-- dump date   	20140619_020406
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
632348000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
632348000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
632348000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
632348000004	Walker A motif; other site
632348000005	ATP binding site [chemical binding]; other site
632348000006	Walker B motif; other site
632348000007	arginine finger; other site
632348000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
632348000009	DnaA box-binding interface [nucleotide binding]; other site
632348000010	DNA polymerase III subunit beta; Validated; Region: PRK05643
632348000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
632348000012	putative DNA binding surface [nucleotide binding]; other site
632348000013	dimer interface [polypeptide binding]; other site
632348000014	beta-clamp/clamp loader binding surface; other site
632348000015	beta-clamp/translesion DNA polymerase binding surface; other site
632348000016	recombination protein F; Reviewed; Region: recF; PRK00064
632348000017	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
632348000018	Walker A/P-loop; other site
632348000019	ATP binding site [chemical binding]; other site
632348000020	Q-loop/lid; other site
632348000021	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
632348000022	ABC transporter signature motif; other site
632348000023	Walker B; other site
632348000024	D-loop; other site
632348000025	H-loop/switch region; other site
632348000026	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
632348000027	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
632348000028	ATP binding site [chemical binding]; other site
632348000029	Mg2+ binding site [ion binding]; other site
632348000030	G-X-G motif; other site
632348000031	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
632348000032	anchoring element; other site
632348000033	dimer interface [polypeptide binding]; other site
632348000034	ATP binding site [chemical binding]; other site
632348000035	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
632348000036	active site
632348000037	putative metal-binding site [ion binding]; other site
632348000038	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
632348000039	Protein of unknown function (DUF2281); Region: DUF2281; cl02355
632348000040	Fic/DOC family; Region: Fic; cl00960
632348000041	DNA gyrase subunit A; Validated; Region: PRK05560
632348000042	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
632348000043	CAP-like domain; other site
632348000044	active site
632348000045	primary dimer interface [polypeptide binding]; other site
632348000046	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
632348000047	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
632348000048	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
632348000049	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
632348000050	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
632348000051	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
632348000052	Beta propeller domain; Region: Beta_propel; pfam09826
632348000053	S-layer homology domain; Region: SLH; pfam00395
632348000054	S-layer homology domain; Region: SLH; pfam00395
632348000055	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
632348000056	Interdomain contacts; other site
632348000057	Cytokine receptor motif; other site
632348000058	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
632348000059	metal ion-dependent adhesion site (MIDAS); other site
632348000060	Bacterial SH3 domain; Region: SH3_3; pfam08239
632348000061	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
632348000062	RHS Repeat; Region: RHS_repeat; pfam05593
632348000063	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
632348000064	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
632348000065	RHS Repeat; Region: RHS_repeat; pfam05593
632348000066	RHS Repeat; Region: RHS_repeat; pfam05593
632348000067	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
632348000068	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
632348000069	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
632348000070	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
632348000071	RHS Repeat; Region: RHS_repeat; pfam05593
632348000072	RHS Repeat; Region: RHS_repeat; pfam05593
632348000073	RHS Repeat; Region: RHS_repeat; pfam05593
632348000074	RHS Repeat; Region: RHS_repeat; pfam05593
632348000075	RHS Repeat; Region: RHS_repeat; pfam05593
632348000076	RHS Repeat; Region: RHS_repeat; pfam05593
632348000077	RHS Repeat; Region: RHS_repeat; pfam05593
632348000078	RHS Repeat; Region: RHS_repeat; pfam05593
632348000079	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
632348000080	RHS Repeat; Region: RHS_repeat; pfam05593
632348000081	RHS Repeat; Region: RHS_repeat; pfam05593
632348000082	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
632348000083	RHS Repeat; Region: RHS_repeat; pfam05593
632348000084	RHS Repeat; Region: RHS_repeat; pfam05593
632348000085	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
632348000086	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
632348000087	Family description; Region: UvrD_C_2; pfam13538
632348000088	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
632348000089	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588
632348000090	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
632348000091	Catalytic site [active]
632348000092	peroxiredoxin; Provisional; Region: PRK13189
632348000093	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
632348000094	dimer interface [polypeptide binding]; other site
632348000095	decamer (pentamer of dimers) interface [polypeptide binding]; other site
632348000096	catalytic triad [active]
632348000097	Part of AAA domain; Region: AAA_19; pfam13245
632348000098	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
632348000099	Family description; Region: UvrD_C_2; pfam13538
632348000100	Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117
632348000101	PLD-like domain; Region: PLDc_2; pfam13091
632348000102	homodimer interface [polypeptide binding]; other site
632348000103	putative active site [active]
632348000104	catalytic site [active]
632348000105	hypothetical protein; Provisional; Region: PRK13795
632348000106	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
632348000107	Active Sites [active]
632348000108	Ferredoxin [Energy production and conversion]; Region: COG1146
632348000109	Protein of unknown function (DUF4007); Region: DUF4007; pfam13182
632348000110	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
632348000111	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
632348000112	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
632348000113	catalytic residue [active]
632348000114	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_a; cd09179
632348000115	putative active site [active]
632348000116	catalytic site [active]
632348000117	DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095
632348000118	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
632348000119	ATP binding site [chemical binding]; other site
632348000120	putative Mg++ binding site [ion binding]; other site
632348000121	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
632348000122	nucleotide binding region [chemical binding]; other site
632348000123	ATP-binding site [chemical binding]; other site
632348000124	Protein of unknown function DUF262; Region: DUF262; pfam03235
632348000125	Uncharacterized conserved protein [Function unknown]; Region: COG3472
632348000126	KWG Leptospira; Region: KWG; pfam07656
632348000127	LemA family; Region: LemA; pfam04011
632348000128	Repair protein; Region: Repair_PSII; pfam04536
632348000129	Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515
632348000130	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
632348000131	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
632348000132	GDP-binding site [chemical binding]; other site
632348000133	ACT binding site; other site
632348000134	IMP binding site; other site
632348000135	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
632348000136	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
632348000137	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
632348000138	Walker A/P-loop; other site
632348000139	ATP binding site [chemical binding]; other site
632348000140	Q-loop/lid; other site
632348000141	ABC transporter signature motif; other site
632348000142	Walker B; other site
632348000143	D-loop; other site
632348000144	H-loop/switch region; other site
632348000145	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
632348000146	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
632348000147	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
632348000148	Walker A/P-loop; other site
632348000149	ATP binding site [chemical binding]; other site
632348000150	Q-loop/lid; other site
632348000151	ABC transporter signature motif; other site
632348000152	Walker B; other site
632348000153	D-loop; other site
632348000154	H-loop/switch region; other site
632348000155	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
632348000156	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
632348000157	active site
632348000158	catalytic tetrad [active]
632348000159	Integral membrane protein DUF95; Region: DUF95; pfam01944
632348000160	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
632348000161	Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483
632348000162	O-Antigen ligase; Region: Wzy_C; pfam04932
632348000163	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
632348000164	O-Antigen ligase; Region: Wzy_C; cl04850
632348000165	TPR repeat; Region: TPR_11; pfam13414
632348000166	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
632348000167	TPR motif; other site
632348000168	Tetratricopeptide repeat; Region: TPR_12; pfam13424
632348000169	binding surface
632348000170	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
632348000171	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
632348000172	putative ADP-binding pocket [chemical binding]; other site
632348000173	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
632348000174	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
632348000175	active site
632348000176	O-Antigen ligase; Region: Wzy_C; pfam04932
632348000177	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
632348000178	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
632348000179	active site
632348000180	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
632348000181	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
632348000182	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
632348000183	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
632348000184	UDP-galactopyranose mutase; Region: GLF; pfam03275
632348000185	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
632348000186	Bacterial sugar transferase; Region: Bac_transf; pfam02397
632348000187	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
632348000188	Macro domain, Af1521- and BAL-like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Af1521_BAL_like; cd02907
632348000189	ADP-ribose binding site [chemical binding]; other site
632348000190	CTP synthetase; Validated; Region: pyrG; PRK05380
632348000191	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
632348000192	Catalytic site [active]
632348000193	active site
632348000194	UTP binding site [chemical binding]; other site
632348000195	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
632348000196	active site
632348000197	putative oxyanion hole; other site
632348000198	catalytic triad [active]
632348000199	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
632348000200	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632348000201	active site
632348000202	phosphorylation site [posttranslational modification]
632348000203	intermolecular recognition site; other site
632348000204	dimerization interface [polypeptide binding]; other site
632348000205	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
632348000206	DNA binding site [nucleotide binding]
632348000207	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
632348000208	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
632348000209	dimerization interface [polypeptide binding]; other site
632348000210	PAS domain; Region: PAS; smart00091
632348000211	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
632348000212	dimer interface [polypeptide binding]; other site
632348000213	phosphorylation site [posttranslational modification]
632348000214	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
632348000215	ATP binding site [chemical binding]; other site
632348000216	Mg2+ binding site [ion binding]; other site
632348000217	G-X-G motif; other site
632348000218	YycH protein; Region: YycI; cl02015
632348000219	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
632348000220	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632348000221	dimer interface [polypeptide binding]; other site
632348000222	conserved gate region; other site
632348000223	ABC-ATPase subunit interface; other site
632348000224	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
632348000225	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632348000226	dimer interface [polypeptide binding]; other site
632348000227	conserved gate region; other site
632348000228	putative PBP binding loops; other site
632348000229	ABC-ATPase subunit interface; other site
632348000230	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
632348000231	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
632348000232	dimerization interface [polypeptide binding]; other site
632348000233	Histidine kinase; Region: His_kinase; pfam06580
632348000234	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
632348000235	ATP binding site [chemical binding]; other site
632348000236	Mg2+ binding site [ion binding]; other site
632348000237	G-X-G motif; other site
632348000238	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
632348000239	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632348000240	active site
632348000241	phosphorylation site [posttranslational modification]
632348000242	intermolecular recognition site; other site
632348000243	dimerization interface [polypeptide binding]; other site
632348000244	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632348000245	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632348000246	S-layer homology domain; Region: SLH; pfam00395
632348000247	S-layer homology domain; Region: SLH; pfam00395
632348000248	Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273
632348000249	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
632348000250	active site
632348000251	catalytic residues [active]
632348000252	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
632348000253	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
632348000254	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
632348000255	putative metal binding site [ion binding]; other site
632348000256	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
632348000257	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
632348000258	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
632348000259	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
632348000260	dimerization interface [polypeptide binding]; other site
632348000261	Histidine kinase; Region: His_kinase; pfam06580
632348000262	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
632348000263	ATP binding site [chemical binding]; other site
632348000264	Mg2+ binding site [ion binding]; other site
632348000265	G-X-G motif; other site
632348000266	Response regulator receiver domain; Region: Response_reg; pfam00072
632348000267	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632348000268	active site
632348000269	phosphorylation site [posttranslational modification]
632348000270	intermolecular recognition site; other site
632348000271	dimerization interface [polypeptide binding]; other site
632348000272	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632348000273	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
632348000274	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632348000275	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
632348000276	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
632348000277	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632348000278	dimer interface [polypeptide binding]; other site
632348000279	conserved gate region; other site
632348000280	putative PBP binding loops; other site
632348000281	ABC-ATPase subunit interface; other site
632348000282	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
632348000283	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632348000284	dimer interface [polypeptide binding]; other site
632348000285	conserved gate region; other site
632348000286	putative PBP binding loops; other site
632348000287	ABC-ATPase subunit interface; other site
632348000288	Glycosyl hydrolase family 81; Region: Glyco_hydro_81; cl02310
632348000289	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
632348000290	Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231
632348000291	sugar binding site [chemical binding]; other site
632348000292	Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457
632348000293	Carbohydrate Binding Module families 36 (CBM36) and 6 (CBM6); appended mainly to glycoside hydrolase family 11 (GH11) domains; xylan binding; Region: CBM6_36_xylanase-like; cd04078
632348000294	Ca binding site [ion binding]; other site
632348000295	Ca binding site (active) [ion binding]; other site
632348000296	ligand binding site [chemical binding]; other site
632348000297	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
632348000298	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
632348000299	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
632348000300	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632348000301	dimer interface [polypeptide binding]; other site
632348000302	conserved gate region; other site
632348000303	putative PBP binding loops; other site
632348000304	ABC-ATPase subunit interface; other site
632348000305	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
632348000306	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632348000307	dimer interface [polypeptide binding]; other site
632348000308	conserved gate region; other site
632348000309	putative PBP binding loops; other site
632348000310	ABC-ATPase subunit interface; other site
632348000311	maltose phosphorylase; Provisional; Region: PRK13807
632348000312	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
632348000313	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
632348000314	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
632348000315	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
632348000316	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
632348000317	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
632348000318	beta-phosphoglucomutase; Region: bPGM; TIGR01990
632348000319	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
632348000320	motif II; other site
632348000321	S-layer homology domain; Region: SLH; pfam00395
632348000322	S-layer homology domain; Region: SLH; pfam00395
632348000323	S-layer homology domain; Region: SLH; pfam00395
632348000324	CARDB; Region: CARDB; pfam07705
632348000325	CARDB; Region: CARDB; pfam07705
632348000326	DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_4; cd09619
632348000327	putative ligand binding site [chemical binding]; other site
632348000328	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
632348000329	putative metal binding site [ion binding]; other site
632348000330	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
632348000331	Right handed beta helix region; Region: Beta_helix; pfam13229
632348000332	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
632348000333	HAMP domain; Region: HAMP; pfam00672
632348000334	Histidine kinase; Region: His_kinase; pfam06580
632348000335	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
632348000336	ATP binding site [chemical binding]; other site
632348000337	Mg2+ binding site [ion binding]; other site
632348000338	G-X-G motif; other site
632348000339	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632348000340	Response regulator receiver domain; Region: Response_reg; pfam00072
632348000341	active site
632348000342	phosphorylation site [posttranslational modification]
632348000343	intermolecular recognition site; other site
632348000344	dimerization interface [polypeptide binding]; other site
632348000345	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632348000346	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
632348000347	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632348000348	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
632348000349	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
632348000350	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632348000351	dimer interface [polypeptide binding]; other site
632348000352	conserved gate region; other site
632348000353	putative PBP binding loops; other site
632348000354	ABC-ATPase subunit interface; other site
632348000355	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
632348000356	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632348000357	dimer interface [polypeptide binding]; other site
632348000358	conserved gate region; other site
632348000359	putative PBP binding loops; other site
632348000360	ABC-ATPase subunit interface; other site
632348000361	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
632348000362	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
632348000363	dimer interface [polypeptide binding]; other site
632348000364	active site
632348000365	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
632348000366	dimer interface [polypeptide binding]; other site
632348000367	active site
632348000368	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632348000369	Response regulator receiver domain; Region: Response_reg; pfam00072
632348000370	active site
632348000371	phosphorylation site [posttranslational modification]
632348000372	intermolecular recognition site; other site
632348000373	dimerization interface [polypeptide binding]; other site
632348000374	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
632348000375	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632348000376	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
632348000377	dimerization interface [polypeptide binding]; other site
632348000378	Histidine kinase; Region: His_kinase; pfam06580
632348000379	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
632348000380	ATP binding site [chemical binding]; other site
632348000381	Mg2+ binding site [ion binding]; other site
632348000382	G-X-G motif; other site
632348000383	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
632348000384	This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800
632348000385	active site
632348000386	substrate binding site [chemical binding]; other site
632348000387	metal binding site [ion binding]; metal-binding site
632348000388	N-terminal domain of chitobiose phosphorylase (ChBP) and similar proteins; Region: GH94N_ChBP_like; cd11755
632348000389	catalytic domain interface [polypeptide binding]; other site
632348000390	putative homodimer interface [polypeptide binding]; other site
632348000391	Protein of unknown function, DUF608; Region: DUF608; pfam04685
632348000392	Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527
632348000393	Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552
632348000394	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
632348000395	Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA  is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565
632348000396	putative active site [active]
632348000397	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
632348000398	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
632348000399	active site
632348000400	dimer interface [polypeptide binding]; other site
632348000401	Response regulator receiver domain; Region: Response_reg; pfam00072
632348000402	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632348000403	active site
632348000404	phosphorylation site [posttranslational modification]
632348000405	intermolecular recognition site; other site
632348000406	dimerization interface [polypeptide binding]; other site
632348000407	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
632348000408	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632348000409	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
632348000410	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
632348000411	dimerization interface [polypeptide binding]; other site
632348000412	Histidine kinase; Region: His_kinase; pfam06580
632348000413	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
632348000414	ATP binding site [chemical binding]; other site
632348000415	Mg2+ binding site [ion binding]; other site
632348000416	G-X-G motif; other site
632348000417	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
632348000418	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
632348000419	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632348000420	dimer interface [polypeptide binding]; other site
632348000421	conserved gate region; other site
632348000422	putative PBP binding loops; other site
632348000423	ABC-ATPase subunit interface; other site
632348000424	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
632348000425	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632348000426	dimer interface [polypeptide binding]; other site
632348000427	conserved gate region; other site
632348000428	putative PBP binding loops; other site
632348000429	ABC-ATPase subunit interface; other site
632348000430	S-layer homology domain; Region: SLH; pfam00395
632348000431	S-layer homology domain; Region: SLH; pfam00395
632348000432	S-layer homology domain; Region: SLH; pfam00395
632348000433	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
632348000434	Interdomain contacts; other site
632348000435	Cytokine receptor motif; other site
632348000436	Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273
632348000437	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
632348000438	active site
632348000439	catalytic residues [active]
632348000440	Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed;  identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187
632348000441	PKC phosphorylation site [posttranslational modification]; other site
632348000442	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
632348000443	Interdomain contacts; other site
632348000444	Cytokine receptor motif; other site
632348000445	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
632348000446	Interdomain contacts; other site
632348000447	Cytokine receptor motif; other site
632348000448	Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed;  identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187
632348000449	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
632348000450	Interdomain contacts; other site
632348000451	Cytokine receptor motif; other site
632348000452	Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174
632348000453	Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231
632348000454	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
632348000455	sugar binding site [chemical binding]; other site
632348000456	Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174
632348000457	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
632348000458	Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231
632348000459	sugar binding site [chemical binding]; other site
632348000460	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
632348000461	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
632348000462	DNA binding residues [nucleotide binding]
632348000463	dimerization interface [polypeptide binding]; other site
632348000464	Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231
632348000465	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
632348000466	sugar binding site [chemical binding]; other site
632348000467	Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231
632348000468	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
632348000469	sugar binding site [chemical binding]; other site
632348000470	Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174
632348000471	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
632348000472	Interdomain contacts; other site
632348000473	Cytokine receptor motif; other site
632348000474	Fn3 associated; Region: Fn3_assoc; pfam13287
632348000475	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
632348000476	sugar binding site [chemical binding]; other site
632348000477	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
632348000478	sugar binding site [chemical binding]; other site
632348000479	Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231
632348000480	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
632348000481	sugar binding site [chemical binding]; other site
632348000482	Glycosyl hydrolase family 81; Region: Glyco_hydro_81; cl02310
632348000483	Carbohydrate Binding Module 6 (CBM6); appended to glycoside hydrolase (GH) domains, including GH5 (cellulase); Region: CBM6_cellulase-like; cd04080
632348000484	Ca binding site [ion binding]; other site
632348000485	ligand binding site I [chemical binding]; other site
632348000486	homodimer interface [polypeptide binding]; other site
632348000487	ligand binding site II [chemical binding]; other site
632348000488	Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231
632348000489	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
632348000490	sugar binding site [chemical binding]; other site
632348000491	Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231
632348000492	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
632348000493	sugar binding site [chemical binding]; other site
632348000494	Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231
632348000495	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
632348000496	sugar binding site [chemical binding]; other site
632348000497	O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520
632348000498	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
632348000499	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
632348000500	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632348000501	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
632348000502	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
632348000503	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
632348000504	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632348000505	ABC-ATPase subunit interface; other site
632348000506	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
632348000507	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632348000508	dimer interface [polypeptide binding]; other site
632348000509	conserved gate region; other site
632348000510	putative PBP binding loops; other site
632348000511	ABC-ATPase subunit interface; other site
632348000512	beta-D-glucuronidase; Provisional; Region: PRK10150
632348000513	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
632348000514	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
632348000515	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
632348000516	S-layer homology domain; Region: SLH; pfam00395
632348000517	S-layer homology domain; Region: SLH; pfam00395
632348000518	S-layer homology domain; Region: SLH; pfam00395
632348000519	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
632348000520	Interdomain contacts; other site
632348000521	Cytokine receptor motif; other site
632348000522	Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273
632348000523	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
632348000524	active site
632348000525	catalytic residues [active]
632348000526	Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed;  identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cd00257
632348000527	PKC phosphorylation site [posttranslational modification]; other site
632348000528	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
632348000529	Interdomain contacts; other site
632348000530	Cytokine receptor motif; other site
632348000531	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
632348000532	Interdomain contacts; other site
632348000533	Cytokine receptor motif; other site
632348000534	Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed;  identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187
632348000535	PKC phosphorylation site [posttranslational modification]; other site
632348000536	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
632348000537	Interdomain contacts; other site
632348000538	Cytokine receptor motif; other site
632348000539	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
632348000540	Cytokine receptor motif; other site
632348000541	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
632348000542	Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174
632348000543	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
632348000544	Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231
632348000545	sugar binding site [chemical binding]; other site
632348000546	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
632348000547	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
632348000548	active site
632348000549	zinc binding site [ion binding]; other site
632348000550	Protein of unknown function DUF72; Region: DUF72; pfam01904
632348000551	D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355
632348000552	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
632348000553	putative ligand binding site [chemical binding]; other site
632348000554	Response regulator receiver domain; Region: Response_reg; pfam00072
632348000555	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632348000556	active site
632348000557	phosphorylation site [posttranslational modification]
632348000558	intermolecular recognition site; other site
632348000559	dimerization interface [polypeptide binding]; other site
632348000560	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632348000561	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
632348000562	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632348000563	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
632348000564	dimerization interface [polypeptide binding]; other site
632348000565	Histidine kinase; Region: His_kinase; pfam06580
632348000566	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
632348000567	ATP binding site [chemical binding]; other site
632348000568	Mg2+ binding site [ion binding]; other site
632348000569	G-X-G motif; other site
632348000570	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
632348000571	D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355
632348000572	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
632348000573	putative ligand binding site [chemical binding]; other site
632348000574	xylose transporter ATP-binding subunit; Provisional; Region: PRK13549
632348000575	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
632348000576	Walker A/P-loop; other site
632348000577	ATP binding site [chemical binding]; other site
632348000578	Q-loop/lid; other site
632348000579	ABC transporter signature motif; other site
632348000580	Walker B; other site
632348000581	D-loop; other site
632348000582	H-loop/switch region; other site
632348000583	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
632348000584	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
632348000585	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
632348000586	TM-ABC transporter signature motif; other site
632348000587	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
632348000588	dimerization interface [polypeptide binding]; other site
632348000589	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
632348000590	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
632348000591	dimer interface [polypeptide binding]; other site
632348000592	putative CheW interface [polypeptide binding]; other site
632348000593	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
632348000594	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
632348000595	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
632348000596	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
632348000597	Walker A/P-loop; other site
632348000598	ATP binding site [chemical binding]; other site
632348000599	Q-loop/lid; other site
632348000600	ABC transporter signature motif; other site
632348000601	Walker B; other site
632348000602	D-loop; other site
632348000603	H-loop/switch region; other site
632348000604	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
632348000605	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
632348000606	Walker A/P-loop; other site
632348000607	ATP binding site [chemical binding]; other site
632348000608	Q-loop/lid; other site
632348000609	ABC transporter signature motif; other site
632348000610	Walker B; other site
632348000611	D-loop; other site
632348000612	H-loop/switch region; other site
632348000613	Predicted transcriptional regulators [Transcription]; Region: COG1725
632348000614	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
632348000615	DNA-binding site [nucleotide binding]; DNA binding site
632348000616	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
632348000617	nucleoside/Zn binding site; other site
632348000618	dimer interface [polypeptide binding]; other site
632348000619	catalytic motif [active]
632348000620	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
632348000621	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
632348000622	ATP binding site [chemical binding]; other site
632348000623	Mg2+ binding site [ion binding]; other site
632348000624	G-X-G motif; other site
632348000625	Pectinesterase; Region: Pectinesterase; pfam01095
632348000626	putative pectinesterase; Region: PLN02432; cl01911
632348000627	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
632348000628	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
632348000629	putative DNA binding site [nucleotide binding]; other site
632348000630	putative Zn2+ binding site [ion binding]; other site
632348000631	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
632348000632	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
632348000633	uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804
632348000634	N- and C-terminal domain interface [polypeptide binding]; other site
632348000635	putative active site [active]
632348000636	MgATP binding site [chemical binding]; other site
632348000637	catalytic site [active]
632348000638	metal binding site [ion binding]; metal-binding site
632348000639	putative xylulose binding site [chemical binding]; other site
632348000640	putative homodimer interface [polypeptide binding]; other site
632348000641	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
632348000642	intersubunit interface [polypeptide binding]; other site
632348000643	active site
632348000644	zinc binding site [ion binding]; other site
632348000645	Na+ binding site [ion binding]; other site
632348000646	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
632348000647	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
632348000648	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
632348000649	glyoxylate reductase; Reviewed; Region: PRK13243
632348000650	dimerization interface [polypeptide binding]; other site
632348000651	ligand binding site [chemical binding]; other site
632348000652	NADP binding site [chemical binding]; other site
632348000653	catalytic site [active]
632348000654	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
632348000655	Transcriptional regulator [Transcription]; Region: IclR; COG1414
632348000656	Bacterial transcriptional regulator; Region: IclR; pfam01614
632348000657	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
632348000658	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
632348000659	active site
632348000660	intersubunit interface [polypeptide binding]; other site
632348000661	catalytic residue [active]
632348000662	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
632348000663	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
632348000664	substrate binding site [chemical binding]; other site
632348000665	ATP binding site [chemical binding]; other site
632348000666	5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924
632348000667	2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832
632348000668	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
632348000669	NADP binding site [chemical binding]; other site
632348000670	homodimer interface [polypeptide binding]; other site
632348000671	active site
632348000672	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
632348000673	Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225
632348000674	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
632348000675	Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295
632348000676	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
632348000677	Interdomain contacts; other site
632348000678	Cytokine receptor motif; other site
632348000679	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
632348000680	Interdomain contacts; other site
632348000681	Cytokine receptor motif; other site
632348000682	Pectate lyase; Region: Pec_lyase_C; cl01593
632348000683	Pectinesterase; Region: Pectinesterase; pfam01095
632348000684	putative pectinesterase; Region: PLN02432; cl01911
632348000685	MG2 domain; Region: A2M_N; pfam01835
632348000686	S-layer homology domain; Region: SLH; pfam00395
632348000687	S-layer homology domain; Region: SLH; pfam00395
632348000688	S-layer homology domain; Region: SLH; pfam00395
632348000689	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
632348000690	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
632348000691	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001
632348000692	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
632348000693	active site
632348000694	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
632348000695	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
632348000696	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
632348000697	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632348000698	dimer interface [polypeptide binding]; other site
632348000699	conserved gate region; other site
632348000700	putative PBP binding loops; other site
632348000701	ABC-ATPase subunit interface; other site
632348000702	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
632348000703	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632348000704	dimer interface [polypeptide binding]; other site
632348000705	conserved gate region; other site
632348000706	putative PBP binding loops; other site
632348000707	ABC-ATPase subunit interface; other site
632348000708	Response regulator receiver domain; Region: Response_reg; pfam00072
632348000709	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632348000710	active site
632348000711	phosphorylation site [posttranslational modification]
632348000712	intermolecular recognition site; other site
632348000713	dimerization interface [polypeptide binding]; other site
632348000714	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
632348000715	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632348000716	Histidine kinase; Region: His_kinase; pfam06580
632348000717	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
632348000718	ATP binding site [chemical binding]; other site
632348000719	Mg2+ binding site [ion binding]; other site
632348000720	G-X-G motif; other site
632348000721	Glycosyl hydrolase family 43; Region: GH43_2; cd08981
632348000722	active site
632348000723	cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340
632348000724	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
632348000725	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
632348000726	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
632348000727	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
632348000728	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
632348000729	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
632348000730	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
632348000731	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
632348000732	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
632348000733	gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522
632348000734	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
632348000735	Walker A/P-loop; other site
632348000736	ATP binding site [chemical binding]; other site
632348000737	Q-loop/lid; other site
632348000738	ABC transporter signature motif; other site
632348000739	Walker B; other site
632348000740	D-loop; other site
632348000741	H-loop/switch region; other site
632348000742	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
632348000743	Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530
632348000744	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
632348000745	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
632348000746	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
632348000747	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
632348000748	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
632348000749	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
632348000750	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
632348000751	Cupin domain; Region: Cupin_2; pfam07883
632348000752	Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067
632348000753	Glutamine amidotransferases class-II (Gn-AT)_GlxB-type.  GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907
632348000754	putative active site [active]
632348000755	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
632348000756	4Fe-4S binding domain; Region: Fer4; pfam00037
632348000757	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
632348000758	Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645
632348000759	active site
632348000760	FMN binding site [chemical binding]; other site
632348000761	substrate binding site [chemical binding]; other site
632348000762	3Fe-4S cluster binding site [ion binding]; other site
632348000763	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
632348000764	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
632348000765	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
632348000766	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
632348000767	Archaeal-type gltB domain. This domain shares sequence similarity with a region of unknown function found in the large subunit of glutamate synthase, which is encoded by gltB and found in most bacteria and eukaryotes. It is predicted to be homologous to...; Region: arch_gltB; cd00981
632348000768	putative subunit interface; other site
632348000769	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
632348000770	Zn2+ binding site [ion binding]; other site
632348000771	Mg2+ binding site [ion binding]; other site
632348000772	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
632348000773	L-lactate permease; Region: Lactate_perm; cl00701
632348000774	Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782
632348000775	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
632348000776	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
632348000777	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
632348000778	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
632348000779	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
632348000780	Fanconi anemia ID complex proteins FANCI and FANCD2; Region: FANC; cl17018
632348000781	ubiquitination site [posttranslational modification]; other site
632348000782	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
632348000783	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
632348000784	FeS/SAM binding site; other site
632348000785	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
632348000786	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
632348000787	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
632348000788	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
632348000789	Walker A/P-loop; other site
632348000790	ATP binding site [chemical binding]; other site
632348000791	Q-loop/lid; other site
632348000792	ABC transporter signature motif; other site
632348000793	Walker B; other site
632348000794	D-loop; other site
632348000795	H-loop/switch region; other site
632348000796	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
632348000797	E3 interaction surface; other site
632348000798	lipoyl attachment site [posttranslational modification]; other site
632348000799	HlyD family secretion protein; Region: HlyD_3; pfam13437
632348000800	HlyD family secretion protein; Region: HlyD_2; pfam12700
632348000801	HlyD family secretion protein; Region: HlyD_3; pfam13437
632348000802	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
632348000803	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
632348000804	FtsX-like permease family; Region: FtsX; pfam02687
632348000805	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
632348000806	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
632348000807	Walker A/P-loop; other site
632348000808	ATP binding site [chemical binding]; other site
632348000809	Q-loop/lid; other site
632348000810	ABC transporter signature motif; other site
632348000811	Walker B; other site
632348000812	D-loop; other site
632348000813	H-loop/switch region; other site
632348000814	S-layer homology domain; Region: SLH; pfam00395
632348000815	S-layer homology domain; Region: SLH; pfam00395
632348000816	Predicted transcriptional regulators [Transcription]; Region: COG1725
632348000817	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
632348000818	DNA-binding site [nucleotide binding]; DNA binding site
632348000819	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
632348000820	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
632348000821	Walker A/P-loop; other site
632348000822	ATP binding site [chemical binding]; other site
632348000823	Q-loop/lid; other site
632348000824	ABC transporter signature motif; other site
632348000825	Walker B; other site
632348000826	D-loop; other site
632348000827	H-loop/switch region; other site
632348000828	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
632348000829	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
632348000830	Walker A/P-loop; other site
632348000831	ATP binding site [chemical binding]; other site
632348000832	Q-loop/lid; other site
632348000833	ABC transporter signature motif; other site
632348000834	Walker B; other site
632348000835	D-loop; other site
632348000836	H-loop/switch region; other site
632348000837	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
632348000838	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
632348000839	TraX protein; Region: TraX; pfam05857
632348000840	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
632348000841	Probable transposase; Region: OrfB_IS605; pfam01385
632348000842	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
632348000843	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
632348000844	active site
632348000845	NTP binding site [chemical binding]; other site
632348000846	metal binding triad [ion binding]; metal-binding site
632348000847	antibiotic binding site [chemical binding]; other site
632348000848	Protein of unknown function DUF86; Region: DUF86; pfam01934
632348000849	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
632348000850	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
632348000851	FMN binding site [chemical binding]; other site
632348000852	active site
632348000853	catalytic residues [active]
632348000854	substrate binding site [chemical binding]; other site
632348000855	S-layer homology domain; Region: SLH; pfam00395
632348000856	S-layer homology domain; Region: SLH; pfam00395
632348000857	S-layer homology domain; Region: SLH; pfam00395
632348000858	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
632348000859	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
632348000860	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
632348000861	protein binding site [polypeptide binding]; other site
632348000862	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
632348000863	Catalytic dyad [active]
632348000864	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
632348000865	rod shape-determining protein Mbl; Provisional; Region: PRK13928
632348000866	MreB and similar proteins; Region: MreB_like; cd10225
632348000867	nucleotide binding site [chemical binding]; other site
632348000868	Mg binding site [ion binding]; other site
632348000869	putative protofilament interaction site [polypeptide binding]; other site
632348000870	RodZ interaction site [polypeptide binding]; other site
632348000871	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786
632348000872	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
632348000873	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
632348000874	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786
632348000875	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
632348000876	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
632348000877	Rod binding protein; Region: Rod-binding; pfam10135
632348000878	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
632348000879	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
632348000880	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
632348000881	Transposase [DNA replication, recombination, and repair]; Region: COG5421
632348000882	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
632348000883	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
632348000884	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
632348000885	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
632348000886	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
632348000887	active site
632348000888	catalytic tetrad [active]
632348000889	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
632348000890	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
632348000891	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
632348000892	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632348000893	dimer interface [polypeptide binding]; other site
632348000894	conserved gate region; other site
632348000895	putative PBP binding loops; other site
632348000896	ABC-ATPase subunit interface; other site
632348000897	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
632348000898	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632348000899	dimer interface [polypeptide binding]; other site
632348000900	conserved gate region; other site
632348000901	ABC-ATPase subunit interface; other site
632348000902	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
632348000903	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
632348000904	Helix-turn-helix domain; Region: HTH_18; pfam12833
632348000905	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632348000906	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
632348000907	TPP-binding site [chemical binding]; other site
632348000908	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
632348000909	PYR/PP interface [polypeptide binding]; other site
632348000910	dimer interface [polypeptide binding]; other site
632348000911	TPP binding site [chemical binding]; other site
632348000912	Predicted permeases [General function prediction only]; Region: COG0679
632348000913	H+ Antiporter protein; Region: 2A0121; TIGR00900
632348000914	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
632348000915	putative substrate translocation pore; other site
632348000916	Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821
632348000917	active site
632348000918	catalytic triad [active]
632348000919	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
632348000920	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
632348000921	active site
632348000922	substrate binding site [chemical binding]; other site
632348000923	metal binding site [ion binding]; metal-binding site
632348000924	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
632348000925	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
632348000926	glutaminase active site [active]
632348000927	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
632348000928	dimer interface [polypeptide binding]; other site
632348000929	active site
632348000930	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
632348000931	dimer interface [polypeptide binding]; other site
632348000932	active site
632348000933	Predicted transcriptional regulators [Transcription]; Region: COG1733
632348000934	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
632348000935	dimerization interface [polypeptide binding]; other site
632348000936	putative DNA binding site [nucleotide binding]; other site
632348000937	putative Zn2+ binding site [ion binding]; other site
632348000938	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
632348000939	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
632348000940	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
632348000941	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
632348000942	non-specific DNA binding site [nucleotide binding]; other site
632348000943	salt bridge; other site
632348000944	sequence-specific DNA binding site [nucleotide binding]; other site
632348000945	DNA polymerase IV; Reviewed; Region: PRK03103
632348000946	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
632348000947	active site
632348000948	DNA binding site [nucleotide binding]
632348000949	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
632348000950	transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765
632348000951	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
632348000952	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
632348000953	HlyD family secretion protein; Region: HlyD_3; pfam13437
632348000954	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
632348000955	carboxyltransferase (CT) interaction site; other site
632348000956	biotinylation site [posttranslational modification]; other site
632348000957	HlyD family secretion protein; Region: HlyD_3; pfam13437
632348000958	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
632348000959	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
632348000960	FtsX-like permease family; Region: FtsX; pfam02687
632348000961	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
632348000962	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
632348000963	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
632348000964	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
632348000965	Walker A/P-loop; other site
632348000966	ATP binding site [chemical binding]; other site
632348000967	Q-loop/lid; other site
632348000968	ABC transporter signature motif; other site
632348000969	Walker B; other site
632348000970	D-loop; other site
632348000971	H-loop/switch region; other site
632348000972	Protein of unknown function (DUF970); Region: DUF970; cl17525
632348000973	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
632348000974	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
632348000975	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723
632348000976	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
632348000977	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
632348000978	Histidine kinase; Region: His_kinase; pfam06580
632348000979	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
632348000980	ATP binding site [chemical binding]; other site
632348000981	Mg2+ binding site [ion binding]; other site
632348000982	G-X-G motif; other site
632348000983	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
632348000984	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632348000985	active site
632348000986	phosphorylation site [posttranslational modification]
632348000987	intermolecular recognition site; other site
632348000988	dimerization interface [polypeptide binding]; other site
632348000989	LytTr DNA-binding domain; Region: LytTR; smart00850
632348000990	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
632348000991	Carbon starvation protein CstA; Region: CstA; pfam02554
632348000992	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
632348000993	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
632348000994	active site
632348000995	substrate binding site [chemical binding]; other site
632348000996	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
