-- dump date 20140619_020820 -- class Genbank::misc_feature -- table misc_feature_note -- id note 768670000001 Dynamin family; Region: Dynamin_N; pfam00350 768670000002 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 768670000003 G3 box; other site 768670000004 Switch II region; other site 768670000005 G4 box; other site 768670000006 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 768670000007 Dynamin family; Region: Dynamin_N; pfam00350 768670000008 G1 box; other site 768670000009 GTP/Mg2+ binding site [chemical binding]; other site 768670000010 G2 box; other site 768670000011 Switch I region; other site 768670000012 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 768670000013 G3 box; other site 768670000014 Switch II region; other site 768670000015 G4 box; other site 768670000016 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 768670000017 Dynamin family; Region: Dynamin_N; pfam00350 768670000018 G1 box; other site 768670000019 GTP/Mg2+ binding site [chemical binding]; other site 768670000020 G2 box; other site 768670000021 Switch I region; other site 768670000022 G3 box; other site 768670000023 Switch II region; other site 768670000024 G4 box; other site 768670000025 Transposase IS200 like; Region: Y1_Tnp; pfam01797 768670000026 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 768670000027 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 768670000028 Probable transposase; Region: OrfB_IS605; pfam01385 768670000029 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 768670000030 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 768670000031 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 768670000032 Right handed beta helix region; Region: Beta_helix; pfam13229 768670000033 Right handed beta helix region; Region: Beta_helix; pfam13229 768670000034 Right handed beta helix region; Region: Beta_helix; pfam13229 768670000035 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768670000036 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 768670000037 Walker A motif; other site 768670000038 ATP binding site [chemical binding]; other site 768670000039 Walker B motif; other site 768670000040 arginine finger; other site 768670000041 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 768670000042 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 768670000043 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 768670000044 active site 768670000045 DNA binding site [nucleotide binding] 768670000046 Int/Topo IB signature motif; other site 768670000047 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 768670000048 AAA domain; Region: AAA_14; pfam13173 768670000049 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 768670000050 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768670000051 TPR motif; other site 768670000052 binding surface 768670000053 Sel1-like repeats; Region: SEL1; smart00671 768670000054 Sel1-like repeats; Region: SEL1; smart00671 768670000055 ParB-like nuclease domain; Region: ParB; smart00470 768670000056 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 768670000057 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 768670000058 P-loop; other site 768670000059 Magnesium ion binding site [ion binding]; other site 768670000060 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 768670000061 Magnesium ion binding site [ion binding]; other site 768670000062 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 768670000063 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768670000064 Walker A motif; other site 768670000065 ATP binding site [chemical binding]; other site 768670000066 Walker B motif; other site 768670000067 Transposase IS200 like; Region: Y1_Tnp; pfam01797 768670000068 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 768670000069 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 768670000070 Probable transposase; Region: OrfB_IS605; pfam01385 768670000071 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 768670000072 Transposase, Mutator family; Region: Transposase_mut; pfam00872 768670000073 MULE transposase domain; Region: MULE; pfam10551 768670000074 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 768670000075 DNA methylase; Region: N6_N4_Mtase; pfam01555 768670000076 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 768670000077 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 768670000078 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 768670000079 active site 768670000080 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 768670000081 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 768670000082 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 768670000083 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 768670000084 ABC-2 type transporter; Region: ABC2_membrane; cl17235 768670000085 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 768670000086 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 768670000087 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768670000088 Walker A/P-loop; other site 768670000089 ATP binding site [chemical binding]; other site 768670000090 Q-loop/lid; other site 768670000091 ABC transporter signature motif; other site 768670000092 Walker B; other site 768670000093 D-loop; other site 768670000094 H-loop/switch region; other site 768670000095 Cobyrinic acid a,c-diamide synthase [Coenzyme metabolism]; Region: CobB; COG1797 768670000096 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 768670000097 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 768670000098 catalytic triad [active] 768670000099 Cobalt chelatase (CbiK); Region: CbiK; pfam06180 768670000100 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 768670000101 active site 768670000102 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 768670000103 active site 768670000104 N-terminal domain interface [polypeptide binding]; other site 768670000105 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 768670000106 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768670000107 dimer interface [polypeptide binding]; other site 768670000108 putative PBP binding regions; other site 768670000109 ABC-ATPase subunit interface; other site 768670000110 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 768670000111 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 768670000112 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 768670000113 Walker A/P-loop; other site 768670000114 ATP binding site [chemical binding]; other site 768670000115 Q-loop/lid; other site 768670000116 ABC transporter signature motif; other site 768670000117 Walker B; other site 768670000118 D-loop; other site 768670000119 H-loop/switch region; other site 768670000120 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 768670000121 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 768670000122 intersubunit interface [polypeptide binding]; other site 768670000123 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 768670000124 active site 768670000125 SAM binding site [chemical binding]; other site 768670000126 homodimer interface [polypeptide binding]; other site 768670000127 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 768670000128 active site 768670000129 SAM binding site [chemical binding]; other site 768670000130 homodimer interface [polypeptide binding]; other site 768670000131 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 768670000132 Precorrin-8X methylmutase; Region: CbiC; pfam02570 768670000133 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 768670000134 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 768670000135 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768670000136 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768670000137 homodimer interface [polypeptide binding]; other site 768670000138 catalytic residue [active] 768670000139 cobyric acid synthase; Provisional; Region: PRK00784 768670000140 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 768670000141 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 768670000142 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 768670000143 catalytic triad [active] 768670000144 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 768670000145 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 768670000146 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 768670000147 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 768670000148 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 768670000149 active site 768670000150 putative homodimer interface [polypeptide binding]; other site 768670000151 SAM binding site [chemical binding]; other site 768670000152 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 768670000153 active site 768670000154 SAM binding site [chemical binding]; other site 768670000155 homodimer interface [polypeptide binding]; other site 768670000156 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 768670000157 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 768670000158 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 768670000159 active site 768670000160 SAM binding site [chemical binding]; other site 768670000161 homodimer interface [polypeptide binding]; other site 768670000162 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 768670000163 tetramer interface [polypeptide binding]; other site 768670000164 threonine dehydratase; Provisional; Region: PRK08198 768670000165 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768670000166 catalytic residue [active] 768670000167 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 768670000168 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 768670000169 DnaA N-terminal domain; Region: DnaA_N; pfam11638 768670000170 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768670000171 Walker A motif; other site 768670000172 ATP binding site [chemical binding]; other site 768670000173 Walker B motif; other site 768670000174 arginine finger; other site 768670000175 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 768670000176 DnaA box-binding interface [nucleotide binding]; other site 768670000177 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 768670000178 DNA polymerase III subunit beta; Validated; Region: PRK05643 768670000179 putative DNA binding surface [nucleotide binding]; other site 768670000180 dimer interface [polypeptide binding]; other site 768670000181 beta-clamp/clamp loader binding surface; other site 768670000182 beta-clamp/translesion DNA polymerase binding surface; other site 768670000183 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 768670000184 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768670000185 Walker A/P-loop; other site 768670000186 ATP binding site [chemical binding]; other site 768670000187 Q-loop/lid; other site 768670000188 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768670000189 ABC transporter signature motif; other site 768670000190 Walker B; other site 768670000191 D-loop; other site 768670000192 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 768670000193 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768670000194 Mg2+ binding site [ion binding]; other site 768670000195 G-X-G motif; other site 768670000196 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 768670000197 anchoring element; other site 768670000198 dimer interface [polypeptide binding]; other site 768670000199 ATP binding site [chemical binding]; other site 768670000200 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 768670000201 active site 768670000202 putative metal-binding site [ion binding]; other site 768670000203 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 768670000204 DNA gyrase subunit A; Validated; Region: PRK05560 768670000205 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 768670000206 CAP-like domain; other site 768670000207 active site 768670000208 primary dimer interface [polypeptide binding]; other site 768670000209 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 768670000210 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 768670000211 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 768670000212 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 768670000213 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 768670000214 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 768670000215 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 768670000216 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 768670000217 homodimer interface [polypeptide binding]; other site 768670000218 NADP binding site [chemical binding]; other site 768670000219 substrate binding site [chemical binding]; other site 768670000220 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 768670000221 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 768670000222 trmE is a tRNA modification GTPase; Region: trmE; cd04164 768670000223 G1 box; other site 768670000224 GTP/Mg2+ binding site [chemical binding]; other site 768670000225 Switch I region; other site 768670000226 G2 box; other site 768670000227 Switch II region; other site 768670000228 G3 box; other site 768670000229 G4 box; other site 768670000230 G5 box; other site 768670000231 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 768670000232 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 768670000233 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 768670000234 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 768670000235 Protein of unknown function (DUF3016); Region: DUF3016; pfam11454 768670000236 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 768670000237 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 768670000238 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 768670000239 Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041 768670000240 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 768670000241 dinuclear metal binding motif [ion binding]; other site 768670000242 AAA ATPase domain; Region: AAA_16; pfam13191 768670000243 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 768670000244 Walker A motif; other site 768670000245 ATP binding site [chemical binding]; other site 768670000246 Walker B motif; other site 768670000247 Bacterial SH3 domain; Region: SH3_3; pfam08239 768670000248 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 768670000249 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 768670000250 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 768670000251 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768670000252 DNA binding residues [nucleotide binding] 768670000253 N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859 768670000254 glycogen binding site [chemical binding]; other site 768670000255 Domain of unknown function (DUF1858); Region: DUF1858; pfam08984 768670000256 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 768670000257 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 768670000258 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 768670000259 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768670000260 Walker A/P-loop; other site 768670000261 ATP binding site [chemical binding]; other site 768670000262 Q-loop/lid; other site 768670000263 ABC transporter signature motif; other site 768670000264 Walker B; other site 768670000265 D-loop; other site 768670000266 H-loop/switch region; other site 768670000267 Nitrous oxide-stimulated promoter; Region: YgbA_NO; cl08119 768670000268 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 768670000269 DNA-binding site [nucleotide binding]; DNA binding site 768670000270 RNA-binding motif; other site 768670000271 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 768670000272 DNA-binding site [nucleotide binding]; DNA binding site 768670000273 RNA-binding motif; other site 768670000274 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 768670000275 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 768670000276 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 768670000277 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 768670000278 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 768670000279 NAD(P) binding site [chemical binding]; other site 768670000280 catalytic residues [active] 768670000281 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 768670000282 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 768670000283 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 768670000284 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 768670000285 PilZ domain; Region: PilZ; pfam07238 768670000286 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 768670000287 Predicted membrane protein [Function unknown]; Region: COG2855 768670000288 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 768670000289 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768670000290 NAD(P) binding site [chemical binding]; other site 768670000291 active site 768670000292 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 768670000293 photolyase PhrII; Region: phr2; TIGR00591 768670000294 DNA photolyase; Region: DNA_photolyase; pfam00875 768670000295 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 768670000296 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 768670000297 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 768670000298 Walker A/P-loop; other site 768670000299 ATP binding site [chemical binding]; other site 768670000300 Q-loop/lid; other site 768670000301 ABC transporter signature motif; other site 768670000302 Walker B; other site 768670000303 D-loop; other site 768670000304 H-loop/switch region; other site 768670000305 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 768670000306 FtsX-like permease family; Region: FtsX; pfam02687 768670000307 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 768670000308 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 768670000309 FtsX-like permease family; Region: FtsX; pfam02687 768670000310 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 768670000311 HD domain; Region: HD_3; pfam13023 768670000312 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 768670000313 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 768670000314 CoA-binding site [chemical binding]; other site 768670000315 ATP-binding [chemical binding]; other site 768670000316 Flagellin N-methylase; Region: FliB; cl00497 768670000317 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 768670000318 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 768670000319 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 768670000320 YceG-like family; Region: YceG; pfam02618 768670000321 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 768670000322 dimerization interface [polypeptide binding]; other site 768670000323 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 768670000324 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 768670000325 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 768670000326 catalytic site [active] 768670000327 subunit interface [polypeptide binding]; other site 768670000328 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 768670000329 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 768670000330 hypothetical protein; Provisional; Region: PRK10621 768670000331 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 768670000332 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 768670000333 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 768670000334 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 768670000335 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 768670000336 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 768670000337 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 768670000338 Organic solvent tolerance protein; Region: OstA_C; pfam04453 768670000339 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 768670000340 extended (e) SDRs; Region: SDR_e; cd08946 768670000341 NAD(P) binding site [chemical binding]; other site 768670000342 active site 768670000343 substrate binding site [chemical binding]; other site 768670000344 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 768670000345 DHH family; Region: DHH; pfam01368 768670000346 Rubredoxin [Energy production and conversion]; Region: COG1773 768670000347 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 768670000348 iron binding site [ion binding]; other site 768670000349 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 768670000350 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 768670000351 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 768670000352 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 768670000353 DHH family; Region: DHH; pfam01368 768670000354 Membrane protein of unknown function (DUF340); Region: DUF340; pfam03956 768670000355 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 768670000356 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 768670000357 tetramer interface [polypeptide binding]; other site 768670000358 active site 768670000359 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 768670000360 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 768670000361 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 768670000362 DctM-like transporters; Region: DctM; pfam06808 768670000363 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 768670000364 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869 768670000365 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 768670000366 DRTGG domain; Region: DRTGG; pfam07085 768670000367 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 768670000368 DHHA2 domain; Region: DHHA2; pfam02833 768670000369 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 768670000370 anti sigma factor interaction site; other site 768670000371 regulatory phosphorylation site [posttranslational modification]; other site 768670000372 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 768670000373 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768670000374 ATP binding site [chemical binding]; other site 768670000375 Mg2+ binding site [ion binding]; other site 768670000376 G-X-G motif; other site 768670000377 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 768670000378 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 768670000379 catalytic residues [active] 768670000380 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 768670000381 thiS-thiF/thiG interaction site; other site 768670000382 ThiS-like ubiquitin; Region: ThiS-like; pfam14453 768670000383 thiamine biosynthesis protein ThiF; Provisional; Region: PRK08644 768670000384 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 768670000385 ATP binding site [chemical binding]; other site 768670000386 substrate interface [chemical binding]; other site 768670000387 Peptidase family M48; Region: Peptidase_M48; cl12018 768670000388 Protein of unknown function DUF116; Region: DUF116; pfam01976 768670000389 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 768670000390 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 768670000391 putative active site [active] 768670000392 substrate binding site [chemical binding]; other site 768670000393 putative cosubstrate binding site; other site 768670000394 catalytic site [active] 768670000395 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 768670000396 substrate binding site [chemical binding]; other site 768670000397 aspartate aminotransferase; Provisional; Region: PRK06290 768670000398 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768670000399 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768670000400 homodimer interface [polypeptide binding]; other site 768670000401 catalytic residue [active] 768670000402 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 768670000403 Radical SAM superfamily; Region: Radical_SAM; pfam04055 768670000404 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768670000405 RNA binding surface [nucleotide binding]; other site 768670000406 SurA N-terminal domain; Region: SurA_N; pfam09312 768670000407 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 768670000408 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 768670000409 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 768670000410 active site 768670000411 catalytic site [active] 768670000412 substrate binding site [chemical binding]; other site 768670000413 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 768670000414 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 768670000415 Sporulation related domain; Region: SPOR; pfam05036 768670000416 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 768670000417 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 768670000418 active site residue [active] 768670000419 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 768670000420 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 768670000421 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 768670000422 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 768670000423 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294 768670000424 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768670000425 dimerization interface [polypeptide binding]; other site 768670000426 putative DNA binding site [nucleotide binding]; other site 768670000427 putative Zn2+ binding site [ion binding]; other site 768670000428 Chorismate mutase type II; Region: CM_2; smart00830 768670000429 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 768670000430 Prephenate dehydratase; Region: PDT; pfam00800 768670000431 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 768670000432 putative L-Phe binding site [chemical binding]; other site 768670000433 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 768670000434 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768670000435 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768670000436 homodimer interface [polypeptide binding]; other site 768670000437 catalytic residue [active] 768670000438 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 768670000439 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 768670000440 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 768670000441 prephenate dehydrogenase; Validated; Region: PRK08507 768670000442 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 768670000443 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 768670000444 hinge; other site 768670000445 active site 768670000446 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 768670000447 cytidylate kinase; Provisional; Region: cmk; PRK00023 768670000448 CMP-binding site; other site 768670000449 The sites determining sugar specificity; other site 768670000450 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 768670000451 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 768670000452 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 768670000453 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 768670000454 RNA binding site [nucleotide binding]; other site 768670000455 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 768670000456 RNA binding site [nucleotide binding]; other site 768670000457 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164 768670000458 RNA binding site [nucleotide binding]; other site 768670000459 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 768670000460 RNA binding site [nucleotide binding]; other site 768670000461 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 768670000462 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 768670000463 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 768670000464 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 768670000465 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 768670000466 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 768670000467 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 768670000468 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768670000469 dimerization interface [polypeptide binding]; other site 768670000470 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 768670000471 dimer interface [polypeptide binding]; other site 768670000472 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 768670000473 putative CheW interface [polypeptide binding]; other site 768670000474 recombinase A; Provisional; Region: recA; PRK09354 768670000475 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 768670000476 hexamer interface [polypeptide binding]; other site 768670000477 Walker A motif; other site 768670000478 ATP binding site [chemical binding]; other site 768670000479 Walker B motif; other site 768670000480 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 768670000481 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 768670000482 Walker A motif; other site 768670000483 ATP binding site [chemical binding]; other site 768670000484 Walker B motif; other site 768670000485 RecX family; Region: RecX; cl00936 768670000486 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 768670000487 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 768670000488 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 768670000489 replicative DNA helicase; Region: DnaB; TIGR00665 768670000490 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 768670000491 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 768670000492 Walker A motif; other site 768670000493 ATP binding site [chemical binding]; other site 768670000494 Walker B motif; other site 768670000495 DNA binding loops [nucleotide binding] 768670000496 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 768670000497 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 768670000498 Uncharacterized membrane protein [Function unknown]; Region: SpmB; cl17667 768670000499 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 768670000500 dimer interface [polypeptide binding]; other site 768670000501 substrate binding site [chemical binding]; other site 768670000502 ATP binding site [chemical binding]; other site 768670000503 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 768670000504 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 768670000505 active site 768670000506 PHP Thumb interface [polypeptide binding]; other site 768670000507 metal binding site [ion binding]; metal-binding site 768670000508 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 768670000509 generic binding surface II; other site 768670000510 generic binding surface I; other site 768670000511 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 768670000512 Walker A motif; other site 768670000513 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 768670000514 MULE transposase domain; Region: MULE; pfam10551 768670000515 Transposase; Region: DDE_Tnp_ISL3; pfam01610 768670000516 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 768670000517 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 768670000518 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 768670000519 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 768670000520 Probable Catalytic site; other site 768670000521 Uncharacterized conserved protein [Function unknown]; Region: COG0398 768670000522 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 768670000523 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 768670000524 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768670000525 FeS/SAM binding site; other site 768670000526 Radical SAM superfamily; Region: Radical_SAM; pfam04055 768670000527 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 768670000528 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 768670000529 active site residue [active] 768670000530 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768670000531 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768670000532 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 768670000533 dimerization interface [polypeptide binding]; other site 768670000534 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 768670000535 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768670000536 Walker A/P-loop; other site 768670000537 ATP binding site [chemical binding]; other site 768670000538 Q-loop/lid; other site 768670000539 ABC transporter signature motif; other site 768670000540 Walker B; other site 768670000541 D-loop; other site 768670000542 H-loop/switch region; other site 768670000543 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 768670000544 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 768670000545 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 768670000546 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 768670000547 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 768670000548 NAD(P) binding site [chemical binding]; other site 768670000549 homodimer interface [polypeptide binding]; other site 768670000550 substrate binding site [chemical binding]; other site 768670000551 active site 768670000552 Uncharacterized membrane protein, required for N-linked glycosylation [General function prediction only]; Region: COG1287 768670000553 Uncharacterized membrane protein, required for N-linked glycosylation [General function prediction only]; Region: COG1287 768670000554 Bacterial sugar transferase; Region: Bac_transf; pfam02397 768670000555 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 768670000556 FAD binding domain; Region: FAD_binding_4; pfam01565 768670000557 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 768670000558 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 768670000559 hypothetical protein; Provisional; Region: PRK10578 768670000560 UPF0126 domain; Region: UPF0126; pfam03458 768670000561 UPF0126 domain; Region: UPF0126; pfam03458 768670000562 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 768670000563 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 768670000564 Walker A/P-loop; other site 768670000565 ATP binding site [chemical binding]; other site 768670000566 Q-loop/lid; other site 768670000567 ABC transporter signature motif; other site 768670000568 Walker B; other site 768670000569 D-loop; other site 768670000570 H-loop/switch region; other site 768670000571 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 768670000572 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 768670000573 FtsX-like permease family; Region: FtsX; pfam02687 768670000574 GMP synthase; Reviewed; Region: guaA; PRK00074 768670000575 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 768670000576 AMP/PPi binding site [chemical binding]; other site 768670000577 candidate oxyanion hole; other site 768670000578 catalytic triad [active] 768670000579 potential glutamine specificity residues [chemical binding]; other site 768670000580 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 768670000581 ATP Binding subdomain [chemical binding]; other site 768670000582 Ligand Binding sites [chemical binding]; other site 768670000583 Dimerization subdomain; other site 768670000584 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 768670000585 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 768670000586 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 768670000587 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 768670000588 active site 768670000589 NAD synthetase; Provisional; Region: PRK13980 768670000590 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 768670000591 homodimer interface [polypeptide binding]; other site 768670000592 NAD binding pocket [chemical binding]; other site 768670000593 ATP binding pocket [chemical binding]; other site 768670000594 Mg binding site [ion binding]; other site 768670000595 active-site loop [active] 768670000596 Predicted amidohydrolase [General function prediction only]; Region: COG0388 768670000597 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_8; cd07586 768670000598 putative active site [active] 768670000599 catalytic triad [active] 768670000600 putative dimer interface [polypeptide binding]; other site 768670000601 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 768670000602 trimer interface [polypeptide binding]; other site 768670000603 dimer interface [polypeptide binding]; other site 768670000604 putative active site [active] 768670000605 GTP-binding protein YchF; Reviewed; Region: PRK09601 768670000606 YchF GTPase; Region: YchF; cd01900 768670000607 G1 box; other site 768670000608 GTP/Mg2+ binding site [chemical binding]; other site 768670000609 Switch I region; other site 768670000610 G2 box; other site 768670000611 Switch II region; other site 768670000612 G3 box; other site 768670000613 G4 box; other site 768670000614 G5 box; other site 768670000615 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 768670000616 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 768670000617 HAMP domain; Region: HAMP; pfam00672 768670000618 dimerization interface [polypeptide binding]; other site 768670000619 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768670000620 dimer interface [polypeptide binding]; other site 768670000621 phosphorylation site [posttranslational modification] 768670000622 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768670000623 ATP binding site [chemical binding]; other site 768670000624 Mg2+ binding site [ion binding]; other site 768670000625 G-X-G motif; other site 768670000626 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768670000627 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768670000628 active site 768670000629 phosphorylation site [posttranslational modification] 768670000630 intermolecular recognition site; other site 768670000631 dimerization interface [polypeptide binding]; other site 768670000632 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768670000633 DNA binding site [nucleotide binding] 768670000634 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 768670000635 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 768670000636 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 768670000637 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 768670000638 heat shock protein 90; Provisional; Region: PRK05218 768670000639 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768670000640 ATP binding site [chemical binding]; other site 768670000641 Mg2+ binding site [ion binding]; other site 768670000642 G-X-G motif; other site 768670000643 conserved hypothetical protein; Region: TIGR02231 768670000644 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 768670000645 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 768670000646 Protein of unknown function (DUF2723); Region: DUF2723; pfam11028 768670000647 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 768670000648 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 768670000649 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 768670000650 putative active site [active] 768670000651 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 768670000652 Ligand binding site; other site 768670000653 Putative Catalytic site; other site 768670000654 DXD motif; other site 768670000655 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 768670000656 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 768670000657 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 768670000658 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 768670000659 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 768670000660 Probable Catalytic site; other site 768670000661 metal-binding site 768670000662 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA_subfamily_ECM; cd01450 768670000663 putative vWF-collagen binding site; other site 768670000664 glycoprotein Ib (GpIb) binding site [polypeptide binding]; other site 768670000665 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 768670000666 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 768670000667 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 768670000668 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 768670000669 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 768670000670 NAD binding site [chemical binding]; other site 768670000671 homodimer interface [polypeptide binding]; other site 768670000672 active site 768670000673 substrate binding site [chemical binding]; other site 768670000674 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 768670000675 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 768670000676 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 768670000677 Walker A/P-loop; other site 768670000678 ATP binding site [chemical binding]; other site 768670000679 Q-loop/lid; other site 768670000680 ABC transporter signature motif; other site 768670000681 Walker B; other site 768670000682 D-loop; other site 768670000683 H-loop/switch region; other site 768670000684 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 768670000685 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 768670000686 G1 box; other site 768670000687 putative GEF interaction site [polypeptide binding]; other site 768670000688 GTP/Mg2+ binding site [chemical binding]; other site 768670000689 Switch I region; other site 768670000690 G2 box; other site 768670000691 G3 box; other site 768670000692 Switch II region; other site 768670000693 G4 box; other site 768670000694 G5 box; other site 768670000695 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 768670000696 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 768670000697 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 768670000698 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768670000699 substrate binding pocket [chemical binding]; other site 768670000700 membrane-bound complex binding site; other site 768670000701 hinge residues; other site 768670000702 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 768670000703 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768670000704 putative active site [active] 768670000705 heme pocket [chemical binding]; other site 768670000706 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768670000707 dimer interface [polypeptide binding]; other site 768670000708 phosphorylation site [posttranslational modification] 768670000709 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768670000710 ATP binding site [chemical binding]; other site 768670000711 Mg2+ binding site [ion binding]; other site 768670000712 G-X-G motif; other site 768670000713 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768670000714 Response regulator receiver domain; Region: Response_reg; pfam00072 768670000715 active site 768670000716 phosphorylation site [posttranslational modification] 768670000717 intermolecular recognition site; other site 768670000718 dimerization interface [polypeptide binding]; other site 768670000719 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 768670000720 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 768670000721 putative active site [active] 768670000722 4Fe-4S binding domain; Region: Fer4_6; pfam12837 768670000723 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 768670000724 4Fe-4S binding domain; Region: Fer4; pfam00037 768670000725 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 768670000726 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 768670000727 active site 768670000728 FMN binding site [chemical binding]; other site 768670000729 substrate binding site [chemical binding]; other site 768670000730 3Fe-4S cluster binding site [ion binding]; other site 768670000731 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 768670000732 domain_subunit interface; other site 768670000733 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 768670000734 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 768670000735 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 768670000736 NAD(P) binding site [chemical binding]; other site 768670000737 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 768670000738 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768670000739 dimerization interface [polypeptide binding]; other site 768670000740 putative DNA binding site [nucleotide binding]; other site 768670000741 putative Zn2+ binding site [ion binding]; other site 768670000742 Predicted permease; Region: DUF318; cl17795 768670000743 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 768670000744 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 768670000745 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 768670000746 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 768670000747 Low molecular weight phosphatase family; Region: LMWPc; cd00115 768670000748 active site 768670000749 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 768670000750 Sodium Bile acid symporter family; Region: SBF; cl17470 768670000751 Predicted permeases [General function prediction only]; Region: COG0679 768670000752 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 768670000753 dimer interface [polypeptide binding]; other site 768670000754 active site 768670000755 Schiff base residues; other site 768670000756 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768670000757 Walker A motif; other site 768670000758 ATP binding site [chemical binding]; other site 768670000759 Walker B motif; other site 768670000760 arginine finger; other site 768670000761 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 768670000762 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 768670000763 thiosulfate reductase PhsA; Provisional; Region: PRK15488 768670000764 The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755 768670000765 putative [Fe4-S4] binding site [ion binding]; other site 768670000766 putative molybdopterin cofactor binding site [chemical binding]; other site 768670000767 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 768670000768 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 768670000769 The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778 768670000770 putative molybdopterin cofactor binding site; other site 768670000771 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 768670000772 4Fe-4S binding domain; Region: Fer4; pfam00037 768670000773 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 768670000774 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 768670000775 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 768670000776 anti sigma factor interaction site; other site 768670000777 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 768670000778 regulatory phosphorylation site [posttranslational modification]; other site 768670000779 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 768670000780 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 768670000781 putative active site [active] 768670000782 catalytic triad [active] 768670000783 putative dimer interface [polypeptide binding]; other site 768670000784 Cytochrome c; Region: Cytochrom_C; cl11414 768670000785 SurA N-terminal domain; Region: SurA_N_3; pfam13624 768670000786 periplasmic folding chaperone; Provisional; Region: PRK10788 768670000787 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 768670000788 ABC transporter substrate binding protein; Region: ABC_sub_bind; cl17301 768670000789 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768670000790 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 768670000791 putative active site [active] 768670000792 heme pocket [chemical binding]; other site 768670000793 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768670000794 ATP binding site [chemical binding]; other site 768670000795 Mg2+ binding site [ion binding]; other site 768670000796 G-X-G motif; other site 768670000797 Response regulator receiver domain; Region: Response_reg; pfam00072 768670000798 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768670000799 active site 768670000800 phosphorylation site [posttranslational modification] 768670000801 intermolecular recognition site; other site 768670000802 dimerization interface [polypeptide binding]; other site 768670000803 Isochorismatase family; Region: Isochorismatase; pfam00857 768670000804 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 768670000805 catalytic triad [active] 768670000806 dimer interface [polypeptide binding]; other site 768670000807 conserved cis-peptide bond; other site 768670000808 hypothetical protein; Provisional; Region: PRK04860 768670000809 SprT homologues; Region: SprT; cl01182 768670000810 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 768670000811 Transposase, Mutator family; Region: Transposase_mut; pfam00872 768670000812 MULE transposase domain; Region: MULE; pfam10551 768670000813 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768670000814 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768670000815 dimer interface [polypeptide binding]; other site 768670000816 phosphorylation site [posttranslational modification] 768670000817 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768670000818 ATP binding site [chemical binding]; other site 768670000819 G-X-G motif; other site 768670000820 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768670000821 Response regulator receiver domain; Region: Response_reg; pfam00072 768670000822 active site 768670000823 phosphorylation site [posttranslational modification] 768670000824 intermolecular recognition site; other site 768670000825 dimerization interface [polypeptide binding]; other site 768670000826 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 768670000827 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 768670000828 putative NAD(P) binding site [chemical binding]; other site 768670000829 putative active site [active] 768670000830 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 768670000831 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 768670000832 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 768670000833 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 768670000834 nudix motif; other site 768670000835 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 768670000836 Clp amino terminal domain; Region: Clp_N; pfam02861 768670000837 Clp amino terminal domain; Region: Clp_N; pfam02861 768670000838 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768670000839 Walker A motif; other site 768670000840 ATP binding site [chemical binding]; other site 768670000841 Walker B motif; other site 768670000842 arginine finger; other site 768670000843 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768670000844 Walker A motif; other site 768670000845 ATP binding site [chemical binding]; other site 768670000846 Walker B motif; other site 768670000847 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 768670000848 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 768670000849 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 768670000850 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 768670000851 Zn2+ binding site [ion binding]; other site 768670000852 Mg2+ binding site [ion binding]; other site 768670000853 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 768670000854 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 768670000855 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 768670000856 active site 768670000857 catalytic residues [active] 768670000858 metal binding site [ion binding]; metal-binding site 768670000859 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 768670000860 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 768670000861 dimerization interface [polypeptide binding]; other site 768670000862 ligand binding site [chemical binding]; other site 768670000863 NADP binding site [chemical binding]; other site 768670000864 catalytic site [active] 768670000865 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 768670000866 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 768670000867 tandem repeat interface [polypeptide binding]; other site 768670000868 oligomer interface [polypeptide binding]; other site 768670000869 active site residues [active] 768670000870 Hemerythrin; Region: Hemerythrin; cd12107 768670000871 Fe binding site [ion binding]; other site 768670000872 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 768670000873 Na binding site [ion binding]; other site 768670000874 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 768670000875 putative ADP-ribose binding site [chemical binding]; other site 768670000876 putative active site [active] 768670000877 Predicted amidohydrolase [General function prediction only]; Region: COG0388 768670000878 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 768670000879 active site 768670000880 catalytic triad [active] 768670000881 dimer interface [polypeptide binding]; other site 768670000882 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 768670000883 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 768670000884 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 768670000885 Predicted permeases [General function prediction only]; Region: COG0679 768670000886 carbon storage regulator; Provisional; Region: PRK01712 768670000887 flagellar assembly protein FliW; Provisional; Region: PRK13285 768670000888 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 768670000889 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08471 768670000890 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 768670000891 FlgN protein; Region: FlgN; pfam05130 768670000892 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 768670000893 Rod binding protein; Region: Rod-binding; cl01626 768670000894 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 768670000895 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 768670000896 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12696 768670000897 Flagellar L-ring protein; Region: FlgH; pfam02107 768670000898 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 768670000899 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 768670000900 NMD3 family; Region: NMD3; pfam04981 768670000901 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 768670000902 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 768670000903 