-- dump date 20140619_015553 -- class Genbank::misc_feature -- table misc_feature_note -- id note 271848000001 UNKNOWN FEATURE KEY Comment; Burkholderia thailandensis E264 is an environmental isolate and the type strain of the species. It is available from the American Type Culture Collection, Mananass, VA. 271848000002 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 271848000003 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 271848000004 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 271848000005 active site 271848000006 Int/Topo IB signature motif; other site 271848000007 catalytic residues [active] 271848000008 DNA binding site [nucleotide binding] 271848000009 Protein of unknown function (DUF2471); Region: DUF2471; pfam10616 271848000010 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 271848000011 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 271848000012 non-specific DNA binding site [nucleotide binding]; other site 271848000013 salt bridge; other site 271848000014 sequence-specific DNA binding site [nucleotide binding]; other site 271848000015 Cupin domain; Region: Cupin_2; pfam07883 271848000016 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 271848000017 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 271848000018 substrate-cofactor binding pocket; other site 271848000019 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848000020 catalytic residue [active] 271848000021 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 271848000022 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 271848000023 NAD(P) binding site [chemical binding]; other site 271848000024 Potassium-transporting ATPase A subunit; Region: KdpA; cl00903 271848000025 putative acetyltransferase; Provisional; Region: PRK03624 271848000026 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 271848000027 Coenzyme A binding pocket [chemical binding]; other site 271848000028 Uncharacterized conserved protein [Function unknown]; Region: COG2353 271848000029 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 271848000030 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 271848000031 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 271848000032 SnoaL-like domain; Region: SnoaL_2; pfam12680 271848000033 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_7; cd06910 271848000034 putative active site [active] 271848000035 Zn binding site [ion binding]; other site 271848000036 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 271848000037 tartrate dehydrogenase; Region: TTC; TIGR02089 271848000038 transcriptional activator TtdR; Provisional; Region: PRK09801 271848000039 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848000040 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 271848000041 putative effector binding pocket; other site 271848000042 putative dimerization interface [polypeptide binding]; other site 271848000043 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 271848000044 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 271848000045 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 271848000046 putative C-terminal domain interface [polypeptide binding]; other site 271848000047 putative GSH binding site (G-site) [chemical binding]; other site 271848000048 putative dimer interface [polypeptide binding]; other site 271848000049 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 271848000050 putative N-terminal domain interface [polypeptide binding]; other site 271848000051 putative dimer interface [polypeptide binding]; other site 271848000052 putative substrate binding pocket (H-site) [chemical binding]; other site 271848000053 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 271848000054 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 271848000055 nucleophile elbow; other site 271848000056 Patatin phospholipase; Region: DUF3734; pfam12536 271848000057 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK13394 271848000058 classical (c) SDRs; Region: SDR_c; cd05233 271848000059 NAD(P) binding site [chemical binding]; other site 271848000060 active site 271848000061 acetoacetate decarboxylase; Provisional; Region: PRK02265 271848000062 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 271848000063 active site 271848000064 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 271848000065 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 271848000066 FAD binding pocket [chemical binding]; other site 271848000067 FAD binding motif [chemical binding]; other site 271848000068 phosphate binding motif [ion binding]; other site 271848000069 NAD binding pocket [chemical binding]; other site 271848000070 Predicted transcriptional regulators [Transcription]; Region: COG1695 271848000071 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 271848000072 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 271848000073 Cytochrome P450; Region: p450; cl12078 271848000074 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 271848000075 Protein of unknown function (DUF692); Region: DUF692; cl01263 271848000076 B12 binding domain; Region: B12-binding; pfam02310 271848000077 B12 binding site [chemical binding]; other site 271848000078 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 271848000079 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 271848000080 FeS/SAM binding site; other site 271848000081 Methyltransferase domain; Region: Methyltransf_31; pfam13847 271848000082 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848000083 S-adenosylmethionine binding site [chemical binding]; other site 271848000084 Lysine efflux permease [General function prediction only]; Region: COG1279 271848000085 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 271848000086 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848000087 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848000088 dimerization interface [polypeptide binding]; other site 271848000089 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 271848000090 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 271848000091 ligand binding site [chemical binding]; other site 271848000092 flexible hinge region; other site 271848000093 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 271848000094 putative switch regulator; other site 271848000095 non-specific DNA interactions [nucleotide binding]; other site 271848000096 DNA binding site [nucleotide binding] 271848000097 sequence specific DNA binding site [nucleotide binding]; other site 271848000098 putative cAMP binding site [chemical binding]; other site 271848000099 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 271848000100 Ligand Binding Site [chemical binding]; other site 271848000101 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 271848000102 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 271848000103 dimer interface [polypeptide binding]; other site 271848000104 NADP binding site [chemical binding]; other site 271848000105 catalytic residues [active] 271848000106 Protein of unknown function (DUF3005); Region: DUF3005; pfam11448 271848000107 Transcriptional activator HlyU; Region: HlyU; cl02273 271848000108 serine O-acetyltransferase; Region: cysE; TIGR01172 271848000109 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 271848000110 trimer interface [polypeptide binding]; other site 271848000111 active site 271848000112 substrate binding site [chemical binding]; other site 271848000113 CoA binding site [chemical binding]; other site 271848000114 short chain dehydrogenase; Provisional; Region: PRK09134 271848000115 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848000116 NAD(P) binding site [chemical binding]; other site 271848000117 active site 271848000118 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 271848000119 GTP cyclohydrolase I; Provisional; Region: PLN03044 271848000120 active site 271848000121 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848000122 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848000123 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 271848000124 substrate binding pocket [chemical binding]; other site 271848000125 dimerization interface [polypeptide binding]; other site 271848000126 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 271848000127 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 271848000128 3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429 271848000129 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 271848000130 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 271848000131 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 271848000132 tetramer interface [polypeptide binding]; other site 271848000133 active site 271848000134 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 271848000135 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 271848000136 benzoate transport; Region: 2A0115; TIGR00895 271848000137 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848000138 putative substrate translocation pore; other site 271848000139 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848000140 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 271848000141 thioredoxin 2; Provisional; Region: PRK10996 271848000142 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 271848000143 catalytic residues [active] 271848000144 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 271848000145 Outer membrane efflux protein; Region: OEP; pfam02321 271848000146 Outer membrane efflux protein; Region: OEP; pfam02321 271848000147 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 271848000148 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 271848000149 Protein export membrane protein; Region: SecD_SecF; cl14618 271848000150 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 271848000151 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 271848000152 carboxyltransferase (CT) interaction site; other site 271848000153 biotinylation site [posttranslational modification]; other site 271848000154 HlyD family secretion protein; Region: HlyD_3; pfam13437 271848000155 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 271848000156 dimerization interface [polypeptide binding]; other site 271848000157 putative DNA binding site [nucleotide binding]; other site 271848000158 putative Zn2+ binding site [ion binding]; other site 271848000159 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 271848000160 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 271848000161 Walker A/P-loop; other site 271848000162 ATP binding site [chemical binding]; other site 271848000163 Q-loop/lid; other site 271848000164 ABC transporter signature motif; other site 271848000165 Walker B; other site 271848000166 D-loop; other site 271848000167 H-loop/switch region; other site 271848000168 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 271848000169 FtsX-like permease family; Region: FtsX; pfam02687 271848000170 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 271848000171 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 271848000172 HlyD family secretion protein; Region: HlyD_3; pfam13437 271848000173 CreA protein; Region: CreA; pfam05981 271848000174 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 271848000175 cheY-homologous receiver domain; Region: REC; smart00448 271848000176 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 271848000177 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 271848000178 Cation efflux family; Region: Cation_efflux; pfam01545 271848000179 haemagglutination activity domain; Region: Haemagg_act; cl05436 271848000180 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 271848000181 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 271848000182 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 271848000183 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 271848000184 Chromate transporter; Region: Chromate_transp; pfam02417 271848000185 Chromate resistance exported protein; Region: Chrome_Resist; pfam09828 271848000186 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 271848000187 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 271848000188 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 271848000189 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 271848000190 Walker A/P-loop; other site 271848000191 ATP binding site [chemical binding]; other site 271848000192 Q-loop/lid; other site 271848000193 ABC transporter signature motif; other site 271848000194 Walker B; other site 271848000195 D-loop; other site 271848000196 H-loop/switch region; other site 271848000197 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 271848000198 Walker A/P-loop; other site 271848000199 ATP binding site [chemical binding]; other site 271848000200 Q-loop/lid; other site 271848000201 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 271848000202 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 271848000203 Walker A/P-loop; other site 271848000204 ATP binding site [chemical binding]; other site 271848000205 Q-loop/lid; other site 271848000206 ABC transporter signature motif; other site 271848000207 Walker B; other site 271848000208 D-loop; other site 271848000209 H-loop/switch region; other site 271848000210 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 271848000211 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 271848000212 Phosphoesterase family; Region: Phosphoesterase; pfam04185 271848000213 Domain of unknown function (DUF756); Region: DUF756; pfam05506 271848000214 Domain of unknown function (DUF756); Region: DUF756; pfam05506 271848000215 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 271848000216 DNA-binding interface [nucleotide binding]; DNA binding site 271848000217 RNA polymerase sigma factor; Reviewed; Region: PRK12527 271848000218 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 271848000219 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 271848000220 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 271848000221 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 271848000222 Coenzyme A binding pocket [chemical binding]; other site 271848000223 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848000224 dimer interface [polypeptide binding]; other site 271848000225 conserved gate region; other site 271848000226 putative PBP binding loops; other site 271848000227 ABC-ATPase subunit interface; other site 271848000228 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 271848000229 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848000230 dimer interface [polypeptide binding]; other site 271848000231 conserved gate region; other site 271848000232 putative PBP binding loops; other site 271848000233 ABC-ATPase subunit interface; other site 271848000234 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 271848000235 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 271848000236 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 271848000237 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 271848000238 H-NS histone family; Region: Histone_HNS; pfam00816 271848000239 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 271848000240 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 271848000241 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 271848000242 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 271848000243 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 271848000244 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253 271848000245 Protein of unknown function (DUF3274); Region: DUF3274; pfam11678 271848000246 Protein of unknown function (DUF2875); Region: DUF2875; pfam11394 271848000247 Uncharacterized conserved protein [Function unknown]; Region: COG4104 271848000248 Integrase core domain; Region: rve; pfam00665 271848000249 Protein of unknown function (DUF3274); Region: DUF3274; pfam11678 271848000250 Transposase; Region: HTH_Tnp_1; cl17663 271848000251 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 271848000252 IS2 transposase TnpB; Reviewed; Region: PRK09409 271848000253 HTH-like domain; Region: HTH_21; pfam13276 271848000254 Integrase core domain; Region: rve; pfam00665 271848000255 Integrase core domain; Region: rve_3; pfam13683 271848000256 Protein of unknown function (DUF2875); Region: DUF2875; pfam11394 271848000257 PAAR motif; Region: PAAR_motif; pfam05488 271848000258 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 271848000259 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 271848000260 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 271848000261 catalytic residues [active] 271848000262 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 271848000263 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 271848000264 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 271848000265 trimer interface [polypeptide binding]; other site 271848000266 eyelet of channel; other site 271848000267 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848000268 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848000269 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 271848000270 putative effector binding pocket; other site 271848000271 dimerization interface [polypeptide binding]; other site 271848000272 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 271848000273 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848000274 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425 271848000275 dimerization interface [polypeptide binding]; other site 271848000276 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 271848000277 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 271848000278 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 271848000279 HlyD family secretion protein; Region: HlyD_3; pfam13437 271848000280 Fusaric acid resistance protein family; Region: FUSC; pfam04632 271848000281 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 271848000282 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 271848000283 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 271848000284 trimer interface [polypeptide binding]; other site 271848000285 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 271848000286 trimer interface [polypeptide binding]; other site 271848000287 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 271848000288 trimer interface [polypeptide binding]; other site 271848000289 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 271848000290 trimer interface [polypeptide binding]; other site 271848000291 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 271848000292 trimer interface [polypeptide binding]; other site 271848000293 YadA-like C-terminal region; Region: YadA; pfam03895 271848000294 PhoPQ-activated pathogenicity-related protein; Region: PhoPQ_related; cl01750 271848000295 YfaZ precursor; Region: YfaZ; pfam07437 271848000296 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 271848000297 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 271848000298 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 271848000299 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 271848000300 PapC N-terminal domain; Region: PapC_N; pfam13954 271848000301 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 271848000302 PapC C-terminal domain; Region: PapC_C; pfam13953 271848000303 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 271848000304 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 271848000305 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 271848000306 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 271848000307 ligand binding site [chemical binding]; other site 271848000308 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 271848000309 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 271848000310 Protein of unknown function (DUF877); Region: DUF877; pfam05943 271848000311 Protein of unknown function (DUF796); Region: DUF796; pfam05638 271848000312 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 271848000313 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 271848000314 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 271848000315 hypothetical protein; Provisional; Region: PRK08126 271848000316 type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349 271848000317 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 271848000318 ligand binding site [chemical binding]; other site 271848000319 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 271848000320 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 271848000321 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 271848000322 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 271848000323 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 271848000324 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 271848000325 PAAR motif; Region: PAAR_motif; pfam05488 271848000326 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 271848000327 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 271848000328 RHS Repeat; Region: RHS_repeat; cl11982 271848000329 RHS protein; Region: RHS; pfam03527 271848000330 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 271848000331 Glycosyltransferase (GlcNAc); Region: GlcNAc; pfam11397 271848000332 Fimbrial protein; Region: Fimbrial; pfam00419 271848000333 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 271848000334 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 271848000335 type VI secretion protein, VC_A0111 family; Region: VI_chp_1; TIGR03347 271848000336 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 271848000337 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 271848000338 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 271848000339 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 271848000340 ImpE protein; Region: ImpE; pfam07024 271848000341 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 271848000342 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848000343 Walker A motif; other site 271848000344 ATP binding site [chemical binding]; other site 271848000345 Walker B motif; other site 271848000346 arginine finger; other site 271848000347 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848000348 Walker A motif; other site 271848000349 ATP binding site [chemical binding]; other site 271848000350 Walker B motif; other site 271848000351 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 271848000352 Cache domain; Region: Cache_1; pfam02743 271848000353 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 271848000354 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271848000355 dimer interface [polypeptide binding]; other site 271848000356 phosphorylation site [posttranslational modification] 271848000357 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848000358 ATP binding site [chemical binding]; other site 271848000359 Mg2+ binding site [ion binding]; other site 271848000360 G-X-G motif; other site 271848000361 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 271848000362 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848000363 active site 271848000364 phosphorylation site [posttranslational modification] 271848000365 intermolecular recognition site; other site 271848000366 dimerization interface [polypeptide binding]; other site 271848000367 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 271848000368 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848000369 active site 271848000370 phosphorylation site [posttranslational modification] 271848000371 intermolecular recognition site; other site 271848000372 dimerization interface [polypeptide binding]; other site 271848000373 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 271848000374 DNA binding residues [nucleotide binding] 271848000375 dimerization interface [polypeptide binding]; other site 271848000376 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 271848000377 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848000378 active site 271848000379 phosphorylation site [posttranslational modification] 271848000380 intermolecular recognition site; other site 271848000381 dimerization interface [polypeptide binding]; other site 271848000382 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 271848000383 DNA binding residues [nucleotide binding] 271848000384 dimerization interface [polypeptide binding]; other site 271848000385 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 271848000386 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 271848000387 substrate binding pocket [chemical binding]; other site 271848000388 membrane-bound complex binding site; other site 271848000389 hinge residues; other site 271848000390 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 271848000391 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271848000392 dimer interface [polypeptide binding]; other site 271848000393 phosphorylation site [posttranslational modification] 271848000394 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848000395 ATP binding site [chemical binding]; other site 271848000396 Mg2+ binding site [ion binding]; other site 271848000397 G-X-G motif; other site 271848000398 Response regulator receiver domain; Region: Response_reg; pfam00072 271848000399 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848000400 active site 271848000401 phosphorylation site [posttranslational modification] 271848000402 intermolecular recognition site; other site 271848000403 dimerization interface [polypeptide binding]; other site 271848000404 FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198 271848000405 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 271848000406 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 271848000407 active site 271848000408 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848000409 S-adenosylmethionine binding site [chemical binding]; other site 271848000410 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 271848000411 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 271848000412 Soluble P-type ATPase [General function prediction only]; Region: COG4087 271848000413 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 271848000414 active site 271848000415 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 271848000416 flagellin; Provisional; Region: PRK12802 271848000417 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 271848000418 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 271848000419 flagellar motor protein MotA; Provisional; Region: PRK12482 271848000420 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 271848000421 hypothetical protein; Validated; Region: PRK06778 271848000422 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 271848000423 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 271848000424 ligand binding site [chemical binding]; other site 271848000425 Response regulator receiver domain; Region: Response_reg; pfam00072 271848000426 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848000427 active site 271848000428 phosphorylation site [posttranslational modification] 271848000429 intermolecular recognition site; other site 271848000430 dimerization interface [polypeptide binding]; other site 271848000431 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 271848000432 putative binding surface; other site 271848000433 active site 271848000434 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 271848000435 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848000436 ATP binding site [chemical binding]; other site 271848000437 Mg2+ binding site [ion binding]; other site 271848000438 G-X-G motif; other site 271848000439 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 271848000440 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 271848000441 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 271848000442 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 271848000443 dimer interface [polypeptide binding]; other site 271848000444 putative CheW interface [polypeptide binding]; other site 271848000445 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 271848000446 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 271848000447 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848000448 CheD chemotactic sensory transduction; Region: CheD; cl00810 271848000449 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 271848000450 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848000451 active site 271848000452 phosphorylation site [posttranslational modification] 271848000453 intermolecular recognition site; other site 271848000454 dimerization interface [polypeptide binding]; other site 271848000455 CheB methylesterase; Region: CheB_methylest; pfam01339 271848000456 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 271848000457 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848000458 active site 271848000459 phosphorylation site [posttranslational modification] 271848000460 intermolecular recognition site; other site 271848000461 dimerization interface [polypeptide binding]; other site 271848000462 CheB methylesterase; Region: CheB_methylest; pfam01339 271848000463 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 271848000464 FHIPEP family; Region: FHIPEP; pfam00771 271848000465 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 271848000466 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 271848000467 Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684 271848000468 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 271848000469 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 271848000470 flagellar motor switch protein FliN; Region: fliN; TIGR02480 271848000471 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 271848000472 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 271848000473 flagellar MS-ring protein; Reviewed; Region: fliF; PRK07193 271848000474 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 271848000475 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 271848000476 flagellar motor switch protein G; Reviewed; Region: fliG; PRK07194 271848000477 FliG C-terminal domain; Region: FliG_C; pfam01706 271848000478 flagellar assembly protein H; Provisional; Region: fliH; PRK13386 271848000479 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 271848000480 Flagellar assembly protein FliH; Region: FliH; pfam02108 271848000481 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07196 271848000482 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 271848000483 Walker A motif; other site 271848000484 ATP binding site [chemical binding]; other site 271848000485 Walker B motif; other site 271848000486 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 271848000487 flagellar capping protein; Reviewed; Region: fliD; PRK08032 271848000488 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 271848000489 Flagellar protein FliS; Region: FliS; cl00654 271848000490 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 271848000491 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 271848000492 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 271848000493 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 271848000494 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 271848000495 DNA binding residues [nucleotide binding] 271848000496 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 271848000497 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 271848000498 SAF-like; Region: SAF_2; pfam13144 271848000499 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 271848000500 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 271848000501 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 271848000502 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK12685 271848000503 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK06802 271848000504 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 271848000505 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 271848000506 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 271848000507 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 271848000508 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 271848000509 flagellar hook protein FlgE; Validated; Region: flgE; PRK06803 271848000510 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 271848000511 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 271848000512 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 271848000513 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 271848000514 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 271848000515 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12694 271848000516 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 271848000517 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 271848000518 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698 271848000519 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 271848000520 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 271848000521 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 271848000522 Rod binding protein; Region: Rod-binding; cl01626 271848000523 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07191 271848000524 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 271848000525 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK07192 271848000526 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 271848000527 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 271848000528 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 271848000529 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848000530 active site 271848000531 phosphorylation site [posttranslational modification] 271848000532 intermolecular recognition site; other site 271848000533 dimerization interface [polypeptide binding]; other site 271848000534 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 271848000535 DNA binding residues [nucleotide binding] 271848000536 dimerization interface [polypeptide binding]; other site 271848000537 H-NS histone family; Region: Histone_HNS; pfam00816 271848000538 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 271848000539 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 271848000540 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848000541 putative substrate translocation pore; other site 271848000542 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 271848000543 pyruvate kinase; Provisional; Region: PRK06247 271848000544 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 271848000545 domain interfaces; other site 271848000546 active site 271848000547 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 271848000548 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 271848000549 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 271848000550 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 271848000551 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 271848000552 acyl-activating enzyme (AAE) consensus motif; other site 271848000553 AMP binding site [chemical binding]; other site 271848000554 active site 271848000555 CoA binding site [chemical binding]; other site 271848000556 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 271848000557 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 271848000558 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 271848000559 extended (e) SDRs; Region: SDR_e; cd08946 271848000560 NAD(P) binding site [chemical binding]; other site 271848000561 active site 271848000562 substrate binding site [chemical binding]; other site 271848000563 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848000564 active site 271848000565 SnoaL-like domain; Region: SnoaL_2; pfam12680 271848000566 O-methyltransferase; Region: Methyltransf_2; pfam00891 271848000567 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 271848000568 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271848000569 metal binding site [ion binding]; metal-binding site 271848000570 active site 271848000571 I-site; other site 271848000572 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 271848000573 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 271848000574 putative ligand binding site [chemical binding]; other site 271848000575 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 271848000576 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 271848000577 TM-ABC transporter signature motif; other site 271848000578 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 271848000579 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 271848000580 Walker A/P-loop; other site 271848000581 ATP binding site [chemical binding]; other site 271848000582 Q-loop/lid; other site 271848000583 ABC transporter signature motif; other site 271848000584 Walker B; other site 271848000585 D-loop; other site 271848000586 H-loop/switch region; other site 271848000587 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 271848000588 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 271848000589 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 271848000590 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 271848000591 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430 271848000592 Domain interface; other site 271848000593 glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535 271848000594 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 271848000595 Alpha-amylase, C-terminal CBM20 (carbohydrate-binding module, family 20) domain. This domain is found in several bacterial and fungal alpha-amylases including the maltopentaose-forming amylases (G5-amylases). Most alpha-amylases have, in addition to the...; Region: CBM20_alpha_amylase; cd05808 271848000596 starch-binding site 2 [chemical binding]; other site 271848000597 starch-binding site 1 [chemical binding]; other site 271848000598 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 271848000599 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 271848000600 ATP binding site [chemical binding]; other site 271848000601 Mg++ binding site [ion binding]; other site 271848000602 motif III; other site 271848000603 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 271848000604 nucleotide binding region [chemical binding]; other site 271848000605 ATP-binding site [chemical binding]; other site 271848000606 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 271848000607 putative RNA binding site [nucleotide binding]; other site 271848000608 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 271848000609 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 271848000610 trimer interface [polypeptide binding]; other site 271848000611 eyelet of channel; other site 271848000612 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848000613 metabolite-proton symporter; Region: 2A0106; TIGR00883 271848000614 putative substrate translocation pore; other site 271848000615 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 271848000616 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 271848000617 metal binding site [ion binding]; metal-binding site 271848000618 putative dimer interface [polypeptide binding]; other site 271848000619 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 271848000620 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848000621 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848000622 dimerization interface [polypeptide binding]; other site 271848000623 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 271848000624 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 271848000625 Fatty acid desaturase protein family subgroup, a delta-12 acyl-lipid desaturase-like, DesA-like, yet uncharacterized subgroup of membrane fatty acid desaturase proteins found in alpha-, beta-, and gamma-proteobacteria. Sequences of this domain family...; Region: DesA_FADS-like; cd03509 271848000626 putative di-iron ligands [ion binding]; other site 271848000627 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 271848000628 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 271848000629 substrate binding pocket [chemical binding]; other site 271848000630 membrane-bound complex binding site; other site 271848000631 hinge residues; other site 271848000632 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 271848000633 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 271848000634 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848000635 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848000636 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848000637 dimerization interface [polypeptide binding]; other site 271848000638 short chain dehydrogenase; Provisional; Region: PRK07023 271848000639 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848000640 NAD(P) binding site [chemical binding]; other site 271848000641 active site 271848000642 SnoaL-like domain; Region: SnoaL_2; pfam12680 271848000643 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 271848000644 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 271848000645 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 271848000646 Pyoverdine/dityrosine biosynthesis protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: DIT1; COG3207 271848000647 Pyoverdine/dityrosine biosynthesis protein; Region: DIT1_PvcA; pfam05141 271848000648 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 271848000649 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 271848000650 substrate binding pocket [chemical binding]; other site 271848000651 active site 271848000652 iron coordination sites [ion binding]; other site 271848000653 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 271848000654 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 271848000655 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 271848000656 active site 271848000657 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 271848000658 dimer interface [polypeptide binding]; other site 271848000659 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 271848000660 Ligand Binding Site [chemical binding]; other site 271848000661 Molecular Tunnel; other site 271848000662 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 271848000663 