue; other site
1170562014846	photosystem II reaction center protein H; Provisional; Region: psbH; PRK02624
1170562014847	TROVE domain; Region: TROVE; pfam05731
1170562014848	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
1170562014849	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1170562014850	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
1170562014851	dimerization interface [polypeptide binding]; other site
1170562014852	substrate binding pocket [chemical binding]; other site
1170562014853	Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182
1170562014854	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1170562014855	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1170562014856	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1170562014857	putative substrate translocation pore; other site
1170562014858	Uncharacterized conserved protein [Function unknown]; Region: COG5464
1170562014859	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
1170562014860	Caspase domain; Region: Peptidase_C14; pfam00656
1170562014861	GUN4-like; Region: GUN4; pfam05419
1170562014862	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
1170562014863	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
1170562014864	quinone interaction residues [chemical binding]; other site
1170562014865	active site
1170562014866	catalytic residues [active]
1170562014867	FMN binding site [chemical binding]; other site
1170562014868	substrate binding site [chemical binding]; other site
1170562014869	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1170562014870	GAF domain; Region: GAF; pfam01590
1170562014871	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1170562014872	GAF domain; Region: GAF; pfam01590
1170562014873	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1170562014874	GAF domain; Region: GAF; cl17456
1170562014875	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1170562014876	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1170562014877	glycogen branching enzyme; Provisional; Region: PRK05402
1170562014878	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
1170562014879	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
1170562014880	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
1170562014881	active site
1170562014882	catalytic site [active]
1170562014883	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
1170562014884	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1170562014885	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1170562014886	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1170562014887	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1170562014888	hydrophobic ligand binding site; other site
1170562014889	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
1170562014890	Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993
1170562014891	putative active site [active]
1170562014892	Zn binding site [ion binding]; other site
1170562014893	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
1170562014894	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562014895	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562014896	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1170562014897	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562014898	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
1170562014899	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1170562014900	Walker A/P-loop; other site
1170562014901	ATP binding site [chemical binding]; other site
1170562014902	Q-loop/lid; other site
1170562014903	ABC transporter signature motif; other site
1170562014904	Walker B; other site
1170562014905	D-loop; other site
1170562014906	H-loop/switch region; other site
1170562014907	TOBE domain; Region: TOBE_2; pfam08402
1170562014908	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
1170562014909	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
1170562014910	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1170562014911	active site
1170562014912	YcfA-like protein; Region: YcfA; pfam07927
1170562014913	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
1170562014914	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
1170562014915	active site
1170562014916	SAM binding site [chemical binding]; other site
1170562014917	homodimer interface [polypeptide binding]; other site
1170562014918	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
1170562014919	Precorrin-8X methylmutase; Region: CbiC; pfam02570
1170562014920	precorrin-3B synthase; Region: CobG; TIGR02435
1170562014921	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1170562014922	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1170562014923	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
1170562014924	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330
1170562014925	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
1170562014926	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
1170562014927	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
1170562014928	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
1170562014929	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1170562014930	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1170562014931	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1170562014932	ABC transporter; Region: ABC_tran_2; pfam12848
1170562014933	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1170562014934	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
1170562014935	Peptidase M14 Aspartoacylase (ASPA) subfamily; Region: M14_ASPA; cd06909
1170562014936	active site
1170562014937	Zn binding site [ion binding]; other site
1170562014938	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
1170562014939	oligomeric interface; other site
1170562014940	homodimer interface [polypeptide binding]; other site
1170562014941	putative active site [active]
1170562014942	peptide chain release factor 1; Validated; Region: prfA; PRK00591
1170562014943	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1170562014944	RF-1 domain; Region: RF-1; pfam00472
1170562014945	ribosomal protein L31; Validated; Region: rpl31; CHL00136
1170562014946	ribosomal protein S9; Region: rps9; CHL00079
1170562014947	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
1170562014948	23S rRNA interface [nucleotide binding]; other site
1170562014949	L3 interface [polypeptide binding]; other site
1170562014950	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
1170562014951	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
1170562014952	dimerization interface 3.5A [polypeptide binding]; other site
1170562014953	active site
1170562014954	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
1170562014955	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
1170562014956	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
1170562014957	alphaNTD - beta interaction site [polypeptide binding]; other site
1170562014958	alphaNTD homodimer interface [polypeptide binding]; other site
1170562014959	alphaNTD - beta' interaction site [polypeptide binding]; other site
1170562014960	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
1170562014961	30S ribosomal protein S11; Validated; Region: PRK05309
1170562014962	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
1170562014963	30S ribosomal protein S13; Region: bact_S13; TIGR03631
1170562014964	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
1170562014965	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
1170562014966	rRNA binding site [nucleotide binding]; other site
1170562014967	predicted 30S ribosome binding site; other site
1170562014968	adenylate kinase; Provisional; Region: adk; PRK02496
1170562014969	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
1170562014970	AMP-binding site [chemical binding]; other site
1170562014971	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
1170562014972	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
1170562014973	SecY translocase; Region: SecY; pfam00344
1170562014974	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
1170562014975	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
1170562014976	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
1170562014977	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
1170562014978	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