632348000997	FMN binding site [chemical binding]; other site
632348000998	putative catalytic residues [active]
632348000999	Iron permease FTR1 family; Region: FTR1; cl00475
632348001000	Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547
632348001001	stage IV sporulation protein A; Region: spore_IV_A; TIGR02836
632348001002	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
632348001003	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
632348001004	Ligand Binding Site [chemical binding]; other site
632348001005	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
632348001006	Transposase; Region: DDE_Tnp_ISL3; pfam01610
632348001007	YcfA-like protein; Region: YcfA; pfam07927
632348001008	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
632348001009	spore photoproduct lyase; Region: photo_TT_lyase; cl15393
632348001010	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
632348001011	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
632348001012	Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316
632348001013	Ca binding site [ion binding]; other site
632348001014	active site
632348001015	catalytic site [active]
632348001016	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
632348001017	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
632348001018	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
632348001019	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
632348001020	S-adenosylmethionine binding site [chemical binding]; other site
632348001021	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
632348001022	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632348001023	active site
632348001024	phosphorylation site [posttranslational modification]
632348001025	intermolecular recognition site; other site
632348001026	dimerization interface [polypeptide binding]; other site
632348001027	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
632348001028	DNA binding site [nucleotide binding]
632348001029	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
632348001030	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
632348001031	dimer interface [polypeptide binding]; other site
632348001032	phosphorylation site [posttranslational modification]
632348001033	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
632348001034	ATP binding site [chemical binding]; other site
632348001035	Mg2+ binding site [ion binding]; other site
632348001036	G-X-G motif; other site
632348001037	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
632348001038	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
632348001039	FtsX-like permease family; Region: FtsX; pfam02687
632348001040	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
632348001041	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
632348001042	Walker A/P-loop; other site
632348001043	ATP binding site [chemical binding]; other site
632348001044	Q-loop/lid; other site
632348001045	ABC transporter signature motif; other site
632348001046	Walker B; other site
632348001047	D-loop; other site
632348001048	H-loop/switch region; other site
632348001049	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
632348001050	HlyD family secretion protein; Region: HlyD_3; pfam13437
632348001051	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
632348001052	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
632348001053	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
632348001054	Uncharacterized membrane protein [Function unknown]; Region: SpmB; cl17667
632348001055	Predicted cobalamin binding protein [General function prediction only]; Region: COG5012
632348001056	B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070
632348001057	B12 binding site [chemical binding]; other site
632348001058	cobalt ligand [ion binding]; other site
632348001059	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
632348001060	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596
632348001061	intersubunit interface [polypeptide binding]; other site
632348001062	active site
632348001063	Zn2+ binding site [ion binding]; other site
632348001064	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
632348001065	maltodextrin glucosidase; Provisional; Region: PRK10785
632348001066	homodimer interface [polypeptide binding]; other site
632348001067	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
632348001068	active site
632348001069	homodimer interface [polypeptide binding]; other site
632348001070	catalytic site [active]
632348001071	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632348001072	dimer interface [polypeptide binding]; other site
632348001073	conserved gate region; other site
632348001074	putative PBP binding loops; other site
632348001075	ABC-ATPase subunit interface; other site
632348001076	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
632348001077	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632348001078	dimer interface [polypeptide binding]; other site
632348001079	conserved gate region; other site
632348001080	putative PBP binding loops; other site
632348001081	ABC-ATPase subunit interface; other site
632348001082	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
632348001083	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
632348001084	Transcriptional regulators [Transcription]; Region: PurR; COG1609
632348001085	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
632348001086	DNA binding site [nucleotide binding]
632348001087	domain linker motif; other site
632348001088	Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294
632348001089	putative dimerization interface [polypeptide binding]; other site
632348001090	putative ligand binding site [chemical binding]; other site
632348001091	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
632348001092	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
632348001093	The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465
632348001094	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
632348001095	Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301
632348001096	Beta-galactosidase, domain 2; Region: BetaGal_dom2; smart01029
632348001097	Glycosyl hydrolase family 43; Region: GH43_5; cd08984
632348001098	active site
632348001099	MoxR-like ATPases [General function prediction only]; Region: COG0714
632348001100	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
632348001101	Walker A motif; other site
632348001102	ATP binding site [chemical binding]; other site
632348001103	Walker B motif; other site
632348001104	arginine finger; other site
632348001105	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
632348001106	dimer interface [polypeptide binding]; other site
632348001107	substrate binding site [chemical binding]; other site
632348001108	metal binding site [ion binding]; metal-binding site
632348001109	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
632348001110	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
632348001111	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
632348001112	Transcriptional regulators [Transcription]; Region: PurR; COG1609
632348001113	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
632348001114	DNA binding site [nucleotide binding]
632348001115	domain linker motif; other site
632348001116	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
632348001117	Domain of unknown function (DUF377); Region: DUF377; pfam04041
632348001118	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
632348001119	active site
632348001120	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
632348001121	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
632348001122	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
632348001123	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
632348001124	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632348001125	dimer interface [polypeptide binding]; other site
632348001126	conserved gate region; other site
632348001127	putative PBP binding loops; other site
632348001128	ABC-ATPase subunit interface; other site
632348001129	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
632348001130	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632348001131	dimer interface [polypeptide binding]; other site
632348001132	conserved gate region; other site
632348001133	ABC-ATPase subunit interface; other site
632348001134	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
632348001135	Histidine kinase; Region: His_kinase; pfam06580
632348001136	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
632348001137	ATP binding site [chemical binding]; other site
632348001138	Mg2+ binding site [ion binding]; other site
632348001139	G-X-G motif; other site
632348001140	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
632348001141	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632348001142	active site
632348001143	phosphorylation site [posttranslational modification]
632348001144	intermolecular recognition site; other site
632348001145	dimerization interface [polypeptide binding]; other site
632348001146	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632348001147	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
632348001148	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
632348001149	THF binding site; other site
632348001150	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
632348001151	substrate binding site [chemical binding]; other site
632348001152	THF binding site; other site
632348001153	zinc-binding site [ion binding]; other site
632348001154	Methyltransferase domain; Region: Methyltransf_31; pfam13847
632348001155	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
632348001156	S-adenosylmethionine binding site [chemical binding]; other site
632348001157	Domain of unknown function (DUF4258); Region: DUF4258; pfam14076
632348001158	antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870
632348001159	toxin interface [polypeptide binding]; other site
632348001160	Zn binding site [ion binding]; other site
632348001161	RRXRR protein; Region: RRXRR; pfam14239
632348001162	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
632348001163	active site
632348001164	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
632348001165	Protein of unknown function (DUF1021); Region: DUF1021; pfam06257
632348001166	Domain of unknown function (DUF3794); Region: DUF3794; pfam12673
632348001167	Domain of unknown function (DUF3794); Region: DUF3794; pfam12673
632348001168	Domain of unknown function (DUF3794); Region: DUF3794; pfam12673
632348001169	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
632348001170	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
632348001171	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
632348001172	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
632348001173	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
632348001174	Transcriptional regulators [Transcription]; Region: PurR; COG1609
632348001175	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
632348001176	DNA binding site [nucleotide binding]
632348001177	domain linker motif; other site
632348001178	Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284
632348001179	dimerization interface [polypeptide binding]; other site
632348001180	ligand binding site [chemical binding]; other site
632348001181	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
632348001182	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
632348001183	ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175
632348001184	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632348001185	dimer interface [polypeptide binding]; other site
632348001186	conserved gate region; other site
632348001187	putative PBP binding loops; other site
632348001188	ABC-ATPase subunit interface; other site
632348001189	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
632348001190	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632348001191	dimer interface [polypeptide binding]; other site
632348001192	conserved gate region; other site
632348001193	putative PBP binding loops; other site
632348001194	ABC-ATPase subunit interface; other site
632348001195	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
632348001196	dimerization interface [polypeptide binding]; other site
632348001197	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
632348001198	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
632348001199	dimer interface [polypeptide binding]; other site
632348001200	putative CheW interface [polypeptide binding]; other site
632348001201	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
632348001202	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
632348001203	dimer interface [polypeptide binding]; other site
632348001204	putative CheW interface [polypeptide binding]; other site
632348001205	Cache domain; Region: Cache_1; pfam02743
632348001206	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
632348001207	oxaloacetate decarboxylase; Provisional; Region: PRK12331
632348001208	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
632348001209	active site
632348001210	catalytic residues [active]
632348001211	metal binding site [ion binding]; metal-binding site
632348001212	homodimer binding site [polypeptide binding]; other site
632348001213	Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; pfam04277
632348001214	Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511
632348001215	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
632348001216	carboxyltransferase (CT) interaction site; other site
632348001217	biotinylation site [posttranslational modification]; other site
632348001218	Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883
632348001219	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
632348001220	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
632348001221	dimerization interface [polypeptide binding]; other site
632348001222	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
632348001223	dimer interface [polypeptide binding]; other site
632348001224	putative CheW interface [polypeptide binding]; other site
632348001225	S-layer homology domain; Region: SLH; pfam00395
632348001226	CopC domain; Region: CopC; cl01012
632348001227	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
632348001228	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
632348001229	E3 interaction surface; other site
632348001230	lipoyl attachment site [posttranslational modification]; other site
632348001231	HlyD family secretion protein; Region: HlyD_3; pfam13437
632348001232	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
632348001233	HlyD family secretion protein; Region: HlyD_3; pfam13437
632348001234	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
632348001235	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
632348001236	Walker A/P-loop; other site
632348001237	ATP binding site [chemical binding]; other site
632348001238	Q-loop/lid; other site
632348001239	ABC transporter signature motif; other site
632348001240	Walker B; other site
632348001241	D-loop; other site
632348001242	H-loop/switch region; other site
632348001243	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
632348001244	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
632348001245	FtsX-like permease family; Region: FtsX; pfam02687
632348001246	S-layer homology domain; Region: SLH; pfam00395
632348001247	S-layer homology domain; Region: SLH; pfam00395
632348001248	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
632348001249	putative active site [active]
632348001250	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
632348001251	Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295
632348001252	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
632348001253	tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519
632348001254	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
632348001255	S-adenosylmethionine binding site [chemical binding]; other site
632348001256	FOG: CBS domain [General function prediction only]; Region: COG0517
632348001257	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
632348001258	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
632348001259	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
632348001260	Walker A motif; other site
632348001261	This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851
632348001262	Predicted DNA-binding proteins [General function prediction only]; Region: COG1342
632348001263	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
632348001264	DNA binding residues [nucleotide binding]
632348001265	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
632348001266	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
632348001267	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
632348001268	metal-binding site [ion binding]
632348001269	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
632348001270	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
632348001271	metal-binding site [ion binding]
632348001272	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
632348001273	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
632348001274	motif II; other site
632348001275	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
632348001276	metal-binding site [ion binding]
632348001277	Protein of unknown function (DUF1646); Region: DUF1646; pfam07854
632348001278	Uncharacterized conserved protein [Function unknown]; Region: COG2445
632348001279	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
632348001280	active site
632348001281	NTP binding site [chemical binding]; other site
632348001282	metal binding triad [ion binding]; metal-binding site
632348001283	antibiotic binding site [chemical binding]; other site
632348001284	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
632348001285	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
632348001286	FeS/SAM binding site; other site
632348001287	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
632348001288	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
632348001289	Chain length determinant protein; Region: Wzz; cl15801
632348001290	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
632348001291	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
632348001292	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
632348001293	active site
632348001294	S-layer homology domain; Region: SLH; pfam00395
632348001295	S-layer homology domain; Region: SLH; pfam00395
632348001296	S-layer homology domain; Region: SLH; pfam00395
632348001297	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
632348001298	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
632348001299	NADP-binding site; other site
632348001300	homotetramer interface [polypeptide binding]; other site
632348001301	substrate binding site [chemical binding]; other site
632348001302	homodimer interface [polypeptide binding]; other site
632348001303	active site
632348001304	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
632348001305	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
632348001306	NADP binding site [chemical binding]; other site
632348001307	active site
632348001308	putative substrate binding site [chemical binding]; other site
632348001309	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
632348001310	Bacterial sugar transferase; Region: Bac_transf; pfam02397
632348001311	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
632348001312	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
632348001313	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
632348001314	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
632348001315	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
632348001316	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
632348001317	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
632348001318	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
632348001319	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
632348001320	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
632348001321	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
632348001322	active site
632348001323	NAD binding site [chemical binding]; other site
632348001324	metal binding site [ion binding]; metal-binding site
632348001325	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
632348001326	Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523
632348001327	active site
632348001328	metal-binding site
632348001329	Predicted integral membrane protein [Function unknown]; Region: COG5652
632348001330	Domain of unknown function (DUF3794); Region: DUF3794; pfam12673
632348001331	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
632348001332	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
632348001333	Walker A/P-loop; other site
632348001334	ATP binding site [chemical binding]; other site
632348001335	Q-loop/lid; other site
632348001336	ABC transporter signature motif; other site
632348001337	Walker B; other site
632348001338	D-loop; other site
632348001339	H-loop/switch region; other site
632348001340	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
632348001341	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
632348001342	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
632348001343	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
632348001344	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
632348001345	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
632348001346	Walker A/P-loop; other site
632348001347	ATP binding site [chemical binding]; other site
632348001348	Q-loop/lid; other site
632348001349	ABC transporter signature motif; other site
632348001350	Walker B; other site
632348001351	D-loop; other site
632348001352	H-loop/switch region; other site
632348001353	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
632348001354	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
632348001355	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
632348001356	TM-ABC transporter signature motif; other site
632348001357	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
632348001358	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
632348001359	ligand binding site [chemical binding]; other site
632348001360	Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782
632348001361	hypothetical protein; Provisional; Region: PRK09956
632348001362	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
632348001363	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
632348001364	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
632348001365	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
632348001366	active site
632348001367	HIGH motif; other site
632348001368	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
632348001369	active site
632348001370	KMSKS motif; other site
632348001371	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
632348001372	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
632348001373	trimer interface [polypeptide binding]; other site
632348001374	active site
632348001375	substrate binding site [chemical binding]; other site
632348001376	CoA binding site [chemical binding]; other site
632348001377	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
632348001378	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
632348001379	active site
632348001380	HIGH motif; other site
632348001381	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
632348001382	KMSKS motif; other site
632348001383	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
632348001384	tRNA binding surface [nucleotide binding]; other site
632348001385	anticodon binding site; other site
632348001386	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
632348001387	Transposase IS200 like; Region: Y1_Tnp; pfam01797
632348001388	Predicted membrane protein [Function unknown]; Region: COG2323
632348001389	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
632348001390	putative active site pocket [active]
632348001391	dimerization interface [polypeptide binding]; other site
632348001392	putative catalytic residue [active]
632348001393	Predicted transcriptional regulators [Transcription]; Region: COG1733
632348001394	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
632348001395	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
632348001396	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH1; cd08185
632348001397	putative active site [active]
632348001398	metal binding site [ion binding]; metal-binding site
632348001399	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
632348001400	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
632348001401	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
632348001402	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331
632348001403	Domon-like ligand-binding domains; Region: DOMON_like; cl14783
632348001404	putative ligand binding site [chemical binding]; other site
632348001405	DOMON-like type 9 carbohydrate binding module of xylanases; Region: CBM9_like_1; cd00005
632348001406	Ca binding site [ion binding]; other site
632348001407	carbohydrate binding site [chemical binding]; other site
632348001408	Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733
632348001409	S-layer homology domain; Region: SLH; pfam00395
632348001410	S-layer homology domain; Region: SLH; pfam00395
632348001411	Amino acid permease; Region: AA_permease_2; pfam13520
632348001412	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
632348001413	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
632348001414	Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966
632348001415	putative active site [active]
632348001416	putative metal binding site [ion binding]; other site
632348001417	Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782
632348001418	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
632348001419	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
632348001420	metal binding site [ion binding]; metal-binding site
632348001421	active site
632348001422	I-site; other site
632348001423	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
632348001424	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
632348001425	dimer interface [polypeptide binding]; other site
632348001426	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
632348001427	putative CheW interface [polypeptide binding]; other site
632348001428	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
632348001429	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
632348001430	dimer interface [polypeptide binding]; other site
632348001431	putative CheW interface [polypeptide binding]; other site
632348001432	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
632348001433	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
632348001434	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
632348001435	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
632348001436	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632348001437	active site
632348001438	phosphorylation site [posttranslational modification]
632348001439	intermolecular recognition site; other site
632348001440	dimerization interface [polypeptide binding]; other site
632348001441	CheB methylesterase; Region: CheB_methylest; pfam01339
632348001442	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
632348001443	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632348001444	active site
632348001445	phosphorylation site [posttranslational modification]
632348001446	intermolecular recognition site; other site
632348001447	dimerization interface [polypeptide binding]; other site
632348001448	Chemotaxis phosphatase CheX; Region: CheX; pfam13690
632348001449	Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406
632348001450	Chemotaxis phosphatase CheX; Region: CheX; pfam13690
632348001451	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
632348001452	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
632348001453	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
632348001454	putative binding surface; other site
632348001455	active site
632348001456	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
632348001457	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
632348001458	ATP binding site [chemical binding]; other site
632348001459	Mg2+ binding site [ion binding]; other site
632348001460	G-X-G motif; other site
632348001461	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
632348001462	ribulokinase; Provisional; Region: PRK04123
632348001463	Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781
632348001464	N- and C-terminal domain interface [polypeptide binding]; other site
632348001465	active site
632348001466	MgATP binding site [chemical binding]; other site
632348001467	catalytic site [active]
632348001468	metal binding site [ion binding]; metal-binding site
632348001469	carbohydrate binding site [chemical binding]; other site
632348001470	homodimer interface [polypeptide binding]; other site
632348001471	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
632348001472	DNA-binding site [nucleotide binding]; DNA binding site
632348001473	Transcriptional regulators [Transcription]; Region: PurR; COG1609
632348001474	Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541
632348001475	putative dimerization interface [polypeptide binding]; other site
632348001476	putative ligand binding site [chemical binding]; other site
632348001477	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
632348001478	L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557
632348001479	intersubunit interface [polypeptide binding]; other site
632348001480	active site
632348001481	Zn2+ binding site [ion binding]; other site
632348001482	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
632348001483	Clostridium kluyveri Re-citrate synthase and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_Re_CS; cd07947
632348001484	active site
632348001485	catalytic residues [active]
632348001486	metal binding site [ion binding]; metal-binding site
632348001487	Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768
632348001488	4Fe-4S binding domain; Region: Fer4; cl02805
632348001489	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
632348001490	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
632348001491	glutamine binding [chemical binding]; other site
632348001492	catalytic triad [active]
632348001493	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
632348001494	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
632348001495	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
632348001496	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
632348001497	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449
632348001498	substrate-cofactor binding pocket; other site
632348001499	homodimer interface [polypeptide binding]; other site
632348001500	pyridoxal 5'-phosphate binding site [chemical binding]; other site
632348001501	catalytic residue [active]
632348001502	4Fe-4S binding domain; Region: Fer4_5; pfam12801
632348001503	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
632348001504	FMN-binding domain; Region: FMN_bind; cl01081
632348001505	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
632348001506	ApbE family; Region: ApbE; pfam02424
632348001507	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
632348001508	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
632348001509	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
632348001510	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
632348001511	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
632348001512	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_3; cd09321
632348001513	gating phenylalanine in ion channel; other site
632348001514	Protein of unknown function (DUF1634); Region: DUF1634; cl01741
632348001515	Predicted permeases [General function prediction only]; Region: COG0730
632348001516	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
632348001517	active site 1 [active]
632348001518	active site 2 [active]
632348001519	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
632348001520	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
632348001521	Potassium binding sites [ion binding]; other site
632348001522	Cesium cation binding sites [ion binding]; other site
632348001523	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
632348001524	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
632348001525	substrate-cofactor binding pocket; other site
632348001526	pyridoxal 5'-phosphate binding site [chemical binding]; other site
632348001527	catalytic residue [active]
632348001528	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
632348001529	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
632348001530	NAD(P) binding site [chemical binding]; other site
632348001531	Transcriptional regulators [Transcription]; Region: PurR; COG1609
632348001532	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
632348001533	DNA binding site [nucleotide binding]
632348001534	domain linker motif; other site
632348001535	Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294
632348001536	putative dimerization interface [polypeptide binding]; other site
632348001537	putative ligand binding site [chemical binding]; other site
632348001538	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
632348001539	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
632348001540	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
632348001541	Predicted methyltransferases [General function prediction only]; Region: COG1568
632348001542	6-carboxyhexanoate--CoA ligase; Region: BioW; cl00625
632348001543	Uncharacterized conserved protein [Function unknown]; Region: COG0585
632348001544	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
632348001545	active site
632348001546	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
632348001547	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
632348001548	active site
632348001549	NTP binding site [chemical binding]; other site
632348001550	metal binding triad [ion binding]; metal-binding site
632348001551	antibiotic binding site [chemical binding]; other site
632348001552	Uncharacterized conserved protein [Function unknown]; Region: COG2445
632348001553	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
632348001554	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
632348001555	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
632348001556	Walker A motif; other site
632348001557	ATP binding site [chemical binding]; other site
632348001558	Walker B motif; other site
632348001559	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
632348001560	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
632348001561	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
632348001562	ABC-ATPase subunit  interface; other site
632348001563	dimer interface [polypeptide binding]; other site
632348001564	putative PBP binding regions; other site
632348001565	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
632348001566	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
632348001567	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
632348001568	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
632348001569	intersubunit interface [polypeptide binding]; other site
632348001570	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
632348001571	metal binding site 2 [ion binding]; metal-binding site
632348001572	putative DNA binding helix; other site
632348001573	metal binding site 1 [ion binding]; metal-binding site
632348001574	dimer interface [polypeptide binding]; other site
632348001575	structural Zn2+ binding site [ion binding]; other site
632348001576	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
632348001577	dimerization interface [polypeptide binding]; other site
632348001578	putative DNA binding site [nucleotide binding]; other site
632348001579	putative Zn2+ binding site [ion binding]; other site
632348001580	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
632348001581	Radical SAM superfamily; Region: Radical_SAM; pfam04055
632348001582	FeS/SAM binding site; other site
632348001583	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
632348001584	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660
632348001585	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
632348001586	hypothetical protein; Reviewed; Region: PRK09588
632348001587	DNA protecting protein DprA; Region: dprA; TIGR00732
632348001588	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
632348001589	DNA topoisomerase I; Validated; Region: PRK05582
632348001590	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
632348001591	active site
632348001592	interdomain interaction site; other site
632348001593	putative metal-binding site [ion binding]; other site
632348001594	nucleotide binding site [chemical binding]; other site
632348001595	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
632348001596	domain I; other site
632348001597	DNA binding groove [nucleotide binding]
632348001598	phosphate binding site [ion binding]; other site
632348001599	domain II; other site
632348001600	domain III; other site
632348001601	nucleotide binding site [chemical binding]; other site
632348001602	catalytic site [active]
632348001603	domain IV; other site
632348001604	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
632348001605	RNA polymerase subunit 9; Region: RPOL9; smart00661
632348001606	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
632348001607	Glucose inhibited division protein A; Region: GIDA; pfam01134
632348001608	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
632348001609	active site
632348001610	HslU subunit interaction site [polypeptide binding]; other site
632348001611	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
632348001612	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
632348001613	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
632348001614	Walker A motif; other site
632348001615	ATP binding site [chemical binding]; other site
632348001616	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
632348001617	Walker B motif; other site
632348001618	arginine finger; other site
632348001619	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
632348001620	transcriptional repressor CodY; Validated; Region: PRK04158
632348001621	CodY GAF-like domain; Region: CodY; pfam06018
632348001622	CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222
632348001623	Flagellar basal body protein [Cell motility and secretion]; Region: FlgB; COG1815
632348001624	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
632348001625	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
632348001626	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
632348001627	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
632348001628	Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049
632348001629	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
632348001630	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
632348001631	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
632348001632	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
632348001633	FliG C-terminal domain; Region: FliG_C; pfam01706
632348001634	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
632348001635	type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499
632348001636	Flagellar assembly protein FliH; Region: FliH; pfam02108
632348001637	Flagellar biosynthesis/type III secretory pathway ATPase [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliI; COG1157
632348001638	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
632348001639	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
632348001640	Walker A motif/ATP binding site; other site
632348001641	Walker B motif; other site
632348001642	Uncharacterized conserved protein [Function unknown]; Region: COG3334
632348001643	MgtE intracellular N domain; Region: MgtE_N; pfam03448
632348001644	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
632348001645	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
632348001646	FlgD Tudor-like domain; Region: FLgD_tudor; cl17881
632348001647	Protein of unknown function (DUF3766); Region: DUF3766; cl11797
632348001648	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
632348001649	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
632348001650	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
632348001651	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
632348001652	Flagellar protein (FlbD); Region: FlbD; pfam06289
632348001653	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
632348001654	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
632348001655	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
632348001656	flagellar motor switch protein; Validated; Region: PRK08119
632348001657	CheC-like family; Region: CheC; pfam04509
632348001658	CheC-like family; Region: CheC; pfam04509
632348001659	flagellar motor switch protein FliN; Region: fliN; TIGR02480
632348001660	Response regulator receiver domain; Region: Response_reg; pfam00072
632348001661	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632348001662	active site
632348001663	phosphorylation site [posttranslational modification]
632348001664	intermolecular recognition site; other site
632348001665	dimerization interface [polypeptide binding]; other site
632348001666	flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500
632348001667	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
632348001668	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
632348001669	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
632348001670	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
632348001671	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
632348001672	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
632348001673	FHIPEP family; Region: FHIPEP; pfam00771
632348001674	Flagellar GTP-binding protein [Cell motility and secretion]; Region: FlhF; COG1419
632348001675	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
632348001676	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
632348001677	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
632348001678	P-loop; other site
632348001679	Flagellar protein YcgR; Region: YcgR_2; pfam12945
632348001680	PilZ domain; Region: PilZ; pfam07238
632348001681	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
632348001682	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
632348001683	putative binding surface; other site
632348001684	active site
632348001685	P2 response regulator binding domain; Region: P2; pfam07194
632348001686	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
632348001687	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
632348001688	ATP binding site [chemical binding]; other site
632348001689	Mg2+ binding site [ion binding]; other site
632348001690	G-X-G motif; other site
632348001691	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
632348001692	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
632348001693	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
632348001694	CheC-like family; Region: CheC; pfam04509
632348001695	Chemotaxis phosphatase CheX; Region: CheX; cl15816
632348001696	CheC-like family; Region: CheC; pfam04509
632348001697	chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13488
632348001698	RNA polymerase sigma factor WhiG; Reviewed; Region: PRK06288
632348001699	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
632348001700	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
632348001701	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
632348001702	DNA binding residues [nucleotide binding]
632348001703	Protein of unknown function (DUF342); Region: DUF342; pfam03961
632348001704	Cupin domain; Region: Cupin_2; pfam07883
632348001705	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
632348001706	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632348001707	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632348001708	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
632348001709	oligomerisation interface [polypeptide binding]; other site
632348001710	mobile loop; other site
632348001711	roof hairpin; other site
632348001712	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
632348001713	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
632348001714	ring oligomerisation interface [polypeptide binding]; other site
632348001715	ATP/Mg binding site [chemical binding]; other site
632348001716	stacking interactions; other site
632348001717	hinge regions; other site
632348001718	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
632348001719	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
632348001720	active site
632348001721	motif I; other site
632348001722	motif II; other site
632348001723	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
632348001724	Uncharacterized conserved protein [Function unknown]; Region: COG2006
632348001725	Domain of unknown function (DUF362); Region: DUF362; pfam04015
632348001726	4Fe-4S binding domain; Region: Fer4_6; pfam12837
632348001727	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
632348001728	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
632348001729	Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406
632348001730	Chemotaxis phosphatase CheX; Region: CheX; pfam13690
632348001731	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
632348001732	EDD domain protein, DegV family; Region: DegV; TIGR00762
632348001733	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
632348001734	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
632348001735	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
632348001736	FeS/SAM binding site; other site
632348001737	radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
632348001738	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105
632348001739	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
632348001740	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
632348001741	homodimer interface [polypeptide binding]; other site
632348001742	oligonucleotide binding site [chemical binding]; other site
632348001743	elongation factor P; Validated; Region: PRK00529
632348001744	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
632348001745	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
632348001746	RNA binding site [nucleotide binding]; other site
632348001747	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
632348001748	RNA binding site [nucleotide binding]; other site
632348001749	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
632348001750	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
632348001751	catalytic residue [active]
632348001752	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
632348001753	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
632348001754	ligand binding site [chemical binding]; other site
632348001755	NAD binding site [chemical binding]; other site
632348001756	dimerization interface [polypeptide binding]; other site
632348001757	catalytic site [active]
632348001758	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
632348001759	putative L-serine binding site [chemical binding]; other site
632348001760	Uncharacterized conserved protein [Function unknown]; Region: COG4198
632348001761	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
632348001762	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
632348001763	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
632348001764	motif II; other site
632348001765	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
632348001766	S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124
632348001767	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
632348001768	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
632348001769	putative substrate binding site [chemical binding]; other site
632348001770	putative ATP binding site [chemical binding]; other site
632348001771	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
632348001772	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
632348001773	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
632348001774	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
632348001775	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
632348001776	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
632348001777	Zn2+ binding site [ion binding]; other site
632348001778	Mg2+ binding site [ion binding]; other site
632348001779	ribonuclease R; Region: RNase_R; TIGR02063
632348001780	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
632348001781	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
632348001782	RNB domain; Region: RNB; pfam00773
632348001783	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
632348001784	RNA binding site [nucleotide binding]; other site
632348001785	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
632348001786	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
632348001787	Walker A motif; other site
632348001788	ATP binding site [chemical binding]; other site
632348001789	Walker B motif; other site
632348001790	arginine finger; other site
632348001791	Uncharacterized conserved protein [Function unknown]; Region: COG2006
632348001792	Domain of unknown function (DUF362); Region: DUF362; pfam04015
632348001793	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
632348001794	30S subunit binding site; other site
632348001795	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
632348001796	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
632348001797	ATP binding site [chemical binding]; other site
632348001798	putative Mg++ binding site [ion binding]; other site
632348001799	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
632348001800	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
632348001801	nucleotide binding region [chemical binding]; other site
632348001802	ATP-binding site [chemical binding]; other site
632348001803	peptide chain release factor 2; Validated; Region: prfB; PRK00578
632348001804	This domain is found in peptide chain release factors; Region: PCRF; smart00937
632348001805	RF-1 domain; Region: RF-1; pfam00472
632348001806	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
632348001807	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
632348001808	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
632348001809	substrate binding site [chemical binding]; other site
632348001810	ligand binding site [chemical binding]; other site
632348001811	3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439
632348001812	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
632348001813	substrate binding site [chemical binding]; other site
632348001814	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
632348001815	tartrate dehydrogenase; Region: TTC; TIGR02089
632348001816	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
632348001817	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
632348001818	active site
632348001819	catalytic tetrad [active]
632348001820	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
632348001821	Ribosomal protein S6; Region: Ribosomal_S6; pfam01250
632348001822	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
632348001823	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
632348001824	dimer interface [polypeptide binding]; other site
632348001825	ssDNA binding site [nucleotide binding]; other site
632348001826	tetramer (dimer of dimers) interface [polypeptide binding]; other site
632348001827	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
632348001828	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
632348001829	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
632348001830	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632348001831	dimer interface [polypeptide binding]; other site
632348001832	conserved gate region; other site
632348001833	ABC-ATPase subunit interface; other site
632348001834	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
632348001835	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632348001836	dimer interface [polypeptide binding]; other site
632348001837	conserved gate region; other site
632348001838	putative PBP binding loops; other site
632348001839	ABC-ATPase subunit interface; other site
632348001840	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
632348001841	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
632348001842	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
632348001843	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
632348001844	Walker A motif; other site
632348001845	ATP binding site [chemical binding]; other site
632348001846	Walker B motif; other site
632348001847	arginine finger; other site
632348001848	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
632348001849	Integrase core domain; Region: rve; pfam00665
632348001850	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
632348001851	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565
632348001852	phosphate binding site [ion binding]; other site
632348001853	4Fe-4S binding domain; Region: Fer4_6; pfam12837
632348001854	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
632348001855	4Fe-4S binding domain; Region: Fer4; pfam00037
632348001856	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK06263
632348001857	L-aspartate oxidase; Provisional; Region: PRK06175
632348001858	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
632348001859	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
632348001860	Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231
632348001861	catalytic Zn binding site [ion binding]; other site
632348001862	structural Zn binding site [ion binding]; other site
632348001863	tetramer interface [polypeptide binding]; other site
632348001864	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
632348001865	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
632348001866	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
632348001867	Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318
632348001868	metal binding site [ion binding]; metal-binding site
632348001869	active site
632348001870	S-layer homology domain; Region: SLH; pfam00395
632348001871	S-layer homology domain; Region: SLH; pfam00395
632348001872	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
632348001873	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
632348001874	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
632348001875	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
632348001876	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632348001877	putative PBP binding loops; other site
632348001878	dimer interface [polypeptide binding]; other site
632348001879	ABC-ATPase subunit interface; other site
632348001880	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
632348001881	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632348001882	dimer interface [polypeptide binding]; other site
632348001883	conserved gate region; other site
632348001884	putative PBP binding loops; other site
632348001885	ABC-ATPase subunit interface; other site
632348001886	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
632348001887	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
632348001888	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
632348001889	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
632348001890	active site
632348001891	oxyanion hole [active]
632348001892	Transcriptional regulators [Transcription]; Region: PurR; COG1609
632348001893	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
632348001894	DNA binding site [nucleotide binding]
632348001895	domain linker motif; other site
632348001896	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
632348001897	dimerization interface [polypeptide binding]; other site
632348001898	ligand binding site [chemical binding]; other site
632348001899	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
632348001900	intersubunit interface [polypeptide binding]; other site
632348001901	active site
632348001902	zinc binding site [ion binding]; other site
632348001903	Na+ binding site [ion binding]; other site
632348001904	NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236
632348001905	galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309
632348001906	putative NAD(P) binding site [chemical binding]; other site
632348001907	catalytic Zn binding site [ion binding]; other site
632348001908	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
632348001909	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH1; cd08185
632348001910	putative active site [active]
632348001911	metal binding site [ion binding]; metal-binding site
632348001912	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
632348001913	uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804
632348001914	N- and C-terminal domain interface [polypeptide binding]; other site
632348001915	putative active site [active]
632348001916	MgATP binding site [chemical binding]; other site
632348001917	catalytic site [active]
632348001918	metal binding site [ion binding]; metal-binding site
632348001919	putative xylulose binding site [chemical binding]; other site
632348001920	putative homodimer interface [polypeptide binding]; other site
632348001921	Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211
632348001922	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
632348001923	Helix-turn-helix domain; Region: HTH_38; pfam13936
632348001924	DNA-binding interface [nucleotide binding]; DNA binding site
632348001925	Integrase core domain; Region: rve; pfam00665
632348001926	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
632348001927	magnesium-transporting ATPase; Provisional; Region: PRK15122
632348001928	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
632348001929	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
632348001930	Soluble P-type ATPase [General function prediction only]; Region: COG4087
632348001931	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
632348001932	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
632348001933	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
632348001934	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632348001935	dimer interface [polypeptide binding]; other site
632348001936	conserved gate region; other site
632348001937	ABC-ATPase subunit interface; other site
632348001938	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
632348001939	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632348001940	dimer interface [polypeptide binding]; other site
632348001941	conserved gate region; other site
632348001942	putative PBP binding loops; other site
632348001943	ABC-ATPase subunit interface; other site
632348001944	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
632348001945	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
632348001946	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
632348001947	YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593
632348001948	active site
632348001949	homotrimer interface [polypeptide binding]; other site
632348001950	catalytic site [active]
632348001951	homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site
632348001952	Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229
632348001953	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
632348001954	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
632348001955	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
632348001956	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
632348001957	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
632348001958	alpha-galactosidase; Provisional; Region: PRK15076
632348001959	Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297
632348001960	NAD binding site [chemical binding]; other site
632348001961	sugar binding site [chemical binding]; other site
632348001962	divalent metal binding site [ion binding]; other site
632348001963	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
632348001964	dimer interface [polypeptide binding]; other site
632348001965	putative alpha-glucosidase; Provisional; Region: PRK10658
632348001966	XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591
632348001967	putative active site [active]
632348001968	putative catalytic site [active]
632348001969	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
632348001970	Carboxylesterase family; Region: COesterase; pfam00135
632348001971	substrate binding pocket [chemical binding]; other site
632348001972	catalytic triad [active]
632348001973	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
632348001974	Beta-lactamase; Region: Beta-lactamase; pfam00144
632348001975	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
632348001976	Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285