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 271848000664 NADP binding site [chemical binding]; other site 271848000665 dimer interface [polypeptide binding]; other site 271848000666 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 271848000667 active site 271848000668 metal binding site [ion binding]; metal-binding site 271848000669 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848000670 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848000671 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 271848000672 putative effector binding pocket; other site 271848000673 dimerization interface [polypeptide binding]; other site 271848000674 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 271848000675 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 271848000676 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 271848000677 tetramer interface [polypeptide binding]; other site 271848000678 TPP-binding site [chemical binding]; other site 271848000679 heterodimer interface [polypeptide binding]; other site 271848000680 phosphorylation loop region [posttranslational modification] 271848000681 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 271848000682 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 271848000683 alpha subunit interface [polypeptide binding]; other site 271848000684 TPP binding site [chemical binding]; other site 271848000685 heterodimer interface [polypeptide binding]; other site 271848000686 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 271848000687 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 271848000688 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 271848000689 E3 interaction surface; other site 271848000690 lipoyl attachment site [posttranslational modification]; other site 271848000691 e3 binding domain; Region: E3_binding; pfam02817 271848000692 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 271848000693 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 271848000694 phosphate binding site [ion binding]; other site 271848000695 metabolite-proton symporter; Region: 2A0106; TIGR00883 271848000696 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848000697 putative substrate translocation pore; other site 271848000698 Isochorismatase family; Region: Isochorismatase; pfam00857 271848000699 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 271848000700 catalytic triad [active] 271848000701 dimer interface [polypeptide binding]; other site 271848000702 conserved cis-peptide bond; other site 271848000703 LysR family transcriptional regulator; Provisional; Region: PRK14997 271848000704 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848000705 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 271848000706 putative effector binding pocket; other site 271848000707 putative dimerization interface [polypeptide binding]; other site 271848000708 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 271848000709 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848000710 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848000711 dimerization interface [polypeptide binding]; other site 271848000712 D-serine dehydratase; Provisional; Region: PRK02991 271848000713 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 271848000714 catalytic residue [active] 271848000715 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 271848000716 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848000717 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 271848000718 dimerization interface [polypeptide binding]; other site 271848000719 substrate binding pocket [chemical binding]; other site 271848000720 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848000721 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 271848000722 NAD(P) binding site [chemical binding]; other site 271848000723 active site 271848000724 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 271848000725 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 271848000726 phosphopeptide binding site; other site 271848000727 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 271848000728 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 271848000729 binding surface 271848000730 TPR motif; other site 271848000731 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 271848000732 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 271848000733 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 271848000734 hypothetical protein; Provisional; Region: PRK07033 271848000735 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 271848000736 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 271848000737 ligand binding site [chemical binding]; other site 271848000738 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 271848000739 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 271848000740 G1 box; other site 271848000741 GTP/Mg2+ binding site [chemical binding]; other site 271848000742 G2 box; other site 271848000743 G3 box; other site 271848000744 Switch II region; other site 271848000745 G4 box; other site 271848000746 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 271848000747 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 271848000748 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867 271848000749 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 271848000750 Catalytic domain of Protein Kinases; Region: PKc; cd00180 271848000751 active site 271848000752 ATP binding site [chemical binding]; other site 271848000753 substrate binding site [chemical binding]; other site 271848000754 activation loop (A-loop); other site 271848000755 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 271848000756 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 271848000757 Protein of unknown function (DUF770); Region: DUF770; pfam05591 271848000758 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 271848000759 Protein of unknown function (DUF877); Region: DUF877; pfam05943 271848000760 Protein of unknown function (DUF796); Region: DUF796; pfam05638 271848000761 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 271848000762 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 271848000763 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 271848000764 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 271848000765 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 271848000766 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848000767 Walker A motif; other site 271848000768 ATP binding site [chemical binding]; other site 271848000769 Walker B motif; other site 271848000770 arginine finger; other site 271848000771 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848000772 Walker A motif; other site 271848000773 ATP binding site [chemical binding]; other site 271848000774 Walker B motif; other site 271848000775 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 271848000776 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 271848000777 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 271848000778 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 271848000779 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 271848000780 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 271848000781 RHS Repeat; Region: RHS_repeat; pfam05593 271848000782 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 271848000783 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 271848000784 RHS Repeat; Region: RHS_repeat; pfam05593 271848000785 RHS Repeat; Region: RHS_repeat; pfam05593 271848000786 RHS Repeat; Region: RHS_repeat; pfam05593 271848000787 RHS Repeat; Region: RHS_repeat; cl11982 271848000788 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 271848000789 RHS Repeat; Region: RHS_repeat; cl11982 271848000790 RHS protein; Region: RHS; pfam03527 271848000791 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 271848000792 Xanthomonas XOO_2897-like deaminase; Region: XOO_2897-deam; pfam14440 271848000793 Transposase, Mutator family; Region: Transposase_mut; pfam00872 271848000794 Transposase, Mutator family; Region: Transposase_mut; pfam00872 271848000795 Transposase, Mutator family; Region: Transposase_mut; pfam00872 271848000796 MULE transposase domain; Region: MULE; pfam10551 271848000797 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 271848000798 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 271848000799 motif II; other site 271848000800 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 271848000801 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 271848000802 dimer interface [polypeptide binding]; other site 271848000803 ADP-ribose binding site [chemical binding]; other site 271848000804 active site 271848000805 nudix motif; other site 271848000806 metal binding site [ion binding]; metal-binding site 271848000807 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 271848000808 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 271848000809 CoenzymeA binding site [chemical binding]; other site 271848000810 subunit interaction site [polypeptide binding]; other site 271848000811 PHB binding site; other site 271848000812 acyl-CoA synthetase; Validated; Region: PRK05850 271848000813 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 271848000814 acyl-activating enzyme (AAE) consensus motif; other site 271848000815 active site 271848000816 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 271848000817 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 271848000818 active site 271848000819 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 271848000820 Fatty acid desaturase; Region: FA_desaturase; pfam00487 271848000821 Di-iron ligands [ion binding]; other site 271848000822 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 271848000823 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 271848000824 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848000825 S-adenosylmethionine binding site [chemical binding]; other site 271848000826 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 271848000827 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 271848000828 Fatty acid desaturase; Region: FA_desaturase; pfam00487 271848000829 Di-iron ligands [ion binding]; other site 271848000830 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 271848000831 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 271848000832 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 271848000833 conserved cys residue [active] 271848000834 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848000835 Isochorismatase family; Region: Isochorismatase; pfam00857 271848000836 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 271848000837 catalytic triad [active] 271848000838 conserved cis-peptide bond; other site 271848000839 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 271848000840 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 271848000841 acyl-activating enzyme (AAE) consensus motif; other site 271848000842 AMP binding site [chemical binding]; other site 271848000843 active site 271848000844 CoA binding site [chemical binding]; other site 271848000845 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 271848000846 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 271848000847 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 271848000848 ATP-grasp domain; Region: ATP-grasp_4; cl17255 271848000849 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 271848000850 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 271848000851 carboxyltransferase (CT) interaction site; other site 271848000852 biotinylation site [posttranslational modification]; other site 271848000853 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 271848000854 enoyl-CoA hydratase; Provisional; Region: PRK07468 271848000855 substrate binding site [chemical binding]; other site 271848000856 oxyanion hole (OAH) forming residues; other site 271848000857 trimer interface [polypeptide binding]; other site 271848000858 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 271848000859 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 271848000860 active site 271848000861 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 271848000862 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 271848000863 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 271848000864 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 271848000865 NAD(P) binding site [chemical binding]; other site 271848000866 substrate binding site [chemical binding]; other site 271848000867 homotetramer interface [polypeptide binding]; other site 271848000868 active site 271848000869 homodimer interface [polypeptide binding]; other site 271848000870 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 271848000871 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 271848000872 active site 271848000873 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 271848000874 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 271848000875 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 271848000876 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848000877 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848000878 Major Facilitator Superfamily; Region: MFS_1; pfam07690 271848000879 putative substrate translocation pore; other site 271848000880 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848000881 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 271848000882 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 271848000883 ATP binding site [chemical binding]; other site 271848000884 substrate interface [chemical binding]; other site 271848000885 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 271848000886 active site residue [active] 271848000887 Esterase PHB depolymerase; Region: Esterase_phd; pfam10503 271848000888 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 271848000889 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 271848000890 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 271848000891 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 271848000892 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 271848000893 catalytic triad [active] 271848000894 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848000895 S-adenosylmethionine binding site [chemical binding]; other site 271848000896 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 271848000897 homodimer interaction site [polypeptide binding]; other site 271848000898 cofactor binding site; other site 271848000899 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 271848000900 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 271848000901 Ubiquitin-like proteins; Region: UBQ; cl00155 271848000902 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 271848000903 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 271848000904 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 271848000905 active site 271848000906 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 271848000907 active site 1 [active] 271848000908 active site 2 [active] 271848000909 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_2; cd07805 271848000910 N- and C-terminal domain interface [polypeptide binding]; other site 271848000911 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 271848000912 active site 271848000913 MgATP binding site [chemical binding]; other site 271848000914 catalytic site [active] 271848000915 metal binding site [ion binding]; metal-binding site 271848000916 xylulose binding site [chemical binding]; other site 271848000917 putative homodimer interface [polypeptide binding]; other site 271848000918 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 271848000919 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 271848000920 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 271848000921 catalytic residue [active] 271848000922 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 271848000923 D-mannose binding lectin; Region: B_lectin; pfam01453 271848000924 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 271848000925 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 271848000926 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 271848000927 catalytic residue [active] 271848000928 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828 271848000929 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 271848000930 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 271848000931 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 271848000932 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848000933 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848000934 dimerization interface [polypeptide binding]; other site 271848000935 Flavin Reductases; Region: FlaRed; cl00801 271848000936 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 271848000937 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848000938 active site 271848000939 phosphorylation site [posttranslational modification] 271848000940 intermolecular recognition site; other site 271848000941 dimerization interface [polypeptide binding]; other site 271848000942 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 271848000943 DNA binding residues [nucleotide binding] 271848000944 dimerization interface [polypeptide binding]; other site 271848000945 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 271848000946 FAD binding domain; Region: FAD_binding_4; pfam01565 271848000947 Berberine and berberine like; Region: BBE; pfam08031 271848000948 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 271848000949 classical (c) SDRs; Region: SDR_c; cd05233 271848000950 NAD(P) binding site [chemical binding]; other site 271848000951 active site 271848000952 Amidase; Region: Amidase; cl11426 271848000953 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 271848000954 SnoaL-like domain; Region: SnoaL_4; pfam13577 271848000955 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 271848000956 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 271848000957 active site 271848000958 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 271848000959 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271848000960 putative active site [active] 271848000961 heme pocket [chemical binding]; other site 271848000962 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271848000963 dimer interface [polypeptide binding]; other site 271848000964 phosphorylation site [posttranslational modification] 271848000965 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848000966 ATP binding site [chemical binding]; other site 271848000967 Mg2+ binding site [ion binding]; other site 271848000968 G-X-G motif; other site 271848000969 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 271848000970 active site 1 [active] 271848000971 dimer interface [polypeptide binding]; other site 271848000972 hexamer interface [polypeptide binding]; other site 271848000973 active site 2 [active] 271848000974 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 271848000975 active site 1 [active] 271848000976 dimer interface [polypeptide binding]; other site 271848000977 hexamer interface [polypeptide binding]; other site 271848000978 active site 2 [active] 271848000979 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 271848000980 inter-subunit interface; other site 271848000981 anthranilate 1,2-dioxygenase, large subunit; Region: anthran_1_2_A; TIGR03228 271848000982 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 271848000983 [2Fe-2S] cluster binding site [ion binding]; other site 271848000984 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 271848000985 putative alpha subunit interface [polypeptide binding]; other site 271848000986 putative active site [active] 271848000987 putative substrate binding site [chemical binding]; other site 271848000988 Fe binding site [ion binding]; other site 271848000989 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848000990 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848000991 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 271848000992 substrate binding pocket [chemical binding]; other site 271848000993 dimerization interface [polypeptide binding]; other site 271848000994 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 271848000995 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 271848000996 FMN-binding pocket [chemical binding]; other site 271848000997 flavin binding motif; other site 271848000998 phosphate binding motif [ion binding]; other site 271848000999 beta-alpha-beta structure motif; other site 271848001000 NAD binding pocket [chemical binding]; other site 271848001001 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 271848001002 catalytic loop [active] 271848001003 iron binding site [ion binding]; other site 271848001004 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 271848001005 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 271848001006 NAD(P) binding site [chemical binding]; other site 271848001007 catalytic residues [active] 271848001008 choline dehydrogenase; Validated; Region: PRK02106 271848001009 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 271848001010 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848001011 Major Facilitator Superfamily; Region: MFS_1; pfam07690 271848001012 putative substrate translocation pore; other site 271848001013 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 271848001014 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 271848001015 trimer interface [polypeptide binding]; other site 271848001016 eyelet of channel; other site 271848001017 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 271848001018 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848001019 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848001020 dimerization interface [polypeptide binding]; other site 271848001021 Helix-turn-helix domain; Region: HTH_18; pfam12833 271848001022 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 271848001023 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 271848001024 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 271848001025 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08269 271848001026 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 271848001027 metabolite-proton symporter; Region: 2A0106; TIGR00883 271848001028 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848001029 putative substrate translocation pore; other site 271848001030 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 271848001031 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 271848001032 active site 271848001033 homodimer interface [polypeptide binding]; other site 271848001034 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 271848001035 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 271848001036 DXD motif; other site 271848001037 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 271848001038 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 271848001039 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 271848001040 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 271848001041 glutaminase active site [active] 271848001042 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 271848001043 dimer interface [polypeptide binding]; other site 271848001044 active site 271848001045 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 271848001046 dimer interface [polypeptide binding]; other site 271848001047 active site 271848001048 gluconate 5-dehydrogenase; Provisional; Region: PRK07523 271848001049 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 271848001050 NADP binding site [chemical binding]; other site 271848001051 homodimer interface [polypeptide binding]; other site 271848001052 active site 271848001053 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 271848001054 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848001055 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 271848001056 dimerization interface [polypeptide binding]; other site 271848001057 substrate binding pocket [chemical binding]; other site 271848001058 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 271848001059 ATP-binding site [chemical binding]; other site 271848001060 Gluconate-6-phosphate binding site [chemical binding]; other site 271848001061 Shikimate kinase; Region: SKI; pfam01202 271848001062 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848001063 D-galactonate transporter; Region: 2A0114; TIGR00893 271848001064 putative substrate translocation pore; other site 271848001065 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 271848001066 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 271848001067 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 271848001068 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 271848001069 DNA-binding interface [nucleotide binding]; DNA binding site 271848001070 HTH-like domain; Region: HTH_21; pfam13276 271848001071 Transposase, Mutator family; Region: Transposase_mut; pfam00872 271848001072 MULE transposase domain; Region: MULE; pfam10551 271848001073 Hemerythrin-like domain; Region: Hr-like; cd12108 271848001074 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 271848001075 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 271848001076 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 271848001077 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 271848001078 Uncharacterized conserved protein [Function unknown]; Region: COG3189 271848001079 Predicted metal-binding protein [General function prediction only]; Region: COG3019 271848001080 IS2 transposase TnpB; Reviewed; Region: PRK09409 271848001081 HTH-like domain; Region: HTH_21; pfam13276 271848001082 Integrase core domain; Region: rve; pfam00665 271848001083 Integrase core domain; Region: rve_3; pfam13683 271848001084 Transposase; Region: HTH_Tnp_1; cl17663 271848001085 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 271848001086 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 271848001087 Uncharacterized conserved protein [Function unknown]; Region: COG3391 271848001088 Beta-lactamase; Region: Beta-lactamase; cl17358 271848001089 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 271848001090 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 271848001091 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 271848001092 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 271848001093 dimerization interface [polypeptide binding]; other site 271848001094 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271848001095 dimer interface [polypeptide binding]; other site 271848001096 phosphorylation site [posttranslational modification] 271848001097 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848001098 ATP binding site [chemical binding]; other site 271848001099 Mg2+ binding site [ion binding]; other site 271848001100 G-X-G motif; other site 271848001101 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 271848001102 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848001103 active site 271848001104 phosphorylation site [posttranslational modification] 271848001105 intermolecular recognition site; other site 271848001106 dimerization interface [polypeptide binding]; other site 271848001107 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 271848001108 DNA binding site [nucleotide binding] 271848001109 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 271848001110 active site 271848001111 catalytic triad [active] 271848001112 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 271848001113 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 271848001114 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 271848001115 putative uracil binding site [chemical binding]; other site 271848001116 putative active site [active] 271848001117 aldolase II superfamily protein; Provisional; Region: PRK07044 271848001118 intersubunit interface [polypeptide binding]; other site 271848001119 active site 271848001120 Zn2+ binding site [ion binding]; other site 271848001121 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 271848001122 dinuclear metal binding motif [ion binding]; other site 271848001123 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 271848001124 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 271848001125 active site 271848001126 metal binding site [ion binding]; metal-binding site 271848001127 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 271848001128 Catalytic domain, repeat 1, of Deoxyribonuclease II and similar proteins; Region: PLDc_DNaseII_1; cd09120 271848001129 Deoxyribonuclease II; Region: DNase_II; pfam03265 271848001130 putative active site [active] 271848001131 catalytic site [active] 271848001132 Catalytic domain, repeat 2, of Deoxyribonuclease II and similar proteins; Region: PLDc_DNaseII_2; cd09121 271848001133 putative active site [active] 271848001134 catalytic site [active] 271848001135 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 271848001136 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 271848001137 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 271848001138 putative metal binding site [ion binding]; other site 271848001139 putative homodimer interface [polypeptide binding]; other site 271848001140 putative homotetramer interface [polypeptide binding]; other site 271848001141 putative homodimer-homodimer interface [polypeptide binding]; other site 271848001142 putative allosteric switch controlling residues; other site 271848001143 Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790 271848001144 Chain length determinant protein; Region: Wzz; cl15801 271848001145 tyrosine kinase; Provisional; Region: PRK11519 271848001146 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 271848001147 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 271848001148 Phospholipid methyltransferase; Region: PEMT; cl17370 271848001149 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 271848001150 peptidase domain interface [polypeptide binding]; other site 271848001151 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 271848001152 active site 271848001153 catalytic triad [active] 271848001154 calcium binding site [ion binding]; other site 271848001155 Protein of unknown function (DUF3268); Region: DUF3268; pfam11672 271848001156 Cache domain; Region: Cache_1; pfam02743 271848001157 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 271848001158 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271848001159 metal binding site [ion binding]; metal-binding site 271848001160 active site 271848001161 I-site; other site 271848001162 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 271848001163 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 271848001164 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 271848001165 short chain dehydrogenase; Provisional; Region: PRK06181 271848001166 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848001167 NAD(P) binding site [chemical binding]; other site 271848001168 active site 271848001169 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 271848001170 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848001171 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848001172 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 271848001173 putative effector binding pocket; other site 271848001174 dimerization interface [polypeptide binding]; other site 271848001175 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 271848001176 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 271848001177 putative C-terminal domain interface [polypeptide binding]; other site 271848001178 putative GSH binding site (G-site) [chemical binding]; other site 271848001179 putative dimer interface [polypeptide binding]; other site 271848001180 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 271848001181 putative N-terminal domain interface [polypeptide binding]; other site 271848001182 putative dimer interface [polypeptide binding]; other site 271848001183 putative substrate binding pocket (H-site) [chemical binding]; other site 271848001184 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 271848001185 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 271848001186 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 271848001187 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 271848001188 FAD binding pocket [chemical binding]; other site 271848001189 FAD binding motif [chemical binding]; other site 271848001190 phosphate binding motif [ion binding]; other site 271848001191 beta-alpha-beta structure motif; other site 271848001192 NAD binding pocket [chemical binding]; other site 271848001193 Heme binding pocket [chemical binding]; other site 271848001194 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 271848001195 catalytic loop [active] 271848001196 iron binding site [ion binding]; other site 271848001197 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 271848001198 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 271848001199 Nucleoside recognition; Region: Gate; pfam07670 271848001200 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 271848001201 deoxyribose-phosphate aldolase; Provisional; Region: PRK05283 271848001202 catalytic residue [active] 271848001203 thymidine phosphorylase; Region: T_phosphoryl; TIGR02643 271848001204 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 271848001205 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 271848001206 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 271848001207 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 271848001208 active site 271848001209 catalytic motif [active] 271848001210 Zn binding site [ion binding]; other site 271848001211 periplasmic protein; Provisional; Region: PRK10568 271848001212 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 271848001213 BON domain; Region: BON; pfam04972 271848001214 BON domain; Region: BON; pfam04972 271848001215 6-phosphofructokinase 2; Provisional; Region: PRK10294 271848001216 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 271848001217 putative substrate binding site [chemical binding]; other site 271848001218 putative ATP binding site [chemical binding]; other site 271848001219 acetate kinase; Provisional; Region: PRK07058 271848001220 propionate/acetate kinase; Provisional; Region: PRK12379 271848001221 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190 271848001222 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 271848001223 dimer interaction site [polypeptide binding]; other site 271848001224 substrate-binding tunnel; other site 271848001225 active site 271848001226 catalytic site [active] 271848001227 substrate binding site [chemical binding]; other site 271848001228 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 271848001229 Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551 271848001230 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 271848001231 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 271848001232 F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597 271848001233 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 271848001234 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 271848001235 alpha subunit interaction interface [polypeptide binding]; other site 271848001236 Walker A motif; other site 271848001237 ATP binding site [chemical binding]; other site 271848001238 Walker B motif; other site 271848001239 inhibitor binding site; inhibition site 271848001240 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 271848001241 F0F1 ATP synthase subunit epsilon; Provisional; Region: PRK13447 271848001242 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 271848001243 gamma subunit interface [polypeptide binding]; other site 271848001244 epsilon subunit interface [polypeptide binding]; other site 271848001245 LBP interface [polypeptide binding]; other site 271848001246 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 271848001247 F0F1 ATP synthase subunit A; Provisional; Region: PRK13421 271848001248 F0F1 ATP synthase subunit C; Provisional; Region: PRK13468 271848001249 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 271848001250 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 271848001251 type III secretion apparatus H+-transporting two-sector ATPase; Region: III_secr_ATP; TIGR02546 271848001252 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 271848001253 Walker A motif; other site 271848001254 ATP binding site [chemical binding]; other site 271848001255 Walker B motif; other site 271848001256 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 271848001257 ATP synthase; Region: ATP-synt; pfam00231 271848001258 core domain interface [polypeptide binding]; other site 271848001259 delta subunit interface [polypeptide binding]; other site 271848001260 epsilon subunit interface [polypeptide binding]; other site 271848001261 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 271848001262 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 271848001263 NAD binding site [chemical binding]; other site 271848001264 substrate binding site [chemical binding]; other site 271848001265 catalytic Zn binding site [ion binding]; other site 271848001266 tetramer interface [polypeptide binding]; other site 271848001267 structural Zn binding site [ion binding]; other site 271848001268 Transposase, Mutator family; Region: Transposase_mut; pfam00872 271848001269 MULE transposase domain; Region: MULE; pfam10551 271848001270 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 271848001271 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 271848001272 Cytochrome P450; Region: p450; pfam00067 271848001273 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 271848001274 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 271848001275 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 271848001276 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 271848001277 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 271848001278 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 271848001279 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 271848001280 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 271848001281 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 271848001282 Walker A/P-loop; other site 271848001283 ATP binding site [chemical binding]; other site 271848001284 Q-loop/lid; other site 271848001285 ABC transporter signature motif; other site 271848001286 Walker B; other site 271848001287 D-loop; other site 271848001288 H-loop/switch region; other site 271848001289 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 271848001290 Walker A/P-loop; other site 271848001291 ATP binding site [chemical binding]; other site 271848001292 Q-loop/lid; other site 271848001293 ABC transporter signature motif; other site 271848001294 Walker B; other site 271848001295 D-loop; other site 271848001296 H-loop/switch region; other site 271848001297 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 271848001298 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 271848001299 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 271848001300 HlyD family secretion protein; Region: HlyD_3; pfam13437 271848001301 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 271848001302 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 271848001303 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 271848001304 Ligand Binding Site [chemical binding]; other site 271848001305 Protein of unknown function (DUF2964); Region: DUF2964; pfam11177 271848001306 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 271848001307 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 271848001308 FtsX-like permease family; Region: FtsX; pfam02687 271848001309 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 271848001310 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 271848001311 Walker A/P-loop; other site 271848001312 ATP binding site [chemical binding]; other site 271848001313 Q-loop/lid; other site 271848001314 ABC transporter signature motif; other site 271848001315 Walker B; other site 271848001316 D-loop; other site 271848001317 H-loop/switch region; other site 271848001318 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 271848001319 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 271848001320 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 271848001321 Putative catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases which consist of a 5-stranded beta/alpha barrel; Region: CE4_DAC_u4_5s; cd10973 271848001322 putative active site [active] 271848001323 putative metal binding site [ion binding]; other site 271848001324 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 271848001325 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 271848001326 dimer interface [polypeptide binding]; other site 271848001327 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 271848001328 putative CheW interface [polypeptide binding]; other site 271848001329 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 271848001330 ligand-binding site [chemical binding]; other site 271848001331 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 271848001332 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 271848001333 BON domain; Region: BON; pfam04972 271848001334 BON domain; Region: BON; pfam04972 271848001335 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 271848001336 Protein of unknown function (DUF3564); Region: DUF3564; pfam12087 271848001337 Cytochrome c; Region: Cytochrom_C; cl11414 271848001338 Protein of unknown function (DUF3562); Region: DUF3562; pfam12085 271848001339 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 271848001340 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 271848001341 putative NAD(P) binding site [chemical binding]; other site 271848001342 putative substrate binding site [chemical binding]; other site 271848001343 catalytic Zn binding site [ion binding]; other site 271848001344 structural Zn binding site [ion binding]; other site 271848001345 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 271848001346 