1170562014979	5S rRNA interface [nucleotide binding]; other site
1170562014980	23S rRNA interface [nucleotide binding]; other site
1170562014981	L5 interface [polypeptide binding]; other site
1170562014982	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
1170562014983	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1170562014984	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1170562014985	ribosomal protein S8; Region: rps8; CHL00042
1170562014986	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
1170562014987	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
1170562014988	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
1170562014989	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
1170562014990	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
1170562014991	RNA binding site [nucleotide binding]; other site
1170562014992	ribosomal protein L14; Region: rpl14; CHL00057
1170562014993	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
1170562014994	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
1170562014995	23S rRNA interface [nucleotide binding]; other site
1170562014996	putative translocon interaction site; other site
1170562014997	signal recognition particle (SRP54) interaction site; other site
1170562014998	L23 interface [polypeptide binding]; other site
1170562014999	trigger factor interaction site; other site
1170562015000	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
1170562015001	23S rRNA interface [nucleotide binding]; other site
1170562015002	5S rRNA interface [nucleotide binding]; other site
1170562015003	putative antibiotic binding site [chemical binding]; other site
1170562015004	L25 interface [polypeptide binding]; other site
1170562015005	L27 interface [polypeptide binding]; other site
1170562015006	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
1170562015007	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
1170562015008	G-X-X-G motif; other site
1170562015009	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
1170562015010	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
1170562015011	putative translocon binding site; other site
1170562015012	protein-rRNA interface [nucleotide binding]; other site
1170562015013	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
1170562015014	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
1170562015015	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
1170562015016	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
1170562015017	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
1170562015018	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
1170562015019	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
1170562015020	NADH-quinone oxidoreductase cyanobacterial subunit N; Region: NdhN; pfam11909
1170562015021	Protein of unknown function (DUF3442); Region: DUF3442; pfam11924
1170562015022	Protein of unknown function (DUF3172); Region: DUF3172; pfam11371
1170562015023	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1170562015024	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562015025	active site
1170562015026	phosphorylation site [posttranslational modification]
1170562015027	intermolecular recognition site; other site
1170562015028	dimerization interface [polypeptide binding]; other site
1170562015029	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1170562015030	DNA binding residues [nucleotide binding]
1170562015031	dimerization interface [polypeptide binding]; other site
1170562015032	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1170562015033	Histidine kinase; Region: HisKA_3; pfam07730
1170562015034	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562015035	ATP binding site [chemical binding]; other site
1170562015036	Mg2+ binding site [ion binding]; other site
1170562015037	G-X-G motif; other site
1170562015038	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
1170562015039	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
1170562015040	AMIN domain; Region: AMIN; pfam11741
1170562015041	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
1170562015042	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
1170562015043	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1170562015044	putative active site [active]
1170562015045	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562015046	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1170562015047	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562015048	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562015049	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1170562015050	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562015051	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562015052	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
1170562015053	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
1170562015054	cofactor binding site; other site
1170562015055	DNA binding site [nucleotide binding]
1170562015056	substrate interaction site [chemical binding]; other site
1170562015057	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
1170562015058	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
1170562015059	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
1170562015060	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
1170562015061	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
1170562015062	active site
1170562015063	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
1170562015064	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
1170562015065	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
1170562015066	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1170562015067	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
1170562015068	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1170562015069	Surface antigen; Region: Bac_surface_Ag; pfam01103
1170562015070	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
1170562015071	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
1170562015072	ATP binding site [chemical binding]; other site
1170562015073	active site
1170562015074	substrate binding site [chemical binding]; other site
1170562015075	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1170562015076	GAF domain; Region: GAF_2; pfam13185
1170562015077	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1170562015078	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1170562015079	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562015080	putative active site [active]
1170562015081	heme pocket [chemical binding]; other site
1170562015082	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1170562015083	cyclase homology domain; Region: CHD; cd07302
1170562015084	nucleotidyl binding site; other site
1170562015085	metal binding site [ion binding]; metal-binding site
1170562015086	dimer interface [polypeptide binding]; other site
1170562015087	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1170562015088	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
1170562015089	UDP_sulfoquinovose_synthase (Arabidopsis thaliana SQD1 and related proteins), extended (e) SDRs; Region: SQD1_like_SDR_e; cd05255
1170562015090	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1170562015091	NAD binding site [chemical binding]; other site
1170562015092	substrate binding site [chemical binding]; other site
1170562015093	active site
1170562015094	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
1170562015095	Active_site [active]
1170562015096	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1170562015097	phosphopeptide binding site; other site
1170562015098	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1170562015099	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1170562015100	phosphopeptide binding site; other site
1170562015101	GXWXG protein; Region: GXWXG; pfam14231
1170562015102	Domain of unknown function (DUF4334); Region: DUF4334; pfam14232
1170562015103	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_3; cd01835
1170562015104	active site
1170562015105	catalytic triad [active]
1170562015106	oxyanion hole [active]
1170562015107	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
1170562015108	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1170562015109	N-terminal plug; other site
1170562015110	ligand-binding site [chemical binding]; other site
1170562015111	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