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768670000904 Walker A motif; other site 768670000905 ATP binding site [chemical binding]; other site 768670000906 Walker B motif; other site 768670000907 arginine finger; other site 768670000908 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 768670000909 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 768670000910 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 768670000911 ADP binding site [chemical binding]; other site 768670000912 magnesium binding site [ion binding]; other site 768670000913 putative shikimate binding site; other site 768670000914 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 768670000915 active site 768670000916 dimer interface [polypeptide binding]; other site 768670000917 metal binding site [ion binding]; metal-binding site 768670000918 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768670000919 TPR motif; other site 768670000920 binding surface 768670000921 Tetratricopeptide repeat; Region: TPR_16; pfam13432 768670000922 Tetratricopeptide repeat; Region: TPR_16; pfam13432 768670000923 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 768670000924 Dehydroquinase class II; Region: DHquinase_II; pfam01220 768670000925 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 768670000926 trimer interface [polypeptide binding]; other site 768670000927 active site 768670000928 dimer interface [polypeptide binding]; other site 768670000929 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 768670000930 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 768670000931 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 768670000932 active site 768670000933 elongation factor P; Validated; Region: PRK00529 768670000934 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 768670000935 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 768670000936 RNA binding site [nucleotide binding]; other site 768670000937 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 768670000938 RNA binding site [nucleotide binding]; other site 768670000939 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 768670000940 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 768670000941 carboxyltransferase (CT) interaction site; other site 768670000942 biotinylation site [posttranslational modification]; other site 768670000943 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 768670000944 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 768670000945 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 768670000946 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 768670000947 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768670000948 binding surface 768670000949 TPR motif; other site 768670000950 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768670000951 binding surface 768670000952 TPR motif; other site 768670000953 TPR repeat; Region: TPR_11; pfam13414 768670000954 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768670000955 binding surface 768670000956 TPR motif; other site 768670000957 TPR repeat; Region: TPR_11; pfam13414 768670000958 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768670000959 binding surface 768670000960 TPR motif; other site 768670000961 Tetratricopeptide repeat; Region: TPR_16; pfam13432 768670000962 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 768670000963 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 768670000964 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 768670000965 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 768670000966 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768670000967 active site 768670000968 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 768670000969 putative active site [active] 768670000970 catalytic residue [active] 768670000971 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 768670000972 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 768670000973 MgtC family; Region: MgtC; pfam02308 768670000974 Predicted membrane protein [Function unknown]; Region: COG3174 768670000975 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 768670000976 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 768670000977 EamA-like transporter family; Region: EamA; pfam00892 768670000978 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 768670000979 EamA-like transporter family; Region: EamA; pfam00892 768670000980 EamA-like transporter family; Region: EamA; pfam00892 768670000981 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 768670000982 EamA-like transporter family; Region: EamA; pfam00892 768670000983 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 768670000984 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 768670000985 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 768670000986 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 768670000987 substrate binding pocket [chemical binding]; other site 768670000988 dimer interface [polypeptide binding]; other site 768670000989 inhibitor binding site; inhibition site 768670000990 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 768670000991 B12 binding site [chemical binding]; other site 768670000992 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 768670000993 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 768670000994 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 768670000995 active site 768670000996 HIGH motif; other site 768670000997 nucleotide binding site [chemical binding]; other site 768670000998 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 768670000999 KMSKS motif; other site 768670001000 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 768670001001 Uncharacterized conserved protein [Function unknown]; Region: COG1434 768670001002 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 768670001003 putative active site [active] 768670001004 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 768670001005 GrpE; Region: GrpE; pfam01025 768670001006 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 768670001007 dimer interface [polypeptide binding]; other site 768670001008 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 768670001009 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 768670001010 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 768670001011 nucleotide binding site [chemical binding]; other site 768670001012 NEF interaction site [polypeptide binding]; other site 768670001013 SBD interface [polypeptide binding]; other site 768670001014 chaperone protein DnaJ; Provisional; Region: PRK10767 768670001015 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 768670001016 HSP70 interaction site [polypeptide binding]; other site 768670001017 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 768670001018 Zn binding sites [ion binding]; other site 768670001019 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 768670001020 dimer interface [polypeptide binding]; other site 768670001021 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 768670001022 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768670001023 active site 768670001024 phosphorylation site [posttranslational modification] 768670001025 intermolecular recognition site; other site 768670001026 dimerization interface [polypeptide binding]; other site 768670001027 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768670001028 Walker A motif; other site 768670001029 ATP binding site [chemical binding]; other site 768670001030 Walker B motif; other site 768670001031 arginine finger; other site 768670001032 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 768670001033 argininosuccinate lyase; Provisional; Region: PRK00855 768670001034 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 768670001035 active sites [active] 768670001036 tetramer interface [polypeptide binding]; other site 768670001037 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 768670001038 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 768670001039 dimer interface [polypeptide binding]; other site 768670001040 putative CheW interface [polypeptide binding]; other site 768670001041 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 768670001042 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768670001043 Methyltransferase domain; Region: Methyltransf_23; pfam13489 768670001044 S-adenosylmethionine binding site [chemical binding]; other site 768670001045 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768670001046 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768670001047 dimerization interface [polypeptide binding]; other site 768670001048 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768670001049 dimer interface [polypeptide binding]; other site 768670001050 phosphorylation site [posttranslational modification] 768670001051 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768670001052 ATP binding site [chemical binding]; other site 768670001053 Mg2+ binding site [ion binding]; other site 768670001054 G-X-G motif; other site 768670001055 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 768670001056 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768670001057 active site 768670001058 phosphorylation site [posttranslational modification] 768670001059 intermolecular recognition site; other site 768670001060 dimerization interface [polypeptide binding]; other site 768670001061 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768670001062 Walker A motif; other site 768670001063 ATP binding site [chemical binding]; other site 768670001064 Walker B motif; other site 768670001065 arginine finger; other site 768670001066 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 768670001067 protein-L-isoaspartate(D-aspartate) O-methyltransferase; Region: pimt; TIGR00080 768670001068 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 768670001069 S-adenosylmethionine binding site [chemical binding]; other site 768670001070 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 768670001071 feedback inhibition sensing region; other site 768670001072 homohexameric interface [polypeptide binding]; other site 768670001073 nucleotide binding site [chemical binding]; other site 768670001074 N-acetyl-L-glutamate binding site [chemical binding]; other site 768670001075 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 768670001076 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768670001077 Domain of unknown function (DUF4213); Region: DUF4213; pfam13938 768670001078 Domain of unknown function (DUF364); Region: DUF364; pfam04016 768670001079 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 768670001080 metal binding site [ion binding]; metal-binding site 768670001081 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 768670001082 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 768670001083 substrate binding site [chemical binding]; other site 768670001084 glutamase interaction surface [polypeptide binding]; other site 768670001085 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 768670001086 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768670001087 active site 768670001088 phosphorylation site [posttranslational modification] 768670001089 intermolecular recognition site; other site 768670001090 dimerization interface [polypeptide binding]; other site 768670001091 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768670001092 dimer interface [polypeptide binding]; other site 768670001093 phosphorylation site [posttranslational modification] 768670001094 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768670001095 ATP binding site [chemical binding]; other site 768670001096 Mg2+ binding site [ion binding]; other site 768670001097 G-X-G motif; other site 768670001098 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 768670001099 Flagellar protein YcgR; Region: YcgR_2; pfam12945 768670001100 PilZ domain; Region: PilZ; pfam07238 768670001101 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 768670001102 anti sigma factor interaction site; other site 768670001103 regulatory phosphorylation site [posttranslational modification]; other site 768670001104 Methyltransferase domain; Region: Methyltransf_31; pfam13847 768670001105 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768670001106 S-adenosylmethionine binding site [chemical binding]; other site 768670001107 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 768670001108 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768670001109 FeS/SAM binding site; other site 768670001110 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 768670001111 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 768670001112 catalytic triad [active] 768670001113 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 768670001114 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 768670001115 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 768670001116 substrate binding pocket [chemical binding]; other site 768670001117 chain length determination region; other site 768670001118 substrate-Mg2+ binding site; other site 768670001119 catalytic residues [active] 768670001120 aspartate-rich region 1; other site 768670001121 active site lid residues [active] 768670001122 aspartate-rich region 2; other site 768670001123 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 768670001124 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 768670001125 TPP-binding site; other site 768670001126 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 768670001127 PYR/PP interface [polypeptide binding]; other site 768670001128 dimer interface [polypeptide binding]; other site 768670001129 TPP binding site [chemical binding]; other site 768670001130 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 768670001131 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 768670001132 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768670001133 RNA binding surface [nucleotide binding]; other site 768670001134 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768670001135 S-adenosylmethionine binding site [chemical binding]; other site 768670001136 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 768670001137 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 768670001138 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 768670001139 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 768670001140 Walker A/P-loop; other site 768670001141 ATP binding site [chemical binding]; other site 768670001142 Q-loop/lid; other site 768670001143 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 768670001144 ABC transporter signature motif; other site 768670001145 Walker B; other site 768670001146 D-loop; other site 768670001147 H-loop/switch region; other site 768670001148 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 768670001149 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 768670001150 putative peptidase; Provisional; Region: PRK11649 768670001151 Peptidase family M23; Region: Peptidase_M23; pfam01551 768670001152 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 768670001153 transmembrane helices; other site 768670001154 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 768670001155 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 768670001156 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 768670001157 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 768670001158 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 768670001159 dimer interface [polypeptide binding]; other site 768670001160 PYR/PP interface [polypeptide binding]; other site 768670001161 TPP binding site [chemical binding]; other site 768670001162 substrate binding site [chemical binding]; other site 768670001163 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 768670001164 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 768670001165 TPP-binding site [chemical binding]; other site 768670001166 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 768670001167 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 768670001168 Acylphosphatase; Region: Acylphosphatase; pfam00708 768670001169 Predicted permeases [General function prediction only]; Region: COG0679 768670001170 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 768670001171 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 768670001172 AMP-binding domain protein; Validated; Region: PRK08315 768670001173 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 768670001174 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 768670001175 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 768670001176 acyl-activating enzyme (AAE) consensus motif; other site 768670001177 putative AMP binding site [chemical binding]; other site 768670001178 putative active site [active] 768670001179 acyl-activating enzyme (AAE) consensus motif; other site 768670001180 putative CoA binding site [chemical binding]; other site 768670001181 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 768670001182 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 768670001183 active site 768670001184 acyl-activating enzyme (AAE) consensus motif; other site 768670001185 putative CoA binding site [chemical binding]; other site 768670001186 AMP binding site [chemical binding]; other site 768670001187 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 768670001188 transcription termination factor Rho; Provisional; Region: rho; PRK09376 768670001189 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 768670001190 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 768670001191 RNA binding site [nucleotide binding]; other site 768670001192 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 768670001193 multimer interface [polypeptide binding]; other site 768670001194 Walker A motif; other site 768670001195 ATP binding site [chemical binding]; other site 768670001196 Walker B motif; other site 768670001197 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 768670001198 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 768670001199 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 768670001200 peptide chain release factor 1; Validated; Region: prfA; PRK00591 768670001201 This domain is found in peptide chain release factors; Region: PCRF; smart00937 768670001202 RF-1 domain; Region: RF-1; pfam00472 768670001203 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 768670001204 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768670001205 S-adenosylmethionine binding site [chemical binding]; other site 768670001206 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 768670001207 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 768670001208 hinge; other site 768670001209 active site 768670001210 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 768670001211 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 768670001212 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 768670001213 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 768670001214 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 768670001215 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 768670001216 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 768670001217 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 768670001218 Surface antigen; Region: Bac_surface_Ag; pfam01103 768670001219 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 768670001220 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 768670001221 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 768670001222 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 768670001223 trimer interface [polypeptide binding]; other site 768670001224 active site 768670001225 UDP-GlcNAc binding site [chemical binding]; other site 768670001226 lipid binding site [chemical binding]; lipid-binding site 768670001227 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 768670001228 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 768670001229 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 768670001230 active site 768670001231 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 768670001232 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 768670001233 Protein of unknown function (DUF1009); Region: DUF1009; pfam06230 768670001234 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 768670001235 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 768670001236 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 768670001237 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 768670001238 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 768670001239 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 768670001240 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 768670001241 active site 768670001242 HIGH motif; other site 768670001243 dimer interface [polypeptide binding]; other site 768670001244 KMSKS motif; other site 768670001245 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768670001246 RNA binding surface [nucleotide binding]; other site 768670001247 Uncharacterized conserved protein [Function unknown]; Region: COG4198 768670001248 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 768670001249 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 768670001250 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768670001251 RNA binding surface [nucleotide binding]; other site 768670001252 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 768670001253 active site 768670001254 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 768670001255 NADH dehydrogenase subunit B; Validated; Region: PRK06411 768670001256 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 768670001257 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 768670001258 NADH dehydrogenase subunit D; Validated; Region: PRK06075 768670001259 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 768670001260 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 768670001261 putative dimer interface [polypeptide binding]; other site 768670001262 [2Fe-2S] cluster binding site [ion binding]; other site 768670001263 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 768670001264 dimer interface [polypeptide binding]; other site 768670001265 [2Fe-2S] cluster binding site [ion binding]; other site 768670001266 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 768670001267 SLBB domain; Region: SLBB; pfam10531 768670001268 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 768670001269 4Fe-4S binding domain; Region: Fer4; pfam00037 768670001270 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 768670001271 4Fe-4S binding domain; Region: Fer4_6; pfam12837 768670001272 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 768670001273 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 768670001274 catalytic loop [active] 768670001275 iron binding site [ion binding]; other site 768670001276 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 768670001277 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 768670001278 molybdopterin cofactor binding site; other site 768670001279 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775 768670001280 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768670001281 binding surface 768670001282 TPR motif; other site 768670001283 TPR repeat; Region: TPR_11; pfam13414 768670001284 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768670001285 binding surface 768670001286 TPR motif; other site 768670001287 TPR repeat; Region: TPR_11; pfam13414 768670001288 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 768670001289 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 768670001290 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 768670001291 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 768670001292 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 768670001293 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 768670001294 NADH dehydrogenase subunit J; Provisional; Region: PRK06439 768670001295 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 768670001296 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 768670001297 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 768670001298 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 768670001299 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 768670001300 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 768670001301 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 768670001302 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 768670001303 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 768670001304 diiron binding motif [ion binding]; other site 768670001305 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 768670001306 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 768670001307 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 768670001308 dimer interface [polypeptide binding]; other site 768670001309 motif 1; other site 768670001310 active site 768670001311 motif 2; other site 768670001312 motif 3; other site 768670001313 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 768670001314 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 768670001315 putative tRNA-binding site [nucleotide binding]; other site 768670001316 B3/4 domain; Region: B3_4; pfam03483 768670001317 tRNA synthetase B5 domain; Region: B5; smart00874 768670001318 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 768670001319 dimer interface [polypeptide binding]; other site 768670001320 motif 1; other site 768670001321 motif 3; other site 768670001322 motif 2; other site 768670001323 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 768670001324 recombination factor protein RarA; Reviewed; Region: PRK13342 768670001325 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768670001326 Walker A motif; other site 768670001327 ATP binding site [chemical binding]; other site 768670001328 Walker B motif; other site 768670001329 arginine finger; other site 768670001330 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 768670001331 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 768670001332 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 768670001333 phosphodiesterase; Provisional; Region: PRK12704 768670001334 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 768670001335 Zn2+ binding site [ion binding]; other site 768670001336 Mg2+ binding site [ion binding]; other site 768670001337 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 768670001338 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 768670001339 putative active site [active] 768670001340 metal binding site [ion binding]; metal-binding site 768670001341 homodimer binding site [polypeptide binding]; other site 768670001342 Quinolinate synthetase A protein; Region: NadA; pfam02445 768670001343 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 768670001344 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768670001345 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768670001346 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 768670001347 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 768670001348 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; pfam03349 768670001349 Chalcone-flavanone isomerase; Region: Chalcone; cl03589 768670001350 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 768670001351 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 768670001352 substrate binding site [chemical binding]; other site 768670001353 oxyanion hole (OAH) forming residues; other site 768670001354 trimer interface [polypeptide binding]; other site 768670001355 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 768670001356 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 768670001357 FAD binding site [chemical binding]; other site 768670001358 homotetramer interface [polypeptide binding]; other site 768670001359 substrate binding pocket [chemical binding]; other site 768670001360 catalytic base [active] 768670001361 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 768670001362 4Fe-4S binding domain; Region: Fer4; cl02805 768670001363 Cysteine-rich domain; Region: CCG; pfam02754 768670001364 Cysteine-rich domain; Region: CCG; pfam02754 768670001365 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 768670001366 Ligand binding site [chemical binding]; other site 768670001367 Electron transfer flavoprotein domain; Region: ETF; pfam01012 768670001368 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 768670001369 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 768670001370 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 768670001371 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 768670001372 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 768670001373 FMN binding site [chemical binding]; other site 768670001374 substrate binding site [chemical binding]; other site 768670001375 putative catalytic residue [active] 768670001376 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 768670001377 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 768670001378 acyl-activating enzyme (AAE) consensus motif; other site 768670001379 putative AMP binding site [chemical binding]; other site 768670001380 putative active site [active] 768670001381 putative CoA binding site [chemical binding]; other site 768670001382 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 768670001383 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 768670001384 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 768670001385 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 768670001386 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 768670001387 substrate binding site [chemical binding]; other site 768670001388 oxyanion hole (OAH) forming residues; other site 768670001389 trimer interface [polypeptide binding]; other site 768670001390 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 768670001391 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 768670001392 dimer interface [polypeptide binding]; other site 768670001393 active site 768670001394 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 768670001395 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 768670001396 active site 768670001397 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 768670001398 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 768670001399 CoA-ligase; Region: Ligase_CoA; pfam00549 768670001400 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 768670001401 CoA binding domain; Region: CoA_binding; smart00881 768670001402 CoA-ligase; Region: Ligase_CoA; pfam00549 768670001403 PilZ domain; Region: PilZ; pfam07238 768670001404 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 768670001405 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 768670001406 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 768670001407 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 768670001408 MPN+ (JAMM) motif; other site 768670001409 Zinc-binding site [ion binding]; other site 768670001410 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 768670001411 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 768670001412 putative NAD(P) binding site [chemical binding]; other site 768670001413 active site 768670001414 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 768670001415 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768670001416 metal binding site [ion binding]; metal-binding site 768670001417 active site 768670001418 I-site; other site 768670001419 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 768670001420 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 768670001421 dimer interface [polypeptide binding]; other site 768670001422 putative anticodon binding site; other site 768670001423 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 768670001424 motif 1; other site 768670001425 active site 768670001426 motif 2; other site 768670001427 motif 3; other site 768670001428 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 768670001429 active site 768670001430 metal binding site [ion binding]; metal-binding site 768670001431 homotetramer interface [polypeptide binding]; other site 768670001432 rod shape-determining protein MreB; Provisional; Region: PRK13927 768670001433 MreB and similar proteins; Region: MreB_like; cd10225 768670001434 nucleotide binding site [chemical binding]; other site 768670001435 Mg binding site [ion binding]; other site 768670001436 putative protofilament interaction site [polypeptide binding]; other site 768670001437 RodZ interaction site [polypeptide binding]; other site 768670001438 rod shape-determining protein MreC; Provisional; Region: PRK13922 768670001439 rod shape-determining protein MreC; Region: MreC; pfam04085 768670001440 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 768670001441 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 768670001442 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 768670001443 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 768670001444 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 768670001445 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768670001446 FeS/SAM binding site; other site 768670001447 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 768670001448 ferric uptake regulator; Provisional; Region: fur; PRK09462 768670001449 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 768670001450 metal binding site 2 [ion binding]; metal-binding site 768670001451 putative DNA binding helix; other site 768670001452 metal binding site 1 [ion binding]; metal-binding site 768670001453 dimer interface [polypeptide binding]; other site 768670001454 structural Zn2+ binding site [ion binding]; other site 768670001455 Protein of unknown function (DUF2400); Region: DUF2400; pfam09674 768670001456 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 768670001457 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 768670001458 catalytic residues [active] 768670001459 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 768670001460 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 768670001461 IHF dimer interface [polypeptide binding]; other site 768670001462 IHF - DNA interface [nucleotide binding]; other site 768670001463 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 768670001464 homodimer interface [polypeptide binding]; other site 768670001465 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768670001466 catalytic residue [active] 768670001467 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 768670001468 dimer interface [polypeptide binding]; other site 768670001469 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 768670001470 motif 1; other site 768670001471 active site 768670001472 motif 2; other site 768670001473 motif 3; other site 768670001474 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 768670001475 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 768670001476 GDP-binding site [chemical binding]; other site 768670001477 ACT binding site; other site 768670001478 IMP binding site; other site 768670001479 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 768670001480 SmpB-tmRNA interface; other site 768670001481 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 768670001482 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 768670001483 ligand binding site [chemical binding]; other site 768670001484 flexible hinge region; other site 768670001485 fumarate hydratase; Reviewed; Region: fumC; PRK00485 768670001486 Class II fumarases; Region: Fumarase_classII; cd01362 768670001487 active site 768670001488 tetramer interface [polypeptide binding]; other site 768670001489 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 768670001490 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 768670001491 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 768670001492 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 768670001493 putative active site [active] 768670001494 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 768670001495 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 768670001496 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 768670001497 DctM-like transporters; Region: DctM; pfam06808 768670001498 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 768670001499 Response regulator receiver domain; Region: Response_reg; pfam00072 768670001500 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768670001501 active site 768670001502 phosphorylation site [posttranslational modification] 768670001503 intermolecular recognition site; other site 768670001504 dimerization interface [polypeptide binding]; other site 768670001505 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 768670001506 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 768670001507 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 768670001508 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 768670001509 DctM-like transporters; Region: DctM; pfam06808 768670001510 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 768670001511 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 768670001512 dimerization interface 3.5A [polypeptide binding]; other site 768670001513 active site 768670001514 twin arginine translocase protein A; Provisional; Region: tatA; PRK14859 768670001515 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 768670001516 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 768670001517 PilX N-terminal; Region: PilX_N; pfam14341 768670001518 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 768670001519 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768670001520 Walker A motif; other site 768670001521 ATP binding site [chemical binding]; other site 768670001522 Walker B motif; other site 768670001523 arginine finger; other site 768670001524 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 768670001525 binding surface 768670001526 TPR motif; other site 768670001527 Competence protein A; Region: Competence_A; pfam11104 768670001528 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 768670001529 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 768670001530 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 768670001531 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 768670001532 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 768670001533 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768670001534 binding surface 768670001535 TPR motif; other site 768670001536 putative GTP cyclohydrolase; Provisional; Region: PRK13674 768670001537 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 768670001538 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 768670001539 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 768670001540 Walker A motif; other site 768670001541 ATP binding site [chemical binding]; other site 768670001542 Walker B motif; other site 768670001543 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 768670001544 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 768670001545 active site 768670001546 HIGH motif; other site 768670001547 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 768670001548 KMSKS motif; other site 768670001549 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 768670001550 tRNA binding surface [nucleotide binding]; other site 768670001551 anticodon binding site; other site 768670001552 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 768670001553 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768670001554 NAD(P) binding site [chemical binding]; other site 768670001555 active site 768670001556 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 768670001557 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 768670001558 Substrate binding site; other site 768670001559 Mg++ binding site; other site 768670001560 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 768670001561 active site 768670001562 substrate binding site [chemical binding]; other site 768670001563 CoA binding site [chemical binding]; other site 768670001564 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 768670001565 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 768670001566 glutaminase active site [active] 768670001567 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 768670001568 dimer interface [polypeptide binding]; other site 768670001569 active site 768670001570 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 768670001571 dimer interface [polypeptide binding]; other site 768670001572 active site 768670001573 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 768670001574 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 768670001575 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 768670001576 catalytic residues [active] 768670001577 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 768670001578 legume lectins; Region: lectin_L-type; cl14058 768670001579 homotetramer interaction site [polypeptide binding]; other site 768670001580 homodimer interaction site [polypeptide binding]; other site 768670001581 carbohydrate binding site [chemical binding]; other site 768670001582 metal binding site [ion binding]; metal-binding site 768670001583 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 768670001584 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 768670001585 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 768670001586 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 768670001587 transketolase; Reviewed; Region: PRK05899 768670001588 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 768670001589 TPP-binding site [chemical binding]; other site 768670001590 dimer interface [polypeptide binding]; other site 768670001591 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 768670001592 PYR/PP interface [polypeptide binding]; other site 768670001593 dimer interface [polypeptide binding]; other site 768670001594 TPP binding site [chemical binding]; other site 768670001595 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 768670001596 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 768670001597 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 768670001598 nucleotide binding site/active site [active] 768670001599 HIT family signature motif; other site 768670001600 catalytic residue [active] 768670001601 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 768670001602 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 768670001603 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 768670001604 MutS domain I; Region: MutS_I; pfam01624 768670001605 MutS domain II; Region: MutS_II; pfam05188 768670001606 MutS domain III; Region: MutS_III; pfam05192 768670001607 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 768670001608 Walker A/P-loop; other site 768670001609 ATP binding site [chemical binding]; other site 768670001610 Q-loop/lid; other site 768670001611 ABC transporter signature motif; other site 768670001612 Walker B; other site 768670001613 D-loop; other site 768670001614 H-loop/switch region; other site 768670001615 Dam-replacing family; Region: DRP; pfam06044 768670001616 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 768670001617 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 768670001618 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768670001619 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 768670001620 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768670001621 DNA binding residues [nucleotide binding] 768670001622 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 768670001623 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 768670001624 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 768670001625 active site 768670001626 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 768670001627 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 768670001628 NADP binding site [chemical binding]; other site 768670001629 dimer interface [polypeptide binding]; other site 768670001630 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 768670001631 Na binding site [ion binding]; other site 768670001632 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 768670001633 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 768670001634 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 768670001635 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 768670001636 Zn2+ binding site [ion binding]; other site 768670001637 Mg2+ binding site [ion binding]; other site 768670001638 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 768670001639 Zn2+ binding site [ion binding]; other site 768670001640 Mg2+ binding site [ion binding]; other site 768670001641 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768670001642 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768670001643 ATP binding site [chemical binding]; other site 768670001644 Mg2+ binding site [ion binding]; other site 768670001645 G-X-G motif; other site 768670001646 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 768670001647 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768670001648 dimerization interface [polypeptide binding]; other site 768670001649 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 768670001650 dimer interface [polypeptide binding]; other site 768670001651 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 768670001652 putative CheW interface [polypeptide binding]; other site 768670001653 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 768670001654 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 768670001655 dimer interface [polypeptide binding]; other site 768670001656 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768670001657 catalytic residue [active] 768670001658 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 768670001659 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 768670001660 homodimer interface [polypeptide binding]; other site 768670001661 substrate-cofactor binding pocket; other site 768670001662 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768670001663 catalytic residue [active] 768670001664 Rrf2 family protein; Region: rrf2_super; TIGR00738 768670001665 Transcriptional regulator; Region: Rrf2; pfam02082 768670001666 Transcriptional regulator; Region: Rrf2; cl17282 768670001667 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 768670001668 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 768670001669 Walker A/P-loop; other site 768670001670 ATP binding site [chemical binding]; other site 768670001671 Q-loop/lid; other site 768670001672 ABC transporter signature motif; other site 768670001673 Walker B; other site 768670001674 D-loop; other site 768670001675 H-loop/switch region; other site 768670001676 Cobalt transport protein; Region: CbiQ; cl00463 768670001677 ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; cl00397 768670001678 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 768670001679 PDGLE domain; Region: PDGLE; pfam13190 768670001680 Ion channel; Region: Ion_trans_2; pfam07885 768670001681 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 768670001682 TrkA-N domain; Region: TrkA_N; pfam02254 768670001683 TrkA-C domain; Region: TrkA_C; pfam02080 768670001684 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 768670001685 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 768670001686 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 768670001687 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 768670001688 SAF-like; Region: SAF_2; pfam13144 768670001689 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 768670001690 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 768670001691 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768670001692 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768670001693 active site 768670001694 phosphorylation site [posttranslational modification] 768670001695 intermolecular recognition site; other site 768670001696 dimerization interface [polypeptide binding]; other site 768670001697 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768670001698 DNA binding site [nucleotide binding] 768670001699 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 768670001700 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768670001701 dimerization interface [polypeptide binding]; other site 768670001702 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768670001703 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768670001704 dimer interface [polypeptide binding]; other site 768670001705 phosphorylation site [posttranslational modification] 768670001706 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768670001707 ATP binding site [chemical binding]; other site 768670001708 G-X-G motif; other site 768670001709 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 768670001710 transcriptional activator RfaH; Region: RfaH; TIGR01955 768670001711 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 768670001712 heterodimer interface [polypeptide binding]; other site 768670001713 homodimer interface [polypeptide binding]; other site 768670001714 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 768670001715 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 768670001716 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 768670001717 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768670001718 active site 768670001719 phosphorylation site [posttranslational modification] 768670001720 intermolecular recognition site; other site 768670001721 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 768670001722 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 768670001723 metal binding site [ion binding]; metal-binding site 768670001724 dimer interface [polypeptide binding]; other site 768670001725 putative cation:proton antiport protein; Provisional; Region: PRK10669 768670001726 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 768670001727 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 768670001728 TrkA-N domain; Region: TrkA_N; pfam02254 768670001729 TrkA-C domain; Region: TrkA_C; pfam02080 768670001730 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 768670001731 zinc binding site [ion binding]; other site 768670001732 putative ligand binding site [chemical binding]; other site 768670001733 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768670001734 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 768670001735 TM-ABC transporter signature motif; other site 768670001736 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 768670001737 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768670001738 Walker A/P-loop; other site 768670001739 ATP binding site [chemical binding]; other site 768670001740 Q-loop/lid; other site 768670001741 ABC transporter signature motif; other site 768670001742 Walker B; other site 768670001743 D-loop; other site 768670001744 H-loop/switch region; other site 768670001745 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 768670001746 AAA domain; Region: AAA_23; pfam13476 768670001747 Walker A/P-loop; other site 768670001748 ATP binding site [chemical binding]; other site 768670001749 Q-loop/lid; other site 768670001750 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 768670001751 Q-loop/lid; other site 768670001752 ABC transporter signature motif; other site 768670001753 Walker B; other site 768670001754 D-loop; other site 768670001755 H-loop/switch region; other site 768670001756 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 768670001757 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 768670001758 malate dehydrogenase; Reviewed; Region: PRK06223 768670001759 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 768670001760 NAD(P) binding site [chemical binding]; other site 768670001761 dimer interface [polypeptide binding]; other site 768670001762 tetramer (dimer of dimers) interface [polypeptide binding]; other site 768670001763 substrate binding site [chemical binding]; other site 768670001764 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 768670001765 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 768670001766 2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659 768670001767 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 768670001768 dimer interface [polypeptide binding]; other site 768670001769 PYR/PP interface [polypeptide binding]; other site 768670001770 TPP binding site [chemical binding]; other site 768670001771 substrate binding site [chemical binding]; other site 768670001772 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 768670001773 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 768670001774 TPP-binding site [chemical binding]; other site 768670001775 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 768670001776 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 768670001777 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 768670001778 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 768670001779 HIGH motif; other site 768670001780 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 768670001781 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 768670001782 active site 768670001783 KMSKS motif; other site 768670001784 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 768670001785 tRNA binding surface [nucleotide binding]; other site 768670001786 Lipopolysaccharide-assembly; Region: LptE; cl01125 768670001787 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 768670001788 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 768670001789 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 768670001790 Peptidase family M23; Region: Peptidase_M23; pfam01551 768670001791 SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913 768670001792 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 768670001793 NlpC/P60 family; Region: NLPC_P60; cl17555 768670001794 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 768670001795 Domain of unknown function DUF20; Region: UPF0118; pfam01594 768670001796 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 768670001797 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 768670001798 