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 271848001347 ligand binding site [chemical binding]; other site 271848001348 flexible hinge region; other site 271848001349 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 271848001350 putative switch regulator; other site 271848001351 non-specific DNA interactions [nucleotide binding]; other site 271848001352 DNA binding site [nucleotide binding] 271848001353 sequence specific DNA binding site [nucleotide binding]; other site 271848001354 putative cAMP binding site [chemical binding]; other site 271848001355 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 271848001356 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 271848001357 NAD(P) binding site [chemical binding]; other site 271848001358 homotetramer interface [polypeptide binding]; other site 271848001359 homodimer interface [polypeptide binding]; other site 271848001360 active site 271848001361 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 271848001362 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 271848001363 Beta-Casp domain; Region: Beta-Casp; smart01027 271848001364 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 271848001365 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 271848001366 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 271848001367 lysine transporter; Provisional; Region: PRK10836 271848001368 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 271848001369 Transposase; Region: DDE_Tnp_ISL3; pfam01610 271848001370 Isochorismatase family; Region: Isochorismatase; pfam00857 271848001371 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 271848001372 catalytic triad [active] 271848001373 conserved cis-peptide bond; other site 271848001374 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 271848001375 MarR family; Region: MarR_2; cl17246 271848001376 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 271848001377 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 271848001378 substrate binding pocket [chemical binding]; other site 271848001379 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 271848001380 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 271848001381 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937 271848001382 putative NAD(P) binding site [chemical binding]; other site 271848001383 active site 271848001384 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 271848001385 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 271848001386 catalytic loop [active] 271848001387 iron binding site [ion binding]; other site 271848001388 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 271848001389 FAD binding pocket [chemical binding]; other site 271848001390 FAD binding motif [chemical binding]; other site 271848001391 phosphate binding motif [ion binding]; other site 271848001392 beta-alpha-beta structure motif; other site 271848001393 NAD binding pocket [chemical binding]; other site 271848001394 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 271848001395 inter-subunit interface; other site 271848001396 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 271848001397 Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542 271848001398 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 271848001399 putative alpha subunit interface [polypeptide binding]; other site 271848001400 putative active site [active] 271848001401 putative substrate binding site [chemical binding]; other site 271848001402 Fe binding site [ion binding]; other site 271848001403 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 271848001404 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848001405 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in benzoate catabolism; contains the type 2 periplasmic binding fold; Region: PBP2_BenM_CatM_CatR; cd08445 271848001406 dimerizarion interface [polypeptide binding]; other site 271848001407 CrgA pocket; other site 271848001408 substrate binding pocket [chemical binding]; other site 271848001409 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848001410 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 271848001411 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 271848001412 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848001413 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 271848001414 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 271848001415 active site 271848001416 FMN binding site [chemical binding]; other site 271848001417 2,4-decadienoyl-CoA binding site; other site 271848001418 catalytic residue [active] 271848001419 4Fe-4S cluster binding site [ion binding]; other site 271848001420 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 271848001421 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 271848001422 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 271848001423 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 271848001424 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 271848001425 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 271848001426 D-pathway; other site 271848001427 Putative ubiquinol binding site [chemical binding]; other site 271848001428 Low-spin heme (heme b) binding site [chemical binding]; other site 271848001429 Putative water exit pathway; other site 271848001430 Binuclear center (heme o3/CuB) [ion binding]; other site 271848001431 K-pathway; other site 271848001432 Putative proton exit pathway; other site 271848001433 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 271848001434 Subunit I/III interface [polypeptide binding]; other site 271848001435 Subunit III/IV interface [polypeptide binding]; other site 271848001436 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 271848001437 muconolactone delta-isomerase; Region: muco_delta; TIGR03221 271848001438 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 271848001439 Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460 271848001440 dimer interface [polypeptide binding]; other site 271848001441 active site 271848001442 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 271848001443 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 271848001444 metal binding site [ion binding]; metal-binding site 271848001445 substrate binding pocket [chemical binding]; other site 271848001446 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 271848001447 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848001448 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848001449 dimerization interface [polypeptide binding]; other site 271848001450 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 271848001451 Rieske non-heme iron oxygenase (RO) family, Ortho-halobenzoate-1,2-dioxygenase (OHBDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of OHBDO, salicylate 5-hydroxylase (S5H); Region: Rieske_RO_Alpha_OHBDO_like; cd03545 271848001452 C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880 271848001453 putative alpha subunit interface [polypeptide binding]; other site 271848001454 putative active site [active] 271848001455 putative substrate binding site [chemical binding]; other site 271848001456 Fe binding site [ion binding]; other site 271848001457 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 271848001458 inter-subunit interface; other site 271848001459 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 271848001460 [2Fe-2S] cluster binding site [ion binding]; other site 271848001461 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 271848001462 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 271848001463 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 271848001464 HIT family signature motif; other site 271848001465 catalytic residue [active] 271848001466 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 271848001467 PLD-like domain; Region: PLDc_2; pfam13091 271848001468 putative active site [active] 271848001469 catalytic site [active] 271848001470 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 271848001471 PLD-like domain; Region: PLDc_2; pfam13091 271848001472 putative active site [active] 271848001473 catalytic site [active] 271848001474 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 271848001475 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 271848001476 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 271848001477 Coenzyme A binding pocket [chemical binding]; other site 271848001478 Protein of unknown function (DUF445); Region: DUF445; pfam04286 271848001479 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 271848001480 acetolactate synthase; Reviewed; Region: PRK08322 271848001481 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 271848001482 PYR/PP interface [polypeptide binding]; other site 271848001483 dimer interface [polypeptide binding]; other site 271848001484 TPP binding site [chemical binding]; other site 271848001485 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 271848001486 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 271848001487 TPP-binding site [chemical binding]; other site 271848001488 dimer interface [polypeptide binding]; other site 271848001489 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 271848001490 Aldehyde dehydrogenase family 21A1-like; Region: ALDH_F21_RNP123; cd07147 271848001491 NAD(P) binding site [chemical binding]; other site 271848001492 catalytic residues [active] 271848001493 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 271848001494 active site 271848001495 catalytic site [active] 271848001496 Response regulator receiver domain; Region: Response_reg; pfam00072 271848001497 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848001498 active site 271848001499 phosphorylation site [posttranslational modification] 271848001500 intermolecular recognition site; other site 271848001501 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 271848001502 dimerization interface [polypeptide binding]; other site 271848001503 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271848001504 dimer interface [polypeptide binding]; other site 271848001505 phosphorylation site [posttranslational modification] 271848001506 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848001507 ATP binding site [chemical binding]; other site 271848001508 Mg2+ binding site [ion binding]; other site 271848001509 G-X-G motif; other site 271848001510 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 271848001511 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 271848001512 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 271848001513 dimerization interface [polypeptide binding]; other site 271848001514 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 271848001515 dimer interface [polypeptide binding]; other site 271848001516 putative CheW interface [polypeptide binding]; other site 271848001517 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 271848001518 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 271848001519 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848001520 S-adenosylmethionine binding site [chemical binding]; other site 271848001521 TPR repeat; Region: TPR_11; pfam13414 271848001522 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 271848001523 binding surface 271848001524 TPR motif; other site 271848001525 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 271848001526 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 271848001527 putative binding surface; other site 271848001528 active site 271848001529 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 271848001530 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848001531 ATP binding site [chemical binding]; other site 271848001532 Mg2+ binding site [ion binding]; other site 271848001533 G-X-G motif; other site 271848001534 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 271848001535 Response regulator receiver domain; Region: Response_reg; pfam00072 271848001536 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848001537 active site 271848001538 phosphorylation site [posttranslational modification] 271848001539 intermolecular recognition site; other site 271848001540 dimerization interface [polypeptide binding]; other site 271848001541 chemotaxis-specific methylesterase; Provisional; Region: PRK12555 271848001542 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848001543 active site 271848001544 phosphorylation site [posttranslational modification] 271848001545 intermolecular recognition site; other site 271848001546 CheB methylesterase; Region: CheB_methylest; pfam01339 271848001547 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 271848001548 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 271848001549 motif II; other site 271848001550 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 271848001551 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 271848001552 Cl- selectivity filter; other site 271848001553 Cl- binding residues [ion binding]; other site 271848001554 pore gating glutamate residue; other site 271848001555 dimer interface [polypeptide binding]; other site 271848001556 CAAX protease self-immunity; Region: Abi; pfam02517 271848001557 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 271848001558 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 271848001559 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 271848001560 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 271848001561 active site 271848001562 HIGH motif; other site 271848001563 dimer interface [polypeptide binding]; other site 271848001564 KMSKS motif; other site 271848001565 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 271848001566 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 271848001567 conserved cys residue [active] 271848001568 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848001569 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848001570 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 271848001571 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 271848001572 conserved cys residue [active] 271848001573 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 271848001574 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 271848001575 Walker A/P-loop; other site 271848001576 ATP binding site [chemical binding]; other site 271848001577 Q-loop/lid; other site 271848001578 ABC transporter signature motif; other site 271848001579 Walker B; other site 271848001580 D-loop; other site 271848001581 H-loop/switch region; other site 271848001582 Dyp-type peroxidase family; Region: Dyp_perox_fam; TIGR01413 271848001583 Domain of unknown function (DUF3472); Region: DUF3472; pfam11958 271848001584 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 271848001585 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848001586 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848001587 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 271848001588 substrate binding pocket [chemical binding]; other site 271848001589 dimerization interface [polypeptide binding]; other site 271848001590 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 271848001591 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 271848001592 active site 271848001593 Phosphotransferase enzyme family; Region: APH; pfam01636 271848001594 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 271848001595 putative active site [active] 271848001596 putative substrate binding site [chemical binding]; other site 271848001597 ATP binding site [chemical binding]; other site 271848001598 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 271848001599 catalytic core [active] 271848001600 short chain dehydrogenase; Provisional; Region: PRK07035 271848001601 classical (c) SDRs; Region: SDR_c; cd05233 271848001602 NAD(P) binding site [chemical binding]; other site 271848001603 active site 271848001604 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848001605 short chain dehydrogenase; Validated; Region: PRK07069 271848001606 NAD(P) binding site [chemical binding]; other site 271848001607 active site 271848001608 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 271848001609 Prostaglandin dehydrogenases; Region: PGDH; cd05288 271848001610 NAD(P) binding site [chemical binding]; other site 271848001611 substrate binding site [chemical binding]; other site 271848001612 dimer interface [polypeptide binding]; other site 271848001613 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 271848001614 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 271848001615 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 271848001616 N-terminal plug; other site 271848001617 ligand-binding site [chemical binding]; other site 271848001618 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 271848001619 Domain of unknown function DUF20; Region: UPF0118; pfam01594 271848001620 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 271848001621 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 271848001622 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 271848001623 generic binding surface I; other site 271848001624 generic binding surface II; other site 271848001625 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 271848001626 putative active site [active] 271848001627 putative catalytic site [active] 271848001628 putative Mg binding site IVb [ion binding]; other site 271848001629 putative phosphate binding site [ion binding]; other site 271848001630 putative DNA binding site [nucleotide binding]; other site 271848001631 putative Mg binding site IVa [ion binding]; other site 271848001632 YCII-related domain; Region: YCII; cl00999 271848001633 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 271848001634 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 271848001635 putative hydrophobic ligand binding site [chemical binding]; other site 271848001636 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 271848001637 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 271848001638 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 271848001639 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 271848001640 amidase catalytic site [active] 271848001641 Zn binding residues [ion binding]; other site 271848001642 substrate binding site [chemical binding]; other site 271848001643 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 271848001644 Rubrerythrin [Energy production and conversion]; Region: COG1592 271848001645 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 271848001646 binuclear metal center [ion binding]; other site 271848001647 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 271848001648 Cysteine-rich domain; Region: CCG; pfam02754 271848001649 Protein of unknown function (DUF3501); Region: DUF3501; pfam12007 271848001650 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 271848001651 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 271848001652 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 271848001653 Substrate binding site; other site 271848001654 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 271848001655 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 271848001656 Bacterial sugar transferase; Region: Bac_transf; pfam02397 271848001657 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 271848001658 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 271848001659 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 271848001660 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 271848001661 Low molecular weight phosphatase family; Region: LMWPc; cd00115 271848001662 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 271848001663 active site 271848001664 polysaccharide export protein Wza; Provisional; Region: PRK15078 271848001665 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 271848001666 SLBB domain; Region: SLBB; pfam10531 271848001667 SLBB domain; Region: SLBB; pfam10531 271848001668 tyrosine kinase; Provisional; Region: PRK11519 271848001669 Chain length determinant protein; Region: Wzz; cl15801 271848001670 Chain length determinant protein; Region: Wzz; cl15801 271848001671 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 271848001672 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 271848001673 P-loop; other site 271848001674 Magnesium ion binding site [ion binding]; other site 271848001675 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 271848001676 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 271848001677 DXD motif; other site 271848001678 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 271848001679 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 271848001680 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 271848001681 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 271848001682 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 271848001683 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 271848001684 Cupin domain; Region: Cupin_2; cl17218 271848001685 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 271848001686 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848001687 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848001688 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 271848001689 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 271848001690 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 271848001691 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 271848001692 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 271848001693 RES domain; Region: RES; smart00953 271848001694 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 271848001695 active site 271848001696 metal binding site [ion binding]; metal-binding site 271848001697 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 271848001698 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_5; cd08898 271848001699 putative hydrophobic ligand binding site [chemical binding]; other site 271848001700 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 271848001701 dimerization interface [polypeptide binding]; other site 271848001702 putative DNA binding site [nucleotide binding]; other site 271848001703 putative Zn2+ binding site [ion binding]; other site 271848001704 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 271848001705 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 271848001706 acyl-activating enzyme (AAE) consensus motif; other site 271848001707 AMP binding site [chemical binding]; other site 271848001708 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 271848001709 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 271848001710 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 271848001711 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 271848001712 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 271848001713 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 271848001714 homodimer interface [polypeptide binding]; other site 271848001715 substrate-cofactor binding pocket; other site 271848001716 catalytic residue [active] 271848001717 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 271848001718 acetaldehyde dehydrogenase (acetylating); Region: ac_ald_DH_ac; TIGR03215 271848001719 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 271848001720 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 271848001721 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 271848001722 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 271848001723 active site 271848001724 catalytic residues [active] 271848001725 metal binding site [ion binding]; metal-binding site 271848001726 DmpG-like communication domain; Region: DmpG_comm; pfam07836 271848001727 Cupin domain; Region: Cupin_2; cl17218 271848001728 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 271848001729 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 271848001730 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 271848001731 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 271848001732 Autoinducer binding domain; Region: Autoind_bind; pfam03472 271848001733 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 271848001734 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 271848001735 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848001736 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 271848001737 Helix-turn-helix domain; Region: HTH_28; pfam13518 271848001738 Winged helix-turn helix; Region: HTH_29; pfam13551 271848001739 Winged helix-turn helix; Region: HTH_33; pfam13592 271848001740 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 271848001741 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 271848001742 phosphate binding site [ion binding]; other site 271848001743 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 271848001744 putative deacylase active site [active] 271848001745 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848001746 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 271848001747 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 271848001748 active site 271848001749 catalytic site [active] 271848001750 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 271848001751 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 271848001752 thiamine phosphate binding site [chemical binding]; other site 271848001753 active site 271848001754 pyrophosphate binding site [ion binding]; other site 271848001755 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 271848001756 Domain of unknown function DUF21; Region: DUF21; pfam01595 271848001757 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 271848001758 Transporter associated domain; Region: CorC_HlyC; smart01091 271848001759 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 271848001760 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271848001761 dimer interface [polypeptide binding]; other site 271848001762 phosphorylation site [posttranslational modification] 271848001763 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 271848001764 EamA-like transporter family; Region: EamA; pfam00892 271848001765 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848001766 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848001767 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848001768 dimerization interface [polypeptide binding]; other site 271848001769 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 271848001770 active site 1 [active] 271848001771 dimer interface [polypeptide binding]; other site 271848001772 hexamer interface [polypeptide binding]; other site 271848001773 active site 2 [active] 271848001774 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 271848001775 dimer interface [polypeptide binding]; other site 271848001776 hexamer interface [polypeptide binding]; other site 271848001777 active site 2 [active] 271848001778 CHAD domain; Region: CHAD; pfam05235 271848001779 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 271848001780 molybdenum-pterin binding domain; Region: Mop; TIGR00638 271848001781 TOBE domain; Region: TOBE; cl01440 271848001782 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 271848001783 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 271848001784 Walker A/P-loop; other site 271848001785 ATP binding site [chemical binding]; other site 271848001786 Q-loop/lid; other site 271848001787 ABC transporter signature motif; other site 271848001788 Walker B; other site 271848001789 D-loop; other site 271848001790 H-loop/switch region; other site 271848001791 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848001792 dimer interface [polypeptide binding]; other site 271848001793 conserved gate region; other site 271848001794 putative PBP binding loops; other site 271848001795 ABC-ATPase subunit interface; other site 271848001796 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 271848001797 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 271848001798 Esterase PHB depolymerase; Region: Esterase_phd; pfam10503 271848001799 Protein of unknown function (DUF3563); Region: DUF3563; pfam12086 271848001800 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 271848001801 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 271848001802 MarR family; Region: MarR; pfam01047 271848001803 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 271848001804 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 271848001805 putative active site [active] 271848001806 putative substrate binding site [chemical binding]; other site 271848001807 ATP binding site [chemical binding]; other site 271848001808 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 271848001809 AMP nucleosidase; Provisional; Region: PRK08292 271848001810 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 271848001811 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 271848001812 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 271848001813 DNA polymerase I; Provisional; Region: PRK05755 271848001814 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 271848001815 active site 271848001816 metal binding site 1 [ion binding]; metal-binding site 271848001817 putative 5' ssDNA interaction site; other site 271848001818 metal binding site 3; metal-binding site 271848001819 metal binding site 2 [ion binding]; metal-binding site 271848001820 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 271848001821 putative DNA binding site [nucleotide binding]; other site 271848001822 putative metal binding site [ion binding]; other site 271848001823 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 271848001824 active site 271848001825 catalytic site [active] 271848001826 substrate binding site [chemical binding]; other site 271848001827 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 271848001828 active site 271848001829 DNA binding site [nucleotide binding] 271848001830 catalytic site [active] 271848001831 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 271848001832 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 271848001833 Predicted membrane protein [Function unknown]; Region: COG4655 271848001834 Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977 271848001835 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 271848001836 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 271848001837 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 271848001838 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 271848001839 active site residue [active] 271848001840 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 271848001841 active site residue [active] 271848001842 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 271848001843 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 271848001844 [2Fe-2S] cluster binding site [ion binding]; other site 271848001845 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 271848001846 alpha subunit interface [polypeptide binding]; other site 271848001847 active site 271848001848 substrate binding site [chemical binding]; other site 271848001849 Fe binding site [ion binding]; other site 271848001850 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 271848001851 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 271848001852 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 271848001853 substrate binding pocket [chemical binding]; other site 271848001854 chain length determination region; other site 271848001855 substrate-Mg2+ binding site; other site 271848001856 catalytic residues [active] 271848001857 aspartate-rich region 1; other site 271848001858 active site lid residues [active] 271848001859 aspartate-rich region 2; other site 271848001860 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 271848001861 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 271848001862 TPP-binding site; other site 271848001863 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 271848001864 PYR/PP interface [polypeptide binding]; other site 271848001865 dimer interface [polypeptide binding]; other site 271848001866 TPP binding site [chemical binding]; other site 271848001867 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 271848001868 putative GTP cyclohydrolase; Provisional; Region: PRK13674 271848001869 UGMP family protein; Validated; Region: PRK09604 271848001870 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 271848001871 Predicted flavoproteins [General function prediction only]; Region: COG2081 271848001872 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 271848001873 Yqey-like protein; Region: YqeY; pfam09424 271848001874 DNA primase; Validated; Region: dnaG; PRK05667 271848001875 CHC2 zinc finger; Region: zf-CHC2; pfam01807 271848001876 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 271848001877 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 271848001878 active site 271848001879 metal binding site [ion binding]; metal-binding site 271848001880 interdomain interaction site; other site 271848001881 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 271848001882 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879 271848001883 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 271848001884 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 271848001885 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 271848001886 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 271848001887 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 271848001888 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 271848001889 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 271848001890 DNA binding residues [nucleotide binding] 271848001891 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 271848001892 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 271848001893 active site 271848001894 DNA binding site [nucleotide binding] 271848001895 Int/Topo IB signature motif; other site 271848001896 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 271848001897 Integrase core domain; Region: rve; pfam00665 271848001898 Transposase, Mutator family; Region: Transposase_mut; pfam00872 271848001899 MULE transposase domain; Region: MULE; pfam10551 271848001900 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 271848001901 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848001902 S-adenosylmethionine binding site [chemical binding]; other site 271848001903 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 271848001904 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 271848001905 NAD-dependent deacetylase; Provisional; Region: PRK05333 271848001906 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409 271848001907 NAD+ binding site [chemical binding]; other site 271848001908 substrate binding site [chemical binding]; other site 271848001909 Zn binding site [ion binding]; other site 271848001910 Protein of unknown function (DUF938); Region: DUF938; pfam06080 271848001911 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 271848001912 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 271848001913 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 271848001914 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 271848001915 Cupin domain; Region: Cupin_2; cl17218 271848001916 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 271848001917 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 271848001918 E3 interaction surface; other site 271848001919 lipoyl attachment site [posttranslational modification]; other site 271848001920 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 271848001921 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 271848001922 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 271848001923 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 271848001924 N-terminal plug; other site 271848001925 ligand-binding site [chemical binding]; other site 271848001926 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 271848001927 Lipase (class 2); Region: Lipase_2; pfam01674 271848001928 PGAP1-like protein; Region: PGAP1; pfam07819 271848001929 lipase chaperone; Provisional; Region: PRK01294 271848001930 Proteobacterial lipase chaperone protein; Region: Lipase_chap; cl02224 271848001931 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 271848001932 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 271848001933 DNA-binding site [nucleotide binding]; DNA binding site 271848001934 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 271848001935 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848001936 homodimer interface [polypeptide binding]; other site 271848001937 catalytic residue [active] 271848001938 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 271848001939 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 271848001940 Walker A/P-loop; other site 271848001941 ATP binding site [chemical binding]; other site 271848001942 Q-loop/lid; other site 271848001943 ABC transporter signature motif; other site 271848001944 Walker B; other site 271848001945 D-loop; other site 271848001946 H-loop/switch region; other site 271848001947 TOBE domain; Region: TOBE_2; pfam08402 271848001948 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 271848001949 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 271848001950 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848001951 dimer interface [polypeptide binding]; other site 271848001952 conserved gate region; other site 271848001953 putative PBP binding loops; other site 271848001954 ABC-ATPase subunit interface; other site 271848001955 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 271848001956 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848001957 putative PBP binding loops; other site 271848001958 dimer interface [polypeptide binding]; other site 271848001959 ABC-ATPase subunit interface; other site 271848001960 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 271848001961 peptidase domain interface [polypeptide binding]; other site 271848001962 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 271848001963 active site 271848001964 catalytic triad [active] 271848001965 calcium binding site [ion binding]; other site 271848001966 Common central domain of tyrosinase; Region: Tyrosinase; pfam00264 271848001967 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 271848001968 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 271848001969 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 271848001970 Cytochrome c; Region: Cytochrom_C; pfam00034 271848001971 aconitate hydratase; Provisional; Region: acnA; PRK12881 271848001972 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 271848001973 substrate binding site [chemical binding]; other site 271848001974 ligand binding site [chemical binding]; other site 271848001975 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 271848001976 substrate binding site [chemical binding]; other site 271848001977 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 271848001978 2-methylcitrate dehydratase; Region: prpD; TIGR02330 271848001979 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 271848001980 malate dehydrogenase; Provisional; Region: PRK05442 271848001981 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 271848001982 NAD(P) binding site [chemical binding]; other site 271848001983 dimer interface [polypeptide binding]; other site 271848001984 malate binding site [chemical binding]; other site 271848001985 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 271848001986 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 271848001987 DNA-binding site [nucleotide binding]; DNA binding site 271848001988 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 271848001989 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 271848001990 Iron-sulfur protein interface; other site 271848001991 proximal quinone binding site [chemical binding]; other site 271848001992 SdhD (CybS) interface [polypeptide binding]; other site 271848001993 proximal heme binding site [chemical binding]; other site 271848001994 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 271848001995 SdhC subunit interface [polypeptide binding]; other site 271848001996 proximal heme binding site [chemical binding]; other site 271848001997 cardiolipin binding site; other site 271848001998 Iron-sulfur protein interface; other site 271848001999 proximal quinone binding site [chemical binding]; other site 271848002000 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057 271848002001 L-aspartate oxidase; Provisional; Region: PRK06175 271848002002 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 271848002003 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 271848002004 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 271848002005 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 271848002006 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 271848002007 dimer interface [polypeptide binding]; other site 271848002008 active site 271848002009 citrylCoA binding site [chemical binding]; other site 271848002010 NADH binding [chemical binding]; other site 271848002011 cationic pore residues; other site 271848002012 oxalacetate/citrate binding site [chemical binding]; other site 271848002013 coenzyme A binding site [chemical binding]; other site 271848002014 catalytic triad [active] 271848002015 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 271848002016 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 271848002017 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 271848002018 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 271848002019 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 271848002020 2-oxoacid dehydrogenase subunit E1; Provisional; Region: PRK13012 271848002021 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 271848002022 dimer interface [polypeptide binding]; other site 271848002023 TPP-binding site [chemical binding]; other site 271848002024 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 271848002025 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 271848002026 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 271848002027 putative DNA binding site [nucleotide binding]; other site 271848002028 putative Zn2+ binding site [ion binding]; other site 271848002029 AsnC