632348001977	inhibitor binding site; inhibition site
632348001978	catalytic Zn binding site [ion binding]; other site
632348001979	structural Zn binding site [ion binding]; other site
632348001980	NADP binding site [chemical binding]; other site
632348001981	tetramer interface [polypeptide binding]; other site
632348001982	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
632348001983	substrate binding site [chemical binding]; other site
632348001984	Mn binding site [ion binding]; other site
632348001985	Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812
632348001986	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
632348001987	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
632348001988	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
632348001989	23S rRNA interface [nucleotide binding]; other site
632348001990	L3 interface [polypeptide binding]; other site
632348001991	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
632348001992	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
632348001993	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
632348001994	Nitrogen regulatory protein P-II; Region: P-II; smart00938
632348001995	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
632348001996	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
632348001997	DNA repair protein RadA; Provisional; Region: PRK11823
632348001998	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
632348001999	Walker A motif/ATP binding site; other site
632348002000	ATP binding site [chemical binding]; other site
632348002001	Walker B motif; other site
632348002002	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
632348002003	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
632348002004	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
632348002005	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
632348002006	polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609
632348002007	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
632348002008	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
632348002009	Uncharacterized conserved protein [Function unknown]; Region: COG1284
632348002010	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
632348002011	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
632348002012	transketolase; Reviewed; Region: PRK05899
632348002013	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
632348002014	TPP-binding site [chemical binding]; other site
632348002015	dimer interface [polypeptide binding]; other site
632348002016	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
632348002017	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
632348002018	PYR/PP interface [polypeptide binding]; other site
632348002019	dimer interface [polypeptide binding]; other site
632348002020	TPP binding site [chemical binding]; other site
632348002021	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
632348002022	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
632348002023	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
632348002024	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632348002025	putative alpha-glucosidase; Provisional; Region: PRK10658
632348002026	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
632348002027	YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593
632348002028	active site
632348002029	homotrimer interface [polypeptide binding]; other site
632348002030	catalytic site [active]
632348002031	homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site
632348002032	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
632348002033	dimerization interface [polypeptide binding]; other site
632348002034	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
632348002035	Histidine kinase; Region: His_kinase; pfam06580
632348002036	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
632348002037	ATP binding site [chemical binding]; other site
632348002038	Mg2+ binding site [ion binding]; other site
632348002039	G-X-G motif; other site
632348002040	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
632348002041	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632348002042	active site
632348002043	phosphorylation site [posttranslational modification]
632348002044	intermolecular recognition site; other site
632348002045	dimerization interface [polypeptide binding]; other site
632348002046	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632348002047	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632348002048	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
632348002049	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632348002050	dimer interface [polypeptide binding]; other site
632348002051	conserved gate region; other site
632348002052	ABC-ATPase subunit interface; other site
632348002053	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
632348002054	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632348002055	dimer interface [polypeptide binding]; other site
632348002056	conserved gate region; other site
632348002057	ABC-ATPase subunit interface; other site
632348002058	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
632348002059	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
632348002060	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
632348002061	MgtC family; Region: MgtC; pfam02308
632348002062	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
632348002063	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
632348002064	homodimer interface [polypeptide binding]; other site
632348002065	pyridoxal 5'-phosphate binding site [chemical binding]; other site
632348002066	catalytic residue [active]
632348002067	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
632348002068	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
632348002069	dimerization interface [polypeptide binding]; other site
632348002070	active site
632348002071	metal binding site [ion binding]; metal-binding site
632348002072	Protein of unknown function (DUF1646); Region: DUF1646; pfam07854
632348002073	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
632348002074	DNA replication protein DnaC; Validated; Region: PRK06835
632348002075	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
632348002076	Walker A motif; other site
632348002077	ATP binding site [chemical binding]; other site
632348002078	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
632348002079	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
632348002080	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
632348002081	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
632348002082	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
632348002083	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
632348002084	YacP-like NYN domain; Region: NYN_YacP; pfam05991
632348002085	RNA polymerase factor sigma-70; Validated; Region: PRK08295
632348002086	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
632348002087	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
632348002088	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
632348002089	This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800
632348002090	active site
632348002091	substrate binding site [chemical binding]; other site
632348002092	metal binding site [ion binding]; metal-binding site
632348002093	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
632348002094	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
632348002095	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
632348002096	glutamate racemase; Provisional; Region: PRK00865
632348002097	Domain of unknown function (DUF1934); Region: DUF1934; pfam09148
632348002098	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
632348002099	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
632348002100	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
632348002101	active site
632348002102	HIGH motif; other site
632348002103	KMSK motif region; other site
632348002104	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
632348002105	tRNA binding surface [nucleotide binding]; other site
632348002106	anticodon binding site; other site
632348002107	putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304
632348002108	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
632348002109	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
632348002110	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
632348002111	active site
632348002112	FMN binding site [chemical binding]; other site
632348002113	substrate binding site [chemical binding]; other site
632348002114	3Fe-4S cluster binding site [ion binding]; other site
632348002115	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
632348002116	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632348002117	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
632348002118	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
632348002119	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632348002120	dimer interface [polypeptide binding]; other site
632348002121	conserved gate region; other site
632348002122	ABC-ATPase subunit interface; other site
632348002123	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
632348002124	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632348002125	dimer interface [polypeptide binding]; other site
632348002126	ABC-ATPase subunit interface; other site
632348002127	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
632348002128	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
632348002129	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
632348002130	Int/Topo IB signature motif; other site
632348002131	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
632348002132	DNA-binding interface [nucleotide binding]; DNA binding site
632348002133	PrgI family protein; Region: PrgI; pfam12666
632348002134	AAA-like domain; Region: AAA_10; pfam12846
632348002135	Domain of unknown function DUF87; Region: DUF87; pfam01935
632348002136	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
632348002137	active site
632348002138	Predicted ATPase [General function prediction only]; Region: COG5293
632348002139	Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088
632348002140	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
632348002141	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
632348002142	IHF dimer interface [polypeptide binding]; other site
632348002143	IHF - DNA interface [nucleotide binding]; other site
632348002144	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
632348002145	PRTRC system protein D; Region: PRTRC_D; TIGR03739
632348002146	Mg binding site [ion binding]; other site
632348002147	nucleotide binding site [chemical binding]; other site
632348002148	putative protofilament interface [polypeptide binding]; other site
632348002149	Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534
632348002150	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
632348002151	Walker A motif; other site
632348002152	ATP binding site [chemical binding]; other site
632348002153	Walker B motif; other site
632348002154	Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]; Region: RpsA; COG0539
632348002155	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
632348002156	RNA binding site [nucleotide binding]; other site
632348002157	homodimer interface [polypeptide binding]; other site
632348002158	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
632348002159	RNA binding site [nucleotide binding]; other site
632348002160	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
632348002161	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
632348002162	Probable transposase; Region: OrfB_IS605; pfam01385
632348002163	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
632348002164	Predicted double-stranded RNA/RNA-DNA hybrid binding protein [General function prediction only]; Region: COG3341
632348002165	Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693
632348002166	Bacterial RNase HI containing a hybrid binding domain (HBD) at the N-terminus; Region: RNase_HI_bacteria_HBD; cd09277
632348002167	RNA/DNA hybrid binding site [nucleotide binding]; other site
632348002168	active site
632348002169	REJ domain; Region: REJ; pfam02010
632348002170	P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788
632348002171	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
632348002172	Walker A motif; other site
632348002173	ATP binding site [chemical binding]; other site
632348002174	Walker B motif; other site
632348002175	Methyltransferase domain; Region: Methyltransf_23; pfam13489
632348002176	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
632348002177	S-adenosylmethionine binding site [chemical binding]; other site
632348002178	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
632348002179	active site
632348002180	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
632348002181	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
632348002182	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
632348002183	dimer interface [polypeptide binding]; other site
632348002184	ssDNA binding site [nucleotide binding]; other site
632348002185	tetramer (dimer of dimers) interface [polypeptide binding]; other site
632348002186	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
632348002187	Zn2+ binding site [ion binding]; other site
632348002188	Mg2+ binding site [ion binding]; other site
632348002189	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868
632348002190	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
632348002191	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
632348002192	N-acetyl-D-glucosamine binding site [chemical binding]; other site
632348002193	catalytic residue [active]
632348002194	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
632348002195	Peptidase family M23; Region: Peptidase_M23; pfam01551
632348002196	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
632348002197	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
632348002198	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
632348002199	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
632348002200	active site
632348002201	DNA binding site [nucleotide binding]
632348002202	Int/Topo IB signature motif; other site
632348002203	Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782
632348002204	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
632348002205	Probable transposase; Region: OrfB_IS605; pfam01385
632348002206	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
632348002207	RecT family; Region: RecT; pfam03837
632348002208	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
632348002209	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
632348002210	MPN+ (JAMM) motif; other site
632348002211	Zinc-binding site [ion binding]; other site
632348002212	Uncharacterized protein conserved in bacteria (DUF2321); Region: DUF2321; pfam10083
632348002213	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
632348002214	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
632348002215	Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297
632348002216	NAD binding site [chemical binding]; other site
632348002217	sugar binding site [chemical binding]; other site
632348002218	divalent metal binding site [ion binding]; other site
632348002219	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
632348002220	dimer interface [polypeptide binding]; other site
632348002221	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
632348002222	putative active site [active]
632348002223	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
632348002224	Ferritin-like domain; Region: Ferritin; pfam00210
632348002225	ferroxidase diiron center [ion binding]; other site
632348002226	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
632348002227	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
632348002228	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
632348002229	oligomerization interface [polypeptide binding]; other site
632348002230	active site
632348002231	metal binding site [ion binding]; metal-binding site
632348002232	pantoate--beta-alanine ligase; Region: panC; TIGR00018
632348002233	Pantoate-beta-alanine ligase; Region: PanC; cd00560
632348002234	active site
632348002235	ATP-binding site [chemical binding]; other site
632348002236	pantoate-binding site; other site
632348002237	HXXH motif; other site
632348002238	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
632348002239	tetramerization interface [polypeptide binding]; other site
632348002240	active site
632348002241	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
632348002242	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
632348002243	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
632348002244	Coat F domain; Region: Coat_F; pfam07875
632348002245	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
632348002246	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
632348002247	Coenzyme A binding pocket [chemical binding]; other site
632348002248	Domain of unknown function (DUF4364); Region: DUF4364; pfam14277
632348002249	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
632348002250	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
632348002251	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
632348002252	DNA interaction; other site
632348002253	Metal-binding active site; metal-binding site
632348002254	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
632348002255	Radical SAM superfamily; Region: Radical_SAM; pfam04055
632348002256	FeS/SAM binding site; other site
632348002257	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
632348002258	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
632348002259	FeS/SAM binding site; other site
632348002260	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
632348002261	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
632348002262	Protein of unknown function (DUF2679); Region: DUF2679; pfam10882
632348002263	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
632348002264	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
632348002265	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
632348002266	Walker A/P-loop; other site
632348002267	ATP binding site [chemical binding]; other site
632348002268	Q-loop/lid; other site
632348002269	ABC transporter signature motif; other site
632348002270	Walker B; other site
632348002271	D-loop; other site
632348002272	H-loop/switch region; other site
632348002273	aspartate kinase; Reviewed; Region: PRK06635
632348002274	AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246
632348002275	putative catalytic residues [active]
632348002276	putative nucleotide binding site [chemical binding]; other site
632348002277	putative aspartate binding site [chemical binding]; other site
632348002278	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
632348002279	putative allosteric regulatory site; other site
632348002280	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
632348002281	putative allosteric regulatory residue; other site
632348002282	homoserine kinase; Provisional; Region: PRK01212
632348002283	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
632348002284	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
632348002285	homoserine dehydrogenase; Provisional; Region: PRK06349
632348002286	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
632348002287	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
632348002288	hypothetical protein; Provisional; Region: PRK04435
632348002289	C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888
632348002290	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
632348002291	Spore germination protein; Region: Spore_permease; cl17796
632348002292	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
632348002293	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
632348002294	Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551
632348002295	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
632348002296	active site
632348002297	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
632348002298	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
632348002299	Zn2+ binding site [ion binding]; other site
632348002300	Mg2+ binding site [ion binding]; other site
632348002301	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
632348002302	synthetase active site [active]
632348002303	NTP binding site [chemical binding]; other site
632348002304	metal binding site [ion binding]; metal-binding site
632348002305	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
632348002306	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
632348002307	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
632348002308	putative active site [active]
632348002309	dimerization interface [polypeptide binding]; other site
632348002310	putative tRNAtyr binding site [nucleotide binding]; other site
632348002311	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
632348002312	coproporphyrinogen III oxidase; Provisional; Region: PRK08207
632348002313	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
632348002314	FeS/SAM binding site; other site
632348002315	Radical SAM superfamily; Region: Radical_SAM; pfam04055
632348002316	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
632348002317	FeS/SAM binding site; other site
632348002318	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
632348002319	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
632348002320	active site
632348002321	homodimer interface [polypeptide binding]; other site
632348002322	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
632348002323	Interdomain contacts; other site
632348002324	Cytokine receptor motif; other site
632348002325	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
632348002326	Interdomain contacts; other site
632348002327	Cytokine receptor motif; other site
632348002328	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
632348002329	Interdomain contacts; other site
632348002330	Cytokine receptor motif; other site
632348002331	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
632348002332	Interdomain contacts; other site
632348002333	Cytokine receptor motif; other site
632348002334	S-layer homology domain; Region: SLH; pfam00395
632348002335	S-layer homology domain; Region: SLH; pfam00395
632348002336	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
632348002337	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
632348002338	substrate binding pocket [chemical binding]; other site
632348002339	membrane-bound complex binding site; other site
632348002340	hinge residues; other site
632348002341	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
632348002342	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632348002343	dimer interface [polypeptide binding]; other site
632348002344	conserved gate region; other site
632348002345	putative PBP binding loops; other site
632348002346	ABC-ATPase subunit interface; other site
632348002347	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
632348002348	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
632348002349	Walker A/P-loop; other site
632348002350	ATP binding site [chemical binding]; other site
632348002351	Q-loop/lid; other site
632348002352	ABC transporter signature motif; other site
632348002353	Walker B; other site
632348002354	D-loop; other site
632348002355	H-loop/switch region; other site
632348002356	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
632348002357	EamA-like transporter family; Region: EamA; pfam00892
632348002358	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
632348002359	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
632348002360	Beta-Casp domain; Region: Beta-Casp; smart01027
632348002361	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
632348002362	Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719
632348002363	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
632348002364	Transposase; Region: DDE_Tnp_ISL3; pfam01610
632348002365	Ferredoxin [Energy production and conversion]; Region: COG1146
632348002366	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
632348002367	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
632348002368	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
632348002369	arsenical-resistance protein; Region: acr3; TIGR00832
632348002370	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
632348002371	Low molecular weight phosphatase family; Region: LMWPc; cd00115
632348002372	active site
632348002373	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
632348002374	dimerization interface [polypeptide binding]; other site
632348002375	putative DNA binding site [nucleotide binding]; other site
632348002376	putative Zn2+ binding site [ion binding]; other site
632348002377	Transposase [DNA replication, recombination, and repair]; Region: COG5421
632348002378	Domain of unknown function DUF1828; Region: DUF1828; pfam08861
632348002379	Domain of unknown function DUF1829; Region: DUF1829; pfam08862
632348002380	Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782
632348002381	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
632348002382	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
632348002383	DNA primase (bacterial type) [DNA replication, recombination, and repair]; Region: DnaG; COG0358
632348002384	CHC2 zinc finger; Region: zf-CHC2; pfam01807
632348002385	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
632348002386	active site
632348002387	metal binding site [ion binding]; metal-binding site
632348002388	interdomain interaction site; other site
632348002389	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
632348002390	Walker A motif; other site
632348002391	ATP binding site [chemical binding]; other site
632348002392	Walker B motif; other site
632348002393	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
632348002394	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
632348002395	non-specific DNA binding site [nucleotide binding]; other site
632348002396	salt bridge; other site
632348002397	sequence-specific DNA binding site [nucleotide binding]; other site
632348002398	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
632348002399	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
632348002400	active site
632348002401	DNA binding site [nucleotide binding]
632348002402	Int/Topo IB signature motif; other site
632348002403	Abhydrolase family; Region: Abhydrolase_7; pfam12715
632348002404	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
632348002405	Anabaena sensory rhodopsin transducer; Region: ASRT; pfam07100
632348002406	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
632348002407	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
632348002408	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
632348002409	Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533
632348002410	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
632348002411	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
632348002412	FeS/SAM binding site; other site
632348002413	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
632348002414	probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915
632348002415	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
632348002416	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
632348002417	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
632348002418	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
632348002419	active site
632348002420	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
632348002421	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
632348002422	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
632348002423	Competence protein; Region: Competence; pfam03772
632348002424	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
632348002425	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
632348002426	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
632348002427	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
632348002428	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
632348002429	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
632348002430	A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292
632348002431	NAD binding site [chemical binding]; other site
632348002432	dimer interface [polypeptide binding]; other site
632348002433	substrate binding site [chemical binding]; other site
632348002434	tetramer (dimer of dimers) interface [polypeptide binding]; other site
632348002435	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
632348002436	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632348002437	dimer interface [polypeptide binding]; other site
632348002438	conserved gate region; other site
632348002439	putative PBP binding loops; other site
632348002440	ABC-ATPase subunit interface; other site
632348002441	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
632348002442	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
632348002443	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632348002444	dimer interface [polypeptide binding]; other site
632348002445	conserved gate region; other site
632348002446	putative PBP binding loops; other site
632348002447	ABC-ATPase subunit interface; other site
632348002448	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
632348002449	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
632348002450	Walker A/P-loop; other site
632348002451	ATP binding site [chemical binding]; other site
632348002452	Q-loop/lid; other site
632348002453	ABC transporter signature motif; other site
632348002454	Walker B; other site
632348002455	D-loop; other site
632348002456	H-loop/switch region; other site
632348002457	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
632348002458	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
632348002459	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
632348002460	Walker A/P-loop; other site
632348002461	ATP binding site [chemical binding]; other site
632348002462	Q-loop/lid; other site
632348002463	ABC transporter signature motif; other site
632348002464	Walker B; other site
632348002465	D-loop; other site
632348002466	H-loop/switch region; other site
632348002467	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
632348002468	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
632348002469	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
632348002470	peptide binding site [polypeptide binding]; other site
632348002471	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
632348002472	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
632348002473	metal binding site [ion binding]; metal-binding site
632348002474	dimer interface [polypeptide binding]; other site
632348002475	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
632348002476	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
632348002477	DNA-binding site [nucleotide binding]; DNA binding site
632348002478	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
632348002479	pyridoxal 5'-phosphate binding site [chemical binding]; other site
632348002480	homodimer interface [polypeptide binding]; other site
632348002481	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
632348002482	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
632348002483	active site
632348002484	multimer interface [polypeptide binding]; other site
632348002485	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
632348002486	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
632348002487	predicted active site [active]
632348002488	catalytic triad [active]
632348002489	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
632348002490	Uncharacterized conserved protein [Function unknown]; Region: COG0062
632348002491	putative carbohydrate kinase; Provisional; Region: PRK10565
632348002492	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
632348002493	putative substrate binding site [chemical binding]; other site
632348002494	putative ATP binding site [chemical binding]; other site
632348002495	alanine racemase; Reviewed; Region: alr; PRK00053
632348002496	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
632348002497	active site
632348002498	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
632348002499	dimer interface [polypeptide binding]; other site
632348002500	substrate binding site [chemical binding]; other site
632348002501	catalytic residues [active]
632348002502	PemK-like protein; Region: PemK; pfam02452
632348002503	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
632348002504	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
632348002505	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
632348002506	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
632348002507	catalytic residues [active]
632348002508	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
632348002509	lipoyl-biotinyl attachment site [posttranslational modification]; other site
632348002510	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
632348002511	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
632348002512	intersubunit interface [polypeptide binding]; other site
632348002513	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
632348002514	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
632348002515	ABC-ATPase subunit  interface; other site
632348002516	dimer interface [polypeptide binding]; other site
632348002517	putative PBP binding regions; other site
632348002518	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
632348002519	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
632348002520	Walker A/P-loop; other site
632348002521	ATP binding site [chemical binding]; other site
632348002522	Q-loop/lid; other site
632348002523	ABC transporter signature motif; other site
632348002524	Walker B; other site
632348002525	D-loop; other site
632348002526	H-loop/switch region; other site
632348002527	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
632348002528	Bacterial SH3 domain; Region: SH3_3; pfam08239
632348002529	Bacterial SH3 domain homologues; Region: SH3b; smart00287
632348002530	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
632348002531	NlpC/P60 family; Region: NLPC_P60; pfam00877
632348002532	Domain of unknown function (DUF4380); Region: DUF4380; pfam14315
632348002533	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
632348002534	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
632348002535	active site
632348002536	motif I; other site
632348002537	motif II; other site
632348002538	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
632348002539	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
632348002540	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
632348002541	shikimate binding site; other site
632348002542	NAD(P) binding site [chemical binding]; other site
632348002543	Response regulator receiver domain; Region: Response_reg; pfam00072
632348002544	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632348002545	active site
632348002546	phosphorylation site [posttranslational modification]
632348002547	intermolecular recognition site; other site
632348002548	dimerization interface [polypeptide binding]; other site
632348002549	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
632348002550	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
632348002551	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
632348002552	Walker A motif; other site
632348002553	ATP binding site [chemical binding]; other site
632348002554	Walker B motif; other site
632348002555	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
632348002556	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
632348002557	Walker A motif; other site
632348002558	ATP binding site [chemical binding]; other site
632348002559	Walker B motif; other site
632348002560	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
632348002561	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
632348002562	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
632348002563	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
632348002564	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
632348002565	Late competence development protein ComFB; Region: ComFB; pfam10719
632348002566	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
632348002567	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
632348002568	NHL repeat; Region: NHL; pfam01436
632348002569	NHL repeat; Region: NHL; pfam01436
632348002570	NHL repeat; Region: NHL; pfam01436
632348002571	NHL repeat; Region: NHL; pfam01436
632348002572	endoglucanase; Region: PLN02420
632348002573	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759
632348002574	Cellulose binding domain; Region: CBM_3; smart01067
632348002575	Cellulose binding domain; Region: CBM_3; pfam00942
632348002576	Cellulose binding domain; Region: CBM_3; pfam00942
632348002577	Glycosyl hydrolase family 48; Region: Glyco_hydro_48; pfam02011
632348002578	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
632348002579	Cellulose binding domain; Region: CBM_3; pfam00942
632348002580	Cellulose binding domain; Region: CBM_3; pfam00942
632348002581	Glycoside hydrolase family 44; Region: Glyco_hydro_44; pfam12891
632348002582	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331
632348002583	Cellulose binding domain; Region: CBM_3; pfam00942
632348002584	Cellulose binding domain; Region: CBM_3; pfam00942
632348002585	Glycosyl hydrolase family 48; Region: Glyco_hydro_48; pfam02011
632348002586	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
632348002587	Cellulose binding domain; Region: CBM_3; pfam00942
632348002588	Cellulose binding domain; Region: CBM_3; pfam00942
632348002589	Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730
632348002590	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
632348002591	potential frameshift: common BLAST hit: gi|302872300|ref|YP_003840936.1| Cellulase., Mannan endo-1,4-beta-mannosidase
632348002592	endoglucanase; Region: PLN02420
632348002593	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759
632348002594	Cellulose binding domain; Region: CBM_3; smart01067
632348002595	Cellulose binding domain; Region: CBM_3; pfam00942
632348002596	Cellulose binding domain; Region: CBM_3; pfam00942
632348002597	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
632348002598	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
632348002599	Predicted integral membrane protein [Function unknown]; Region: COG5542
632348002600	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
632348002601	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
632348002602	Cellulose binding domain; Region: CBM_3; pfam00942
632348002603	Cellulose binding domain; Region: CBM_3; pfam00942
632348002604	Glycosyl hydrolase family 48; Region: Glyco_hydro_48; pfam02011
632348002605	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
632348002606	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632348002607	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
632348002608	Pectate lyase; Region: Pectate_lyase; pfam03211
632348002609	Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318
632348002610	metal binding site [ion binding]; metal-binding site
632348002611	active site
632348002612	Cellulose binding domain; Region: CBM_3; pfam00942
632348002613	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
632348002614	Integrase core domain; Region: rve; pfam00665
632348002615	Double zinc ribbon; Region: DZR; pfam12773
632348002616	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
632348002617	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
632348002618	cyclase homology domain; Region: CHD; cd07302
632348002619	nucleotidyl binding site; other site
632348002620	metal binding site [ion binding]; metal-binding site
632348002621	dimer interface [polypeptide binding]; other site
632348002622	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
632348002623	Predicted ATPase [General function prediction only]; Region: COG3899
632348002624	Walker A motif; other site
632348002625	ATP binding site [chemical binding]; other site
632348002626	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
632348002627	binding surface
632348002628	TPR motif; other site
632348002629	Tetratricopeptide repeat; Region: TPR_12; pfam13424
632348002630	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
632348002631	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
632348002632	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
632348002633	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
632348002634	metal binding site [ion binding]; metal-binding site
632348002635	active site
632348002636	I-site; other site
632348002637	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
632348002638	GAF domain; Region: GAF; cl17456
632348002639	S-layer homology domain; Region: SLH; pfam00395
632348002640	S-layer homology domain; Region: SLH; pfam00395
632348002641	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
632348002642	Fe-S cluster binding site [ion binding]; other site
632348002643	active site
632348002644	acetylornithine aminotransferase; Provisional; Region: PRK02627
632348002645	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
632348002646	inhibitor-cofactor binding pocket; inhibition site
632348002647	pyridoxal 5'-phosphate binding site [chemical binding]; other site
632348002648	catalytic residue [active]
632348002649	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
632348002650	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
632348002651	Bacitracin resistance protein BacA; Region: BacA; pfam02673
632348002652	UGMP family protein; Validated; Region: PRK09604
632348002653	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
632348002654	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
632348002655	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
632348002656	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
632348002657	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
632348002658	Zn2+ binding site [ion binding]; other site
632348002659	Mg2+ binding site [ion binding]; other site
632348002660	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
632348002661	elongation factor G; Reviewed; Region: PRK12740
632348002662	G1 box; other site
632348002663	putative GEF interaction site [polypeptide binding]; other site
632348002664	GTP/Mg2+ binding site [chemical binding]; other site
632348002665	Switch I region; other site
632348002666	G2 box; other site
632348002667	G3 box; other site
632348002668	Switch II region; other site
632348002669	G4 box; other site
632348002670	G5 box; other site
632348002671	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
632348002672	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
632348002673	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
632348002674	Probable zinc-binding domain; Region: zf-trcl; pfam13451
632348002675	CxxC-x17-CxxC domain; Region: cxxc_cxxc_Mbark; TIGR04272
632348002676	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
632348002677	Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944
632348002678	NodB motif; other site
632348002679	active site
632348002680	catalytic site [active]
632348002681	Zn binding site [ion binding]; other site
632348002682	Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848
632348002683	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
632348002684	UvrB/uvrC motif; Region: UVR; pfam02151
632348002685	ATP:guanido phosphotransferase; Provisional; Region: PRK01059
632348002686	Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930
632348002687	ADP binding site [chemical binding]; other site
632348002688	phosphagen binding site; other site
632348002689	substrate specificity loop; other site
632348002690	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
632348002691	Clp amino terminal domain; Region: Clp_N; pfam02861
632348002692	Clp amino terminal domain; Region: Clp_N; pfam02861
632348002693	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
632348002694	Walker A motif; other site
632348002695	ATP binding site [chemical binding]; other site
632348002696	Walker B motif; other site
632348002697	arginine finger; other site
632348002698	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
632348002699	Walker A motif; other site
632348002700	ATP binding site [chemical binding]; other site
632348002701	Walker B motif; other site
632348002702	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
632348002703	6-phosphofructokinase; Provisional; Region: PRK14072
632348002704	active site
632348002705	ADP/pyrophosphate binding site [chemical binding]; other site
632348002706	dimerization interface [polypeptide binding]; other site
632348002707	allosteric effector site; other site
632348002708	fructose-1,6-bisphosphate binding site; other site
632348002709	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
632348002710	Domain of unknown function (DUF814); Region: DUF814; pfam05670
632348002711	O-Antigen ligase; Region: Wzy_C; cl04850
632348002712	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
632348002713	Domain of unknown function (DUF4330); Region: DUF4330; pfam14221
632348002714	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
632348002715	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
632348002716	putative homodimer interface [polypeptide binding]; other site
632348002717	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
632348002718	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
632348002719	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
632348002720	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
632348002721	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
632348002722	rRNA interaction site [nucleotide binding]; other site
632348002723	S8 interaction site; other site
632348002724	putative laminin-1 binding site; other site
632348002725	elongation factor Ts; Reviewed; Region: tsf; PRK12332
632348002726	UBA/TS-N domain; Region: UBA; pfam00627
632348002727	Elongation factor TS; Region: EF_TS; pfam00889
632348002728	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
632348002729	putative nucleotide binding site [chemical binding]; other site
632348002730	uridine monophosphate binding site [chemical binding]; other site
632348002731	homohexameric interface [polypeptide binding]; other site
632348002732	ribosome recycling factor; Reviewed; Region: frr; PRK00083
632348002733	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
632348002734	hinge region; other site
632348002735	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
632348002736	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
632348002737	catalytic residue [active]
632348002738	putative FPP diphosphate  binding site; other site
632348002739	putative FPP binding hydrophobic cleft; other site
632348002740	dimer interface [polypeptide binding]; other site
632348002741	putative IPP diphosphate binding site; other site
632348002742	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
632348002743	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
632348002744	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
632348002745	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
632348002746	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
632348002747	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
632348002748	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
632348002749	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
632348002750	active site
632348002751	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
632348002752	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
632348002753	putative substrate binding region [chemical binding]; other site
632348002754	GcpE protein; Region: GcpE; pfam04551
632348002755	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
632348002756	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
632348002757	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
632348002758	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
632348002759	Ligand binding site; other site
632348002760	Putative Catalytic site; other site
632348002761	DXD motif; other site
632348002762	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
632348002763	DNA polymerase III PolC; Validated; Region: polC; PRK00448
632348002764	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
632348002765	generic binding surface II; other site
632348002766	generic binding surface I; other site
632348002767	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
632348002768	active site
632348002769	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
632348002770	active site
632348002771	catalytic site [active]
632348002772	substrate binding site [chemical binding]; other site
632348002773	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
632348002774	Thiamine pyrophosphokinase; Region: TPK; cd07995
632348002775	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
632348002776	active site
632348002777	dimerization interface [polypeptide binding]; other site
632348002778	thiamine binding site [chemical binding]; other site
632348002779	Predicted membrane protein [Function unknown]; Region: COG2261
632348002780	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
632348002781	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
632348002782	Walker A/P-loop; other site
632348002783	ATP binding site [chemical binding]; other site
632348002784	Q-loop/lid; other site
632348002785	ABC transporter signature motif; other site
632348002786	Walker B; other site
632348002787	D-loop; other site
632348002788	H-loop/switch region; other site
632348002789	TOBE domain; Region: TOBE; pfam03459
632348002790	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
632348002791	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
632348002792	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
632348002793	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
632348002794	Walker A/P-loop; other site
632348002795	ATP binding site [chemical binding]; other site
632348002796	Q-loop/lid; other site
632348002797	ABC transporter signature motif; other site
632348002798	Walker B; other site
632348002799	D-loop; other site
632348002800	H-loop/switch region; other site
632348002801	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
632348002802	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
632348002803	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
632348002804	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
632348002805	Peptidase family M23; Region: Peptidase_M23; pfam01551
632348002806	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
632348002807	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
632348002808	protein binding site [polypeptide binding]; other site
632348002809	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
632348002810	Catalytic dyad [active]
632348002811	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
632348002812	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
632348002813	Peptidase family M23; Region: Peptidase_M23; pfam01551
632348002814	diacylglycerol glucosyltransferase; Provisional; Region: PRK13609
632348002815	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
632348002816	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
632348002817	germination protein YpeB; Region: spore_YpeB; TIGR02889
632348002818	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
632348002819	germination protease; Provisional; Region: PRK12362
632348002820	Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454
632348002821	stage II sporulation protein P; Region: spore_II_P; TIGR02867
632348002822	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
632348002823	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
632348002824	active site
632348002825	DNA binding site [nucleotide binding]
632348002826	Int/Topo IB signature motif; other site
632348002827	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
632348002828	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
632348002829	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
632348002830	catalytic triad [active]
632348002831	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
632348002832	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
632348002833	ligand binding site [chemical binding]; other site
632348002834	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
632348002835	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
632348002836	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
632348002837	Walker A/P-loop; other site
632348002838	ATP binding site [chemical binding]; other site
632348002839	Q-loop/lid; other site
632348002840	ABC transporter signature motif; other site
632348002841	Walker B; other site
632348002842	D-loop; other site
632348002843	H-loop/switch region; other site
632348002844	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
632348002845	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
632348002846	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
632348002847	TM-ABC transporter signature motif; other site
632348002848	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
632348002849	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
632348002850	TM-ABC transporter signature motif; other site
632348002851	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
632348002852	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
632348002853	DNA-binding site [nucleotide binding]; DNA binding site
632348002854	UTRA domain; Region: UTRA; pfam07702
632348002855	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
632348002856	active site
632348002857	catalytic motif [active]
632348002858	Zn binding site [ion binding]; other site
632348002859	XapX domain; Region: XapX; TIGR03510
632348002860	pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644
632348002861	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
632348002862	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
632348002863	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
632348002864	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
632348002865	intersubunit interface [polypeptide binding]; other site
632348002866	active site
632348002867	catalytic residue [active]
632348002868	phosphopentomutase; Provisional; Region: PRK05362
632348002869	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
632348002870	purine nucleoside phosphorylase; Provisional; Region: PRK08202
632348002871	Response regulator receiver domain; Region: Response_reg; pfam00072
632348002872	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632348002873	active site
632348002874	phosphorylation site [posttranslational modification]
632348002875	intermolecular recognition site; other site
632348002876	dimerization interface [polypeptide binding]; other site
632348002877	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
632348002878	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
632348002879	putative binding surface; other site
632348002880	active site
632348002881	P2 response regulator binding domain; Region: P2; pfam07194
632348002882	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
632348002883	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
632348002884	ATP binding site [chemical binding]; other site
632348002885	Mg2+ binding site [ion binding]; other site
632348002886	G-X-G motif; other site
632348002887	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
632348002888	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
632348002889	CHASE3 domain; Region: CHASE3; cl05000
632348002890	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
632348002891	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
632348002892	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
632348002893	dimerization interface [polypeptide binding]; other site
632348002894	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
632348002895	dimer interface [polypeptide binding]; other site
632348002896	putative CheW interface [polypeptide binding]; other site
632348002897	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155
632348002898	YtxC-like family; Region: YtxC; pfam08812
632348002899	Trp repressor protein; Region: Trp_repressor; cl17266
632348002900	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
632348002901	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
632348002902	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
632348002903	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
632348002904	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
632348002905	protein binding site [polypeptide binding]; other site
632348002906	4Fe-4S binding domain; Region: Fer4; pfam00037
632348002907	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
632348002908	putative homodimer interface [polypeptide binding]; other site
632348002909	putative homotetramer interface [polypeptide binding]; other site
632348002910	putative allosteric switch controlling residues; other site
632348002911	putative metal binding site [ion binding]; other site
632348002912	putative homodimer-homodimer interface [polypeptide binding]; other site
632348002913	B12 binding domain; Region: B12-binding; pfam02310
632348002914	B12 binding site [chemical binding]; other site
632348002915	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
632348002916	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
632348002917	FeS/SAM binding site; other site
632348002918	Protein of unknown function (DUF4080); Region: DUF4080; pfam13311
632348002919	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845
632348002920	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
632348002921	M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659
632348002922	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
632348002923	oligomer interface [polypeptide binding]; other site
632348002924	putative active site [active]
632348002925	metal binding site [ion binding]; metal-binding site
632348002926	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
632348002927	This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800
632348002928	active site
632348002929	substrate binding site [chemical binding]; other site
632348002930	metal binding site [ion binding]; metal-binding site
632348002931	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
632348002932	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632348002933	active site
632348002934	phosphorylation site [posttranslational modification]
632348002935	intermolecular recognition site; other site
632348002936	dimerization interface [polypeptide binding]; other site
632348002937	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
632348002938	DNA binding site [nucleotide binding]
632348002939	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
632348002940	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
632348002941	dimerization interface [polypeptide binding]; other site
632348002942	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
632348002943	dimer interface [polypeptide binding]; other site
632348002944	phosphorylation site [posttranslational modification]
632348002945	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
632348002946	ATP binding site [chemical binding]; other site
632348002947	Mg2+ binding site [ion binding]; other site
632348002948	G-X-G motif; other site
632348002949	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
632348002950	Zn2+ binding site [ion binding]; other site
632348002951	Mg2+ binding site [ion binding]; other site
632348002952	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
632348002953	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
632348002954	Zn2+ binding site [ion binding]; other site
632348002955	Mg2+ binding site [ion binding]; other site
632348002956	Manganese catalase-like protein, ferritin-like diiron-binding domain; Region: Mn_catalase_like; cd07908
632348002957	Ferritin-like domain; Region: Ferritin; pfam00210
632348002958	dinuclear metal binding motif [ion binding]; other site
632348002959	Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202
632348002960	iron binding site [ion binding]; other site
632348002961	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
632348002962	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
632348002963	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
632348002964	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
632348002965	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
632348002966	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
632348002967	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
632348002968	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
632348002969	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