1170562015112	methionine aminopeptidase; Provisional; Region: PRK12318
1170562015113	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1170562015114	active site
1170562015115	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1170562015116	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1170562015117	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1170562015118	DDE superfamily endonuclease; Region: DDE_5; cl17874
1170562015119	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1170562015120	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1170562015121	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1170562015122	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1170562015123	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1170562015124	active site
1170562015125	metal binding site [ion binding]; metal-binding site
1170562015126	Protein of unknown function (DUF2396); Region: DUF2396; pfam09654
1170562015127	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
1170562015128	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
1170562015129	trimer interface [polypeptide binding]; other site
1170562015130	putative metal binding site [ion binding]; other site
1170562015131	photosystem II protein Y; Reviewed; Region: pbsY; PRK13240
1170562015132	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
1170562015133	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1170562015134	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1170562015135	TRX domain, novel NADPH thioredoxin reductase (NTR) family; composed of fusion proteins found only in oxygenic photosynthetic organisms containing both TRX and NTR domains. The TRX domain functions as a protein disulfide reductase via the reversible...; Region: TRX_NTR; cd02949
1170562015136	catalytic residues [active]
1170562015137	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1170562015138	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562015139	dimer interface [polypeptide binding]; other site
1170562015140	phosphorylation site [posttranslational modification]
1170562015141	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562015142	ATP binding site [chemical binding]; other site
1170562015143	Mg2+ binding site [ion binding]; other site
1170562015144	G-X-G motif; other site
1170562015145	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
1170562015146	colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427
1170562015147	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
1170562015148	putative ADP-binding pocket [chemical binding]; other site
1170562015149	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1170562015150	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
1170562015151	active site
1170562015152	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
1170562015153	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
1170562015154	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
1170562015155	Walker A/P-loop; other site
1170562015156	ATP binding site [chemical binding]; other site
1170562015157	Q-loop/lid; other site
1170562015158	ABC transporter signature motif; other site
1170562015159	Walker B; other site
1170562015160	D-loop; other site
1170562015161	H-loop/switch region; other site
1170562015162	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
1170562015163	putative carbohydrate binding site [chemical binding]; other site
1170562015164	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1170562015165	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1170562015166	active site
1170562015167	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1170562015168	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1170562015169	active site
1170562015170	ATP binding site [chemical binding]; other site
1170562015171	substrate binding site [chemical binding]; other site
1170562015172	activation loop (A-loop); other site
1170562015173	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
1170562015174	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562015175	signal recognition particle protein; Provisional; Region: PRK10867
1170562015176	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
1170562015177	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1170562015178	GTP binding site [chemical binding]; other site
1170562015179	Signal peptide binding domain; Region: SRP_SPB; pfam02978
1170562015180	ribosomal protein S16; Region: rps16; CHL00005
1170562015181	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
1170562015182	KH domain; Region: KH_4; pfam13083
1170562015183	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
1170562015184	PhoH-like protein; Region: PhoH; pfam02562
1170562015185	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3322
1170562015186	HAMP domain; Region: HAMP; pfam00672
1170562015187	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
1170562015188	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
1170562015189	Protein of unknown function (DUF3352); Region: DUF3352; pfam11832
1170562015190	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
1170562015191	active site residue [active]
1170562015192	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
1170562015193	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1170562015194	HAMP domain; Region: HAMP; pfam00672
1170562015195	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562015196	dimer interface [polypeptide binding]; other site
1170562015197	phosphorylation site [posttranslational modification]
1170562015198	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562015199	ATP binding site [chemical binding]; other site
1170562015200	Mg2+ binding site [ion binding]; other site
1170562015201	G-X-G motif; other site
1170562015202	Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985
1170562015203	RibD C-terminal domain; Region: RibD_C; cl17279
1170562015204	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562015205	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1170562015206	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562015207	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
1170562015208	ATP-grasp domain; Region: ATP-grasp; pfam02222
1170562015209	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1170562015210	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1170562015211	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1170562015212	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1170562015213	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1170562015214	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1170562015215	Repair protein; Region: Repair_PSII; pfam04536
1170562015216	Domain of unknown function (DUF4346); Region: DUF4346; pfam14251
1170562015217	Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294
1170562015218	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3146
1170562015219	Protein of unknown function, DUF482; Region: DUF482; pfam04339
1170562015220	FOG: CBS domain [General function prediction only]; Region: COG0517
1170562015221	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_7; cd04620
1170562015222	FOG: CBS domain [General function prediction only]; Region: COG0517
1170562015223	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with a PAS domain, a GGDEF (DiGuanylate-Cyclase (DGC) domain, and a DUF1 domain downstream. PAS domains have been found to bind ligands, and to act...; Region: CBS_pair_PAS_GGDEF_DUF1_assoc; cd04611
1170562015224	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1170562015225	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1170562015226	PAS domain S-box; Region: sensory_box; TIGR00229
1170562015227	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562015228	putative active site [active]
1170562015229	heme pocket [chemical binding]; other site
1170562015230	PAS domain S-box; Region: sensory_box; TIGR00229
1170562015231	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562015232	putative active site [active]
1170562015233	heme pocket [chemical binding]; other site
1170562015234	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1170562015235	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1170562015236	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1170562015237	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562015238	dimer interface [polypeptide binding]; other site