family; Region: AsnC_trans_reg; pfam01037 271848002030 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 271848002031 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 271848002032 substrate binding site [chemical binding]; other site 271848002033 ligand binding site [chemical binding]; other site 271848002034 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 271848002035 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 271848002036 substrate binding site [chemical binding]; other site 271848002037 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 271848002038 tartrate dehydrogenase; Region: TTC; TIGR02089 271848002039 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 271848002040 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 271848002041 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 271848002042 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 271848002043 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 271848002044 dimerization interface 3.5A [polypeptide binding]; other site 271848002045 active site 271848002046 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 271848002047 active site 271848002048 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 271848002049 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 271848002050 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848002051 catalytic residue [active] 271848002052 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 271848002053 DNA methylase; Region: N6_N4_Mtase; pfam01555 271848002054 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 271848002055 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 271848002056 substrate binding site [chemical binding]; other site 271848002057 active site 271848002058 catalytic residues [active] 271848002059 heterodimer interface [polypeptide binding]; other site 271848002060 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 271848002061 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 271848002062 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 271848002063 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 271848002064 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 271848002065 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147 271848002066 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 271848002067 Colicin V production protein; Region: Colicin_V; pfam02674 271848002068 amidophosphoribosyltransferase; Provisional; Region: PRK09246 271848002069 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 271848002070 active site 271848002071 tetramer interface [polypeptide binding]; other site 271848002072 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 271848002073 active site 271848002074 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 271848002075 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 271848002076 homodimer interface [polypeptide binding]; other site 271848002077 substrate-cofactor binding pocket; other site 271848002078 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848002079 catalytic residue [active] 271848002080 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 271848002081 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 271848002082 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848002083 NAD(P) binding site [chemical binding]; other site 271848002084 active site 271848002085 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 271848002086 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 271848002087 NADP-binding site; other site 271848002088 homotetramer interface [polypeptide binding]; other site 271848002089 substrate binding site [chemical binding]; other site 271848002090 homodimer interface [polypeptide binding]; other site 271848002091 active site 271848002092 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 271848002093 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 271848002094 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 271848002095 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 271848002096 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 271848002097 putative ADP-binding pocket [chemical binding]; other site 271848002098 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 271848002099 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 271848002100 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 271848002101 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 271848002102 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 271848002103 active site 271848002104 tetramer interface; other site 271848002105 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 271848002106 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 271848002107 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 271848002108 trimer interface [polypeptide binding]; other site 271848002109 eyelet of channel; other site 271848002110 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 271848002111 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 271848002112 active site 271848002113 Zn binding site [ion binding]; other site 271848002114 Uncharacterized conserved protein [Function unknown]; Region: COG1434 271848002115 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 271848002116 putative active site [active] 271848002117 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 271848002118 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 271848002119 [4Fe-4S] binding site [ion binding]; other site 271848002120 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 271848002121 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 271848002122 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 271848002123 molybdopterin cofactor binding site; other site 271848002124 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 271848002125 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 271848002126 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 271848002127 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 271848002128 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 271848002129 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 271848002130 selenocysteine synthase; Provisional; Region: PRK04311 271848002131 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 271848002132 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 271848002133 catalytic residue [active] 271848002134 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 271848002135 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 271848002136 G1 box; other site 271848002137 putative GEF interaction site [polypeptide binding]; other site 271848002138 GTP/Mg2+ binding site [chemical binding]; other site 271848002139 Switch I region; other site 271848002140 G2 box; other site 271848002141 G3 box; other site 271848002142 Switch II region; other site 271848002143 G4 box; other site 271848002144 G5 box; other site 271848002145 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 271848002146 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 271848002147 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 271848002148 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 271848002149 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 271848002150 Transposase; Region: HTH_Tnp_1; cl17663 271848002151 HTH-like domain; Region: HTH_21; pfam13276 271848002152 Integrase core domain; Region: rve; pfam00665 271848002153 Avidin family; Region: Avidin; pfam01382 271848002154 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 271848002155 Amidase; Region: Amidase; pfam01425 271848002156 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 271848002157 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 271848002158 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 271848002159 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 271848002160 Transcriptional regulator [Transcription]; Region: IclR; COG1414 271848002161 Bacterial transcriptional regulator; Region: IclR; pfam01614 271848002162 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 271848002163 Cytochrome P450; Region: p450; cl12078 271848002164 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 271848002165 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 271848002166 FMN-binding pocket [chemical binding]; other site 271848002167 flavin binding motif; other site 271848002168 phosphate binding motif [ion binding]; other site 271848002169 beta-alpha-beta structure motif; other site 271848002170 NAD binding pocket [chemical binding]; other site 271848002171 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 271848002172 catalytic loop [active] 271848002173 iron binding site [ion binding]; other site 271848002174 benzoate transport; Region: 2A0115; TIGR00895 271848002175 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848002176 putative substrate translocation pore; other site 271848002177 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 271848002178 active site 271848002179 nucleophile elbow; other site 271848002180 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 271848002181 Cu(I) binding site [ion binding]; other site 271848002182 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 271848002183 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 271848002184 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 271848002185 putative sugar binding sites [chemical binding]; other site 271848002186 Q-X-W motif; other site 271848002187 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 271848002188 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 271848002189 putative sugar binding sites [chemical binding]; other site 271848002190 Q-X-W motif; other site 271848002191 Kelch motif; Region: Kelch_6; pfam13964 271848002192 C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851 271848002193 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 271848002194 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848002195 active site 271848002196 phosphorylation site [posttranslational modification] 271848002197 intermolecular recognition site; other site 271848002198 dimerization interface [polypeptide binding]; other site 271848002199 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 271848002200 Zn2+ binding site [ion binding]; other site 271848002201 Mg2+ binding site [ion binding]; other site 271848002202 Uncharacterized conserved protein [Function unknown]; Region: COG3287 271848002203 FIST N domain; Region: FIST; pfam08495 271848002204 FIST C domain; Region: FIST_C; pfam10442 271848002205 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848002206 ATP binding site [chemical binding]; other site 271848002207 Mg2+ binding site [ion binding]; other site 271848002208 G-X-G motif; other site 271848002209 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 271848002210 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848002211 putative substrate translocation pore; other site 271848002212 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848002213 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848002214 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848002215 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 271848002216 putative effector binding pocket; other site 271848002217 dimerization interface [polypeptide binding]; other site 271848002218 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 271848002219 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 271848002220 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 271848002221 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 271848002222 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 271848002223 type III secretion protein HrpB7; Region: HrpB7; TIGR02559 271848002224 type III secretion system ATPase; Provisional; Region: PRK09099 271848002225 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 271848002226 Walker A motif; other site 271848002227 ATP binding site [chemical binding]; other site 271848002228 Walker B motif; other site 271848002229 type III secretion system protein HrpB; Validated; Region: PRK09098 271848002230 type III secretion protein HrpB4; Region: HrpB4; TIGR02560 271848002231 Bacterial type III secretion protein (HrpB4); Region: HrpB4; pfam09502 271848002232 type III secretion apparatus lipoprotein, YscJ/HrcJ family; Region: III_secr_YscJ; TIGR02544 271848002233 Bacterial type III secretion protein (HrpB2); Region: HrpB2; pfam09487 271848002234 type III secretion protein HrpB1/HrpK; Region: HrpB1_HrpK; TIGR02561 271848002235 type III secretion system protein HrcU; Validated; Region: PRK09108 271848002236 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 271848002237 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 271848002238 FHIPEP family; Region: FHIPEP; pfam00771 271848002239 type III secretion protein HpaP; Region: HpaP; TIGR02557 271848002240 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 271848002241 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 271848002242 type III secretion system protein YscR; Provisional; Region: PRK12797 271848002243 Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794 271848002244 Tir chaperone protein (CesT) family; Region: CesT; cl08444 271848002245 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 271848002246 Bacterial type III secretion protein (HrpB1_HrpK); Region: HrpB1_HrpK; pfam09613 271848002247 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 271848002248 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848002249 Mg2+ binding site [ion binding]; other site 271848002250 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 271848002251 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848002252 active site 271848002253 phosphorylation site [posttranslational modification] 271848002254 intermolecular recognition site; other site 271848002255 dimerization interface [polypeptide binding]; other site 271848002256 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 271848002257 DNA binding site [nucleotide binding] 271848002258 type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516 271848002259 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 271848002260 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 271848002261 Walker A motif; other site 271848002262 ATP binding site [chemical binding]; other site 271848002263 Walker B motif; other site 271848002264 type IVB pilus formation outer membrane protein, R64 PilN family; Region: pilus_B_mal_scr; TIGR02520 271848002265 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 271848002266 Pilin accessory protein (PilO); Region: PAP_PilO; pfam06864 271848002267 type IV pilus biogenesis protein PilP; Region: pilP_fam; TIGR03021 271848002268 Type II/IV secretion system protein; Region: T2SE; pfam00437 271848002269 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 271848002270 Walker A motif; other site 271848002271 ATP binding site [chemical binding]; other site 271848002272 Walker B motif; other site 271848002273 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 271848002274 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 271848002275 PilS N terminal; Region: PilS; pfam08805 271848002276 PilM; Region: PilM; pfam07419 271848002277 Bacterial shufflon protein, N-terminal constant region; Region: Shufflon_N; pfam04917 271848002278 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 271848002279 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 271848002280 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 271848002281 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 271848002282 agmatinase; Region: agmatinase; TIGR01230 271848002283 oligomer interface [polypeptide binding]; other site 271848002284 putative active site [active] 271848002285 Mn binding site [ion binding]; other site 271848002286 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848002287 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848002288 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 271848002289 dimerization interface [polypeptide binding]; other site 271848002290 AAA domain; Region: AAA_32; pfam13654 271848002291 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 271848002292 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 271848002293 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 271848002294 non-specific DNA binding site [nucleotide binding]; other site 271848002295 salt bridge; other site 271848002296 sequence-specific DNA binding site [nucleotide binding]; other site 271848002297 cellulose synthase regulator protein; Provisional; Region: PRK11114 271848002298 endo-1,4-D-glucanase; Provisional; Region: PRK11097 271848002299 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 271848002300 cellulose biosynthesis protein BcsE; Region: cellulose_bcsE; TIGR03369 271848002301 cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371 271848002302 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 271848002303 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 271848002304 DXD motif; other site 271848002305 PilZ domain; Region: PilZ; pfam07238 271848002306 cellulose synthase operon protein YhjU; Region: cellulose_yhjU; TIGR03368 271848002307 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 271848002308 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 271848002309 active site 271848002310 iron coordination sites [ion binding]; other site 271848002311 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 271848002312 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 271848002313 substrate binding pocket [chemical binding]; other site 271848002314 membrane-bound complex binding site; other site 271848002315 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 271848002316 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 271848002317 Walker A/P-loop; other site 271848002318 ATP binding site [chemical binding]; other site 271848002319 Q-loop/lid; other site 271848002320 ABC transporter signature motif; other site 271848002321 Walker B; other site 271848002322 D-loop; other site 271848002323 H-loop/switch region; other site 271848002324 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 271848002325 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848002326 dimer interface [polypeptide binding]; other site 271848002327 conserved gate region; other site 271848002328 putative PBP binding loops; other site 271848002329 ABC-ATPase subunit interface; other site 271848002330 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 271848002331 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 271848002332 putative active site [active] 271848002333 putative FMN binding site [chemical binding]; other site 271848002334 putative substrate binding site [chemical binding]; other site 271848002335 putative catalytic residue [active] 271848002336 Autoinducer synthetase; Region: Autoind_synth; cl17404 271848002337 Autoinducer binding domain; Region: Autoind_bind; pfam03472 271848002338 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 271848002339 DNA binding residues [nucleotide binding] 271848002340 dimerization interface [polypeptide binding]; other site 271848002341 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859 271848002342 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 271848002343 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 271848002344 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 271848002345 putative hydrophobic ligand binding site [chemical binding]; other site 271848002346 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 271848002347 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 271848002348 putative DNA binding site [nucleotide binding]; other site 271848002349 putative Zn2+ binding site [ion binding]; other site 271848002350 AsnC family; Region: AsnC_trans_reg; pfam01037 271848002351 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 271848002352 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 271848002353 peptidase domain interface [polypeptide binding]; other site 271848002354 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 271848002355 active site 271848002356 catalytic triad [active] 271848002357 calcium binding site [ion binding]; other site 271848002358 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 271848002359 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 271848002360 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 271848002361 phosphate binding site [ion binding]; other site 271848002362 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848002363 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848002364 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 271848002365 dimerization interface [polypeptide binding]; other site 271848002366 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 271848002367 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848002368 putative substrate translocation pore; other site 271848002369 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 271848002370 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 271848002371 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 271848002372 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 271848002373 active site 271848002374 Zn binding site [ion binding]; other site 271848002375 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 271848002376 DNA binding site [nucleotide binding] 271848002377 Bacterial type III secretion apparatus protein (OrgA_MxiK); Region: OrgA_MxiK; cl09716 271848002378 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 271848002379 type III secretion system needle complex protein PrgJ; Provisional; Region: PRK15325 271848002380 Type III secretion needle MxiH like; Region: MxiH; cl09641 271848002381 type III secretion system protein PrgH/EprH; Region: PrgH; TIGR02554 271848002382 Type III secretion system protein PrgH-EprH (PrgH); Region: PrgH; pfam09480 271848002383 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 271848002384 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848002385 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 271848002386 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 271848002387 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 271848002388 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 271848002389 type III secretion regulator YopN/LcrE/InvE/MxiC; Region: LcrE; TIGR02568 271848002390 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 271848002391 type III secretion system protein InvA; Provisional; Region: PRK15337 271848002392 Invasion protein B family; Region: Invas_SpaK; cl04129 271848002393 ATP synthase SpaL; Validated; Region: PRK08149 271848002394 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 271848002395 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 271848002396 Walker A motif; other site 271848002397 ATP binding site [chemical binding]; other site 271848002398 Walker B motif; other site 271848002399 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 271848002400 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 271848002401 type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796 271848002402 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 271848002403 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 271848002404 type III secretion system protein SpaS; Validated; Region: PRK08156 271848002405 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 271848002406 Tetratricopeptide repeat; Region: TPR_3; pfam07720 271848002407 Tetratricopeptide repeat; Region: TPR_3; pfam07720 271848002408 Secretion system effector C (SseC) like family; Region: SseC; pfam04888 271848002409 type III secretion target, IpaC/SipC family; Region: IpaC_SipC; TIGR02101 271848002410 H-NS histone family; Region: Histone_HNS; pfam00816 271848002411 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 271848002412 type III effector protein IpaD/SipD/SspD; Region: SipD_IpaD_SspD; TIGR02553 271848002413 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848002414 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 271848002415 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 271848002416 N-acetyl-D-glucosamine binding site [chemical binding]; other site 271848002417 catalytic residue [active] 271848002418 type III secretion protein BopE; Provisional; Region: PRK15278 271848002419 SopE GEF domain; Region: SopE_GEF; pfam07487 271848002420 SicP binding; Region: SicP-binding; pfam09119 271848002421 chaperone protein SicP; Provisional; Region: PRK15329 271848002422 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 271848002423 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848002424 active site 271848002425 phosphorylation site [posttranslational modification] 271848002426 intermolecular recognition site; other site 271848002427 dimerization interface [polypeptide binding]; other site 271848002428 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 271848002429 DNA binding residues [nucleotide binding] 271848002430 dimerization interface [polypeptide binding]; other site 271848002431 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 271848002432 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848002433 Bacterial Ig-like domain; Region: Big_5; pfam13205 271848002434 Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly...; Region: Peptidase_C19; cl02553 271848002435 active site 271848002436 Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly...; Region: Peptidase_C19; cd02257 271848002437 active site 271848002438 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 271848002439 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 271848002440 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 271848002441 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 271848002442 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 271848002443 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 271848002444 Protein of unknown function (DUF3540); Region: DUF3540; pfam12059 271848002445 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 271848002446 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 271848002447 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 271848002448 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; cl02212 271848002449 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 271848002450 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 271848002451 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 271848002452 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 271848002453 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 271848002454 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 271848002455 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 271848002456 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848002457 Walker A motif; other site 271848002458 ATP binding site [chemical binding]; other site 271848002459 Walker B motif; other site 271848002460 arginine finger; other site 271848002461 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848002462 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 271848002463 Walker A motif; other site 271848002464 ATP binding site [chemical binding]; other site 271848002465 Walker B motif; other site 271848002466 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 271848002467 type VI secretion protein, VC_A0111 family; Region: VI_chp_1; TIGR03347 271848002468 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 271848002469 Bacterial protein of unknown function (DUF879); Region: DUF879; cl15462 271848002470 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 271848002471 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 271848002472 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 271848002473 Protein of unknown function (DUF877); Region: DUF877; pfam05943 271848002474 Protein of unknown function (DUF770); Region: DUF770; pfam05591 271848002475 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271848002476 dimer interface [polypeptide binding]; other site 271848002477 phosphorylation site [posttranslational modification] 271848002478 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848002479 ATP binding site [chemical binding]; other site 271848002480 G-X-G motif; other site 271848002481 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 271848002482 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848002483 active site 271848002484 phosphorylation site [posttranslational modification] 271848002485 intermolecular recognition site; other site 271848002486 dimerization interface [polypeptide binding]; other site 271848002487 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 271848002488 DNA binding site [nucleotide binding] 271848002489 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 271848002490 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 271848002491 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 271848002492 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 271848002493 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 271848002494 trimer interface [polypeptide binding]; other site 271848002495 Haemagglutinin; Region: HIM; pfam05662 271848002496 YadA-like C-terminal region; Region: YadA; pfam03895 271848002497 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 271848002498 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 271848002499 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 271848002500 amidase catalytic site [active] 271848002501 Zn binding residues [ion binding]; other site 271848002502 substrate binding site [chemical binding]; other site 271848002503 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 271848002504 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 271848002505 Haemagglutinin; Region: HIM; pfam05662 271848002506 YadA-like C-terminal region; Region: YadA; pfam03895 271848002507 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 271848002508 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 271848002509 Cu(I) binding site [ion binding]; other site 271848002510 Uncharacterized conserved protein [Function unknown]; Region: COG1262 271848002511 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 271848002512 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 271848002513 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 271848002514 Multicopper oxidase; Region: Cu-oxidase; pfam00394 271848002515 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 271848002516 Cytochrome c; Region: Cytochrom_C; pfam00034 271848002517 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 271848002518 putative hydrophobic ligand binding site [chemical binding]; other site 271848002519 protein interface [polypeptide binding]; other site 271848002520 gate; other site 271848002521 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 271848002522 hypothetical protein; Provisional; Region: PRK02399 271848002523 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 271848002524 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 271848002525 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 271848002526 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 271848002527 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 271848002528 homodimer interface [polypeptide binding]; other site 271848002529 NAD binding pocket [chemical binding]; other site 271848002530 ATP binding pocket [chemical binding]; other site 271848002531 Mg binding site [ion binding]; other site 271848002532 active-site loop [active] 271848002533 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 271848002534 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 271848002535 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 271848002536 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 271848002537 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 271848002538 putative active site [active] 271848002539 catalytic site [active] 271848002540 Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173 271848002541 putative active site [active] 271848002542 catalytic site [active] 271848002543 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 271848002544 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 271848002545 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 271848002546 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 271848002547 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 271848002548 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 271848002549 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848002550 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848002551 dimerization interface [polypeptide binding]; other site 271848002552 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 271848002553 aminotransferase A; Validated; Region: PRK07683 271848002554 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 271848002555 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848002556 homodimer interface [polypeptide binding]; other site 271848002557 catalytic residue [active] 271848002558 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 271848002559 aldehyde dehydrogenase family 7 member; Region: PLN02315 271848002560 tetrameric interface [polypeptide binding]; other site 271848002561 NAD binding site [chemical binding]; other site 271848002562 catalytic residues [active] 271848002563 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 271848002564 ApbE family; Region: ApbE; pfam02424 271848002565 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 271848002566 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 271848002567 Flavodoxin; Region: Flavodoxin_1; pfam00258 271848002568 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like2; cd06201 271848002569 FAD binding pocket [chemical binding]; other site 271848002570 FAD binding motif [chemical binding]; other site 271848002571 catalytic residues [active] 271848002572 NAD binding pocket [chemical binding]; other site 271848002573 phosphate binding motif [ion binding]; other site 271848002574 beta-alpha-beta structure motif; other site 271848002575 Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029 271848002576 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 271848002577 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 271848002578 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848002579 active site 271848002580 phosphorylation site [posttranslational modification] 271848002581 intermolecular recognition site; other site 271848002582 dimerization interface [polypeptide binding]; other site 271848002583 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 271848002584 DNA binding site [nucleotide binding] 271848002585 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 271848002586 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 271848002587 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271848002588 dimer interface [polypeptide binding]; other site 271848002589 phosphorylation site [posttranslational modification] 271848002590 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848002591 ATP binding site [chemical binding]; other site 271848002592 Mg2+ binding site [ion binding]; other site 271848002593 G-X-G motif; other site 271848002594 Transcriptional regulators [Transcription]; Region: PurR; COG1609 271848002595 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 271848002596 DNA binding site [nucleotide binding] 271848002597 domain linker motif; other site 271848002598 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_4; cd06280 271848002599 putative dimerization interface [polypeptide binding]; other site 271848002600 putative ligand binding site [chemical binding]; other site 271848002601 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 271848002602 active site 271848002603 phosphorylation site [posttranslational modification] 271848002604 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 271848002605 dimerization domain swap beta strand [polypeptide binding]; other site 271848002606 regulatory protein interface [polypeptide binding]; other site 271848002607 active site 271848002608 regulatory phosphorylation site [posttranslational modification]; other site 271848002609 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 271848002610 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 271848002611 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 271848002612 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 271848002613 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 271848002614 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 271848002615 putative substrate binding site [chemical binding]; other site 271848002616 putative ATP binding site [chemical binding]; other site 271848002617 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 271848002618 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 271848002619 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 271848002620 active site 271848002621 P-loop; other site 271848002622 phosphorylation site [posttranslational modification] 271848002623 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 271848002624 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 271848002625 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 271848002626 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 271848002627 benzoate transport; Region: 2A0115; TIGR00895 271848002628 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848002629 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848002630 putative substrate translocation pore; other site 271848002631 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 271848002632 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 271848002633 Methyltransferase domain; Region: Methyltransf_24; pfam13578 271848002634 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 271848002635 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 271848002636 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 271848002637 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 271848002638 ring oligomerisation interface [polypeptide binding]; other site 271848002639 ATP/Mg binding site [chemical binding]; other site 271848002640 stacking interactions; other site 271848002641 hinge regions; other site 271848002642 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 271848002643 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 271848002644 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 271848002645 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 271848002646 active site 271848002647 NAD synthetase; Reviewed; Region: nadE; PRK02628 271848002648 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 271848002649 multimer interface [polypeptide binding]; other site 271848002650 active site 271848002651 catalytic triad [active] 271848002652 protein interface 1 [polypeptide binding]; other site 271848002653 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 271848002654 homodimer interface [polypeptide binding]; other site 271848002655 NAD binding pocket [chemical binding]; other site 271848002656 ATP binding pocket [chemical binding]; other site 271848002657 Mg binding site [ion binding]; other site 271848002658 active-site loop [active] 271848002659 FOG: CBS domain [General function prediction only]; Region: COG0517 271848002660 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 271848002661 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 271848002662 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 271848002663 hexamer interface [polypeptide binding]; other site 271848002664 ligand binding site [chemical binding]; other site 271848002665 putative active site [active] 271848002666 NAD(P) binding site [chemical binding]; other site 271848002667 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 271848002668 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 271848002669 putative dimer interface [polypeptide binding]; other site 271848002670 Beta-lactamase; Region: Beta-lactamase; pfam00144 271848002671 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 271848002672 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 271848002673 Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200 271848002674 acetyl-CoA synthetase; Provisional; Region: PRK04319 271848002675 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 271848002676 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 271848002677 acyl-activating enzyme (AAE) consensus motif; other site 271848002678 AMP binding site [chemical binding]; other site 271848002679 active site 271848002680 CoA binding site [chemical binding]; other site 271848002681 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 271848002682 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 271848002683 tetramer interface [polypeptide binding]; other site 271848002684 TPP-binding site [chemical binding]; other site 271848002685 heterodimer interface [polypeptide binding]; other site 271848002686 phosphorylation loop region [posttranslational modification] 271848002687 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 271848002688 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 271848002689 alpha subunit interface [polypeptide binding]; other site 271848002690 TPP binding site [chemical binding]; other site 271848002691 heterodimer interface [polypeptide binding]; other site 271848002692 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 271848002693 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 271848002694 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 271848002695 E3 interaction surface; other site 271848002696 lipoyl attachment site [posttranslational modification]; other site 271848002697 e3 binding domain; Region: E3_binding; pfam02817 271848002698 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 271848002699 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848002700 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 271848002701 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 271848002702 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 