active site 768670001799 Riboflavin kinase; Region: Flavokinase; pfam01687 768670001800 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 768670001801 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 768670001802 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768670001803 FeS/SAM binding site; other site 768670001804 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 768670001805 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 768670001806 binding surface 768670001807 TPR motif; other site 768670001808 seryl-tRNA synthetase; Provisional; Region: PRK05431 768670001809 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 768670001810 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 768670001811 dimer interface [polypeptide binding]; other site 768670001812 active site 768670001813 motif 1; other site 768670001814 motif 2; other site 768670001815 motif 3; other site 768670001816 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 768670001817 putative SAM binding site [chemical binding]; other site 768670001818 homodimer interface [polypeptide binding]; other site 768670001819 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 768670001820 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 768670001821 ligand binding site [chemical binding]; other site 768670001822 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800 768670001823 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 768670001824 metal binding triad; other site 768670001825 Domain of unknown function (DUF4212); Region: DUF4212; cl01781 768670001826 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 768670001827 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 768670001828 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 768670001829 Na binding site [ion binding]; other site 768670001830 Cytochrome c552; Region: Cytochrom_C552; pfam02335 768670001831 ResB-like family; Region: ResB; pfam05140 768670001832 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 768670001833 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 768670001834 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 768670001835 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768670001836 putative substrate translocation pore; other site 768670001837 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768670001838 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 768670001839 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768670001840 FeS/SAM binding site; other site 768670001841 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 768670001842 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 768670001843 ThiS interaction site; other site 768670001844 putative active site [active] 768670001845 tetramer interface [polypeptide binding]; other site 768670001846 2-isopropylmalate synthase; Validated; Region: PRK00915 768670001847 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 768670001848 active site 768670001849 catalytic residues [active] 768670001850 metal binding site [ion binding]; metal-binding site 768670001851 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 768670001852 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 768670001853 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 768670001854 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 768670001855 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 768670001856 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 768670001857 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 768670001858 N-acetyl-D-glucosamine binding site [chemical binding]; other site 768670001859 catalytic residue [active] 768670001860 pyruvate carboxylase; Reviewed; Region: PRK12999 768670001861 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 768670001862 ATP-grasp domain; Region: ATP-grasp_4; cl17255 768670001863 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 768670001864 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 768670001865 active site 768670001866 catalytic residues [active] 768670001867 metal binding site [ion binding]; metal-binding site 768670001868 homodimer binding site [polypeptide binding]; other site 768670001869 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 768670001870 carboxyltransferase (CT) interaction site; other site 768670001871 biotinylation site [posttranslational modification]; other site 768670001872 hybrid cluster protein; Provisional; Region: PRK05290 768670001873 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 768670001874 ACS interaction site; other site 768670001875 CODH interaction site; other site 768670001876 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 768670001877 hybrid metal cluster; other site 768670001878 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 768670001879 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 768670001880 ligand binding site [chemical binding]; other site 768670001881 flexible hinge region; other site 768670001882 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 768670001883 non-specific DNA interactions [nucleotide binding]; other site 768670001884 DNA binding site [nucleotide binding] 768670001885 sequence specific DNA binding site [nucleotide binding]; other site 768670001886 putative cAMP binding site [chemical binding]; other site 768670001887 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 768670001888 HAMP domain; Region: HAMP; pfam00672 768670001889 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 768670001890 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 768670001891 dimer interface [polypeptide binding]; other site 768670001892 putative CheW interface [polypeptide binding]; other site 768670001893 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 768670001894 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 768670001895 metal-binding site [ion binding] 768670001896 ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; cl00397 768670001897 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 768670001898 Soluble P-type ATPase [General function prediction only]; Region: COG4087 768670001899 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 768670001900 metal-binding site [ion binding] 768670001901 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 768670001902 Protein export membrane protein; Region: SecD_SecF; cl14618 768670001903 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 768670001904 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 768670001905 ligand binding site [chemical binding]; other site 768670001906 flexible hinge region; other site 768670001907 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 768670001908 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768670001909 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 768670001910 active site 768670001911 motif I; other site 768670001912 motif II; other site 768670001913 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 768670001914 putative acyl-acceptor binding pocket; other site 768670001915 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 768670001916 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 768670001917 putative acyl-acceptor binding pocket; other site 768670001918 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 768670001919 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 768670001920 inhibitor-cofactor binding pocket; inhibition site 768670001921 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768670001922 catalytic residue [active] 768670001923 PAS fold; Region: PAS_4; pfam08448 768670001924 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768670001925 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768670001926 phosphorylation site [posttranslational modification] 768670001927 dimer interface [polypeptide binding]; other site 768670001928 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768670001929 ATP binding site [chemical binding]; other site 768670001930 Mg2+ binding site [ion binding]; other site 768670001931 G-X-G motif; other site 768670001932 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 768670001933 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 768670001934 GTP binding site; other site 768670001935 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 768670001936 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 768670001937 active site 768670001938 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 768670001939 substrate binding site [chemical binding]; other site 768670001940 catalytic residues [active] 768670001941 dimer interface [polypeptide binding]; other site 768670001942 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 768670001943 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 768670001944 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 768670001945 dimer interface [polypeptide binding]; other site 768670001946 ssDNA binding site [nucleotide binding]; other site 768670001947 tetramer (dimer of dimers) interface [polypeptide binding]; other site 768670001948 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 768670001949 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 768670001950 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 768670001951 Cation efflux family; Region: Cation_efflux; cl00316 768670001952 FOG: CBS domain [General function prediction only]; Region: COG0517 768670001953 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 768670001954 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 768670001955 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 768670001956 transmembrane helices; other site 768670001957 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 768670001958 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 768670001959 MULE transposase domain; Region: MULE; pfam10551 768670001960 Transposase; Region: DDE_Tnp_ISL3; pfam01610 768670001961 Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899 768670001962 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599 768670001963 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 768670001964 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12504 768670001965 Domain of unknown function (DUF4040); Region: DUF4040; pfam13244 768670001966 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 768670001967 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 768670001968 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375 768670001969 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 768670001970 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 768670001971 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 768670001972 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 768670001973 Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion / Inorganic ion transport and metabolism]; Region: HyfB; COG0651 768670001974 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 768670001975 polyphosphate kinase; Provisional; Region: PRK05443 768670001976 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 768670001977 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 768670001978 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 768670001979 putative active site [active] 768670001980 catalytic site [active] 768670001981 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 768670001982 putative domain interface [polypeptide binding]; other site 768670001983 putative active site [active] 768670001984 catalytic site [active] 768670001985 exopolyphosphatase; Region: exo_poly_only; TIGR03706 768670001986 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 768670001987 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 768670001988 Zn2+ binding site [ion binding]; other site 768670001989 Mg2+ binding site [ion binding]; other site 768670001990 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 768670001991 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 768670001992 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 768670001993 Zn2+ binding site [ion binding]; other site 768670001994 Mg2+ binding site [ion binding]; other site 768670001995 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 768670001996 HSP70 interaction site [polypeptide binding]; other site 768670001997 TPR repeat; Region: TPR_11; pfam13414 768670001998 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768670001999 binding surface 768670002000 TPR motif; other site 768670002001 Tetratricopeptide repeat; Region: TPR_12; pfam13424 768670002002 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 768670002003 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 768670002004 TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666 768670002005 DctM-like transporters; Region: DctM; pfam06808 768670002006 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 768670002007 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 768670002008 active site 768670002009 nucleophile elbow; other site 768670002010 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 768670002011 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 768670002012 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 768670002013 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 768670002014 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 768670002015 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 768670002016 Walker A/P-loop; other site 768670002017 ATP binding site [chemical binding]; other site 768670002018 Q-loop/lid; other site 768670002019 ABC transporter signature motif; other site 768670002020 Walker B; other site 768670002021 D-loop; other site 768670002022 H-loop/switch region; other site 768670002023 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 768670002024 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 768670002025 Walker A/P-loop; other site 768670002026 ATP binding site [chemical binding]; other site 768670002027 Q-loop/lid; other site 768670002028 ABC transporter signature motif; other site 768670002029 Walker B; other site 768670002030 D-loop; other site 768670002031 H-loop/switch region; other site 768670002032 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 768670002033 HlyD family secretion protein; Region: HlyD_3; pfam13437 768670002034 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 768670002035 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 768670002036 catalytic core [active] 768670002037 multidrug efflux protein; Reviewed; Region: PRK01766 768670002038 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 768670002039 cation binding site [ion binding]; other site 768670002040 intracellular protease, PfpI family; Region: PfpI; TIGR01382 768670002041 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 768670002042 conserved cys residue [active] 768670002043 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 768670002044 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 768670002045 ligand binding site [chemical binding]; other site 768670002046 flexible hinge region; other site 768670002047 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 768670002048 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 768670002049 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 768670002050 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 768670002051 Protein of unknown function DUF58; Region: DUF58; pfam01882 768670002052 MoxR-like ATPases [General function prediction only]; Region: COG0714 768670002053 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768670002054 Walker A motif; other site 768670002055 ATP binding site [chemical binding]; other site 768670002056 Walker B motif; other site 768670002057 arginine finger; other site 768670002058 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 768670002059 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768670002060 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 768670002061 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 768670002062 putative substrate-binding site; other site 768670002063 nickel binding site [ion binding]; other site 768670002064 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 768670002065 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 768670002066 acyl-activating enzyme (AAE) consensus motif; other site 768670002067 putative AMP binding site [chemical binding]; other site 768670002068 putative active site [active] 768670002069 putative CoA binding site [chemical binding]; other site 768670002070 Maf-like protein; Region: Maf; pfam02545 768670002071 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 768670002072 active site 768670002073 dimer interface [polypeptide binding]; other site 768670002074 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 768670002075 NGN-insert domain found between N-terminal domain (D1) and C-terminal KOW domain (DIII) repeats of some N-Utilization Substance G (NusG) N-terminal (NGN); Region: NGN-insert_like; cd09910 768670002076 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 768670002077 ApbE family; Region: ApbE; pfam02424 768670002078 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 768670002079 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768670002080 FeS/SAM binding site; other site 768670002081 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 768670002082 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 768670002083 substrate binding pocket [chemical binding]; other site 768670002084 chain length determination region; other site 768670002085 substrate-Mg2+ binding site; other site 768670002086 catalytic residues [active] 768670002087 aspartate-rich region 1; other site 768670002088 active site lid residues [active] 768670002089 aspartate-rich region 2; other site 768670002090 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 768670002091 homotrimer interaction site [polypeptide binding]; other site 768670002092 putative active site [active] 768670002093 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 768670002094 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 768670002095 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 768670002096 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 768670002097 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 768670002098 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 768670002099 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 768670002100 putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK05641 768670002101 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 768670002102 carboxyltransferase (CT) interaction site; other site 768670002103 biotinylation site [posttranslational modification]; other site 768670002104 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 768670002105 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 768670002106 active site 768670002107 substrate binding site [chemical binding]; other site 768670002108 coenzyme B12 binding site [chemical binding]; other site 768670002109 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 768670002110 B12 binding site [chemical binding]; other site 768670002111 cobalt ligand [ion binding]; other site 768670002112 membrane ATPase/protein kinase; Provisional; Region: PRK09435 768670002113 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 768670002114 Walker A; other site 768670002115 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 768670002116 G4 box; other site 768670002117 G5 box; other site 768670002118 Adenosylhomocysteinase; Provisional; Region: PTZ00075 768670002119 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 768670002120 homotetramer interface [polypeptide binding]; other site 768670002121 ligand binding site [chemical binding]; other site 768670002122 catalytic site [active] 768670002123 NAD binding site [chemical binding]; other site 768670002124 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768670002125 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768670002126 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 768670002127 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 768670002128 HlyD family secretion protein; Region: HlyD_3; pfam13437 768670002129 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 768670002130 Protein export membrane protein; Region: SecD_SecF; cl14618 768670002131 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 768670002132 HsdM N-terminal domain; Region: HsdM_N; pfam12161 768670002133 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 768670002134 Methyltransferase domain; Region: Methyltransf_26; pfam13659 768670002135 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 768670002136 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 768670002137 Divergent AAA domain; Region: AAA_4; pfam04326 768670002138 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 768670002139 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 768670002140 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 768670002141 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 768670002142 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 768670002143 four helix bundle protein; Region: TIGR02436 768670002144 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 768670002145 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 768670002146 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768670002147 ATP binding site [chemical binding]; other site 768670002148 putative Mg++ binding site [ion binding]; other site 768670002149 helicase superfamily c-terminal domain; Region: HELICc; smart00490 768670002150 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 768670002151 Tsp45I type II restriction enzyme; Region: Tsp45I; pfam06300 768670002152 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 768670002153 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 768670002154 active site 768670002155 dimerization interface [polypeptide binding]; other site 768670002156 ribonuclease PH; Reviewed; Region: rph; PRK00173 768670002157 Ribonuclease PH; Region: RNase_PH_bact; cd11362 768670002158 hexamer interface [polypeptide binding]; other site 768670002159 active site 768670002160 ferredoxin; Provisional; Region: PRK08764 768670002161 Putative Fe-S cluster; Region: FeS; cl17515 768670002162 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 768670002163 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 768670002164 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 768670002165 4Fe-4S binding domain; Region: Fer4; pfam00037 768670002166 electron transport complex, RnfABCDGE type, A subunit; Region: rnfA; TIGR01943 768670002167 electron transport complex RsxE subunit; Provisional; Region: PRK12405 768670002168 FMN-binding domain; Region: FMN_bind; cl01081 768670002169 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116 768670002170 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 768670002171 SLBB domain; Region: SLBB; pfam10531 768670002172 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 768670002173 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 768670002174 catalytic motif [active] 768670002175 Zn binding site [ion binding]; other site 768670002176 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 768670002177 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 768670002178 dimer interface [polypeptide binding]; other site 768670002179 active site 768670002180 glycine-pyridoxal phosphate binding site [chemical binding]; other site 768670002181 folate binding site [chemical binding]; other site 768670002182 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 768670002183 B12-binding domain/radical SAM domain protein, MJ_1487 family; Region: B12_SAM_MJ_1487; TIGR04013 768670002184 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 768670002185 B12 binding site [chemical binding]; other site 768670002186 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768670002187 FeS/SAM binding site; other site 768670002188 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 768670002189 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 768670002190 dimer interface [polypeptide binding]; other site 768670002191 active site residues [active] 768670002192 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 768670002193 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768670002194 S-adenosylmethionine binding site [chemical binding]; other site 768670002195 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 768670002196 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 768670002197 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 768670002198 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 768670002199 DNA binding site [nucleotide binding] 768670002200 active site 768670002201 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 768670002202 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 768670002203 ATP binding site [chemical binding]; other site 768670002204 active site 768670002205 substrate binding site [chemical binding]; other site 768670002206 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 768670002207 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768670002208 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 768670002209 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 768670002210 active site residue [active] 768670002211 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 768670002212 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 768670002213 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 768670002214 FeS/SAM binding site; other site 768670002215 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 768670002216 [Protein-PII] uridylyltransferase; Region: UTase_glnD; TIGR01693 768670002217 metal binding triad; other site 768670002218 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 768670002219 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 768670002220 Zn2+ binding site [ion binding]; other site 768670002221 Mg2+ binding site [ion binding]; other site 768670002222 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 768670002223 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 768670002224 Stringent starvation protein B; Region: SspB; cl01120 768670002225 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 768670002226 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 768670002227 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 768670002228 Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731 768670002229 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768670002230 FeS/SAM binding site; other site 768670002231 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 768670002232 P-loop containing region of AAA domain; Region: AAA_29; cl17516 768670002233 Transcriptional regulator; Region: Rrf2; cl17282 768670002234 Rrf2 family protein; Region: rrf2_super; TIGR00738 768670002235 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665 768670002236 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 768670002237 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 768670002238 active site 768670002239 dimer interface [polypeptide binding]; other site 768670002240 effector binding site; other site 768670002241 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 768670002242 TSCPD domain; Region: TSCPD; pfam12637 768670002243 DsrE/DsrF-like family; Region: DrsE; pfam02635 768670002244 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 768670002245 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 768670002246 serine O-acetyltransferase; Region: cysE; TIGR01172 768670002247 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 768670002248 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 768670002249 trimer interface [polypeptide binding]; other site 768670002250 active site 768670002251 substrate binding site [chemical binding]; other site 768670002252 CoA binding site [chemical binding]; other site 768670002253 Transcriptional regulator; Region: Rrf2; cl17282 768670002254 Rrf2 family protein; Region: rrf2_super; TIGR00738 768670002255 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 768670002256 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 768670002257 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768670002258 catalytic residue [active] 768670002259 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 768670002260 endonuclease III; Region: ENDO3c; smart00478 768670002261 minor groove reading motif; other site 768670002262 helix-hairpin-helix signature motif; other site 768670002263 substrate binding pocket [chemical binding]; other site 768670002264 active site 768670002265 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 768670002266 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768670002267 putative DNA binding site [nucleotide binding]; other site 768670002268 putative Zn2+ binding site [ion binding]; other site 768670002269 AsnC family; Region: AsnC_trans_reg; pfam01037 768670002270 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 768670002271 active site 768670002272 Isochorismatase family; Region: Isochorismatase; pfam00857 768670002273 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 768670002274 catalytic triad [active] 768670002275 conserved cis-peptide bond; other site 768670002276 Rubrerythrin [Energy production and conversion]; Region: COG1592 768670002277 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 768670002278 binuclear metal center [ion binding]; other site 768670002279 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 768670002280 iron binding site [ion binding]; other site 768670002281 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 768670002282 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 768670002283 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 768670002284 catalytic loop [active] 768670002285 iron binding site [ion binding]; other site 768670002286 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 768670002287 FAD binding pocket [chemical binding]; other site 768670002288 FAD binding motif [chemical binding]; other site 768670002289 phosphate binding motif [ion binding]; other site 768670002290 beta-alpha-beta structure motif; other site 768670002291 NAD binding pocket [chemical binding]; other site 768670002292 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 768670002293 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 768670002294 FMN-binding domain; Region: FMN_bind; cl01081 768670002295 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 768670002296 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 768670002297 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 768670002298 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 768670002299 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 768670002300 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768670002301 binding surface 768670002302 TPR motif; other site 768670002303 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 768670002304 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 768670002305 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 768670002306 Uncharacterized conserved protein [Function unknown]; Region: COG1565 768670002307 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 768670002308 active site 768670002309 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 768670002310 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768670002311 active site 768670002312 phosphorylation site [posttranslational modification] 768670002313 intermolecular recognition site; other site 768670002314 dimerization interface [polypeptide binding]; other site 768670002315 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768670002316 Walker A motif; other site 768670002317 ATP binding site [chemical binding]; other site 768670002318 Walker B motif; other site 768670002319 arginine finger; other site 768670002320 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 768670002321 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768670002322 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768670002323 dimer interface [polypeptide binding]; other site 768670002324 phosphorylation site [posttranslational modification] 768670002325 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768670002326 ATP binding site [chemical binding]; other site 768670002327 Mg2+ binding site [ion binding]; other site 768670002328 G-X-G motif; other site 768670002329 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 768670002330 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 768670002331 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 768670002332 4Fe-4S binding domain; Region: Fer4; pfam00037 768670002333 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 768670002334 The MopB_Tetrathionate-Ra CD contains tetrathionate reductase, subunit A, (TtrA) and other related proteins. The Salmonella enterica tetrathionate reductase catalyses the reduction of trithionate but not sulfur or thiosulfate. Members of this CD belong...; Region: MopB_Tetrathionate-Ra; cd02758 768670002335 putative molybdopterin cofactor binding site [chemical binding]; other site 768670002336 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780 768670002337 putative molybdopterin cofactor binding site; other site 768670002338 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 768670002339 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 768670002340 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 768670002341 dimer interface [polypeptide binding]; other site 768670002342 FMN binding site [chemical binding]; other site 768670002343 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 768670002344 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 768670002345 active site 768670002346 (T/H)XGH motif; other site 768670002347 Response regulator receiver domain; Region: Response_reg; pfam00072 768670002348 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768670002349 active site 768670002350 phosphorylation site [posttranslational modification] 768670002351 intermolecular recognition site; other site 768670002352 dimerization interface [polypeptide binding]; other site 768670002353 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 768670002354 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768670002355 active site 768670002356 phosphorylation site [posttranslational modification] 768670002357 intermolecular recognition site; other site 768670002358 dimerization interface [polypeptide binding]; other site 768670002359 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 768670002360 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768670002361 dimerization interface [polypeptide binding]; other site 768670002362 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768670002363 dimerization interface [polypeptide binding]; other site 768670002364 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 768670002365 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 768670002366 dimer interface [polypeptide binding]; other site 768670002367 putative CheW interface [polypeptide binding]; other site 768670002368 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 768670002369 putative binding surface; other site 768670002370 active site 768670002371 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768670002372 ATP binding site [chemical binding]; other site 768670002373 Mg2+ binding site [ion binding]; other site 768670002374 G-X-G motif; other site 768670002375 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 768670002376 Response regulator receiver domain; Region: Response_reg; pfam00072 768670002377 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768670002378 active site 768670002379 phosphorylation site [posttranslational modification] 768670002380 intermolecular recognition site; other site 768670002381 dimerization interface [polypeptide binding]; other site 768670002382 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 768670002383 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 768670002384 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768670002385 active site 768670002386 phosphorylation site [posttranslational modification] 768670002387 intermolecular recognition site; other site 768670002388 dimerization interface [polypeptide binding]; other site 768670002389 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 768670002390 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 768670002391 dimerization interface [polypeptide binding]; other site 768670002392 putative ATP binding site [chemical binding]; other site 768670002393 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 768670002394 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 768670002395 active site 768670002396 substrate binding site [chemical binding]; other site 768670002397 cosubstrate binding site; other site 768670002398 catalytic site [active] 768670002399 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 768670002400 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 768670002401 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 768670002402 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 768670002403 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 768670002404 dimer interface [polypeptide binding]; other site 768670002405 decamer (pentamer of dimers) interface [polypeptide binding]; other site 768670002406 catalytic triad [active] 768670002407 peroxidatic and resolving cysteines [active] 768670002408 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 768670002409 Ferritin-like domain; Region: Ferritin; pfam00210 768670002410 ferroxidase diiron center [ion binding]; other site 768670002411 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 768670002412 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 768670002413 Zn2+ binding site [ion binding]; other site 768670002414 Mg2+ binding site [ion binding]; other site 768670002415 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 768670002416 synthetase active site [active] 768670002417 NTP binding site [chemical binding]; other site 768670002418 metal binding site [ion binding]; metal-binding site 768670002419 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 768670002420 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 768670002421 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 768670002422 DHH family; Region: DHH; pfam01368 768670002423 DHHA1 domain; Region: DHHA1; pfam02272 768670002424 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 768670002425 active site residue [active] 768670002426 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 768670002427 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 768670002428 active site residue [active] 768670002429 excinuclease ABC subunit B; Provisional; Region: PRK05298 768670002430 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768670002431 ATP binding site [chemical binding]; other site 768670002432 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768670002433 nucleotide binding region [chemical binding]; other site 768670002434 ATP-binding site [chemical binding]; other site 768670002435 Ultra-violet resistance protein B; Region: UvrB; pfam12344 768670002436 UvrB/uvrC motif; Region: UVR; pfam02151 768670002437 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 768670002438 Transglycosylase; Region: Transgly; pfam00912 768670002439 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 768670002440 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768670002441 phosphorylation site [posttranslational modification] 768670002442 dimer interface [polypeptide binding]; other site 768670002443 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768670002444 ATP binding site [chemical binding]; other site 768670002445 Mg2+ binding site [ion binding]; other site 768670002446 G-X-G motif; other site 768670002447 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 768670002448 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768670002449 active site 768670002450 phosphorylation site [posttranslational modification] 768670002451 intermolecular recognition site; other site 768670002452 dimerization interface [polypeptide binding]; other site 768670002453 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768670002454 Walker A motif; other site 768670002455 ATP binding site [chemical binding]; other site 768670002456 Walker B motif; other site 768670002457 arginine finger; other site 768670002458 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 768670002459 ribonuclease R; Region: RNase_R; TIGR02063 768670002460 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 768670002461 RNB domain; Region: RNB; pfam00773 768670002462 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 768670002463 RNA binding site [nucleotide binding]; other site 768670002464 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 768670002465 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 768670002466 active site 768670002467 catalytic residues [active] 768670002468 metal binding site [ion binding]; metal-binding site 768670002469 Radical SAM superfamily; Region: Radical_SAM; pfam04055 768670002470 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768670002471 FeS/SAM binding site; other site 768670002472 Nif-specific regulatory protein; Region: nifA; TIGR01817 768670002473 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 768670002474 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768670002475 Walker A motif; other site 768670002476 ATP binding site [chemical binding]; other site 768670002477 Walker B motif; other site 768670002478 arginine finger; other site 768670002479 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 768670002480 NifZ domain; Region: NifZ; pfam04319 768670002481 ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936 768670002482 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 768670002483 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 768670002484 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 768670002485 nitrogenase molybdenum-cofactor biosynthesis protein NifN; Provisional; Region: PRK14476 768670002486 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 768670002487 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 768670002488 Protein of unknown function, DUF269; Region: DUF269; cl03973 768670002489 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 768670002490 Dinitrogenase reductase ADP-ribosyltransferase (DRAT); Region: DRAT; pfam07357 768670002491 nitrogenase reductase; Reviewed; Region: nifH; PRK13234 768670002492 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 768670002493 Nucleotide-binding sites [chemical binding]; other site 768670002494 Walker A motif; other site 768670002495 Switch I region of nucleotide binding site; other site 768670002496 Fe4S4 binding sites [ion binding]; other site 768670002497 Switch II region of nucleotide binding site; other site 768670002498 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 768670002499 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 768670002500 MoFe protein alpha/beta subunit interactions; other site 768670002501 Alpha subunit P cluster binding residues; other site 768670002502 FeMoco binding residues [chemical binding]; other site 768670002503 MoFe protein alpha subunit/Fe protein contacts; other site 768670002504 MoFe protein dimer/ dimer interactions; other site 768670002505 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 768670002506 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 768670002507 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 768670002508 NifT/FixU protein; Region: NifT; pfam06988 768670002509 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 768670002510 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768670002511 Walker A/P-loop; other site 768670002512 ATP binding site [chemical binding]; other site 768670002513 Q-loop/lid; other site 768670002514 ABC transporter signature motif; other site 768670002515 Walker B; other site 768670002516 D-loop; other site 768670002517 H-loop/switch region; other site 768670002518 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 768670002519 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768670002520 putative PBP binding loops; other site 768670002521 dimer interface [polypeptide binding]; other site 768670002522 ABC-ATPase subunit interface; other site 768670002523 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 768670002524 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 768670002525 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 768670002526 LexA repressor; Validated; Region: PRK00215 768670002527 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 768670002528 Catalytic site [active] 768670002529 Pleckstrin homology-like domain; Region: PH-like; cl17171 768670002530 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 768670002531 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 768670002532 active site 768670002533 DNA binding site [nucleotide binding] 768670002534 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 768670002535 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 768670002536 Walker A/P-loop; other site 768670002537 ATP binding site [chemical binding]; other site 768670002538 Q-loop/lid; other site 768670002539 ABC transporter signature motif; other site 768670002540 Walker B; other site 768670002541 D-loop; other site 768670002542 H-loop/switch region; other site 768670002543 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 768670002544 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 768670002545 Walker A/P-loop; other site 768670002546 ATP binding site [chemical binding]; other site 768670002547 Q-loop/lid; other site 768670002548 ABC transporter signature motif; other site 768670002549 Walker B; other site 768670002550 D-loop; other site 768670002551 H-loop/switch region; other site 768670002552 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 768670002553 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 768670002554 TM-ABC transporter signature motif; other site 768670002555 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768670002556 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 768670002557 TM-ABC transporter signature motif; other site 768670002558 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 768670002559 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 768670002560 putative ligand binding site [chemical binding]; other site 768670002561 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 768670002562 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768670002563 non-specific DNA binding site [nucleotide binding]; other site 768670002564 salt bridge; other site 768670002565 sequence-specific DNA binding site [nucleotide binding]; other site 768670002566 Cupin domain; Region: Cupin_2; pfam07883 768670002567 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 768670002568 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 768670002569 Competence protein; Region: Competence; pfam03772 768670002570 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 768670002571 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 768670002572 HflX GTPase family; Region: HflX; cd01878 768670002573 G1 box; other site 768670002574 GTP/Mg2+ binding site [chemical binding]; other site 768670002575 Switch I region; other site 768670002576 G2 box; other site 768670002577 G3 box; other site 768670002578 Switch II region; other site 768670002579 G4 box; other site 768670002580 G5 box; other site 768670002581 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 768670002582 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 768670002583 dimer interface [polypeptide binding]; other site 768670002584 putative functional site; other site 768670002585 putative MPT binding site; other site 768670002586 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 768670002587 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 768670002588 active site 768670002589 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 768670002590 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 768670002591 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 768670002592 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 768670002593 NAD(P) binding site [chemical binding]; other site 768670002594 homodimer interface [polypeptide binding]; other site 768670002595 substrate binding site [chemical binding]; other site 768670002596 active site 768670002597 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 768670002598 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 768670002599 inhibitor-cofactor binding pocket; inhibition site 768670002600 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768670002601 catalytic residue [active] 768670002602 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 768670002603 ligand binding site; other site 768670002604 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 768670002605 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 768670002606 putative active site [active] 768670002607 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 768670002608 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 768670002609 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 768670002610 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 768670002611 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 768670002612 AMP binding site [chemical binding]; other site 768670002613 active site 768670002614 acyl-activating enzyme (AAE) consensus motif; other site 768670002615 CoA binding site [chemical binding]; other site 768670002616 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 768670002617 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 768670002618 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 768670002619 Phosphopantetheine attachment site; Region: PP-binding; cl09936 768670002620 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 768670002621 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 768670002622 metal binding site [ion binding]; metal-binding site 768670002623 M28 Zn-Peptidases; Region: M28_like_3; cd05644 768670002624 Domain of unknown function (DUF2172); Region: DUF2172; pfam09940 768670002625 active site 768670002626 metal binding site [ion binding]; metal-binding site 768670002627 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 768670002628 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 768670002629 pseudaminic acid synthase; Region: PseI; TIGR03586 768670002630 NeuB family; Region: NeuB; pfam03102 768670002631 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 768670002632 NeuB binding interface [polypeptide binding]; other site 768670002633 putative substrate binding site [chemical binding]; other site 768670002634 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604 768670002635 MULE transposase domain; Region: MULE; pfam10551 768670002636 Transposase; Region: DDE_Tnp_ISL3; pfam01610 768670002637 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG1817 768670002638 Acylphosphatase; Region: Acylphosphatase; pfam00708 768670002639 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 768670002640 HypF finger; Region: zf-HYPF; pfam07503 768670002641 HypF finger; Region: zf-HYPF; pfam07503 768670002642 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 768670002643 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 768670002644 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768670002645 S-adenosylmethionine binding site [chemical binding]; other site 768670002646 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 768670002647 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768670002648 Walker A/P-loop; other site 768670002649 ATP binding site [chemical binding]; other site 768670002650 Q-loop/lid; other site 768670002651 ABC transporter signature motif; other site 768670002652 Walker B; other site 768670002653 D-loop; other site 768670002654 H-loop/switch region; other site 768670002655 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 768670002656 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 768670002657 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 768670002658 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 768670002659 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 768670002660 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 768670002661 Malic enzyme, N-terminal domain; Region: malic; pfam00390 768670002662 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 768670002663 NAD(P) binding pocket [chemical binding]; other site 768670002664 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 768670002665 putative active site [active] 768670002666 putative CoA binding site [chemical binding]; other site 768670002667 nudix motif; other site 768670002668 metal binding site [ion binding]; metal-binding site 768670002669 Uncharacterized conserved protein [Function unknown]; Region: COG3937 768670002670 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 768670002671 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 768670002672 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 768670002673 ligand binding site [chemical binding]; other site 768670002674 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 768670002675 flagellar motor stator protein MotA; Region: MotA1; TIGR03818 768670002676 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 768670002677 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 768670002678 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 768670002679 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 768670002680 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 768670002681 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 768670002682 acetylornithine aminotransferase; Provisional; Region: PRK02627 768670002683 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 768670002684 inhibitor-cofactor binding pocket; inhibition site 768670002685 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768670002686 catalytic residue [active] 768670002687 ornithine carbamoyltransferase; Provisional; Region: PRK00779 768670002688 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 768670002689 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 768670002690 argininosuccinate synthase; Provisional; Region: PRK13820 768670002691 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 768670002692 ANP binding site [chemical binding]; other site 768670002693 Substrate Binding Site II [chemical binding]; other site 768670002694 Substrate Binding Site I [chemical binding]; other site 768670002695 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 768670002696 dimer interface [polypeptide binding]; other site 768670002697 motif 1; other site 768670002698 active site 768670002699 motif 2; other site 768670002700 motif 3; other site 768670002701 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 768670002702 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 768670002703 conserved cys residue [active] 768670002704 protoporphyrinogen oxidase; Region: proto_IX_ox; TIGR00562 768670002705 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 768670002706 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 768670002707 homotrimer interaction site [polypeptide binding]; other site 768670002708 zinc binding site [ion binding]; other site 768670002709 CDP-binding sites; other site 768670002710 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 768670002711 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768670002712 motif II; other site 768670002713 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 768670002714 putative deacylase active site [active] 768670002715 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 768670002716 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768670002717 S-adenosylmethionine binding site [chemical binding]; other site 768670002718 primosome assembly protein PriA; Validated; Region: PRK05580 768670002719 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768670002720 ATP binding site [chemical binding]; other site 768670002721 putative Mg++ binding site [ion binding]; other site 768670002722 helicase superfamily c-terminal domain; Region: HELICc; smart00490 768670002723 polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708 768670002724 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 768670002725 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 768670002726 Thiamine monophosphate kinase [Coenzyme metabolism]; Region: ThiL; COG0611 768670002727 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 768670002728 ATP binding site [chemical binding]; other site 768670002729 dimerization interface [polypeptide binding]; other site 768670002730 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 768670002731 thiamine phosphate binding site [chemical binding]; other site 768670002732 active site 768670002733 pyrophosphate binding site [ion binding]; other site 768670002734 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 768670002735 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 768670002736 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 768670002737 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 768670002738 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 768670002739 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 768670002740 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565 768670002741 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 768670002742 phosphate binding site [ion binding]; other site 768670002743 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 768670002744 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 768670002745 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768670002746 PAS domain; Region: PAS_9; pfam13426 768670002747 putative active site [active] 768670002748 heme pocket [chemical binding]; other site 768670002749 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 768670002750 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768670002751 metal binding site [ion binding]; metal-binding site 768670002752 active site 768670002753 I-site; other site 768670002754 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 768670002755 Cache domain; Region: Cache_2; cl07034 768670002756 Cache domain; Region: Cache_1; pfam02743 768670002757 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768670002758 dimerization interface [polypeptide binding]; other site 768670002759 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 768670002760 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 768670002761 dimer interface [polypeptide binding]; other site 768670002762 putative CheW interface [polypeptide binding]; other site 768670002763 propionate/acetate kinase; Provisional; Region: PRK12379 768670002764 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 768670002765 nucleotide binding site [chemical binding]; other site 768670002766 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 768670002767 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 768670002768 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 768670002769 ligand binding site [chemical binding]; other site 768670002770 flexible hinge region; other site 768670002771 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 768670002772 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 768670002773 metal binding triad; other site 768670002774 Protein of unknown function, DUF485; Region: DUF485; pfam04341 768670002775 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 768670002776 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 768670002777 Na binding site [ion binding]; other site 768670002778 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 768670002779 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 768670002780 active site 768670002781 catalytic site [active] 768670002782 substrate binding site [chemical binding]; other site 768670002783 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 768670002784 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768670002785 S-adenosylmethionine binding site [chemical binding]; other site 768670002786 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 768670002787 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 768670002788 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 768670002789 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 768670002790 molybdopterin cofactor binding site; other site 768670002791 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 768670002792 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775 768670002793 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 768670002794 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 768670002795 N-acetyl-D-glucosamine binding site [chemical binding]; other site 768670002796 catalytic residue [active] 768670002797 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 768670002798 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 768670002799 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 768670002800 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 768670002801 butyrate kinase; Provisional; Region: PRK03011 768670002802 Cupin domain; Region: Cupin_2; pfam07883 768670002803 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 768670002804 Metal binding protein ZntC. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: ZntC; cd01018 768670002805 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 768670002806 putative metal binding residues [ion binding]; other site 768670002807 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 768670002808 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 768670002809 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 768670002810 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768670002811 ABC-ATPase subunit interface; other site 768670002812 dimer interface [polypeptide binding]; other site 768670002813 putative PBP binding regions; other site 768670002814 Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735 768670002815 metal binding site 2 [ion binding]; metal-binding site 768670002816 putative DNA binding helix; other site 768670002817 metal binding site 1 [ion binding]; metal-binding site 768670002818 dimer interface [polypeptide binding]; other site 768670002819 structural Zn2+ binding site [ion binding]; other site 768670002820 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 768670002821 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768670002822 motif II; other site 768670002823 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 768670002824 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 768670002825 active site 768670002826 putative substrate binding pocket [chemical binding]; other site 768670002827 Predicted permeases [General function prediction only]; Region: COG0679 768670002828 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 768670002829 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 768670002830 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 768670002831 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768670002832 active site 768670002833 phosphorylation site [posttranslational modification] 768670002834 intermolecular recognition site; other site 768670002835 dimerization interface [polypeptide binding]; other site 768670002836 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 768670002837 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768670002838 binding surface 768670002839 TPR motif; other site 768670002840 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 768670002841 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 768670002842 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 768670002843 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 768670002844 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 768670002845 FlaG protein; Region: FlaG; pfam03646 768670002846 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 768670002847 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 768670002848 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 768670002849 dimer interface [polypeptide binding]; other site 768670002850 putative CheW interface [polypeptide binding]; other site 768670002851 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 768670002852 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 768670002853 minor groove reading motif; other site 768670002854 helix-hairpin-helix signature motif; other site 768670002855 substrate binding pocket [chemical binding]; other site 768670002856 active site 768670002857 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768670002858 dimer interface [polypeptide binding]; other site 768670002859 phosphorylation site [posttranslational modification] 768670002860 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768670002861 ATP binding site [chemical binding]; other site 768670002862 Mg2+ binding site [ion binding]; other site 768670002863 G-X-G motif; other site 768670002864 Response regulator receiver domain; Region: Response_reg; pfam00072 768670002865 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768670002866 active site 768670002867 phosphorylation site [posttranslational modification] 768670002868 intermolecular recognition site; other site 768670002869 dimerization interface [polypeptide binding]; other site 768670002870 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 768670002871 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768670002872 active site 768670002873 phosphorylation site [posttranslational modification] 768670002874 intermolecular recognition site; other site 768670002875 dimerization interface [polypeptide binding]; other site 768670002876 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 768670002877 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768670002878 putative active site [active] 768670002879 heme pocket [chemical binding]; other site 768670002880 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768670002881 dimer interface [polypeptide binding]; other site 768670002882 phosphorylation site [posttranslational modification] 768670002883 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768670002884 ATP binding site [chemical binding]; other site 768670002885 Mg2+ binding site [ion binding]; other site 768670002886 G-X-G motif; other site 768670002887 Response regulator receiver domain; Region: Response_reg; pfam00072 768670002888 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768670002889 active site 768670002890 phosphorylation site [posttranslational modification] 768670002891 intermolecular recognition site; other site 768670002892 dimerization interface [polypeptide binding]; other site 768670002893 Response regulator receiver domain; Region: Response_reg; pfam00072 768670002894 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768670002895 active site 768670002896 phosphorylation site [posttranslational modification] 768670002897 intermolecular recognition site; other site 768670002898 dimerization interface [polypeptide binding]; other site 768670002899 HDOD domain; Region: HDOD; pfam08668 768670002900 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 768670002901 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768670002902 active site 768670002903 phosphorylation site [posttranslational modification] 768670002904 intermolecular recognition site; other site 768670002905 dimerization interface [polypeptide binding]; other site 768670002906 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 768670002907 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768670002908 active site 768670002909 phosphorylation site [posttranslational modification] 768670002910 intermolecular recognition site; other site 768670002911 dimerization interface [polypeptide binding]; other site 768670002912 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768670002913 dimer interface [polypeptide binding]; other site 768670002914 phosphorylation site [posttranslational modification] 768670002915 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768670002916 ATP binding site [chemical binding]; other site 768670002917 Mg2+ binding site [ion binding]; other site 768670002918 G-X-G motif; other site 768670002919 Response regulator receiver domain; Region: Response_reg; pfam00072 768670002920 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768670002921 active site 768670002922 phosphorylation site [posttranslational modification] 768670002923 intermolecular recognition site; other site 768670002924 dimerization interface [polypeptide binding]; other site 768670002925 PAS domain; Region: PAS_9; pfam13426 768670002926 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768670002927 putative active site [active] 768670002928 heme pocket [chemical binding]; other site 768670002929 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768670002930 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768670002931 ATP binding site [chemical binding]; other site 768670002932 Mg2+ binding site [ion binding]; other site 768670002933 G-X-G motif; other site 768670002934 Response regulator receiver domain; Region: Response_reg; pfam00072 768670002935 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768670002936 active site 768670002937 phosphorylation site [posttranslational modification] 768670002938 intermolecular recognition site; other site 768670002939 dimerization interface [polypeptide binding]; other site 768670002940 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768670002941 PAS domain; Region: PAS_9; pfam13426 768670002942 putative active site [active] 768670002943 heme pocket [chemical binding]; other site 768670002944 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 768670002945 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768670002946 metal binding site [ion binding]; metal-binding site 768670002947 active site 768670002948 I-site; other site 768670002949 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 768670002950 Uncharacterized conserved protein [Function unknown]; Region: COG1633 768670002951 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 768670002952 diiron binding motif [ion binding]; other site 768670002953 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 768670002954 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768670002955 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768670002956 homodimer interface [polypeptide binding]; other site 768670002957 catalytic residue [active] 768670002958 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 768670002959 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 768670002960 CPxP motif; other site 768670002961 DsrE/DsrF-like family; Region: DrsE; pfam02635 768670002962 Selenophosphate synthase [Amino acid transport and metabolism]; Region: SelD; COG0709 768670002963 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 768670002964 dimerization interface [polypeptide binding]; other site 768670002965 putative ATP binding site [chemical binding]; other site 768670002966 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 768670002967 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768670002968 non-specific DNA binding site [nucleotide binding]; other site 768670002969 salt bridge; other site 768670002970 sequence-specific DNA binding site [nucleotide binding]; other site 768670002971 Cupin domain; Region: Cupin_2; pfam07883 768670002972 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 768670002973 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 768670002974 Protein of unknown function (DUF3373); Region: DUF3373; pfam11853 768670002975 NosL; Region: NosL; cl01769 768670002976 NosL; Region: NosL; cl01769 768670002977 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 768670002978 FtsX-like permease family; Region: FtsX; pfam02687 768670002979 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 768670002980 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 768670002981 Walker A/P-loop; other site 768670002982 ATP binding site [chemical binding]; other site 768670002983 Q-loop/lid; other site 768670002984 ABC transporter signature motif; other site 768670002985 Walker B; other site 768670002986 D-loop; other site 768670002987 H-loop/switch region; other site 768670002988 Rrf2 family protein; Region: rrf2_super; TIGR00738 768670002989 Transcriptional regulator; Region: Rrf2; cl17282 768670002990 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 768670002991 Low-spin heme binding site [chemical binding]; other site 768670002992 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 768670002993 D-pathway; other site 768670002994 Putative water exit pathway; other site 768670002995 Binuclear center (active site) [active] 768670002996 K-pathway; other site 768670002997 Putative proton exit pathway; other site 768670002998 putative bifunctional cbb3-type cytochrome c oxidase subunit II/cytochrome c; Provisional; Region: PRK14486 768670002999 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 768670003000 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 768670003001 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 768670003002 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 768670003003 4Fe-4S binding domain; Region: Fer4_5; pfam12801 768670003004 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 768670003005 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 768670003006 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 768670003007 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 768670003008 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 768670003009 metal-binding site [ion binding] 768670003010 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 768670003011 Family description; Region: DsbD_2; pfam13386 768670003012 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 768670003013 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 768670003014 motif 1; other site 768670003015 active site 768670003016 motif 2; other site 768670003017 motif 3; other site 768670003018 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 768670003019 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 768670003020 DHHA1 domain; Region: DHHA1; pfam02272 768670003021 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 768670003022 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 768670003023 active site 768670003024 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 768670003025 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 768670003026 active site 768670003027 substrate-binding site [chemical binding]; other site 768670003028 metal-binding site [ion binding] 768670003029 ATP binding site [chemical binding]; other site 768670003030 ketol-acid reductoisomerase; Provisional; Region: PRK05479 768670003031 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 768670003032 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 768670003033 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 768670003034 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 768670003035 putative valine binding site [chemical binding]; other site 768670003036 dimer interface [polypeptide binding]; other site 768670003037 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 768670003038 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048 768670003039 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 768670003040 PYR/PP interface [polypeptide binding]; other site 768670003041 dimer interface [polypeptide binding]; other site 768670003042 TPP binding site [chemical binding]; other site 768670003043 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 768670003044 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 768670003045 TPP-binding site [chemical binding]; other site 768670003046 dimer interface [polypeptide binding]; other site 768670003047 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 768670003048 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768670003049 FeS/SAM binding site; other site 768670003050 Helix-hairpin-helix DNA-binding motif class 1; Region: HhH1; smart00278 768670003051 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 768670003052 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 768670003053 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 768670003054 FtsX-like permease family; Region: FtsX; pfam02687 768670003055 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 768670003056 FtsX-like permease family; Region: FtsX; pfam02687 768670003057 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 768670003058 TrkA-N domain; Region: TrkA_N; pfam02254 768670003059 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 768670003060 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 768670003061 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 768670003062 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 768670003063 active site 768670003064 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 768670003065 Membrane protein of unknown function; Region: DUF360; pfam04020 768670003066 Domain of unknown function (DUF1820); Region: DUF1820; cl11545 768670003067 Predicted permeases [General function prediction only]; Region: COG0795 768670003068 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 768670003069 Predicted permeases [General function prediction only]; Region: COG0795 768670003070 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 768670003071 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 768670003072 Ligand Binding Site [chemical binding]; other site 768670003073 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 768670003074 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 768670003075 active site residue [active] 768670003076 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 768670003077 active site residue [active] 768670003078 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 768670003079 active site residue [active] 768670003080 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 768670003081 structural tetrad; other site 768670003082 FOG: WD40 repeat [General function prediction only]; Region: COG2319 768670003083 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 768670003084 structural tetrad; other site 768670003085 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 768670003086 structural tetrad; other site 768670003087 Caspase domain; Region: Peptidase_C14; pfam00656 768670003088 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172 768670003089 serpin-like protein; Provisional; Region: PHA02660 768670003090 reactive center loop; other site 768670003091 Integral membrane protein (DUF2244); Region: DUF2244; cl02302 768670003092 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 768670003093 FOG: WD40 repeat [General function prediction only]; Region: COG2319 768670003094 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 768670003095 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 768670003096 structural tetrad; other site 768670003097 FOG: WD40 repeat [General function prediction only]; Region: COG2319 768670003098 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 768670003099 structural tetrad; other site 768670003100 Caspase domain; Region: Peptidase_C14; pfam00656 768670003101 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172 768670003102 serpin-like protein; Provisional; Region: PHA02660 768670003103 reactive center loop; other site 768670003104 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 768670003105 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 768670003106 Caspase domain; Region: Peptidase_C14; pfam00656 768670003107 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 768670003108 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 768670003109 structural tetrad; other site 768670003110 FOG: WD40 repeat [General function prediction only]; Region: COG2319 768670003111 FOG: WD40 repeat [General function prediction only]; Region: COG2319 768670003112 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 768670003113 Caspase domain; Region: Peptidase_C14; pfam00656 768670003114 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 768670003115 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768670003116 dimer interface [polypeptide binding]; other site 768670003117 conserved gate region; other site 768670003118 putative PBP binding loops; other site 768670003119 ABC-ATPase subunit interface; other site 768670003120 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 768670003121 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768670003122 dimer interface [polypeptide binding]; other site 768670003123 conserved gate region; other site 768670003124 putative PBP binding loops; other site 768670003125 ABC-ATPase subunit interface; other site 768670003126 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 768670003127 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 768670003128 peptide binding site [polypeptide binding]; other site 768670003129 Preprotein translocase SecG subunit; Region: SecG; cl09123 768670003130 FOG: CBS domain [General function prediction only]; Region: COG0517 768670003131 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 768670003132 acetate--CoA ligase; Region: Ac_CoA_lig_AcsA; TIGR02188 768670003133 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 768670003134 acyl-activating enzyme (AAE) consensus motif; other site 768670003135 AMP binding site [chemical binding]; other site 768670003136 active site 768670003137 CoA binding site [chemical binding]; other site 768670003138 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 768670003139 homoserine dehydrogenase; Provisional; Region: PRK06349 768670003140 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 768670003141 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 768670003142 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 768670003143 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200 768670003144 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294 768670003145 aspartate kinase; Reviewed; Region: PRK06635 768670003146 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 768670003147 putative nucleotide binding site [chemical binding]; other site 768670003148 putative catalytic residues [active] 768670003149 putative Mg ion binding site [ion binding]; other site 768670003150 putative aspartate binding site [chemical binding]; other site 768670003151 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 768670003152 putative allosteric regulatory site; other site 768670003153 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 768670003154 putative allosteric regulatory residue; other site 768670003155 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 768670003156 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 768670003157 active site 768670003158 catalytic residues [active] 768670003159 metal binding site [ion binding]; metal-binding site 768670003160 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 768670003161 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 768670003162 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 768670003163 dimer interface [polypeptide binding]; other site 768670003164 anticodon binding site; other site 768670003165 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 768670003166 homodimer interface [polypeptide binding]; other site 768670003167 motif 1; other site 768670003168 active site 768670003169 motif 2; other site 768670003170 GAD domain; Region: GAD; pfam02938 768670003171 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 768670003172 motif 3; other site 768670003173 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 768670003174 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 768670003175 dimer interface [polypeptide binding]; other site 768670003176 motif 1; other site 768670003177 active site 768670003178 motif 2; other site 768670003179 motif 3; other site 768670003180 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 768670003181 anticodon binding site; other site 768670003182 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 768670003183 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 768670003184 catalytic center binding site [active] 768670003185 ATP binding site [chemical binding]; other site 768670003186 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 768670003187 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768670003188 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768670003189 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 768670003190 S-adenosylmethionine synthetase; Validated; Region: PRK05250 768670003191 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 768670003192 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 768670003193 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 768670003194 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 768670003195 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768670003196 Coenzyme A binding pocket [chemical binding]; other site 768670003197 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 768670003198 Glycoprotease family; Region: Peptidase_M22; pfam00814 768670003199 Uncharacterized conserved protein [Function unknown]; Region: COG0432 768670003200 DHH family; Region: DHH; pfam01368 768670003201 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 768670003202 G1 box; other site 768670003203 GTP/Mg2+ binding site [chemical binding]; other site 768670003204 Switch I region; other site 768670003205 G2 box; other site 768670003206 G3 box; other site 768670003207 Switch II region; other site 768670003208 G4 box; other site 768670003209 G5 box; other site 768670003210 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 768670003211 PLD-like domain; Region: PLDc_2; pfam13091 768670003212 putative active site [active] 768670003213 catalytic site [active] 768670003214 Proline dehydrogenase; Region: Pro_dh; cl03282 768670003215 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 768670003216 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 768670003217 Glutamate binding site [chemical binding]; other site 768670003218 NAD binding site [chemical binding]; other site 768670003219 catalytic residues [active] 768670003220 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 768670003221 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768670003222 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 768670003223 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 768670003224 dimer interface [polypeptide binding]; other site 768670003225 active site 768670003226 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 768670003227 catalytic residues [active] 768670003228 substrate binding site [chemical binding]; other site 768670003229 Nucleoside recognition; Region: Gate; pfam07670 768670003230 Uncharacterized membrane protein [Function unknown]; Region: SpmB; cl17667 768670003231 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 768670003232 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 768670003233 acyl-activating enzyme (AAE) consensus motif; other site 768670003234 AMP binding site [chemical binding]; other site 768670003235 active site 768670003236 CoA binding site [chemical binding]; other site 768670003237 ACT domain-containing protein [General function prediction only]; Region: COG4747 768670003238 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 768670003239 C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882 768670003240 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 768670003241 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 768670003242 putative ligand binding site [chemical binding]; other site 768670003243 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 768670003244 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 768670003245 putative ligand binding site [chemical binding]; other site 768670003246 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768670003247 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 768670003248 TM-ABC transporter signature motif; other site 768670003249 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 768670003250 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 768670003251 TM-ABC transporter signature motif; other site 768670003252 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 768670003253 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 768670003254 Walker A/P-loop; other site 768670003255 ATP binding site [chemical binding]; other site 768670003256 Q-loop/lid; other site 768670003257 ABC transporter signature motif; other site 768670003258 Walker B; other site 768670003259 D-loop; other site 768670003260 H-loop/switch region; other site 768670003261 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 768670003262 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 768670003263 Walker A/P-loop; other site 768670003264 ATP binding site [chemical binding]; other site 768670003265 Q-loop/lid; other site 768670003266 ABC transporter signature motif; other site 768670003267 Walker B; other site 768670003268 D-loop; other site 768670003269 H-loop/switch region; other site 768670003270 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 768670003271 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 768670003272 acyl-activating enzyme (AAE) consensus motif; other site 768670003273 AMP binding site [chemical binding]; other site 768670003274 active site 768670003275 CoA binding site [chemical binding]; other site 768670003276 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 768670003277 Zn2+ binding site [ion binding]; other site 768670003278 Mg2+ binding site [ion binding]; other site 768670003279 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 768670003280 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 768670003281 dimer interface [polypeptide binding]; other site 768670003282 PYR/PP interface [polypeptide binding]; other site 768670003283 TPP binding site [chemical binding]; other site 768670003284 substrate binding site [chemical binding]; other site 768670003285 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 768670003286 Domain of unknown function; Region: EKR; pfam10371 768670003287 4Fe-4S binding domain; Region: Fer4_6; pfam12837 768670003288 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 768670003289 TPP-binding site [chemical binding]; other site 768670003290 dimer interface [polypeptide binding]; other site 768670003291 dihydroorotase; Validated; Region: pyrC; PRK09357 768670003292 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 768670003293 active site 768670003294 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 768670003295 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 768670003296 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 768670003297 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 768670003298 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768670003299 active site 768670003300 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 768670003301 Coenzyme A binding pocket [chemical binding]; other site 768670003302 peptide chain release factor 2; Validated; Region: prfB; PRK00578 768670003303 This domain is found in peptide chain release factors; Region: PCRF; smart00937 768670003304 RF-1 domain; Region: RF-1; pfam00472 768670003305 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 768670003306 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 768670003307 active site 768670003308 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 768670003309 dimer interface [polypeptide binding]; other site 768670003310 substrate binding site [chemical binding]; other site 768670003311 catalytic residues [active] 768670003312 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 768670003313 Permease; Region: Permease; pfam02405 768670003314 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 768670003315 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 768670003316 Walker A/P-loop; other site 768670003317 ATP binding site [chemical binding]; other site 768670003318 Q-loop/lid; other site 768670003319 ABC transporter signature motif; other site 768670003320 Walker B; other site 768670003321 D-loop; other site 768670003322 H-loop/switch region; other site 768670003323 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 768670003324 mce related protein; Region: MCE; pfam02470 768670003325 Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475 768670003326 Phospholipid methyltransferase; Region: PEMT; cl17370 768670003327 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 768670003328 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 768670003329 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 768670003330 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 768670003331 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 768670003332 trimer interface [polypeptide binding]; other site 768670003333 active site 768670003334 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 768670003335 putative active site pocket [active] 768670003336 dimerization interface [polypeptide binding]; other site 768670003337 putative catalytic residue [active] 768670003338 MOSC domain; Region: MOSC; pfam03473 768670003339 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 768670003340 MPT binding site; other site 768670003341 trimer interface [polypeptide binding]; other site 768670003342 thymidylate kinase; Validated; Region: tmk; PRK00698 768670003343 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 768670003344 TMP-binding site; other site 768670003345 ATP-binding site [chemical binding]; other site 768670003346 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 768670003347 DNA polymerase III subunit delta'; Validated; Region: PRK08485 768670003348 ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470 768670003349 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 768670003350 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 768670003351 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 768670003352 active site 768670003353 HIGH motif; other site 768670003354 KMSKS motif; other site 768670003355 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 768670003356 anticodon binding site; other site 768670003357 tRNA binding surface [nucleotide binding]; other site 768670003358 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 768670003359 dimer interface [polypeptide binding]; other site 768670003360 putative tRNA-binding site [nucleotide binding]; other site 768670003361 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 768670003362 active site 768670003363 Response regulator receiver domain; Region: Response_reg; pfam00072 768670003364 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768670003365 active site 768670003366 phosphorylation site [posttranslational modification] 768670003367 intermolecular recognition site; other site 768670003368 dimerization interface [polypeptide binding]; other site 768670003369 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 768670003370 Ligand Binding Site [chemical binding]; other site 768670003371 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 768670003372 active site 1 [active] 768670003373 dimer interface [polypeptide binding]; other site 768670003374 hexamer interface [polypeptide binding]; other site 768670003375 active site 2 [active] 768670003376 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 768670003377 FHIPEP family; Region: FHIPEP; pfam00771 768670003378 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 768670003379 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 768670003380 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 768670003381 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 768670003382 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 768670003383 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768670003384 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 768670003385 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768670003386 DNA binding residues [nucleotide binding] 768670003387 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 768670003388 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768670003389 active site 768670003390 phosphorylation site [posttranslational modification] 768670003391 intermolecular recognition site; other site 768670003392 dimerization interface [polypeptide binding]; other site 768670003393 CheB methylesterase; Region: CheB_methylest; pfam01339 768670003394 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 768670003395 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 768670003396 flagellar motor switch protein FliY; Validated; Region: PRK08432 768670003397 flagellar motor switch protein FliN; Region: fliN; TIGR02480 768670003398 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 768670003399 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768670003400 active site 768670003401 phosphorylation site [posttranslational modification] 768670003402 intermolecular recognition site; other site 768670003403 dimerization interface [polypeptide binding]; other site 768670003404 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 768670003405 putative binding surface; other site 768670003406 active site 768670003407 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 768670003408 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 768670003409 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768670003410 ATP binding site [chemical binding]; other site 768670003411 Mg2+ binding site [ion binding]; other site 768670003412 G-X-G motif; other site 768670003413 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 768670003414 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768670003415 Response regulator receiver domain; Region: Response_reg; pfam00072 768670003416 active site 768670003417 phosphorylation site [posttranslational modification] 768670003418 intermolecular recognition site; other site 768670003419 dimerization interface [polypeptide binding]; other site 768670003420 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 768670003421 PAS domain; Region: PAS_9; pfam13426 768670003422 putative active site [active] 768670003423 heme pocket [chemical binding]; other site 768670003424 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 768670003425 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 768670003426 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 768670003427 anti sigma factor interaction site; other site 768670003428 regulatory phosphorylation site [posttranslational modification]; other site 768670003429 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 768670003430 anti sigma factor interaction site; other site 768670003431 regulatory phosphorylation site [posttranslational modification]; other site 768670003432 HEAT repeats; Region: HEAT_2; pfam13646 768670003433 HEAT repeats; Region: HEAT_2; pfam13646 768670003434 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 768670003435 protein binding surface [polypeptide binding]; other site 768670003436 HEAT repeats; Region: HEAT_2; pfam13646 768670003437 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 768670003438 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 768670003439 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 768670003440 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 768670003441 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768670003442 S-adenosylmethionine binding site [chemical binding]; other site 768670003443 RmuC family; Region: RmuC; pfam02646 768670003444 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 768670003445 HIT family signature motif; other site 768670003446 catalytic residue [active] 768670003447 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 768670003448 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 768670003449 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 768670003450 protein binding site [polypeptide binding]; other site 768670003451 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 768670003452 protein binding site [polypeptide binding]; other site 768670003453 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 768670003454 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 768670003455 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 768670003456 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 768670003457 protein binding site [polypeptide binding]; other site 768670003458 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 768670003459 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768670003460 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768670003461 DNA binding residues [nucleotide binding] 768670003462 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 768670003463 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 768670003464 dimer interface [polypeptide binding]; other site 768670003465 putative CheW interface [polypeptide binding]; other site 768670003466 Hemerythrin; Region: Hemerythrin; cd12107 768670003467 Fe binding site [ion binding]; other site 768670003468 Late competence development protein ComFB; Region: ComFB; pfam10719 768670003469 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 768670003470 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 768670003471 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 768670003472 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 768670003473 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 768670003474 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 768670003475 homodimer interface [polypeptide binding]; other site 768670003476 substrate-cofactor binding pocket; other site 768670003477 catalytic residue [active] 768670003478 GTPase Era; Reviewed; Region: era; PRK00089 768670003479 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 768670003480 G1 box; other site 768670003481 GTP/Mg2+ binding site [chemical binding]; other site 768670003482 Switch I region; other site 768670003483 G2 box; other site 768670003484 Switch II region; other site 768670003485 G3 box; other site 768670003486 G4 box; other site 768670003487 G5 box; other site 768670003488 KH domain; Region: KH_2; pfam07650 768670003489 Domain of unknown function DUF21; Region: DUF21; pfam01595 768670003490 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 768670003491 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 768670003492 Transporter associated domain; Region: CorC_HlyC; smart01091 768670003493 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 768670003494 PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like phosphatase domains appear fused to E. coli DAGK-like trans-membrane diacylglycerol kinase domains. The cellular function of these architectures remains to be...; Region: PAP2_diacylglycerolkinase; cd03383 768670003495 active site 768670003496 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 768670003497 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl17245 768670003498 nucleic acid binding region [nucleotide binding]; other site 768670003499 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 768670003500 G-X-X-G motif; other site 768670003501 PhoH-like protein; Region: PhoH; pfam02562 768670003502 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 768670003503 DHH family; Region: DHH; pfam01368 768670003504 FOG: CBS domain [General function prediction only]; Region: COG0517 768670003505 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595 768670003506 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 768670003507 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 768670003508 active site 768670003509 NTP binding site [chemical binding]; other site 768670003510 metal binding triad [ion binding]; metal-binding site 768670003511 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 768670003512 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 768670003513 active site 768670003514 DNA binding site [nucleotide binding] 768670003515 Int/Topo IB signature motif; other site 768670003516 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 768670003517 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 768670003518 Walker A/P-loop; other site 768670003519 ATP binding site [chemical binding]; other site 768670003520 Q-loop/lid; other site 768670003521 ABC transporter signature motif; other site 768670003522 Walker B; other site 768670003523 D-loop; other site 768670003524 H-loop/switch region; other site 768670003525 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 768670003526 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 768670003527 Peptidase family M23; Region: Peptidase_M23; pfam01551 768670003528 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 768670003529 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 768670003530 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 768670003531 protein binding site [polypeptide binding]; other site 768670003532 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 768670003533 Catalytic dyad [active] 768670003534 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 768670003535 NodB motif; other site 768670003536 putative active site [active] 768670003537 putative catalytic site [active] 768670003538 Zn binding site [ion binding]; other site 768670003539 UGMP family protein; Validated; Region: PRK09604 768670003540 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 768670003541 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 768670003542 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 768670003543 FMN binding site [chemical binding]; other site 768670003544 active site 768670003545 catalytic residues [active] 768670003546 substrate binding site [chemical binding]; other site 768670003547 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 768670003548 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 768670003549 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 768670003550 Glutamine amidotransferase class-I; Region: GATase; pfam00117 768670003551 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 768670003552 glutamine binding [chemical binding]; other site 768670003553 catalytic triad [active] 768670003554 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 768670003555 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 768670003556 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 768670003557 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 768670003558 active site 768670003559 ribulose/triose binding site [chemical binding]; other site 768670003560 phosphate binding site [ion binding]; other site 768670003561 substrate (anthranilate) binding pocket [chemical binding]; other site 768670003562 product (indole) binding pocket [chemical binding]; other site 768670003563 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 768670003564 active site 768670003565 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 768670003566 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 768670003567 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768670003568 catalytic residue [active] 768670003569 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 768670003570 substrate binding site [chemical binding]; other site 768670003571 active site 768670003572 catalytic residues [active] 768670003573 heterodimer interface [polypeptide binding]; other site 768670003574 prolyl-tRNA synthetase; Provisional; Region: PRK09194 768670003575 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 768670003576 dimer interface [polypeptide binding]; other site 768670003577 motif 1; other site 768670003578 active site 768670003579 motif 2; other site 768670003580 