1170562015239	phosphorylation site [posttranslational modification]
1170562015240	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562015241	ATP binding site [chemical binding]; other site
1170562015242	Mg2+ binding site [ion binding]; other site
1170562015243	G-X-G motif; other site
1170562015244	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1170562015245	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562015246	active site
1170562015247	phosphorylation site [posttranslational modification]
1170562015248	intermolecular recognition site; other site
1170562015249	dimerization interface [polypeptide binding]; other site
1170562015250	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562015251	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562015252	active site
1170562015253	phosphorylation site [posttranslational modification]
1170562015254	intermolecular recognition site; other site
1170562015255	dimerization interface [polypeptide binding]; other site
1170562015256	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562015257	PAS fold; Region: PAS_3; pfam08447
1170562015258	putative active site [active]
1170562015259	heme pocket [chemical binding]; other site
1170562015260	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1170562015261	GAF domain; Region: GAF; pfam01590
1170562015262	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562015263	PAS fold; Region: PAS_3; pfam08447
1170562015264	putative active site [active]
1170562015265	heme pocket [chemical binding]; other site
1170562015266	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1170562015267	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1170562015268	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562015269	dimer interface [polypeptide binding]; other site
1170562015270	phosphorylation site [posttranslational modification]
1170562015271	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562015272	ATP binding site [chemical binding]; other site
1170562015273	Mg2+ binding site [ion binding]; other site
1170562015274	G-X-G motif; other site
1170562015275	Coenzyme F420-reducing hydrogenase, beta subunit [Energy production and conversion]; Region: FrhB; COG1035
1170562015276	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422
1170562015277	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
1170562015278	gamma-glutamyl kinase; Provisional; Region: PRK05429
1170562015279	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
1170562015280	nucleotide binding site [chemical binding]; other site
1170562015281	homotetrameric interface [polypeptide binding]; other site
1170562015282	putative phosphate binding site [ion binding]; other site
1170562015283	putative allosteric binding site; other site
1170562015284	PUA domain; Region: PUA; pfam01472
1170562015285	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
1170562015286	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1170562015287	ATP binding site [chemical binding]; other site
1170562015288	putative Mg++ binding site [ion binding]; other site
1170562015289	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1170562015290	nucleotide binding region [chemical binding]; other site
1170562015291	ATP-binding site [chemical binding]; other site
1170562015292	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
1170562015293	HRDC domain; Region: HRDC; pfam00570
1170562015294	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
1170562015295	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1170562015296	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1170562015297	phosphopeptide binding site; other site
1170562015298	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1170562015299	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
1170562015300	FAD binding pocket [chemical binding]; other site
1170562015301	FAD binding motif [chemical binding]; other site
1170562015302	phosphate binding motif [ion binding]; other site
1170562015303	beta-alpha-beta structure motif; other site
1170562015304	NAD binding pocket [chemical binding]; other site
1170562015305	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1170562015306	catalytic loop [active]
1170562015307	iron binding site [ion binding]; other site
1170562015308	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1170562015309	PAS domain; Region: PAS_8; pfam13188
1170562015310	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1170562015311	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562015312	putative active site [active]
1170562015313	heme pocket [chemical binding]; other site
1170562015314	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562015315	PAS fold; Region: PAS_3; pfam08447
1170562015316	putative active site [active]
1170562015317	heme pocket [chemical binding]; other site
1170562015318	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1170562015319	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562015320	dimer interface [polypeptide binding]; other site
1170562015321	phosphorylation site [posttranslational modification]
1170562015322	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562015323	ATP binding site [chemical binding]; other site
1170562015324	Mg2+ binding site [ion binding]; other site
1170562015325	G-X-G motif; other site
1170562015326	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343
1170562015327	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
1170562015328	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1170562015329	putative binding surface; other site
1170562015330	active site
1170562015331	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
1170562015332	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
1170562015333	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562015334	ATP binding site [chemical binding]; other site
1170562015335	Mg2+ binding site [ion binding]; other site
1170562015336	G-X-G motif; other site
1170562015337	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
1170562015338	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1170562015339	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562015340	active site
1170562015341	phosphorylation site [posttranslational modification]
1170562015342	intermolecular recognition site; other site
1170562015343	dimerization interface [polypeptide binding]; other site
1170562015344	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1170562015345	dimerization interface [polypeptide binding]; other site
1170562015346	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1170562015347	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1170562015348	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1170562015349	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1170562015350	dimer interface [polypeptide binding]; other site
1170562015351	putative CheW interface [polypeptide binding]; other site
1170562015352	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
1170562015353	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562015354	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562015355	active site
1170562015356	phosphorylation site [posttranslational modification]
1170562015357	intermolecular recognition site; other site
1170562015358	dimerization interface [polypeptide binding]; other site
1170562015359	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
1170562015360	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562015361	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562015362	active site
1170562015363	phosphorylation site [posttranslational modification]
1170562015364	intermolecular recognition site; other site
1170562015365	dimerization interface [polypeptide binding]; other site
1170562015366	alanine racemase; Reviewed; Region: alr; PRK00053
1170562015367	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
1170562015368	active site
1170562015369	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1170562015370	dimer interface [polypeptide binding]; other site
1170562015371	substrate binding site [chemical binding]; other site
1170562015372	catalytic residues [active]
1170562015373	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
1170562015374	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1170562015375	active site
1170562015376	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