271848002703 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 271848002704 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 271848002705 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 271848002706 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 271848002707 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 271848002708 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 271848002709 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 271848002710 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 271848002711 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 271848002712 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 271848002713 active site 271848002714 catalytic site [active] 271848002715 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 271848002716 glycogen branching enzyme; Provisional; Region: PRK05402 271848002717 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 271848002718 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 271848002719 active site 271848002720 catalytic site [active] 271848002721 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 271848002722 glycogen synthase; Provisional; Region: glgA; PRK00654 271848002723 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 271848002724 ADP-binding pocket [chemical binding]; other site 271848002725 homodimer interface [polypeptide binding]; other site 271848002726 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 271848002727 putative homodimer interface [polypeptide binding]; other site 271848002728 putative active site pocket [active] 271848002729 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 271848002730 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 271848002731 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 271848002732 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 271848002733 acyl-activating enzyme (AAE) consensus motif; other site 271848002734 active site 271848002735 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 271848002736 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 271848002737 putative acyl-acceptor binding pocket; other site 271848002738 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 271848002739 Multicopper oxidase; Region: Cu-oxidase; pfam00394 271848002740 Cytochrome c; Region: Cytochrom_C; pfam00034 271848002741 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 271848002742 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 271848002743 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 271848002744 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 271848002745 isovaleryl-CoA dehydrogenase; Region: PLN02519 271848002746 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 271848002747 substrate binding site [chemical binding]; other site 271848002748 FAD binding site [chemical binding]; other site 271848002749 catalytic base [active] 271848002750 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 271848002751 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 271848002752 enoyl-CoA hydratase; Provisional; Region: PRK05995 271848002753 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 271848002754 substrate binding site [chemical binding]; other site 271848002755 oxyanion hole (OAH) forming residues; other site 271848002756 trimer interface [polypeptide binding]; other site 271848002757 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 271848002758 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 271848002759 ATP-grasp domain; Region: ATP-grasp_4; cl17255 271848002760 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 271848002761 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 271848002762 carboxyltransferase (CT) interaction site; other site 271848002763 biotinylation site [posttranslational modification]; other site 271848002764 Protein of unknown function (DUF2827); Region: DUF2827; pfam10933 271848002765 Protein of unknown function (DUF2827); Region: DUF2827; pfam10933 271848002766 Protein of unknown function (DUF2827); Region: DUF2827; pfam10933 271848002767 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 271848002768 TPR motif; other site 271848002769 binding surface 271848002770 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 271848002771 binding surface 271848002772 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 271848002773 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 271848002774 Haemagglutinin; Region: HIM; pfam05662 271848002775 YadA-like C-terminal region; Region: YadA; pfam03895 271848002776 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 271848002777 arsenical-resistance protein; Region: acr3; TIGR00832 271848002778 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 271848002779 Low molecular weight phosphatase family; Region: LMWPc; cd00115 271848002780 active site 271848002781 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 271848002782 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 271848002783 putative metal binding site [ion binding]; other site 271848002784 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 271848002785 dimerization interface [polypeptide binding]; other site 271848002786 putative DNA binding site [nucleotide binding]; other site 271848002787 putative Zn2+ binding site [ion binding]; other site 271848002788 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 271848002789 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 271848002790 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 271848002791 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 271848002792 Walker A/P-loop; other site 271848002793 ATP binding site [chemical binding]; other site 271848002794 Q-loop/lid; other site 271848002795 ABC transporter signature motif; other site 271848002796 Walker B; other site 271848002797 D-loop; other site 271848002798 H-loop/switch region; other site 271848002799 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 271848002800 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848002801 dimer interface [polypeptide binding]; other site 271848002802 conserved gate region; other site 271848002803 putative PBP binding loops; other site 271848002804 ABC-ATPase subunit interface; other site 271848002805 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 271848002806 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 271848002807 conserved cys residue [active] 271848002808 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848002809 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 271848002810 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 271848002811 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 271848002812 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 271848002813 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 271848002814 putative NAD(P) binding site [chemical binding]; other site 271848002815 active site 271848002816 putative substrate binding site [chemical binding]; other site 271848002817 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 271848002818 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848002819 D-galactonate transporter; Region: 2A0114; TIGR00893 271848002820 putative substrate translocation pore; other site 271848002821 putative aldolase; Validated; Region: PRK08130 271848002822 intersubunit interface [polypeptide binding]; other site 271848002823 active site 271848002824 Zn2+ binding site [ion binding]; other site 271848002825 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 271848002826 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 271848002827 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 271848002828 NAD binding site [chemical binding]; other site 271848002829 Transcriptional regulators [Transcription]; Region: FadR; COG2186 271848002830 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 271848002831 DNA-binding site [nucleotide binding]; DNA binding site 271848002832 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 271848002833 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 271848002834 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 271848002835 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 271848002836 DNA binding residues [nucleotide binding] 271848002837 putative dimer interface [polypeptide binding]; other site 271848002838 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 271848002839 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 271848002840 Leucine carboxyl methyltransferase; Region: LCM; cl01306 271848002841 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 271848002842 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 271848002843 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 271848002844 active site 271848002845 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167 271848002846 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 271848002847 putative ligand binding site [chemical binding]; other site 271848002848 putative NAD binding site [chemical binding]; other site 271848002849 catalytic site [active] 271848002850 Transcriptional regulators [Transcription]; Region: PurR; COG1609 271848002851 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 271848002852 DNA binding site [nucleotide binding] 271848002853 domain linker motif; other site 271848002854 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 271848002855 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 271848002856 DctM-like transporters; Region: DctM; pfam06808 271848002857 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 271848002858 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 271848002859 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 271848002860 GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039 271848002861 glutathione s-transferase; Provisional; Region: PTZ00057 271848002862 GSH binding site (G-site) [chemical binding]; other site 271848002863 C-terminal domain interface [polypeptide binding]; other site 271848002864 dimer interface [polypeptide binding]; other site 271848002865 C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases; Region: GST_C_Sigma_like; cd03192 271848002866 dimer interface [polypeptide binding]; other site 271848002867 N-terminal domain interface [polypeptide binding]; other site 271848002868 substrate binding pocket (H-site) [chemical binding]; other site 271848002869 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 271848002870 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 271848002871 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 271848002872 hypothetical protein; Provisional; Region: PRK11239 271848002873 Protein of unknown function, DUF480; Region: DUF480; pfam04337 271848002874 Helix-turn-helix domain; Region: HTH_18; pfam12833 271848002875 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848002876 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 271848002877 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 271848002878 conserved cys residue [active] 271848002879 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848002880 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 271848002881 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 271848002882 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 271848002883 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 271848002884 hydroxyglutarate oxidase; Provisional; Region: PRK11728 271848002885 Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311 271848002886 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 271848002887 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 271848002888 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 271848002889 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 271848002890 Sarcosine oxidase gamma subunit [Amino acid transport and metabolism]; Region: COG4583 271848002891 Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539 271848002892 active site 271848002893 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 271848002894 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 271848002895 DNA-binding site [nucleotide binding]; DNA binding site 271848002896 RNA-binding motif; other site 271848002897 Protein of unknown function (DUF3761); Region: DUF3761; pfam12587 271848002898 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 271848002899 OsmC-like protein; Region: OsmC; cl00767 271848002900 CHASE3 domain; Region: CHASE3; pfam05227 271848002901 PAS fold; Region: PAS; pfam00989 271848002902 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271848002903 putative active site [active] 271848002904 heme pocket [chemical binding]; other site 271848002905 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 271848002906 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271848002907 putative active site [active] 271848002908 heme pocket [chemical binding]; other site 271848002909 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271848002910 dimer interface [polypeptide binding]; other site 271848002911 phosphorylation site [posttranslational modification] 271848002912 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848002913 ATP binding site [chemical binding]; other site 271848002914 Mg2+ binding site [ion binding]; other site 271848002915 G-X-G motif; other site 271848002916 Response regulator receiver domain; Region: Response_reg; pfam00072 271848002917 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848002918 active site 271848002919 phosphorylation site [posttranslational modification] 271848002920 intermolecular recognition site; other site 271848002921 dimerization interface [polypeptide binding]; other site 271848002922 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848002923 Response regulator receiver domain; Region: Response_reg; pfam00072 271848002924 active site 271848002925 phosphorylation site [posttranslational modification] 271848002926 intermolecular recognition site; other site 271848002927 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271848002928 PAS fold; Region: PAS_3; pfam08447 271848002929 putative active site [active] 271848002930 heme pocket [chemical binding]; other site 271848002931 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 271848002932 Histidine kinase; Region: HisKA_3; pfam07730 271848002933 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848002934 ATP binding site [chemical binding]; other site 271848002935 Mg2+ binding site [ion binding]; other site 271848002936 G-X-G motif; other site 271848002937 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848002938 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848002939 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 271848002940 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 271848002941 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 271848002942 active site 271848002943 DNA binding site [nucleotide binding] 271848002944 Int/Topo IB signature motif; other site 271848002945 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 271848002946 SPFH domain / Band 7 family; Region: Band_7; pfam01145 271848002947 Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892 271848002948 DNA methylase; Region: N6_N4_Mtase; pfam01555 271848002949 DNA methylase; Region: N6_N4_Mtase; pfam01555 271848002950 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 271848002951 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 271848002952 Active Sites [active] 271848002953 PRTRC system ParB family protein; Region: PRTRC_parB; TIGR03734 271848002954 Helix-turn-helix domain; Region: HTH_36; pfam13730 271848002955 Helix-turn-helix domain; Region: HTH_36; pfam13730 271848002956 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 271848002957 Protein of unknown function (DUF497); Region: DUF497; pfam04365 271848002958 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 271848002959 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 271848002960 Phage-related protein [Function unknown]; Region: COG4695; cl01923 271848002961 Phage portal protein; Region: Phage_portal; pfam04860 271848002962 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 271848002963 oligomer interface [polypeptide binding]; other site 271848002964 active site residues [active] 271848002965 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 271848002966 Phage capsid family; Region: Phage_capsid; pfam05065 271848002967 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 271848002968 oligomerization interface [polypeptide binding]; other site 271848002969 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 271848002970 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 271848002971 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 271848002972 Phage tail assembly chaperone; Region: Phage_TAC; pfam06222 271848002973 Protein of unknown function (DUF4035); Region: DUF4035; pfam13227 271848002974 tape measure domain; Region: tape_meas_nterm; TIGR02675 271848002975 phage tail tape measure protein, lambda family; Region: tape_meas_lam_C; TIGR01541 271848002976 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 271848002977 Phage minor tail protein; Region: Phage_min_tail; pfam05939 271848002978 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 271848002979 Phage-related protein [Function unknown]; Region: gp18; COG4672 271848002980 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 271848002981 MPN+ (JAMM) motif; other site 271848002982 Zinc-binding site [ion binding]; other site 271848002983 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 271848002984 NlpC/P60 family; Region: NLPC_P60; cl17555 271848002985 Phage-related protein, tail component [Function unknown]; Region: COG4723 271848002986 Phage-related protein, tail component [Function unknown]; Region: COG4733 271848002987 Putative phage tail protein; Region: Phage-tail_3; pfam13550 271848002988 Fibronectin type 3 domain; Region: FN3; smart00060 271848002989 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 271848002990 Phage holin family 2; Region: Phage_holin_2; pfam04550 271848002991 Peptidase M15; Region: Peptidase_M15_3; cl01194 271848002992 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 271848002993 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848002994 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 271848002995 choline dehydrogenase; Validated; Region: PRK02106 271848002996 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 271848002997 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 271848002998 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 271848002999 tetrameric interface [polypeptide binding]; other site 271848003000 NAD binding site [chemical binding]; other site 271848003001 catalytic residues [active] 271848003002 transcriptional regulator BetI; Validated; Region: PRK00767 271848003003 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 271848003004 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 271848003005 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 271848003006 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 271848003007 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 271848003008 active site 271848003009 TDP-binding site; other site 271848003010 acceptor substrate-binding pocket; other site 271848003011 homodimer interface [polypeptide binding]; other site 271848003012 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 271848003013 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848003014 putative substrate translocation pore; other site 271848003015 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848003016 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 271848003017 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 271848003018 Ligand binding site; other site 271848003019 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 271848003020 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 271848003021 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 271848003022 HlyD family secretion protein; Region: HlyD_3; pfam13437 271848003023 Transposase, Mutator family; Region: Transposase_mut; pfam00872 271848003024 MULE transposase domain; Region: MULE; pfam10551 271848003025 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 271848003026 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 271848003027 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 271848003028 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 271848003029 dimerization interface [polypeptide binding]; other site 271848003030 putative DNA binding site [nucleotide binding]; other site 271848003031 putative Zn2+ binding site [ion binding]; other site 271848003032 Predicted transporter component [General function prediction only]; Region: COG2391 271848003033 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 271848003034 Predicted transporter component [General function prediction only]; Region: COG2391 271848003035 Sulphur transport; Region: Sulf_transp; pfam04143 271848003036 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 271848003037 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 271848003038 Coenzyme A binding pocket [chemical binding]; other site 271848003039 Protein of unknown function (DUF3079); Region: DUF3079; pfam11278 271848003040 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 271848003041 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 271848003042 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 271848003043 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 271848003044 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 271848003045 active site 271848003046 metal binding site [ion binding]; metal-binding site 271848003047 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 271848003048 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 271848003049 active site 271848003050 benzoate transport; Region: 2A0115; TIGR00895 271848003051 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848003052 putative substrate translocation pore; other site 271848003053 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 271848003054 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 271848003055 DNA-binding site [nucleotide binding]; DNA binding site 271848003056 UTRA domain; Region: UTRA; pfam07702 271848003057 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 271848003058 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848003059 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 271848003060 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 271848003061 motif II; other site 271848003062 LabA_like proteins; Region: LabA_like; cd06167 271848003063 putative metal binding site [ion binding]; other site 271848003064 Uncharacterized conserved protein [Function unknown]; Region: COG1432 271848003065 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 271848003066 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 271848003067 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 271848003068 putative DNA binding site [nucleotide binding]; other site 271848003069 putative Zn2+ binding site [ion binding]; other site 271848003070 AsnC family; Region: AsnC_trans_reg; pfam01037 271848003071 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 271848003072 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 271848003073 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848003074 catalytic residue [active] 271848003075 Phosphoesterase family; Region: Phosphoesterase; pfam04185 271848003076 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 271848003077 Beta-lactamase; Region: Beta-lactamase; pfam00144 271848003078 BCCT family transporter; Region: BCCT; pfam02028 271848003079 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 271848003080 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 271848003081 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 271848003082 putative active site [active] 271848003083 Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked...; Region: Ntn_Asparaginase_2_like; cl00635 271848003084 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 271848003085 catalytic nucleophile [active] 271848003086 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 271848003087 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 271848003088 Walker A/P-loop; other site 271848003089 ATP binding site [chemical binding]; other site 271848003090 Q-loop/lid; other site 271848003091 ABC transporter signature motif; other site 271848003092 Walker B; other site 271848003093 D-loop; other site 271848003094 H-loop/switch region; other site 271848003095 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 271848003096 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 271848003097 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 271848003098 Walker A/P-loop; other site 271848003099 ATP binding site [chemical binding]; other site 271848003100 Q-loop/lid; other site 271848003101 ABC transporter signature motif; other site 271848003102 Walker B; other site 271848003103 D-loop; other site 271848003104 H-loop/switch region; other site 271848003105 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 271848003106 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 271848003107 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 271848003108 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 271848003109 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848003110 dimer interface [polypeptide binding]; other site 271848003111 conserved gate region; other site 271848003112 putative PBP binding loops; other site 271848003113 ABC-ATPase subunit interface; other site 271848003114 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 271848003115 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 271848003116 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848003117 dimer interface [polypeptide binding]; other site 271848003118 conserved gate region; other site 271848003119 putative PBP binding loops; other site 271848003120 ABC-ATPase subunit interface; other site 271848003121 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 271848003122 homotetramer interface [polypeptide binding]; other site 271848003123 DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group represents...; Region: DmpA_OAT; cl00603 271848003124 cleavage site 271848003125 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 271848003126 SxDxEG motif; other site 271848003127 active site 271848003128 metal binding site [ion binding]; metal-binding site 271848003129 homopentamer interface [polypeptide binding]; other site 271848003130 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 271848003131 active site 271848003132 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 271848003133 heterodimer interface [polypeptide binding]; other site 271848003134 multimer interface [polypeptide binding]; other site 271848003135 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 271848003136 active site 271848003137 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 271848003138 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848003139 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848003140 dimerization interface [polypeptide binding]; other site 271848003141 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271848003142 metal binding site [ion binding]; metal-binding site 271848003143 active site 271848003144 I-site; other site 271848003145 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 271848003146 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848003147 S-adenosylmethionine binding site [chemical binding]; other site 271848003148 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 271848003149 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 271848003150 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 271848003151 Cache domain; Region: Cache_1; pfam02743 271848003152 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 271848003153 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271848003154 metal binding site [ion binding]; metal-binding site 271848003155 active site 271848003156 I-site; other site 271848003157 putative transporter; Provisional; Region: PRK11021 271848003158 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 271848003159 CRISPR-associated helicase Cas3, subtype CYANO; Region: cas3_cyano; TIGR03158 271848003160 ATP binding site [chemical binding]; other site 271848003161 putative Mg++ binding site [ion binding]; other site 271848003162 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 271848003163 nucleotide binding region [chemical binding]; other site 271848003164 ATP-binding site [chemical binding]; other site 271848003165 DEAD/H associated; Region: DEAD_assoc; pfam08494 271848003166 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 271848003167 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 271848003168 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 271848003169 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 271848003170 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 271848003171 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 271848003172 putative active site [active] 271848003173 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 271848003174 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 271848003175 Walker A/P-loop; other site 271848003176 ATP binding site [chemical binding]; other site 271848003177 Q-loop/lid; other site 271848003178 ABC transporter signature motif; other site 271848003179 Walker B; other site 271848003180 D-loop; other site 271848003181 H-loop/switch region; other site 271848003182 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 271848003183 putative acyl-acceptor binding pocket; other site 271848003184 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 271848003185 linker region; other site 271848003186 HlyD family secretion protein; Region: HlyD_3; pfam13437 271848003187 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 271848003188 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 271848003189 threonine dehydratase; Reviewed; Region: PRK09224 271848003190 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 271848003191 tetramer interface [polypeptide binding]; other site 271848003192 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848003193 catalytic residue [active] 271848003194 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 271848003195 putative Ile/Val binding site [chemical binding]; other site 271848003196 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 271848003197 putative Ile/Val binding site [chemical binding]; other site 271848003198 EamA-like transporter family; Region: EamA; pfam00892 271848003199 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 271848003200 Uncharacterized conserved protein [Function unknown]; Region: COG1739 271848003201 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 271848003202 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 271848003203 Protein of unknown function (DUF2894); Region: DUF2894; pfam11445 271848003204 Protein of unknown function (DUF2894); Region: DUF2894; pfam11445 271848003205 hypothetical protein; Provisional; Region: PRK09040 271848003206 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 271848003207 ligand binding site [chemical binding]; other site 271848003208 Domain of unknown function (DUF802); Region: DUF802; pfam05650 271848003209 Domain of unknown function (DUF802); Region: DUF802; pfam05650 271848003210 Protein of unknown function (DUF3348); Region: DUF3348; pfam11828 271848003211 Uncharacterized protein conserved in bacteria (DUF2322); Region: DUF2322; pfam10084 271848003212 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 271848003213 CoA-transferase family III; Region: CoA_transf_3; pfam02515 271848003214 short chain dehydrogenase; Provisional; Region: PRK12937 271848003215 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 271848003216 NADP binding site [chemical binding]; other site 271848003217 homodimer interface [polypeptide binding]; other site 271848003218 active site 271848003219 substrate binding site [chemical binding]; other site 271848003220 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848003221 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848003222 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848003223 dimerization interface [polypeptide binding]; other site 271848003224 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 271848003225 aspartate racemase; Region: asp_race; TIGR00035 271848003226 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848003227 transcriptional activator TtdR; Provisional; Region: PRK09801 271848003228 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 271848003229 putative effector binding pocket; other site 271848003230 dimerization interface [polypeptide binding]; other site 271848003231 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 271848003232 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 271848003233 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 271848003234 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 271848003235 putative NAD(P) binding site [chemical binding]; other site 271848003236 dimer interface [polypeptide binding]; other site 271848003237 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848003238 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848003239 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 271848003240 dimerization interface [polypeptide binding]; other site 271848003241 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848003242 metabolite-proton symporter; Region: 2A0106; TIGR00883 271848003243 putative substrate translocation pore; other site 271848003244 allantoate amidohydrolase; Reviewed; Region: PRK12893 271848003245 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 271848003246 active site 271848003247 metal binding site [ion binding]; metal-binding site 271848003248 dimer interface [polypeptide binding]; other site 271848003249 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 271848003250 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 271848003251 active site 271848003252 Zn binding site [ion binding]; other site 271848003253 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 271848003254 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 271848003255 NMT1-like family; Region: NMT1_2; pfam13379 271848003256 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 271848003257 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848003258 active site 271848003259 phosphorylation site [posttranslational modification] 271848003260 intermolecular recognition site; other site 271848003261 dimerization interface [polypeptide binding]; other site 271848003262 ANTAR domain; Region: ANTAR; pfam03861 271848003263 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 271848003264 active site 271848003265 SAM binding site [chemical binding]; other site 271848003266 homodimer interface [polypeptide binding]; other site 271848003267 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 271848003268 nitrite reductase subunit NirD; Provisional; Region: PRK14989 271848003269 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 271848003270 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 271848003271 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 271848003272 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 271848003273 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 271848003274 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 271848003275 [4Fe-4S] binding site [ion binding]; other site 271848003276 molybdopterin cofactor binding site; other site 271848003277 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 271848003278 molybdopterin cofactor binding site; other site 271848003279 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 271848003280 Flavodoxin; Region: Flavodoxin_1; pfam00258 271848003281 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 271848003282 FAD binding pocket [chemical binding]; other site 271848003283 FAD binding motif [chemical binding]; other site 271848003284 catalytic residues [active] 271848003285 NAD binding pocket [chemical binding]; other site 271848003286 phosphate binding motif [ion binding]; other site 271848003287 beta-alpha-beta structure motif; other site 271848003288 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 271848003289 N- and C-terminal domain interface [polypeptide binding]; other site 271848003290 active site 271848003291 MgATP binding site [chemical binding]; other site 271848003292 catalytic site [active] 271848003293 metal binding site [ion binding]; metal-binding site 271848003294 xylulose binding site [chemical binding]; other site 271848003295 homodimer interface [polypeptide binding]; other site 271848003296 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 271848003297 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848003298 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848003299 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 271848003300 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 271848003301 Walker A/P-loop; other site 271848003302 ATP binding site [chemical binding]; other site 271848003303 Q-loop/lid; other site 271848003304 ABC transporter signature motif; other site 271848003305 Walker B; other site 271848003306 D-loop; other site 271848003307 H-loop/switch region; other site 271848003308 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 271848003309 L-idonate 5-dehydrogenase; Region: PLN02702 271848003310 inhibitor binding site; inhibition site 271848003311 catalytic Zn binding site [ion binding]; other site 271848003312 structural Zn binding site [ion binding]; other site 271848003313 NADP binding site [chemical binding]; other site 271848003314 tetramer interface [polypeptide binding]; other site 271848003315 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 271848003316 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848003317 dimer interface [polypeptide binding]; other site 271848003318 conserved gate region; other site 271848003319 putative PBP binding loops; other site 271848003320 ABC-ATPase subunit interface; other site 271848003321 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 271848003322 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 271848003323 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 271848003324 Electron transfer DM13; Region: DM13; pfam10517 271848003325 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 271848003326 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 271848003327 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 271848003328 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 271848003329 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 271848003330 active site 271848003331 LssY C-terminus; Region: LssY_C; pfam14067 271848003332 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 271848003333 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 271848003334 Outer membrane efflux protein; Region: OEP; pfam02321 271848003335 Outer membrane efflux protein; Region: OEP; pfam02321 271848003336 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 271848003337 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 271848003338 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271848003339 dimer interface [polypeptide binding]; other site 271848003340 phosphorylation site [posttranslational modification] 271848003341 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848003342 ATP binding site [chemical binding]; other site 271848003343 Mg2+ binding site [ion binding]; other site 271848003344 G-X-G motif; other site 271848003345 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 271848003346 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848003347 active site 271848003348 phosphorylation site [posttranslational modification] 271848003349 intermolecular recognition site; other site 271848003350 dimerization interface [polypeptide binding]; other site 271848003351 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 271848003352 DNA binding site [nucleotide binding] 271848003353 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 271848003354 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 271848003355 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 271848003356 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 271848003357 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 271848003358 putative cation:proton antiport protein; Provisional; Region: PRK10669 271848003359 TrkA-N domain; Region: TrkA_N; pfam02254 271848003360 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848003361 short chain dehydrogenase; Provisional; Region: PRK07074 271848003362 NAD(P) binding site [chemical binding]; other site 271848003363 active site 271848003364 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 271848003365 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 271848003366 ligand binding site [chemical binding]; other site 271848003367 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 271848003368 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 271848003369 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 271848003370 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 271848003371 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 271848003372 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 271848003373 dimer interface [polypeptide binding]; other site 271848003374 putative CheW interface [polypeptide binding]; other site 271848003375 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 271848003376 Isochorismatase family; Region: Isochorismatase; pfam00857 271848003377 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 271848003378 catalytic triad [active] 271848003379 conserved cis-peptide bond; other site 271848003380 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 271848003381 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 271848003382 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 