632348002970	putative translocon binding site; other site
632348002971	protein-rRNA interface [nucleotide binding]; other site
632348002972	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
632348002973	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
632348002974	G-X-X-G motif; other site
632348002975	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
632348002976	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
632348002977	23S rRNA interface [nucleotide binding]; other site
632348002978	5S rRNA interface [nucleotide binding]; other site
632348002979	putative antibiotic binding site [chemical binding]; other site
632348002980	L25 interface [polypeptide binding]; other site
632348002981	L27 interface [polypeptide binding]; other site
632348002982	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
632348002983	23S rRNA interface [nucleotide binding]; other site
632348002984	putative translocon interaction site; other site
632348002985	signal recognition particle (SRP54) interaction site; other site
632348002986	L23 interface [polypeptide binding]; other site
632348002987	trigger factor interaction site; other site
632348002988	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
632348002989	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
632348002990	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
632348002991	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
632348002992	RNA binding site [nucleotide binding]; other site
632348002993	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
632348002994	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
632348002995	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
632348002996	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
632348002997	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
632348002998	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
632348002999	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
632348003000	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
632348003001	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
632348003002	23S rRNA interface [nucleotide binding]; other site
632348003003	5S rRNA interface [nucleotide binding]; other site
632348003004	L27 interface [polypeptide binding]; other site
632348003005	L5 interface [polypeptide binding]; other site
632348003006	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
632348003007	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
632348003008	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
632348003009	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
632348003010	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
632348003011	SecY translocase; Region: SecY; pfam00344
632348003012	adenylate kinase; Reviewed; Region: adk; PRK00279
632348003013	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
632348003014	AMP-binding site [chemical binding]; other site
632348003015	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
632348003016	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
632348003017	active site
632348003018	KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088
632348003019	RNA binding site [nucleotide binding]; other site
632348003020	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
632348003021	rRNA binding site [nucleotide binding]; other site
632348003022	predicted 30S ribosome binding site; other site
632348003023	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
632348003024	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
632348003025	30S ribosomal protein S13; Region: bact_S13; TIGR03631
632348003026	30S ribosomal protein S11; Validated; Region: PRK05309
632348003027	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
632348003028	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
632348003029	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
632348003030	RNA binding surface [nucleotide binding]; other site
632348003031	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
632348003032	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
632348003033	alphaNTD homodimer interface [polypeptide binding]; other site
632348003034	alphaNTD - beta interaction site [polypeptide binding]; other site
632348003035	alphaNTD - beta' interaction site [polypeptide binding]; other site
632348003036	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
632348003037	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
632348003038	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
632348003039	Transcriptional regulator; Region: Rrf2; cl17282
632348003040	Rrf2 family protein; Region: rrf2_super; TIGR00738
632348003041	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
632348003042	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
632348003043	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
632348003044	catalytic residue [active]
632348003045	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
632348003046	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
632348003047	trimerization site [polypeptide binding]; other site
632348003048	active site
632348003049	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
632348003050	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
632348003051	Ligand Binding Site [chemical binding]; other site
632348003052	histidinol-phosphatase; Provisional; Region: PRK05588
632348003053	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
632348003054	active site
632348003055	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
632348003056	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
632348003057	active site
632348003058	NTP binding site [chemical binding]; other site
632348003059	metal binding triad [ion binding]; metal-binding site
632348003060	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
632348003061	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
632348003062	pyruvate ferredoxin oxidoreductase subunit gamma/delta; Provisional; Region: PRK14028
632348003063	4Fe-4S binding domain; Region: Fer4_6; pfam12837
632348003064	4Fe-4S binding domain; Region: Fer4; pfam00037
632348003065	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
632348003066	pyruvate flavodoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK09622
632348003067	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
632348003068	dimer interface [polypeptide binding]; other site
632348003069	PYR/PP interface [polypeptide binding]; other site
632348003070	TPP binding site [chemical binding]; other site
632348003071	substrate binding site [chemical binding]; other site
632348003072	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
632348003073	pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865
632348003074	Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376
632348003075	TPP-binding site [chemical binding]; other site
632348003076	putative dimer interface [polypeptide binding]; other site
632348003077	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
632348003078	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
632348003079	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
632348003080	Walker A/P-loop; other site
632348003081	ATP binding site [chemical binding]; other site
632348003082	Q-loop/lid; other site
632348003083	ABC transporter signature motif; other site
632348003084	Walker B; other site
632348003085	D-loop; other site
632348003086	H-loop/switch region; other site
632348003087	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
632348003088	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
632348003089	RNA polymerase sigma factor SigY; Reviewed; Region: PRK09638
632348003090	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
632348003091	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
632348003092	DNA binding residues [nucleotide binding]
632348003093	shikimate kinase; Reviewed; Region: aroK; PRK00131
632348003094	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
632348003095	ADP binding site [chemical binding]; other site
632348003096	magnesium binding site [ion binding]; other site
632348003097	putative shikimate binding site; other site
632348003098	AP endonuclease family 2; Region: AP2Ec; smart00518
632348003099	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
632348003100	Metal-binding active site; metal-binding site
632348003101	AP (apurinic/apyrimidinic) site pocket; other site
632348003102	Dehydroquinase class II; Region: DHquinase_II; pfam01220
632348003103	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
632348003104	trimer interface [polypeptide binding]; other site
632348003105	active site
632348003106	dimer interface [polypeptide binding]; other site
632348003107	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
632348003108	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
632348003109	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
632348003110	active site
632348003111	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
632348003112	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
632348003113	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
632348003114	Glutamine amidotransferase class-I; Region: GATase; pfam00117
632348003115	glutamine binding [chemical binding]; other site
632348003116	catalytic triad [active]
632348003117	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
632348003118	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
632348003119	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
632348003120	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
632348003121	active site
632348003122	ribulose/triose binding site [chemical binding]; other site
632348003123	phosphate binding site [ion binding]; other site
632348003124	substrate (anthranilate) binding pocket [chemical binding]; other site
632348003125	product (indole) binding pocket [chemical binding]; other site
632348003126	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
632348003127	active site
632348003128	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
632348003129	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
632348003130	pyridoxal 5'-phosphate binding site [chemical binding]; other site
632348003131	catalytic residue [active]
632348003132	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
632348003133	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
632348003134	substrate binding site [chemical binding]; other site
632348003135	active site
632348003136	catalytic residues [active]
632348003137	heterodimer interface [polypeptide binding]; other site
632348003138	cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633
632348003139	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
632348003140	Walker A/P-loop; other site
632348003141	ATP binding site [chemical binding]; other site
632348003142	Q-loop/lid; other site
632348003143	ABC transporter signature motif; other site
632348003144	Walker B; other site
632348003145	D-loop; other site
632348003146	H-loop/switch region; other site
632348003147	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637
632348003148	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
632348003149	Walker A/P-loop; other site
632348003150	ATP binding site [chemical binding]; other site
632348003151	Q-loop/lid; other site
632348003152	ABC transporter signature motif; other site
632348003153	Walker B; other site
632348003154	D-loop; other site
632348003155	H-loop/switch region; other site
632348003156	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
632348003157	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
632348003158	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
632348003159	dimerization interface 3.5A [polypeptide binding]; other site
632348003160	active site
632348003161	Uncharacterized conserved protein [Function unknown]; Region: COG1434
632348003162	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
632348003163	putative active site [active]
632348003164	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
632348003165	anti sigma factor interaction site; other site
632348003166	regulatory phosphorylation site [posttranslational modification]; other site
632348003167	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
632348003168	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
632348003169	ATP binding site [chemical binding]; other site
632348003170	Mg2+ binding site [ion binding]; other site
632348003171	G-X-G motif; other site
632348003172	sporulation sigma factor SigF; Validated; Region: PRK05572
632348003173	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
632348003174	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
632348003175	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
632348003176	DNA binding residues [nucleotide binding]
632348003177	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
632348003178	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
632348003179	active site
632348003180	flagellar operon protein TIGR03826; Region: YvyF
632348003181	Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316
632348003182	FlgN protein; Region: FlgN; pfam05130
632348003183	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739
632348003184	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
632348003185	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701
632348003186	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
632348003187	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
632348003188	Uncharacterized conserved protein [Function unknown]; Region: COG2445
632348003189	flagellar assembly protein FliW; Provisional; Region: PRK13285
632348003190	Global regulator protein family; Region: CsrA; pfam02599
632348003191	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
632348003192	AAA domain; Region: AAA_14; pfam13173
632348003193	P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923
632348003194	P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923
632348003195	P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923
632348003196	P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923
632348003197	P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923
632348003198	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
632348003199	CRISPR-associated helicase Cas3, subtype CYANO; Region: cas3_cyano; TIGR03158
632348003200	ATP binding site [chemical binding]; other site
632348003201	putative Mg++ binding site [ion binding]; other site
632348003202	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
632348003203	nucleotide binding region [chemical binding]; other site
632348003204	ATP-binding site [chemical binding]; other site
632348003205	flagellin; Provisional; Region: PRK12804
632348003206	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
632348003207	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
632348003208	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
632348003209	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
632348003210	active site
632348003211	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
632348003212	TPR motif; other site
632348003213	binding surface
632348003214	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
632348003215	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
632348003216	putative homodimer interface [polypeptide binding]; other site
632348003217	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
632348003218	active site
632348003219	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
632348003220	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
632348003221	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
632348003222	tungsten cofactor oxidoreducase radical SAM maturase; Region: W_rSAM_matur; TIGR04317
632348003223	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
632348003224	FeS/SAM binding site; other site
632348003225	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
632348003226	radical SAM/SPASM domain protein, ACGX system; Region: rSAM_ACGX; TIGR04340
632348003227	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
632348003228	FeS/SAM binding site; other site
632348003229	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
632348003230	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
632348003231	FeS/SAM binding site; other site
632348003232	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
632348003233	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
632348003234	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
632348003235	substrate binding site; other site
632348003236	CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622
632348003237	CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252
632348003238	NAD binding site [chemical binding]; other site
632348003239	homotetramer interface [polypeptide binding]; other site
632348003240	homodimer interface [polypeptide binding]; other site
632348003241	substrate binding site [chemical binding]; other site
632348003242	active site
632348003243	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
632348003244	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
632348003245	NAD(P) binding site [chemical binding]; other site
632348003246	active site
632348003247	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
632348003248	EcoRII C terminal; Region: EcoRII-C; pfam09019
632348003249	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
632348003250	DNA methylase; Region: N6_N4_Mtase; pfam01555
632348003251	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
632348003252	active site
632348003253	NTP binding site [chemical binding]; other site
632348003254	metal binding triad [ion binding]; metal-binding site
632348003255	FlaG protein; Region: FlaG; pfam03646
632348003256	flagellar capping protein; Validated; Region: fliD; PRK07737
632348003257	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
632348003258	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
632348003259	Flagellar protein FliS; Region: FliS; cl00654
632348003260	FlgN protein; Region: FlgN; pfam05130
632348003261	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
632348003262	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
632348003263	Major Facilitator Superfamily; Region: MFS_1; pfam07690
632348003264	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
632348003265	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
632348003266	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
632348003267	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
632348003268	gamma-glutamyl kinase; Provisional; Region: PRK05429
632348003269	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
632348003270	nucleotide binding site [chemical binding]; other site
632348003271	homotetrameric interface [polypeptide binding]; other site
632348003272	putative phosphate binding site [ion binding]; other site
632348003273	putative allosteric binding site; other site
632348003274	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
632348003275	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
632348003276	putative catalytic cysteine [active]
632348003277	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
632348003278	active site
632348003279	NTP binding site [chemical binding]; other site
632348003280	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
632348003281	metal binding triad [ion binding]; metal-binding site
632348003282	metal binding triad [ion binding]; metal-binding site
632348003283	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
632348003284	MutS domain III; Region: MutS_III; pfam05192
632348003285	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
632348003286	Walker A/P-loop; other site
632348003287	ATP binding site [chemical binding]; other site
632348003288	Q-loop/lid; other site
632348003289	ABC transporter signature motif; other site
632348003290	Walker B; other site
632348003291	D-loop; other site
632348003292	H-loop/switch region; other site
632348003293	Smr domain; Region: Smr; pfam01713
632348003294	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
632348003295	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
632348003296	Catalytic site [active]
632348003297	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
632348003298	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
632348003299	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
632348003300	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
632348003301	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
632348003302	active site
632348003303	aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648
632348003304	active site
632348003305	catalytic residues [active]
632348003306	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
632348003307	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
632348003308	Ligand Binding Site [chemical binding]; other site
632348003309	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
632348003310	AIR carboxylase; Region: AIRC; smart01001
632348003311	GTP-binding protein YchF; Reviewed; Region: PRK09601
632348003312	YchF GTPase; Region: YchF; cd01900
632348003313	G1 box; other site
632348003314	GTP/Mg2+ binding site [chemical binding]; other site
632348003315	Switch I region; other site
632348003316	G2 box; other site
632348003317	Switch II region; other site
632348003318	G3 box; other site
632348003319	G4 box; other site
632348003320	G5 box; other site
632348003321	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
632348003322	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
632348003323	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
632348003324	N-acetyl-D-glucosamine binding site [chemical binding]; other site
632348003325	catalytic residue [active]
632348003326	putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959
632348003327	Heme NO binding; Region: HNOB; pfam07700
632348003328	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
632348003329	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
632348003330	dimer interface [polypeptide binding]; other site
632348003331	putative CheW interface [polypeptide binding]; other site
632348003332	Predicted membrane protein [Function unknown]; Region: COG2510
632348003333	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
632348003334	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632348003335	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
632348003336	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632348003337	Uncharacterized conserved protein [Function unknown]; Region: COG2968
632348003338	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
632348003339	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
632348003340	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
632348003341	catalytic residues [active]
632348003342	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
632348003343	putative homodimer interface [polypeptide binding]; other site
632348003344	putative homotetramer interface [polypeptide binding]; other site
632348003345	putative allosteric switch controlling residues; other site
632348003346	putative metal binding site [ion binding]; other site
632348003347	putative homodimer-homodimer interface [polypeptide binding]; other site
632348003348	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
632348003349	This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822
632348003350	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
632348003351	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
632348003352	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
632348003353	S-adenosylmethionine binding site [chemical binding]; other site
632348003354	Uncharacterized conserved protein [Function unknown]; Region: COG0327
632348003355	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
632348003356	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
632348003357	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
632348003358	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
632348003359	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
632348003360	nucleotide binding pocket [chemical binding]; other site
632348003361	K-X-D-G motif; other site
632348003362	catalytic site [active]
632348003363	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
632348003364	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
632348003365	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
632348003366	Dimer interface [polypeptide binding]; other site
632348003367	BRCT sequence motif; other site
632348003368	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
632348003369	ABC1 family; Region: ABC1; cl17513
632348003370	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
632348003371	active site
632348003372	ATP binding site [chemical binding]; other site
632348003373	Uncharacterized conserved protein [Function unknown]; Region: COG3937
632348003374	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
632348003375	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
632348003376	dimer interface [polypeptide binding]; other site
632348003377	pyridoxal 5'-phosphate binding site [chemical binding]; other site
632348003378	catalytic residue [active]
632348003379	probable regulatory domain; Region: near_KaiC_dom; TIGR03879
632348003380	KaiC domain protein, AF_0795 family; Region: thermo_KaiC_2; TIGR03878
632348003381	KaiC; Region: KaiC; pfam06745
632348003382	Walker A motif; other site
632348003383	ATP binding site [chemical binding]; other site
632348003384	Walker B motif; other site
632348003385	Peptidase family M48; Region: Peptidase_M48; cl12018
632348003386	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
632348003387	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
632348003388	DNA binding residues [nucleotide binding]
632348003389	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
632348003390	catalytic residues [active]
632348003391	catalytic nucleophile [active]
632348003392	transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765
632348003393	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
632348003394	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
632348003395	Nuclease-related domain; Region: NERD; pfam08378
632348003396	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
632348003397	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
632348003398	ATP binding site [chemical binding]; other site
632348003399	putative Mg++ binding site [ion binding]; other site
632348003400	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
632348003401	nucleotide binding region [chemical binding]; other site
632348003402	ATP-binding site [chemical binding]; other site
632348003403	Protein of unknown function (DUF499); Region: DUF499; pfam04465
632348003404	Protein of unknown function (DUF3780); Region: DUF3780; pfam12635
632348003405	Protein of unknown function (DUF1156); Region: DUF1156; pfam06634
632348003406	Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743
632348003407	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_a; cd09179
632348003408	PLD-like domain; Region: PLDc_2; pfam13091
632348003409	putative active site [active]
632348003410	catalytic site [active]
632348003411	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
632348003412	ATP binding site [chemical binding]; other site
632348003413	putative Mg++ binding site [ion binding]; other site
632348003414	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
632348003415	nucleotide binding region [chemical binding]; other site
632348003416	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
632348003417	Walker A/P-loop; other site
632348003418	ATP binding site [chemical binding]; other site
632348003419	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
632348003420	ABC transporter signature motif; other site
632348003421	Walker B; other site
632348003422	D-loop; other site
632348003423	H-loop/switch region; other site
632348003424	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
632348003425	active site
632348003426	metal binding site [ion binding]; metal-binding site
632348003427	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
632348003428	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
632348003429	Walker A motif; other site
632348003430	ATP binding site [chemical binding]; other site
632348003431	Walker B motif; other site
632348003432	arginine finger; other site
632348003433	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
632348003434	binding surface
632348003435	TPR motif; other site
632348003436	TPR repeat; Region: TPR_11; pfam13414
632348003437	TPR repeat; Region: TPR_11; pfam13414
632348003438	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
632348003439	TPR motif; other site
632348003440	binding surface
632348003441	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
632348003442	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
632348003443	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
632348003444	Walker A motif; other site
632348003445	ATP binding site [chemical binding]; other site
632348003446	Walker B motif; other site
632348003447	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
632348003448	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
632348003449	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
632348003450	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
632348003451	Walker A/P-loop; other site
632348003452	ATP binding site [chemical binding]; other site
632348003453	Q-loop/lid; other site
632348003454	ABC transporter signature motif; other site
632348003455	Walker B; other site
632348003456	D-loop; other site
632348003457	H-loop/switch region; other site
632348003458	FtsX-like permease family; Region: FtsX; pfam02687
632348003459	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
632348003460	FtsX-like permease family; Region: FtsX; pfam02687
632348003461	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
632348003462	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
632348003463	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
632348003464	Walker A/P-loop; other site
632348003465	ATP binding site [chemical binding]; other site
632348003466	Q-loop/lid; other site
632348003467	ABC transporter signature motif; other site
632348003468	Walker B; other site
632348003469	D-loop; other site
632348003470	H-loop/switch region; other site
632348003471	Putative zinc-finger; Region: zf-HC2; pfam13490
632348003472	RNA polymerase sigma factor SigX; Provisional; Region: PRK09639
632348003473	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
632348003474	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
632348003475	DNA binding residues [nucleotide binding]
632348003476	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
632348003477	Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156
632348003478	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
632348003479	putative FMN binding site [chemical binding]; other site
632348003480	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093
632348003481	Flavin Reductases; Region: FlaRed; cl00801
632348003482	FeoA domain; Region: FeoA; pfam04023
632348003483	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
632348003484	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
632348003485	G1 box; other site
632348003486	GTP/Mg2+ binding site [chemical binding]; other site
632348003487	Switch I region; other site
632348003488	G2 box; other site
632348003489	G3 box; other site
632348003490	Switch II region; other site
632348003491	G4 box; other site
632348003492	G5 box; other site
632348003493	Nucleoside recognition; Region: Gate; pfam07670
632348003494	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
632348003495	Nucleoside recognition; Region: Gate; pfam07670
632348003496	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
632348003497	metal binding site 2 [ion binding]; metal-binding site
632348003498	putative DNA binding helix; other site
632348003499	metal binding site 1 [ion binding]; metal-binding site
632348003500	dimer interface [polypeptide binding]; other site
632348003501	structural Zn2+ binding site [ion binding]; other site
632348003502	Carbohydrate binding domain (family 25); Region: CBM_25; cl04060
632348003503	spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869
632348003504	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
632348003505	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
632348003506	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
632348003507	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
632348003508	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
632348003509	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
632348003510	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
632348003511	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
632348003512	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
632348003513	active site
632348003514	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
632348003515	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
632348003516	putative active site [active]
632348003517	putative metal binding site [ion binding]; other site
632348003518	GTP-binding protein LepA; Provisional; Region: PRK05433
632348003519	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
632348003520	G1 box; other site
632348003521	putative GEF interaction site [polypeptide binding]; other site
632348003522	GTP/Mg2+ binding site [chemical binding]; other site
632348003523	Switch I region; other site
632348003524	G2 box; other site
632348003525	G3 box; other site
632348003526	Switch II region; other site
632348003527	G4 box; other site
632348003528	G5 box; other site
632348003529	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
632348003530	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
632348003531	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
632348003532	coproporphyrinogen III oxidase; Provisional; Region: PRK05799
632348003533	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
632348003534	FeS/SAM binding site; other site
632348003535	HemN C-terminal domain; Region: HemN_C; pfam06969
632348003536	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
632348003537	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
632348003538	heat shock protein GrpE; Provisional; Region: PRK14140
632348003539	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
632348003540	dimer interface [polypeptide binding]; other site
632348003541	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
632348003542	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
632348003543	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
632348003544	nucleotide binding site [chemical binding]; other site
632348003545	NEF interaction site [polypeptide binding]; other site
632348003546	SBD interface [polypeptide binding]; other site
632348003547	Archaeal/vacuolar-type H+-ATPase subunit H [Energy production and conversion]; Region: NtpF; COG2811
632348003548	chaperone protein DnaJ; Provisional; Region: PRK14277
632348003549	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
632348003550	HSP70 interaction site [polypeptide binding]; other site
632348003551	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
632348003552	substrate binding site [polypeptide binding]; other site
632348003553	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
632348003554	Zn binding sites [ion binding]; other site
632348003555	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
632348003556	dimer interface [polypeptide binding]; other site
632348003557	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
632348003558	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
632348003559	S-adenosylmethionine binding site [chemical binding]; other site
632348003560	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
632348003561	RNA methyltransferase, RsmE family; Region: TIGR00046
632348003562	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
632348003563	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
632348003564	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
632348003565	catalytic residue [active]
632348003566	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
632348003567	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
632348003568	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
632348003569	Ligand Binding Site [chemical binding]; other site
632348003570	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
632348003571	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
632348003572	RNA binding surface [nucleotide binding]; other site
632348003573	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
632348003574	active site
632348003575	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
632348003576	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
632348003577	ornithine carbamoyltransferase; Provisional; Region: PRK00779
632348003578	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
632348003579	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
632348003580	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
632348003581	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
632348003582	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
632348003583	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
632348003584	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
632348003585	ATP-grasp domain; Region: ATP-grasp_4; cl17255
632348003586	MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245
632348003587	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
632348003588	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
632348003589	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
632348003590	catalytic site [active]
632348003591	subunit interface [polypeptide binding]; other site
632348003592	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
632348003593	active site
632348003594	asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536
632348003595	dimer interface [polypeptide binding]; other site
632348003596	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
632348003597	Ligand Binding Site [chemical binding]; other site
632348003598	Molecular Tunnel; other site
632348003599	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
632348003600	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
632348003601	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
632348003602	Transcriptional regulators [Transcription]; Region: GntR; COG1802
632348003603	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
632348003604	DNA-binding site [nucleotide binding]; DNA binding site
632348003605	FCD domain; Region: FCD; pfam07729
632348003606	MobA-like NTP transferase domain; Region: NTP_transf_3; pfam12804
632348003607	active site
632348003608	hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980
632348003609	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
632348003610	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
632348003611	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
632348003612	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
632348003613	putative homodimer interface [polypeptide binding]; other site
632348003614	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
632348003615	heterodimer interface [polypeptide binding]; other site
632348003616	homodimer interface [polypeptide binding]; other site
632348003617	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
632348003618	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
632348003619	23S rRNA interface [nucleotide binding]; other site
632348003620	L7/L12 interface [polypeptide binding]; other site
632348003621	putative thiostrepton binding site; other site
632348003622	L25 interface [polypeptide binding]; other site
632348003623	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
632348003624	mRNA/rRNA interface [nucleotide binding]; other site
632348003625	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
632348003626	23S rRNA interface [nucleotide binding]; other site
632348003627	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
632348003628	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
632348003629	core dimer interface [polypeptide binding]; other site
632348003630	peripheral dimer interface [polypeptide binding]; other site
632348003631	L10 interface [polypeptide binding]; other site
632348003632	L11 interface [polypeptide binding]; other site
632348003633	putative EF-Tu interaction site [polypeptide binding]; other site
632348003634	putative EF-G interaction site [polypeptide binding]; other site
632348003635	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
632348003636	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
632348003637	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
632348003638	Walker A/P-loop; other site
632348003639	ATP binding site [chemical binding]; other site
632348003640	Q-loop/lid; other site
632348003641	ABC transporter signature motif; other site
632348003642	Walker B; other site
632348003643	D-loop; other site
632348003644	H-loop/switch region; other site
632348003645	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
632348003646	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
632348003647	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
632348003648	Walker A/P-loop; other site
632348003649	ATP binding site [chemical binding]; other site
632348003650	Q-loop/lid; other site
632348003651	ABC transporter signature motif; other site
632348003652	Walker B; other site
632348003653	D-loop; other site
632348003654	H-loop/switch region; other site
632348003655	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
632348003656	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
632348003657	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
632348003658	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
632348003659	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
632348003660	motif II; other site
632348003661	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
632348003662	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
632348003663	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
632348003664	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
632348003665	Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524
632348003666	active site residue [active]
632348003667	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
632348003668	substrate binding site; other site
632348003669	dimer interface; other site
632348003670	Isopentenyl transferase; Region: IPT; pfam01745
632348003671	AAA domain; Region: AAA_32; pfam13654
632348003672	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
632348003673	RNA helicase; Region: RNA_helicase; pfam00910
632348003674	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
632348003675	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
632348003676	putative FMN binding site [chemical binding]; other site
632348003677	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
632348003678	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
632348003679	Cytidylyltransferase family; Region: CTP_transf_1; cl17467
632348003680	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
632348003681	GAF domain; Region: GAF_3; pfam13492
632348003682	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
632348003683	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
632348003684	metal binding site [ion binding]; metal-binding site
632348003685	active site
632348003686	I-site; other site
632348003687	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
632348003688	ATP cone domain; Region: ATP-cone; pfam03477
632348003689	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
632348003690	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
632348003691	putative dimer interface [polypeptide binding]; other site
632348003692	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
632348003693	Clp amino terminal domain; Region: Clp_N; pfam02861
632348003694	Clp amino terminal domain; Region: Clp_N; pfam02861
632348003695	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
632348003696	Walker A motif; other site
632348003697	ATP binding site [chemical binding]; other site
632348003698	Walker B motif; other site
632348003699	arginine finger; other site
632348003700	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
632348003701	Walker A motif; other site
632348003702	ATP binding site [chemical binding]; other site
632348003703	Walker B motif; other site
632348003704	arginine finger; other site
632348003705	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
632348003706	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
632348003707	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
632348003708	acyl-activating enzyme (AAE) consensus motif; other site
632348003709	AMP binding site [chemical binding]; other site
632348003710	active site
632348003711	CoA binding site [chemical binding]; other site
632348003712	indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336
632348003713	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
632348003714	dimer interface [polypeptide binding]; other site
632348003715	PYR/PP interface [polypeptide binding]; other site
632348003716	TPP binding site [chemical binding]; other site
632348003717	substrate binding site [chemical binding]; other site
632348003718	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
632348003719	TPP-binding site; other site
632348003720	4Fe-4S binding domain; Region: Fer4; pfam00037
632348003721	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
632348003722	indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853
632348003723	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
632348003724	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
632348003725	acyl-activating enzyme (AAE) consensus motif; other site
632348003726	AMP binding site [chemical binding]; other site
632348003727	active site
632348003728	CoA binding site [chemical binding]; other site
632348003729	ACT domain-containing protein [General function prediction only]; Region: COG4747
632348003730	N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908
632348003731	C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882
632348003732	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
632348003733	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328
632348003734	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
632348003735	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
632348003736	FeS/SAM binding site; other site
632348003737	TRAM domain; Region: TRAM; pfam01938
632348003738	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
632348003739	MutS domain I; Region: MutS_I; pfam01624
632348003740	MutS domain II; Region: MutS_II; pfam05188
632348003741	MutS domain III; Region: MutS_III; pfam05192
632348003742	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
632348003743	Walker A/P-loop; other site
632348003744	ATP binding site [chemical binding]; other site
632348003745	Q-loop/lid; other site
632348003746	ABC transporter signature motif; other site
632348003747	Walker B; other site
632348003748	D-loop; other site
632348003749	H-loop/switch region; other site
632348003750	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
632348003751	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
632348003752	ATP binding site [chemical binding]; other site
632348003753	Mg2+ binding site [ion binding]; other site
632348003754	G-X-G motif; other site
632348003755	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
632348003756	ATP binding site [chemical binding]; other site
632348003757	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
632348003758	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
632348003759	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
632348003760	bacterial Hfq-like; Region: Hfq; cd01716
632348003761	hexamer interface [polypeptide binding]; other site
632348003762	Sm1 motif; other site
632348003763	RNA binding site [nucleotide binding]; other site
632348003764	Sm2 motif; other site
632348003765	Aluminium resistance protein; Region: Alum_res; pfam06838
632348003766	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
632348003767	LexA repressor; Validated; Region: PRK00215
632348003768	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
632348003769	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
632348003770	Catalytic site [active]
632348003771	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
632348003772	propionate/acetate kinase; Provisional; Region: PRK12379
632348003773	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
632348003774	nucleotide binding site [chemical binding]; other site
632348003775	desulfoferrodoxin; Region: dfx_rbo; TIGR00320
632348003776	Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974
632348003777	non-heme iron binding site [ion binding]; other site
632348003778	dimer interface [polypeptide binding]; other site
632348003779	Superoxide reductase-like (SORL) domain, class I; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin.  Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_Dfx_classI; cd03171
632348003780	non-heme iron binding site [ion binding]; other site
632348003781	dimer interface [polypeptide binding]; other site
632348003782	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
632348003783	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
632348003784	active site
632348003785	HIGH motif; other site
632348003786	nucleotide binding site [chemical binding]; other site
632348003787	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
632348003788	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
632348003789	active site
632348003790	KMSKS motif; other site
632348003791	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
632348003792	tRNA binding surface [nucleotide binding]; other site
632348003793	anticodon binding site; other site
632348003794	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
632348003795	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
632348003796	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
632348003797	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
632348003798	active site
632348003799	intersubunit interactions; other site
632348003800	catalytic residue [active]
632348003801	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
632348003802	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
632348003803	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
632348003804	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632348003805	active site
632348003806	phosphorylation site [posttranslational modification]
632348003807	intermolecular recognition site; other site
632348003808	dimerization interface [polypeptide binding]; other site
632348003809	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
632348003810	DNA binding site [nucleotide binding]
632348003811	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
632348003812	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
632348003813	dimer interface [polypeptide binding]; other site
632348003814	phosphorylation site [posttranslational modification]
632348003815	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
632348003816	ATP binding site [chemical binding]; other site
632348003817	Mg2+ binding site [ion binding]; other site
632348003818	G-X-G motif; other site
632348003819	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
632348003820	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
632348003821	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
632348003822	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
632348003823	Walker A/P-loop; other site
632348003824	ATP binding site [chemical binding]; other site
632348003825	Q-loop/lid; other site
632348003826	ABC transporter signature motif; other site
632348003827	Walker B; other site
632348003828	D-loop; other site
632348003829	H-loop/switch region; other site
632348003830	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
632348003831	PhoU domain; Region: PhoU; pfam01895
632348003832	PhoU domain; Region: PhoU; pfam01895
632348003833	QueT transporter; Region: QueT; pfam06177
632348003834	ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443
632348003835	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
632348003836	dimer interface [polypeptide binding]; other site
632348003837	motif 1; other site
632348003838	active site
632348003839	motif 2; other site
632348003840	motif 3; other site
632348003841	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
632348003842	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
632348003843	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
632348003844	histidinol dehydrogenase; Region: hisD; TIGR00069
632348003845	NAD binding site [chemical binding]; other site
632348003846	dimerization interface [polypeptide binding]; other site
632348003847	product binding site; other site
632348003848	substrate binding site [chemical binding]; other site
632348003849	zinc binding site [ion binding]; other site
632348003850	catalytic residues [active]
632348003851	histidinol-phosphate aminotransferase; Provisional; Region: PRK03967
632348003852	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
632348003853	pyridoxal 5'-phosphate binding site [chemical binding]; other site
632348003854	homodimer interface [polypeptide binding]; other site
632348003855	catalytic residue [active]
632348003856	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
632348003857	putative active site pocket [active]
632348003858	4-fold oligomerization interface [polypeptide binding]; other site
632348003859	metal binding residues [ion binding]; metal-binding site
632348003860	3-fold/trimer interface [polypeptide binding]; other site
632348003861	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
632348003862	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
632348003863	putative active site [active]
632348003864	oxyanion strand; other site
632348003865	catalytic triad [active]
632348003866	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
632348003867	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
632348003868	catalytic residues [active]
632348003869	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
632348003870	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
632348003871	substrate binding site [chemical binding]; other site
632348003872	glutamase interaction surface [polypeptide binding]; other site
632348003873	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
632348003874	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
632348003875	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
632348003876	metal binding site [ion binding]; metal-binding site
632348003877	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
632348003878	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
632348003879	Substrate binding site; other site
632348003880	Cupin domain; Region: Cupin_2; cl17218
632348003881	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
632348003882	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
632348003883	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
632348003884	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
632348003885	Coenzyme A binding pocket [chemical binding]; other site
632348003886	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
632348003887	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
632348003888	minor groove reading motif; other site
632348003889	helix-hairpin-helix signature motif; other site
632348003890	substrate binding pocket [chemical binding]; other site
632348003891	active site
632348003892	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
632348003893	CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855
632348003894	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
632348003895	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
632348003896	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
632348003897	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
632348003898	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
632348003899	putative ATP binding site [chemical binding]; other site
632348003900	putative substrate interface [chemical binding]; other site
632348003901	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
632348003902	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
632348003903	NodB motif; other site
632348003904	active site
632348003905	catalytic site [active]
632348003906	metal binding site [ion binding]; metal-binding site
632348003907	single-stranded DNA-binding protein; Provisional; Region: PRK05813
632348003908	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
632348003909	dimer interface [polypeptide binding]; other site
632348003910	ssDNA binding site [nucleotide binding]; other site
632348003911	tetramer (dimer of dimers) interface [polypeptide binding]; other site
632348003912	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
632348003913	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypE; COG0309
632348003914	AIR synthase (PurM) related protein, subgroup 1 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like1; cd06061
632348003915	dimerization interface [polypeptide binding]; other site
632348003916	putative ATP binding site [chemical binding]; other site
632348003917	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
632348003918	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632348003919	active site
632348003920	phosphorylation site [posttranslational modification]
632348003921	intermolecular recognition site; other site
632348003922	dimerization interface [polypeptide binding]; other site
632348003923	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
632348003924	DNA binding site [nucleotide binding]
632348003925	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
632348003926	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
632348003927	dimerization interface [polypeptide binding]; other site
632348003928	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
632348003929	dimer interface [polypeptide binding]; other site
632348003930	phosphorylation site [posttranslational modification]
632348003931	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
632348003932	ATP binding site [chemical binding]; other site
632348003933	Mg2+ binding site [ion binding]; other site
632348003934	G-X-G motif; other site
632348003935	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
632348003936	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
632348003937	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
632348003938	protein binding site [polypeptide binding]; other site
632348003939	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
632348003940	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
632348003941	Sulfate transporter family; Region: Sulfate_transp; pfam00916
632348003942	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
632348003943	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
632348003944	ATP binding site [chemical binding]; other site
632348003945	active site
632348003946	substrate binding site [chemical binding]; other site
632348003947	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
632348003948	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
632348003949	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
632348003950	putative active site [active]
632348003951	catalytic triad [active]
632348003952	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
632348003953	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
632348003954	dimerization interface [polypeptide binding]; other site
632348003955	ATP binding site [chemical binding]; other site
632348003956	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
632348003957	dimerization interface [polypeptide binding]; other site
632348003958	ATP binding site [chemical binding]; other site
632348003959	amidophosphoribosyltransferase; Provisional; Region: PRK05793
632348003960	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
632348003961	active site
632348003962	tetramer interface [polypeptide binding]; other site
632348003963	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
632348003964	active site
632348003965	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
632348003966	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
632348003967	dimerization interface [polypeptide binding]; other site
632348003968	putative ATP binding site [chemical binding]; other site
632348003969	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
632348003970	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
632348003971	active site
632348003972	substrate binding site [chemical binding]; other site
632348003973	cosubstrate binding site; other site
632348003974	catalytic site [active]