1170562015377	DHH family; Region: DHH; pfam01368
1170562015378	Protein of unknown function (DUF2862); Region: DUF2862; pfam11061
1170562015379	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
1170562015380	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
1170562015381	P loop; other site
1170562015382	Nucleotide binding site [chemical binding]; other site
1170562015383	Switch I; other site
1170562015384	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
1170562015385	UbiA prenyltransferase family; Region: UbiA; pfam01040
1170562015386	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
1170562015387	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
1170562015388	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1170562015389	S-adenosylmethionine binding site [chemical binding]; other site
1170562015390	Protease prsW family; Region: PrsW-protease; cl15823
1170562015391	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
1170562015392	active site
1170562015393	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
1170562015394	active site
1170562015395	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1170562015396	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1170562015397	P-loop; other site
1170562015398	Magnesium ion binding site [ion binding]; other site
1170562015399	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1170562015400	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
1170562015401	homodimer interface [polypeptide binding]; other site
1170562015402	substrate-cofactor binding pocket; other site
1170562015403	catalytic residue [active]
1170562015404	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1170562015405	DNA polymerase II large subunit; Provisional; Region: PRK14714
1170562015406	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14457
1170562015407	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1170562015408	FeS/SAM binding site; other site
1170562015409	macrophage migration inhibition factor-like protein; Provisional; Region: PTZ00397
1170562015410	Gtr1/RagA G protein conserved region; Region: Gtr1_RagA; pfam04670
1170562015411	Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550
1170562015412	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1170562015413	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1170562015414	ring oligomerisation interface [polypeptide binding]; other site
1170562015415	ATP/Mg binding site [chemical binding]; other site
1170562015416	stacking interactions; other site
1170562015417	hinge regions; other site
1170562015418	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
1170562015419	oligomerisation interface [polypeptide binding]; other site
1170562015420	mobile loop; other site
1170562015421	roof hairpin; other site
1170562015422	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1170562015423	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562015424	active site
1170562015425	phosphorylation site [posttranslational modification]
1170562015426	intermolecular recognition site; other site
1170562015427	dimerization interface [polypeptide binding]; other site
1170562015428	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1170562015429	DNA binding residues [nucleotide binding]
1170562015430	dimerization interface [polypeptide binding]; other site
1170562015431	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
1170562015432	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
1170562015433	Mg++ binding site [ion binding]; other site
1170562015434	putative catalytic motif [active]
1170562015435	putative substrate binding site [chemical binding]; other site
1170562015436	Protein of unknown function (DUF3134); Region: DUF3134; pfam11332
1170562015437	PAP_fibrillin; Region: PAP_fibrillin; pfam04755
1170562015438	photosystem I reaction center subunit IV; Provisional; Region: PRK02749
1170562015439	formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK13945
1170562015440	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
1170562015441	DNA binding site [nucleotide binding]
1170562015442	catalytic residue [active]
1170562015443	H2TH interface [polypeptide binding]; other site
1170562015444	putative catalytic residues [active]
1170562015445	turnover-facilitating residue; other site
1170562015446	intercalation triad [nucleotide binding]; other site
1170562015447	8OG recognition residue [nucleotide binding]; other site
1170562015448	putative reading head residues; other site
1170562015449	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1170562015450	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1170562015451	Cyanobacterial and plant NDH-1 subunit O; Region: NdhO; pfam11910
1170562015452	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
1170562015453	PemK-like protein; Region: PemK; pfam02452
1170562015454	Domain of unknown function (DUF1802); Region: DUF1802; cl01755
1170562015455	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096
1170562015456	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
1170562015457	active site
1170562015458	dimer interface [polypeptide binding]; other site
1170562015459	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
1170562015460	dimer interface [polypeptide binding]; other site
1170562015461	active site
1170562015462	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1170562015463	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
1170562015464	dimerization interface [polypeptide binding]; other site
1170562015465	ligand binding site [chemical binding]; other site
1170562015466	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1170562015467	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1170562015468	TM-ABC transporter signature motif; other site
1170562015469	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1170562015470	TM-ABC transporter signature motif; other site
1170562015471	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1170562015472	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1170562015473	Walker A/P-loop; other site
1170562015474	ATP binding site [chemical binding]; other site
1170562015475	Q-loop/lid; other site
1170562015476	ABC transporter signature motif; other site
1170562015477	Walker B; other site
1170562015478	D-loop; other site
1170562015479	H-loop/switch region; other site
1170562015480	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1170562015481	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1170562015482	Walker A/P-loop; other site
1170562015483	ATP binding site [chemical binding]; other site
1170562015484	Q-loop/lid; other site
1170562015485	ABC transporter signature motif; other site
1170562015486	Walker B; other site
1170562015487	D-loop; other site
1170562015488	H-loop/switch region; other site
1170562015489	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136
1170562015490	putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279
1170562015491	Protein of unknown function (DUF512); Region: DUF512; pfam04459
1170562015492	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1170562015493	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
1170562015494	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1170562015495	FOG: CBS domain [General function prediction only]; Region: COG0517
1170562015496	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1170562015497	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562015498	putative active site [active]
1170562015499	heme pocket [chemical binding]; other site
1170562015500	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1170562015501	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562015502	putative active site [active]
1170562015503	heme pocket [chemical binding]; other site
1170562015504	PAS domain; Region: PAS; smart00091
1170562015505	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562015506	PAS domain; Region: PAS_9; pfam13426
1170562015507	putative active site [active]
1170562015508	heme pocket [chemical binding]; other site
1170562015509	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1170562015510	PAS fold; Region: PAS_3; pfam08447
1170562015511	putative active site [active]
1170562015512	heme pocket [chemical binding]; other site
1170562015513	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
1170562015514	dimer interface [polypeptide binding]; other site