271848003383 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 271848003384 N-terminal plug; other site 271848003385 ligand-binding site [chemical binding]; other site 271848003386 aspartate carbamoyltransferase; Provisional; Region: PRK11891 271848003387 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 271848003388 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 271848003389 Predicted small secreted protein [Function unknown]; Region: COG5510 271848003390 Cupin domain; Region: Cupin_2; cl17218 271848003391 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 271848003392 Uncharacterized conserved protein [Function unknown]; Region: COG2128 271848003393 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 271848003394 DNA-binding site [nucleotide binding]; DNA binding site 271848003395 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 271848003396 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 271848003397 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848003398 homodimer interface [polypeptide binding]; other site 271848003399 catalytic residue [active] 271848003400 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349; Region: Frankia_peptide; pfam14407 271848003401 major capsid protein; Region: PHA00665 271848003402 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 271848003403 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 271848003404 active site 271848003405 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 271848003406 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 271848003407 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 271848003408 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 271848003409 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 271848003410 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 271848003411 catalytic residue [active] 271848003412 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 271848003413 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 271848003414 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 271848003415 acyl-activating enzyme (AAE) consensus motif; other site 271848003416 AMP binding site [chemical binding]; other site 271848003417 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 271848003418 Condensation domain; Region: Condensation; pfam00668 271848003419 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 271848003420 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 271848003421 Condensation domain; Region: Condensation; pfam00668 271848003422 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 271848003423 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 271848003424 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 271848003425 acyl-activating enzyme (AAE) consensus motif; other site 271848003426 AMP binding site [chemical binding]; other site 271848003427 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 271848003428 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 271848003429 Condensation domain; Region: Condensation; pfam00668 271848003430 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 271848003431 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 271848003432 acyl-activating enzyme (AAE) consensus motif; other site 271848003433 AMP binding site [chemical binding]; other site 271848003434 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 271848003435 Condensation domain; Region: Condensation; pfam00668 271848003436 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 271848003437 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 271848003438 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 271848003439 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 271848003440 catalytic residue [active] 271848003441 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 271848003442 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 271848003443 acyl-CoA synthetase; Validated; Region: PRK05850 271848003444 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 271848003445 acyl-activating enzyme (AAE) consensus motif; other site 271848003446 active site 271848003447 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 271848003448 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 271848003449 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 271848003450 Bacterial transcriptional regulator; Region: IclR; pfam01614 271848003451 shikimate transporter; Provisional; Region: PRK09952 271848003452 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848003453 putative substrate translocation pore; other site 271848003454 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 271848003455 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 271848003456 dimer interface [polypeptide binding]; other site 271848003457 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 271848003458 active site 271848003459 Fe binding site [ion binding]; other site 271848003460 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 271848003461 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 271848003462 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 271848003463 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 271848003464 acyl-activating enzyme (AAE) consensus motif; other site 271848003465 AMP binding site [chemical binding]; other site 271848003466 Autoinducer synthetase; Region: Autoind_synth; cl17404 271848003467 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 271848003468 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 271848003469 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 271848003470 Autoinducer binding domain; Region: Autoind_bind; pfam03472 271848003471 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 271848003472 DNA binding residues [nucleotide binding] 271848003473 dimerization interface [polypeptide binding]; other site 271848003474 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 271848003475 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 271848003476 active site 271848003477 Zn binding site [ion binding]; other site 271848003478 Condensation domain; Region: Condensation; pfam00668 271848003479 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 271848003480 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 271848003481 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 271848003482 acyl-activating enzyme (AAE) consensus motif; other site 271848003483 AMP binding site [chemical binding]; other site 271848003484 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 271848003485 Condensation domain; Region: Condensation; pfam00668 271848003486 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 271848003487 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 271848003488 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 271848003489 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 271848003490 active site 271848003491 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 271848003492 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 271848003493 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848003494 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 271848003495 NAD(P) binding site [chemical binding]; other site 271848003496 active site 271848003497 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 271848003498 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 271848003499 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 271848003500 active site 271848003501 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 271848003502 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 271848003503 putative NADP binding site [chemical binding]; other site 271848003504 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848003505 NAD(P) binding site [chemical binding]; other site 271848003506 active site 271848003507 active site 271848003508 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 271848003509 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115 271848003510 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 271848003511 acyl-activating enzyme (AAE) consensus motif; other site 271848003512 AMP binding site [chemical binding]; other site 271848003513 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 271848003514 Condensation domain; Region: Condensation; pfam00668 271848003515 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 271848003516 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 271848003517 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 271848003518 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 271848003519 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 271848003520 active site 271848003521 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 271848003522 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 271848003523 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 271848003524 Predicted membrane protein (DUF2070); Region: DUF2070; pfam09843 271848003525 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 271848003526 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 271848003527 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848003528 putative substrate translocation pore; other site 271848003529 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 271848003530 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 271848003531 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 271848003532 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 271848003533 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 271848003534 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 271848003535 ligand binding site [chemical binding]; other site 271848003536 flexible hinge region; other site 271848003537 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 271848003538 putative switch regulator; other site 271848003539 non-specific DNA interactions [nucleotide binding]; other site 271848003540 DNA binding site [nucleotide binding] 271848003541 sequence specific DNA binding site [nucleotide binding]; other site 271848003542 putative cAMP binding site [chemical binding]; other site 271848003543 Response regulator receiver domain; Region: Response_reg; pfam00072 271848003544 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848003545 active site 271848003546 phosphorylation site [posttranslational modification] 271848003547 intermolecular recognition site; other site 271848003548 dimerization interface [polypeptide binding]; other site 271848003549 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 271848003550 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848003551 active site 271848003552 phosphorylation site [posttranslational modification] 271848003553 intermolecular recognition site; other site 271848003554 dimerization interface [polypeptide binding]; other site 271848003555 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 271848003556 DNA binding residues [nucleotide binding] 271848003557 dimerization interface [polypeptide binding]; other site 271848003558 CHASE domain; Region: CHASE; cl01369 271848003559 PAS domain S-box; Region: sensory_box; TIGR00229 271848003560 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271848003561 putative active site [active] 271848003562 heme pocket [chemical binding]; other site 271848003563 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 271848003564 Histidine kinase; Region: HisKA_3; pfam07730 271848003565 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848003566 ATP binding site [chemical binding]; other site 271848003567 Mg2+ binding site [ion binding]; other site 271848003568 G-X-G motif; other site 271848003569 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 271848003570 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 271848003571 [4Fe-4S] binding site [ion binding]; other site 271848003572 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 271848003573 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 271848003574 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 271848003575 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 271848003576 molybdopterin cofactor binding site; other site 271848003577 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 271848003578 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 271848003579 4Fe-4S binding domain; Region: Fer4; cl02805 271848003580 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 271848003581 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 271848003582 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 271848003583 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 271848003584 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848003585 putative substrate translocation pore; other site 271848003586 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 271848003587 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848003588 S-adenosylmethionine binding site [chemical binding]; other site 271848003589 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 271848003590 regulatory phosphorylation site [posttranslational modification]; other site 271848003591 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 271848003592 hydrogenase 4 subunit B; Validated; Region: PRK06521 271848003593 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 271848003594 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 271848003595 NADH dehydrogenase; Region: NADHdh; cl00469 271848003596 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899 271848003597 hydrogenase 4 subunit F; Validated; Region: PRK06458 271848003598 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 271848003599 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 271848003600 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 271848003601 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 271848003602 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 271848003603 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 271848003604 Ligand Binding Site [chemical binding]; other site 271848003605 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 271848003606 Ligand Binding Site [chemical binding]; other site 271848003607 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 271848003608 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 271848003609 ATP binding site [chemical binding]; other site 271848003610 Predicted transcriptional regulators [Transcription]; Region: COG1695 271848003611 Transcriptional regulator PadR-like family; Region: PadR; cl17335 271848003612 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 271848003613 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 271848003614 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 271848003615 active site 271848003616 FMN binding site [chemical binding]; other site 271848003617 2,4-decadienoyl-CoA binding site; other site 271848003618 catalytic residue [active] 271848003619 4Fe-4S cluster binding site [ion binding]; other site 271848003620 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 271848003621 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 271848003622 SnoaL-like domain; Region: SnoaL_2; pfam12680 271848003623 PAS fold; Region: PAS_4; pfam08448 271848003624 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 271848003625 DNA binding residues [nucleotide binding] 271848003626 dimerization interface [polypeptide binding]; other site 271848003627 Predicted small integral membrane protein (DUF2165); Region: DUF2165; cl02290 271848003628 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848003629 putative substrate translocation pore; other site 271848003630 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 271848003631 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 271848003632 active site 271848003633 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 271848003634 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848003635 S-adenosylmethionine binding site [chemical binding]; other site 271848003636 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 271848003637 catalytic motif [active] 271848003638 Zn binding site [ion binding]; other site 271848003639 Uncharacterized conserved protein [Function unknown]; Region: COG1262 271848003640 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 271848003641 Methyltransferase domain; Region: Methyltransf_23; pfam13489 271848003642 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848003643 S-adenosylmethionine binding site [chemical binding]; other site 271848003644 FOG: WD40 repeat [General function prediction only]; Region: COG2319 271848003645 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 271848003646 structural tetrad; other site 271848003647 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 271848003648 structural tetrad; other site 271848003649 FOG: WD40 repeat [General function prediction only]; Region: COG2319 271848003650 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 271848003651 dimerization interface [polypeptide binding]; other site 271848003652 active site 271848003653 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 271848003654 multidrug efflux protein; Reviewed; Region: PRK09579 271848003655 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 271848003656 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 271848003657 HlyD family secretion protein; Region: HlyD_3; pfam13437 271848003658 Predicted transcriptional regulator [Transcription]; Region: COG2345 271848003659 MarR family; Region: MarR_2; pfam12802 271848003660 Transcriptional regulator PadR-like family; Region: PadR; cl17335 271848003661 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 271848003662 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 271848003663 active site 271848003664 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 271848003665 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 271848003666 HlyD family secretion protein; Region: HlyD_3; pfam13437 271848003667 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 271848003668 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 271848003669 Walker A/P-loop; other site 271848003670 ATP binding site [chemical binding]; other site 271848003671 Q-loop/lid; other site 271848003672 ABC transporter signature motif; other site 271848003673 Walker B; other site 271848003674 D-loop; other site 271848003675 H-loop/switch region; other site 271848003676 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 271848003677 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 271848003678 Walker A/P-loop; other site 271848003679 ATP binding site [chemical binding]; other site 271848003680 Q-loop/lid; other site 271848003681 ABC transporter signature motif; other site 271848003682 Walker B; other site 271848003683 D-loop; other site 271848003684 H-loop/switch region; other site 271848003685 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 271848003686 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 271848003687 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 271848003688 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 271848003689 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 271848003690 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848003691 Walker A motif; other site 271848003692 ATP binding site [chemical binding]; other site 271848003693 Walker B motif; other site 271848003694 arginine finger; other site 271848003695 Peptidase family M41; Region: Peptidase_M41; pfam01434 271848003696 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 271848003697 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 271848003698 nudix motif; other site 271848003699 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 271848003700 Thymidylate synthase; Region: Thymidylat_synt; pfam00303 271848003701 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 271848003702 dimerization interface [polypeptide binding]; other site 271848003703 active site 271848003704 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848003705 S-adenosylmethionine binding site [chemical binding]; other site 271848003706 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 271848003707 dimer interface [polypeptide binding]; other site 271848003708 substrate binding site [chemical binding]; other site 271848003709 ATP binding site [chemical binding]; other site 271848003710 Mannan-binding protein; Region: MVL; pfam12151 271848003711 Methyltransferase domain; Region: Methyltransf_31; pfam13847 271848003712 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 271848003713 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 271848003714 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 271848003715 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 271848003716 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 271848003717 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 271848003718 Soluble P-type ATPase [General function prediction only]; Region: COG4087 271848003719 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 271848003720 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647 271848003721 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 271848003722 Soluble P-type ATPase [General function prediction only]; Region: COG4087 271848003723 Protein of unknown function (DUF3326); Region: DUF3326; pfam11805 271848003724 Archease protein family (MTH1598/TM1083); Region: Archease; pfam01951 271848003725 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 271848003726 hypothetical protein; Reviewed; Region: PRK09588 271848003727 GYD domain; Region: GYD; cl01743 271848003728 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 271848003729 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 271848003730 putative active site [active] 271848003731 putative metal binding site [ion binding]; other site 271848003732 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 271848003733 nucleotide binding site [chemical binding]; other site 271848003734 putative NEF/HSP70 interaction site [polypeptide binding]; other site 271848003735 SBD interface [polypeptide binding]; other site 271848003736 DNA-K related protein; Region: DUF3731; pfam12531 271848003737 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 271848003738 nucleotide binding site [chemical binding]; other site 271848003739 putative NEF/HSP70 interaction site [polypeptide binding]; other site 271848003740 SBD interface [polypeptide binding]; other site 271848003741 Domain of unknown function (DUF2760); Region: DUF2760; pfam10816 271848003742 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 271848003743 putative kissing complex interaction region; other site 271848003744 putative RNA binding sites [nucleotide binding]; other site 271848003745 ProQ/FINO family; Region: ProQ; pfam04352 271848003746 Activator of osmoprotectant transporter ProP [Signal transduction mechanisms]; Region: ProQ; COG3109 271848003747 H-NS histone family; Region: Histone_HNS; pfam00816 271848003748 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 271848003749 tail protein; Provisional; Region: D; PHA02561 271848003750 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 271848003751 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 271848003752 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 271848003753 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 271848003754 major tail tube protein; Provisional; Region: FII; PHA02600 271848003755 major tail sheath protein; Provisional; Region: FI; PHA02560 271848003756 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 271848003757 Phage Tail Collar Domain; Region: Collar; pfam07484 271848003758 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; pfam09684 271848003759 baseplate assembly protein; Provisional; Region: J; PHA02568 271848003760 baseplate wedge subunit; Provisional; Region: W; PHA02516 271848003761 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 271848003762 Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812 271848003763 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 271848003764 DNA methylase; Region: N6_N4_Mtase; pfam01555 271848003765 hypothetical protein; Region: PHA02416 271848003766 Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069 271848003767 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 271848003768 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 271848003769 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 271848003770 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 271848003771 Protein of unknown function (DUF3380); Region: DUF3380; pfam11860 271848003772 Protein of unknown function (DUF754); Region: DUF754; pfam05449 271848003773 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 271848003774 hypothetical protein; Region: PHA02417 271848003775 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 271848003776 terminase endonuclease subunit; Provisional; Region: M; PHA02537 271848003777 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 271848003778 capsid protein; Provisional; Region: N; PHA02538 271848003779 capsid-scaffolding protein; Provisional; Region: O; PHA02529 271848003780 terminase ATPase subunit; Provisional; Region: P; PHA02535 271848003781 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 271848003782 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 271848003783 portal vertex protein; Provisional; Region: Q; PHA02536 271848003784 Phage portal protein; Region: Phage_portal; pfam04860 271848003785 Protein of unknown function (DUF497); Region: DUF497; pfam04365 271848003786 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 271848003787 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 271848003788 VRR-NUC domain; Region: VRR_NUC; pfam08774 271848003789 PAAR motif; Region: PAAR_motif; pfam05488 271848003790 ParA-like protein; Provisional; Region: PHA02518 271848003791 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 271848003792 P-loop; other site 271848003793 Magnesium ion binding site [ion binding]; other site 271848003794 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 271848003795 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 271848003796 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 271848003797 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 271848003798 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 271848003799 cofactor binding site; other site 271848003800 DNA binding site [nucleotide binding] 271848003801 substrate interaction site [chemical binding]; other site 271848003802 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 271848003803 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 271848003804 Active Sites [active] 271848003805 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 271848003806 sequence-specific DNA binding site [nucleotide binding]; other site 271848003807 salt bridge; other site 271848003808 Phage related protein; Region: DUF3693; pfam12472 271848003809 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 271848003810 putative deacylase active site [active] 271848003811 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 271848003812 catalytic residue [active] 271848003813 Adenosine specific kinase; Region: Adenosine_kin; pfam04008 271848003814 Outer membrane efflux protein; Region: OEP; pfam02321 271848003815 Outer membrane efflux protein; Region: OEP; pfam02321 271848003816 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 271848003817 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 271848003818 HlyD family secretion protein; Region: HlyD_3; pfam13437 271848003819 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 271848003820 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 271848003821 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848003822 active site 271848003823 phosphorylation site [posttranslational modification] 271848003824 intermolecular recognition site; other site 271848003825 dimerization interface [polypeptide binding]; other site 271848003826 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 271848003827 DNA binding site [nucleotide binding] 271848003828 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 271848003829 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 271848003830 dimerization interface [polypeptide binding]; other site 271848003831 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271848003832 dimer interface [polypeptide binding]; other site 271848003833 phosphorylation site [posttranslational modification] 271848003834 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848003835 ATP binding site [chemical binding]; other site 271848003836 Mg2+ binding site [ion binding]; other site 271848003837 G-X-G motif; other site 271848003838 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 271848003839 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 271848003840 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 271848003841 active site 271848003842 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 271848003843 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 271848003844 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 271848003845 N-terminal plug; other site 271848003846 ligand-binding site [chemical binding]; other site 271848003847 fec operon regulator FecR; Reviewed; Region: PRK09774 271848003848 FecR protein; Region: FecR; pfam04773 271848003849 RNA polymerase sigma factor; Provisional; Region: PRK12528 271848003850 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 271848003851 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 271848003852 DNA binding residues [nucleotide binding] 271848003853 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 271848003854 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 271848003855 YceI-like domain; Region: YceI; smart00867 271848003856 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 271848003857 RNA polymerase sigma factor; Provisional; Region: PRK12511 271848003858 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 271848003859 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 271848003860 DNA binding residues [nucleotide binding] 271848003861 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 271848003862 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848003863 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 271848003864 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 271848003865 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 271848003866 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 271848003867 Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913 271848003868 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 271848003869 active site 271848003870 AMP binding site [chemical binding]; other site 271848003871 homodimer interface [polypeptide binding]; other site 271848003872 acyl-activating enzyme (AAE) consensus motif; other site 271848003873 CoA binding site [chemical binding]; other site 271848003874 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 271848003875 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848003876 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848003877 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 271848003878 putative effector binding pocket; other site 271848003879 dimerization interface [polypeptide binding]; other site 271848003880 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 271848003881 HPP family; Region: HPP; pfam04982 271848003882 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 271848003883 MarR family; Region: MarR_2; pfam12802 271848003884 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 271848003885 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 271848003886 Cl- selectivity filter; other site 271848003887 Cl- binding residues [ion binding]; other site 271848003888 pore gating glutamate residue; other site 271848003889 FOG: CBS domain [General function prediction only]; Region: COG0517 271848003890 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 271848003891 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848003892 S-adenosylmethionine binding site [chemical binding]; other site 271848003893 Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119 271848003894 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 271848003895 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 271848003896 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848003897 active site 271848003898 phosphorylation site [posttranslational modification] 271848003899 intermolecular recognition site; other site 271848003900 dimerization interface [polypeptide binding]; other site 271848003901 LytTr DNA-binding domain; Region: LytTR; smart00850 271848003902 Histidine kinase; Region: His_kinase; pfam06580 271848003903 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848003904 ATP binding site [chemical binding]; other site 271848003905 Mg2+ binding site [ion binding]; other site 271848003906 G-X-G motif; other site 271848003907 Integrase core domain; Region: rve_3; cl15866 271848003908 H+ Antiporter protein; Region: 2A0121; TIGR00900 271848003909 Uncharacterized conserved protein [Function unknown]; Region: COG3791 271848003910 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 271848003911 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 271848003912 putative active site [active] 271848003913 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 271848003914 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 271848003915 Walker A/P-loop; other site 271848003916 ATP binding site [chemical binding]; other site 271848003917 Q-loop/lid; other site 271848003918 ABC transporter signature motif; other site 271848003919 Walker B; other site 271848003920 D-loop; other site 271848003921 H-loop/switch region; other site 271848003922 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848003923 dimer interface [polypeptide binding]; other site 271848003924 conserved gate region; other site 271848003925 putative PBP binding loops; other site 271848003926 ABC-ATPase subunit interface; other site 271848003927 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 271848003928 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848003929 dimer interface [polypeptide binding]; other site 271848003930 conserved gate region; other site 271848003931 putative PBP binding loops; other site 271848003932 ABC-ATPase subunit interface; other site 271848003933 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 271848003934 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 271848003935 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 271848003936 trimer interface [polypeptide binding]; other site 271848003937 eyelet of channel; other site 271848003938 Predicted membrane protein [Function unknown]; Region: COG2259 271848003939 Cytochrome c; Region: Cytochrom_C; pfam00034 271848003940 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 271848003941 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 271848003942 Cytochrome c; Region: Cytochrom_C; pfam00034 271848003943 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 271848003944 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 271848003945 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 271848003946 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 271848003947 active site 271848003948 catalytic triad [active] 271848003949 magnesium-transporting ATPase; Provisional; Region: PRK15122 271848003950 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 271848003951 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 271848003952 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 271848003953 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 271848003954 motif II; other site 271848003955 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 271848003956 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 271848003957 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 271848003958 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 271848003959 DNA-binding site [nucleotide binding]; DNA binding site 271848003960 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 271848003961 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848003962 homodimer interface [polypeptide binding]; other site 271848003963 catalytic residue [active] 271848003964 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 271848003965 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 271848003966 putative molybdopterin cofactor binding site [chemical binding]; other site 271848003967 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 271848003968 putative molybdopterin cofactor binding site; other site 271848003969 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 271848003970 yiaA/B two helix domain; Region: YiaAB; pfam05360 271848003971 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 271848003972 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 271848003973 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 271848003974 Cupin; Region: Cupin_1; smart00835 271848003975 Cupin; Region: Cupin_1; smart00835 271848003976 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 271848003977 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 271848003978 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 271848003979 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 271848003980 catalytic triad [active] 271848003981 putative active site [active] 271848003982 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625 271848003983 Autotransporter beta-domain; Region: Autotransporter; pfam03797 271848003984 PAAR motif; Region: PAAR_motif; pfam05488 271848003985 RHS Repeat; Region: RHS_repeat; pfam05593 271848003986 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 271848003987 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 271848003988 RHS Repeat; Region: RHS_repeat; pfam05593 271848003989 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 271848003990 RHS Repeat; Region: RHS_repeat; cl11982 271848003991 RHS Repeat; Region: RHS_repeat; cl11982 271848003992 RHS Repeat; Region: RHS_repeat; cl11982 271848003993 RHS Repeat; Region: RHS_repeat; pfam05593 271848003994 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 271848003995 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 271848003996 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 271848003997 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 271848003998 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 271848003999 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 271848004000 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 271848004001 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 271848004002 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 271848004003 D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178 271848004004 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 271848004005 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 271848004006 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 271848004007 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848004008 dimer interface [polypeptide binding]; other site 271848004009 conserved gate region; other site 271848004010 putative PBP binding loops; other site 271848004011 ABC-ATPase subunit interface; other site 271848004012 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 271848004013 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848004014 dimer interface [polypeptide binding]; other site 271848004015 conserved gate region; other site 271848004016 putative PBP binding loops; other site 271848004017 ABC-ATPase subunit interface; other site 271848004018 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 271848004019 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 271848004020 Walker A/P-loop; other site 271848004021 ATP binding site [chemical binding]; other site 271848004022 Q-loop/lid; other site 271848004023 ABC transporter signature motif; other site 271848004024 Walker B; other site 271848004025 D-loop; other site 271848004026 H-loop/switch region; other site 271848004027 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 271848004028 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 271848004029 Walker A/P-loop; other site 271848004030 ATP binding site [chemical binding]; other site 271848004031 Q-loop/lid; other site 271848004032 ABC transporter signature motif; other site 271848004033 Walker B; other site 271848004034 D-loop; other site 271848004035 H-loop/switch region; other site 271848004036 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 271848004037 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848004038 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 271848004039 substrate binding pocket [chemical binding]; other site 271848004040 dimerization interface [polypeptide binding]; other site 271848004041 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 271848004042 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 271848004043 Peptidase family M23; Region: Peptidase_M23; pfam01551 271848004044 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848004045 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848004046 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 271848004047 putative dimerization interface [polypeptide binding]; other site 271848004048 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 271848004049 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 271848004050 trimer interface [polypeptide binding]; other site 271848004051 eyelet of channel; other site 271848004052 OpgC protein; Region: OpgC_C; pfam10129 271848004053 S-formylglutathione hydrolase; Region: PLN02442 271848004054 Putative esterase; Region: Esterase; pfam00756 271848004055 ornithine cyclodeaminase; Validated; Region: PRK07340 271848004056 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 271848004057 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 271848004058 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 271848004059 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652 