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 768670003581 putative deacylase active site [active] 768670003582 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 768670003583 active site 768670003584 motif 3; other site 768670003585 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 768670003586 anticodon binding site; other site 768670003587 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 768670003588 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 768670003589 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 768670003590 substrate binding site [chemical binding]; other site 768670003591 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 768670003592 substrate binding site [chemical binding]; other site 768670003593 ligand binding site [chemical binding]; other site 768670003594 fumarate hydratase; Provisional; Region: PRK15389 768670003595 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 768670003596 Fumarase C-terminus; Region: Fumerase_C; pfam05683 768670003597 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 768670003598 active site 768670003599 dimer interface [polypeptide binding]; other site 768670003600 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768670003601 active site 768670003602 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 768670003603 N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796 768670003604 putative active site [active] 768670003605 catalytic site [active] 768670003606 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 768670003607 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 768670003608 active site 768670003609 Substrate binding site; other site 768670003610 Mg++ binding site; other site 768670003611 Left-handed parallel beta-Helix (LbH) domain of a group of proteins with similarity to glucose-1-phosphate adenylyltransferase: Included in this family are glucose-1-phosphate adenylyltransferase, mannose-1-phosphate guanylyltransferase, and the...; Region: LbH_G1P_AT_C_like; cd03356 768670003612 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 768670003613 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 768670003614 active site 768670003615 substrate binding site [chemical binding]; other site 768670003616 metal binding site [ion binding]; metal-binding site 768670003617 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 768670003618 putative homodimer interface [polypeptide binding]; other site 768670003619 putative active site pocket [active] 768670003620 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 768670003621 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 768670003622 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 768670003623 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 768670003624 generic binding surface II; other site 768670003625 ssDNA binding site; other site 768670003626 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768670003627 ATP binding site [chemical binding]; other site 768670003628 putative Mg++ binding site [ion binding]; other site 768670003629 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768670003630 nucleotide binding region [chemical binding]; other site 768670003631 ATP-binding site [chemical binding]; other site 768670003632 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 768670003633 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 768670003634 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 768670003635 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 768670003636 NAD binding site [chemical binding]; other site 768670003637 homotetramer interface [polypeptide binding]; other site 768670003638 homodimer interface [polypeptide binding]; other site 768670003639 substrate binding site [chemical binding]; other site 768670003640 active site 768670003641 DNA repair protein RadA; Provisional; Region: PRK11823 768670003642 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 768670003643 Walker A motif; other site 768670003644 ATP binding site [chemical binding]; other site 768670003645 Walker B motif; other site 768670003646 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 768670003647 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 768670003648 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768670003649 Walker A motif; other site 768670003650 ATP binding site [chemical binding]; other site 768670003651 Walker B motif; other site 768670003652 arginine finger; other site 768670003653 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 768670003654 4Fe-4S binding domain; Region: Fer4; pfam00037 768670003655 AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335 768670003656 AMMECR1; Region: AMMECR1; pfam01871 768670003657 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 768670003658 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 768670003659 ATP binding site [chemical binding]; other site 768670003660 Mg++ binding site [ion binding]; other site 768670003661 motif III; other site 768670003662 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768670003663 nucleotide binding region [chemical binding]; other site 768670003664 ATP-binding site [chemical binding]; other site 768670003665 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 768670003666 RNA binding site [nucleotide binding]; other site 768670003667 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 768670003668 Putative catalytic NodB homology domain of uncharacterized BH0857 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH0857_like; cd10955 768670003669 NodB motif; other site 768670003670 putative active site [active] 768670003671 putative catalytic site [active] 768670003672 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 768670003673 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 768670003674 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 768670003675 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 768670003676 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 768670003677 ATP-grasp domain; Region: ATP-grasp_4; cl17255 768670003678 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 768670003679 IMP binding site; other site 768670003680 dimer interface [polypeptide binding]; other site 768670003681 interdomain contacts; other site 768670003682 partial ornithine binding site; other site 768670003683 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 768670003684 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 768670003685 FAD binding pocket [chemical binding]; other site 768670003686 FAD binding motif [chemical binding]; other site 768670003687 phosphate binding motif [ion binding]; other site 768670003688 beta-alpha-beta structure motif; other site 768670003689 NAD binding pocket [chemical binding]; other site 768670003690 Iron coordination center [ion binding]; other site 768670003691 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 768670003692 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 768670003693 heterodimer interface [polypeptide binding]; other site 768670003694 active site 768670003695 FMN binding site [chemical binding]; other site 768670003696 homodimer interface [polypeptide binding]; other site 768670003697 substrate binding site [chemical binding]; other site 768670003698 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 768670003699 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 768670003700 ligand binding site [chemical binding]; other site 768670003701 FecR protein; Region: FecR; pfam04773 768670003702 Curli production assembly/transport component CsgG; Region: CsgG; cl17434 768670003703 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 768670003704 Fe-S cluster binding site [ion binding]; other site 768670003705 active site 768670003706 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 768670003707 Flavoprotein; Region: Flavoprotein; pfam02441 768670003708 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 768670003709 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 768670003710 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 768670003711 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 768670003712 catalytic site [active] 768670003713 G-X2-G-X-G-K; other site 768670003714 hypothetical protein; Provisional; Region: PRK11820 768670003715 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 768670003716 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 768670003717 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 768670003718 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 768670003719 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246 768670003720 FeoA domain; Region: FeoA; pfam04023 768670003721 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 768670003722 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 768670003723 G1 box; other site 768670003724 GTP/Mg2+ binding site [chemical binding]; other site 768670003725 Switch I region; other site 768670003726 G2 box; other site 768670003727 G3 box; other site 768670003728 Switch II region; other site 768670003729 G4 box; other site 768670003730 G5 box; other site 768670003731 Nucleoside recognition; Region: Gate; pfam07670 768670003732 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 768670003733 Nucleoside recognition; Region: Gate; pfam07670 768670003734 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 768670003735 Malic enzyme, N-terminal domain; Region: malic; pfam00390 768670003736 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 768670003737 putative NAD(P) binding site [chemical binding]; other site 768670003738 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 768670003739 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768670003740 PAS fold; Region: PAS_3; pfam08447 768670003741 putative active site [active] 768670003742 heme pocket [chemical binding]; other site 768670003743 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768670003744 PAS fold; Region: PAS_3; pfam08447 768670003745 putative active site [active] 768670003746 heme pocket [chemical binding]; other site 768670003747 PAS domain S-box; Region: sensory_box; TIGR00229 768670003748 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768670003749 putative active site [active] 768670003750 heme pocket [chemical binding]; other site 768670003751 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768670003752 dimer interface [polypeptide binding]; other site 768670003753 phosphorylation site [posttranslational modification] 768670003754 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768670003755 ATP binding site [chemical binding]; other site 768670003756 Mg2+ binding site [ion binding]; other site 768670003757 G-X-G motif; other site 768670003758 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768670003759 Response regulator receiver domain; Region: Response_reg; pfam00072 768670003760 active site 768670003761 phosphorylation site [posttranslational modification] 768670003762 intermolecular recognition site; other site 768670003763 dimerization interface [polypeptide binding]; other site 768670003764 Hpt domain; Region: Hpt; pfam01627 768670003765 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 768670003766 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768670003767 active site 768670003768 phosphorylation site [posttranslational modification] 768670003769 intermolecular recognition site; other site 768670003770 dimerization interface [polypeptide binding]; other site 768670003771 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 768670003772 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768670003773 metal binding site [ion binding]; metal-binding site 768670003774 active site 768670003775 I-site; other site 768670003776 Transglycosylase SLT domain; Region: SLT_2; pfam13406 768670003777 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 768670003778 N-acetyl-D-glucosamine binding site [chemical binding]; other site 768670003779 Haemolytic domain; Region: Haemolytic; pfam01809 768670003780 membrane protein insertase; Provisional; Region: PRK01318 768670003781 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 768670003782 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 768670003783 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 768670003784 G-X-X-G motif; other site 768670003785 R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich...; Region: R3H; cl00297 768670003786 RxxxH motif; other site 768670003787 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 768670003788 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 768670003789 active site 768670003790 intersubunit interactions; other site 768670003791 catalytic residue [active] 768670003792 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 768670003793 putative FMN binding site [chemical binding]; other site 768670003794 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 768670003795 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 768670003796 DNA binding residues [nucleotide binding] 768670003797 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 768670003798 IHF - DNA interface [nucleotide binding]; other site 768670003799 IHF dimer interface [polypeptide binding]; other site 768670003800 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 768670003801 elongation factor G; Reviewed; Region: PRK12740 768670003802 G1 box; other site 768670003803 putative GEF interaction site [polypeptide binding]; other site 768670003804 GTP/Mg2+ binding site [chemical binding]; other site 768670003805 Switch I region; other site 768670003806 G2 box; other site 768670003807 G3 box; other site 768670003808 Switch II region; other site 768670003809 G4 box; other site 768670003810 G5 box; other site 768670003811 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 768670003812 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 768670003813 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 768670003814 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 768670003815 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768670003816 substrate binding pocket [chemical binding]; other site 768670003817 membrane-bound complex binding site; other site 768670003818 hinge residues; other site 768670003819 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 768670003820 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768670003821 dimer interface [polypeptide binding]; other site 768670003822 phosphorylation site [posttranslational modification] 768670003823 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768670003824 ATP binding site [chemical binding]; other site 768670003825 Mg2+ binding site [ion binding]; other site 768670003826 G-X-G motif; other site 768670003827 Ribosomal protein S21; Region: Ribosomal_S21; pfam01165 768670003828 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 768670003829 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768670003830 Walker A motif; other site 768670003831 ATP binding site [chemical binding]; other site 768670003832 Walker B motif; other site 768670003833 arginine finger; other site 768670003834 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 768670003835 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 768670003836 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 768670003837 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768670003838 Walker B motif; other site 768670003839 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 768670003840 Clp protease; Region: CLP_protease; pfam00574 768670003841 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 768670003842 oligomer interface [polypeptide binding]; other site 768670003843 active site residues [active] 768670003844 trigger factor; Region: tig; TIGR00115 768670003845 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 768670003846 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 768670003847 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 768670003848 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 768670003849 putative dimer interface [polypeptide binding]; other site 768670003850 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 768670003851 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768670003852 FeS/SAM binding site; other site 768670003853 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 768670003854 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 768670003855 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 768670003856 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 768670003857 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 768670003858 dimer interface [polypeptide binding]; other site 768670003859 substrate binding site [chemical binding]; other site 768670003860 metal binding site [ion binding]; metal-binding site 768670003861 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 768670003862 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 768670003863 GatB domain; Region: GatB_Yqey; smart00845 768670003864 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777 768670003865 putative active site pocket [active] 768670003866 dimerization interface [polypeptide binding]; other site 768670003867 putative catalytic residue [active] 768670003868 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 768670003869 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768670003870 S-adenosylmethionine binding site [chemical binding]; other site 768670003871 Protein of unknown function (DUF452); Region: DUF452; cl01062 768670003872 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 768670003873 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 768670003874 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768670003875 catalytic residue [active] 768670003876 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 768670003877 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 768670003878 inhibitor-cofactor binding pocket; inhibition site 768670003879 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768670003880 catalytic residue [active] 768670003881 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 768670003882 amidophosphoribosyltransferase; Provisional; Region: PRK09123 768670003883 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 768670003884 active site 768670003885 tetramer interface [polypeptide binding]; other site 768670003886 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768670003887 active site 768670003888 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 768670003889 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 768670003890 dimerization interface [polypeptide binding]; other site 768670003891 ATP binding site [chemical binding]; other site 768670003892 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 768670003893 dimerization interface [polypeptide binding]; other site 768670003894 ATP binding site [chemical binding]; other site 768670003895 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 768670003896 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 768670003897 putative active site [active] 768670003898 catalytic triad [active] 768670003899 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 768670003900 multifunctional aminopeptidase A; Provisional; Region: PRK00913 768670003901 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 768670003902 interface (dimer of trimers) [polypeptide binding]; other site 768670003903 Substrate-binding/catalytic site; other site 768670003904 Zn-binding sites [ion binding]; other site 768670003905 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 768670003906 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768670003907 TPR motif; other site 768670003908 TPR repeat; Region: TPR_11; pfam13414 768670003909 binding surface 768670003910 Curli production assembly/transport component CsgG; Region: CsgG; cl17434 768670003911 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cl00399 768670003912 MoaD interaction [polypeptide binding]; other site 768670003913 active site residues [active] 768670003914 aconitate hydratase; Validated; Region: PRK09277 768670003915 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 768670003916 substrate binding site [chemical binding]; other site 768670003917 ligand binding site [chemical binding]; other site 768670003918 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 768670003919 substrate binding site [chemical binding]; other site 768670003920 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 768670003921 Thioredoxin; Region: Thioredoxin_4; cl17273 768670003922 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 768670003923 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 768670003924 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 768670003925 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 768670003926 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768670003927 ATP binding site [chemical binding]; other site 768670003928 Mg2+ binding site [ion binding]; other site 768670003929 G-X-G motif; other site 768670003930 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 768670003931 ATP binding site [chemical binding]; other site 768670003932 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 768670003933 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 768670003934 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 768670003935 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768670003936 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 768670003937 non-specific DNA binding site [nucleotide binding]; other site 768670003938 salt bridge; other site 768670003939 sequence-specific DNA binding site [nucleotide binding]; other site 768670003940 Cupin domain; Region: Cupin_2; pfam07883 768670003941 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 768670003942 IHF dimer interface [polypeptide binding]; other site 768670003943 IHF - DNA interface [nucleotide binding]; other site 768670003944 Transposase, Mutator family; Region: Transposase_mut; pfam00872 768670003945 MULE transposase domain; Region: MULE; pfam10551 768670003946 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 768670003947 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 768670003948 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 768670003949 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 768670003950 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 768670003951 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 768670003952 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 768670003953 putative active site [active] 768670003954 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 768670003955 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 768670003956 putative active site [active] 768670003957 O-Antigen ligase; Region: Wzy_C; pfam04932 768670003958 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 768670003959 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 768670003960 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 768670003961 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 768670003962 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 768670003963 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 768670003964 purine monophosphate binding site [chemical binding]; other site 768670003965 dimer interface [polypeptide binding]; other site 768670003966 putative catalytic residues [active] 768670003967 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 768670003968 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 768670003969 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 768670003970 lipoprotein signal peptidase; Provisional; Region: PRK14787 768670003971 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 768670003972 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 768670003973 active site 768670003974 HIGH motif; other site 768670003975 nucleotide binding site [chemical binding]; other site 768670003976 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 768670003977 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 768670003978 active site 768670003979 KMSKS motif; other site 768670003980 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 768670003981 tRNA binding surface [nucleotide binding]; other site 768670003982 anticodon binding site; other site 768670003983 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 768670003984 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 768670003985 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 768670003986 nucleotide binding site [chemical binding]; other site 768670003987 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 768670003988 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 768670003989 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 768670003990 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 768670003991 P loop; other site 768670003992 GTP binding site [chemical binding]; other site 768670003993 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 768670003994 Part of AAA domain; Region: AAA_19; pfam13245 768670003995 Family description; Region: UvrD_C_2; pfam13538 768670003996 arginine decarboxylase; Provisional; Region: PRK05354 768670003997 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 768670003998 dimer interface [polypeptide binding]; other site 768670003999 active site 768670004000 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 768670004001 catalytic residues [active] 768670004002 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 768670004003 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 768670004004 Transcriptional regulator [Transcription]; Region: IclR; COG1414 768670004005 Bacterial transcriptional regulator; Region: IclR; pfam01614 768670004006 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 768670004007 Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242 768670004008 Cytochrome c; Region: Cytochrom_C; cl11414 768670004009 Cytochrome c; Region: Cytochrom_C; cl11414 768670004010 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 768670004011 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 768670004012 catalytic residues [active] 768670004013 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 768670004014 PAS domain; Region: PAS_10; pfam13596 768670004015 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 768670004016 putative active site [active] 768670004017 heme pocket [chemical binding]; other site 768670004018 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 768670004019 substrate binding site; other site 768670004020 dimer interface; other site 768670004021 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 768670004022 putative active site [active] 768670004023 YGGT family; Region: YGGT; pfam02325 768670004024 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 768670004025 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 768670004026 catalytic residue [active] 768670004027 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 768670004028 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 768670004029 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 768670004030 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 768670004031 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 768670004032 putative acyl-acceptor binding pocket; other site 768670004033 selenocysteine-specific elongation factor SelB; Region: selB; TIGR00475 768670004034 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 768670004035 G1 box; other site 768670004036 GTP/Mg2+ binding site [chemical binding]; other site 768670004037 G2 box; other site 768670004038 Switch I region; other site 768670004039 G3 box; other site 768670004040 Switch II region; other site 768670004041 G4 box; other site 768670004042 G5 box; other site 768670004043 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 768670004044 selenocysteine synthase; Provisional; Region: PRK04311 768670004045 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 768670004046 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768670004047 catalytic residue [active] 768670004048 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 768670004049 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 768670004050 metal binding site [ion binding]; metal-binding site 768670004051 dimer interface [polypeptide binding]; other site 768670004052 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 768670004053 DNA protecting protein DprA; Region: dprA; TIGR00732 768670004054 DNA topoisomerase I; Validated; Region: PRK06599 768670004055 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 768670004056 active site 768670004057 interdomain interaction site; other site 768670004058 putative metal-binding site [ion binding]; other site 768670004059 nucleotide binding site [chemical binding]; other site 768670004060 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 768670004061 domain I; other site 768670004062 DNA binding groove [nucleotide binding] 768670004063 phosphate binding site [ion binding]; other site 768670004064 domain II; other site 768670004065 domain III; other site 768670004066 nucleotide binding site [chemical binding]; other site 768670004067 catalytic site [active] 768670004068 domain IV; other site 768670004069 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 768670004070 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 768670004071 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 768670004072 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 768670004073 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 768670004074 Glucose inhibited division protein A; Region: GIDA; pfam01134 768670004075 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 768670004076 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 768670004077 active site 768670004078 DNA binding site [nucleotide binding] 768670004079 Int/Topo IB signature motif; other site 768670004080 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 768670004081 Protein of unknown function (DUF3617); Region: DUF3617; pfam12276 768670004082 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 768670004083 uncharacterized radical SAM protein YgiQ; Region: SAM_YgiQ; TIGR03904 768670004084 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 768670004085 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 768670004086 EamA-like transporter family; Region: EamA; pfam00892 768670004087 EamA-like transporter family; Region: EamA; pfam00892 768670004088 Domain of unknown function (DUF2703); Region: DUF2703; pfam10865 768670004089 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 768670004090 tetramerization interface [polypeptide binding]; other site 768670004091 active site 768670004092 pantoate--beta-alanine ligase; Region: panC; TIGR00018 768670004093 Pantoate-beta-alanine ligase; Region: PanC; cd00560 768670004094 active site 768670004095 ATP-binding site [chemical binding]; other site 768670004096 pantoate-binding site; other site 768670004097 HXXH motif; other site 768670004098 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 768670004099 oligomerization interface [polypeptide binding]; other site 768670004100 active site 768670004101 metal binding site [ion binding]; metal-binding site 768670004102 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 768670004103 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768670004104 non-specific DNA binding site [nucleotide binding]; other site 768670004105 salt bridge; other site 768670004106 sequence-specific DNA binding site [nucleotide binding]; other site 768670004107 Cupin domain; Region: Cupin_2; pfam07883 768670004108 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768670004109 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768670004110 dimer interface [polypeptide binding]; other site 768670004111 phosphorylation site [posttranslational modification] 768670004112 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768670004113 ATP binding site [chemical binding]; other site 768670004114 Mg2+ binding site [ion binding]; other site 768670004115 G-X-G motif; other site 768670004116 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 768670004117 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 768670004118 trimer interface [polypeptide binding]; other site 768670004119 putative metal binding site [ion binding]; other site 768670004120 enolase; Provisional; Region: eno; PRK00077 768670004121 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 768670004122 dimer interface [polypeptide binding]; other site 768670004123 metal binding site [ion binding]; metal-binding site 768670004124 substrate binding pocket [chemical binding]; other site 768670004125 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 768670004126 L-aspartate oxidase; Provisional; Region: PRK06175 768670004127 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 768670004128 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 768670004129 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768670004130 S-adenosylmethionine binding site [chemical binding]; other site 768670004131 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 768670004132 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 768670004133 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 768670004134 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 768670004135 ligand binding site [chemical binding]; other site 768670004136 NAD binding site [chemical binding]; other site 768670004137 dimerization interface [polypeptide binding]; other site 768670004138 catalytic site [active] 768670004139 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 768670004140 putative L-serine binding site [chemical binding]; other site 768670004141 Curli production assembly/transport component CsgG; Region: CsgG; cl17434 768670004142 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 768670004143 TPR motif; other site 768670004144 TPR repeat; Region: TPR_11; pfam13414 768670004145 binding surface 768670004146 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 768670004147 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 768670004148 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 768670004149 Predicted permeases [General function prediction only]; Region: RarD; COG2962 768670004150 EamA-like transporter family; Region: EamA; cl17759 768670004151 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 768670004152 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 768670004153 putative dimer interface [polypeptide binding]; other site 768670004154 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 768670004155 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 768670004156 HSP70 interaction site [polypeptide binding]; other site 768670004157 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 768670004158 substrate binding site [polypeptide binding]; other site 768670004159 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 768670004160 Zn binding sites [ion binding]; other site 768670004161 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 768670004162 dimer interface [polypeptide binding]; other site 768670004163 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 768670004164 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 768670004165 DNA binding residues [nucleotide binding] 768670004166 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 768670004167 Clp amino terminal domain; Region: Clp_N; pfam02861 768670004168 Clp amino terminal domain; Region: Clp_N; pfam02861 768670004169 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768670004170 Walker A motif; other site 768670004171 ATP binding site [chemical binding]; other site 768670004172 Walker B motif; other site 768670004173 arginine finger; other site 768670004174 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768670004175 Walker A motif; other site 768670004176 ATP binding site [chemical binding]; other site 768670004177 Walker B motif; other site 768670004178 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 768670004179 DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) [Transcription]; Region: RpoD; COG0568 768670004180 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 768670004181 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768670004182 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 768670004183 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768670004184 DNA binding residues [nucleotide binding] 768670004185 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 768670004186 Active_site [active] 768670004187 Chain length determinant protein; Region: Wzz; cl15801 768670004188 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 768670004189 Haemagglutinin; Region: Hemagglutinin; pfam00509 768670004190 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 768670004191 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768670004192 Walker A motif; other site 768670004193 ATP binding site [chemical binding]; other site 768670004194 Walker B motif; other site 768670004195 Archaeal ATPase; Region: Arch_ATPase; pfam01637 768670004196 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 768670004197 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 768670004198 This subfamily is composed of uncharacterized bacterial glycosyltransferases in the MraY-like family. This family contains both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases, which...; Region: GT_MraY_like; cd06912 768670004199 Mg++ binding site [ion binding]; other site 768670004200 putative catalytic motif [active] 768670004201 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 768670004202 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 768670004203 active site 768670004204 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 768670004205 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 768670004206 active site 768670004207 Alpha-1,2-fucosyltransferase; Region: Fut1_Fut2_like; cd11301 768670004208 Glycosyl transferase family 11; Region: Glyco_transf_11; pfam01531 768670004209 GDP-Fucose binding site [chemical binding]; other site 768670004210 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 768670004211 active site 768670004212 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914 768670004213 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 768670004214 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 768670004215 active site 768670004216 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 768670004217 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 768670004218 active site 768670004219 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 768670004220 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 768670004221 Cephalosporin hydroxylase; Region: CmcI; pfam04989 768670004222 Methyltransferase domain; Region: Methyltransf_23; pfam13489 768670004223 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 768670004224 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 768670004225 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 768670004226 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768670004227 NAD(P) binding site [chemical binding]; other site 768670004228 active site 768670004229 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 768670004230 Methyltransferase domain; Region: Methyltransf_23; pfam13489 768670004231 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768670004232 S-adenosylmethionine binding site [chemical binding]; other site 768670004233 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 768670004234 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 768670004235 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 768670004236 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 768670004237 NAD binding site [chemical binding]; other site 768670004238 homotetramer interface [polypeptide binding]; other site 768670004239 homodimer interface [polypeptide binding]; other site 768670004240 substrate binding site [chemical binding]; other site 768670004241 active site 768670004242 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 768670004243 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 768670004244 substrate binding site; other site 768670004245 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 768670004246 four helix bundle protein; Region: TIGR02436 768670004247 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 768670004248 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 768670004249 NADP binding site [chemical binding]; other site 768670004250 active site 768670004251 putative substrate binding site [chemical binding]; other site 768670004252 hypothetical protein; Reviewed; Region: PRK12275 768670004253 four helix bundle protein; Region: TIGR02436 768670004254 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 768670004255 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 768670004256 NADP-binding site; other site 768670004257 homotetramer interface [polypeptide binding]; other site 768670004258 substrate binding site [chemical binding]; other site 768670004259 homodimer interface [polypeptide binding]; other site 768670004260 active site 768670004261 Haemagglutinin; Region: Hemagglutinin; pfam00509 768670004262 Haemagglutinin; Region: Hemagglutinin; pfam00509 768670004263 Bacterial sugar transferase; Region: Bac_transf; pfam02397 768670004264 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 768670004265 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 768670004266 putative ADP-binding pocket [chemical binding]; other site 768670004267 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 768670004268 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 768670004269 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 768670004270 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 768670004271 Probable Catalytic site; other site 768670004272 metal-binding site 768670004273 Methyltransferase domain; Region: Methyltransf_23; pfam13489 768670004274 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768670004275 S-adenosylmethionine binding site [chemical binding]; other site 768670004276 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 768670004277 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 768670004278 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 768670004279 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 768670004280 active site 768670004281 homodimer interface [polypeptide binding]; other site 768670004282 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 768670004283 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 768670004284 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 768670004285 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 768670004286 NAD binding site [chemical binding]; other site 768670004287 substrate binding site [chemical binding]; other site 768670004288 homodimer interface [polypeptide binding]; other site 768670004289 active site 768670004290 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 768670004291 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 768670004292 NADP binding site [chemical binding]; other site 768670004293 active site 768670004294 putative substrate binding site [chemical binding]; other site 768670004295 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 768670004296 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 768670004297 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 768670004298 substrate binding site; other site 768670004299 tetramer interface; other site 768670004300 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 768670004301 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 768670004302 Substrate binding site; other site 768670004303 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 768670004304 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 768670004305 Predicted membrane protein [Function unknown]; Region: COG1971 768670004306 Domain of unknown function DUF; Region: DUF204; pfam02659 768670004307 Domain of unknown function DUF; Region: DUF204; pfam02659 768670004308 Predicted permease [General function prediction only]; Region: COG2985 768670004309 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 768670004310 TrkA-C domain; Region: TrkA_C; pfam02080 768670004311 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 768670004312 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 768670004313 pyrroline-5-carboxylate reductase; Region: PLN02688 768670004314 Esterase/lipase [General function prediction only]; Region: COG1647 768670004315 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 768670004316 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 768670004317 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768670004318 putative DNA binding site [nucleotide binding]; other site 768670004319 putative Zn2+ binding site [ion binding]; other site 768670004320 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 768670004321 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 768670004322 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 768670004323 Predicted kinase [General function prediction only]; Region: COG0645 768670004324 Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516 768670004325 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 768670004326 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 768670004327 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 768670004328 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768670004329 motif II; other site 768670004330 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 768670004331 active site 768670004332 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 768670004333 active site 2 [active] 768670004334 active site 1 [active] 768670004335 glutamate racemase; Provisional; Region: PRK00865 768670004336 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 768670004337 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 768670004338 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768670004339 active site 768670004340 phosphorylation site [posttranslational modification] 768670004341 intermolecular recognition site; other site 768670004342 dimerization interface [polypeptide binding]; other site 768670004343 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768670004344 DNA binding site [nucleotide binding] 768670004345 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 768670004346 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 768670004347 putative active site [active] 768670004348 dimerization interface [polypeptide binding]; other site 768670004349 putative tRNAtyr binding site [nucleotide binding]; other site 768670004350 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 768670004351 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 768670004352 Domain of unknown function (DUF814); Region: DUF814; pfam05670 768670004353 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 768670004354 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 768670004355 Walker A motif; other site 768670004356 ATP binding site [chemical binding]; other site 768670004357 Walker B motif; other site 768670004358 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 768670004359 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 768670004360 active site 768670004361 catalytic site [active] 768670004362 substrate binding site [chemical binding]; other site 768670004363 LPP20 lipoprotein; Region: LPP20; cl15824 768670004364 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 768670004365 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 768670004366 MutS domain III; Region: MutS_III; pfam05192 768670004367 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768670004368 Walker A/P-loop; other site 768670004369 ATP binding site [chemical binding]; other site 768670004370 Q-loop/lid; other site 768670004371 ABC transporter signature motif; other site 768670004372 Walker B; other site 768670004373 D-loop; other site 768670004374 H-loop/switch region; other site 768670004375 Smr domain; Region: Smr; pfam01713 768670004376 Colicin V production protein; Region: Colicin_V; pfam02674 768670004377 Yqey-like protein; Region: YqeY; pfam09424 768670004378 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 768670004379 6-phosphofructokinase; Provisional; Region: PRK03202 768670004380 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 768670004381 active site 768670004382 ADP/pyrophosphate binding site [chemical binding]; other site 768670004383 dimerization interface [polypeptide binding]; other site 768670004384 allosteric effector site; other site 768670004385 fructose-1,6-bisphosphate binding site; other site 768670004386 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 768670004387 Ligand Binding Site [chemical binding]; other site 768670004388 Cation transport protein; Region: TrkH; cl17365 768670004389 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 768670004390 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 768670004391 TrkA-N domain; Region: TrkA_N; pfam02254 768670004392 TrkA-C domain; Region: TrkA_C; pfam02080 768670004393 TrkA-N domain; Region: TrkA_N; pfam02254 768670004394 TrkA-C domain; Region: TrkA_C; pfam02080 768670004395 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 768670004396 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 768670004397 putative phosphate acyltransferase; Provisional; Region: PRK05331 768670004398 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 768670004399 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 768670004400 dimer interface [polypeptide binding]; other site 768670004401 active site 768670004402 CoA binding pocket [chemical binding]; other site 768670004403 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 768670004404 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 768670004405 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 768670004406 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 768670004407 NAD(P) binding site [chemical binding]; other site 768670004408 homotetramer interface [polypeptide binding]; other site 768670004409 homodimer interface [polypeptide binding]; other site 768670004410 active site 768670004411 acyl carrier protein; Provisional; Region: acpP; PRK00982 768670004412 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 768670004413 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 768670004414 dimer interface [polypeptide binding]; other site 768670004415 active site 768670004416 ribonuclease III; Reviewed; Region: rnc; PRK00102 768670004417 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 768670004418 dimerization interface [polypeptide binding]; other site 768670004419 active site 768670004420 metal binding site [ion binding]; metal-binding site 768670004421 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 768670004422 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768670004423 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 768670004424 FeS/SAM binding site; other site 768670004425 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 768670004426 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768670004427 S-adenosylmethionine binding site [chemical binding]; other site 768670004428 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 768670004429 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 768670004430 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 768670004431 RuvA N terminal domain; Region: RuvA_N; pfam01330 768670004432 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 768670004433 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 768670004434 active site 768670004435 putative DNA-binding cleft [nucleotide binding]; other site 768670004436 dimer interface [polypeptide binding]; other site 768670004437 hypothetical protein; Validated; Region: PRK00110 768670004438 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 768670004439 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 768670004440 Cupin domain; Region: Cupin_2; pfam07883 768670004441 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 768670004442 active site 768670004443 multimer interface [polypeptide binding]; other site 768670004444 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 768670004445 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 768670004446 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768670004447 catalytic residue [active] 768670004448 Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547 768670004449 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 768670004450 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 768670004451 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 768670004452 Preprotein translocase subunit; Region: YajC; pfam02699 768670004453 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 768670004454 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 768670004455 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 768670004456 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 768670004457 Protein export membrane protein; Region: SecD_SecF; pfam02355 768670004458 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 768670004459 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 768670004460 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 768670004461 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 768670004462 tartrate dehydrogenase; Region: TTC; TIGR02089 768670004463 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 768670004464 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 768670004465 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768670004466 active site 768670004467 phosphorylation site [posttranslational modification] 768670004468 intermolecular recognition site; other site 768670004469 dimerization interface [polypeptide binding]; other site 768670004470 