1170562015515	phosphorylation site [posttranslational modification]
1170562015516	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
1170562015517	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562015518	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562015519	active site
1170562015520	phosphorylation site [posttranslational modification]
1170562015521	intermolecular recognition site; other site
1170562015522	dimerization interface [polypeptide binding]; other site
1170562015523	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1170562015524	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
1170562015525	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1170562015526	non-specific DNA binding site [nucleotide binding]; other site
1170562015527	salt bridge; other site
1170562015528	sequence-specific DNA binding site [nucleotide binding]; other site
1170562015529	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1170562015530	HEAT repeats; Region: HEAT_2; pfam13646
1170562015531	HEAT repeats; Region: HEAT_2; pfam13646
1170562015532	HEAT repeats; Region: HEAT_2; pfam13646
1170562015533	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1170562015534	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1170562015535	Coenzyme A binding pocket [chemical binding]; other site
1170562015536	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
1170562015537	hypothetical protein; Validated; Region: PRK07413
1170562015538	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
1170562015539	Walker A motif; other site
1170562015540	homodimer interface [polypeptide binding]; other site
1170562015541	ATP binding site [chemical binding]; other site
1170562015542	hydroxycobalamin binding site [chemical binding]; other site
1170562015543	Walker B motif; other site
1170562015544	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
1170562015545	homodimer interface [polypeptide binding]; other site
1170562015546	Walker A motif; other site
1170562015547	ATP binding site [chemical binding]; other site
1170562015548	hydroxycobalamin binding site [chemical binding]; other site
1170562015549	Walker B motif; other site
1170562015550	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
1170562015551	GAF domain; Region: GAF; pfam01590
1170562015552	Phytochrome region; Region: PHY; pfam00360
1170562015553	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1170562015554	dimer interface [polypeptide binding]; other site
1170562015555	phosphorylation site [posttranslational modification]
1170562015556	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562015557	ATP binding site [chemical binding]; other site
1170562015558	Mg2+ binding site [ion binding]; other site
1170562015559	G-X-G motif; other site
1170562015560	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562015561	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562015562	active site
1170562015563	phosphorylation site [posttranslational modification]
1170562015564	intermolecular recognition site; other site
1170562015565	dimerization interface [polypeptide binding]; other site
1170562015566	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1170562015567	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
1170562015568	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
1170562015569	putative dimerization interface [polypeptide binding]; other site
1170562015570	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
1170562015571	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1170562015572	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1170562015573	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1170562015574	Walker A/P-loop; other site
1170562015575	ATP binding site [chemical binding]; other site
1170562015576	Q-loop/lid; other site
1170562015577	ABC transporter signature motif; other site
1170562015578	Walker B; other site
1170562015579	D-loop; other site
1170562015580	H-loop/switch region; other site
1170562015581	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1170562015582	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1170562015583	active site
1170562015584	ATP binding site [chemical binding]; other site
1170562015585	substrate binding site [chemical binding]; other site
1170562015586	activation loop (A-loop); other site
1170562015587	PsbP; Region: PsbP; cl03356
1170562015588	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1170562015589	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562015590	TPR motif; other site
1170562015591	binding surface
1170562015592	TPR repeat; Region: TPR_11; pfam13414
1170562015593	TPR repeat; Region: TPR_11; pfam13414
1170562015594	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1170562015595	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562015596	TPR repeat; Region: TPR_11; pfam13414
1170562015597	TPR motif; other site
1170562015598	binding surface
1170562015599	TPR repeat; Region: TPR_11; pfam13414
1170562015600	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1170562015601	binding surface
1170562015602	TPR motif; other site
1170562015603	TPR repeat; Region: TPR_11; pfam13414
1170562015604	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1170562015605	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
1170562015606	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
1170562015607	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
1170562015608	trimer interface [polypeptide binding]; other site
1170562015609	active site
1170562015610	UDP-GlcNAc binding site [chemical binding]; other site
1170562015611	lipid binding site [chemical binding]; lipid-binding site
1170562015612	DNA polymerase III subunit delta; Validated; Region: PRK07452
1170562015613	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
1170562015614	Domain of unknown function (DUF4168); Region: DUF4168; pfam13767
1170562015615	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1170562015616	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1170562015617	Predicted membrane protein [Function unknown]; Region: COG1808
1170562015618	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
1170562015619	Protein of unknown function (DUF2805); Region: DUF2805; pfam10985
1170562015620	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1170562015621	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1170562015622	DNA binding residues [nucleotide binding]
1170562015623	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
1170562015624	MgtE intracellular N domain; Region: MgtE_N; smart00924
1170562015625	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
1170562015626	Divalent cation transporter; Region: MgtE; pfam01769
1170562015627	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1170562015628	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1170562015629	motif II; other site
1170562015630	Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
1170562015631	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
1170562015632	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
1170562015633	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1170562015634	ATP binding site [chemical binding]; other site
1170562015635	Mg2+ binding site [ion binding]; other site
1170562015636	G-X-G motif; other site
1170562015637	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562015638	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562015639	active site
1170562015640	phosphorylation site [posttranslational modification]
1170562015641	intermolecular recognition site; other site
1170562015642	dimerization interface [polypeptide binding]; other site
1170562015643	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1170562015644	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1170562015645	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
1170562015646	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
1170562015647	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1170562015648	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562015649	active site
1170562015650	phosphorylation site [posttranslational modification]
1170562015651	intermolecular recognition site; other site
1170562015652	dimerization interface [polypeptide binding]; other site
1170562015653	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1170562015654	DNA binding residues [nucleotide binding]