632348003975	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
632348003976	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
632348003977	purine monophosphate binding site [chemical binding]; other site
632348003978	dimer interface [polypeptide binding]; other site
632348003979	putative catalytic residues [active]
632348003980	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
632348003981	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
632348003982	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
632348003983	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
632348003984	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
632348003985	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
632348003986	Rubredoxin [Energy production and conversion]; Region: COG1773
632348003987	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
632348003988	iron binding site [ion binding]; other site
632348003989	DNA polymerase I; Provisional; Region: PRK05755
632348003990	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
632348003991	active site
632348003992	metal binding site 1 [ion binding]; metal-binding site
632348003993	putative 5' ssDNA interaction site; other site
632348003994	metal binding site 3; metal-binding site
632348003995	metal binding site 2 [ion binding]; metal-binding site
632348003996	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
632348003997	putative DNA binding site [nucleotide binding]; other site
632348003998	putative metal binding site [ion binding]; other site
632348003999	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
632348004000	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
632348004001	active site
632348004002	DNA binding site [nucleotide binding]
632348004003	catalytic site [active]
632348004004	dephospho-CoA kinase; Region: TIGR00152
632348004005	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
632348004006	CoA-binding site [chemical binding]; other site
632348004007	ATP-binding [chemical binding]; other site
632348004008	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
632348004009	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
632348004010	N-acetyl-D-glucosamine binding site [chemical binding]; other site
632348004011	catalytic residue [active]
632348004012	excinuclease ABC subunit B; Provisional; Region: PRK05298
632348004013	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
632348004014	ATP binding site [chemical binding]; other site
632348004015	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
632348004016	nucleotide binding region [chemical binding]; other site
632348004017	ATP-binding site [chemical binding]; other site
632348004018	Ultra-violet resistance protein B; Region: UvrB; pfam12344
632348004019	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
632348004020	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
632348004021	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
632348004022	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
632348004023	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
632348004024	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
632348004025	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
632348004026	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
632348004027	Predicted permeases [General function prediction only]; Region: COG0679
632348004028	GMP synthase; Reviewed; Region: guaA; PRK00074
632348004029	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
632348004030	AMP/PPi binding site [chemical binding]; other site
632348004031	candidate oxyanion hole; other site
632348004032	catalytic triad [active]
632348004033	potential glutamine specificity residues [chemical binding]; other site
632348004034	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
632348004035	ATP Binding subdomain [chemical binding]; other site
632348004036	Ligand Binding sites [chemical binding]; other site
632348004037	Dimerization subdomain; other site
632348004038	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
632348004039	F0F1 ATP synthase subunit C; Provisional; Region: PRK13469
632348004040	F0F1 ATP synthase subunit B; Provisional; Region: PRK13461
632348004041	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
632348004042	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
632348004043	F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; COG0712
632348004044	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
632348004045	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
632348004046	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
632348004047	beta subunit interaction interface [polypeptide binding]; other site
632348004048	Walker A motif; other site
632348004049	ATP binding site [chemical binding]; other site
632348004050	Walker B motif; other site
632348004051	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
632348004052	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
632348004053	core domain interface [polypeptide binding]; other site
632348004054	delta subunit interface [polypeptide binding]; other site
632348004055	epsilon subunit interface [polypeptide binding]; other site
632348004056	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
632348004057	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
632348004058	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
632348004059	alpha subunit interaction interface [polypeptide binding]; other site
632348004060	Walker A motif; other site
632348004061	ATP binding site [chemical binding]; other site
632348004062	Walker B motif; other site
632348004063	inhibitor binding site; inhibition site
632348004064	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
632348004065	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
632348004066	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
632348004067	gamma subunit interface [polypeptide binding]; other site
632348004068	epsilon subunit interface [polypeptide binding]; other site
632348004069	LBP interface [polypeptide binding]; other site
632348004070	DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484
632348004071	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
632348004072	HSP70 interaction site [polypeptide binding]; other site
632348004073	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
632348004074	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
632348004075	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
632348004076	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
632348004077	trimer interface [polypeptide binding]; other site
632348004078	active site
632348004079	PRC-barrel domain containing protein [General function prediction only]; Region: COG3881
632348004080	Uncharacterized protein conserved in archaea (DUF2115); Region: DUF2115; cl01681
632348004081	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
632348004082	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
632348004083	AsnC family; Region: AsnC_trans_reg; pfam01037
632348004084	hypothetical protein; Validated; Region: PRK07682
632348004085	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
632348004086	pyridoxal 5'-phosphate binding site [chemical binding]; other site
632348004087	homodimer interface [polypeptide binding]; other site
632348004088	catalytic residue [active]
632348004089	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
632348004090	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
632348004091	active site
632348004092	GTPase Era; Reviewed; Region: era; PRK00089
632348004093	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
632348004094	G1 box; other site
632348004095	GTP/Mg2+ binding site [chemical binding]; other site
632348004096	Switch I region; other site
632348004097	G2 box; other site
632348004098	Switch II region; other site
632348004099	G3 box; other site
632348004100	G4 box; other site
632348004101	G5 box; other site
632348004102	KH domain; Region: KH_2; pfam07650
632348004103	Recombination protein O N terminal; Region: RecO_N; pfam11967
632348004104	DNA repair protein RecO; Region: reco; TIGR00613
632348004105	Recombination protein O C terminal; Region: RecO_C; pfam02565
632348004106	glycyl-tRNA synthetase; Provisional; Region: PRK04173
632348004107	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
632348004108	dimer interface [polypeptide binding]; other site
632348004109	motif 1; other site
632348004110	active site
632348004111	motif 2; other site
632348004112	motif 3; other site
632348004113	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
632348004114	anticodon binding site; other site
632348004115	pyruvate phosphate dikinase; Provisional; Region: PRK09279
632348004116	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
632348004117	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
632348004118	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
632348004119	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
632348004120	Predicted transcriptional regulator [Transcription]; Region: COG3388
632348004121	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
632348004122	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
632348004123	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
632348004124	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
632348004125	bifunctional phosphoglycerate kinase/triosephosphate isomerase; Provisional; Region: PRK13962
632348004126	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
632348004127	substrate binding site [chemical binding]; other site
632348004128	hinge regions; other site
632348004129	ADP binding site [chemical binding]; other site
632348004130	catalytic site [active]
632348004131	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
632348004132	substrate binding site [chemical binding]; other site
632348004133	dimer interface [polypeptide binding]; other site
632348004134	catalytic triad [active]
632348004135	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
632348004136	phosphoglyceromutase; Provisional; Region: PRK05434
632348004137	enolase; Provisional; Region: eno; PRK00077
632348004138	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
632348004139	dimer interface [polypeptide binding]; other site
632348004140	metal binding site [ion binding]; metal-binding site
632348004141	substrate binding pocket [chemical binding]; other site
632348004142	Glucuronate isomerase; Region: UxaC; pfam02614
632348004143	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
632348004144	PIN domains of VapC and Smg6 ribonucleases, ribosome assembly factor NOB1, Archaeoglobus fulgidus AF0591 protein and homologs; Region: PIN_VapC-Smg6-like; cd09855
632348004145	putative active site [active]
632348004146	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
632348004147	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
632348004148	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
632348004149	active site
632348004150	DNA binding site [nucleotide binding]
632348004151	Int/Topo IB signature motif; other site
632348004152	Uncharacterized conserved protein [Function unknown]; Region: COG1751
632348004153	Pyruvate kinase, alpha/beta domain; Region: PK_C; pfam02887
632348004154	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
632348004155	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
632348004156	putative ligand binding site [chemical binding]; other site
632348004157	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
632348004158	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
632348004159	TM-ABC transporter signature motif; other site
632348004160	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
632348004161	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
632348004162	TM-ABC transporter signature motif; other site
632348004163	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
632348004164	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
632348004165	Walker A/P-loop; other site
632348004166	ATP binding site [chemical binding]; other site
632348004167	Q-loop/lid; other site
632348004168	ABC transporter signature motif; other site
632348004169	Walker B; other site
632348004170	D-loop; other site
632348004171	H-loop/switch region; other site
632348004172	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
632348004173	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
632348004174	Walker A/P-loop; other site
632348004175	ATP binding site [chemical binding]; other site
632348004176	Q-loop/lid; other site
632348004177	ABC transporter signature motif; other site
632348004178	Walker B; other site
632348004179	D-loop; other site
632348004180	H-loop/switch region; other site
632348004181	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
632348004182	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
632348004183	Walker A/P-loop; other site
632348004184	ATP binding site [chemical binding]; other site
632348004185	Q-loop/lid; other site
632348004186	ABC transporter signature motif; other site
632348004187	Walker B; other site
632348004188	D-loop; other site
632348004189	H-loop/switch region; other site
632348004190	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
632348004191	active site
632348004192	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
632348004193	catalytic core [active]
632348004194	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
632348004195	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
632348004196	heterodimer interface [polypeptide binding]; other site
632348004197	active site
632348004198	FMN binding site [chemical binding]; other site
632348004199	homodimer interface [polypeptide binding]; other site
632348004200	substrate binding site [chemical binding]; other site
632348004201	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
632348004202	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
632348004203	FAD binding pocket [chemical binding]; other site
632348004204	FAD binding motif [chemical binding]; other site
632348004205	phosphate binding motif [ion binding]; other site
632348004206	beta-alpha-beta structure motif; other site
632348004207	NAD binding pocket [chemical binding]; other site
632348004208	Iron coordination center [ion binding]; other site
632348004209	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
632348004210	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
632348004211	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
632348004212	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
632348004213	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
632348004214	ATP-grasp domain; Region: ATP-grasp_4; cl17255
632348004215	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
632348004216	IMP binding site; other site
632348004217	dimer interface [polypeptide binding]; other site
632348004218	interdomain contacts; other site
632348004219	partial ornithine binding site; other site
632348004220	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
632348004221	active site
632348004222	dimer interface [polypeptide binding]; other site
632348004223	dihydroorotase; Validated; Region: pyrC; PRK09357
632348004224	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
632348004225	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
632348004226	active site
632348004227	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
632348004228	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
632348004229	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
632348004230	uracil transporter; Provisional; Region: PRK10720
632348004231	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
632348004232	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
632348004233	active site
632348004234	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
632348004235	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
632348004236	RNA binding surface [nucleotide binding]; other site
632348004237	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
632348004238	active site
632348004239	lipoprotein signal peptidase; Provisional; Region: PRK14787
632348004240	lipoprotein signal peptidase; Provisional; Region: PRK14791
632348004241	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
632348004242	metal ion-dependent adhesion site (MIDAS); other site
632348004243	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
632348004244	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
632348004245	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
632348004246	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
632348004247	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
632348004248	SnoaL-like domain; Region: SnoaL_4; cl17707
632348004249	Penicillinase repressor; Region: Pencillinase_R; cl17580
632348004250	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
632348004251	active site
632348004252	dimer interface [polypeptide binding]; other site
632348004253	metal binding site [ion binding]; metal-binding site
632348004254	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
632348004255	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
632348004256	HIGH motif; other site
632348004257	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
632348004258	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
632348004259	active site
632348004260	KMSKS motif; other site
632348004261	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
632348004262	tRNA binding surface [nucleotide binding]; other site
632348004263	anticodon binding site; other site
632348004264	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
632348004265	DivIVA protein; Region: DivIVA; pfam05103
632348004266	DivIVA domain; Region: DivI1A_domain; TIGR03544
632348004267	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
632348004268	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
632348004269	RNA binding surface [nucleotide binding]; other site
632348004270	YGGT family; Region: YGGT; pfam02325
632348004271	Protein of unknown function (DUF552); Region: DUF552; pfam04472
632348004272	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
632348004273	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
632348004274	catalytic residue [active]
632348004275	PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379
632348004276	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
632348004277	active site
632348004278	PHP-associated; Region: PHP_C; pfam13263
632348004279	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
632348004280	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
632348004281	dimer interface [polypeptide binding]; other site
632348004282	ADP-ribose binding site [chemical binding]; other site
632348004283	active site
632348004284	nudix motif; other site
632348004285	metal binding site [ion binding]; metal-binding site
632348004286	Protein of unknown function (DUF3866); Region: DUF3866; pfam12982
632348004287	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
632348004288	RNA/DNA hybrid binding site [nucleotide binding]; other site
632348004289	active site
632348004290	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
632348004291	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
632348004292	stage V sporulation protein B; Region: spore_V_B; TIGR02900
632348004293	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
632348004294	sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875
632348004295	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632348004296	active site
632348004297	phosphorylation site [posttranslational modification]
632348004298	intermolecular recognition site; other site
632348004299	dimerization interface [polypeptide binding]; other site
632348004300	Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769
632348004301	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
632348004302	SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580
632348004303	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
632348004304	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
632348004305	Walker A/P-loop; other site
632348004306	ATP binding site [chemical binding]; other site
632348004307	Q-loop/lid; other site
632348004308	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
632348004309	ABC transporter signature motif; other site
632348004310	Walker B; other site
632348004311	D-loop; other site
632348004312	H-loop/switch region; other site
632348004313	arginine repressor; Provisional; Region: argR; PRK00441
632348004314	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
632348004315	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
632348004316	NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061
632348004317	ATP-NAD kinase; Region: NAD_kinase; pfam01513
632348004318	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
632348004319	nucleotide binding site/active site [active]
632348004320	HIT family signature motif; other site
632348004321	catalytic residue [active]
632348004322	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
632348004323	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
632348004324	motif 1; other site
632348004325	active site
632348004326	motif 2; other site
632348004327	motif 3; other site
632348004328	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
632348004329	DHHA1 domain; Region: DHHA1; pfam02272
632348004330	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
632348004331	Domain of unknown function DUF20; Region: UPF0118; pfam01594
632348004332	PRC-barrel domain; Region: PRC; pfam05239
632348004333	4-hydroxy-3-methylbut-2-enyl diphosphate reductase/S1 RNA-binding domain protein; Reviewed; Region: PRK00087
632348004334	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
632348004335	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
632348004336	RNA binding site [nucleotide binding]; other site
632348004337	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
632348004338	RNA binding site [nucleotide binding]; other site
632348004339	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
632348004340	RNA binding site [nucleotide binding]; other site
632348004341	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
632348004342	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
632348004343	putative acyl-acceptor binding pocket; other site
632348004344	cytidylate kinase; Provisional; Region: cmk; PRK00023
632348004345	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
632348004346	CMP-binding site; other site
632348004347	The sites determining sugar specificity; other site
632348004348	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185
632348004349	homotrimer interaction site [polypeptide binding]; other site
632348004350	active site
632348004351	Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640
632348004352	hexamer interface [polypeptide binding]; other site
632348004353	RNA binding site [nucleotide binding]; other site
632348004354	Histidine-zinc binding site [chemical binding]; other site
632348004355	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
632348004356	catalytic core [active]
632348004357	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
632348004358	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
632348004359	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
632348004360	putative active site [active]
632348004361	Protein of unknown function (DUF4264); Region: DUF4264; pfam14084
632348004362	oxaloacetate decarboxylase; Provisional; Region: PRK12331
632348004363	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
632348004364	active site
632348004365	catalytic residues [active]
632348004366	metal binding site [ion binding]; metal-binding site
632348004367	homodimer binding site [polypeptide binding]; other site
632348004368	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06549
632348004369	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
632348004370	carboxyltransferase (CT) interaction site; other site
632348004371	biotinylation site [posttranslational modification]; other site
632348004372	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
632348004373	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
632348004374	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
632348004375	agmatinase; Region: agmatinase; TIGR01230
632348004376	Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593
632348004377	putative active site [active]
632348004378	Mn binding site [ion binding]; other site
632348004379	spermidine synthase; Provisional; Region: PRK00811
632348004380	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
632348004381	Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571
632348004382	Mg++ binding site [ion binding]; other site
632348004383	putative catalytic motif [active]
632348004384	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
632348004385	active site
632348004386	Protein of unknown function (DUF3186); Region: DUF3186; pfam11382
632348004387	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825
632348004388	Thiamine pyrophosphokinase; Region: TPK; cl08415
632348004389	Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555
632348004390	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
632348004391	active site
632348004392	dimer interfaces [polypeptide binding]; other site
632348004393	catalytic residues [active]
632348004394	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
632348004395	Septum formation topological specificity factor MinE; Region: MinE; cl00538
632348004396	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
632348004397	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
632348004398	P-loop; other site
632348004399	ADP binding residues [chemical binding]; other site
632348004400	Switch I; other site
632348004401	Switch II; other site
632348004402	septum formation inhibitor; Reviewed; Region: minC; PRK00513
632348004403	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
632348004404	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
632348004405	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
632348004406	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
632348004407	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
632348004408	rod shape-determining protein MreC; Provisional; Region: PRK13922
632348004409	rod shape-determining protein MreC; Region: MreC; pfam04085
632348004410	rod shape-determining protein MreB; Provisional; Region: PRK13927
632348004411	MreB and similar proteins; Region: MreB_like; cd10225
632348004412	nucleotide binding site [chemical binding]; other site
632348004413	Mg binding site [ion binding]; other site
632348004414	putative protofilament interaction site [polypeptide binding]; other site
632348004415	RodZ interaction site [polypeptide binding]; other site
632348004416	Maf-like protein; Region: Maf; pfam02545
632348004417	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
632348004418	active site
632348004419	dimer interface [polypeptide binding]; other site
632348004420	bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569
632348004421	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
632348004422	catalytic loop [active]
632348004423	iron binding site [ion binding]; other site
632348004424	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
632348004425	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
632348004426	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
632348004427	Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256
632348004428	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
632348004429	dimer interface [polypeptide binding]; other site
632348004430	[2Fe-2S] cluster binding site [ion binding]; other site
632348004431	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
632348004432	SLBB domain; Region: SLBB; pfam10531
632348004433	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
632348004434	4Fe-4S binding domain; Region: Fer4; pfam00037
632348004435	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
632348004436	4Fe-4S binding domain; Region: Fer4; pfam00037
632348004437	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
632348004438	dimer interface [polypeptide binding]; other site
632348004439	[2Fe-2S] cluster binding site [ion binding]; other site
632348004440	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
632348004441	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
632348004442	ATP binding site [chemical binding]; other site
632348004443	Mg2+ binding site [ion binding]; other site
632348004444	G-X-G motif; other site
632348004445	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
632348004446	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
632348004447	putative dimer interface [polypeptide binding]; other site
632348004448	[2Fe-2S] cluster binding site [ion binding]; other site
632348004449	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
632348004450	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
632348004451	active site
632348004452	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
632348004453	DRTGG domain; Region: DRTGG; pfam07085
632348004454	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
632348004455	4Fe-4S binding domain; Region: Fer4; pfam00037
632348004456	4Fe-4S binding domain; Region: Fer4; cl02805
632348004457	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
632348004458	Putative Fe-S cluster; Region: FeS; cl17515
632348004459	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
632348004460	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
632348004461	ATP binding site [chemical binding]; other site
632348004462	Mg2+ binding site [ion binding]; other site
632348004463	G-X-G motif; other site
632348004464	DRTGG domain; Region: DRTGG; pfam07085
632348004465	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
632348004466	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
632348004467	RNA binding surface [nucleotide binding]; other site
632348004468	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
632348004469	S-adenosylmethionine binding site [chemical binding]; other site
632348004470	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
632348004471	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
632348004472	TPP-binding site; other site
632348004473	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
632348004474	PYR/PP interface [polypeptide binding]; other site
632348004475	dimer interface [polypeptide binding]; other site
632348004476	TPP binding site [chemical binding]; other site
632348004477	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
632348004478	Divergent PAP2 family; Region: DUF212; pfam02681
632348004479	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
632348004480	Part of AAA domain; Region: AAA_19; pfam13245
632348004481	Family description; Region: UvrD_C_2; pfam13538
632348004482	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
632348004483	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
632348004484	putative tRNA-binding site [nucleotide binding]; other site
632348004485	B3/4 domain; Region: B3_4; pfam03483
632348004486	tRNA synthetase B5 domain; Region: B5; smart00874
632348004487	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
632348004488	dimer interface [polypeptide binding]; other site
632348004489	motif 1; other site
632348004490	motif 3; other site
632348004491	motif 2; other site
632348004492	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
632348004493	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
632348004494	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
632348004495	dimer interface [polypeptide binding]; other site
632348004496	motif 1; other site
632348004497	active site
632348004498	motif 2; other site
632348004499	motif 3; other site
632348004500	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
632348004501	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
632348004502	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
632348004503	FeS/SAM binding site; other site
632348004504	TRAM domain; Region: TRAM; cl01282
632348004505	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
632348004506	regulatory protein interface [polypeptide binding]; other site
632348004507	regulatory phosphorylation site [posttranslational modification]; other site
632348004508	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
632348004509	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
632348004510	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
632348004511	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
632348004512	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
632348004513	Tetramer interface [polypeptide binding]; other site
632348004514	active site
632348004515	FMN-binding site [chemical binding]; other site
632348004516	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
632348004517	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
632348004518	Beta-Casp domain; Region: Beta-Casp; smart01027
632348004519	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
632348004520	Protein of unknown function (DUF3048); Region: DUF3048; pfam11258
632348004521	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
632348004522	PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like phosphatase domains appear fused to E. coli DAGK-like trans-membrane diacylglycerol kinase domains. The cellular function of these architectures remains to be...; Region: PAP2_diacylglycerolkinase; cd03383
632348004523	active site
632348004524	metal-binding heat shock protein; Provisional; Region: PRK00016
632348004525	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
632348004526	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
632348004527	Zn2+ binding site [ion binding]; other site
632348004528	Mg2+ binding site [ion binding]; other site
632348004529	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
632348004530	PhoH-like protein; Region: PhoH; pfam02562
632348004531	Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898
632348004532	sporulation protein YqfD; Region: spore_yqfD; TIGR02876
632348004533	YabP family; Region: YabP; cl06766
632348004534	Yqey-like protein; Region: YqeY; pfam09424
632348004535	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
632348004536	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
632348004537	active site
632348004538	pyruvate kinase; Provisional; Region: PRK06354
632348004539	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
632348004540	domain interfaces; other site
632348004541	active site
632348004542	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
632348004543	6-phosphofructokinase; Provisional; Region: PRK03202
632348004544	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
632348004545	active site
632348004546	ADP/pyrophosphate binding site [chemical binding]; other site
632348004547	dimerization interface [polypeptide binding]; other site
632348004548	allosteric effector site; other site
632348004549	fructose-1,6-bisphosphate binding site; other site
632348004550	transcription attenuation protein MtrB; Provisional; Region: PRK13251
632348004551	DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826
632348004552	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
632348004553	active site
632348004554	PHP Thumb interface [polypeptide binding]; other site
632348004555	metal binding site [ion binding]; metal-binding site
632348004556	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
632348004557	generic binding surface II; other site
632348004558	generic binding surface I; other site
632348004559	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
632348004560	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
632348004561	Zn2+ binding site [ion binding]; other site
632348004562	Mg2+ binding site [ion binding]; other site
632348004563	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
632348004564	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
632348004565	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
632348004566	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
632348004567	SLBB domain; Region: SLBB; pfam10531
632348004568	comEA protein; Region: comE; TIGR01259
632348004569	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
632348004570	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
632348004571	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
632348004572	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
632348004573	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
632348004574	HIGH motif; other site
632348004575	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
632348004576	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
632348004577	active site
632348004578	KMSKS motif; other site
632348004579	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
632348004580	tRNA binding surface [nucleotide binding]; other site
632348004581	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
632348004582	Transcriptional regulator [Transcription]; Region: LytR; COG1316
632348004583	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
632348004584	Zn2+ binding site [ion binding]; other site
632348004585	Mg2+ binding site [ion binding]; other site
632348004586	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
632348004587	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
632348004588	active site
632348004589	(T/H)XGH motif; other site
632348004590	argininosuccinate synthase; Provisional; Region: PRK13820
632348004591	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
632348004592	ANP binding site [chemical binding]; other site
632348004593	Substrate Binding Site II [chemical binding]; other site
632348004594	Substrate Binding Site I [chemical binding]; other site
632348004595	argininosuccinate lyase; Provisional; Region: PRK00855
632348004596	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
632348004597	active sites [active]
632348004598	tetramer interface [polypeptide binding]; other site
632348004599	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
632348004600	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
632348004601	5S rRNA interface [nucleotide binding]; other site
632348004602	CTC domain interface [polypeptide binding]; other site
632348004603	L16 interface [polypeptide binding]; other site
632348004604	Protein of unknown function, DUF624; Region: DUF624; cl02369
632348004605	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
632348004606	Transcriptional regulator [Transcription]; Region: LytR; COG1316
632348004607	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
632348004608	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
632348004609	O-Antigen ligase; Region: Wzy_C; cl04850
632348004610	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
632348004611	putative trimer interface [polypeptide binding]; other site
632348004612	putative CoA binding site [chemical binding]; other site
632348004613	WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358
632348004614	putative trimer interface [polypeptide binding]; other site
632348004615	putative active site [active]
632348004616	putative substrate binding site [chemical binding]; other site
632348004617	putative CoA binding site [chemical binding]; other site
632348004618	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
632348004619	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
632348004620	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
632348004621	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
632348004622	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
632348004623	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
632348004624	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
632348004625	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
632348004626	inhibitor-cofactor binding pocket; inhibition site
632348004627	pyridoxal 5'-phosphate binding site [chemical binding]; other site
632348004628	catalytic residue [active]
632348004629	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
632348004630	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
632348004631	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
632348004632	Electron transfer flavoprotein domain; Region: ETF; smart00893
632348004633	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
632348004634	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
632348004635	Ligand binding site [chemical binding]; other site
632348004636	Electron transfer flavoprotein domain; Region: ETF; pfam01012
632348004637	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
632348004638	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
632348004639	FAD binding site [chemical binding]; other site
632348004640	homotetramer interface [polypeptide binding]; other site
632348004641	substrate binding pocket [chemical binding]; other site
632348004642	catalytic base [active]
632348004643	hypothetical protein; Provisional; Region: PRK13670
632348004644	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673
632348004645	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
632348004646	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
632348004647	active site
632348004648	nucleophile elbow; other site
632348004649	sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871
632348004650	phosphodiesterase; Provisional; Region: PRK12704
632348004651	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
632348004652	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
632348004653	active site
632348004654	(T/H)XGH motif; other site
632348004655	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
632348004656	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
632348004657	S-adenosylmethionine binding site [chemical binding]; other site
632348004658	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
632348004659	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
632348004660	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
632348004661	ssDNA binding site; other site
632348004662	generic binding surface II; other site
632348004663	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
632348004664	ATP binding site [chemical binding]; other site
632348004665	putative Mg++ binding site [ion binding]; other site
632348004666	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
632348004667	nucleotide binding region [chemical binding]; other site
632348004668	ATP-binding site [chemical binding]; other site
632348004669	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
632348004670	DAK2 domain; Region: Dak2; pfam02734
632348004671	Asp23 family; Region: Asp23; pfam03780
632348004672	Predicted membrane protein [Function unknown]; Region: COG3601
632348004673	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
632348004674	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
632348004675	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
632348004676	RNA binding surface [nucleotide binding]; other site
632348004677	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
632348004678	active site
632348004679	uracil binding [chemical binding]; other site
632348004680	rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933
632348004681	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
632348004682	S-adenosylmethionine binding site [chemical binding]; other site
632348004683	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
632348004684	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
632348004685	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
632348004686	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
632348004687	putative RNA binding site [nucleotide binding]; other site
632348004688	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
632348004689	S-adenosylmethionine binding site [chemical binding]; other site
632348004690	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
632348004691	nudix motif; other site
632348004692	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
632348004693	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
632348004694	GTP binding site; other site
632348004695	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
632348004696	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
632348004697	putative [4Fe-4S] binding site [ion binding]; other site
632348004698	putative molybdopterin cofactor binding site [chemical binding]; other site
632348004699	Molydopterin dinucleotide binding domain; Region: Molydop_binding; pfam01568
632348004700	molybdopterin cofactor binding site; other site
632348004701	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
632348004702	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
632348004703	dimerization interface [polypeptide binding]; other site
632348004704	active site
632348004705	L-aspartate oxidase; Provisional; Region: PRK06175
632348004706	Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029
632348004707	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
632348004708	Quinolinate synthetase A protein; Region: NadA; pfam02445
632348004709	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
632348004710	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
632348004711	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
632348004712	active site
632348004713	catalytic tetrad [active]
632348004714	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
632348004715	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
632348004716	hypothetical protein; Provisional; Region: PRK05473
632348004717	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
632348004718	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
632348004719	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
632348004720	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
632348004721	23S rRNA binding site [nucleotide binding]; other site
632348004722	L21 binding site [polypeptide binding]; other site
632348004723	L13 binding site [polypeptide binding]; other site
632348004724	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
632348004725	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
632348004726	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
632348004727	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
632348004728	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
632348004729	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
632348004730	Ligand Binding Site [chemical binding]; other site
632348004731	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
632348004732	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
632348004733	inhibitor-cofactor binding pocket; inhibition site
632348004734	pyridoxal 5'-phosphate binding site [chemical binding]; other site
632348004735	catalytic residue [active]
632348004736	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
632348004737	dimer interface [polypeptide binding]; other site
632348004738	active site
632348004739	Schiff base residues; other site
632348004740	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
632348004741	active site
632348004742	SAM binding site [chemical binding]; other site
632348004743	homodimer interface [polypeptide binding]; other site
632348004744	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
632348004745	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
632348004746	active site
632348004747	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
632348004748	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
632348004749	domain interfaces; other site
632348004750	active site
632348004751	precorrin-2 dehydrogenase; Provisional; Region: PRK05562
632348004752	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
632348004753	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
632348004754	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
632348004755	NAD(P) binding pocket [chemical binding]; other site
632348004756	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
632348004757	GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895
632348004758	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
632348004759	CysD dimerization site [polypeptide binding]; other site
632348004760	G1 box; other site
632348004761	putative GEF interaction site [polypeptide binding]; other site
632348004762	GTP/Mg2+ binding site [chemical binding]; other site
632348004763	Switch I region; other site
632348004764	G2 box; other site
632348004765	G3 box; other site
632348004766	Switch II region; other site
632348004767	G4 box; other site
632348004768	G5 box; other site
632348004769	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
632348004770	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
632348004771	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
632348004772	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
632348004773	Active Sites [active]
632348004774	Ferredoxin [Energy production and conversion]; Region: COG1146
632348004775	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
632348004776	adenylylsulfate reductase subunit alpha; Validated; Region: PRK06854
632348004777	L-aspartate oxidase; Provisional; Region: PRK06175
632348004778	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
632348004779	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
632348004780	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
632348004781	homodimer interface [polypeptide binding]; other site
632348004782	substrate-cofactor binding pocket; other site
632348004783	pyridoxal 5'-phosphate binding site [chemical binding]; other site
632348004784	catalytic residue [active]
632348004785	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
632348004786	CPxP  motif; other site
632348004787	sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912
632348004788	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
632348004789	4Fe-4S binding domain; Region: Fer4; pfam00037
632348004790	4Fe-4S binding domain; Region: Fer4; pfam00037
632348004791	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
632348004792	MPN+ (JAMM) motif; other site
632348004793	Zinc-binding site [ion binding]; other site
632348004794	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
632348004795	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
632348004796	ATP binding site [chemical binding]; other site
632348004797	substrate interface [chemical binding]; other site
632348004798	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
632348004799	thiS-thiF/thiG interaction site; other site
632348004800	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
632348004801	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632348004802	dimer interface [polypeptide binding]; other site
632348004803	conserved gate region; other site
632348004804	putative PBP binding loops; other site
632348004805	ABC-ATPase subunit interface; other site
632348004806	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
632348004807	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
632348004808	Walker A/P-loop; other site
632348004809	ATP binding site [chemical binding]; other site
632348004810	Q-loop/lid; other site
632348004811	ABC transporter signature motif; other site
632348004812	Walker B; other site
632348004813	D-loop; other site
632348004814	H-loop/switch region; other site
632348004815	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
632348004816	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
632348004817	substrate binding pocket [chemical binding]; other site
632348004818	membrane-bound complex binding site; other site
632348004819	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
632348004820	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
632348004821	putative substrate translocation pore; other site
632348004822	AIR carboxylase; Region: AIRC; pfam00731
632348004823	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
632348004824	ATP-grasp domain; Region: ATP-grasp; pfam02222
632348004825	Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057
632348004826	hybrid cluster protein; Provisional; Region: PRK05290
632348004827	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
632348004828	ACS interaction site; other site
632348004829	CODH interaction site; other site
632348004830	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
632348004831	hybrid metal cluster; other site
632348004832	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
632348004833	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
632348004834	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
632348004835	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
632348004836	ligand binding site [chemical binding]; other site
632348004837	flexible hinge region; other site
632348004838	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
632348004839	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
632348004840	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
632348004841	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
632348004842	P loop; other site
632348004843	GTP binding site [chemical binding]; other site
632348004844	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
632348004845	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
632348004846	Walker A/P-loop; other site
632348004847	ATP binding site [chemical binding]; other site
632348004848	Q-loop/lid; other site
632348004849	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
632348004850	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
632348004851	ABC transporter signature motif; other site
632348004852	Walker B; other site
632348004853	D-loop; other site
632348004854	H-loop/switch region; other site
632348004855	Putative amidase domain; Region: Amidase_6; pfam12671
632348004856	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
632348004857	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
632348004858	dimer interface [polypeptide binding]; other site
632348004859	catalytic residue [active]
632348004860	Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005
632348004861	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
632348004862	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632348004863	dimer interface [polypeptide binding]; other site
632348004864	conserved gate region; other site
632348004865	putative PBP binding loops; other site
632348004866	ABC-ATPase subunit interface; other site
632348004867	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
632348004868	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632348004869	dimer interface [polypeptide binding]; other site
632348004870	conserved gate region; other site
632348004871	putative PBP binding loops; other site
632348004872	ABC-ATPase subunit interface; other site
632348004873	PBP superfamily domain; Region: PBP_like_2; cl17296
632348004874	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
632348004875	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
632348004876	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
632348004877	FeS/SAM binding site; other site
632348004878	ribonuclease III; Reviewed; Region: rnc; PRK00102
632348004879	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
632348004880	dimerization interface [polypeptide binding]; other site
632348004881	active site
632348004882	metal binding site [ion binding]; metal-binding site
632348004883	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
632348004884	dsRNA binding site [nucleotide binding]; other site
632348004885	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
632348004886	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
632348004887	dimer interface [polypeptide binding]; other site
632348004888	active site
632348004889	acyl carrier protein; Provisional; Region: acpP; PRK00982
632348004890	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
632348004891	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
632348004892	NAD(P) binding site [chemical binding]; other site
632348004893	homotetramer interface [polypeptide binding]; other site
632348004894	homodimer interface [polypeptide binding]; other site
632348004895	active site
632348004896	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
632348004897	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
632348004898	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
632348004899	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
632348004900	dimer interface [polypeptide binding]; other site
632348004901	active site
632348004902	CoA binding pocket [chemical binding]; other site
632348004903	putative phosphate acyltransferase; Provisional; Region: PRK05331
632348004904	fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424
632348004905	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
632348004906	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
632348004907	active site 1 [active]
632348004908	active site 2 [active]
632348004909	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
632348004910	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
632348004911	active site
632348004912	tetramer interface; other site
632348004913	Protein of unknown function (DUF1292); Region: DUF1292; cl01608
632348004914	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
632348004915	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
632348004916	NAD(P) binding site [chemical binding]; other site
632348004917	active site
632348004918	recombination protein RecR; Reviewed; Region: recR; PRK00076
632348004919	RecR protein; Region: RecR; pfam02132
632348004920	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
632348004921	putative active site [active]
632348004922	putative metal-binding site [ion binding]; other site
632348004923	tetramer interface [polypeptide binding]; other site
632348004924	hypothetical protein; Validated; Region: PRK00153
632348004925	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
632348004926	AAA domain; Region: AAA_23; pfam13476
632348004927	Walker A/P-loop; other site
632348004928	ATP binding site [chemical binding]; other site
632348004929	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
632348004930	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
632348004931	ABC transporter signature motif; other site
632348004932	Walker B; other site
632348004933	D-loop; other site
632348004934	H-loop/switch region; other site
632348004935	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
632348004936	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
632348004937	active site
632348004938	metal binding site [ion binding]; metal-binding site
632348004939	DNA binding site [nucleotide binding]
632348004940	HerA helicase [Replication, recombination, and repair]; Region: COG0433
632348004941	Domain of unknown function DUF87; Region: DUF87; pfam01935
632348004942	NurA nuclease; Region: NurA; smart00933
632348004943	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
632348004944	homotrimer interaction site [polypeptide binding]; other site
632348004945	zinc binding site [ion binding]; other site
632348004946	CDP-binding sites; other site
632348004947	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
632348004948	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
632348004949	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
632348004950	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
632348004951	dihydrodipicolinate synthase; Region: dapA; TIGR00674
632348004952	dimer interface [polypeptide binding]; other site
632348004953	active site
632348004954	catalytic residue [active]
632348004955	dihydrodipicolinate reductase; Provisional; Region: PRK00048
632348004956	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
632348004957	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
632348004958	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
632348004959	putative allosteric regulatory site; other site
632348004960	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
632348004961	putative allosteric regulatory residue; other site
632348004962	reverse gyrase; Reviewed; Region: PRK09401
632348004963	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
632348004964	ATP binding site [chemical binding]; other site
632348004965	TopoIA_RevGyr : The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to the ATP-dependent reverse gyrase found in archaea and thermophilic bacteria. Type IA DNA topoisomerases remove; Region: TOPRIM_TopoIA_RevGyr; cd03361
632348004966	active site
632348004967	putative interdomain interaction site [polypeptide binding]; other site
632348004968	putative metal-binding site [ion binding]; other site
632348004969	putative nucleotide binding site [chemical binding]; other site
632348004970	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
632348004971	domain I; other site
632348004972	DNA binding groove [nucleotide binding]
632348004973	phosphate binding site [ion binding]; other site
632348004974	domain II; other site