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768670004471 Walker A motif; other site 768670004472 ATP binding site [chemical binding]; other site 768670004473 Walker B motif; other site 768670004474 arginine finger; other site 768670004475 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 768670004476 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 768670004477 dimerization interface [polypeptide binding]; other site 768670004478 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768670004479 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768670004480 phosphorylation site [posttranslational modification] 768670004481 dimer interface [polypeptide binding]; other site 768670004482 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768670004483 ATP binding site [chemical binding]; other site 768670004484 Mg2+ binding site [ion binding]; other site 768670004485 G-X-G motif; other site 768670004486 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cd00296 768670004487 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 768670004488 nucleoside/Zn binding site; other site 768670004489 dimer interface [polypeptide binding]; other site 768670004490 catalytic motif [active] 768670004491 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 768670004492 RNA methyltransferase, RsmE family; Region: TIGR00046 768670004493 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 768670004494 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768670004495 S-adenosylmethionine binding site [chemical binding]; other site 768670004496 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 768670004497 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 768670004498 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 768670004499 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 768670004500 active site 768670004501 (T/H)XGH motif; other site 768670004502 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 768670004503 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 768670004504 putative catalytic cysteine [active] 768670004505 gamma-glutamyl kinase; Provisional; Region: PRK05429 768670004506 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 768670004507 nucleotide binding site [chemical binding]; other site 768670004508 homotetrameric interface [polypeptide binding]; other site 768670004509 putative phosphate binding site [ion binding]; other site 768670004510 putative allosteric binding site; other site 768670004511 PUA domain; Region: PUA; pfam01472 768670004512 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 768670004513 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 768670004514 putative active site [active] 768670004515 putative metal binding site [ion binding]; other site 768670004516 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 768670004517 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 768670004518 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 768670004519 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 768670004520 succinate dehydrogenase, flavoprotein subunit, E. coli/mitochondrial subgroup; Region: sdhA_forward; TIGR01816 768670004521 L-aspartate oxidase; Provisional; Region: PRK06175 768670004522 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 768670004523 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 768670004524 Iron-sulfur protein interface; other site 768670004525 proximal heme binding site [chemical binding]; other site 768670004526 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 768670004527 Iron-sulfur protein interface; other site 768670004528 proximal heme binding site [chemical binding]; other site 768670004529 tellurite resistance protein TehB; Provisional; Region: PRK12335 768670004530 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 768670004531 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 768670004532 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 768670004533 HSP70 interaction site [polypeptide binding]; other site 768670004534 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768670004535 binding surface 768670004536 TPR motif; other site 768670004537 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 768670004538 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 768670004539 active site 768670004540 dimerization interface [polypeptide binding]; other site 768670004541 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 768670004542 Saccharomyces cerevisiae (Sc) citrate synthase (CS)-like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) with oxaloacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). Some CS...; Region: ScCS-like; cd06103 768670004543 citrate (Si)-synthase, eukaryotic; Region: cit_synth_euk; TIGR01793 768670004544 dimer interface [polypeptide binding]; other site 768670004545 active site 768670004546 coenzyme A binding site [chemical binding]; other site 768670004547 citrylCoA binding site [chemical binding]; other site 768670004548 oxalacetate/citrate binding site [chemical binding]; other site 768670004549 catalytic triad [active] 768670004550 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 768670004551 EamA-like transporter family; Region: EamA; pfam00892 768670004552 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 768670004553 substrate binding site [chemical binding]; other site 768670004554 oxyanion hole (OAH) forming residues; other site 768670004555 trimer interface [polypeptide binding]; other site 768670004556 DNA polymerase I; Provisional; Region: PRK05755 768670004557 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 768670004558 active site 768670004559 metal binding site 1 [ion binding]; metal-binding site 768670004560 putative 5' ssDNA interaction site; other site 768670004561 metal binding site 3; metal-binding site 768670004562 metal binding site 2 [ion binding]; metal-binding site 768670004563 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 768670004564 putative DNA binding site [nucleotide binding]; other site 768670004565 putative metal binding site [ion binding]; other site 768670004566 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 768670004567 active site 768670004568 DNA binding site [nucleotide binding] 768670004569 catalytic site [active] 768670004570 GAF domain; Region: GAF_2; pfam13185 768670004571 GAF domain; Region: GAF_3; pfam13492 768670004572 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768670004573 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 768670004574 metal binding site [ion binding]; metal-binding site 768670004575 active site 768670004576 I-site; other site 768670004577 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 768670004578 histidinol dehydrogenase; Region: hisD; TIGR00069 768670004579 NAD binding site [chemical binding]; other site 768670004580 dimerization interface [polypeptide binding]; other site 768670004581 product binding site; other site 768670004582 substrate binding site [chemical binding]; other site 768670004583 zinc binding site [ion binding]; other site 768670004584 catalytic residues [active] 768670004585 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 768670004586 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 768670004587 substrate binding site [chemical binding]; other site 768670004588 hexamer interface [polypeptide binding]; other site 768670004589 metal binding site [ion binding]; metal-binding site 768670004590 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 768670004591 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768670004592 S-adenosylmethionine binding site [chemical binding]; other site 768670004593 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768670004594 active site 768670004595 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 768670004596 phosphorylation site [posttranslational modification] 768670004597 intermolecular recognition site; other site 768670004598 dimerization interface [polypeptide binding]; other site 768670004599 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768670004600 active site 768670004601 phosphorylation site [posttranslational modification] 768670004602 intermolecular recognition site; other site 768670004603 dimerization interface [polypeptide binding]; other site 768670004604 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768670004605 metal binding site [ion binding]; metal-binding site 768670004606 active site 768670004607 I-site; other site 768670004608 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 768670004609 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 768670004610 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cd00596 768670004611 active site 768670004612 Zn binding site [ion binding]; other site 768670004613 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 768670004614 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 768670004615 putative ligand binding site [chemical binding]; other site 768670004616 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 768670004617 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 768670004618 Walker A/P-loop; other site 768670004619 ATP binding site [chemical binding]; other site 768670004620 Q-loop/lid; other site 768670004621 ABC transporter signature motif; other site 768670004622 Walker B; other site 768670004623 D-loop; other site 768670004624 H-loop/switch region; other site 768670004625 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 768670004626 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768670004627 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 768670004628 TM-ABC transporter signature motif; other site 768670004629 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768670004630 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 768670004631 TM-ABC transporter signature motif; other site 768670004632 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 768670004633 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768670004634 active site 768670004635 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768670004636 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768670004637 dimerization interface [polypeptide binding]; other site 768670004638 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768670004639 dimer interface [polypeptide binding]; other site 768670004640 phosphorylation site [posttranslational modification] 768670004641 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768670004642 ATP binding site [chemical binding]; other site 768670004643 Mg2+ binding site [ion binding]; other site 768670004644 G-X-G motif; other site 768670004645 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 768670004646 Ligand binding site; other site 768670004647 Putative Catalytic site; other site 768670004648 DXD motif; other site 768670004649 Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627 768670004650 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 768670004651 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 768670004652 PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major...; Region: PAP2_lipid_A_1_phosphatase; cd03389 768670004653 active site 768670004654 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 768670004655 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 768670004656 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 768670004657 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 768670004658 RNase E interface [polypeptide binding]; other site 768670004659 trimer interface [polypeptide binding]; other site 768670004660 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 768670004661 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 768670004662 RNase E interface [polypeptide binding]; other site 768670004663 trimer interface [polypeptide binding]; other site 768670004664 active site 768670004665 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 768670004666 putative nucleic acid binding region [nucleotide binding]; other site 768670004667 G-X-X-G motif; other site 768670004668 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 768670004669 RNA binding site [nucleotide binding]; other site 768670004670 domain interface; other site 768670004671 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 768670004672 16S/18S rRNA binding site [nucleotide binding]; other site 768670004673 S13e-L30e interaction site [polypeptide binding]; other site 768670004674 25S rRNA binding site [nucleotide binding]; other site 768670004675 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 768670004676 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 768670004677 RNA binding site [nucleotide binding]; other site 768670004678 active site 768670004679 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 768670004680 Protein of unknown function (DUF503); Region: DUF503; pfam04456 768670004681 translation initiation factor IF-2; Region: IF-2; TIGR00487 768670004682 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 768670004683 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 768670004684 G1 box; other site 768670004685 putative GEF interaction site [polypeptide binding]; other site 768670004686 GTP/Mg2+ binding site [chemical binding]; other site 768670004687 Switch I region; other site 768670004688 G2 box; other site 768670004689 G3 box; other site 768670004690 Switch II region; other site 768670004691 G4 box; other site 768670004692 G5 box; other site 768670004693 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 768670004694 Translation-initiation factor 2; Region: IF-2; pfam11987 768670004695 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 768670004696 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 768670004697 NusA N-terminal domain; Region: NusA_N; pfam08529 768670004698 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 768670004699 RNA binding site [nucleotide binding]; other site 768670004700 homodimer interface [polypeptide binding]; other site 768670004701 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 768670004702 G-X-X-G motif; other site 768670004703 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 768670004704 G-X-X-G motif; other site 768670004705 ribosome maturation protein RimP; Reviewed; Region: PRK00092 768670004706 Sm and related proteins; Region: Sm_like; cl00259 768670004707 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 768670004708 putative oligomer interface [polypeptide binding]; other site 768670004709 putative RNA binding site [nucleotide binding]; other site 768670004710 triosephosphate isomerase; Provisional; Region: PRK14567 768670004711 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 768670004712 substrate binding site [chemical binding]; other site 768670004713 dimer interface [polypeptide binding]; other site 768670004714 catalytic triad [active] 768670004715 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 768670004716 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 768670004717 ParB-like nuclease domain; Region: ParB; smart00470 768670004718 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 768670004719 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 768670004720 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 768670004721 P-loop; other site 768670004722 Magnesium ion binding site [ion binding]; other site 768670004723 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 768670004724 Magnesium ion binding site [ion binding]; other site 768670004725 Predicted methyltransferases [General function prediction only]; Region: COG0313 768670004726 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 768670004727 putative SAM binding site [chemical binding]; other site 768670004728 putative homodimer interface [polypeptide binding]; other site 768670004729 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 768670004730 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768670004731 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768670004732 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 768670004733 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 768670004734 dimerization interface [polypeptide binding]; other site 768670004735 active site 768670004736 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 768670004737 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 768670004738 HIGH motif; other site 768670004739 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 768670004740 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 768670004741 active site 768670004742 KMSKS motif; other site 768670004743 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 768670004744 tRNA binding surface [nucleotide binding]; other site 768670004745 anticodon binding site; other site 768670004746 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 768670004747 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 768670004748 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 768670004749 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 768670004750 putative substrate binding site [chemical binding]; other site 768670004751 putative ATP binding site [chemical binding]; other site 768670004752 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 768670004753 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 768670004754 putative ribose interaction site [chemical binding]; other site 768670004755 putative ADP binding site [chemical binding]; other site 768670004756 Uncharacterized conserved protein [Function unknown]; Region: COG2835 768670004757 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 768670004758 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 768670004759 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 768670004760 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 768670004761 putative active site [active] 768670004762 catalytic site [active] 768670004763 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 768670004764 putative active site [active] 768670004765 catalytic site [active] 768670004766 EamA-like transporter family; Region: EamA; pfam00892 768670004767 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 768670004768 EamA-like transporter family; Region: EamA; pfam00892 768670004769 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 768670004770 23S rRNA binding site [nucleotide binding]; other site 768670004771 L21 binding site [polypeptide binding]; other site 768670004772 L13 binding site [polypeptide binding]; other site 768670004773 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 768670004774 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 768670004775 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 768670004776 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 768670004777 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 768670004778 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 768670004779 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 768670004780 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 768670004781 active site 768670004782 dimer interface [polypeptide binding]; other site 768670004783 motif 1; other site 768670004784 motif 2; other site 768670004785 motif 3; other site 768670004786 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 768670004787 anticodon binding site; other site 768670004788 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 768670004789 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 768670004790 substrate binding site [chemical binding]; other site 768670004791 oxyanion hole (OAH) forming residues; other site 768670004792 trimer interface [polypeptide binding]; other site 768670004793 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 768670004794 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 768670004795 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 768670004796 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 768670004797 HlyD family secretion protein; Region: HlyD_3; pfam13437 768670004798 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 768670004799 Protein export membrane protein; Region: SecD_SecF; cl14618 768670004800 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 768670004801 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 768670004802 flagellar motor switch protein FliN; Region: fliN; TIGR02480 768670004803 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 768670004804 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768670004805 TPR motif; other site 768670004806 binding surface 768670004807 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768670004808 dimer interface [polypeptide binding]; other site 768670004809 phosphorylation site [posttranslational modification] 768670004810 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 768670004811 RNA/DNA hybrid binding site [nucleotide binding]; other site 768670004812 active site 768670004813 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 768670004814 Putative zinc ribbon domain; Region: DUF164; pfam02591 768670004815 Uncharacterized conserved protein [Function unknown]; Region: COG0327 768670004816 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 768670004817 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 768670004818 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 768670004819 Uncharacterized conserved protein [Function unknown]; Region: COG0327 768670004820 MarC family integral membrane protein; Region: MarC; cl00919 768670004821 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 768670004822 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 768670004823 Tetramer interface [polypeptide binding]; other site 768670004824 active site 768670004825 FMN-binding site [chemical binding]; other site 768670004826 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 768670004827 Oxidoreductase molybdopterin binding domain; Region: Oxidored_molyb; pfam00174 768670004828 Moco binding site; other site 768670004829 metal coordination site [ion binding]; other site 768670004830 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 768670004831 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 768670004832 FAD binding domain; Region: FAD_binding_4; pfam01565 768670004833 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 768670004834 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 768670004835 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 768670004836 Cysteine-rich domain; Region: CCG; pfam02754 768670004837 Cysteine-rich domain; Region: CCG; pfam02754 768670004838 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 768670004839 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 768670004840 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 768670004841 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 768670004842 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768670004843 PAS domain; Region: PAS_9; pfam13426 768670004844 putative active site [active] 768670004845 heme pocket [chemical binding]; other site 768670004846 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 768670004847 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768670004848 Walker A motif; other site 768670004849 ATP binding site [chemical binding]; other site 768670004850 Walker B motif; other site 768670004851 arginine finger; other site 768670004852 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 768670004853 DNA binding residues [nucleotide binding] 768670004854 putative acyltransferase; Provisional; Region: PRK05790 768670004855 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 768670004856 dimer interface [polypeptide binding]; other site 768670004857 active site 768670004858 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 768670004859 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 768670004860 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 768670004861 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 768670004862 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768670004863 NAD(P) binding site [chemical binding]; other site 768670004864 active site 768670004865 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 768670004866 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 768670004867 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768670004868 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768670004869 ATP binding site [chemical binding]; other site 768670004870 Mg2+ binding site [ion binding]; other site 768670004871 G-X-G motif; other site 768670004872 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 768670004873 active site 768670004874 Sporulation related domain; Region: SPOR; pfam05036 768670004875 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 768670004876 NlpC/P60 family; Region: NLPC_P60; pfam00877 768670004877 DEDDy 3'-5' exonuclease domain of WRN and similar proteins; Region: WRN_exo; cd06141 768670004878 catalytic site [active] 768670004879 putative active site [active] 768670004880 putative substrate binding site [chemical binding]; other site 768670004881 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 768670004882 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 768670004883 N-acetyl-D-glucosamine binding site [chemical binding]; other site 768670004884 catalytic residue [active] 768670004885 futalosine nucleosidase; Region: fut_nucase; TIGR03664 768670004886 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 768670004887 FAD binding site [chemical binding]; other site 768670004888 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 768670004889 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 768670004890 N-acetyl-D-glucosamine binding site [chemical binding]; other site 768670004891 catalytic residue [active] 768670004892 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 768670004893 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 768670004894 active site 768670004895 NAD binding site [chemical binding]; other site 768670004896 metal binding site [ion binding]; metal-binding site 768670004897 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 768670004898 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 768670004899 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 768670004900 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 768670004901 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 768670004902 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 768670004903 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 768670004904 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768670004905 DNA binding residues [nucleotide binding] 768670004906 DNA primase, catalytic core; Region: dnaG; TIGR01391 768670004907 CHC2 zinc finger; Region: zf-CHC2; pfam01807 768670004908 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 768670004909 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 768670004910 active site 768670004911 metal binding site [ion binding]; metal-binding site 768670004912 interdomain interaction site; other site 768670004913 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 768670004914 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 768670004915 Walker A/P-loop; other site 768670004916 ATP binding site [chemical binding]; other site 768670004917 Q-loop/lid; other site 768670004918 ABC transporter signature motif; other site 768670004919 Walker B; other site 768670004920 D-loop; other site 768670004921 H-loop/switch region; other site 768670004922 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 768670004923 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 768670004924 AAA domain; Region: AAA_26; pfam13500 768670004925 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 768670004926 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768670004927 Walker A motif; other site 768670004928 ATP binding site [chemical binding]; other site 768670004929 Walker B motif; other site 768670004930 arginine finger; other site 768670004931 hypothetical protein; Validated; Region: PRK00153 768670004932 recombination protein RecR; Reviewed; Region: recR; PRK00076 768670004933 RecR protein; Region: RecR; pfam02132 768670004934 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 768670004935 putative active site [active] 768670004936 putative metal-binding site [ion binding]; other site 768670004937 tetramer interface [polypeptide binding]; other site 768670004938 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 768670004939 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 768670004940 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 768670004941 G1 box; other site 768670004942 GTP/Mg2+ binding site [chemical binding]; other site 768670004943 G2 box; other site 768670004944 Switch I region; other site 768670004945 G3 box; other site 768670004946 Switch II region; other site 768670004947 G4 box; other site 768670004948 G5 box; other site 768670004949 ribonuclease G; Provisional; Region: PRK11712 768670004950 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 768670004951 homodimer interface [polypeptide binding]; other site 768670004952 oligonucleotide binding site [chemical binding]; other site 768670004953 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 768670004954 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768670004955 S-adenosylmethionine binding site [chemical binding]; other site 768670004956 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 768670004957 AIR carboxylase; Region: AIRC; smart01001 768670004958 Uncharacterized ArCR, COG2043; Region: DUF169; pfam02596 768670004959 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 768670004960 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 768670004961 active site 768670004962 substrate binding site [chemical binding]; other site 768670004963 metal binding site [ion binding]; metal-binding site 768670004964 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 768670004965 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 768670004966 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768670004967 metal binding site [ion binding]; metal-binding site 768670004968 active site 768670004969 I-site; other site 768670004970 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 768670004971 endonuclease IV; Provisional; Region: PRK01060 768670004972 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 768670004973 AP (apurinic/apyrimidinic) site pocket; other site 768670004974 DNA interaction; other site 768670004975 Metal-binding active site; metal-binding site 768670004976 fructose-1,6-bisphosphatase family protein; Region: PLN02628 768670004977 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 768670004978 AMP binding site [chemical binding]; other site 768670004979 metal binding site [ion binding]; metal-binding site 768670004980 active site 768670004981 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 768670004982 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 768670004983 N-acetyl-D-glucosamine binding site [chemical binding]; other site 768670004984 catalytic residue [active] 768670004985 LPP20 lipoprotein; Region: LPP20; pfam02169 768670004986 FecR protein; Region: FecR; pfam04773 768670004987 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 768670004988 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 768670004989 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 768670004990 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 768670004991 Zn2+ binding site [ion binding]; other site 768670004992 Mg2+ binding site [ion binding]; other site 768670004993 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 768670004994 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 768670004995 Cl- selectivity filter; other site 768670004996 Cl- binding residues [ion binding]; other site 768670004997 pore gating glutamate residue; other site 768670004998 dimer interface [polypeptide binding]; other site 768670004999 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 768670005000 FOG: CBS domain [General function prediction only]; Region: COG0517 768670005001 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613 768670005002 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 768670005003 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 768670005004 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768670005005 Walker A/P-loop; other site 768670005006 ATP binding site [chemical binding]; other site 768670005007 Q-loop/lid; other site 768670005008 ABC transporter signature motif; other site 768670005009 Walker B; other site 768670005010 D-loop; other site 768670005011 H-loop/switch region; other site 768670005012 Methyltransferase domain; Region: Methyltransf_31; pfam13847 768670005013 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768670005014 S-adenosylmethionine binding site [chemical binding]; other site 768670005015 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 768670005016 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 768670005017 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 768670005018 TrkA-N domain; Region: TrkA_N; pfam02254 768670005019 TrkA-C domain; Region: TrkA_C; pfam02080 768670005020 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 768670005021 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 768670005022 AAA domain; Region: AAA_14; pfam13173 768670005023 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 768670005024 Nuclease-related domain; Region: NERD; pfam08378 768670005025 Virulence protein [General function prediction only]; Region: COG3943 768670005026 SIR2-like domain; Region: SIR2_2; pfam13289 768670005027 Piwi-like: PIWI domain. Domain found in proteins involved in RNA silencing. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs. The...; Region: Piwi-like; cl00628 768670005028 5' RNA guide strand anchoring site; other site 768670005029 active site 768670005030 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 768670005031 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768670005032 S-adenosylmethionine binding site [chemical binding]; other site 768670005033 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 768670005034 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 768670005035 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 768670005036 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 768670005037 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 768670005038 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768670005039 ATP binding site [chemical binding]; other site 768670005040 putative Mg++ binding site [ion binding]; other site 768670005041 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 768670005042 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 768670005043 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 768670005044 ABC1 family; Region: ABC1; cl17513 768670005045 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 768670005046 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 768670005047 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 768670005048 Bacitracin resistance protein BacA; Region: BacA; pfam02673 768670005049 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 768670005050 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 768670005051 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 768670005052 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 768670005053 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 768670005054 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 768670005055 GIY-YIG motif/motif A; other site 768670005056 active site 768670005057 catalytic site [active] 768670005058 putative DNA binding site [nucleotide binding]; other site 768670005059 metal binding site [ion binding]; metal-binding site 768670005060 UvrB/uvrC motif; Region: UVR; pfam02151 768670005061 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 768670005062 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 768670005063 classical (c) SDRs; Region: SDR_c; cd05233 768670005064 NAD(P) binding site [chemical binding]; other site 768670005065 active site 768670005066 elongation factor Ts; Provisional; Region: tsf; PRK09377 768670005067 UBA/TS-N domain; Region: UBA; pfam00627 768670005068 Elongation factor TS; Region: EF_TS; pfam00889 768670005069 Elongation factor TS; Region: EF_TS; pfam00889 768670005070 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 768670005071 rRNA interaction site [nucleotide binding]; other site 768670005072 S8 interaction site; other site 768670005073 putative laminin-1 binding site; other site 768670005074 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 768670005075 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 768670005076 Staphylococcal nuclease homologues; Region: SNc; smart00318 768670005077 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 768670005078 Catalytic site; other site 768670005079 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 768670005080 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 768670005081 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 768670005082 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 768670005083 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 768670005084 dimerization domain swap beta strand [polypeptide binding]; other site 768670005085 regulatory protein interface [polypeptide binding]; other site 768670005086 active site 768670005087 regulatory phosphorylation site [posttranslational modification]; other site 768670005088 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 768670005089 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 768670005090 active site 768670005091 phosphorylation site [posttranslational modification] 768670005092 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 768670005093 active pocket/dimerization site; other site 768670005094 active site 768670005095 phosphorylation site [posttranslational modification] 768670005096 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 768670005097 shikimate kinase; Reviewed; Region: aroK; PRK00131 768670005098 HPr kinase/phosphorylase; Provisional; Region: PRK05428 768670005099 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 768670005100 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 768670005101 Hpr binding site; other site 768670005102 active site 768670005103 homohexamer subunit interaction site [polypeptide binding]; other site 768670005104 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 768670005105 active site 768670005106 phosphorylation site [posttranslational modification] 768670005107 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 768670005108 30S subunit binding site; other site 768670005109 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 768670005110 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 768670005111 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 768670005112 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 768670005113 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 768670005114 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 768670005115 Walker A/P-loop; other site 768670005116 ATP binding site [chemical binding]; other site 768670005117 Q-loop/lid; other site 768670005118 ABC transporter signature motif; other site 768670005119 Walker B; other site 768670005120 D-loop; other site 768670005121 H-loop/switch region; other site 768670005122 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 768670005123 OstA-like protein; Region: OstA; pfam03968 768670005124 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 768670005125 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 768670005126 active site 768670005127 motif I; other site 768670005128 motif II; other site 768670005129 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 768670005130 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 768670005131 putative active site [active] 768670005132 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 768670005133 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 768670005134 CTP synthetase; Validated; Region: pyrG; PRK05380 768670005135 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 768670005136 Catalytic site [active] 768670005137 active site 768670005138 UTP binding site [chemical binding]; other site 768670005139 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 768670005140 active site 768670005141 putative oxyanion hole; other site 768670005142 catalytic triad [active] 768670005143 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 768670005144 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 768670005145 Ligand binding site; other site 768670005146 oligomer interface; other site 768670005147 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 768670005148 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 768670005149 active site 768670005150 hydrophilic channel; other site 768670005151 dimerization interface [polypeptide binding]; other site 768670005152 catalytic residues [active] 768670005153 active site lid [active] 768670005154 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314 768670005155 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 768670005156 active site 768670005157 substrate binding site [chemical binding]; other site 768670005158 metal binding site [ion binding]; metal-binding site 768670005159 YbbR-like protein; Region: YbbR; pfam07949 768670005160 YbbR-like protein; Region: YbbR; pfam07949 768670005161 TIGR00159 family protein; Region: TIGR00159 768670005162 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 768670005163 dihydropteroate synthase; Region: DHPS; TIGR01496 768670005164 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 768670005165 substrate binding pocket [chemical binding]; other site 768670005166 dimer interface [polypeptide binding]; other site 768670005167 inhibitor binding site; inhibition site 768670005168 FtsH Extracellular; Region: FtsH_ext; pfam06480 768670005169 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 768670005170 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768670005171 Walker A motif; other site 768670005172 ATP binding site [chemical binding]; other site 768670005173 Walker B motif; other site 768670005174 arginine finger; other site 768670005175 Peptidase family M41; Region: Peptidase_M41; pfam01434 768670005176 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768670005177 active site 768670005178 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 768670005179 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 768670005180 Ligand Binding Site [chemical binding]; other site 768670005181 glucose-6-phosphate isomerase; Provisional; Region: PRK00973 768670005182 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 768670005183 dimer interface [polypeptide binding]; other site 768670005184 active site 768670005185 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 768670005186 dimer interface [polypeptide binding]; other site 768670005187 active site 768670005188 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 768670005189 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768670005190 ATP binding site [chemical binding]; other site 768670005191 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 768670005192 putative Mg++ binding site [ion binding]; other site 768670005193 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 768670005194 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 768670005195 pilus retraction protein PilT; Region: pilT_fam; TIGR01420 768670005196 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 768670005197 Walker A motif; other site 768670005198 ATP binding site [chemical binding]; other site 768670005199 Walker B motif; other site 768670005200 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 768670005201 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 768670005202 putative active site; other site 768670005203 catalytic triad [active] 768670005204 putative dimer interface [polypeptide binding]; other site 768670005205 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 768670005206 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 768670005207 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 768670005208 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 768670005209 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 768670005210 active site 768670005211 HIGH motif; other site 768670005212 KMSK motif region; other site 768670005213 tRNA binding surface [nucleotide binding]; other site 768670005214 DALR anticodon binding domain; Region: DALR_1; smart00836 768670005215 anticodon binding site; other site 768670005216 Mechanosensitive ion channel; Region: MS_channel; pfam00924 768670005217 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 768670005218 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 768670005219 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 768670005220 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 768670005221 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 768670005222 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 768670005223 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 768670005224 lipid-A-disaccharide synthase; Region: lpxB; TIGR00215 768670005225 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 768670005226 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 768670005227 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 768670005228 Pilus assembly protein, PilP; Region: PilP; pfam04351 768670005229 Pilus assembly protein, PilO; Region: PilO; cl01234 768670005230 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 768670005231 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 768670005232 Cell division protein FtsA; Region: FtsA; cl17206 768670005233 Competence protein A; Region: Competence_A; pfam11104 768670005234 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 768670005235 Cytochrome c; Region: Cytochrom_C; cl11414 768670005236 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 768670005237 dimerization interface [polypeptide binding]; other site 768670005238 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 768670005239 ATP binding site [chemical binding]; other site 768670005240 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 768670005241 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 768670005242 HupF/HypC family; Region: HupF_HypC; pfam01455 768670005243 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 768670005244 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 768670005245 heme-binding residues [chemical binding]; other site 768670005246 ATP synthase subunit C; Region: ATP-synt_C; cl00466 768670005247 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 768670005248 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 768670005249 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 768670005250 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 768670005251 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 768670005252 inhibitor-cofactor binding pocket; inhibition site 768670005253 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768670005254 catalytic residue [active] 768670005255 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 768670005256 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768670005257 Walker A/P-loop; other site 768670005258 ATP binding site [chemical binding]; other site 768670005259 Q-loop/lid; other site 768670005260 ABC transporter signature motif; other site 768670005261 Walker B; other site 768670005262 D-loop; other site 768670005263 H-loop/switch region; other site 768670005264 ABC transporter; Region: ABC_tran_2; pfam12848 768670005265 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 768670005266 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 768670005267 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 768670005268 Metal-binding active site; metal-binding site 768670005269 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 768670005270 intersubunit interface [polypeptide binding]; other site 768670005271 active site 768670005272 Zn2+ binding site [ion binding]; other site 768670005273 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 768670005274 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 768670005275 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 768670005276 alphaNTD - beta interaction site [polypeptide binding]; other site 768670005277 alphaNTD homodimer interface [polypeptide binding]; other site 768670005278 alphaNTD - beta' interaction site [polypeptide binding]; other site 768670005279 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 768670005280 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 768670005281 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 768670005282 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768670005283 RNA binding surface [nucleotide binding]; other site 768670005284 30S ribosomal protein S11; Validated; Region: PRK05309 768670005285 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 768670005286 30S ribosomal protein S13; Region: bact_S13; TIGR03631 768670005287 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 768670005288 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 768670005289 rRNA binding site [nucleotide binding]; other site 768670005290 predicted 30S ribosome binding site; other site 768670005291 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 768670005292 active site 768670005293 adenylate kinase; Reviewed; Region: adk; PRK00279 768670005294 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 768670005295 AMP-binding site [chemical binding]; other site 768670005296 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 768670005297 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 768670005298 SecY translocase; Region: SecY; pfam00344 768670005299 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 768670005300 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 768670005301 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 768670005302 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 768670005303 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 768670005304 5S rRNA interface [nucleotide binding]; other site 768670005305 L27 interface [polypeptide binding]; other site 768670005306 23S rRNA interface [nucleotide binding]; other site 768670005307 L5 interface [polypeptide binding]; other site 768670005308 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 768670005309 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 768670005310 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 768670005311 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 768670005312 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 768670005313 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 768670005314 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 768670005315 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 768670005316 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 768670005317 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 768670005318 RNA binding site [nucleotide binding]; other site 768670005319 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 768670005320 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 768670005321 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 768670005322 23S rRNA interface [nucleotide binding]; other site 768670005323 putative translocon interaction site; other site 768670005324 signal recognition particle (SRP54) interaction site; other site 768670005325 L23 interface [polypeptide binding]; other site 768670005326 trigger factor interaction site; other site 768670005327 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 768670005328 23S rRNA interface [nucleotide binding]; other site 768670005329 5S rRNA interface [nucleotide binding]; other site 768670005330 putative antibiotic binding site [chemical binding]; other site 768670005331 L25 interface [polypeptide binding]; other site 768670005332 L27 interface [polypeptide binding]; other site 768670005333 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 768670005334 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 768670005335 G-X-X-G motif; other site 768670005336 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 768670005337 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 768670005338 putative translocon binding site; other site 768670005339 protein-rRNA interface [nucleotide binding]; other site 768670005340 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 768670005341 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 768670005342 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 768670005343 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 768670005344 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 768670005345 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 768670005346 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 768670005347 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 768670005348 elongation factor Tu; Reviewed; Region: PRK00049 768670005349 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 768670005350 G1 box; other site 768670005351 GEF interaction site [polypeptide binding]; other site 768670005352 GTP/Mg2+ binding site [chemical binding]; other site 768670005353 Switch I region; other site 768670005354 G2 box; other site 768670005355 G3 box; other site 768670005356 Switch II region; other site 768670005357 G4 box; other site 768670005358 G5 box; other site 768670005359 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 768670005360 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 768670005361 Antibiotic Binding Site [chemical binding]; other site 768670005362 elongation factor G; Reviewed; Region: PRK00007 768670005363 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 768670005364 G1 box; other site 768670005365 putative GEF interaction site [polypeptide binding]; other site 768670005366 GTP/Mg2+ binding