1170562015655	dimerization interface [polypeptide binding]; other site
1170562015656	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
1170562015657	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
1170562015658	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
1170562015659	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1170562015660	active site
1170562015661	ATP binding site [chemical binding]; other site
1170562015662	substrate binding site [chemical binding]; other site
1170562015663	activation loop (A-loop); other site
1170562015664	Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385
1170562015665	Stage II sporulation protein; Region: SpoIID; pfam08486
1170562015666	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1170562015667	active site
1170562015668	Transposase IS200 like; Region: Y1_Tnp; cl00848
1170562015669	magnesium chelatase subunit H; Provisional; Region: PRK12493
1170562015670	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
1170562015671	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
1170562015672	Uncharacterized conserved protein [Function unknown]; Region: COG5464
1170562015673	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1170562015674	phosphopeptide binding site; other site
1170562015675	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1170562015676	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1170562015677	phosphopeptide binding site; other site
1170562015678	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1170562015679	Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213
1170562015680	Walker A/P-loop; other site
1170562015681	ATP binding site [chemical binding]; other site
1170562015682	Q-loop/lid; other site
1170562015683	ABC transporter signature motif; other site
1170562015684	Walker B; other site
1170562015685	D-loop; other site
1170562015686	H-loop/switch region; other site
1170562015687	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1170562015688	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
1170562015689	2-isopropylmalate synthase; Validated; Region: PRK03739
1170562015690	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
1170562015691	active site
1170562015692	catalytic residues [active]
1170562015693	metal binding site [ion binding]; metal-binding site
1170562015694	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
1170562015695	Response regulator receiver domain; Region: Response_reg; pfam00072
1170562015696	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1170562015697	active site
1170562015698	phosphorylation site [posttranslational modification]
1170562015699	intermolecular recognition site; other site
1170562015700	dimerization interface [polypeptide binding]; other site
1170562015701	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1170562015702	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1170562015703	metal binding site [ion binding]; metal-binding site
1170562015704	active site
1170562015705	I-site; other site
1170562015706	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1170562015707	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1170562015708	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
1170562015709	Iron-Sulfur binding protein C terminal; Region: LdpA_C; pfam12617
1170562015710	ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854
1170562015711	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1170562015712	Walker A motif; other site
1170562015713	ATP binding site [chemical binding]; other site
1170562015714	Walker B motif; other site
1170562015715	R3H domain of a group of proteins with unknown function, who also contain a AAA-ATPase (AAA) domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is...; Region: R3H_AAA; cd02645
1170562015716	RxxxH motif; other site
1170562015717	complex I subunit; Region: PLN02755
1170562015718	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
1170562015719	RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646
1170562015720	putative active site [active]
1170562015721	putative NTP binding site [chemical binding]; other site
1170562015722	putative nucleic acid binding site [nucleotide binding]; other site
1170562015723	Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581
1170562015724	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1170562015725	ATP binding site [chemical binding]; other site
1170562015726	putative Mg++ binding site [ion binding]; other site
1170562015727	helicase superfamily c-terminal domain; Region: HELICc; smart00490
1170562015728	nucleotide binding region [chemical binding]; other site
1170562015729	ATP-binding site [chemical binding]; other site
1170562015730	Protein of unknown function (DUF972); Region: DUF972; pfam06156
1170562015731	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
1170562015732	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
1170562015733	pyrroline-5-carboxylate reductase; Region: PLN02688
1170562015734	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
1170562015735	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
1170562015736	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1170562015737	catalytic residue [active]
1170562015738	Protein of unknown function (DUF3539); Region: DUF3539; pfam12058
1170562015739	Uncharacterized conserved protein [Function unknown]; Region: COG3339
1170562015740	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
1170562015741	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1170562015742	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
1170562015743	Predicted membrane protein [Function unknown]; Region: COG1950
1170562015744	Thf1-like protein; Reviewed; Region: PRK13266
1170562015745	photosystem II biogenesis protein Psp29; Region: PS_II_psb29; TIGR03060
1170562015746	CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206
1170562015747	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1170562015748	anti sigma factor interaction site; other site
1170562015749	regulatory phosphorylation site [posttranslational modification]; other site
1170562015750	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
1170562015751	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
1170562015752	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1170562015753	hydrophobic ligand binding site; other site
1170562015754	Domain of unknown function DUF59; Region: DUF59; pfam01883
1170562015755	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
1170562015756	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
1170562015757	Walker A motif; other site
1170562015758	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
1170562015759	Protein of unknown function (DUF3252); Region: DUF3252; pfam11623
1170562015760	HAS barrel domain; Region: HAS-barrel; pfam09378
1170562015761	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1170562015762	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1170562015763	The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988
1170562015764	Ligand Binding Site [chemical binding]; other site
1170562015765	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1170562015766	Ligand Binding Site [chemical binding]; other site
1170562015767	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1170562015768	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
1170562015769	NAD binding site [chemical binding]; other site
1170562015770	putative substrate binding site 2 [chemical binding]; other site
1170562015771	putative substrate binding site 1 [chemical binding]; other site
1170562015772	active site
1170562015773	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
1170562015774	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1170562015775	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
1170562015776	allophycocyanin, beta subunit; Region: apcB; TIGR01337
1170562015777	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
1170562015778	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1170562015779	RNA binding surface [nucleotide binding]; other site
1170562015780	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
1170562015781	DNA polymerase I; Provisional; Region: PRK05755
1170562015782	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1170562015783	active site
1170562015784	metal binding site 1 [ion binding]; metal-binding site
1170562015785	putative 5' ssDNA interaction site; other site