632348004975	domain III; other site
632348004976	nucleotide binding site [chemical binding]; other site
632348004977	catalytic site [active]
632348004978	domain IV; other site
632348004979	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
632348004980	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
632348004981	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
632348004982	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
632348004983	dimer interface [polypeptide binding]; other site
632348004984	putative CheW interface [polypeptide binding]; other site
632348004985	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
632348004986	Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302
632348004987	tetramer interface [polypeptide binding]; other site
632348004988	active site
632348004989	aspartate aminotransferase; Provisional; Region: PRK05764
632348004990	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
632348004991	pyridoxal 5'-phosphate binding site [chemical binding]; other site
632348004992	homodimer interface [polypeptide binding]; other site
632348004993	catalytic residue [active]
632348004994	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
632348004995	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
632348004996	active site
632348004997	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
632348004998	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
632348004999	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
632348005000	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
632348005001	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
632348005002	homodimer interface [polypeptide binding]; other site
632348005003	substrate-cofactor binding pocket; other site
632348005004	pyridoxal 5'-phosphate binding site [chemical binding]; other site
632348005005	catalytic residue [active]
632348005006	CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985
632348005007	GTPase CgtA; Reviewed; Region: obgE; PRK12297
632348005008	GTP1/OBG; Region: GTP1_OBG; pfam01018
632348005009	Obg GTPase; Region: Obg; cd01898
632348005010	G1 box; other site
632348005011	GTP/Mg2+ binding site [chemical binding]; other site
632348005012	Switch I region; other site
632348005013	G2 box; other site
632348005014	G3 box; other site
632348005015	Switch II region; other site
632348005016	G4 box; other site
632348005017	G5 box; other site
632348005018	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
632348005019	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
632348005020	hypothetical protein; Provisional; Region: PRK14553
632348005021	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
632348005022	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
632348005023	Uncharacterized BCR, COG1636; Region: DUF208; pfam02677
632348005024	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
632348005025	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
632348005026	Walker A motif; other site
632348005027	ATP binding site [chemical binding]; other site
632348005028	Walker B motif; other site
632348005029	arginine finger; other site
632348005030	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
632348005031	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
632348005032	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
632348005033	active site
632348005034	putative DNA-binding cleft [nucleotide binding]; other site
632348005035	dimer interface [polypeptide binding]; other site
632348005036	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
632348005037	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
632348005038	Coenzyme A binding pocket [chemical binding]; other site
632348005039	alpha-galactosidase; Provisional; Region: PRK15076
632348005040	Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297
632348005041	NAD binding site [chemical binding]; other site
632348005042	sugar binding site [chemical binding]; other site
632348005043	divalent metal binding site [ion binding]; other site
632348005044	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
632348005045	dimer interface [polypeptide binding]; other site
632348005046	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
632348005047	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
632348005048	Predicted transcriptional regulator [Transcription]; Region: COG4189
632348005049	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
632348005050	dimerization interface [polypeptide binding]; other site
632348005051	putative DNA binding site [nucleotide binding]; other site
632348005052	putative Zn2+ binding site [ion binding]; other site
632348005053	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
632348005054	Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986
632348005055	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655
632348005056	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
632348005057	VanW like protein; Region: VanW; pfam04294
632348005058	G5 domain; Region: G5; pfam07501
632348005059	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558
632348005060	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013
632348005061	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
632348005062	TPP-binding site [chemical binding]; other site
632348005063	2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119
632348005064	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
632348005065	dimer interface [polypeptide binding]; other site
632348005066	PYR/PP interface [polypeptide binding]; other site
632348005067	TPP binding site [chemical binding]; other site
632348005068	substrate binding site [chemical binding]; other site
632348005069	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
632348005070	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
632348005071	MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149
632348005072	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
632348005073	dimerization interface [polypeptide binding]; other site
632348005074	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
632348005075	ATP binding site [chemical binding]; other site
632348005076	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
632348005077	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
632348005078	HupF/HypC family; Region: HupF_HypC; pfam01455
632348005079	Acylphosphatase; Region: Acylphosphatase; pfam00708
632348005080	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
632348005081	HypF finger; Region: zf-HYPF; pfam07503
632348005082	HypF finger; Region: zf-HYPF; pfam07503
632348005083	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
632348005084	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
632348005085	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
632348005086	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
632348005087	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
632348005088	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
632348005089	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
632348005090	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
632348005091	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329
632348005092	Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260
632348005093	NADH dehydrogenase; Region: NADHdh; cl00469
632348005094	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
632348005095	Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion / Inorganic ion transport and metabolism]; Region: HyfB; COG0651
632348005096	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
632348005097	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
632348005098	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
632348005099	active site
632348005100	motif I; other site
632348005101	motif II; other site
632348005102	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
632348005103	AMIN domain; Region: AMIN; pfam11741
632348005104	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
632348005105	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
632348005106	active site
632348005107	metal binding site [ion binding]; metal-binding site
632348005108	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
632348005109	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
632348005110	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
632348005111	feedback inhibition sensing region; other site
632348005112	homohexameric interface [polypeptide binding]; other site
632348005113	nucleotide binding site [chemical binding]; other site
632348005114	N-acetyl-L-glutamate binding site [chemical binding]; other site
632348005115	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
632348005116	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
632348005117	Low molecular weight phosphatase family; Region: LMWPc; cd00115
632348005118	active site
632348005119	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
632348005120	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
632348005121	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
632348005122	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
632348005123	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
632348005124	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
632348005125	ligand binding site [chemical binding]; other site
632348005126	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
632348005127	flagellar motor protein MotA; Validated; Region: PRK08124
632348005128	peptide chain release factor 1; Validated; Region: prfA; PRK00591
632348005129	This domain is found in peptide chain release factors; Region: PCRF; smart00937
632348005130	RF-1 domain; Region: RF-1; pfam00472
632348005131	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
632348005132	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
632348005133	S-adenosylmethionine binding site [chemical binding]; other site
632348005134	Protein of unknown function (DUF1385); Region: DUF1385; pfam07136
632348005135	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
632348005136	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
632348005137	putative substrate translocation pore; other site
632348005138	Major Facilitator Superfamily; Region: MFS_1; pfam07690
632348005139	Protease prsW family; Region: PrsW-protease; pfam13367
632348005140	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
632348005141	8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934
632348005142	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
632348005143	minor groove reading motif; other site
632348005144	helix-hairpin-helix signature motif; other site
632348005145	substrate binding pocket [chemical binding]; other site
632348005146	active site
632348005147	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
632348005148	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
632348005149	active site
632348005150	metal binding site [ion binding]; metal-binding site
632348005151	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
632348005152	transcription termination factor Rho; Provisional; Region: PRK12608
632348005153	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
632348005154	RNA binding site [nucleotide binding]; other site
632348005155	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
632348005156	Walker A motif; other site
632348005157	ATP binding site [chemical binding]; other site
632348005158	Walker B motif; other site
632348005159	Malic enzyme, N-terminal domain; Region: malic; pfam00390
632348005160	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
632348005161	putative NAD(P) binding site [chemical binding]; other site
632348005162	recombination factor protein RarA; Reviewed; Region: PRK13342
632348005163	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
632348005164	Walker A motif; other site
632348005165	ATP binding site [chemical binding]; other site
632348005166	Walker B motif; other site
632348005167	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
632348005168	arginine finger; other site
632348005169	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
632348005170	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
632348005171	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
632348005172	dimer interface [polypeptide binding]; other site
632348005173	active site
632348005174	glycine-pyridoxal phosphate binding site [chemical binding]; other site
632348005175	folate binding site [chemical binding]; other site
632348005176	Uncharacterized conserved protein [Function unknown]; Region: COG2966
632348005177	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
632348005178	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
632348005179	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
632348005180	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
632348005181	RNase E interface [polypeptide binding]; other site
632348005182	trimer interface [polypeptide binding]; other site
632348005183	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
632348005184	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
632348005185	RNase E interface [polypeptide binding]; other site
632348005186	trimer interface [polypeptide binding]; other site
632348005187	active site
632348005188	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
632348005189	putative nucleic acid binding region [nucleotide binding]; other site
632348005190	G-X-X-G motif; other site
632348005191	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
632348005192	RNA binding site [nucleotide binding]; other site
632348005193	domain interface; other site
632348005194	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
632348005195	16S/18S rRNA binding site [nucleotide binding]; other site
632348005196	S13e-L30e interaction site [polypeptide binding]; other site
632348005197	25S rRNA binding site [nucleotide binding]; other site
632348005198	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
632348005199	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
632348005200	active site
632348005201	Riboflavin kinase; Region: Flavokinase; pfam01687
632348005202	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130
632348005203	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
632348005204	RNA binding site [nucleotide binding]; other site
632348005205	active site
632348005206	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
632348005207	DHH family; Region: DHH; pfam01368
632348005208	DHHA1 domain; Region: DHHA1; pfam02272
632348005209	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
632348005210	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
632348005211	translation initiation factor IF-2; Region: IF-2; TIGR00487
632348005212	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
632348005213	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
632348005214	G1 box; other site
632348005215	putative GEF interaction site [polypeptide binding]; other site
632348005216	GTP/Mg2+ binding site [chemical binding]; other site
632348005217	Switch I region; other site
632348005218	G2 box; other site
632348005219	G3 box; other site
632348005220	Switch II region; other site
632348005221	G4 box; other site
632348005222	G5 box; other site
632348005223	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
632348005224	Translation-initiation factor 2; Region: IF-2; pfam11987
632348005225	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
632348005226	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
632348005227	putative RNA binding cleft [nucleotide binding]; other site
632348005228	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
632348005229	NusA N-terminal domain; Region: NusA_N; pfam08529
632348005230	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
632348005231	RNA binding site [nucleotide binding]; other site
632348005232	homodimer interface [polypeptide binding]; other site
632348005233	NusA-like KH domain; Region: KH_5; pfam13184
632348005234	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
632348005235	G-X-X-G motif; other site
632348005236	ribosome maturation protein RimP; Reviewed; Region: PRK00092
632348005237	Sm and related proteins; Region: Sm_like; cl00259
632348005238	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
632348005239	putative oligomer interface [polypeptide binding]; other site
632348005240	putative RNA binding site [nucleotide binding]; other site
632348005241	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
632348005242	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
632348005243	substrate binding site [chemical binding]; other site
632348005244	hexamer interface [polypeptide binding]; other site
632348005245	metal binding site [ion binding]; metal-binding site
632348005246	GTPase RsgA; Reviewed; Region: PRK00098
632348005247	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
632348005248	RNA binding site [nucleotide binding]; other site
632348005249	homodimer interface [polypeptide binding]; other site
632348005250	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
632348005251	GTP/Mg2+ binding site [chemical binding]; other site
632348005252	G4 box; other site
632348005253	G5 box; other site
632348005254	G1 box; other site
632348005255	Switch I region; other site
632348005256	G2 box; other site
632348005257	G3 box; other site
632348005258	Switch II region; other site
632348005259	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
632348005260	Catalytic domain of Protein Kinases; Region: PKc; cd00180
632348005261	active site
632348005262	ATP binding site [chemical binding]; other site
632348005263	substrate binding site [chemical binding]; other site
632348005264	activation loop (A-loop); other site
632348005265	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
632348005266	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
632348005267	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
632348005268	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
632348005269	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
632348005270	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
632348005271	Protein phosphatase 2C; Region: PP2C; pfam00481
632348005272	active site
632348005273	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454
632348005274	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
632348005275	FeS/SAM binding site; other site
632348005276	16S rRNA methyltransferase B; Provisional; Region: PRK14902
632348005277	NusB family; Region: NusB; pfam01029
632348005278	putative RNA binding site [nucleotide binding]; other site
632348005279	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
632348005280	S-adenosylmethionine binding site [chemical binding]; other site
632348005281	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298
632348005282	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
632348005283	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
632348005284	putative active site [active]
632348005285	substrate binding site [chemical binding]; other site
632348005286	putative cosubstrate binding site; other site
632348005287	catalytic site [active]
632348005288	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
632348005289	substrate binding site [chemical binding]; other site
632348005290	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
632348005291	active site
632348005292	catalytic residues [active]
632348005293	metal binding site [ion binding]; metal-binding site
632348005294	primosome assembly protein PriA; Validated; Region: PRK05580
632348005295	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
632348005296	ATP binding site [chemical binding]; other site
632348005297	putative Mg++ binding site [ion binding]; other site
632348005298	helicase superfamily c-terminal domain; Region: HELICc; smart00490
632348005299	ATP-binding site [chemical binding]; other site
632348005300	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
632348005301	Flavoprotein; Region: Flavoprotein; pfam02441
632348005302	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
632348005303	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
632348005304	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
632348005305	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
632348005306	catalytic site [active]
632348005307	G-X2-G-X-G-K; other site
632348005308	hypothetical protein; Provisional; Region: PRK04323
632348005309	hypothetical protein; Provisional; Region: PRK11820
632348005310	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
632348005311	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
632348005312	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
632348005313	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
632348005314	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
632348005315	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992
632348005316	active site
632348005317	Zn binding site [ion binding]; other site
632348005318	Protein of unknown function DUF89; Region: DUF89; cl15397
632348005319	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
632348005320	putative active site [active]
632348005321	CoA binding domain; Region: CoA_binding_2; pfam13380
632348005322	Domain of unknown function (DUF4363); Region: DUF4363; pfam14276
632348005323	Predicted membrane protein [Function unknown]; Region: COG2323
632348005324	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
632348005325	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
632348005326	acyl-activating enzyme (AAE) consensus motif; other site
632348005327	AMP binding site [chemical binding]; other site
632348005328	active site
632348005329	CoA binding site [chemical binding]; other site
632348005330	indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853
632348005331	indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336
632348005332	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
632348005333	dimer interface [polypeptide binding]; other site
632348005334	PYR/PP interface [polypeptide binding]; other site
632348005335	TPP binding site [chemical binding]; other site
632348005336	substrate binding site [chemical binding]; other site
632348005337	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
632348005338	TPP-binding site; other site
632348005339	4Fe-4S binding domain; Region: Fer4; pfam00037
632348005340	stage V sporulation protein T; Region: spore_V_T; TIGR02851
632348005341	looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439
632348005342	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
632348005343	putative substrate translocation pore; other site
632348005344	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
632348005345	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
632348005346	substrate binding pocket [chemical binding]; other site
632348005347	chain length determination region; other site
632348005348	substrate-Mg2+ binding site; other site
632348005349	catalytic residues [active]
632348005350	aspartate-rich region 1; other site
632348005351	active site lid residues [active]
632348005352	aspartate-rich region 2; other site
632348005353	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
632348005354	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
632348005355	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
632348005356	generic binding surface II; other site
632348005357	generic binding surface I; other site
632348005358	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
632348005359	Small integral membrane protein (DUF2273); Region: DUF2273; cl11575
632348005360	Asp23 family; Region: Asp23; cl00574
632348005361	Asp23 family; Region: Asp23; pfam03780
632348005362	SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685
632348005363	stage III sporulation protein AG; Region: spore_III_AG; TIGR02830
632348005364	Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581
632348005365	Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771
632348005366	Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961
632348005367	Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961
632348005368	Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961
632348005369	Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; cl08022
632348005370	stage III sporulation protein AA; Region: spore_III_AA; TIGR02858
632348005371	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
632348005372	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
632348005373	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
632348005374	putative active site [active]
632348005375	metal binding site [ion binding]; metal-binding site
632348005376	homodimer binding site [polypeptide binding]; other site
632348005377	phosphodiesterase; Provisional; Region: PRK12704
632348005378	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl17245
632348005379	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
632348005380	Zn2+ binding site [ion binding]; other site
632348005381	Mg2+ binding site [ion binding]; other site
632348005382	recombinase A; Provisional; Region: recA; PRK09354
632348005383	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
632348005384	hexamer interface [polypeptide binding]; other site
632348005385	Walker A motif; other site
632348005386	ATP binding site [chemical binding]; other site
632348005387	Walker B motif; other site
632348005388	competence damage-inducible protein A; Provisional; Region: PRK00549
632348005389	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
632348005390	putative MPT binding site; other site
632348005391	Competence-damaged protein; Region: CinA; pfam02464
632348005392	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
632348005393	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
632348005394	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
632348005395	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
632348005396	FeS/SAM binding site; other site
632348005397	TRAM domain; Region: TRAM; cl01282
632348005398	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190
632348005399	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
632348005400	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
632348005401	homodimer interface [polypeptide binding]; other site
632348005402	NADP binding site [chemical binding]; other site
632348005403	substrate binding site [chemical binding]; other site
632348005404	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
632348005405	hypothetical protein; Provisional; Region: PRK00955
632348005406	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
632348005407	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
632348005408	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
632348005409	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
632348005410	dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305
632348005411	dipicolinate synthase subunit A; Reviewed; Region: PRK08306
632348005412	D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; Region: 2-Hacid_dh_C; pfam02826
632348005413	hypothetical protein; Reviewed; Region: PRK12497
632348005414	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
632348005415	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
632348005416	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
632348005417	RNA/DNA hybrid binding site [nucleotide binding]; other site
632348005418	active site
632348005419	ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596
632348005420	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
632348005421	GTP/Mg2+ binding site [chemical binding]; other site
632348005422	G4 box; other site
632348005423	G5 box; other site
632348005424	G1 box; other site
632348005425	Switch I region; other site
632348005426	G2 box; other site
632348005427	G3 box; other site
632348005428	Switch II region; other site
632348005429	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
632348005430	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
632348005431	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
632348005432	RimM N-terminal domain; Region: RimM; pfam01782
632348005433	PRC-barrel domain; Region: PRC; pfam05239
632348005434	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
632348005435	KH-II  (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins  (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098
632348005436	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
632348005437	signal recognition particle protein; Provisional; Region: PRK10867
632348005438	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
632348005439	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
632348005440	P loop; other site
632348005441	GTP binding site [chemical binding]; other site
632348005442	Signal peptide binding domain; Region: SRP_SPB; pfam02978
632348005443	putative DNA-binding protein; Validated; Region: PRK00118
632348005444	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
632348005445	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
632348005446	Walker A/P-loop; other site
632348005447	ATP binding site [chemical binding]; other site
632348005448	Q-loop/lid; other site
632348005449	ABC transporter signature motif; other site
632348005450	Walker B; other site
632348005451	D-loop; other site
632348005452	H-loop/switch region; other site
632348005453	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
632348005454	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
632348005455	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
632348005456	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
632348005457	DNA-binding site [nucleotide binding]; DNA binding site
632348005458	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
632348005459	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
632348005460	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
632348005461	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
632348005462	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
632348005463	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
632348005464	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
632348005465	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
632348005466	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
632348005467	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
632348005468	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
632348005469	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
632348005470	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
632348005471	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
632348005472	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
632348005473	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
632348005474	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
632348005475	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
632348005476	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
632348005477	HIGH motif; other site
632348005478	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
632348005479	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
632348005480	active site
632348005481	HIGH motif; other site
632348005482	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
632348005483	active site
632348005484	KMSKS motif; other site
632348005485	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
632348005486	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
632348005487	NAD binding site [chemical binding]; other site
632348005488	homodimer interface [polypeptide binding]; other site
632348005489	active site
632348005490	substrate binding site [chemical binding]; other site
632348005491	galactokinase; Provisional; Region: PRK05322
632348005492	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
632348005493	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
632348005494	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
632348005495	Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085
632348005496	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
632348005497	dimer interface [polypeptide binding]; other site
632348005498	active site
632348005499	Sensory domain found in PocR; Region: PocR; pfam10114
632348005500	Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936
632348005501	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632348005502	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
632348005503	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632348005504	Uncharacterized conserved protein [Function unknown]; Region: COG1683
632348005505	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
632348005506	G1 box; other site
632348005507	GTP/Mg2+ binding site [chemical binding]; other site
632348005508	Switch I region; other site
632348005509	G2 box; other site
632348005510	G3 box; other site
632348005511	Switch II region; other site
632348005512	G4 box; other site
632348005513	G5 box; other site
632348005514	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
632348005515	Found in ATP-dependent protease La (LON); Region: LON; smart00464
632348005516	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
632348005517	Walker A motif; other site
632348005518	ATP binding site [chemical binding]; other site
632348005519	Walker B motif; other site
632348005520	arginine finger; other site
632348005521	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
632348005522	Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852
632348005523	Protein of unknown function (DUF1667); Region: DUF1667; pfam07892
632348005524	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
632348005525	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
632348005526	hydroxyglutarate oxidase; Provisional; Region: PRK11728
632348005527	Predicted dehydrogenase [General function prediction only]; Region: COG0579
632348005528	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
632348005529	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
632348005530	1,3-propanediol dehydrogenase-like (PPD); Region: PPD-like; cd08181
632348005531	dimer interface [polypeptide binding]; other site
632348005532	active site
632348005533	metal binding site [ion binding]; metal-binding site
632348005534	Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182
632348005535	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
632348005536	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
632348005537	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
632348005538	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
632348005539	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
632348005540	Walker A/P-loop; other site
632348005541	ATP binding site [chemical binding]; other site
632348005542	Q-loop/lid; other site
632348005543	ABC transporter signature motif; other site
632348005544	Walker B; other site
632348005545	D-loop; other site
632348005546	H-loop/switch region; other site
632348005547	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
632348005548	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
632348005549	Walker A/P-loop; other site
632348005550	ATP binding site [chemical binding]; other site
632348005551	Q-loop/lid; other site
632348005552	ABC transporter signature motif; other site
632348005553	Walker B; other site
632348005554	D-loop; other site
632348005555	H-loop/switch region; other site
632348005556	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
632348005557	active site
632348005558	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
632348005559	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
632348005560	FeS/SAM binding site; other site
632348005561	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
632348005562	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
632348005563	Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471
632348005564	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
632348005565	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
632348005566	Putative amidase domain; Region: Amidase_6; pfam12671
632348005567	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
632348005568	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
632348005569	active site
632348005570	HIGH motif; other site
632348005571	dimer interface [polypeptide binding]; other site
632348005572	KMSKS motif; other site
632348005573	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
632348005574	RNA binding surface [nucleotide binding]; other site
632348005575	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
632348005576	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
632348005577	N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038
632348005578	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
632348005579	active site
632348005580	putative substrate binding pocket [chemical binding]; other site
632348005581	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
632348005582	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
632348005583	homotetramer interface [polypeptide binding]; other site
632348005584	ligand binding site [chemical binding]; other site
632348005585	catalytic site [active]
632348005586	NAD binding site [chemical binding]; other site
632348005587	replicative DNA helicase; Region: DnaB; TIGR00665
632348005588	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
632348005589	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
632348005590	Walker A motif; other site
632348005591	ATP binding site [chemical binding]; other site
632348005592	Walker B motif; other site
632348005593	DNA binding loops [nucleotide binding]
632348005594	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
632348005595	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
632348005596	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
632348005597	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
632348005598	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
632348005599	DHH family; Region: DHH; pfam01368
632348005600	DHHA1 domain; Region: DHHA1; pfam02272
632348005601	Predicted membrane protein (DUF2232); Region: DUF2232; cl01728
632348005602	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
632348005603	Prephenate dehydratase; Region: PDT; pfam00800
632348005604	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
632348005605	putative L-Phe binding site [chemical binding]; other site
632348005606	pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865
632348005607	Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376
632348005608	TPP-binding site [chemical binding]; other site
632348005609	putative dimer interface [polypeptide binding]; other site
632348005610	pyruvate flavodoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK09622
632348005611	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
632348005612	dimer interface [polypeptide binding]; other site
632348005613	PYR/PP interface [polypeptide binding]; other site
632348005614	TPP binding site [chemical binding]; other site
632348005615	substrate binding site [chemical binding]; other site
632348005616	2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family; Region: PorD_KorD; TIGR02179
632348005617	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
632348005618	2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family; Region: PorC_KorC; TIGR02175
632348005619	pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029
632348005620	Uncharacterized conserved protein [Function unknown]; Region: COG0398
632348005621	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
632348005622	seryl-tRNA synthetase; Provisional; Region: PRK05431
632348005623	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
632348005624	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
632348005625	dimer interface [polypeptide binding]; other site
632348005626	active site
632348005627	motif 1; other site
632348005628	motif 2; other site
632348005629	motif 3; other site
632348005630	Protein of unknown function DUF45; Region: DUF45; pfam01863
632348005631	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
632348005632	active site
632348005633	NTP binding site [chemical binding]; other site
632348005634	metal binding triad [ion binding]; metal-binding site
632348005635	antibiotic binding site [chemical binding]; other site
632348005636	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
632348005637	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
632348005638	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
632348005639	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
632348005640	Probable transposase; Region: OrfB_IS605; pfam01385
632348005641	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
632348005642	Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782
632348005643	nicotinate phosphoribosyltransferase; Reviewed; Region: PRK08662
632348005644	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
632348005645	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
632348005646	Walker A/P-loop; other site
632348005647	ATP binding site [chemical binding]; other site
632348005648	Q-loop/lid; other site
632348005649	ABC transporter signature motif; other site
632348005650	Walker B; other site
632348005651	D-loop; other site
632348005652	H-loop/switch region; other site
632348005653	Cobalt transport protein; Region: CbiQ; cl00463
632348005654	PDGLE domain; Region: PDGLE; pfam13190
632348005655	ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; cl00397
632348005656	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
632348005657	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
632348005658	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
632348005659	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
632348005660	mannonate dehydratase; Provisional; Region: PRK03906
632348005661	mannonate dehydratase; Region: uxuA; TIGR00695
632348005662	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
632348005663	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
632348005664	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
632348005665	Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661
632348005666	Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648
632348005667	Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477
632348005668	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
632348005669	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632348005670	active site
632348005671	phosphorylation site [posttranslational modification]
632348005672	intermolecular recognition site; other site
632348005673	dimerization interface [polypeptide binding]; other site
632348005674	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632348005675	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
632348005676	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
632348005677	dimerization interface [polypeptide binding]; other site
632348005678	Histidine kinase; Region: His_kinase; pfam06580
632348005679	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
632348005680	ATP binding site [chemical binding]; other site
632348005681	Mg2+ binding site [ion binding]; other site
632348005682	G-X-G motif; other site
632348005683	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
632348005684	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632348005685	dimer interface [polypeptide binding]; other site
632348005686	ABC-ATPase subunit interface; other site
632348005687	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
632348005688	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632348005689	dimer interface [polypeptide binding]; other site
632348005690	conserved gate region; other site
632348005691	ABC-ATPase subunit interface; other site
632348005692	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
632348005693	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
632348005694	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
632348005695	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
632348005696	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
632348005697	histidinol-phosphate aminotransferase; Provisional; Region: PRK03158
632348005698	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
632348005699	pyridoxal 5'-phosphate binding site [chemical binding]; other site
632348005700	homodimer interface [polypeptide binding]; other site
632348005701	catalytic residue [active]
632348005702	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
632348005703	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
632348005704	prephenate dehydrogenase; Validated; Region: PRK08507
632348005705	Prephenate dehydrogenase; Region: PDH; pfam02153
632348005706	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
632348005707	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
632348005708	hinge; other site
632348005709	active site
632348005710	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
632348005711	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
632348005712	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
632348005713	L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
632348005714	N- and C-terminal domain interface [polypeptide binding]; other site
632348005715	rhamnulokinase; Region: rhamnulo_kin; TIGR02627
632348005716	active site
632348005717	putative catalytic site [active]
632348005718	metal binding site [ion binding]; metal-binding site
632348005719	ATP binding site [chemical binding]; other site
632348005720	carbohydrate binding site [chemical binding]; other site
632348005721	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
632348005722	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
632348005723	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
632348005724	active site
632348005725	metal binding site [ion binding]; metal-binding site
632348005726	homotetramer interface [polypeptide binding]; other site
632348005727	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
632348005728	active site
632348005729	dimerization interface [polypeptide binding]; other site
632348005730	ribonuclease PH; Reviewed; Region: rph; PRK00173
632348005731	Ribonuclease PH; Region: RNase_PH_bact; cd11362
632348005732	hexamer interface [polypeptide binding]; other site
632348005733	active site
632348005734	Sporulation and spore germination; Region: Germane; smart00909
632348005735	Sporulation and spore germination; Region: Germane; pfam10646
632348005736	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
632348005737	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
632348005738	Mg++ binding site [ion binding]; other site
632348005739	putative catalytic motif [active]
632348005740	substrate binding site [chemical binding]; other site
632348005741	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
632348005742	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
632348005743	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
632348005744	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
632348005745	Coenzyme A binding pocket [chemical binding]; other site
632348005746	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
632348005747	MPT binding site; other site
632348005748	trimer interface [polypeptide binding]; other site
632348005749	molybdenum cofactor biosynthesis protein MoaC/MOSC-domain-containing protein; Provisional; Region: PRK14499
632348005750	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
632348005751	trimer interface [polypeptide binding]; other site
632348005752	dimer interface [polypeptide binding]; other site
632348005753	putative active site [active]
632348005754	MOSC domain; Region: MOSC; pfam03473
632348005755	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
632348005756	Radical SAM superfamily; Region: Radical_SAM; pfam04055
632348005757	FeS/SAM binding site; other site
632348005758	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
632348005759	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
632348005760	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
632348005761	dimer interface [polypeptide binding]; other site
632348005762	putative functional site; other site
632348005763	putative MPT binding site; other site
632348005764	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
632348005765	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
632348005766	dimer interface [polypeptide binding]; other site
632348005767	putative functional site; other site
632348005768	putative MPT binding site; other site
632348005769	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
632348005770	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
632348005771	Walker A/P-loop; other site
632348005772	ATP binding site [chemical binding]; other site
632348005773	Q-loop/lid; other site
632348005774	ABC transporter signature motif; other site
632348005775	Walker B; other site
632348005776	D-loop; other site
632348005777	H-loop/switch region; other site
632348005778	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632348005779	dimer interface [polypeptide binding]; other site
632348005780	conserved gate region; other site
632348005781	putative PBP binding loops; other site
632348005782	ABC-ATPase subunit interface; other site
632348005783	ABC-type tungstate transport system, permease component [Coenzyme metabolism]; Region: TupB; COG2998
632348005784	PBP superfamily domain; Region: PBP_like_2; pfam12849
632348005785	hypothetical protein; Provisional; Region: PRK08328
632348005786	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
632348005787	ATP binding site [chemical binding]; other site
632348005788	substrate interface [chemical binding]; other site
632348005789	Ubiquitin-like proteins; Region: UBQ; cl00155
632348005790	charged pocket; other site
632348005791	hydrophobic patch; other site
632348005792	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
632348005793	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730
632348005794	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
632348005795	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
632348005796	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
632348005797	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303
632348005798	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
632348005799	hypothetical protein; Validated; Region: PRK00110
632348005800	stage V sporulation protein B; Region: spore_V_B; TIGR02900
632348005801	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
632348005802	Uncharacterized conserved protein [Function unknown]; Region: COG1739
632348005803	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
632348005804	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
632348005805	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
632348005806	active site
632348005807	Ap6A binding site [chemical binding]; other site
632348005808	nudix motif; other site
632348005809	metal binding site [ion binding]; metal-binding site
632348005810	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
632348005811	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
632348005812	HflX GTPase family; Region: HflX; cd01878
632348005813	G1 box; other site
632348005814	GTP/Mg2+ binding site [chemical binding]; other site
632348005815	Switch I region; other site
632348005816	G2 box; other site
632348005817	G3 box; other site
632348005818	Switch II region; other site
632348005819	G4 box; other site
632348005820	G5 box; other site
632348005821	elongation factor Tu; Reviewed; Region: PRK00049
632348005822	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
632348005823	G1 box; other site
632348005824	GEF interaction site [polypeptide binding]; other site
632348005825	GTP/Mg2+ binding site [chemical binding]; other site
632348005826	Switch I region; other site
632348005827	G2 box; other site
632348005828	G3 box; other site
632348005829	Switch II region; other site
632348005830	G4 box; other site
632348005831	G5 box; other site
632348005832	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
632348005833	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
632348005834	Antibiotic Binding Site [chemical binding]; other site
632348005835	elongation factor G; Reviewed; Region: PRK00007
632348005836	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
632348005837	G1 box; other site
632348005838	putative GEF interaction site [polypeptide binding]; other site
632348005839	GTP/Mg2+ binding site [chemical binding]; other site
632348005840	Switch I region; other site
632348005841	G2 box; other site
632348005842	G3 box; other site
632348005843	Switch II region; other site
632348005844	G4 box; other site
632348005845	G5 box; other site
632348005846	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
632348005847	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
632348005848	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
632348005849	30S ribosomal protein S7; Validated; Region: PRK05302
632348005850	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
632348005851	S17 interaction site [polypeptide binding]; other site
632348005852	S8 interaction site; other site
632348005853	16S rRNA interaction site [nucleotide binding]; other site
632348005854	streptomycin interaction site [chemical binding]; other site
632348005855	23S rRNA interaction site [nucleotide binding]; other site
632348005856	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
632348005857	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
632348005858	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
632348005859	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
632348005860	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
632348005861	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
632348005862	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
632348005863	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
632348005864	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
632348005865	G-loop; other site
632348005866	Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168
632348005867	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
632348005868	DNA binding site [nucleotide binding]
632348005869	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
632348005870	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
632348005871	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
632348005872	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
632348005873	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
632348005874	RPB1 interaction site [polypeptide binding]; other site
632348005875	RPB10 interaction site [polypeptide binding]; other site
632348005876	RPB11 interaction site [polypeptide binding]; other site
632348005877	RPB3 interaction site [polypeptide binding]; other site
632348005878	RPB12 interaction site [polypeptide binding]; other site
632348005879	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
632348005880	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632348005881	active site
632348005882	phosphorylation site [posttranslational modification]
632348005883	intermolecular recognition site; other site
632348005884	CheB methylesterase; Region: CheB_methylest; pfam01339
632348005885	Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175
632348005886	active site
632348005887	metal binding site [ion binding]; metal-binding site
632348005888	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
632348005889	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
632348005890	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
632348005891	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
632348005892	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
632348005893	active site
632348005894	dimer interface [polypeptide binding]; other site
632348005895	motif 1; other site
632348005896	motif 2; other site
632348005897	motif 3; other site
632348005898	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
632348005899	anticodon binding site; other site
632348005900	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
632348005901	binding surface
632348005902	TPR repeat; Region: TPR_11; pfam13414
632348005903	TPR motif; other site
632348005904	Tetratricopeptide repeat; Region: TPR_16; pfam13432
632348005905	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
632348005906	binding surface
632348005907	TPR repeat; Region: TPR_11; pfam13414
632348005908	TPR motif; other site
632348005909	TPR repeat; Region: TPR_11; pfam13414
632348005910	Divergent AAA domain; Region: AAA_4; pfam04326
632348005911	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
632348005912	CHASE4 domain; Region: CHASE4; cl01308
632348005913	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
632348005914	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
632348005915	Zn2+ binding site [ion binding]; other site
632348005916	Mg2+ binding site [ion binding]; other site
632348005917	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
632348005918	Peptidase family M23; Region: Peptidase_M23; pfam01551
632348005919	Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596
632348005920	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
632348005921	ScpA/B protein; Region: ScpA_ScpB; cl00598
632348005922	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
632348005923	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
632348005924	active site
632348005925	HIGH motif; other site
632348005926	dimer interface [polypeptide binding]; other site
632348005927	KMSKS motif; other site
632348005928	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
632348005929	Peptidase family M50; Region: Peptidase_M50; pfam02163
632348005930	active site
632348005931	putative substrate binding region [chemical binding]; other site
632348005932	diaminopimelate decarboxylase; Region: lysA; TIGR01048
632348005933	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
632348005934	active site
632348005935	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
632348005936	substrate binding site [chemical binding]; other site
632348005937	catalytic residues [active]
632348005938	dimer interface [polypeptide binding]; other site
632348005939	AMP-binding domain protein; Validated; Region: PRK08315
632348005940	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
632348005941	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
632348005942	acyl-activating enzyme (AAE) consensus motif; other site
632348005943	putative AMP binding site [chemical binding]; other site
632348005944	putative active site [active]
632348005945	putative CoA binding site [chemical binding]; other site
632348005946	sporulation sigma factor SigG; Reviewed; Region: PRK08215
632348005947	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
632348005948	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
632348005949	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
632348005950	DNA binding residues [nucleotide binding]
632348005951	sporulation sigma factor SigE; Reviewed; Region: PRK08301
632348005952	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
632348005953	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
632348005954	DNA binding residues [nucleotide binding]
632348005955	Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419
632348005956	sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854
632348005957	cell division protein FtsZ; Validated; Region: PRK09330
632348005958	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
632348005959	nucleotide binding site [chemical binding]; other site
632348005960	SulA interaction site; other site
632348005961	Protein of unknown function (DUF1290); Region: DUF1290; pfam06947
632348005962	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
632348005963	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
632348005964	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
632348005965	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
632348005966	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
632348005967	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
632348005968	hinge; other site
632348005969	active site
632348005970	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
632348005971	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
632348005972	active site
632348005973	homodimer interface [polypeptide binding]; other site
632348005974	cell division protein FtsW; Region: ftsW; TIGR02614
632348005975	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106
632348005976	Putative NAD(P)-binding; Region: NAD_binding_7; cl17660
632348005977	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
632348005978	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
632348005979	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
632348005980	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
632348005981	Mg++ binding site [ion binding]; other site
632348005982	putative catalytic motif [active]
632348005983	putative substrate binding site [chemical binding]; other site