site [chemical binding]; other site 768670005367 Switch I region; other site 768670005368 G2 box; other site 768670005369 G3 box; other site 768670005370 Switch II region; other site 768670005371 G4 box; other site 768670005372 G5 box; other site 768670005373 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 768670005374 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 768670005375 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 768670005376 30S ribosomal protein S7; Validated; Region: PRK05302 768670005377 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 768670005378 S17 interaction site [polypeptide binding]; other site 768670005379 S8 interaction site; other site 768670005380 16S rRNA interaction site [nucleotide binding]; other site 768670005381 streptomycin interaction site [chemical binding]; other site 768670005382 23S rRNA interaction site [nucleotide binding]; other site 768670005383 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 768670005384 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cl03439 768670005385 heme-binding residues [chemical binding]; other site 768670005386 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 768670005387 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768670005388 FeS/SAM binding site; other site 768670005389 HemN C-terminal domain; Region: HemN_C; pfam06969 768670005390 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 768670005391 biotin synthase; Region: bioB; TIGR00433 768670005392 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768670005393 FeS/SAM binding site; other site 768670005394 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 768670005395 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 768670005396 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768670005397 Walker A motif; other site 768670005398 ATP binding site [chemical binding]; other site 768670005399 Walker B motif; other site 768670005400 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 768670005401 Walker B motif; other site 768670005402 arginine finger; other site 768670005403 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 768670005404 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 768670005405 active site 768670005406 HslU subunit interaction site [polypeptide binding]; other site 768670005407 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 768670005408 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 768670005409 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 768670005410 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 768670005411 Walker A/P-loop; other site 768670005412 ATP binding site [chemical binding]; other site 768670005413 Q-loop/lid; other site 768670005414 ABC transporter signature motif; other site 768670005415 Walker B; other site 768670005416 D-loop; other site 768670005417 H-loop/switch region; other site 768670005418 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768670005419 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 768670005420 dimer interface [polypeptide binding]; other site 768670005421 conserved gate region; other site 768670005422 putative PBP binding loops; other site 768670005423 ABC-ATPase subunit interface; other site 768670005424 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 768670005425 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 768670005426 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 768670005427 dimerization interface [polypeptide binding]; other site 768670005428 active site 768670005429 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 768670005430 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 768670005431 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 768670005432 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 768670005433 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 768670005434 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 768670005435 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 768670005436 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 768670005437 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 768670005438 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 768670005439 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 768670005440 DNA binding site [nucleotide binding] 768670005441 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 768670005442 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 768670005443 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 768670005444 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 768670005445 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 768670005446 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 768670005447 RPB12 interaction site [polypeptide binding]; other site 768670005448 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 768670005449 RPB3 interaction site [polypeptide binding]; other site 768670005450 RPB1 interaction site [polypeptide binding]; other site 768670005451 RPB11 interaction site [polypeptide binding]; other site 768670005452 RPB10 interaction site [polypeptide binding]; other site 768670005453 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 768670005454 core dimer interface [polypeptide binding]; other site 768670005455 peripheral dimer interface [polypeptide binding]; other site 768670005456 L10 interface [polypeptide binding]; other site 768670005457 L11 interface [polypeptide binding]; other site 768670005458 putative EF-Tu interaction site [polypeptide binding]; other site 768670005459 putative EF-G interaction site [polypeptide binding]; other site 768670005460 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 768670005461 23S rRNA interface [nucleotide binding]; other site 768670005462 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 768670005463 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 768670005464 mRNA/rRNA interface [nucleotide binding]; other site 768670005465 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 768670005466 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 768670005467 23S rRNA interface [nucleotide binding]; other site 768670005468 L7/L12 interface [polypeptide binding]; other site 768670005469 putative thiostrepton binding site; other site 768670005470 L25 interface [polypeptide binding]; other site 768670005471 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 768670005472 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 768670005473 putative homodimer interface [polypeptide binding]; other site 768670005474 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 768670005475 heterodimer interface [polypeptide binding]; other site 768670005476 homodimer interface [polypeptide binding]; other site 768670005477 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 768670005478 elongation factor Tu; Reviewed; Region: PRK00049 768670005479 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 768670005480 G1 box; other site 768670005481 GEF interaction site [polypeptide binding]; other site 768670005482 GTP/Mg2+ binding site [chemical binding]; other site 768670005483 Switch I region; other site 768670005484 G2 box; other site 768670005485 G3 box; other site 768670005486 Switch II region; other site 768670005487 G4 box; other site 768670005488 G5 box; other site 768670005489 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 768670005490 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 768670005491 Antibiotic Binding Site [chemical binding]; other site 768670005492 Response regulator receiver domain; Region: Response_reg; pfam00072 768670005493 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768670005494 active site 768670005495 phosphorylation site [posttranslational modification] 768670005496 intermolecular recognition site; other site 768670005497 dimerization interface [polypeptide binding]; other site 768670005498 bacterial Hfq-like; Region: Hfq; cd01716 768670005499 hexamer interface [polypeptide binding]; other site 768670005500 Sm1 motif; other site 768670005501 RNA binding site [nucleotide binding]; other site 768670005502 Sm2 motif; other site 768670005503 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768670005504 dimerization interface [polypeptide binding]; other site 768670005505 putative DNA binding site [nucleotide binding]; other site 768670005506 putative Zn2+ binding site [ion binding]; other site 768670005507 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 768670005508 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768670005509 NAD(P) binding site [chemical binding]; other site 768670005510 active site 768670005511 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 768670005512 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 768670005513 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 768670005514 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768670005515 catalytic residue [active] 768670005516 Protein of unknown function DUF72; Region: DUF72; pfam01904 768670005517 PAS domain; Region: PAS; smart00091 768670005518 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768670005519 PAS domain; Region: PAS_9; pfam13426 768670005520 putative active site [active] 768670005521 heme pocket [chemical binding]; other site 768670005522 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768670005523 metal binding site [ion binding]; metal-binding site 768670005524 active site 768670005525 I-site; other site 768670005526 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 768670005527 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 768670005528 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 768670005529 PAS domain S-box; Region: sensory_box; TIGR00229 768670005530 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768670005531 putative active site [active] 768670005532 heme pocket [chemical binding]; other site 768670005533 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768670005534 dimer interface [polypeptide binding]; other site 768670005535 phosphorylation site [posttranslational modification] 768670005536 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768670005537 ATP binding site [chemical binding]; other site 768670005538 Mg2+ binding site [ion binding]; other site 768670005539 G-X-G motif; other site 768670005540 Response regulator receiver domain; Region: Response_reg; pfam00072 768670005541 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768670005542 active site 768670005543 phosphorylation site [posttranslational modification] 768670005544 intermolecular recognition site; other site 768670005545 dimerization interface [polypeptide binding]; other site 768670005546 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 768670005547 putative binding surface; other site 768670005548 active site 768670005549 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 768670005550 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 768670005551 putative dimer interface [polypeptide binding]; other site 768670005552 [2Fe-2S] cluster binding site [ion binding]; other site 768670005553 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 768670005554 dimer interface [polypeptide binding]; other site 768670005555 [2Fe-2S] cluster binding site [ion binding]; other site 768670005556 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 768670005557 SLBB domain; Region: SLBB; pfam10531 768670005558 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 768670005559 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 768670005560 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 768670005561 catalytic loop [active] 768670005562 iron binding site [ion binding]; other site 768670005563 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 768670005564 4Fe-4S binding domain; Region: Fer4; pfam00037 768670005565 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 768670005566 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 768670005567 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 768670005568 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518 768670005569 nickel binding site [ion binding]; other site 768670005570 Recombination protein O N terminal; Region: RecO_N; pfam11967 768670005571 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 768670005572 Mg2+ transporter Helicobacter pylori CorA-like subgroup; Region: HpCorA-like; cd12836 768670005573 Cl binding site [ion binding]; other site 768670005574 oligomer interface [polypeptide binding]; other site 768670005575 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 768670005576 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768670005577 active site 768670005578 phosphorylation site [posttranslational modification] 768670005579 intermolecular recognition site; other site 768670005580 dimerization interface [polypeptide binding]; other site 768670005581 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768670005582 Walker A motif; other site 768670005583 ATP binding site [chemical binding]; other site 768670005584 Walker B motif; other site 768670005585 arginine finger; other site 768670005586 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 768670005587 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 768670005588 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 768670005589 dimerization interface [polypeptide binding]; other site 768670005590 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768670005591 dimer interface [polypeptide binding]; other site 768670005592 phosphorylation site [posttranslational modification] 768670005593 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768670005594 ATP binding site [chemical binding]; other site 768670005595 Mg2+ binding site [ion binding]; other site 768670005596 G-X-G motif; other site 768670005597 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 768670005598 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768670005599 Walker A motif; other site 768670005600 ATP binding site [chemical binding]; other site 768670005601 Walker B motif; other site 768670005602 arginine finger; other site 768670005603 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768670005604 binding surface 768670005605 TPR motif; other site 768670005606 Tetratricopeptide repeat; Region: TPR_12; pfam13424 768670005607 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 768670005608 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 768670005609 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 768670005610 active site 768670005611 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 768670005612 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 768670005613 RNA binding surface [nucleotide binding]; other site 768670005614 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 768670005615 active site 768670005616 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 768670005617 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 768670005618 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 768670005619 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 768670005620 active site 768670005621 HIGH motif; other site 768670005622 dimer interface [polypeptide binding]; other site 768670005623 KMSKS motif; other site 768670005624 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 768670005625 Peptidase family M50; Region: Peptidase_M50; pfam02163 768670005626 active site 768670005627 putative substrate binding region [chemical binding]; other site 768670005628 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 768670005629 PhoU domain; Region: PhoU; pfam01895 768670005630 PhoU domain; Region: PhoU; pfam01895 768670005631 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 768670005632 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768670005633 active site 768670005634 phosphorylation site [posttranslational modification] 768670005635 intermolecular recognition site; other site 768670005636 dimerization interface [polypeptide binding]; other site 768670005637 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 768670005638 DNA binding site [nucleotide binding] 768670005639 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 768670005640 PAS domain; Region: PAS; smart00091 768670005641 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768670005642 dimer interface [polypeptide binding]; other site 768670005643 phosphorylation site [posttranslational modification] 768670005644 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768670005645 ATP binding site [chemical binding]; other site 768670005646 Mg2+ binding site [ion binding]; other site 768670005647 G-X-G motif; other site 768670005648 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 768670005649 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 768670005650 Walker A/P-loop; other site 768670005651 ATP binding site [chemical binding]; other site 768670005652 Q-loop/lid; other site 768670005653 ABC transporter signature motif; other site 768670005654 Walker B; other site 768670005655 D-loop; other site 768670005656 H-loop/switch region; other site 768670005657 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 768670005658 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 768670005659 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768670005660 dimer interface [polypeptide binding]; other site 768670005661 conserved gate region; other site 768670005662 putative PBP binding loops; other site 768670005663 ABC-ATPase subunit interface; other site 768670005664 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 768670005665 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768670005666 ABC-ATPase subunit interface; other site 768670005667 PBP superfamily domain; Region: PBP_like_2; cl17296 768670005668 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 768670005669 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 768670005670 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 768670005671 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 768670005672 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 768670005673 heterotetramer interface [polypeptide binding]; other site 768670005674 active site pocket [active] 768670005675 cleavage site 768670005676 Permease; Region: Permease; pfam02405 768670005677 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768670005678 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 768670005679 mce related protein; Region: MCE; pfam02470 768670005680 Laminin Domain II; Region: Laminin_II; pfam06009 768670005681 murein transglycosylase C; Provisional; Region: mltC; PRK11671 768670005682 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 768670005683 Nitrogen regulatory protein P-II; Region: P-II; smart00938 768670005684 glutamine synthetase, type I; Region: GlnA; TIGR00653 768670005685 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 768670005686 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 768670005687 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13446 768670005688 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 768670005689 gamma subunit interface [polypeptide binding]; other site 768670005690 epsilon subunit interface [polypeptide binding]; other site 768670005691 LBP interface [polypeptide binding]; other site 768670005692 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 768670005693 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 768670005694 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 768670005695 alpha subunit interaction interface [polypeptide binding]; other site 768670005696 Walker A motif; other site 768670005697 ATP binding site [chemical binding]; other site 768670005698 Walker B motif; other site 768670005699 inhibitor binding site; inhibition site 768670005700 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 768670005701 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 768670005702 core domain interface [polypeptide binding]; other site 768670005703 delta subunit interface [polypeptide binding]; other site 768670005704 epsilon subunit interface [polypeptide binding]; other site 768670005705 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 768670005706 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 768670005707 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 768670005708 beta subunit interaction interface [polypeptide binding]; other site 768670005709 Walker A motif; other site 768670005710 ATP binding site [chemical binding]; other site 768670005711 Walker B motif; other site 768670005712 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 768670005713 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 768670005714 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 768670005715 F0F1 ATP synthase subunit B; Validated; Region: PRK07352 768670005716 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 768670005717 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 768670005718 Phosphoglycerate kinase; Region: PGK; pfam00162 768670005719 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 768670005720 substrate binding site [chemical binding]; other site 768670005721 hinge regions; other site 768670005722 ADP binding site [chemical binding]; other site 768670005723 catalytic site [active] 768670005724 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 768670005725 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 768670005726 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 768670005727 PAS domain; Region: PAS_9; pfam13426 768670005728 comF family protein; Region: comF; TIGR00201 768670005729 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768670005730 active site 768670005731 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 768670005732 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768670005733 binding surface 768670005734 TPR motif; other site 768670005735 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 768670005736 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 768670005737 Tetratricopeptide repeat; Region: TPR_16; pfam13432 768670005738 CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cl17437 768670005739 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 768670005740 CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cl17438 768670005741 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 768670005742 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cl00622 768670005743 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 768670005744 CRISPR-associated protein Cas10/Csm1, subtype III-A/MTUBE; Region: cas_TM1811_Csm1; TIGR02578 768670005745 Domain of unknown function (DUF1887); Region: DUF1887; pfam09002 768670005746 Uncharacterized conserved protein (DUF2276); Region: DUF2276; pfam10040 768670005747 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 768670005748 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768670005749 FeS/SAM binding site; other site 768670005750 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 768670005751 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 768670005752 active site 768670005753 dimer interface [polypeptide binding]; other site 768670005754 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 768670005755 CAAX protease self-immunity; Region: Abi; pfam02517 768670005756 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 768670005757 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768670005758 FeS/SAM binding site; other site 768670005759 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 768670005760 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 768670005761 active site 768670005762 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 768670005763 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 768670005764 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 768670005765 putative active site [active] 768670005766 PhoH-like protein; Region: PhoH; pfam02562 768670005767 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 768670005768 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 768670005769 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 768670005770 metal binding site [ion binding]; metal-binding site 768670005771 nucleotidyl binding site; other site 768670005772 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 768670005773 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 768670005774 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768670005775 metal binding site [ion binding]; metal-binding site 768670005776 active site 768670005777 I-site; other site 768670005778 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 768670005779 putative CheA interaction surface; other site 768670005780 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 768670005781 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 768670005782 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 768670005783 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 768670005784 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 768670005785 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 768670005786 Found in ATP-dependent protease La (LON); Region: LON; smart00464 768670005787 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768670005788 Walker A motif; other site 768670005789 ATP binding site [chemical binding]; other site 768670005790 Walker B motif; other site 768670005791 arginine finger; other site 768670005792 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 768670005793 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 768670005794 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 768670005795 putative dimer interface [polypeptide binding]; other site 768670005796 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 768670005797 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 768670005798 active site 768670005799 tetramer interface; other site 768670005800 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 768670005801 putative ligand binding pocket/active site [active] 768670005802 putative metal binding site [ion binding]; other site 768670005803 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 768670005804 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768670005805 FeS/SAM binding site; other site 768670005806 Response regulator receiver domain; Region: Response_reg; pfam00072 768670005807 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768670005808 active site 768670005809 phosphorylation site [posttranslational modification] 768670005810 intermolecular recognition site; other site 768670005811 dimerization interface [polypeptide binding]; other site 768670005812 GAF domain; Region: GAF_2; pfam13185 768670005813 GAF domain; Region: GAF_3; pfam13492 768670005814 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 768670005815 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 768670005816 Zn2+ binding site [ion binding]; other site 768670005817 Mg2+ binding site [ion binding]; other site 768670005818 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 768670005819 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 768670005820 Uncharacterized conserved protein [Function unknown]; Region: COG1543 768670005821 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 768670005822 active site 768670005823 substrate binding site [chemical binding]; other site 768670005824 catalytic site [active] 768670005825 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 768670005826 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 768670005827 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 768670005828 ADP-glucose phosphorylase; Region: PLN02643 768670005829 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 768670005830 nucleotide binding site/active site [active] 768670005831 HIT family signature motif; other site 768670005832 catalytic residue [active] 768670005833 N-terminal catalytic domain of 4-alpha-glucanotransferase; glycoside hydrolase family 57 (GH57); Region: GH57N_TLGT_like; cd10793 768670005834 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 768670005835 active site 768670005836 catalytic site [active] 768670005837 homodimer interface [polypeptide binding]; other site 768670005838 Lid 1; other site 768670005839 Domain of unknown function (DUF1925); Region: DUF1925; pfam09094 768670005840 Domain of unknown function (DUF1926); Region: DUF1926; pfam09095 768670005841 PAS fold; Region: PAS; pfam00989 768670005842 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768670005843 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768670005844 dimer interface [polypeptide binding]; other site 768670005845 phosphorylation site [posttranslational modification] 768670005846 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768670005847 ATP binding site [chemical binding]; other site 768670005848 Mg2+ binding site [ion binding]; other site 768670005849 G-X-G motif; other site 768670005850 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 768670005851 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 768670005852 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 768670005853 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 768670005854 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 768670005855 Walker A motif; other site 768670005856 ATP binding site [chemical binding]; other site 768670005857 Walker B motif; other site 768670005858 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 768670005859 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 768670005860 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 768670005861 Walker A motif; other site 768670005862 ATP binding site [chemical binding]; other site 768670005863 Walker B motif; other site 768670005864 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 768670005865 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 768670005866 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 768670005867 shikimate binding site; other site 768670005868 NAD(P) binding site [chemical binding]; other site 768670005869 Uncharacterized conserved protein [Function unknown]; Region: COG2928 768670005870 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 768670005871 active site 768670005872 Permease family; Region: Xan_ur_permease; pfam00860 768670005873 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 768670005874 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 768670005875 generic binding surface I; other site 768670005876 generic binding surface II; other site 768670005877 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 768670005878 Zn2+ binding site [ion binding]; other site 768670005879 Mg2+ binding site [ion binding]; other site 768670005880 transcription antitermination factor NusB; Region: nusB; TIGR01951 768670005881 putative RNA binding site [nucleotide binding]; other site 768670005882 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 768670005883 homopentamer interface [polypeptide binding]; other site 768670005884 active site 768670005885 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 768670005886 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 768670005887 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 768670005888 dimerization interface [polypeptide binding]; other site 768670005889 active site 768670005890 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 768670005891 Lumazine binding domain; Region: Lum_binding; pfam00677 768670005892 Lumazine binding domain; Region: Lum_binding; pfam00677 768670005893 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 768670005894 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 768670005895 catalytic motif [active] 768670005896 Zn binding site [ion binding]; other site 768670005897 RibD C-terminal domain; Region: RibD_C; cl17279 768670005898 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 768670005899 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 768670005900 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 768670005901 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768670005902 active site 768670005903 phosphorylation site [posttranslational modification] 768670005904 intermolecular recognition site; other site 768670005905 dimerization interface [polypeptide binding]; other site 768670005906 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768670005907 Walker A motif; other site 768670005908 ATP binding site [chemical binding]; other site 768670005909 Walker B motif; other site 768670005910 arginine finger; other site 768670005911 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 768670005912 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 768670005913 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 768670005914 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 768670005915 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 768670005916 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 768670005917 generic binding surface II; other site 768670005918 generic binding surface I; other site 768670005919 Septum formation initiator; Region: DivIC; cl17659 768670005920 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 768670005921 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768670005922 metal binding site [ion binding]; metal-binding site 768670005923 active site 768670005924 I-site; other site 768670005925 Domain of unknown function (DUF4416); Region: DUF4416; pfam14385 768670005926 bacterial Hfq-like; Region: Hfq; cd01716 768670005927 hexamer interface [polypeptide binding]; other site 768670005928 Sm1 motif; other site 768670005929 RNA binding site [nucleotide binding]; other site 768670005930 Sm2 motif; other site 768670005931 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 768670005932 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 768670005933 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 768670005934 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 768670005935 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768670005936 active site 768670005937 phosphorylation site [posttranslational modification] 768670005938 intermolecular recognition site; other site 768670005939 dimerization interface [polypeptide binding]; other site 768670005940 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 768670005941 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 768670005942 pantothenate kinase; Reviewed; Region: PRK13318 768670005943 TPR repeat; Region: TPR_11; pfam13414 768670005944 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768670005945 TPR motif; other site 768670005946 binding surface 768670005947 TPR repeat; Region: TPR_11; pfam13414 768670005948 TPR repeat; Region: TPR_11; pfam13414 768670005949 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768670005950 binding surface 768670005951 TPR motif; other site 768670005952 Tetratricopeptide repeat; Region: TPR_16; pfam13432 768670005953 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 768670005954 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 768670005955 non-specific DNA binding site [nucleotide binding]; other site 768670005956 salt bridge; other site 768670005957 sequence-specific DNA binding site [nucleotide binding]; other site 768670005958 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 768670005959 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 768670005960 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 768670005961 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768670005962 catalytic residue [active] 768670005963 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 768670005964 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 768670005965 trimerization site [polypeptide binding]; other site 768670005966 active site 768670005967 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 768670005968 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 768670005969 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 768670005970 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 768670005971 CcmB protein; Region: CcmB; cl17444 768670005972 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 768670005973 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 768670005974 Walker A/P-loop; other site 768670005975 ATP binding site [chemical binding]; other site 768670005976 Q-loop/lid; other site 768670005977 ABC transporter signature motif; other site 768670005978 Walker B; other site 768670005979 D-loop; other site 768670005980 H-loop/switch region; other site 768670005981 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 768670005982 CcmE; Region: CcmE; cl00994 768670005983 Protein of unknown function (DUF721); Region: DUF721; pfam05258 768670005984 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 768670005985 Isochorismatase family; Region: Isochorismatase; pfam00857 768670005986 catalytic triad [active] 768670005987 metal binding site [ion binding]; metal-binding site 768670005988 conserved cis-peptide bond; other site 768670005989 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 768670005990 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 768670005991 active site 768670005992 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 768670005993 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 768670005994 Transcriptional regulator [Transcription]; Region: LysR; COG0583 768670005995 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 768670005996 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 768670005997 putative dimerization interface [polypeptide binding]; other site 768670005998 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 768670005999 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 768670006000 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 768670006001 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 768670006002 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 768670006003 HlyD family secretion protein; Region: HlyD_3; pfam13437 768670006004 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 768670006005 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768670006006 dimerization interface [polypeptide binding]; other site 768670006007 putative DNA binding site [nucleotide binding]; other site 768670006008 putative Zn2+ binding site [ion binding]; other site 768670006009 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 768670006010 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768670006011 active site 768670006012 phosphorylation site [posttranslational modification] 768670006013 intermolecular recognition site; other site 768670006014 dimerization interface [polypeptide binding]; other site 768670006015 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768670006016 Walker A motif; other site 768670006017 ATP binding site [chemical binding]; other site 768670006018 Walker B motif; other site 768670006019 arginine finger; other site 768670006020 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 768670006021 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 768670006022 DctM-like transporters; Region: DctM; pfam06808 768670006023 TRAP transporter, DctM subunit; Region: dctM; TIGR00786 768670006024 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 768670006025 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 768670006026 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 768670006027 PAS domain; Region: PAS_9; pfam13426 768670006028 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 768670006029 GAF domain; Region: GAF; pfam01590 768670006030 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 768670006031 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768670006032 metal binding site [ion binding]; metal-binding site 768670006033 active site 768670006034 I-site; other site 768670006035 glycogen synthase; Provisional; Region: glgA; PRK00654 768670006036 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 768670006037 ADP-binding pocket [chemical binding]; other site 768670006038 homodimer interface [polypeptide binding]; other site 768670006039 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 768670006040 Transcriptional regulator [Transcription]; Region: IclR; COG1414 768670006041 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 768670006042 putative DNA binding site [nucleotide binding]; other site 768670006043 putative Zn2+ binding site [ion binding]; other site 768670006044 Bacterial transcriptional regulator; Region: IclR; pfam01614 768670006045 Transcriptional regulators [Transcription]; Region: FadR; COG2186 768670006046 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768670006047 DNA-binding site [nucleotide binding]; DNA binding site 768670006048 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 768670006049 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 768670006050 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 768670006051 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 768670006052 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 768670006053 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 768670006054 Cysteine-rich domain; Region: CCG; pfam02754 768670006055 Cysteine-rich domain; Region: CCG; pfam02754 768670006056 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 768670006057 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 768670006058 Transglycosylase; Region: Transgly; cl17702 768670006059 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882 768670006060 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 768670006061 cell division protein FtsZ; Validated; Region: PRK09330 768670006062 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 768670006063 nucleotide binding site [chemical binding]; other site 768670006064 SulA interaction site; other site 768670006065 cell division protein FtsA; Region: ftsA; TIGR01174 768670006066 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 768670006067 nucleotide binding site [chemical binding]; other site 768670006068 Cell division protein FtsA; Region: FtsA; pfam14450 768670006069 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 768670006070 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 768670006071 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 768670006072 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 768670006073 ATP-grasp domain; Region: ATP-grasp_4; cl17255 768670006074 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 768670006075 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 768670006076 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 768670006077 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 768670006078 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 768670006079 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 768670006080 active site 768670006081 homodimer interface [polypeptide binding]; other site 768670006082 cell division protein FtsW; Region: ftsW; TIGR02614 768670006083 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 768670006084 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 768670006085 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 768670006086 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 768670006087 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 768670006088 Mg++ binding site [ion binding]; other site 768670006089 putative catalytic motif [active] 768670006090 putative substrate binding site [chemical binding]; other site 768670006091 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 768670006092 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 768670006093 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 768670006094 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 768670006095 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 768670006096 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 768670006097 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 768670006098 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 768670006099 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 768670006100 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 768670006101 MraW methylase family; Region: Methyltransf_5; cl17771 768670006102 cell division protein MraZ; Reviewed; Region: PRK00326 768670006103 MraZ protein; Region: MraZ; pfam02381 768670006104 MraZ protein; Region: MraZ; pfam02381 768670006105 PAS fold; Region: PAS_3; pfam08447 768670006106 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768670006107 putative active site [active] 768670006108 heme pocket [chemical binding]; other site 768670006109 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768670006110 dimer interface [polypeptide binding]; other site 768670006111 phosphorylation site [posttranslational modification] 768670006112 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768670006113 ATP binding site [chemical binding]; other site 768670006114 Mg2+ binding site [ion binding]; other site 768670006115 G-X-G motif; other site 768670006116 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768670006117 active site 768670006118 phosphorylation site [posttranslational modification] 768670006119 intermolecular recognition site; other site 768670006120 dimerization interface [polypeptide binding]; other site 768670006121 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 768670006122 Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972 768670006123 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 768670006124 active site 768670006125 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 768670006126 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes SLAC1 (Slow Anion Channel-Associated 1); Region: TDT_SLAC1_like; cd09323 768670006127 gating phenylalanine in ion channel; other site 768670006128 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 768670006129 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 768670006130 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768670006131 ATP binding site [chemical binding]; other site 768670006132 putative Mg++ binding site [ion binding]; other site 768670006133 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 768670006134 nucleotide binding region [chemical binding]; other site 768670006135 ATP-binding site [chemical binding]; other site 768670006136 TRCF domain; Region: TRCF; pfam03461 768670006137 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 768670006138 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 768670006139 active site 768670006140 nucleotide binding site [chemical binding]; other site 768670006141 HIGH motif; other site 768670006142 KMSKS motif; other site 768670006143 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 768670006144 dimer interface [polypeptide binding]; other site 768670006145 active site 768670006146 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 768670006147 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 768670006148 putative active site [active] 768670006149 PhoH-like protein; Region: PhoH; pfam02562 768670006150 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 768670006151 putative hydrophobic ligand binding site [chemical binding]; other site 768670006152 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 768670006153 TIGR01777 family protein; Region: yfcH 768670006154 NAD(P) binding site [chemical binding]; other site 768670006155 active site 768670006156 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 768670006157 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 768670006158 putative recombination protein RecB; Provisional; Region: PRK13909 768670006159 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 768670006160 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 768670006161 NAD(P) binding site [chemical binding]; other site 768670006162 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 768670006163 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768670006164 dimer interface [polypeptide binding]; other site 768670006165 conserved gate region; other site 768670006166 putative PBP binding loops; other site 768670006167 ABC-ATPase subunit interface; other site 768670006168 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768670006169 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 768670006170 substrate binding pocket [chemical binding]; other site 768670006171 membrane-bound complex binding site; other site 768670006172 hinge residues; other site 768670006173 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768670006174 dimer interface [polypeptide binding]; other site 768670006175 conserved gate region; other site 768670006176 ABC-ATPase subunit interface; other site 768670006177 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 768670006178 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 768670006179 active site 768670006180 NTP binding site [chemical binding]; other site 768670006181 metal binding triad [ion binding]; metal-binding site 768670006182 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 768670006183 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 768670006184 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 768670006185 Uncharacterized conserved protein [Function unknown]; Region: COG1751 768670006186 Pyruvate kinase, alpha/beta domain; Region: PK_C; pfam02887 768670006187 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 768670006188 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 768670006189 active site 768670006190 metal binding site [ion binding]; metal-binding site 768670006191 homotetramer interface [polypeptide binding]; other site 768670006192 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 768670006193 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 768670006194 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 768670006195 substrate binding site [chemical binding]; other site 768670006196 active site 768670006197 ferrochelatase; Reviewed; Region: hemH; PRK00035 768670006198 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 768670006199 active site 768670006200 C-terminal domain interface [polypeptide binding]; other site 768670006201 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 768670006202 active site 768670006203 N-terminal domain interface [polypeptide binding]; other site 768670006204 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 768670006205 UbiA prenyltransferase family; Region: UbiA; pfam01040 768670006206 aromatic acid decarboxylase; Validated; Region: PRK05920 768670006207 Flavoprotein; Region: Flavoprotein; pfam02441 768670006208 HDOD domain; Region: HDOD; pfam08668 768670006209 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 768670006210 Zn2+ binding site [ion binding]; other site 768670006211 Mg2+ binding site [ion binding]; other site 768670006212 Protein kinase domain; Region: Pkinase; pfam00069 768670006213 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 768670006214 active site 768670006215 ATP binding site [chemical binding]; other site 768670006216 substrate binding site [chemical binding]; other site 768670006217 activation loop (A-loop); other site 768670006218 Protein of unknown function (DUF342); Region: DUF342; pfam03961 768670006219 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 768670006220 ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163 768670006221 4Fe-4S binding domain; Region: Fer4_5; pfam12801 768670006222 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 768670006223 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 768670006224 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 768670006225 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 768670006226 Uncharacterized conserved protein [Function unknown]; Region: COG2006 768670006227 Domain of unknown function (DUF362); Region: DUF362; pfam04015 768670006228 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 768670006229 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 768670006230 motif II; other site 768670006231 Response regulator receiver domain; Region: Response_reg; pfam00072 768670006232 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768670006233 active site 768670006234 phosphorylation site [posttranslational modification] 768670006235 intermolecular recognition site; other site 768670006236 dimerization interface [polypeptide binding]; other site 768670006237 HDOD domain; Region: HDOD; pfam08668 768670006238 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 768670006239 Zn2+ binding site [ion binding]; other site 768670006240 Mg2+ binding site [ion binding]; other site 768670006241 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 768670006242 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 768670006243 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768670006244 S-adenosylmethionine binding site [chemical binding]; other site 768670006245 menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701 768670006246 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 768670006247 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 768670006248 minor groove reading motif; other site 768670006249 helix-hairpin-helix signature motif; other site 768670006250 substrate binding pocket [chemical binding]; other site 768670006251 active site 768670006252 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 768670006253 Transposase, Mutator family; Region: Transposase_mut; pfam00872 768670006254 MULE transposase domain; Region: MULE; pfam10551 768670006255 Cache domain; Region: Cache_1; pfam02743 768670006256 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 768670006257 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768670006258 metal binding site [ion binding]; metal-binding site 768670006259 active site 768670006260 I-site; other site 768670006261 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 768670006262 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 768670006263 Sulfate transporter family; Region: Sulfate_transp; pfam00916 768670006264 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 