271848004060 Ion channel; Region: Ion_trans_2; pfam07885 271848004061 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 271848004062 TrkA-N domain; Region: TrkA_N; pfam02254 271848004063 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 271848004064 BetR domain; Region: BetR; pfam08667 271848004065 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848004066 active site 271848004067 phosphorylation site [posttranslational modification] 271848004068 intermolecular recognition site; other site 271848004069 dimerization interface [polypeptide binding]; other site 271848004070 Part of AAA domain; Region: AAA_19; pfam13245 271848004071 Family description; Region: UvrD_C_2; pfam13538 271848004072 Tar ligand binding domain homologue; Region: TarH; pfam02203 271848004073 dimer interface [polypeptide binding]; other site 271848004074 ligand binding site [chemical binding]; other site 271848004075 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 271848004076 dimerization interface [polypeptide binding]; other site 271848004077 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 271848004078 dimer interface [polypeptide binding]; other site 271848004079 putative CheW interface [polypeptide binding]; other site 271848004080 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 271848004081 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848004082 putative substrate translocation pore; other site 271848004083 hypothetical protein; Provisional; Region: PRK12495 271848004084 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 271848004085 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 271848004086 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 271848004087 Coenzyme A binding pocket [chemical binding]; other site 271848004088 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg2; cd04778 271848004089 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 271848004090 DNA binding residues [nucleotide binding] 271848004091 putative dimer interface [polypeptide binding]; other site 271848004092 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 271848004093 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 271848004094 substrate binding pocket [chemical binding]; other site 271848004095 membrane-bound complex binding site; other site 271848004096 hinge residues; other site 271848004097 YhhN-like protein; Region: YhhN; pfam07947 271848004098 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 271848004099 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 271848004100 short chain dehydrogenase; Provisional; Region: PRK07832 271848004101 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848004102 NAD(P) binding site [chemical binding]; other site 271848004103 active site 271848004104 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 271848004105 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 271848004106 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 271848004107 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 271848004108 LysR family transcriptional regulator; Provisional; Region: PRK14997 271848004109 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848004110 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 271848004111 putative effector binding pocket; other site 271848004112 dimerization interface [polypeptide binding]; other site 271848004113 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 271848004114 Amidase; Region: Amidase; cl11426 271848004115 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 271848004116 Predicted transcriptional regulator [Transcription]; Region: COG1959 271848004117 Transcriptional regulator; Region: Rrf2; pfam02082 271848004118 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 271848004119 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 271848004120 methionine gamma-lyase; Validated; Region: PRK07049 271848004121 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 271848004122 homodimer interface [polypeptide binding]; other site 271848004123 substrate-cofactor binding pocket; other site 271848004124 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848004125 catalytic residue [active] 271848004126 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 271848004127 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 271848004128 putative Zn2+ binding site [ion binding]; other site 271848004129 putative DNA binding site [nucleotide binding]; other site 271848004130 AsnC family; Region: AsnC_trans_reg; pfam01037 271848004131 amidase; Provisional; Region: PRK07486 271848004132 Amidase; Region: Amidase; pfam01425 271848004133 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 271848004134 Ligand Binding Site [chemical binding]; other site 271848004135 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 271848004136 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 271848004137 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 271848004138 ligand binding site [chemical binding]; other site 271848004139 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 271848004140 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 271848004141 trimer interface [polypeptide binding]; other site 271848004142 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 271848004143 trimer interface [polypeptide binding]; other site 271848004144 Haemagglutinin; Region: HIM; pfam05662 271848004145 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 271848004146 trimer interface [polypeptide binding]; other site 271848004147 Haemagglutinin; Region: HIM; pfam05662 271848004148 Haemagglutinin; Region: HIM; pfam05662 271848004149 YadA-like C-terminal region; Region: YadA; pfam03895 271848004150 benzoate transport; Region: 2A0115; TIGR00895 271848004151 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848004152 putative substrate translocation pore; other site 271848004153 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848004154 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 271848004155 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 271848004156 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 271848004157 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 271848004158 active site 271848004159 metal binding site [ion binding]; metal-binding site 271848004160 C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360 271848004161 putative active site [active] 271848004162 putative metal binding site [ion binding]; other site 271848004163 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 271848004164 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 271848004165 NAD(P) binding site [chemical binding]; other site 271848004166 catalytic residues [active] 271848004167 L-aspartate dehydrogenase; Provisional; Region: PRK13303 271848004168 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 271848004169 Domain of unknown function DUF108; Region: DUF108; pfam01958 271848004170 hypothetical protein; Provisional; Region: PRK07064 271848004171 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 271848004172 PYR/PP interface [polypeptide binding]; other site 271848004173 dimer interface [polypeptide binding]; other site 271848004174 TPP binding site [chemical binding]; other site 271848004175 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 271848004176 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 271848004177 TPP-binding site [chemical binding]; other site 271848004178 short chain dehydrogenase; Provisional; Region: PRK07062 271848004179 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 271848004180 putative NAD(P) binding site [chemical binding]; other site 271848004181 putative active site [active] 271848004182 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 271848004183 Transcriptional regulator [Transcription]; Region: IclR; COG1414 271848004184 Bacterial transcriptional regulator; Region: IclR; pfam01614 271848004185 Serine hydrolase; Region: Ser_hydrolase; cl17834 271848004186 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 271848004187 Cupin domain; Region: Cupin_2; pfam07883 271848004188 short chain dehydrogenase; Provisional; Region: PRK12939 271848004189 classical (c) SDRs; Region: SDR_c; cd05233 271848004190 NAD(P) binding site [chemical binding]; other site 271848004191 active site 271848004192 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 271848004193 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 271848004194 iron-sulfur cluster [ion binding]; other site 271848004195 [2Fe-2S] cluster binding site [ion binding]; other site 271848004196 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 271848004197 hydrophobic ligand binding site; other site 271848004198 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 271848004199 [2Fe-2S] cluster binding site [ion binding]; other site 271848004200 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 271848004201 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 271848004202 trimer interface [polypeptide binding]; other site 271848004203 eyelet of channel; other site 271848004204 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 271848004205 Transcriptional regulator [Transcription]; Region: IclR; COG1414 271848004206 Bacterial transcriptional regulator; Region: IclR; pfam01614 271848004207 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 271848004208 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 271848004209 putative FMN binding site [chemical binding]; other site 271848004210 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 271848004211 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 271848004212 putative active site [active] 271848004213 putative metal binding site [ion binding]; other site 271848004214 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 271848004215 MgtC family; Region: MgtC; pfam02308 271848004216 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 271848004217 Autoinducer binding domain; Region: Autoind_bind; pfam03472 271848004218 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 271848004219 DNA binding residues [nucleotide binding] 271848004220 dimerization interface [polypeptide binding]; other site 271848004221 Autoinducer synthetase; Region: Autoind_synth; cl17404 271848004222 Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205 271848004223 NADH/NADPH cofactor binding site [chemical binding]; other site 271848004224 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 271848004225 dimerization interface [polypeptide binding]; other site 271848004226 active site 271848004227 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 271848004228 FOG: CBS domain [General function prediction only]; Region: COG0517 271848004229 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 271848004230 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 271848004231 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 271848004232 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 271848004233 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 271848004234 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 271848004235 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 271848004236 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 271848004237 trimer interface [polypeptide binding]; other site 271848004238 eyelet of channel; other site 271848004239 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 271848004240 putative DNA binding site [nucleotide binding]; other site 271848004241 dimerization interface [polypeptide binding]; other site 271848004242 putative Zn2+ binding site [ion binding]; other site 271848004243 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 271848004244 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 271848004245 FMN binding site [chemical binding]; other site 271848004246 active site 271848004247 substrate binding site [chemical binding]; other site 271848004248 catalytic residue [active] 271848004249 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 271848004250 Coenzyme A binding pocket [chemical binding]; other site 271848004251 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 271848004252 Transposase, Mutator family; Region: Transposase_mut; pfam00872 271848004253 MULE transposase domain; Region: MULE; pfam10551 271848004254 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 271848004255 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 271848004256 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 271848004257 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 271848004258 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 271848004259 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 271848004260 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 271848004261 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 271848004262 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 271848004263 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 271848004264 trimer interface [polypeptide binding]; other site 271848004265 eyelet of channel; other site 271848004266 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 271848004267 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848004268 Protein of unknown function (DUF3156); Region: DUF3156; pfam11354 271848004269 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 271848004270 hypothetical protein; Provisional; Region: PRK07481 271848004271 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 271848004272 inhibitor-cofactor binding pocket; inhibition site 271848004273 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848004274 catalytic residue [active] 271848004275 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 271848004276 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 271848004277 NAD(P) binding site [chemical binding]; other site 271848004278 catalytic residues [active] 271848004279 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 271848004280 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 271848004281 DNA binding residues [nucleotide binding] 271848004282 dimerization interface [polypeptide binding]; other site 271848004283 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 271848004284 classical (c) SDRs; Region: SDR_c; cd05233 271848004285 NAD(P) binding site [chemical binding]; other site 271848004286 active site 271848004287 Molybdenum cofactor biosynthesis protein F; Region: MoaF; pfam10703 271848004288 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 271848004289 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 271848004290 active site 271848004291 catalytic tetrad [active] 271848004292 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 271848004293 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 271848004294 catalytic residues [active] 271848004295 transcriptional regulator; Provisional; Region: PRK10632 271848004296 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848004297 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 271848004298 putative effector binding pocket; other site 271848004299 dimerization interface [polypeptide binding]; other site 271848004300 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 271848004301 flagellar capping protein; Reviewed; Region: fliD; PRK08032 271848004302 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 271848004303 Transposase; Region: DEDD_Tnp_IS110; pfam01548 271848004304 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 271848004305 allantoate amidohydrolase; Reviewed; Region: PRK12891 271848004306 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 271848004307 active site 271848004308 metal binding site [ion binding]; metal-binding site 271848004309 dimer interface [polypeptide binding]; other site 271848004310 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 271848004311 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 271848004312 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 271848004313 dimerization interface [polypeptide binding]; other site 271848004314 ligand binding site [chemical binding]; other site 271848004315 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 271848004316 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848004317 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 271848004318 dimerization interface [polypeptide binding]; other site 271848004319 substrate binding pocket [chemical binding]; other site 271848004320 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 271848004321 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 271848004322 DEAD_2; Region: DEAD_2; pfam06733 271848004323 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 271848004324 This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990 271848004325 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 271848004326 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 271848004327 substrate binding site [chemical binding]; other site 271848004328 dimer interface [polypeptide binding]; other site 271848004329 ATP binding site [chemical binding]; other site 271848004330 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 271848004331 active site 271848004332 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 271848004333 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 271848004334 DNA-binding protein H-NS [General function prediction only]; Region: Hns; COG2916 271848004335 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 271848004336 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 271848004337 sequence-specific DNA binding site [nucleotide binding]; other site 271848004338 salt bridge; other site 271848004339 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 271848004340 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848004341 NAD(P) binding site [chemical binding]; other site 271848004342 active site 271848004343 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 271848004344 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 271848004345 active site residue [active] 271848004346 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 271848004347 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 271848004348 catalytic Zn binding site [ion binding]; other site 271848004349 structural Zn binding site [ion binding]; other site 271848004350 NAD(P) binding site [chemical binding]; other site 271848004351 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 271848004352 Ligand Binding Site [chemical binding]; other site 271848004353 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 271848004354 Ligand Binding Site [chemical binding]; other site 271848004355 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 271848004356 Ligand Binding Site [chemical binding]; other site 271848004357 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 271848004358 Ligand Binding Site [chemical binding]; other site 271848004359 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 271848004360 Ligand Binding Site [chemical binding]; other site 271848004361 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 271848004362 Ligand Binding Site [chemical binding]; other site 271848004363 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 271848004364 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848004365 active site 271848004366 phosphorylation site [posttranslational modification] 271848004367 intermolecular recognition site; other site 271848004368 dimerization interface [polypeptide binding]; other site 271848004369 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 271848004370 DNA binding residues [nucleotide binding] 271848004371 dimerization interface [polypeptide binding]; other site 271848004372 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 271848004373 Protein of unknown function (DUF2964); Region: DUF2964; pfam11177 271848004374 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 271848004375 sequence-specific DNA binding site [nucleotide binding]; other site 271848004376 salt bridge; other site 271848004377 Cupin domain; Region: Cupin_2; pfam07883 271848004378 putative monooxygenase; Reviewed; Region: PRK07045 271848004379 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 271848004380 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 271848004381 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 271848004382 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 271848004383 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 271848004384 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 271848004385 ligand binding site [chemical binding]; other site 271848004386 Protein of unknown function (DUF3617); Region: DUF3617; pfam12276 271848004387 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 271848004388 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 271848004389 MG2 domain; Region: A2M_N; pfam01835 271848004390 Alpha-2-macroglobulin family; Region: A2M; pfam00207 271848004391 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 271848004392 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 271848004393 Transglycosylase; Region: Transgly; pfam00912 271848004394 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 271848004395 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 271848004396 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 271848004397 Response regulator receiver domain; Region: Response_reg; pfam00072 271848004398 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848004399 active site 271848004400 phosphorylation site [posttranslational modification] 271848004401 intermolecular recognition site; other site 271848004402 dimerization interface [polypeptide binding]; other site 271848004403 PAS fold; Region: PAS; pfam00989 271848004404 PAS domain; Region: PAS; smart00091 271848004405 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848004406 ATP binding site [chemical binding]; other site 271848004407 G-X-G motif; other site 271848004408 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 271848004409 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 271848004410 Protein of unknown function, DUF488; Region: DUF488; cl01246 271848004411 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 271848004412 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 271848004413 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848004414 homodimer interface [polypeptide binding]; other site 271848004415 catalytic residue [active] 271848004416 aromatic amino acid transporter; Provisional; Region: PRK10238 271848004417 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 271848004418 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 271848004419 putative DNA binding site [nucleotide binding]; other site 271848004420 putative Zn2+ binding site [ion binding]; other site 271848004421 AsnC family; Region: AsnC_trans_reg; pfam01037 271848004422 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 271848004423 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 271848004424 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 271848004425 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 271848004426 dimerization interface [polypeptide binding]; other site 271848004427 ligand binding site [chemical binding]; other site 271848004428 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 271848004429 CoenzymeA binding site [chemical binding]; other site 271848004430 subunit interaction site [polypeptide binding]; other site 271848004431 PHB binding site; other site 271848004432 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 271848004433 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 271848004434 Domain of unknown function (DUF718); Region: DUF718; cl01281 271848004435 short chain dehydrogenase; Provisional; Region: PRK08628 271848004436 classical (c) SDRs; Region: SDR_c; cd05233 271848004437 NAD(P) binding site [chemical binding]; other site 271848004438 active site 271848004439 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 271848004440 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 271848004441 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 271848004442 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848004443 NAD(P) binding site [chemical binding]; other site 271848004444 active site 271848004445 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 271848004446 Amidohydrolase; Region: Amidohydro_2; pfam04909 271848004447 active site 271848004448 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 271848004449 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 271848004450 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 271848004451 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 271848004452 TM-ABC transporter signature motif; other site 271848004453 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 271848004454 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 271848004455 Walker A/P-loop; other site 271848004456 ATP binding site [chemical binding]; other site 271848004457 Q-loop/lid; other site 271848004458 ABC transporter signature motif; other site 271848004459 Walker B; other site 271848004460 D-loop; other site 271848004461 H-loop/switch region; other site 271848004462 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 271848004463 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 271848004464 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 271848004465 ligand binding site [chemical binding]; other site 271848004466 Transcriptional regulator [Transcription]; Region: IclR; COG1414 271848004467 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 271848004468 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 271848004469 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 271848004470 DNA binding residues [nucleotide binding] 271848004471 dimer interface [polypeptide binding]; other site 271848004472 [2Fe-2S] cluster binding site [ion binding]; other site 271848004473 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 271848004474 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848004475 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848004476 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 271848004477 putative dimerization interface [polypeptide binding]; other site 271848004478 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 271848004479 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes sulfite sensitivity protein (sulfite efflux pump; SSU1); Region: TDT_SSU1; cd09318 271848004480 gating phenylalanine in ion channel; other site 271848004481 malate dehydrogenase; Provisional; Region: PRK05442 271848004482 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 271848004483 NAD(P) binding site [chemical binding]; other site 271848004484 dimer interface [polypeptide binding]; other site 271848004485 malate binding site [chemical binding]; other site 271848004486 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 271848004487 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 271848004488 Low-spin heme binding site [chemical binding]; other site 271848004489 D-pathway; other site 271848004490 Putative water exit pathway; other site 271848004491 Binuclear center (active site) [active] 271848004492 K-pathway; other site 271848004493 Putative proton exit pathway; other site 271848004494 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 271848004495 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 271848004496 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 271848004497 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 271848004498 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 271848004499 metal-binding site [ion binding] 271848004500 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 271848004501 Soluble P-type ATPase [General function prediction only]; Region: COG4087 271848004502 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 271848004503 Moco binding site; other site 271848004504 metal coordination site [ion binding]; other site 271848004505 Uncharacterized conserved protein [Function unknown]; Region: COG5649 271848004506 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 271848004507 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 271848004508 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 271848004509 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 271848004510 TM-ABC transporter signature motif; other site 271848004511 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 271848004512 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 271848004513 Walker A/P-loop; other site 271848004514 ATP binding site [chemical binding]; other site 271848004515 Q-loop/lid; other site 271848004516 ABC transporter signature motif; other site 271848004517 Walker B; other site 271848004518 D-loop; other site 271848004519 H-loop/switch region; other site 271848004520 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 271848004521 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 271848004522 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 271848004523 ligand binding site [chemical binding]; other site 271848004524 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 271848004525 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 271848004526 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 271848004527 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 271848004528 inhibitor site; inhibition site 271848004529 active site 271848004530 dimer interface [polypeptide binding]; other site 271848004531 catalytic residue [active] 271848004532 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 271848004533 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 271848004534 dimer interface [polypeptide binding]; other site 271848004535 NADP binding site [chemical binding]; other site 271848004536 catalytic residues [active] 271848004537 dihydroxy-acid dehydratase; Validated; Region: PRK06131 271848004538 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 271848004539 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848004540 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 271848004541 putative dimerization interface [polypeptide binding]; other site 271848004542 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 271848004543 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 271848004544 active site 271848004545 phosphorylation site [posttranslational modification] 271848004546 intermolecular recognition site; other site 271848004547 dimerization interface [polypeptide binding]; other site 271848004548 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 271848004549 DNA binding residues [nucleotide binding] 271848004550 dimerization interface [polypeptide binding]; other site 271848004551 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 271848004552 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 271848004553 Phosphoesterase family; Region: Phosphoesterase; pfam04185 271848004554 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 271848004555 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 271848004556 H-type lectin domain; Region: H_lectin; pfam09458 271848004557 cytosine deaminase; Provisional; Region: PRK09230 271848004558 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 271848004559 active site 271848004560 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 271848004561 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 271848004562 cytosine permease; Provisional; Region: codB; PRK11017 271848004563 Na binding site [ion binding]; other site 271848004564 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 271848004565 active site 271848004566 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 271848004567 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 271848004568 trimer interface [polypeptide binding]; other site 271848004569 eyelet of channel; other site 271848004570 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 271848004571 transcriptional regulator; Provisional; Region: PRK10632 271848004572 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848004573 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 271848004574 putative effector binding pocket; other site 271848004575 dimerization interface [polypeptide binding]; other site 271848004576 Fusaric acid resistance protein family; Region: FUSC; pfam04632 271848004577 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 271848004578 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 271848004579 catalytic core [active] 271848004580 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 271848004581 homodimer interface [polypeptide binding]; other site 271848004582 homotetramer interface [polypeptide binding]; other site 271848004583 active site pocket [active] 271848004584 cleavage site 271848004585 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 271848004586 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 271848004587 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 271848004588 DNA binding residues [nucleotide binding] 271848004589 dimerization interface [polypeptide binding]; other site 271848004590 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 271848004591 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 271848004592 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 271848004593 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 271848004594 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 271848004595 substrate binding pocket [chemical binding]; other site 271848004596 membrane-bound complex binding site; other site 271848004597 hinge residues; other site 271848004598 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 271848004599 Transposase; Region: DDE_Tnp_ISL3; pfam01610 271848004600 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 271848004601 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 271848004602 tetrameric interface [polypeptide binding]; other site 271848004603 NAD binding site [chemical binding]; other site 271848004604 catalytic residues [active] 271848004605 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 271848004606 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 271848004607 inhibitor-cofactor binding pocket; inhibition site 271848004608 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848004609 catalytic residue [active] 271848004610 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848004611 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848004612 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 271848004613 dimerization interface [polypeptide binding]; other site 271848004614 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 271848004615 2-oxoacid ferredoxin oxidoreductase; Provisional; Region: PRK13029 271848004616 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 271848004617 dimer interface [polypeptide binding]; other site 271848004618 PYR/PP interface [polypeptide binding]; other site 271848004619 TPP binding site [chemical binding]; other site 271848004620 substrate binding site [chemical binding]; other site 271848004621 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 271848004622 TPP-binding site; other site 271848004623 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 271848004624 Methyltransferase domain; Region: Methyltransf_12; pfam08242 271848004625 Methyltransferase domain; Region: Methyltransf_23; pfam13489 271848004626 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 271848004627 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 271848004628 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 271848004629 active site 271848004630 Methyltransferase in polyketide synthase (PKS) enzymes; Region: PKS_MT; smart00828 271848004631 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848004632 S-adenosylmethionine binding site [chemical binding]; other site 271848004633 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 271848004634 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 271848004635 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 271848004636 active site 271848004637 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 271848004638 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 271848004639 KR domain; Region: KR; pfam08659 271848004640 putative NADP binding site [chemical binding]; other site 271848004641 active site 271848004642 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 271848004643 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 271848004644 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 271848004645 active site 271848004646 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 271848004647 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 271848004648 putative NADP binding site [chemical binding]; other site 271848004649 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 271848004650 active site 271848004651 Methyltransferase domain; Region: Methyltransf_23; pfam13489 271848004652 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848004653 S-adenosylmethionine binding site [chemical binding]; other site 271848004654 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 271848004655 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 271848004656 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 271848004657 active site 271848004658 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 271848004659 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 271848004660 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 271848004661 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 271848004662 active site 271848004663 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 271848004664 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 271848004665 active site 271848004666 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 271848004667 KR domain; Region: KR; pfam08659 271848004668 putative NADP binding site [chemical binding]; other site 271848004669 active site 271848004670 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 271848004671 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 271848004672 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 271848004673 active site 271848004674 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 271848004675 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 271848004676 KR domain; Region: KR; pfam08659 271848004677 putative NADP binding site [chemical binding]; other site 271848004678 active site 271848004679 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 271848004680 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 271848004681 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 271848004682 active site 271848004683 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 271848004684 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 271848004685 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 271848004686 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 271848004687 active site 271848004688 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 271848004689 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 271848004690 putative NADP binding site [chemical binding]; other site 271848004691 active site 271848004692 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 271848004693 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 271848004694 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 271848004695 active site 271848004696 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 271848004697 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 271848004698 substrate binding site [chemical binding]; other site 271848004699 oxyanion hole (OAH) forming residues; other site 271848004700 trimer interface [polypeptide binding]; other site 271848004701 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 271848004702 substrate binding site [chemical binding]; other site 271848004703 oxyanion hole (OAH) forming residues; other site 271848004704 trimer interface [polypeptide binding]; other site 271848004705 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 271848004706 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 271848004707 dimer interface [polypeptide binding]; other site 271848004708 active site 271848004709 polyketide beta-ketoacyl:acyl carrier protein synthase; Validated; Region: PRK07103 271848004710 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 271848004711 dimer interface [polypeptide binding]; other site 271848004712 active site 271848004713 acyl carrier protein; Validated; Region: PRK07117 271848004714 Condensation domain; Region: Condensation; pfam00668 271848004715 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 271848004716 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 271848004717 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 271848004718 acyl-activating enzyme (AAE) consensus motif; other site 271848004719 AMP binding site [chemical binding]; other site 271848004720 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 271848004721 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 271848004722 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 271848004723 active site 271848004724 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 271848004725 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 271848004726 KR domain; Region: KR; pfam08659 271848004727 putative NADP binding site [chemical binding]; other site 271848004728 active site 271848004729 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 271848004730 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 271848004731 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 271848004732 active site 271848004733 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 271848004734 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 271848004735 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 271848004736 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 271848004737 active site 271848004738 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 271848004739 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 271848004740 putative NADP binding site [chemical binding]; other