632348005984	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
632348005985	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
632348005986	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
632348005987	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
632348005988	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
632348005989	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
632348005990	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
632348005991	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
632348005992	MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451
632348005993	stage V sporulation protein D; Region: spoVD_pbp; TIGR02214
632348005994	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
632348005995	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
632348005996	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
632348005997	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
632348005998	Cell division protein FtsL; Region: FtsL; cl11433
632348005999	MraW methylase family; Region: Methyltransf_5; pfam01795
632348006000	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
632348006001	cell division protein MraZ; Reviewed; Region: PRK00326
632348006002	MraZ protein; Region: MraZ; pfam02381
632348006003	MraZ protein; Region: MraZ; pfam02381
632348006004	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
632348006005	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
632348006006	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
632348006007	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
632348006008	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
632348006009	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
632348006010	Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780
632348006011	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
632348006012	active site
632348006013	NTP binding site [chemical binding]; other site
632348006014	metal binding triad [ion binding]; metal-binding site
632348006015	antibiotic binding site [chemical binding]; other site
632348006016	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
632348006017	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
632348006018	GatB domain; Region: GatB_Yqey; smart00845
632348006019	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
632348006020	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
632348006021	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
632348006022	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
632348006023	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
632348006024	Walker A/P-loop; other site
632348006025	ATP binding site [chemical binding]; other site
632348006026	Q-loop/lid; other site
632348006027	ABC transporter signature motif; other site
632348006028	Walker B; other site
632348006029	D-loop; other site
632348006030	H-loop/switch region; other site
632348006031	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
632348006032	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
632348006033	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
632348006034	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
632348006035	dimerization interface [polypeptide binding]; other site
632348006036	domain crossover interface; other site
632348006037	redox-dependent activation switch; other site
632348006038	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
632348006039	DNA-binding site [nucleotide binding]; DNA binding site
632348006040	RNA-binding motif; other site
632348006041	Methyltransferase domain; Region: Methyltransf_23; pfam13489
632348006042	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
632348006043	S-adenosylmethionine binding site [chemical binding]; other site
632348006044	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
632348006045	GTP-binding protein Der; Reviewed; Region: PRK00093
632348006046	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
632348006047	G1 box; other site
632348006048	GTP/Mg2+ binding site [chemical binding]; other site
632348006049	Switch I region; other site
632348006050	G2 box; other site
632348006051	Switch II region; other site
632348006052	G3 box; other site
632348006053	G4 box; other site
632348006054	G5 box; other site
632348006055	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
632348006056	G1 box; other site
632348006057	GTP/Mg2+ binding site [chemical binding]; other site
632348006058	Switch I region; other site
632348006059	G2 box; other site
632348006060	G3 box; other site
632348006061	Switch II region; other site
632348006062	G4 box; other site
632348006063	G5 box; other site
632348006064	putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279
632348006065	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
632348006066	Protein of unknown function (DUF512); Region: DUF512; pfam04459
632348006067	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
632348006068	Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410
632348006069	substrate binding pocket [chemical binding]; other site
632348006070	dimer interface [polypeptide binding]; other site
632348006071	inhibitor binding site; inhibition site
632348006072	Protein of unknown function (DUF402); Region: DUF402; pfam04167
632348006073	sporulation sigma factor SigK; Reviewed; Region: PRK05803
632348006074	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
632348006075	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
632348006076	DNA binding residues [nucleotide binding]
632348006077	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
632348006078	Peptidase family U32; Region: Peptidase_U32; pfam01136
632348006079	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
632348006080	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
632348006081	YceG-like family; Region: YceG; pfam02618
632348006082	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
632348006083	dimerization interface [polypeptide binding]; other site
632348006084	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
632348006085	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
632348006086	G1 box; other site
632348006087	putative GEF interaction site [polypeptide binding]; other site
632348006088	GTP/Mg2+ binding site [chemical binding]; other site
632348006089	Switch I region; other site
632348006090	G2 box; other site
632348006091	G3 box; other site
632348006092	Switch II region; other site
632348006093	G4 box; other site
632348006094	G5 box; other site
632348006095	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
632348006096	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
632348006097	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
632348006098	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
632348006099	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
632348006100	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632348006101	dimer interface [polypeptide binding]; other site
632348006102	conserved gate region; other site
632348006103	putative PBP binding loops; other site
632348006104	ABC-ATPase subunit interface; other site
632348006105	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
632348006106	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632348006107	putative PBP binding loops; other site
632348006108	ABC-ATPase subunit interface; other site
632348006109	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
632348006110	Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563
632348006111	active site
632348006112	catalytic site [active]
632348006113	metal binding site [ion binding]; metal-binding site
632348006114	dimer interface [polypeptide binding]; other site
632348006115	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
632348006116	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
632348006117	active site
632348006118	metal binding site [ion binding]; metal-binding site
632348006119	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
632348006120	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
632348006121	active site
632348006122	metal binding site [ion binding]; metal-binding site
632348006123	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
632348006124	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
632348006125	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
632348006126	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
632348006127	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
632348006128	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
632348006129	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
632348006130	DNA binding residues [nucleotide binding]
632348006131	DNA primase; Validated; Region: dnaG; PRK05667
632348006132	CHC2 zinc finger; Region: zf-CHC2; pfam01807
632348006133	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
632348006134	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
632348006135	active site
632348006136	metal binding site [ion binding]; metal-binding site
632348006137	interdomain interaction site; other site
632348006138	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
632348006139	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
632348006140	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
632348006141	Zn2+ binding site [ion binding]; other site
632348006142	Mg2+ binding site [ion binding]; other site
632348006143	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
632348006144	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
632348006145	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
632348006146	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
632348006147	Walker A motif; other site
632348006148	ATP binding site [chemical binding]; other site
632348006149	Walker B motif; other site
632348006150	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
632348006151	Clp protease; Region: CLP_protease; pfam00574
632348006152	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
632348006153	oligomer interface [polypeptide binding]; other site
632348006154	active site residues [active]
632348006155	trigger factor; Provisional; Region: tig; PRK01490
632348006156	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
632348006157	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
632348006158	L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407
632348006159	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578
632348006160	hexamer (dimer of trimers) interface [polypeptide binding]; other site
632348006161	substrate binding site [chemical binding]; other site
632348006162	trimer interface [polypeptide binding]; other site
632348006163	Mn binding site [ion binding]; other site
632348006164	L-rhamnose isomerase; Provisional; Region: PRK01076
632348006165	Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900
632348006166	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
632348006167	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
632348006168	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
632348006169	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
632348006170	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
632348006171	tetramer interface [polypeptide binding]; other site
632348006172	TPP-binding site [chemical binding]; other site
632348006173	heterodimer interface [polypeptide binding]; other site
632348006174	phosphorylation loop region [posttranslational modification]
632348006175	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
632348006176	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
632348006177	alpha subunit interface [polypeptide binding]; other site
632348006178	TPP binding site [chemical binding]; other site
632348006179	heterodimer interface [polypeptide binding]; other site
632348006180	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
632348006181	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
632348006182	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
632348006183	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
632348006184	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
632348006185	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
632348006186	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
632348006187	E3 interaction surface; other site
632348006188	lipoyl attachment site [posttranslational modification]; other site
632348006189	e3 binding domain; Region: E3_binding; pfam02817
632348006190	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
632348006191	lipoyl synthase; Provisional; Region: PRK05481
632348006192	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
632348006193	L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238
632348006194	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
632348006195	putative NAD(P) binding site [chemical binding]; other site
632348006196	catalytic Zn binding site [ion binding]; other site
632348006197	sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384
632348006198	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
632348006199	NAD(P) binding site [chemical binding]; other site
632348006200	active site
632348006201	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
632348006202	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
632348006203	active site
632348006204	Uncharacterized conserved protein [Function unknown]; Region: COG3347
632348006205	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007
632348006206	intersubunit interface [polypeptide binding]; other site
632348006207	active site
632348006208	Zn2+ binding site [ion binding]; other site
632348006209	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596
632348006210	intersubunit interface [polypeptide binding]; other site
632348006211	active site
632348006212	Zn2+ binding site [ion binding]; other site
632348006213	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596
632348006214	intersubunit interface [polypeptide binding]; other site
632348006215	active site
632348006216	Zn2+ binding site [ion binding]; other site
632348006217	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
632348006218	Transposase [DNA replication, recombination, and repair]; Region: COG5421
632348006219	Uncharacterized conserved protein [Function unknown]; Region: COG1615
632348006220	Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699
632348006221	Protein of unknown function (DUF964); Region: DUF964; pfam06133
632348006222	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
632348006223	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
632348006224	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
632348006225	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
632348006226	DHH family; Region: DHH; pfam01368
632348006227	DHHA1 domain; Region: DHHA1; pfam02272
632348006228	Protein of unknown function (DUF3792); Region: DUF3792; cl14821
632348006229	S-adenosylmethionine synthetase; Validated; Region: PRK05250
632348006230	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
632348006231	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
632348006232	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
632348006233	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
632348006234	putative active site [active]
632348006235	Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957
632348006236	Uncharacterized conserved protein [Function unknown]; Region: COG0432
632348006237	Domain of unknown function (DUF377); Region: DUF377; pfam04041
632348006238	Predicted glycosylase [Carbohydrate transport and metabolism]; Region: COG2152
632348006239	active site
632348006240	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
632348006241	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
632348006242	Walker A/P-loop; other site
632348006243	ATP binding site [chemical binding]; other site
632348006244	Q-loop/lid; other site
632348006245	ABC transporter signature motif; other site
632348006246	Walker B; other site
632348006247	D-loop; other site
632348006248	H-loop/switch region; other site
632348006249	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
632348006250	VanZ like family; Region: VanZ; cl01971
632348006251	acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048
632348006252	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
632348006253	PYR/PP interface [polypeptide binding]; other site
632348006254	dimer interface [polypeptide binding]; other site
632348006255	TPP binding site [chemical binding]; other site
632348006256	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
632348006257	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
632348006258	TPP-binding site [chemical binding]; other site
632348006259	dimer interface [polypeptide binding]; other site
632348006260	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
632348006261	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
632348006262	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
632348006263	homodimer interface [polypeptide binding]; other site
632348006264	substrate-cofactor binding pocket; other site
632348006265	pyridoxal 5'-phosphate binding site [chemical binding]; other site
632348006266	catalytic residue [active]
632348006267	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
632348006268	metal binding site [ion binding]; metal-binding site
632348006269	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
632348006270	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
632348006271	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
632348006272	CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989
632348006273	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
632348006274	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
632348006275	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
632348006276	dimer interface [polypeptide binding]; other site
632348006277	putative anticodon binding site; other site
632348006278	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
632348006279	motif 1; other site
632348006280	active site
632348006281	motif 2; other site
632348006282	motif 3; other site
632348006283	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
632348006284	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
632348006285	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
632348006286	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
632348006287	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
632348006288	MgtE intracellular N domain; Region: MgtE_N; pfam03448
632348006289	FOG: CBS domain [General function prediction only]; Region: COG0517
632348006290	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
632348006291	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
632348006292	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
632348006293	pyridoxal 5'-phosphate binding site [chemical binding]; other site
632348006294	catalytic residue [active]
632348006295	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
632348006296	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
632348006297	CoA binding domain; Region: CoA_binding; smart00881
632348006298	hypothetical protein; Provisional; Region: PRK08582
632348006299	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
632348006300	RNA binding site [nucleotide binding]; other site
632348006301	Septum formation initiator; Region: DivIC; cl17659
632348006302	Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; pfam09578
632348006303	YabP family; Region: YabP; cl06766
632348006304	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
632348006305	RNA binding surface [nucleotide binding]; other site
632348006306	PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516
632348006307	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
632348006308	IHF dimer interface [polypeptide binding]; other site
632348006309	IHF - DNA interface [nucleotide binding]; other site
632348006310	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
632348006311	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
632348006312	homodimer interface [polypeptide binding]; other site
632348006313	metal binding site [ion binding]; metal-binding site
632348006314	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
632348006315	homodimer interface [polypeptide binding]; other site
632348006316	active site
632348006317	putative chemical substrate binding site [chemical binding]; other site
632348006318	metal binding site [ion binding]; metal-binding site
632348006319	Stage III sporulation protein D; Region: SpoIIID; cl17560
632348006320	ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222
632348006321	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219
632348006322	FAD binding pocket [chemical binding]; other site
632348006323	FAD binding motif [chemical binding]; other site
632348006324	phosphate binding motif [ion binding]; other site
632348006325	beta-alpha-beta structure motif; other site
632348006326	NAD binding pocket [chemical binding]; other site
632348006327	Iron coordination center [ion binding]; other site
632348006328	putative oxidoreductase; Provisional; Region: PRK12831
632348006329	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
632348006330	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
632348006331	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
632348006332	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
632348006333	FtsH Extracellular; Region: FtsH_ext; pfam06480
632348006334	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
632348006335	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
632348006336	Walker A motif; other site
632348006337	ATP binding site [chemical binding]; other site
632348006338	Walker B motif; other site
632348006339	arginine finger; other site
632348006340	Peptidase family M41; Region: Peptidase_M41; pfam01434
632348006341	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
632348006342	active site
632348006343	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
632348006344	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
632348006345	Ligand Binding Site [chemical binding]; other site
632348006346	TilS substrate C-terminal domain; Region: TilS_C; smart00977
632348006347	SurA N-terminal domain; Region: SurA_N_3; cl07813
632348006348	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
632348006349	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
632348006350	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559
632348006351	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
632348006352	ATP binding site [chemical binding]; other site
632348006353	putative Mg++ binding site [ion binding]; other site
632348006354	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
632348006355	nucleotide binding region [chemical binding]; other site
632348006356	ATP-binding site [chemical binding]; other site
632348006357	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
632348006358	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
632348006359	putative active site [active]
632348006360	catalytic residue [active]
632348006361	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
632348006362	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
632348006363	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
632348006364	active site
632348006365	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
632348006366	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
632348006367	Substrate binding site; other site
632348006368	Mg++ binding site; other site
632348006369	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
632348006370	active site
632348006371	substrate binding site [chemical binding]; other site
632348006372	CoA binding site [chemical binding]; other site
632348006373	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
632348006374	catalytic motif [active]
632348006375	Zn binding site [ion binding]; other site
632348006376	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
632348006377	active site
632348006378	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
632348006379	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
632348006380	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
632348006381	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
632348006382	hinge; other site
632348006383	active site
632348006384	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
632348006385	Predicted amidohydrolase [General function prediction only]; Region: COG0388
632348006386	active site
632348006387	catalytic triad [active]
632348006388	dimer interface [polypeptide binding]; other site
632348006389	sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888
632348006390	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
632348006391	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
632348006392	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
632348006393	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
632348006394	Protein export membrane protein; Region: SecD_SecF; pfam02355
632348006395	protein-export membrane protein SecD; Region: secD; TIGR01129
632348006396	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
632348006397	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
632348006398	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
632348006399	trimer interface [polypeptide binding]; other site
632348006400	putative metal binding site [ion binding]; other site
632348006401	SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974
632348006402	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
632348006403	FeS/SAM binding site; other site
632348006404	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
632348006405	Protein of unknown function (DUF4001); Region: DUF4001; pfam13165
632348006406	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
632348006407	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
632348006408	intersubunit interface [polypeptide binding]; other site
632348006409	active site
632348006410	zinc binding site [ion binding]; other site
632348006411	Na+ binding site [ion binding]; other site
632348006412	putative hydrolase; Validated; Region: PRK09248
632348006413	Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437
632348006414	active site
632348006415	bifunctional phosphoglucose/phosphomannose isomerase; Validated; Region: PRK08674
632348006416	The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_1; cd05017
632348006417	dimer interface [polypeptide binding]; other site
632348006418	active site
632348006419	The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_2; cd05637
632348006420	dimer interface [polypeptide binding]; other site
632348006421	active site
632348006422	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
632348006423	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
632348006424	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331
632348006425	Transcriptional regulators [Transcription]; Region: MarR; COG1846
632348006426	MarR family; Region: MarR_2; pfam12802
632348006427	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
632348006428	ROK family; Region: ROK; pfam00480
632348006429	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
632348006430	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632348006431	dimer interface [polypeptide binding]; other site
632348006432	conserved gate region; other site
632348006433	putative PBP binding loops; other site
632348006434	ABC-ATPase subunit interface; other site
632348006435	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632348006436	dimer interface [polypeptide binding]; other site
632348006437	conserved gate region; other site
632348006438	putative PBP binding loops; other site
632348006439	ABC-ATPase subunit interface; other site
632348006440	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
632348006441	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
632348006442	Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231
632348006443	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
632348006444	minor groove reading motif; other site
632348006445	helix-hairpin-helix signature motif; other site
632348006446	substrate binding pocket [chemical binding]; other site
632348006447	active site
632348006448	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
632348006449	X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962
632348006450	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
632348006451	carbohydrate binding site [chemical binding]; other site
632348006452	pullulanase, type I; Region: pulA_typeI; TIGR02104
632348006453	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
632348006454	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
632348006455	Ca binding site [ion binding]; other site
632348006456	active site
632348006457	catalytic site [active]
632348006458	Domain of unknown function (DUF3372); Region: DUF3372; pfam11852
632348006459	Starch binding domain; Region: CBM_2; smart01065
632348006460	starch-binding site 2 [chemical binding]; other site
632348006461	starch-binding site 1 [chemical binding]; other site
632348006462	S-layer homology domain; Region: SLH; pfam00395
632348006463	S-layer homology domain; Region: SLH; pfam00395
632348006464	S-layer homology domain; Region: SLH; pfam00395
632348006465	Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231
632348006466	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
632348006467	sugar binding site [chemical binding]; other site
632348006468	Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672
632348006469	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
632348006470	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
632348006471	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
632348006472	Domain of unknown function (DUF3502); Region: DUF3502; pfam12010
632348006473	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
632348006474	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632348006475	dimer interface [polypeptide binding]; other site
632348006476	conserved gate region; other site
632348006477	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
632348006478	ABC-ATPase subunit interface; other site
632348006479	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
632348006480	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632348006481	dimer interface [polypeptide binding]; other site
632348006482	conserved gate region; other site
632348006483	ABC-ATPase subunit interface; other site
632348006484	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
632348006485	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
632348006486	dimerization interface [polypeptide binding]; other site
632348006487	Histidine kinase; Region: His_kinase; pfam06580
632348006488	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
632348006489	ATP binding site [chemical binding]; other site
632348006490	Mg2+ binding site [ion binding]; other site
632348006491	G-X-G motif; other site
632348006492	Response regulator receiver domain; Region: Response_reg; pfam00072
632348006493	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632348006494	active site
632348006495	phosphorylation site [posttranslational modification]
632348006496	intermolecular recognition site; other site
632348006497	dimerization interface [polypeptide binding]; other site
632348006498	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632348006499	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
632348006500	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632348006501	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
632348006502	Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011
632348006503	active site
632348006504	metal binding site [ion binding]; metal-binding site
632348006505	xylose isomerase; Provisional; Region: PRK05474
632348006506	xylose isomerase; Region: xylose_isom_A; TIGR02630
632348006507	Helix-turn-helix domain; Region: HTH_17; pfam12728
632348006508	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
632348006509	Major Facilitator Superfamily; Region: MFS_1; pfam07690
632348006510	putative substrate translocation pore; other site
632348006511	Response regulator receiver domain; Region: Response_reg; pfam00072
632348006512	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632348006513	active site
632348006514	phosphorylation site [posttranslational modification]
632348006515	intermolecular recognition site; other site
632348006516	dimerization interface [polypeptide binding]; other site
632348006517	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632348006518	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
632348006519	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632348006520	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
632348006521	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
632348006522	dimerization interface [polypeptide binding]; other site
632348006523	Histidine kinase; Region: His_kinase; pfam06580
632348006524	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
632348006525	ATP binding site [chemical binding]; other site
632348006526	Mg2+ binding site [ion binding]; other site
632348006527	G-X-G motif; other site
632348006528	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
632348006529	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
632348006530	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
632348006531	Domain of unknown function (DUF3502); Region: DUF3502; pfam12010
632348006532	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
632348006533	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632348006534	putative PBP binding loops; other site
632348006535	ABC-ATPase subunit interface; other site
632348006536	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
632348006537	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632348006538	dimer interface [polypeptide binding]; other site
632348006539	conserved gate region; other site
632348006540	ABC-ATPase subunit interface; other site
632348006541	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
632348006542	Carbohydrate binding domain (family 17/28); Region: CBM_17_28; pfam03424
632348006543	S-layer homology domain; Region: SLH; pfam00395
632348006544	S-layer homology domain; Region: SLH; pfam00395
632348006545	S-layer homology domain; Region: SLH; pfam00395
632348006546	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
632348006547	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
632348006548	dimer interface [polypeptide binding]; other site
632348006549	anticodon binding site; other site
632348006550	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
632348006551	homodimer interface [polypeptide binding]; other site
632348006552	motif 1; other site
632348006553	active site
632348006554	motif 2; other site
632348006555	GAD domain; Region: GAD; pfam02938
632348006556	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
632348006557	motif 3; other site
632348006558	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
632348006559	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
632348006560	dimer interface [polypeptide binding]; other site
632348006561	motif 1; other site
632348006562	active site
632348006563	motif 2; other site
632348006564	motif 3; other site
632348006565	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
632348006566	anticodon binding site; other site
632348006567	CrcB-like protein; Region: CRCB; pfam02537
632348006568	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
632348006569	Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683
632348006570	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
632348006571	Domain of unknown function (DUF3368); Region: DUF3368; pfam11848
632348006572	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
632348006573	Cation efflux family; Region: Cation_efflux; pfam01545
632348006574	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
632348006575	salt bridge; other site
632348006576	sequence-specific DNA binding site [nucleotide binding]; other site
632348006577	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
632348006578	active site
632348006579	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
632348006580	putative active site [active]
632348006581	heme pocket [chemical binding]; other site
632348006582	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632348006583	Response regulator receiver domain; Region: Response_reg; pfam00072
632348006584	active site
632348006585	phosphorylation site [posttranslational modification]
632348006586	intermolecular recognition site; other site
632348006587	dimerization interface [polypeptide binding]; other site
632348006588	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
632348006589	dimer interface [polypeptide binding]; other site
632348006590	putative CheW interface [polypeptide binding]; other site
632348006591	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
632348006592	putative binding surface; other site
632348006593	active site
632348006594	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
632348006595	Response regulator receiver domain; Region: Response_reg; pfam00072
632348006596	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632348006597	active site
632348006598	phosphorylation site [posttranslational modification]
632348006599	intermolecular recognition site; other site
632348006600	dimerization interface [polypeptide binding]; other site
632348006601	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
632348006602	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
632348006603	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
632348006604	S-adenosylmethionine binding site [chemical binding]; other site
632348006605	HEAT repeats; Region: HEAT_2; pfam13646
632348006606	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020
632348006607	HEAT repeats; Region: HEAT_2; pfam13646
632348006608	protein binding surface [polypeptide binding]; other site
632348006609	HEAT repeats; Region: HEAT_2; pfam13646
632348006610	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
632348006611	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
632348006612	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
632348006613	ATP binding site [chemical binding]; other site
632348006614	Mg2+ binding site [ion binding]; other site
632348006615	G-X-G motif; other site
632348006616	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
632348006617	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
632348006618	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632348006619	active site
632348006620	phosphorylation site [posttranslational modification]
632348006621	intermolecular recognition site; other site
632348006622	dimerization interface [polypeptide binding]; other site
632348006623	CheB methylesterase; Region: CheB_methylest; pfam01339
632348006624	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
632348006625	putative CheA interaction surface; other site
632348006626	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
632348006627	dimer interface [polypeptide binding]; other site
632348006628	putative CheW interface [polypeptide binding]; other site
632348006629	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
632348006630	dimer interface [polypeptide binding]; other site
632348006631	putative CheW interface [polypeptide binding]; other site
632348006632	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
632348006633	prolyl-tRNA synthetase; Provisional; Region: PRK09194
632348006634	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
632348006635	dimer interface [polypeptide binding]; other site
632348006636	motif 1; other site
632348006637	active site
632348006638	motif 2; other site
632348006639	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
632348006640	putative deacylase active site [active]
632348006641	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
632348006642	active site
632348006643	motif 3; other site
632348006644	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
632348006645	anticodon binding site; other site
632348006646	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
632348006647	Mechanosensitive ion channel; Region: MS_channel; pfam00924
632348006648	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
632348006649	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
632348006650	catalytic triad [active]
632348006651	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
632348006652	ANTAR domain; Region: ANTAR; pfam03861
632348006653	GAF domain; Region: GAF_3; pfam13492
632348006654	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
632348006655	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
632348006656	Zn2+ binding site [ion binding]; other site
632348006657	Mg2+ binding site [ion binding]; other site
632348006658	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
632348006659	N- and C-terminal domain interface [polypeptide binding]; other site
632348006660	D-xylulose kinase; Region: XylB; TIGR01312
632348006661	active site
632348006662	MgATP binding site [chemical binding]; other site
632348006663	catalytic site [active]
632348006664	metal binding site [ion binding]; metal-binding site
632348006665	xylulose binding site [chemical binding]; other site
632348006666	homodimer interface [polypeptide binding]; other site
632348006667	Transcriptional regulators [Transcription]; Region: PurR; COG1609
632348006668	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
632348006669	DNA binding site [nucleotide binding]
632348006670	domain linker motif; other site
632348006671	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
632348006672	dimerization interface [polypeptide binding]; other site
632348006673	ligand binding site [chemical binding]; other site
632348006674	Domain of unknown function (DUF4176); Region: DUF4176; cl01867
632348006675	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
632348006676	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
632348006677	catalytic motif [active]
632348006678	Zn binding site [ion binding]; other site
632348006679	RibD C-terminal domain; Region: RibD_C; cl17279
632348006680	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
632348006681	Lumazine binding domain; Region: Lum_binding; pfam00677
632348006682	Lumazine binding domain; Region: Lum_binding; pfam00677
632348006683	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
632348006684	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
632348006685	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
632348006686	dimerization interface [polypeptide binding]; other site
632348006687	active site
632348006688	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
632348006689	homopentamer interface [polypeptide binding]; other site
632348006690	active site
632348006691	HEPN domain; Region: HEPN; pfam05168
632348006692	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
632348006693	active site
632348006694	NTP binding site [chemical binding]; other site
632348006695	metal binding triad [ion binding]; metal-binding site
632348006696	antibiotic binding site [chemical binding]; other site
632348006697	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
632348006698	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
632348006699	Bacterial SH3 domain; Region: SH3_3; cl17532
632348006700	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
632348006701	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
632348006702	hypothetical protein; Reviewed; Region: PRK00024
632348006703	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
632348006704	MPN+ (JAMM) motif; other site
632348006705	Zinc-binding site [ion binding]; other site
632348006706	glycogen branching enzyme; Provisional; Region: PRK12313
632348006707	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
632348006708	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
632348006709	active site
632348006710	catalytic site [active]
632348006711	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
632348006712	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
632348006713	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
632348006714	ligand binding site; other site
632348006715	oligomer interface; other site
632348006716	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
632348006717	dimer interface [polypeptide binding]; other site
632348006718	N-terminal domain interface [polypeptide binding]; other site
632348006719	sulfate 1 binding site; other site
632348006720	glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092
632348006721	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
632348006722	ligand binding site; other site
632348006723	oligomer interface; other site
632348006724	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
632348006725	dimer interface [polypeptide binding]; other site
632348006726	N-terminal domain interface [polypeptide binding]; other site
632348006727	sulfate 1 binding site; other site
632348006728	glycogen synthase; Provisional; Region: glgA; PRK00654
632348006729	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
632348006730	ADP-binding pocket [chemical binding]; other site
632348006731	homodimer interface [polypeptide binding]; other site
632348006732	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
632348006733	homodimer interface [polypeptide binding]; other site
632348006734	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
632348006735	active site pocket [active]
632348006736	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834
632348006737	active site
632348006738	catalytic triad [active]
632348006739	oxyanion hole [active]
632348006740	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
632348006741	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
632348006742	nucleotide binding site [chemical binding]; other site
632348006743	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270
632348006744	ATP cone domain; Region: ATP-cone; pfam03477
632348006745	Class III ribonucleotide reductase; Region: RNR_III; cd01675
632348006746	effector binding site; other site
632348006747	active site
632348006748	Zn binding site [ion binding]; other site
632348006749	glycine loop; other site
632348006750	4Fe-4S binding domain; Region: Fer4_5; pfam12801
632348006751	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
632348006752	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
632348006753	aspartate aminotransferase; Provisional; Region: PRK06290
632348006754	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
632348006755	pyridoxal 5'-phosphate binding site [chemical binding]; other site
632348006756	homodimer interface [polypeptide binding]; other site
632348006757	catalytic residue [active]
632348006758	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
632348006759	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
632348006760	nucleotide binding site [chemical binding]; other site
632348006761	Type III pantothenate kinase; Region: Pan_kinase; cl17198
632348006762	spore coat protein, CotS family; Region: spore_CotS; TIGR02906
632348006763	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
632348006764	substrate binding site [chemical binding]; other site
632348006765	spore coat protein, CotS family; Region: spore_CotS; TIGR02906
632348006766	spore coat protein, CotS family; Region: spore_CotS; TIGR02906
632348006767	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
632348006768	substrate binding site [chemical binding]; other site
632348006769	Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090
632348006770	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
632348006771	ATP binding site [chemical binding]; other site
632348006772	Mg2+ binding site [ion binding]; other site
632348006773	G-X-G motif; other site
632348006774	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
632348006775	L-threonine dehydrogenase; Region: threonine_DH_like; cd08234
632348006776	putative NAD(P) binding site [chemical binding]; other site
632348006777	catalytic Zn binding site [ion binding]; other site
632348006778	Domain of unknown function (DUF377); Region: DUF377; pfam04041
632348006779	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
632348006780	active site
632348006781	Domain of unknown function (DUF348); Region: DUF348; pfam03990
632348006782	Domain of unknown function (DUF348); Region: DUF348; pfam03990
632348006783	G5 domain; Region: G5; pfam07501
632348006784	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
632348006785	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
632348006786	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
632348006787	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
632348006788	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
632348006789	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
632348006790	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
632348006791	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
632348006792	active site residue [active]
632348006793	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
632348006794	The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768
632348006795	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
632348006796	Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028
632348006797	active site
632348006798	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
632348006799	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
632348006800	metal binding site [ion binding]; metal-binding site
632348006801	active site
632348006802	I-site; other site
632348006803	cyanophycin synthetase; Region: cya_phycin_syn; TIGR02068
632348006804	ATP-grasp domain; Region: ATP-grasp_4; cl17255
632348006805	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
632348006806	Transcriptional regulators [Transcription]; Region: GntR; COG1802
632348006807	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
632348006808	DNA-binding site [nucleotide binding]; DNA binding site
632348006809	FCD domain; Region: FCD; pfam07729
632348006810	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
632348006811	isocitrate dehydrogenase; Validated; Region: PRK06451
632348006812	aconitate hydratase; Validated; Region: PRK07229
632348006813	Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585
632348006814	substrate binding site [chemical binding]; other site
632348006815	ligand binding site [chemical binding]; other site
632348006816	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
632348006817	substrate binding site [chemical binding]; other site
632348006818	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
632348006819	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
632348006820	putative ligand binding site [chemical binding]; other site
632348006821	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
632348006822	active site
632348006823	catalytic residues [active]
632348006824	metal binding site [ion binding]; metal-binding site
632348006825	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
632348006826	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632348006827	dimer interface [polypeptide binding]; other site
632348006828	conserved gate region; other site
632348006829	putative PBP binding loops; other site
632348006830	ABC-ATPase subunit interface; other site
632348006831	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
632348006832	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
632348006833	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cd00562
632348006834	Radical SAM superfamily; Region: Radical_SAM; pfam04055
632348006835	Nitrogenase_MoFe_alpha_like: Nitrogenase MoFe protein, alpha subunit_like. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  Three genetically distinct types of nitrogenase systems are known to exist: a...; Region: Nitrogenase_MoFe_alpha_like; cd01967
632348006836	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
632348006837	Nitrogenase_MoFe_beta_like: Nitrogenase MoFe protein, beta subunit_like. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen (N2) to ammonia.  This group contains the beta subunits of component 1 of the three known genetically...; Region: Nitrogenase_MoFe_beta_like; cd01965
632348006838	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
632348006839	nitrogenase alpha chain; Region: alt_nitrog_alph; TIGR01284
632348006840	Nitrogenase_MoFe_alpha_like: Nitrogenase MoFe protein, alpha subunit_like. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  Three genetically distinct types of nitrogenase systems are known to exist: a...; Region: Nitrogenase_MoFe_alpha_like; cd01967
632348006841	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
632348006842	Nitrogen regulatory protein P-II; Region: P-II; smart00938
632348006843	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
632348006844	Nitrogen regulatory protein P-II; Region: P-II; smart00938
632348006845	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
632348006846	nitrogenase iron protein; Region: nifH; TIGR01287
632348006847	Nucleotide-binding sites [chemical binding]; other site
632348006848	Walker A motif; other site
632348006849	Switch I region of nucleotide binding site; other site
632348006850	Fe4S4 binding sites [ion binding]; other site
632348006851	Switch II region of nucleotide binding site; other site
632348006852	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
632348006853	Nitrogen regulatory protein P-II; Region: P-II; smart00938
632348006854	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
632348006855	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
632348006856	Transposase; Region: DDE_Tnp_ISL3; pfam01610
632348006857	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
632348006858	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
632348006859	Clostridium kluyveri Re-citrate synthase and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_Re_CS; cd07947
632348006860	active site
632348006861	catalytic residues [active]
632348006862	metal binding site [ion binding]; metal-binding site
632348006863	RmuC family; Region: RmuC; pfam02646
632348006864	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
632348006865	DNA polymerase III, delta' subunit; Region: holB; TIGR00678
632348006866	DNA polymerase III subunit delta'; Validated; Region: PRK08485
632348006867	Protein of unknown function (DUF327); Region: DUF327; pfam03885
632348006868	Protein of unknown function (DUF970); Region: DUF970; pfam06153
632348006869	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
632348006870	Thymidylate kinase; Region: Thymidylate_kin; pfam02223
632348006871	TMP-binding site; other site
632348006872	ATP-binding site [chemical binding]; other site
632348006873	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
632348006874	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
632348006875	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
632348006876	catalytic residue [active]
632348006877	Fumarase C-terminus; Region: Fumerase_C; pfam05683
632348006878	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
632348006879	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
632348006880	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
632348006881	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
632348006882	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
632348006883	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
632348006884	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
632348006885	active site
632348006886	catalytic residues [active]
632348006887	metal binding site [ion binding]; metal-binding site
632348006888	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
632348006889	2-isopropylmalate synthase; Validated; Region: PRK00915
632348006890	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
632348006891	active site
632348006892	catalytic residues [active]
632348006893	metal binding site [ion binding]; metal-binding site
632348006894	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
632348006895	ketol-acid reductoisomerase; Provisional; Region: PRK05479
632348006896	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
632348006897	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
632348006898	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
632348006899	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
632348006900	putative valine binding site [chemical binding]; other site
632348006901	dimer interface [polypeptide binding]; other site
632348006902	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
632348006903	acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
632348006904	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
632348006905	PYR/PP interface [polypeptide binding]; other site
632348006906	dimer interface [polypeptide binding]; other site
632348006907	TPP binding site [chemical binding]; other site
632348006908	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
632348006909	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
632348006910	TPP-binding site [chemical binding]; other site
632348006911	dimer interface [polypeptide binding]; other site
632348006912	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
632348006913	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
632348006914	NAD(P) binding site [chemical binding]; other site
632348006915	active site
632348006916	Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237
632348006917	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
632348006918	active site
632348006919	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
632348006920	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
632348006921	Coenzyme A binding pocket [chemical binding]; other site
632348006922	Uncharacterized conserved protein [Function unknown]; Region: COG1633
632348006923	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
632348006924	diiron binding motif [ion binding]; other site
632348006925	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
632348006926	Aspartase; Region: Aspartase; cd01357
632348006927	active sites [active]
632348006928	tetramer interface [polypeptide binding]; other site
632348006929	[FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918
632348006930	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
632348006931	G1 box; other site
632348006932	GTP/Mg2+ binding site [chemical binding]; other site
632348006933	Switch I region; other site
632348006934	G2 box; other site
632348006935	Switch II region; other site
632348006936	G3 box; other site
632348006937	G4 box; other site
632348006938	G5 box; other site
632348006939	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2859
632348006940	Predicted acetyltransferase [General function prediction only]; Region: COG3393
632348006941	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
632348006942	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
632348006943	Melibiase; Region: Melibiase; pfam02065
632348006944	CRISPR associated protein Cas6; Region: Cas_Cas6; pfam01881
632348006945	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
632348006946	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
632348006947	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
632348006948	Walker A/P-loop; other site
632348006949	ATP binding site [chemical binding]; other site
632348006950	Q-loop/lid; other site
632348006951	ABC transporter signature motif; other site
632348006952	Walker B; other site
632348006953	D-loop; other site
632348006954	H-loop/switch region; other site
632348006955	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
632348006956	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
632348006957	active site
632348006958	catalytic tetrad [active]
632348006959	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
632348006960	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
632348006961	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
632348006962	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
632348006963	ATP binding site [chemical binding]; other site
632348006964	putative Mg++ binding site [ion binding]; other site
632348006965	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
632348006966	nucleotide binding region [chemical binding]; other site
632348006967	ATP-binding site [chemical binding]; other site
632348006968	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
632348006969	SmpB-tmRNA interface; other site
632348006970	Protein of unknown function (DUF2281); Region: DUF2281; cl02355
632348006971	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
632348006972	Bacterial sugar transferase; Region: Bac_transf; pfam02397
632348006973	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
632348006974	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
632348006975	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