768670006265 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 768670006266 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 768670006267 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 768670006268 nucleotide binding pocket [chemical binding]; other site 768670006269 K-X-D-G motif; other site 768670006270 catalytic site [active] 768670006271 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 768670006272 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 768670006273 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 768670006274 Dimer interface [polypeptide binding]; other site 768670006275 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 768670006276 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 768670006277 Peptidase family U32; Region: Peptidase_U32; pfam01136 768670006278 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 768670006279 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768670006280 S-adenosylmethionine binding site [chemical binding]; other site 768670006281 Uncharacterized conserved protein [Function unknown]; Region: COG3334 768670006282 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 768670006283 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 768670006284 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 768670006285 Walker A motif/ATP binding site; other site 768670006286 Walker B motif; other site 768670006287 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 768670006288 Flagellar assembly protein FliH; Region: FliH; pfam02108 768670006289 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 768670006290 FliG C-terminal domain; Region: FliG_C; pfam01706 768670006291 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 768670006292 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 768670006293 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 768670006294 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 768670006295 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 768670006296 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 768670006297 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 768670006298 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 768670006299 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 768670006300 AIR carboxylase; Region: AIRC; pfam00731 768670006301 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 768670006302 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 768670006303 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 768670006304 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 768670006305 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 768670006306 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768670006307 FeS/SAM binding site; other site 768670006308 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 768670006309 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 768670006310 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 768670006311 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 768670006312 inhibitor-cofactor binding pocket; inhibition site 768670006313 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768670006314 catalytic residue [active] 768670006315 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 768670006316 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 768670006317 catalytic residue [active] 768670006318 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 768670006319 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 768670006320 Ligand binding site; other site 768670006321 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 768670006322 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 768670006323 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 768670006324 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 768670006325 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 768670006326 active site 768670006327 substrate binding site [chemical binding]; other site 768670006328 trimer interface [polypeptide binding]; other site 768670006329 CoA binding site [chemical binding]; other site 768670006330 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 768670006331 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 768670006332 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 768670006333 active site 768670006334 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 768670006335 homodimer interface [polypeptide binding]; other site 768670006336 putative trimer interface [polypeptide binding]; other site 768670006337 Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132 768670006338 putative CoA binding site [chemical binding]; other site 768670006339 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 768670006340 putative trimer interface [polypeptide binding]; other site 768670006341 putative active site [active] 768670006342 putative substrate binding site [chemical binding]; other site 768670006343 putative CoA binding site [chemical binding]; other site 768670006344 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 768670006345 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 768670006346 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 768670006347 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 768670006348 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768670006349 binding surface 768670006350 TPR motif; other site 768670006351 DNA uptake lipoprotein [General function prediction only]; Region: ComL; COG4105 768670006352 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 768670006353 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 768670006354 TPR motif; other site 768670006355 binding surface 768670006356 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768670006357 dimer interface [polypeptide binding]; other site 768670006358 phosphorylation site [posttranslational modification] 768670006359 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768670006360 ATP binding site [chemical binding]; other site 768670006361 Mg2+ binding site [ion binding]; other site 768670006362 G-X-G motif; other site 768670006363 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 768670006364 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768670006365 active site 768670006366 phosphorylation site [posttranslational modification] 768670006367 intermolecular recognition site; other site 768670006368 dimerization interface [polypeptide binding]; other site 768670006369 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 768670006370 Walker A motif; other site 768670006371 ATP binding site [chemical binding]; other site 768670006372 Walker B motif; other site 768670006373 arginine finger; other site 768670006374 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 768670006375 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 768670006376 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 768670006377 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 768670006378 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 768670006379 dihydrodipicolinate synthase; Region: dapA; TIGR00674 768670006380 dimer interface [polypeptide binding]; other site 768670006381 active site 768670006382 catalytic residue [active] 768670006383 dihydrodipicolinate reductase; Provisional; Region: PRK00048 768670006384 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 768670006385 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 768670006386 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 768670006387 dimer interface [polypeptide binding]; other site 768670006388 catalytic triad [active] 768670006389 peroxidatic and resolving cysteines [active] 768670006390 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 768670006391 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 768670006392 catalytic loop [active] 768670006393 iron binding site [ion binding]; other site 768670006394 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 768670006395 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 768670006396 Walker A/P-loop; other site 768670006397 ATP binding site [chemical binding]; other site 768670006398 Q-loop/lid; other site 768670006399 ABC transporter signature motif; other site 768670006400 Walker B; other site 768670006401 D-loop; other site 768670006402 H-loop/switch region; other site 768670006403 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 768670006404 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 768670006405 dimer interface [polypeptide binding]; other site 768670006406 conserved gate region; other site 768670006407 putative PBP binding loops; other site 768670006408 ABC-ATPase subunit interface; other site 768670006409 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768670006410 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 768670006411 substrate binding pocket [chemical binding]; other site 768670006412 membrane-bound complex binding site; other site 768670006413 hinge residues; other site 768670006414 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 768670006415 FOG: CBS domain [General function prediction only]; Region: COG0517 768670006416 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 768670006417 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 768670006418 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 768670006419 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 768670006420 acyl-activating enzyme (AAE) consensus motif; other site 768670006421 active site 768670006422 AMP binding site [chemical binding]; other site 768670006423 CoA binding site [chemical binding]; other site 768670006424 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 768670006425 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 768670006426 Walker A/P-loop; other site 768670006427 ATP binding site [chemical binding]; other site 768670006428 Q-loop/lid; other site 768670006429 ABC transporter signature motif; other site 768670006430 Walker B; other site 768670006431 D-loop; other site 768670006432 H-loop/switch region; other site 768670006433 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 768670006434 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 768670006435 putative ligand binding site [chemical binding]; other site 768670006436 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 768670006437 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 768670006438 TM-ABC transporter signature motif; other site 768670006439 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 768670006440 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 768670006441 TM-ABC transporter signature motif; other site 768670006442 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 768670006443 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 768670006444 acyl-activating enzyme (AAE) consensus motif; other site 768670006445 putative AMP binding site [chemical binding]; other site 768670006446 putative active site [active] 768670006447 putative CoA binding site [chemical binding]; other site 768670006448 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 768670006449 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 768670006450 Walker A/P-loop; other site 768670006451 ATP binding site [chemical binding]; other site 768670006452 Q-loop/lid; other site 768670006453 ABC transporter signature motif; other site 768670006454 Walker B; other site 768670006455 D-loop; other site 768670006456 H-loop/switch region; other site 768670006457 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 768670006458 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 768670006459 Zn binding site [ion binding]; other site 768670006460 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 768670006461 exopolyphosphatase; Region: exo_poly_only; TIGR03706 768670006462 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 768670006463 Transcriptional regulators [Transcription]; Region: GntR; COG1802 768670006464 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768670006465 DNA-binding site [nucleotide binding]; DNA binding site 768670006466 FCD domain; Region: FCD; pfam07729 768670006467 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 768670006468 DNA-binding site [nucleotide binding]; DNA binding site 768670006469 Transcriptional regulators [Transcription]; Region: GntR; COG1802 768670006470 FCD domain; Region: FCD; pfam07729 768670006471 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 768670006472 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 768670006473 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 768670006474 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 768670006475 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 768670006476 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 768670006477 active site 768670006478 phosphorylation site [posttranslational modification] 768670006479 CHASE2 domain; Region: CHASE2; pfam05226 768670006480 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 768670006481 cyclase homology domain; Region: CHD; cd07302 768670006482 nucleotidyl binding site; other site 768670006483 metal binding site [ion binding]; metal-binding site 768670006484 dimer interface [polypeptide binding]; other site 768670006485 hypothetical protein; Provisional; Region: PRK04194 768670006486 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 768670006487 FAD binding domain; Region: FAD_binding_4; pfam01565 768670006488 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 768670006489 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 768670006490 Cysteine-rich domain; Region: CCG; pfam02754 768670006491 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 768670006492 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 768670006493 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 768670006494 FeS/SAM binding site; other site 768670006495 TRAM domain; Region: TRAM; pfam01938 768670006496 Bifunctional nuclease; Region: DNase-RNase; pfam02577 768670006497 Predicted amidohydrolase [General function prediction only]; Region: COG0388 768670006498 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 768670006499 active site 768670006500 catalytic triad [active] 768670006501 dimer interface [polypeptide binding]; other site 768670006502 Domain of unknown function (DUF3783); Region: DUF3783; pfam12646 768670006503 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 768670006504 active site residue [active] 768670006505 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 768670006506 active site residue [active] 768670006507 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 768670006508 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 768670006509 domain interfaces; other site 768670006510 active site 768670006511 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 768670006512 Predicted membrane protein [Function unknown]; Region: XynA; COG2314 768670006513 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 768670006514 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 768670006515 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 768670006516 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 768670006517 HsdM N-terminal domain; Region: HsdM_N; pfam12161 768670006518 Methyltransferase domain; Region: Methyltransf_26; pfam13659 768670006519 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 768670006520 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 768670006521 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 768670006522 ATP binding site [chemical binding]; other site 768670006523 putative Mg++ binding site [ion binding]; other site 768670006524 nucleotide binding region [chemical binding]; other site 768670006525 helicase superfamily c-terminal domain; Region: HELICc; smart00490 768670006526 ATP-binding site [chemical binding]; other site 768670006527 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 768670006528 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 768670006529 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 768670006530 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 768670006531 amino acid carrier protein; Region: agcS; TIGR00835 768670006532 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 768670006533 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 768670006534 active site clefts [active] 768670006535 zinc binding site [ion binding]; other site 768670006536 dimer interface [polypeptide binding]; other site 768670006537 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 768670006538 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 768670006539 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 768670006540 active site 768670006541 hypothetical protein; Provisional; Region: PRK06361 768670006542 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 768670006543 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 768670006544 dimer interface [polypeptide binding]; other site 768670006545 PYR/PP interface [polypeptide binding]; other site 768670006546 TPP binding site [chemical binding]; other site 768670006547 substrate binding site [chemical binding]; other site 768670006548 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 768670006549 TPP-binding site; other site 768670006550 4Fe-4S binding domain; Region: Fer4; pfam00037 768670006551 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 768670006552 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 768670006553 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 768670006554 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768670006555 dimer interface [polypeptide binding]; other site 768670006556 phosphorylation site [posttranslational modification] 768670006557 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768670006558 ATP binding site [chemical binding]; other site 768670006559 Mg2+ binding site [ion binding]; other site 768670006560 G-X-G motif; other site 768670006561 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 768670006562 metal binding triad; other site 768670006563 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 768670006564 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 768670006565 metal binding triad; other site 768670006566 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 768670006567 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 768670006568 thiamine phosphate binding site [chemical binding]; other site 768670006569 active site 768670006570 pyrophosphate binding site [ion binding]; other site 768670006571 NADH-quinone oxidoreductase, chain G; Region: NuoG; TIGR01973 768670006572 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 768670006573 catalytic loop [active] 768670006574 iron binding site [ion binding]; other site 768670006575 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 768670006576 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368 768670006577 molybdopterin cofactor binding site; other site 768670006578 NADPH-dependent glutamate synthase beta chain and related oxidoreductases [Amino acid transport and metabolism / General function prediction only]; Region: GltD; COG0493 768670006579 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 768670006580 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 768670006581 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 768670006582 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 768670006583 [4Fe-4S] binding site [ion binding]; other site 768670006584 molybdopterin cofactor binding site; other site 768670006585 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 768670006586 molybdopterin cofactor binding site; other site 768670006587 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 768670006588 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 768670006589 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 768670006590 4Fe-4S binding domain; Region: Fer4; pfam00037 768670006591 ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163 768670006592 Histidine kinase; Region: HisKA_3; pfam07730 768670006593 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768670006594 ATP binding site [chemical binding]; other site 768670006595 Mg2+ binding site [ion binding]; other site 768670006596 G-X-G motif; other site 768670006597 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 768670006598 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768670006599 active site 768670006600 phosphorylation site [posttranslational modification] 768670006601 intermolecular recognition site; other site 768670006602 dimerization interface [polypeptide binding]; other site 768670006603 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 768670006604 DNA binding residues [nucleotide binding] 768670006605 dimerization interface [polypeptide binding]; other site 768670006606 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 768670006607 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 768670006608 N-terminal plug; other site 768670006609 ligand-binding site [chemical binding]; other site 768670006610 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 768670006611 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 768670006612 intersubunit interface [polypeptide binding]; other site 768670006613 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 768670006614 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 768670006615 ABC-ATPase subunit interface; other site 768670006616 dimer interface [polypeptide binding]; other site 768670006617 putative PBP binding regions; other site 768670006618 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 768670006619 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 768670006620 Walker A/P-loop; other site 768670006621 ATP binding site [chemical binding]; other site 768670006622 Q-loop/lid; other site 768670006623 ABC transporter signature motif; other site 768670006624 Walker B; other site 768670006625 D-loop; other site 768670006626 H-loop/switch region; other site 768670006627 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 768670006628 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 768670006629 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 768670006630 homotrimer interface [polypeptide binding]; other site 768670006631 Walker A motif; other site 768670006632 GTP binding site [chemical binding]; other site 768670006633 Walker B motif; other site 768670006634 Cysteine-rich small domain; Region: zf-like; cl00946 768670006635 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 768670006636 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 768670006637 putative dimer interface [polypeptide binding]; other site 768670006638 active site pocket [active] 768670006639 putative cataytic base [active] 768670006640 cobalamin synthase; Reviewed; Region: cobS; PRK00235 768670006641 Gram-negative bacterial tonB protein; Region: TonB; cl10048 768670006642 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 768670006643 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 768670006644 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 768670006645 Ligand Binding Site [chemical binding]; other site 768670006646 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 768670006647 Ligand Binding Site [chemical binding]; other site 768670006648 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 768670006649 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768670006650 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 768670006651 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 768670006652 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 768670006653 Walker A/P-loop; other site 768670006654 ATP binding site [chemical binding]; other site 768670006655 Q-loop/lid; other site 768670006656 ABC transporter signature motif; other site 768670006657 Walker B; other site 768670006658 D-loop; other site 768670006659 H-loop/switch region; other site 768670006660 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 768670006661 HlyD family secretion protein; Region: HlyD_3; pfam13437 768670006662 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 768670006663 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 768670006664 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 768670006665 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 768670006666 Outer membrane efflux protein; Region: OEP; pfam02321 768670006667 Outer membrane efflux protein; Region: OEP; pfam02321 768670006668 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 768670006669 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 768670006670 HlyD family secretion protein; Region: HlyD_3; pfam13437 768670006671 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 768670006672 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768670006673 putative substrate translocation pore; other site 768670006674 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768670006675 dimer interface [polypeptide binding]; other site 768670006676 phosphorylation site [posttranslational modification] 768670006677 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768670006678 ATP binding site [chemical binding]; other site 768670006679 Mg2+ binding site [ion binding]; other site 768670006680 G-X-G motif; other site 768670006681 peroxiredoxin; Provisional; Region: PRK13189 768670006682 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 768670006683 dimer interface [polypeptide binding]; other site 768670006684 decamer (pentamer of dimers) interface [polypeptide binding]; other site 768670006685 catalytic triad [active] 768670006686 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 768670006687 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 768670006688 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 768670006689 DNA binding residues [nucleotide binding] 768670006690 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 768670006691 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 768670006692 substrate binding pocket [chemical binding]; other site 768670006693 membrane-bound complex binding site; other site 768670006694 hinge residues; other site 768670006695 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 768670006696 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 768670006697 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 768670006698 putative active site [active] 768670006699 heme pocket [chemical binding]; other site 768670006700 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768670006701 dimer interface [polypeptide binding]; other site 768670006702 phosphorylation site [posttranslational modification] 768670006703 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768670006704 ATP binding site [chemical binding]; other site 768670006705 Mg2+ binding site [ion binding]; other site 768670006706 G-X-G motif; other site 768670006707 Response regulator receiver domain; Region: Response_reg; pfam00072 768670006708 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768670006709 active site 768670006710 phosphorylation site [posttranslational modification] 768670006711 intermolecular recognition site; other site 768670006712 dimerization interface [polypeptide binding]; other site 768670006713 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 768670006714 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 768670006715 inhibitor-cofactor binding pocket; inhibition site 768670006716 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768670006717 catalytic residue [active] 768670006718 Domain of unknown function DUF77; Region: DUF77; pfam01910 768670006719 Predicted transcriptional regulator [Transcription]; Region: COG2378 768670006720 WYL domain; Region: WYL; pfam13280 768670006721 The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p; Region: HIRAN; smart00910 768670006722 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 768670006723 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 768670006724 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 768670006725 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 768670006726 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 768670006727 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 768670006728 Transposase, Mutator family; Region: Transposase_mut; pfam00872 768670006729 MULE transposase domain; Region: MULE; pfam10551 768670006730 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722 768670006731 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 768670006732 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 768670006733 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 768670006734 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 768670006735 substrate-cofactor binding pocket; other site 768670006736 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768670006737 catalytic residue [active] 768670006738 chorismate binding enzyme; Region: Chorismate_bind; cl10555 768670006739 Domain of unknown function (DUF1858); Region: DUF1858; cl14817 768670006740 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 768670006741 dimer interface [polypeptide binding]; other site 768670006742 ADP-ribose binding site [chemical binding]; other site 768670006743 active site 768670006744 nudix motif; other site 768670006745 metal binding site [ion binding]; metal-binding site 768670006746 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 768670006747 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 768670006748 homodimer interface [polypeptide binding]; other site 768670006749 metal binding site [ion binding]; metal-binding site 768670006750 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 768670006751 homodimer interface [polypeptide binding]; other site 768670006752 active site 768670006753 putative chemical substrate binding site [chemical binding]; other site 768670006754 metal binding site [ion binding]; metal-binding site 768670006755 Cache domain; Region: Cache_1; pfam02743 768670006756 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768670006757 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768670006758 ATP binding site [chemical binding]; other site 768670006759 Mg2+ binding site [ion binding]; other site 768670006760 G-X-G motif; other site 768670006761 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 768670006762 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 768670006763 intersubunit interface [polypeptide binding]; other site 768670006764 active site 768670006765 zinc binding site [ion binding]; other site 768670006766 Na+ binding site [ion binding]; other site 768670006767 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 768670006768 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 768670006769 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 768670006770 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 768670006771 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 768670006772 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 768670006773 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 768670006774 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 768670006775 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 768670006776 competence damage-inducible protein A; Provisional; Region: PRK00549 768670006777 putative MPT binding site; other site 768670006778 Competence-damaged protein; Region: CinA; pfam02464 768670006779 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 768670006780 tetramer interfaces [polypeptide binding]; other site 768670006781 binuclear metal-binding site [ion binding]; other site 768670006782 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 768670006783 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 768670006784 catalytic residues [active] 768670006785 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 768670006786 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 768670006787 putative active site [active] 768670006788 oxyanion strand; other site 768670006789 catalytic triad [active] 768670006790 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 768670006791 putative active site pocket [active] 768670006792 4-fold oligomerization interface [polypeptide binding]; other site 768670006793 metal binding residues [ion binding]; metal-binding site 768670006794 3-fold/trimer interface [polypeptide binding]; other site 768670006795 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 768670006796 heme-binding site [chemical binding]; other site 768670006797 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 768670006798 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 768670006799 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 768670006800 active site 768670006801 catalytic residues [active] 768670006802 metal binding site [ion binding]; metal-binding site 768670006803 Superoxide reductase-like (SORL) domain, class II; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_classII; cd03172 768670006804 non-heme iron binding site [ion binding]; other site 768670006805 tetramer interface [polypeptide binding]; other site 768670006806 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768670006807 putative substrate translocation pore; other site 768670006808 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768670006809 Conserved oligomeric complex COG6; Region: COG6; smart01087 768670006810 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 768670006811 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 768670006812 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 768670006813 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 768670006814 NADP-binding site; other site 768670006815 homotetramer interface [polypeptide binding]; other site 768670006816 substrate binding site [chemical binding]; other site 768670006817 homodimer interface [polypeptide binding]; other site 768670006818 active site 768670006819 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 768670006820 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 768670006821 NADP binding site [chemical binding]; other site 768670006822 active site 768670006823 putative substrate binding site [chemical binding]; other site 768670006824 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 768670006825 active site 768670006826 cosubstrate binding site; other site 768670006827 substrate binding site [chemical binding]; other site 768670006828 catalytic site [active] 768670006829 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 768670006830 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 768670006831 inhibitor-cofactor binding pocket; inhibition site 768670006832 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768670006833 catalytic residue [active] 768670006834 Methyltransferase domain; Region: Methyltransf_23; pfam13489 768670006835 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768670006836 S-adenosylmethionine binding site [chemical binding]; other site 768670006837 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 768670006838 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 768670006839 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 768670006840 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 768670006841 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 768670006842 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 768670006843 metal-binding site 768670006844 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 768670006845 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 768670006846 Transposase, Mutator family; Region: Transposase_mut; pfam00872 768670006847 MULE transposase domain; Region: MULE; pfam10551 768670006848 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 768670006849 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 768670006850 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 768670006851 putative ADP-binding pocket [chemical binding]; other site 768670006852 putative acyl transferase; Provisional; Region: PRK10502 768670006853 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 768670006854 putative trimer interface [polypeptide binding]; other site 768670006855 putative active site [active] 768670006856 putative substrate binding site [chemical binding]; other site 768670006857 putative CoA binding site [chemical binding]; other site 768670006858 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 768670006859 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 768670006860 metal-binding site 768670006861 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 768670006862 This subfamily is composed of uncharacterized bacterial glycosyltransferases in the MraY-like family. This family contains both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases, which...; Region: GT_MraY_like; cd06912 768670006863 Mg++ binding site [ion binding]; other site 768670006864 putative catalytic motif [active] 768670006865 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 768670006866 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 768670006867 active site 768670006868 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 768670006869 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 768670006870 domain interfaces; other site 768670006871 active site 768670006872 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 768670006873 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 768670006874 tRNA; other site 768670006875 putative tRNA binding site [nucleotide binding]; other site 768670006876 putative NADP binding site [chemical binding]; other site 768670006877 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 768670006878 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 768670006879 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 768670006880 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 768670006881 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 768670006882 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 768670006883 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 768670006884 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 768670006885 dimer interface [polypeptide binding]; other site 768670006886 PYR/PP interface [polypeptide binding]; other site 768670006887 TPP binding site [chemical binding]; other site 768670006888 substrate binding site [chemical binding]; other site 768670006889 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 768670006890 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 768670006891 TPP-binding site [chemical binding]; other site 768670006892 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 768670006893 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Region: PpsA; COG0574 768670006894 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 768670006895 phosphoglucomutase; Validated; Region: PRK07564 768670006896 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 768670006897 active site 768670006898 substrate binding site [chemical binding]; other site 768670006899 metal binding site [ion binding]; metal-binding site 768670006900 Methyltransferase domain; Region: Methyltransf_23; pfam13489 768670006901 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 768670006902 S-adenosylmethionine binding site [chemical binding]; other site 768670006903 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 768670006904 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 768670006905 active site 768670006906 FMN binding site [chemical binding]; other site 768670006907 substrate binding site [chemical binding]; other site 768670006908 putative catalytic residue [active] 768670006909 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 768670006910 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 768670006911 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 768670006912 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 768670006913 hypothetical protein; Reviewed; Region: PRK12497 768670006914 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 768670006915 RNA/DNA hybrid binding site [nucleotide binding]; other site 768670006916 active site 768670006917 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 768670006918 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 768670006919 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 768670006920 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 768670006921 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 768670006922 active site 768670006923 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 768670006924 protein binding site [polypeptide binding]; other site 768670006925 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 768670006926 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 768670006927 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 768670006928 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 768670006929 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 768670006930 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 768670006931 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 768670006932 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 768670006933 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 768670006934 catalytic residue [active] 768670006935 putative FPP diphosphate binding site; other site 768670006936 putative FPP binding hydrophobic cleft; other site 768670006937 dimer interface [polypeptide binding]; other site 768670006938 putative IPP diphosphate binding site; other site 768670006939 ribosome recycling factor; Reviewed; Region: frr; PRK00083 768670006940 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 768670006941 hinge region; other site 768670006942 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 768670006943 putative nucleotide binding site [chemical binding]; other site 768670006944 uridine monophosphate binding site [chemical binding]; other site 768670006945 homohexameric interface [polypeptide binding]; other site 768670006946 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 768670006947 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 768670006948 Catalytic site [active] 768670006949 GTP-binding protein LepA; Provisional; Region: PRK05433 768670006950 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 768670006951 G1 box; other site 768670006952 putative GEF interaction site [polypeptide binding]; other site 768670006953 GTP/Mg2+ binding site [chemical binding]; other site 768670006954 Switch I region; other site 768670006955 G2 box; other site 768670006956 G3 box; other site 768670006957 Switch II region; other site 768670006958 G4 box; other site 768670006959 G5 box; other site 768670006960 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 768670006961 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 768670006962 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 768670006963 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 768670006964 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 768670006965 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 768670006966 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 768670006967 signal recognition particle protein; Provisional; Region: PRK10867 768670006968 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 768670006969 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 768670006970 P loop; other site 768670006971 GTP binding site [chemical binding]; other site 768670006972 Signal peptide binding domain; Region: SRP_SPB; pfam02978 768670006973 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 768670006974 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 768670006975 hypothetical protein; Provisional; Region: PRK00468 768670006976 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 768670006977 RimM N-terminal domain; Region: RimM; pfam01782 768670006978 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 768670006979 SAM-dependent RNA methyltransferase; Region: Methyltrn_RNA_4; pfam09936 768670006980 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 768670006981 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 768670006982 23S rRNA interface [nucleotide binding]; other site 768670006983 L3 interface [polypeptide binding]; other site 768670006984 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 768670006985 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 768670006986 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 768670006987 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 768670006988 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 768670006989 RNA binding site [nucleotide binding]; other site 768670006990 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 768670006991 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 768670006992 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768670006993 catalytic residue [active] 768670006994 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases and ATP sulphurylases. The domain forms a apha/beta/apha fold which binds to Adenosine group; Region: Alpha_ANH_like; cd01986 768670006995 Ligand Binding Site [chemical binding]; other site 768670006996 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 768670006997 Major Facilitator Superfamily; Region: MFS_1; pfam07690 768670006998 putative substrate translocation pore; other site 768670006999 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 768670007000 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 768670007001 Putative ATP-dependent Lon protease; Region: Lon_2; pfam13337 768670007002 TIGR02687 family protein; Region: TIGR02687 768670007003 PglZ domain; Region: PglZ; pfam08665 768670007004 Methyltransferase domain; Region: Methyltransf_26; pfam13659 768670007005 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 768670007006 Domain of unknown function (DUF1788); Region: DUF1788; pfam08747 768670007007 Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849 768670007008 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 768670007009 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 768670007010 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 768670007011 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 768670007012 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 768670007013 ring oligomerisation interface [polypeptide binding]; other site 768670007014 ATP/Mg binding site [chemical binding]; other site 768670007015 stacking interactions; other site 768670007016 hinge regions; other site 768670007017 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 768670007018 oligomerisation interface [polypeptide binding]; other site 768670007019 mobile loop; other site 768670007020 roof hairpin; other site 768670007021 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 768670007022 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 768670007023 substrate binding site [chemical binding]; other site 768670007024 ligand binding site [chemical binding]; other site 768670007025 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 768670007026 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 768670007027 substrate binding site [chemical binding]; other site 768670007028 Uncharacterized protein family, UPF0114; Region: UPF0114; pfam03350 768670007029 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 768670007030 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 768670007031 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 768670007032 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 768670007033 Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729 768670007034 GTP1/OBG; Region: GTP1_OBG; pfam01018 768670007035 Obg GTPase; Region: Obg; cd01898 768670007036 G1 box; other site 768670007037 GTP/Mg2+ binding site [chemical binding]; other site 768670007038 Switch I region; other site 768670007039 G2 box; other site 768670007040 G3 box; other site 768670007041 Switch II region; other site 768670007042 G4 box; other site 768670007043 G5 box; other site 768670007044 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 768670007045 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 768670007046 response regulator PleD; Reviewed; Region: pleD; PRK09581 768670007047 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768670007048 active site 768670007049 phosphorylation site [posttranslational modification] 768670007050 intermolecular recognition site; other site 768670007051 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768670007052 active site 768670007053 phosphorylation site [posttranslational modification] 768670007054 intermolecular recognition site; other site 768670007055 dimerization interface [polypeptide binding]; other site 768670007056 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 768670007057 metal binding site [ion binding]; metal-binding site 768670007058 active site 768670007059 I-site; other site 768670007060 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 768670007061 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 768670007062 HIGH motif; other site 768670007063 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 768670007064 active site 768670007065 KMSKS motif; other site 768670007066 GTP-binding protein Der; Reviewed; Region: PRK00093 768670007067 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 768670007068 G1 box; other site 768670007069 GTP/Mg2+ binding site [chemical binding]; other site 768670007070 Switch I region; other site 768670007071 G2 box; other site 768670007072 Switch II region; other site 768670007073 G3 box; other site 768670007074 G4 box; other site 768670007075 G5 box; other site 768670007076 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 768670007077 G1 box; other site 768670007078 GTP/Mg2+ binding site [chemical binding]; other site 768670007079 Switch I region; other site 768670007080 G2 box; other site 768670007081 G3 box; other site 768670007082 Switch II region; other site 768670007083 G4 box; other site 768670007084 G5 box; other site 768670007085 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 768670007086 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 768670007087 pyridoxal 5'-phosphate binding site [chemical binding]; other site 768670007088 homodimer interface [polypeptide binding]; other site 768670007089 catalytic residue [active] 768670007090 putative transporter; Provisional; Region: PRK11660 768670007091 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 768670007092 Sulfate transporter family; Region: Sulfate_transp; pfam00916 768670007093 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 768670007094 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 768670007095 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 768670007096 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 768670007097 phosphoglyceromutase; Provisional; Region: PRK05434 768670007098 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 768670007099 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 768670007100 active site 768670007101 phosphorylation site [posttranslational modification] 768670007102 intermolecular recognition site; other site 768670007103 dimerization interface [polypeptide binding]; other site 768670007104 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768670007105 dimer interface [polypeptide binding]; other site 768670007106 phosphorylation site [posttranslational modification] 768670007107 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768670007108 ATP binding site [chemical binding]; other site 768670007109 Mg2+ binding site [ion binding]; other site 768670007110 G-X-G motif; other site 768670007111 pyruvate phosphate dikinase; Provisional; Region: PRK09279 768670007112 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 768670007113 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 768670007114 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 768670007115 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 768670007116 DALR anticodon binding domain; Region: DALR_1; pfam05746 768670007117 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 768670007118 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 768670007119 FeS/SAM binding site; other site 768670007120 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 768670007121 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 768670007122 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 768670007123 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 768670007124 dimer interface [polypeptide binding]; other site 768670007125 phosphorylation site [posttranslational modification] 768670007126 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 768670007127 ATP binding site [chemical binding]; other site 768670007128 Mg2+ binding site [ion binding]; other site 768670007129 G-X-G motif; other site 768670007130 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 768670007131 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 768670007132 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 768670007133 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 768670007134 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 768670007135 AMIN domain; Region: AMIN; pfam11741 768670007136 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 768670007137 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 768670007138 active site 768670007139 metal binding site [ion binding]; metal-binding site 768670007140 Family of unknown function (DUF490); Region: DUF490; pfam04357 768670007141 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 768670007142 Surface antigen; Region: Bac_surface_Ag; pfam01103 768670007143 Uncharacterized ACR, YagE family COG1723; Region: DUF155; cl00751 768670007144 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 768670007145 Ferritin-like domain; Region: Ferritin; pfam00210 768670007146 heme binding site [chemical binding]; other site 768670007147 ferroxidase pore; other site 768670007148 ferroxidase diiron center [ion binding]; other site