1170562015786	metal binding site 3; metal-binding site
1170562015787	metal binding site 2 [ion binding]; metal-binding site
1170562015788	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1170562015789	putative DNA binding site [nucleotide binding]; other site
1170562015790	putative metal binding site [ion binding]; other site
1170562015791	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
1170562015792	active site
1170562015793	catalytic site [active]
1170562015794	substrate binding site [chemical binding]; other site
1170562015795	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
1170562015796	active site
1170562015797	DNA binding site [nucleotide binding]
1170562015798	catalytic site [active]
1170562015799	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1170562015800	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
1170562015801	phytoene desaturase; Region: phytoene_desat; TIGR02731
1170562015802	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1170562015803	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
1170562015804	active site lid residues [active]
1170562015805	substrate binding pocket [chemical binding]; other site
1170562015806	catalytic residues [active]
1170562015807	substrate-Mg2+ binding site; other site
1170562015808	aspartate-rich region 1; other site
1170562015809	aspartate-rich region 2; other site
1170562015810	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
1170562015811	putative acyl-acceptor binding pocket; other site
1170562015812	Domain of unknown function (DUF309); Region: DUF309; pfam03745
1170562015813	ferredoxin thioreductase subunit beta; Validated; Region: ftrB; CHL00165
1170562015814	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
1170562015815	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1170562015816	Walker A motif; other site
1170562015817	ATP binding site [chemical binding]; other site
1170562015818	Walker B motif; other site
1170562015819	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
1170562015820	Protein of unknown function DUF58; Region: DUF58; pfam01882
1170562015821	Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988
1170562015822	ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465
1170562015823	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
1170562015824	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1170562015825	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1170562015826	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1170562015827	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1170562015828	Walker A/P-loop; other site
1170562015829	ATP binding site [chemical binding]; other site
1170562015830	Q-loop/lid; other site
1170562015831	ABC transporter signature motif; other site
1170562015832	Walker B; other site
1170562015833	D-loop; other site
1170562015834	H-loop/switch region; other site
1170562015835	TOBE domain; Region: TOBE_2; pfam08402
1170562015836	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
1170562015837	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1170562015838	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1170562015839	dimer interface [polypeptide binding]; other site
1170562015840	conserved gate region; other site
1170562015841	putative PBP binding loops; other site
1170562015842	ABC-ATPase subunit interface; other site
1170562015843	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1170562015844	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1170562015845	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1170562015846	Phosphotransferase enzyme family; Region: APH; pfam01636
1170562015847	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1170562015848	active site
1170562015849	ATP binding site [chemical binding]; other site
1170562015850	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1170562015851	substrate binding site [chemical binding]; other site
1170562015852	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1170562015853	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1170562015854	protein binding site [polypeptide binding]; other site
1170562015855	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1170562015856	non-specific DNA binding site [nucleotide binding]; other site
1170562015857	salt bridge; other site
1170562015858	sequence-specific DNA binding site [nucleotide binding]; other site
1170562015859	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
1170562015860	PIN domain; Region: PIN; pfam01850
1170562015861	putative active site [active]
1170562015862	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1170562015863	active site
1170562015864	DNA binding site [nucleotide binding]
1170562015865	Int/Topo IB signature motif; other site
1170562015866	Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782
1170562015867	Predicted aspartyl protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5550; cl17622
1170562015868	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1170562015869	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
1170562015870	active site
1170562015871	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1170562015872	non-specific DNA binding site [nucleotide binding]; other site
1170562015873	salt bridge; other site
1170562015874	sequence-specific DNA binding site [nucleotide binding]; other site
1170562015875	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1170562015876	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1170562015877	ATP binding site [chemical binding]; other site
1170562015878	putative Mg++ binding site [ion binding]; other site
1170562015879	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1170562015880	nucleotide binding site [chemical binding]; other site
1170562015881	hypothetical protein; Region: PHA01623
1170562015882	GIY-YIG type nucleases (URI domain); Region: GIYc; smart00465
1170562015883	GIY-YIG motif/motif A; other site
1170562015884	active site
1170562015885	catalytic site [active]
1170562015886	metal binding site [ion binding]; metal-binding site
1170562015887	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1170562015888	non-specific DNA binding site [nucleotide binding]; other site
1170562015889	salt bridge; other site
1170562015890	sequence-specific DNA binding site [nucleotide binding]; other site
1170562015891	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
1170562015892	active site
1170562015893	metal binding site [ion binding]; metal-binding site
1170562015894	interdomain interaction site; other site
1170562015895	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709
1170562015896	Peptidase family M50; Region: Peptidase_M50; pfam02163
1170562015897	active site
1170562015898	putative substrate binding region [chemical binding]; other site
1170562015899	Leishmanolysin; Region: Peptidase_M8; pfam01457
1170562015900	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1170562015901	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1170562015902	P-loop; other site
1170562015903	Magnesium ion binding site [ion binding]; other site
1170562015904	ParB-like nuclease domain; Region: ParB; smart00470
1170562015905	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
1170562015906	AAA domain; Region: AAA_12; pfam13087
1170562015907	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
1170562015908	oligomeric interface; other site
1170562015909	putative active site [active]
1170562015910	homodimer interface [polypeptide binding]; other site
1170562015911	Protein of unknown function (DUF2281); Region: DUF2281; cl02355
1170562015912	herpesvirus tegument protein/v-FGAM-synthase; Region: tegu_FGAM_synt; TIGR01739
1170562015913	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1170562015914	Walker A motif; other site
1170562015915	ATP binding site [chemical binding]; other site
1170562015916	HEAT repeats; Region: HEAT_2; pfam13646
1170562015917	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
1170562015918	HEAT repeats; Region: HEAT_2; pfam13646
1170562015919	HEAT repeat; Region: HEAT; pfam02985
1170562015920	Plasmid recombination enzyme; Region: Mob_Pre; pfam01076
1170562015921	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
1170562015922	Toprim-like; Region: Toprim_2; pfam13155
1170562015923	Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205
1170562015924	DEAD/DEAH box helicase; Region: DEAD; pfam00270