632348006976	N-terminal domain of cellobiose phosphorylase (CBP) and similar proteins; Region: GH94N_CBP_like; cd11754
632348006977	catalytic domain interface [polypeptide binding]; other site
632348006978	homodimer interface [polypeptide binding]; other site
632348006979	putative active site [active]
632348006980	N-terminal domain of chitobiose phosphorylase (ChBP) and similar proteins; Region: GH94N_ChBP_like; cd11755
632348006981	catalytic domain interface [polypeptide binding]; other site
632348006982	putative homodimer interface [polypeptide binding]; other site
632348006983	Protein of unknown function, DUF608; Region: DUF608; pfam04685
632348006984	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232
632348006985	beta-galactosidase; Region: BGL; TIGR03356
632348006986	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
632348006987	Alpha amylase catalytic domain found in archaeal, bacterial, and plant Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_plant_AmyA; cd11314
632348006988	active site
632348006989	Ca binding site [ion binding]; other site
632348006990	catalytic site [active]
632348006991	Domain of unknown function (DUF1939); Region: DUF1939; pfam09154
632348006992	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
632348006993	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
632348006994	DNA binding site [nucleotide binding]
632348006995	active site
632348006996	Uncharacterized conserved protein [Function unknown]; Region: COG3339
632348006997	TRAM domain; Region: TRAM; cl01282
632348006998	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
632348006999	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
632348007000	S-adenosylmethionine binding site [chemical binding]; other site
632348007001	Hemerythrin; Region: Hemerythrin; cd12107
632348007002	Fe binding site [ion binding]; other site
632348007003	N-glycosyltransferase; Provisional; Region: PRK11204
632348007004	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
632348007005	DXD motif; other site
632348007006	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
632348007007	HEAT repeats; Region: HEAT_2; pfam13646
632348007008	HEAT repeats; Region: HEAT_2; pfam13646
632348007009	Response regulator receiver domain; Region: Response_reg; pfam00072
632348007010	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632348007011	active site
632348007012	phosphorylation site [posttranslational modification]
632348007013	intermolecular recognition site; other site
632348007014	dimerization interface [polypeptide binding]; other site
632348007015	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
632348007016	Protein of unknown function DUF58; Region: DUF58; pfam01882
632348007017	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
632348007018	pullulanase, type I; Region: pulA_typeI; TIGR02104
632348007019	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
632348007020	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
632348007021	Ca binding site [ion binding]; other site
632348007022	active site
632348007023	catalytic site [active]
632348007024	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
632348007025	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
632348007026	metal binding site [ion binding]; metal-binding site
632348007027	active site
632348007028	I-site; other site
632348007029	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
632348007030	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
632348007031	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
632348007032	Coenzyme A binding pocket [chemical binding]; other site
632348007033	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
632348007034	Glycoprotease family; Region: Peptidase_M22; pfam00814
632348007035	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
632348007036	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
632348007037	Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309
632348007038	active site
632348007039	putative GTP cyclohydrolase; Provisional; Region: PRK13674
632348007040	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
632348007041	active site
632348007042	S-layer homology domain; Region: SLH; pfam00395
632348007043	S-layer homology domain; Region: SLH; pfam00395
632348007044	Bacterial Ig-like domain; Region: Big_5; pfam13205
632348007045	RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980
632348007046	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
632348007047	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
632348007048	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
632348007049	DNA binding residues [nucleotide binding]
632348007050	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
632348007051	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
632348007052	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
632348007053	anti sigma factor interaction site; other site
632348007054	regulatory phosphorylation site [posttranslational modification]; other site
632348007055	RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2
632348007056	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
632348007057	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
632348007058	DNA binding residues [nucleotide binding]
632348007059	putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840
632348007060	dipeptidase PepV; Reviewed; Region: PRK07318
632348007061	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
632348007062	active site
632348007063	metal binding site [ion binding]; metal-binding site
632348007064	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
632348007065	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
632348007066	active site
632348007067	metal binding site [ion binding]; metal-binding site
632348007068	Uncharacterized conserved protein [Function unknown]; Region: COG0398
632348007069	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
632348007070	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
632348007071	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
632348007072	catalytic loop [active]
632348007073	iron binding site [ion binding]; other site
632348007074	Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894
632348007075	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
632348007076	Domain of unknown function DUF20; Region: UPF0118; pfam01594
632348007077	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
632348007078	Peptidase family U32; Region: Peptidase_U32; pfam01136
632348007079	Collagenase; Region: DUF3656; pfam12392
632348007080	Peptidase family U32; Region: Peptidase_U32; cl03113
632348007081	2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294
632348007082	Cell division protein ZapA; Region: ZapA; pfam05164
632348007083	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
632348007084	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
632348007085	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
632348007086	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
632348007087	active site
632348007088	catalytic tetrad [active]
632348007089	Rubrerythrin [Energy production and conversion]; Region: COG1592
632348007090	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
632348007091	binuclear metal center [ion binding]; other site
632348007092	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
632348007093	iron binding site [ion binding]; other site
632348007094	Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454
632348007095	Uncharacterized conserved protein [Function unknown]; Region: COG3461
632348007096	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
632348007097	catalytic residue [active]
632348007098	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
632348007099	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
632348007100	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
632348007101	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
632348007102	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
632348007103	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
632348007104	Transcriptional regulators [Transcription]; Region: PurR; COG1609
632348007105	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
632348007106	DNA binding site [nucleotide binding]
632348007107	domain linker motif; other site
632348007108	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
632348007109	ligand binding site [chemical binding]; other site
632348007110	dimerization interface [polypeptide binding]; other site
632348007111	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
632348007112	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632348007113	dimer interface [polypeptide binding]; other site
632348007114	conserved gate region; other site
632348007115	putative PBP binding loops; other site
632348007116	ABC-ATPase subunit interface; other site
632348007117	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
632348007118	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632348007119	putative PBP binding loops; other site
632348007120	dimer interface [polypeptide binding]; other site
632348007121	ABC-ATPase subunit interface; other site
632348007122	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
632348007123	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
632348007124	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
632348007125	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
632348007126	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
632348007127	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
632348007128	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
632348007129	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
632348007130	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
632348007131	motif II; other site
632348007132	Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; pfam09560
632348007133	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
632348007134	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
632348007135	Substrate binding site; other site
632348007136	Cupin domain; Region: Cupin_2; cl17218
632348007137	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
632348007138	active site
632348007139	substrate-binding site [chemical binding]; other site
632348007140	metal-binding site [ion binding]
632348007141	GTP binding site [chemical binding]; other site
632348007142	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
632348007143	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
632348007144	S-adenosylmethionine binding site [chemical binding]; other site
632348007145	Preprotein translocase subunit; Region: YajC; pfam02699
632348007146	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
632348007147	Radical SAM superfamily; Region: Radical_SAM; pfam04055
632348007148	FeS/SAM binding site; other site
632348007149	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
632348007150	Predicted membrane protein [Function unknown]; Region: COG2246
632348007151	GtrA-like protein; Region: GtrA; pfam04138
632348007152	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
632348007153	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
632348007154	Ligand binding site; other site
632348007155	Putative Catalytic site; other site
632348007156	DXD motif; other site
632348007157	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
632348007158	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
632348007159	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
632348007160	dimer interface [polypeptide binding]; other site
632348007161	substrate binding site [chemical binding]; other site
632348007162	ATP binding site [chemical binding]; other site
632348007163	thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190
632348007164	ThiC family; Region: ThiC; pfam01964
632348007165	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
632348007166	thiamine phosphate binding site [chemical binding]; other site
632348007167	active site
632348007168	pyrophosphate binding site [ion binding]; other site
632348007169	thiamine biosynthesis protein ThiF; Provisional; Region: PRK08644
632348007170	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196
632348007171	ATP binding site [chemical binding]; other site
632348007172	substrate interface [chemical binding]; other site
632348007173	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240
632348007174	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
632348007175	FeS/SAM binding site; other site
632348007176	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
632348007177	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
632348007178	ThiS interaction site; other site
632348007179	putative active site [active]
632348007180	tetramer interface [polypeptide binding]; other site
632348007181	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
632348007182	thiS-thiF/thiG interaction site; other site
632348007183	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
632348007184	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
632348007185	Predicted transcriptional regulators [Transcription]; Region: COG1725
632348007186	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
632348007187	DNA-binding site [nucleotide binding]; DNA binding site
632348007188	Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086
632348007189	Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679
632348007190	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
632348007191	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
632348007192	Hpr binding site; other site
632348007193	active site
632348007194	homohexamer subunit interaction site [polypeptide binding]; other site
632348007195	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
632348007196	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
632348007197	GIY-YIG motif/motif A; other site
632348007198	active site
632348007199	catalytic site [active]
632348007200	putative DNA binding site [nucleotide binding]; other site
632348007201	metal binding site [ion binding]; metal-binding site
632348007202	UvrB/uvrC motif; Region: UVR; pfam02151
632348007203	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
632348007204	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
632348007205	YbbR-like protein; Region: YbbR; pfam07949
632348007206	Uncharacterized conserved protein [Function unknown]; Region: COG1624
632348007207	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
632348007208	Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180
632348007209	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
632348007210	FeS/SAM binding site; other site
632348007211	hypothetical protein; Provisional; Region: PRK03881
632348007212	The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951
632348007213	AMMECR1; Region: AMMECR1; pfam01871
632348007214	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
632348007215	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
632348007216	DNA interaction; other site
632348007217	Metal-binding active site; metal-binding site
632348007218	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
632348007219	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
632348007220	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
632348007221	Transcriptional regulators [Transcription]; Region: PurR; COG1609
632348007222	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
632348007223	DNA binding site [nucleotide binding]
632348007224	domain linker motif; other site
632348007225	Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284
632348007226	dimerization interface [polypeptide binding]; other site
632348007227	ligand binding site [chemical binding]; other site
632348007228	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
632348007229	putative substrate translocation pore; other site
632348007230	Major Facilitator Superfamily; Region: MFS_1; pfam07690
632348007231	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495
632348007232	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
632348007233	FeS/SAM binding site; other site
632348007234	Part of AAA domain; Region: AAA_19; pfam13245
632348007235	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
632348007236	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
632348007237	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
632348007238	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
632348007239	Walker A/P-loop; other site
632348007240	ATP binding site [chemical binding]; other site
632348007241	Q-loop/lid; other site
632348007242	ABC transporter signature motif; other site
632348007243	Walker B; other site
632348007244	D-loop; other site
632348007245	H-loop/switch region; other site
632348007246	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
632348007247	putative active site [active]
632348007248	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
632348007249	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
632348007250	Walker A/P-loop; other site
632348007251	ATP binding site [chemical binding]; other site
632348007252	Q-loop/lid; other site
632348007253	ABC transporter signature motif; other site
632348007254	Walker B; other site
632348007255	D-loop; other site
632348007256	H-loop/switch region; other site
632348007257	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
632348007258	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
632348007259	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
632348007260	HlyD family secretion protein; Region: HlyD_3; pfam13437
632348007261	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
632348007262	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
632348007263	putative active site [active]
632348007264	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
632348007265	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
632348007266	Walker A/P-loop; other site
632348007267	ATP binding site [chemical binding]; other site
632348007268	Q-loop/lid; other site
632348007269	ABC transporter signature motif; other site
632348007270	Walker B; other site
632348007271	D-loop; other site
632348007272	H-loop/switch region; other site
632348007273	bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645
632348007274	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
632348007275	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
632348007276	FAD binding site [chemical binding]; other site
632348007277	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
632348007278	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
632348007279	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
632348007280	regulatory protein interface [polypeptide binding]; other site
632348007281	active site
632348007282	regulatory phosphorylation site [posttranslational modification]; other site
632348007283	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
632348007284	Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650
632348007285	Sec8 exocyst complex component specific domain; Region: Sec8_exocyst; pfam04048
632348007286	Protein of unknown function (DUF3288); Region: DUF3288; pfam11691
632348007287	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
632348007288	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
632348007289	phosphate binding site [ion binding]; other site
632348007290	putative substrate binding pocket [chemical binding]; other site
632348007291	dimer interface [polypeptide binding]; other site
632348007292	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
632348007293	shikimate kinase; Reviewed; Region: aroK; PRK00131
632348007294	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
632348007295	FAD binding domain; Region: FAD_binding_4; pfam01565
632348007296	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
632348007297	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
632348007298	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
632348007299	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
632348007300	active site
632348007301	motif I; other site
632348007302	motif II; other site
632348007303	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
632348007304	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
632348007305	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
632348007306	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
632348007307	dimerization interface [polypeptide binding]; other site
632348007308	putative DNA binding site [nucleotide binding]; other site
632348007309	putative Zn2+ binding site [ion binding]; other site
632348007310	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
632348007311	Heavy-metal-associated domain; Region: HMA; pfam00403
632348007312	metal-binding site [ion binding]
632348007313	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
632348007314	Soluble P-type ATPase [General function prediction only]; Region: COG4087
632348007315	Bifunctional nuclease; Region: DNase-RNase; pfam02577
632348007316	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
632348007317	radical SAM protein, TatD family-associated; Region: tatD_link_rSAM; TIGR04038
632348007318	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
632348007319	FeS/SAM binding site; other site
632348007320	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
632348007321	active site
632348007322	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
632348007323	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
632348007324	active site
632348007325	HIGH motif; other site
632348007326	KMSKS motif; other site
632348007327	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
632348007328	tRNA binding surface [nucleotide binding]; other site
632348007329	anticodon binding site; other site
632348007330	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
632348007331	dimer interface [polypeptide binding]; other site
632348007332	putative tRNA-binding site [nucleotide binding]; other site
632348007333	2-phosphosulfolactate phosphatase; Provisional; Region: PRK00886
632348007334	Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045
632348007335	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
632348007336	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632348007337	active site
632348007338	phosphorylation site [posttranslational modification]
632348007339	intermolecular recognition site; other site
632348007340	dimerization interface [polypeptide binding]; other site
632348007341	CheB methylesterase; Region: CheB_methylest; pfam01339
632348007342	Domain of unknown function (DUF3842); Region: DUF3842; pfam12953
632348007343	Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191
632348007344	FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663
632348007345	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; pfam01258
632348007346	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
632348007347	homodimer interaction site [polypeptide binding]; other site
632348007348	cofactor binding site; other site
632348007349	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
632348007350	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
632348007351	Walker A/P-loop; other site
632348007352	ATP binding site [chemical binding]; other site
632348007353	Q-loop/lid; other site
632348007354	ABC transporter signature motif; other site
632348007355	Walker B; other site
632348007356	D-loop; other site
632348007357	H-loop/switch region; other site
632348007358	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
632348007359	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
632348007360	dimer interface [polypeptide binding]; other site
632348007361	putative PBP binding regions; other site
632348007362	ABC-ATPase subunit  interface; other site
632348007363	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
632348007364	Metal binding protein HemV-2.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147
632348007365	putative metal binding site [ion binding]; other site
632348007366	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
632348007367	putative active site [active]
632348007368	Protein of unknown function N-terminus (DUF3323); Region: DUF3323; pfam11796
632348007369	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cd00188
632348007370	active site
632348007371	metal binding site [ion binding]; metal-binding site
632348007372	Protein of unknown function (DUF2398); Region: DUF2398; pfam09661
632348007373	Protein of unknown function (DUF2397); Region: DUF2397; pfam09660
632348007374	TIGR02677 family protein; Region: TIGR02677
632348007375	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
632348007376	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
632348007377	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
632348007378	Stage II sporulation protein; Region: SpoIID; pfam08486
632348007379	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
632348007380	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
632348007381	TrkA-N domain; Region: TrkA_N; pfam02254
632348007382	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
632348007383	TrkA-N domain; Region: TrkA_N; pfam02254
632348007384	TrkA-C domain; Region: TrkA_C; pfam02080
632348007385	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
632348007386	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
632348007387	Predicted integral membrane protein [Function unknown]; Region: COG5652
632348007388	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
632348007389	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
632348007390	ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249
632348007391	Walker A/P-loop; other site
632348007392	ATP binding site [chemical binding]; other site
632348007393	Q-loop/lid; other site
632348007394	ABC transporter signature motif; other site
632348007395	Walker B; other site
632348007396	D-loop; other site
632348007397	H-loop/switch region; other site
632348007398	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
632348007399	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
632348007400	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
632348007401	Walker A/P-loop; other site
632348007402	ATP binding site [chemical binding]; other site
632348007403	Q-loop/lid; other site
632348007404	ABC transporter signature motif; other site
632348007405	Walker B; other site
632348007406	D-loop; other site
632348007407	H-loop/switch region; other site
632348007408	Protein of unknown function (DUF2089); Region: DUF2089; pfam09862
632348007409	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
632348007410	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
632348007411	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
632348007412	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
632348007413	active site
632348007414	Substrate binding site; other site
632348007415	Mg++ binding site; other site
632348007416	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
632348007417	putative trimer interface [polypeptide binding]; other site
632348007418	putative CoA binding site [chemical binding]; other site
632348007419	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
632348007420	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
632348007421	metal binding site [ion binding]; metal-binding site
632348007422	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
632348007423	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
632348007424	chloroplast Hsp70; Provisional; Region: PLN03184
632348007425	oligosaccharide amylase; Region: oligosac_amyl; TIGR01577
632348007426	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
632348007427	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
632348007428	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
632348007429	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
632348007430	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
632348007431	NAD synthetase; Provisional; Region: PRK13981
632348007432	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
632348007433	multimer interface [polypeptide binding]; other site
632348007434	active site
632348007435	catalytic triad [active]
632348007436	protein interface 1 [polypeptide binding]; other site
632348007437	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
632348007438	homodimer interface [polypeptide binding]; other site
632348007439	NAD binding pocket [chemical binding]; other site
632348007440	ATP binding pocket [chemical binding]; other site
632348007441	Mg binding site [ion binding]; other site
632348007442	active-site loop [active]
632348007443	stage II sporulation protein D; Region: spore_II_D; TIGR02870
632348007444	Stage II sporulation protein; Region: SpoIID; pfam08486
632348007445	stage II sporulation protein E; Region: spore_II_E; TIGR02865
632348007446	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
632348007447	phage shock protein A; Region: phageshock_pspA; TIGR02977
632348007448	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
632348007449	putative active site [active]
632348007450	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
632348007451	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
632348007452	NAD(P) binding site [chemical binding]; other site
632348007453	active site
632348007454	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
632348007455	catalytic center binding site [active]
632348007456	ATP binding site [chemical binding]; other site
632348007457	Protein of unknown function (DUF3006); Region: DUF3006; pfam11213
632348007458	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
632348007459	dihydropteroate synthase; Region: DHPS; TIGR01496
632348007460	substrate binding pocket [chemical binding]; other site
632348007461	dimer interface [polypeptide binding]; other site
632348007462	inhibitor binding site; inhibition site
632348007463	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
632348007464	Biotin operon repressor [Transcription]; Region: BirA; COG1654
632348007465	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
632348007466	Protein of unknown function (DUF1284); Region: DUF1284; cl01419
632348007467	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
632348007468	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
632348007469	active site
632348007470	hinge; other site
632348007471	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
632348007472	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
632348007473	dimer interface [polypeptide binding]; other site
632348007474	putative CheW interface [polypeptide binding]; other site
632348007475	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
632348007476	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
632348007477	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
632348007478	Walker A/P-loop; other site
632348007479	ATP binding site [chemical binding]; other site
632348007480	Q-loop/lid; other site
632348007481	ABC transporter signature motif; other site
632348007482	Walker B; other site
632348007483	D-loop; other site
632348007484	H-loop/switch region; other site
632348007485	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
632348007486	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
632348007487	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
632348007488	Walker A/P-loop; other site
632348007489	ATP binding site [chemical binding]; other site
632348007490	Q-loop/lid; other site
632348007491	ABC transporter signature motif; other site
632348007492	Walker B; other site
632348007493	D-loop; other site
632348007494	H-loop/switch region; other site
632348007495	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
632348007496	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
632348007497	putative DNA binding site [nucleotide binding]; other site
632348007498	putative Zn2+ binding site [ion binding]; other site
632348007499	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, clostridial; Region: rSAM_QueE_Clost; TIGR03963
632348007500	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
632348007501	FeS/SAM binding site; other site
632348007502	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
632348007503	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
632348007504	Ligand Binding Site [chemical binding]; other site
632348007505	TIGR00269 family protein; Region: TIGR00269
632348007506	Sulfur transfer protein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ThiS; COG2104
632348007507	charged pocket; other site
632348007508	hydrophobic patch; other site
632348007509	Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly...; Region: Peptidase_C19; cl02553
632348007510	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
632348007511	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
632348007512	homotrimer interaction site [polypeptide binding]; other site
632348007513	putative active site [active]
632348007514	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
632348007515	Ligand Binding Site [chemical binding]; other site
632348007516	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
632348007517	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
632348007518	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
632348007519	G5 domain; Region: G5; pfam07501
632348007520	Peptidase family M23; Region: Peptidase_M23; pfam01551
632348007521	Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229
632348007522	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
632348007523	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
632348007524	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331
632348007525	Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229
632348007526	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
632348007527	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
632348007528	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331
632348007529	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001
632348007530	active site
632348007531	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
632348007532	Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003
632348007533	substrate binding site [chemical binding]; other site
632348007534	active site
632348007535	Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084
632348007536	metal binding site [ion binding]; metal-binding site
632348007537	ligand binding site [chemical binding]; other site
632348007538	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
632348007539	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
632348007540	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
632348007541	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632348007542	dimer interface [polypeptide binding]; other site
632348007543	conserved gate region; other site
632348007544	putative PBP binding loops; other site
632348007545	ABC-ATPase subunit interface; other site
632348007546	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
632348007547	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632348007548	ABC-ATPase subunit interface; other site
632348007549	Ubiquitin-activating enzyme e1 C-terminal domain; Region: UBA_e1_C; cl09615
632348007550	NHL repeat; Region: NHL; pfam01436
632348007551	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
632348007552	binding surface
632348007553	Tetratricopeptide repeat; Region: TPR_16; pfam13432
632348007554	TPR motif; other site
632348007555	Yip1 domain; Region: Yip1; pfam04893
632348007556	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
632348007557	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632348007558	dimer interface [polypeptide binding]; other site
632348007559	conserved gate region; other site
632348007560	putative PBP binding loops; other site
632348007561	ABC-ATPase subunit interface; other site
632348007562	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
632348007563	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
632348007564	dimer interface [polypeptide binding]; other site
632348007565	conserved gate region; other site
632348007566	putative PBP binding loops; other site
632348007567	ABC-ATPase subunit interface; other site
632348007568	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
632348007569	putative metal binding site [ion binding]; other site
632348007570	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
632348007571	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
632348007572	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
632348007573	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
632348007574	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
632348007575	Predicted methyltransferases [General function prediction only]; Region: COG0313
632348007576	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
632348007577	putative SAM binding site [chemical binding]; other site
632348007578	putative homodimer interface [polypeptide binding]; other site
632348007579	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
632348007580	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
632348007581	S-adenosylmethionine binding site [chemical binding]; other site
632348007582	Response regulator receiver domain; Region: Response_reg; pfam00072
632348007583	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632348007584	active site
632348007585	phosphorylation site [posttranslational modification]
632348007586	intermolecular recognition site; other site
632348007587	dimerization interface [polypeptide binding]; other site
632348007588	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613
632348007589	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
632348007590	FeS/SAM binding site; other site
632348007591	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
632348007592	putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959
632348007593	hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
632348007594	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
632348007595	active site
632348007596	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
632348007597	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
632348007598	DNA binding residues [nucleotide binding]
632348007599	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
632348007600	catalytic residues [active]
632348007601	catalytic nucleophile [active]
632348007602	membrane protein; Provisional; Region: PRK14404
632348007603	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
632348007604	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
632348007605	Ca binding site [ion binding]; other site
632348007606	active site
632348007607	catalytic site [active]
632348007608	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
632348007609	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
632348007610	metal binding site 2 [ion binding]; metal-binding site
632348007611	putative DNA binding helix; other site
632348007612	metal binding site 1 [ion binding]; metal-binding site
632348007613	dimer interface [polypeptide binding]; other site
632348007614	structural Zn2+ binding site [ion binding]; other site
632348007615	Rubrerythrin [Energy production and conversion]; Region: COG1592
632348007616	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
632348007617	binuclear metal center [ion binding]; other site
632348007618	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
632348007619	iron binding site [ion binding]; other site
632348007620	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
632348007621	DNA methylase; Region: N6_N4_Mtase; pfam01555
632348007622	Short C-terminal domain; Region: SHOCT; pfam09851
632348007623	Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448
632348007624	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
632348007625	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
632348007626	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
632348007627	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
632348007628	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
632348007629	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
632348007630	dimerization domain swap beta strand [polypeptide binding]; other site
632348007631	regulatory protein interface [polypeptide binding]; other site
632348007632	active site
632348007633	regulatory phosphorylation site [posttranslational modification]; other site
632348007634	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
632348007635	active site
632348007636	P-loop; other site
632348007637	phosphorylation site [posttranslational modification]
632348007638	PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427
632348007639	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
632348007640	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
632348007641	active site
632348007642	phosphorylation site [posttranslational modification]
632348007643	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
632348007644	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
632348007645	putative substrate binding site [chemical binding]; other site
632348007646	putative ATP binding site [chemical binding]; other site
632348007647	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
632348007648	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
632348007649	DNA-binding site [nucleotide binding]; DNA binding site
632348007650	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
632348007651	Alpha amylase catalytic domain found in maltosyltransferase; Region: AmyAc_MTase_N; cd11335
632348007652	homodimer interface [polypeptide binding]; other site
632348007653	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
632348007654	active site
632348007655	catalytic site [active]
632348007656	maltose binding site 2 [chemical binding]; other site
632348007657	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
632348007658	SPFH domain / Band 7 family; Region: Band_7; pfam01145
632348007659	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09679
632348007660	CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577
632348007661	CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cl12075
632348007662	CRISPR/Cas system-associated RAMP superfamily protein Cmr1; Region: Cmr1_III-B; cl17436
632348007663	CRISPR system related protein, RAMP superfamily [Defense mechanisms]; Region: COG1336
632348007664	CRISPR/Cas system-associated protein Cmr5; Region: Cmr5_III-B; cl01317
632348007665	CRISPR/Cas system-associated RAMP superfamily protein Cmr6; Region: Cmr6_III-B; cd09661
632348007666	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722
632348007667	Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930
632348007668	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
632348007669	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
632348007670	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
632348007671	CRISPR-associated protein Cas5, subtype I-B/TNEAP; Region: cas_Cas5t; TIGR01895
632348007672	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040
632348007673	CRISPR-associated negative auto-regulator DevR/Csa2; Region: DevR; pfam01905
632348007674	CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cl09909
632348007675	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652
632348007676	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
632348007677	NodB motif; other site
632348007678	putative active site [active]
632348007679	putative catalytic site [active]
632348007680	Zn binding site [ion binding]; other site
632348007681	regulatory protein SpoVG; Reviewed; Region: PRK13259
632348007682	pur operon repressor; Provisional; Region: PRK09213
632348007683	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
632348007684	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
632348007685	active site
632348007686	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
632348007687	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
632348007688	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
632348007689	Walker A/P-loop; other site
632348007690	ATP binding site [chemical binding]; other site
632348007691	Q-loop/lid; other site
632348007692	ABC transporter signature motif; other site
632348007693	Walker B; other site
632348007694	D-loop; other site
632348007695	H-loop/switch region; other site
632348007696	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
632348007697	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
632348007698	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
632348007699	Walker A/P-loop; other site
632348007700	ATP binding site [chemical binding]; other site
632348007701	Q-loop/lid; other site
632348007702	ABC transporter signature motif; other site
632348007703	Walker B; other site
632348007704	D-loop; other site
632348007705	H-loop/switch region; other site
632348007706	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
632348007707	MarR family; Region: MarR; pfam01047
632348007708	Protein of unknown function (DUF554); Region: DUF554; pfam04474
632348007709	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
632348007710	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
632348007711	Walker A/P-loop; other site
632348007712	ATP binding site [chemical binding]; other site
632348007713	Q-loop/lid; other site
632348007714	ABC transporter signature motif; other site
632348007715	Walker B; other site
632348007716	D-loop; other site
632348007717	H-loop/switch region; other site
632348007718	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
632348007719	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
632348007720	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
632348007721	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
632348007722	Histidine kinase; Region: HisKA_3; pfam07730
632348007723	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
632348007724	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
632348007725	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632348007726	active site
632348007727	phosphorylation site [posttranslational modification]
632348007728	intermolecular recognition site; other site
632348007729	dimerization interface [polypeptide binding]; other site
632348007730	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
632348007731	DNA binding residues [nucleotide binding]
632348007732	dimerization interface [polypeptide binding]; other site
632348007733	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
632348007734	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
632348007735	active site
632348007736	phosphorylation site [posttranslational modification]
632348007737	intermolecular recognition site; other site
632348007738	dimerization interface [polypeptide binding]; other site
632348007739	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
632348007740	DNA binding site [nucleotide binding]
632348007741	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
632348007742	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
632348007743	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
632348007744	ATP binding site [chemical binding]; other site
632348007745	Mg2+ binding site [ion binding]; other site
632348007746	G-X-G motif; other site
632348007747	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
632348007748	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
632348007749	Walker A/P-loop; other site
632348007750	ATP binding site [chemical binding]; other site
632348007751	Q-loop/lid; other site
632348007752	ABC transporter signature motif; other site
632348007753	Walker B; other site
632348007754	D-loop; other site
632348007755	H-loop/switch region; other site
632348007756	FtsX-like permease family; Region: FtsX; pfam02687
632348007757	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
632348007758	PIN domain; Region: PIN; pfam01850
632348007759	putative active site [active]
632348007760	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
632348007761	dimerization interface [polypeptide binding]; other site
632348007762	putative DNA binding site [nucleotide binding]; other site
632348007763	putative Zn2+ binding site [ion binding]; other site
632348007764	Predicted permeases [General function prediction only]; Region: COG0701
632348007765	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
632348007766	transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765
632348007767	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
632348007768	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
632348007769	DNA binding residues [nucleotide binding]
632348007770	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
632348007771	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
632348007772	catalytic residues [active]
632348007773	catalytic nucleophile [active]
632348007774	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
632348007775	Helix-turn-helix domain; Region: HTH_18; pfam12833
632348007776	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
632348007777	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
632348007778	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
632348007779	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
632348007780	Coenzyme A binding pocket [chemical binding]; other site
632348007781	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
632348007782	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
632348007783	putative active site [active]
632348007784	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
632348007785	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
632348007786	Major Facilitator Superfamily; Region: MFS_1; pfam07690
632348007787	putative substrate translocation pore; other site
632348007788	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
632348007789	biotin synthase; Provisional; Region: PRK07094
632348007790	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
632348007791	FeS/SAM binding site; other site
632348007792	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
632348007793	Transglycosylase; Region: Transgly; pfam00912
632348007794	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
632348007795	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
632348007796	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
632348007797	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722
632348007798	Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930
632348007799	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
632348007800	DEAD-like helicases superfamily; Region: DEXDc; smart00487
632348007801	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
632348007802	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040
632348007803	Family of unknown function (DUF694); Region: DUF694; pfam05107
632348007804	CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cd09730
632348007805	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
632348007806	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
632348007807	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
632348007808	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
632348007809	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
632348007810	nucleotide binding site [chemical binding]; other site
632348007811	putative NEF/HSP70 interaction site [polypeptide binding]; other site
632348007812	SBD interface [polypeptide binding]; other site
632348007813	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
632348007814	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
632348007815	Walker A motif; other site
632348007816	ATP binding site [chemical binding]; other site
632348007817	Walker B motif; other site
632348007818	arginine finger; other site
632348007819	CRISPR-associated (Cas) DxTHG family; Region: Cas_DxTHG; pfam09455
632348007820	CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl14784
632348007821	Domain of unknown function (DUF1848); Region: DUF1848; pfam08902
632348007822	CRISPR-associated (Cas) DxTHG family; Region: Cas_DxTHG; pfam09455
632348007823	CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl17439
632348007824	Archaeal ATPase; Region: Arch_ATPase; pfam01637
632348007825	AAA domain; Region: AAA_14; pfam13173
632348007826	Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008
632348007827	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
632348007828	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
632348007829	active site
632348007830	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
632348007831	phosphopeptide binding site; other site
632348007832	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
632348007833	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
632348007834	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
632348007835	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
632348007836	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
632348007837	Walker A motif; other site
632348007838	ATP binding site [chemical binding]; other site
632348007839	Walker B motif; other site
632348007840	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
632348007841	RIO kinase family, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside...; Region: RIO; cl17248
632348007842	ATP binding site [chemical binding]; other site
632348007843	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
632348007844	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
632348007845	active site
632348007846	ATP binding site [chemical binding]; other site
632348007847	substrate binding site [chemical binding]; other site
632348007848	activation loop (A-loop); other site
632348007849	CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cl17437
632348007850	CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cl17438
632348007851	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214
632348007852	CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cl00622
632348007853	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680
632348007854	CRISPR-associated protein Cas10/Csm1, subtype III-A/MTUBE; Region: cas_TM1811_Csm1; TIGR02578
632348007855	Archaeal ATPase; Region: Arch_ATPase; pfam01637
632348007856	AAA ATPase domain; Region: AAA_16; pfam13191
632348007857	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
632348007858	Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008
632348007859	Restriction endonuclease; Region: Mrr_cat; pfam04471
632348007860	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
632348007861	Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972
632348007862	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
632348007863	active site
632348007864	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
632348007865	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
632348007866	DNA methylase; Region: N6_N4_Mtase; pfam01555
632348007867	Domain of unknown function (DUF303); Region: DUF303; pfam03629
632348007868	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
632348007869	Domain of unknown function (DUF303); Region: DUF303; pfam03629
632348007870	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
632348007871	Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967
632348007872	putative active site [active]
632348007873	putative metal binding site [ion binding]; other site
632348007874	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495
632348007875	BioY family; Region: BioY; pfam02632
632348007876	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
632348007877	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
632348007878	DNA binding site [nucleotide binding]
632348007879	AAA domain; Region: AAA_30; pfam13604
632348007880	Family description; Region: UvrD_C_2; pfam13538
632348007881	YvrJ protein family; Region: YvrJ; pfam12841
632348007882	Protein of unknown function (DUF2922); Region: DUF2922; pfam11148
632348007883	Protein of unknown function (DUF1659); Region: DUF1659; pfam07872
632348007884	stage V sporulation protein AC; Region: spore_V_AC; TIGR02838
632348007885	stage V sporulation protein AD; Validated; Region: PRK08304
632348007886	stage V sporulation protein AD; Provisional; Region: PRK12404
632348007887	stage V sporulation protein AE; Region: spore_V_AE; TIGR02839
632348007888	Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232
632348007889	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
632348007890	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
632348007891	substrate binding pocket [chemical binding]; other site
632348007892	membrane-bound complex binding site; other site
632348007893	hinge residues; other site
632348007894	PAS domain S-box; Region: sensory_box; TIGR00229
632348007895	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
632348007896	putative active site [active]
632348007897	heme pocket [chemical binding]; other site
632348007898	PAS domain S-box; Region: sensory_box; TIGR00229
632348007899	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
632348007900	heme pocket [chemical binding]; other site
632348007901	putative active site [active]
632348007902	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
632348007903	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
632348007904	metal binding site [ion binding]; metal-binding site
632348007905	active site
632348007906	I-site; other site
632348007907	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
632348007908	WYL domain; Region: WYL; pfam13280
632348007909	WYL domain; Region: WYL; pfam13280
632348007910	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
632348007911	dimerization interface [polypeptide binding]; other site
632348007912	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
632348007913	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
632348007914	dimer interface [polypeptide binding]; other site
632348007915	putative CheW interface [polypeptide binding]; other site
632348007916	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
632348007917	fumarate hydratase; Provisional; Region: PRK06246
632348007918	Colicin V production protein; Region: Colicin_V; pfam02674
632348007919	PAS fold; Region: PAS_4; pfam08448
632348007920	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
632348007921	ParB-like nuclease domain; Region: ParB; smart00470
632348007922	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
632348007923	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
632348007924	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
632348007925	P-loop; other site
632348007926	Magnesium ion binding site [ion binding]; other site
632348007927	Bacterial Ig-like domain; Region: Big_5; pfam13205
632348007928	PBP superfamily domain; Region: PBP_like_2; cl17296
632348007929	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
632348007930	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
632348007931	dimer interface [polypeptide binding]; other site
632348007932	Alkaline phosphatase homologues; Region: alkPPc; smart00098
632348007933	active site
632348007934	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
632348007935	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
632348007936	ParB-like nuclease domain; Region: ParB; smart00470
632348007937	KorB domain; Region: KorB; pfam08535
632348007938	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
632348007939	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
632348007940	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
632348007941	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
632348007942	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
632348007943	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
632348007944	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
632348007945	trmE is a tRNA modification GTPase; Region: trmE; cd04164
632348007946	G1 box; other site
632348007947	GTP/Mg2+ binding site [chemical binding]; other site
632348007948	Switch I region; other site
632348007949	G2 box; other site
632348007950	Switch II region; other site
632348007951	G3 box; other site
632348007952	G4 box; other site
632348007953	G5 box; other site
632348007954	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
632348007955	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
632348007956	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
632348007957	G-X-X-G motif; other site
632348007958	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
632348007959	RxxxH motif; other site
632348007960	60Kd inner membrane protein; Region: 60KD_IMP; pfam02096
632348007961	Haemolytic domain; Region: Haemolytic; pfam01809
632348007962	Ribonuclease P; Region: Ribonuclease_P; cl00457
632348007963	Ribosomal protein L34; Region: Ribosomal_L34; cl00370
632348007964	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
632348007965	Spore germination protein; Region: Spore_permease; cl17796
632348007966	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
632348007967	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504