site 271848004741 active site 271848004742 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 271848004743 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 271848004744 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 271848004745 active site 271848004746 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 271848004747 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848004748 NAD(P) binding site [chemical binding]; other site 271848004749 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 271848004750 active site 271848004751 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 271848004752 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 271848004753 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 271848004754 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 271848004755 active site 271848004756 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 271848004757 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 271848004758 putative NADP binding site [chemical binding]; other site 271848004759 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 271848004760 active site 271848004761 Methyltransferase domain; Region: Methyltransf_12; pfam08242 271848004762 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 271848004763 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 271848004764 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 271848004765 active site 271848004766 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 271848004767 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 271848004768 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 271848004769 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 271848004770 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 271848004771 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 271848004772 FMN binding site [chemical binding]; other site 271848004773 substrate binding site [chemical binding]; other site 271848004774 putative catalytic residue [active] 271848004775 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 271848004776 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 271848004777 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848004778 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 271848004779 putative phosphoesterase; Region: acc_ester; TIGR03729 271848004780 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 271848004781 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 271848004782 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 271848004783 Autoinducer binding domain; Region: Autoind_bind; pfam03472 271848004784 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 271848004785 dimerization interface [polypeptide binding]; other site 271848004786 DNA binding residues [nucleotide binding] 271848004787 Cache domain; Region: Cache_1; pfam02743 271848004788 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 271848004789 dimer interface [polypeptide binding]; other site 271848004790 putative CheW interface [polypeptide binding]; other site 271848004791 acyl-CoA synthetase; Validated; Region: PRK08162 271848004792 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 271848004793 acyl-activating enzyme (AAE) consensus motif; other site 271848004794 putative active site [active] 271848004795 AMP binding site [chemical binding]; other site 271848004796 putative CoA binding site [chemical binding]; other site 271848004797 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 271848004798 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 271848004799 ligand binding site [chemical binding]; other site 271848004800 flexible hinge region; other site 271848004801 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 271848004802 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 271848004803 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848004804 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 271848004805 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848004806 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 271848004807 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 271848004808 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 271848004809 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 271848004810 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 271848004811 DNA-binding site [nucleotide binding]; DNA binding site 271848004812 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 271848004813 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848004814 homodimer interface [polypeptide binding]; other site 271848004815 catalytic residue [active] 271848004816 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 271848004817 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848004818 NAD(P) binding site [chemical binding]; other site 271848004819 active site 271848004820 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 271848004821 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 271848004822 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 271848004823 Coenzyme A binding pocket [chemical binding]; other site 271848004824 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533 271848004825 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 271848004826 NAD binding site [chemical binding]; other site 271848004827 homotetramer interface [polypeptide binding]; other site 271848004828 homodimer interface [polypeptide binding]; other site 271848004829 substrate binding site [chemical binding]; other site 271848004830 active site 271848004831 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 271848004832 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 271848004833 active site 271848004834 FMN binding site [chemical binding]; other site 271848004835 substrate binding site [chemical binding]; other site 271848004836 homotetramer interface [polypeptide binding]; other site 271848004837 catalytic residue [active] 271848004838 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 271848004839 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 271848004840 potential catalytic triad [active] 271848004841 conserved cys residue [active] 271848004842 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 271848004843 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 271848004844 TfuA-like protein; Region: TfuA; pfam07812 271848004845 Uncharacterized conserved protein [Function unknown]; Region: COG1944 271848004846 YcaO-like family; Region: YcaO; pfam02624 271848004847 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 271848004848 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 271848004849 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 271848004850 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 271848004851 FeS/SAM binding site; other site 271848004852 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 271848004853 bacteriocin maturation radical SAM protein 1; Region: rSAM_ocin_1; TIGR03975 271848004854 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 271848004855 B12 binding site [chemical binding]; other site 271848004856 Cupin superfamily protein; Region: Cupin_4; pfam08007 271848004857 Cupin-like domain; Region: Cupin_8; pfam13621 271848004858 Ubiquitin-like proteins; Region: UBQ; cl00155 271848004859 charged pocket; other site 271848004860 hydrophobic patch; other site 271848004861 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 271848004862 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 271848004863 Protein of unknown function (DUF3455); Region: DUF3455; pfam11937 271848004864 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 271848004865 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 271848004866 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 271848004867 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 271848004868 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 271848004869 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 271848004870 alanine racemase; Reviewed; Region: PRK13340 271848004871 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 271848004872 active site 271848004873 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 271848004874 substrate binding site [chemical binding]; other site 271848004875 catalytic residues [active] 271848004876 dimer interface [polypeptide binding]; other site 271848004877 enoyl-CoA hydratase; Validated; Region: PRK08139 271848004878 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 271848004879 substrate binding site [chemical binding]; other site 271848004880 oxyanion hole (OAH) forming residues; other site 271848004881 trimer interface [polypeptide binding]; other site 271848004882 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 271848004883 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 271848004884 trimer interface [polypeptide binding]; other site 271848004885 eyelet of channel; other site 271848004886 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 271848004887 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 271848004888 MOSC domain; Region: MOSC; pfam03473 271848004889 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 271848004890 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 271848004891 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271848004892 dimer interface [polypeptide binding]; other site 271848004893 phosphorylation site [posttranslational modification] 271848004894 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848004895 ATP binding site [chemical binding]; other site 271848004896 Mg2+ binding site [ion binding]; other site 271848004897 G-X-G motif; other site 271848004898 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 271848004899 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848004900 active site 271848004901 phosphorylation site [posttranslational modification] 271848004902 intermolecular recognition site; other site 271848004903 dimerization interface [polypeptide binding]; other site 271848004904 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 271848004905 DNA binding site [nucleotide binding] 271848004906 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 271848004907 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 271848004908 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 271848004909 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848004910 dimer interface [polypeptide binding]; other site 271848004911 conserved gate region; other site 271848004912 ABC-ATPase subunit interface; other site 271848004913 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848004914 dimer interface [polypeptide binding]; other site 271848004915 conserved gate region; other site 271848004916 putative PBP binding loops; other site 271848004917 ABC-ATPase subunit interface; other site 271848004918 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 271848004919 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 271848004920 Walker A/P-loop; other site 271848004921 ATP binding site [chemical binding]; other site 271848004922 Q-loop/lid; other site 271848004923 ABC transporter signature motif; other site 271848004924 Walker B; other site 271848004925 D-loop; other site 271848004926 H-loop/switch region; other site 271848004927 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 271848004928 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 271848004929 trimer interface [polypeptide binding]; other site 271848004930 eyelet of channel; other site 271848004931 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 271848004932 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 271848004933 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 271848004934 putative substrate binding pocket [chemical binding]; other site 271848004935 trimer interface [polypeptide binding]; other site 271848004936 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 271848004937 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 271848004938 putative active site [active] 271848004939 putative metal binding site [ion binding]; other site 271848004940 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 271848004941 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 271848004942 NAD binding site [chemical binding]; other site 271848004943 catalytic residues [active] 271848004944 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 271848004945 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 271848004946 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 271848004947 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 271848004948 MarR family; Region: MarR_2; cl17246 271848004949 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 271848004950 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 271848004951 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848004952 NAD(P) binding site [chemical binding]; other site 271848004953 active site 271848004954 MltA-interacting protein MipA; Region: MipA; cl01504 271848004955 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 271848004956 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848004957 active site 271848004958 phosphorylation site [posttranslational modification] 271848004959 intermolecular recognition site; other site 271848004960 dimerization interface [polypeptide binding]; other site 271848004961 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 271848004962 DNA binding site [nucleotide binding] 271848004963 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 271848004964 dimerization interface [polypeptide binding]; other site 271848004965 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271848004966 dimer interface [polypeptide binding]; other site 271848004967 phosphorylation site [posttranslational modification] 271848004968 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848004969 ATP binding site [chemical binding]; other site 271848004970 Mg2+ binding site [ion binding]; other site 271848004971 G-X-G motif; other site 271848004972 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 271848004973 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 271848004974 active site 271848004975 non-prolyl cis peptide bond; other site 271848004976 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 271848004977 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 271848004978 Flavin binding site [chemical binding]; other site 271848004979 Protein of unknown function (DUF3564); Region: DUF3564; pfam12087 271848004980 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 271848004981 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 271848004982 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848004983 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848004984 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 271848004985 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 271848004986 catalytic loop [active] 271848004987 iron binding site [ion binding]; other site 271848004988 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 271848004989 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 271848004990 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 271848004991 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 271848004992 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 271848004993 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 271848004994 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 271848004995 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 271848004996 DNA binding site [nucleotide binding] 271848004997 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 271848004998 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 271848004999 active site 271848005000 dimer interface [polypeptide binding]; other site 271848005001 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 271848005002 Ligand Binding Site [chemical binding]; other site 271848005003 Molecular Tunnel; other site 271848005004 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 271848005005 Autoinducer binding domain; Region: Autoind_bind; pfam03472 271848005006 putative transcriptional regulator; Provisional; Region: tfx; cl17550 271848005007 Autoinducer binding domain; Region: Autoind_bind; pfam03472 271848005008 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 271848005009 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 271848005010 DNA binding residues [nucleotide binding] 271848005011 dimerization interface [polypeptide binding]; other site 271848005012 Trehalase; Region: Trehalase; cl17346 271848005013 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848005014 Major Facilitator Superfamily; Region: MFS_1; pfam07690 271848005015 putative substrate translocation pore; other site 271848005016 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 271848005017 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 271848005018 Protein of unknown function (DUF1653); Region: DUF1653; pfam07866 271848005019 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 271848005020 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 271848005021 Coenzyme A binding pocket [chemical binding]; other site 271848005022 NnrU protein; Region: NnrU; pfam07298 271848005023 TfoX N-terminal domain; Region: TfoX_N; pfam04993 271848005024 hypothetical protein; Provisional; Region: PRK07907 271848005025 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682 271848005026 metal binding site [ion binding]; metal-binding site 271848005027 putative dimer interface [polypeptide binding]; other site 271848005028 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 271848005029 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 271848005030 conserved cys residue [active] 271848005031 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 271848005032 active site residue [active] 271848005033 Superinfection immunity protein; Region: Imm_superinfect; pfam14373 271848005034 Uncharacterized small protein (DUF2158); Region: DUF2158; pfam09926 271848005035 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 271848005036 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 271848005037 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 271848005038 putative active site [active] 271848005039 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 271848005040 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848005041 active site 271848005042 phosphorylation site [posttranslational modification] 271848005043 intermolecular recognition site; other site 271848005044 dimerization interface [polypeptide binding]; other site 271848005045 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 271848005046 DNA binding site [nucleotide binding] 271848005047 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271848005048 dimer interface [polypeptide binding]; other site 271848005049 phosphorylation site [posttranslational modification] 271848005050 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848005051 ATP binding site [chemical binding]; other site 271848005052 Mg2+ binding site [ion binding]; other site 271848005053 G-X-G motif; other site 271848005054 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 271848005055 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 271848005056 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 271848005057 C-terminal domain interface [polypeptide binding]; other site 271848005058 GSH binding site (G-site) [chemical binding]; other site 271848005059 dimer interface [polypeptide binding]; other site 271848005060 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 271848005061 N-terminal domain interface [polypeptide binding]; other site 271848005062 dimer interface [polypeptide binding]; other site 271848005063 substrate binding pocket (H-site) [chemical binding]; other site 271848005064 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 271848005065 putative dimer interface [polypeptide binding]; other site 271848005066 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 271848005067 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 271848005068 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 271848005069 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 271848005070 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 271848005071 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 271848005072 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625 271848005073 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 271848005074 Autotransporter beta-domain; Region: Autotransporter; pfam03797 271848005075 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 271848005076 Cytochrome c553 [Energy production and conversion]; Region: COG2863 271848005077 Cytochrome c; Region: Cytochrom_C; cl11414 271848005078 rod shape-determining protein MreB; Provisional; Region: PRK13930 271848005079 MreB and similar proteins; Region: MreB_like; cd10225 271848005080 nucleotide binding site [chemical binding]; other site 271848005081 Mg binding site [ion binding]; other site 271848005082 putative protofilament interaction site [polypeptide binding]; other site 271848005083 RodZ interaction site [polypeptide binding]; other site 271848005084 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 271848005085 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 271848005086 active site 271848005087 nucleophile elbow; other site 271848005088 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 271848005089 Surface antigen; Region: Bac_surface_Ag; pfam01103 271848005090 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271848005091 dimer interface [polypeptide binding]; other site 271848005092 phosphorylation site [posttranslational modification] 271848005093 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848005094 ATP binding site [chemical binding]; other site 271848005095 Mg2+ binding site [ion binding]; other site 271848005096 G-X-G motif; other site 271848005097 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 271848005098 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848005099 active site 271848005100 phosphorylation site [posttranslational modification] 271848005101 intermolecular recognition site; other site 271848005102 dimerization interface [polypeptide binding]; other site 271848005103 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 271848005104 DNA binding site [nucleotide binding] 271848005105 Glutaminase; Region: Glutaminase; cl00907 271848005106 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 271848005107 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 271848005108 glutaminase; Provisional; Region: PRK00971 271848005109 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 271848005110 B1 nucleotide binding pocket [chemical binding]; other site 271848005111 B2 nucleotide binding pocket [chemical binding]; other site 271848005112 CAS motifs; other site 271848005113 active site 271848005114 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 271848005115 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 271848005116 active site 271848005117 dimer interface [polypeptide binding]; other site 271848005118 non-prolyl cis peptide bond; other site 271848005119 insertion regions; other site 271848005120 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 271848005121 HlyD family secretion protein; Region: HlyD_3; pfam13437 271848005122 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 271848005123 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 271848005124 Walker A/P-loop; other site 271848005125 ATP binding site [chemical binding]; other site 271848005126 Q-loop/lid; other site 271848005127 ABC transporter signature motif; other site 271848005128 Walker B; other site 271848005129 D-loop; other site 271848005130 H-loop/switch region; other site 271848005131 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 271848005132 FtsX-like permease family; Region: FtsX; pfam02687 271848005133 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 271848005134 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 271848005135 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 271848005136 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 271848005137 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 271848005138 acyl-activating enzyme (AAE) consensus motif; other site 271848005139 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 271848005140 active site 271848005141 CoA binding site [chemical binding]; other site 271848005142 AMP binding site [chemical binding]; other site 271848005143 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 271848005144 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 271848005145 substrate binding site [chemical binding]; other site 271848005146 oxyanion hole (OAH) forming residues; other site 271848005147 trimer interface [polypeptide binding]; other site 271848005148 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 271848005149 enoyl-CoA hydratase; Provisional; Region: PRK09076 271848005150 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 271848005151 substrate binding site [chemical binding]; other site 271848005152 oxyanion hole (OAH) forming residues; other site 271848005153 trimer interface [polypeptide binding]; other site 271848005154 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 271848005155 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 271848005156 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 271848005157 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 271848005158 tetrameric interface [polypeptide binding]; other site 271848005159 NAD binding site [chemical binding]; other site 271848005160 catalytic residues [active] 271848005161 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 271848005162 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_1; cd05974 271848005163 active site 271848005164 acyl-activating enzyme (AAE) consensus motif; other site 271848005165 putative CoA binding site [chemical binding]; other site 271848005166 AMP binding site [chemical binding]; other site 271848005167 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 271848005168 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 271848005169 active site 271848005170 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 271848005171 Helix-turn-helix domain; Region: HTH_18; pfam12833 271848005172 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848005173 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 271848005174 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 271848005175 active site residues [active] 271848005176 dimer interface [polypeptide binding]; other site 271848005177 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 271848005178 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 271848005179 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 271848005180 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 271848005181 active site 271848005182 short chain dehydrogenase; Validated; Region: PRK05855 271848005183 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 271848005184 classical (c) SDRs; Region: SDR_c; cd05233 271848005185 NAD(P) binding site [chemical binding]; other site 271848005186 active site 271848005187 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 271848005188 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 271848005189 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 271848005190 TIGR02594 family protein; Region: TIGR02594 271848005191 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 271848005192 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 271848005193 Protein of unknown function (DUF2964); Region: DUF2964; pfam11177 271848005194 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 271848005195 GAF domain; Region: GAF; pfam01590 271848005196 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848005197 Walker A motif; other site 271848005198 ATP binding site [chemical binding]; other site 271848005199 Walker B motif; other site 271848005200 arginine finger; other site 271848005201 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 271848005202 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 271848005203 catalytic loop [active] 271848005204 iron binding site [ion binding]; other site 271848005205 siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718 271848005206 muropeptide transporter; Validated; Region: ampG; cl17669 271848005207 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 271848005208 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 271848005209 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 271848005210 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 271848005211 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 271848005212 N-terminal plug; other site 271848005213 ligand-binding site [chemical binding]; other site 271848005214 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 271848005215 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 271848005216 Walker A/P-loop; other site 271848005217 ATP binding site [chemical binding]; other site 271848005218 Q-loop/lid; other site 271848005219 ABC transporter signature motif; other site 271848005220 Walker B; other site 271848005221 D-loop; other site 271848005222 H-loop/switch region; other site 271848005223 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 271848005224 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 271848005225 Walker A/P-loop; other site 271848005226 ATP binding site [chemical binding]; other site 271848005227 Q-loop/lid; other site 271848005228 ABC transporter signature motif; other site 271848005229 Walker B; other site 271848005230 D-loop; other site 271848005231 H-loop/switch region; other site 271848005232 thiazolinyl imide reductase; Region: thiaz-red; TIGR01761 271848005233 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 271848005234 Condensation domain; Region: Condensation; pfam00668 271848005235 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 271848005236 Nonribosomal peptide synthase; Region: NRPS; pfam08415 271848005237 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 271848005238 acyl-activating enzyme (AAE) consensus motif; other site 271848005239 AMP binding site [chemical binding]; other site 271848005240 Methyltransferase domain; Region: Methyltransf_12; pfam08242 271848005241 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 271848005242 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 271848005243 Phosphopantetheine attachment site; Region: PP-binding; cl09936 271848005244 Condensation domain; Region: Condensation; pfam00668 271848005245 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 271848005246 Nonribosomal peptide synthase; Region: NRPS; pfam08415 271848005247 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 271848005248 acyl-activating enzyme (AAE) consensus motif; other site 271848005249 AMP binding site [chemical binding]; other site 271848005250 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 271848005251 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 271848005252 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 271848005253 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848005254 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 271848005255 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 271848005256 acyl-activating enzyme (AAE) consensus motif; other site 271848005257 active site 271848005258 AMP binding site [chemical binding]; other site 271848005259 substrate binding site [chemical binding]; other site 271848005260 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 271848005261 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 271848005262 nucleophilic elbow; other site 271848005263 catalytic triad; other site 271848005264 isochorismate-pyruvate lyase; Reviewed; Region: PRK07075 271848005265 salicylate biosynthesis isochorismate synthase; Validated; Region: PRK07054 271848005266 chorismate binding enzyme; Region: Chorismate_bind; cl10555 271848005267 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 271848005268 Peptidase family M23; Region: Peptidase_M23; pfam01551 271848005269 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 271848005270 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 271848005271 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 271848005272 Walker A/P-loop; other site 271848005273 ATP binding site [chemical binding]; other site 271848005274 Q-loop/lid; other site 271848005275 ABC transporter signature motif; other site 271848005276 Walker B; other site 271848005277 D-loop; other site 271848005278 H-loop/switch region; other site 271848005279 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 271848005280 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 271848005281 Walker A/P-loop; other site 271848005282 ATP binding site [chemical binding]; other site 271848005283 Q-loop/lid; other site 271848005284 ABC transporter signature motif; other site 271848005285 Walker B; other site 271848005286 D-loop; other site 271848005287 H-loop/switch region; other site 271848005288 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 271848005289 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 271848005290 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 271848005291 TM-ABC transporter signature motif; other site 271848005292 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 271848005293 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 271848005294 TM-ABC transporter signature motif; other site 271848005295 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 271848005296 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 271848005297 dimerization interface [polypeptide binding]; other site 271848005298 ligand binding site [chemical binding]; other site 271848005299 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 271848005300 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 271848005301 Domain of unknown function (DUF3331); Region: DUF3331; pfam11811 271848005302 short chain dehydrogenase; Provisional; Region: PRK06197 271848005303 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 271848005304 putative NAD(P) binding site [chemical binding]; other site 271848005305 active site 271848005306 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 271848005307 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 271848005308 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 271848005309 active site 271848005310 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 271848005311 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 271848005312 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 271848005313 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 271848005314 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 271848005315 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 271848005316 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 271848005317 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 271848005318 conserved cys residue [active] 271848005319 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848005320 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 271848005321 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 271848005322 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 271848005323 Zn binding site [ion binding]; other site 271848005324 M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase; Region: M28_AAP; cd03879 271848005325 Peptidase family M28; Region: Peptidase_M28; pfam04389 271848005326 active site 271848005327 metal binding site [ion binding]; metal-binding site 271848005328 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 271848005329 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 271848005330 trimer interface [polypeptide binding]; other site 271848005331 eyelet of channel; other site 271848005332 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 271848005333 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 271848005334 choline-sulfatase; Region: chol_sulfatase; TIGR03417 271848005335 Sulfatase; Region: Sulfatase; cl17466 271848005336 Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411 271848005337 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 271848005338 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848005339 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 271848005340 dimerization interface [polypeptide binding]; other site 271848005341 substrate binding pocket [chemical binding]; other site 271848005342 formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011 271848005343 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 271848005344 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 271848005345 putative active site [active] 271848005346 putative substrate binding site [chemical binding]; other site 271848005347 putative cosubstrate binding site; other site 271848005348 catalytic site [active] 271848005349 Amino acid permease; Region: AA_permease_2; pfam13520 271848005350 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 271848005351 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 271848005352 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 271848005353 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 271848005354 FAD binding pocket [chemical binding]; other site 271848005355 FAD binding motif [chemical binding]; other site 271848005356 phosphate binding motif [ion binding]; other site 271848005357 beta-alpha-beta structure motif; other site 271848005358 NAD binding pocket [chemical binding]; other site 271848005359 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 271848005360 catalytic loop [active] 271848005361 iron binding site [ion binding]; other site 271848005362 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 271848005363 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 271848005364 [2Fe-2S] cluster binding site [ion binding]; other site 271848005365 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 271848005366 putative alpha subunit interface [polypeptide binding]; other site 271848005367 putative active site [active] 271848005368 putative substrate binding site [chemical binding]; other site 271848005369 Fe binding site [ion binding]; other site 271848005370 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 271848005371 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 271848005372 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 271848005373 Domain of unknown function (DUF3483); Region: DUF3483; pfam11982 271848005374 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 271848005375 Cysteine-rich domain; Region: CCG; pfam02754 271848005376 Cysteine-rich domain; Region: CCG; pfam02754 271848005377 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 271848005378 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 271848005379 putative active site [active] 271848005380 putative FMN binding site [chemical binding]; other site 271848005381 putative substrate binding site [chemical binding]; other site 271848005382 putative catalytic residue [active] 271848005383 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 271848005384 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 271848005385 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 271848005386 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 271848005387 active site 271848005388 dimer interface [polypeptide binding]; other site 271848005389 serine hydroxymethyltransferase; Reviewed; Region: PRK13034 271848005390 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 271848005391 dimer interface [polypeptide binding]; other site 271848005392 active site 271848005393 glycine-pyridoxal phosphate binding site [chemical binding]; other site 271848005394 folate binding site [chemical binding]; other site 271848005395 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 271848005396 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 271848005397 conserved cys residue [active] 271848005398 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848005399 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 271848005400 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 271848005401 NAD binding site [chemical binding]; other site 271848005402 catalytic Zn binding site [ion binding]; other site 271848005403 structural Zn binding site [ion binding]; other site 271848005404 Transcriptional regulators [Transcription]; Region: PurR; COG1609 271848005405 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 271848005406 DNA binding site [nucleotide binding] 271848005407 domain linker motif; other site 271848005408 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 271848005409 ligand binding site [chemical binding]; other site 271848005410 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 271848005411 active site 271848005412 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 271848005413 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 271848005414 substrate binding [chemical binding]; other site 271848005415 active site 271848005416 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 271848005417 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 271848005418 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 271848005419 HlyD family secretion protein; Region: HlyD_3; pfam13437 271848005420 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 271848005421 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 271848005422 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 271848005423 Ligand binding site; other site 271848005424 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 271848005425 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848005426 putative substrate translocation pore; other site 271848005427 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848005428 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 271848005429 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 271848005430 active site 271848005431 TDP-binding site; other site 271848005432 acceptor substrate-binding pocket; other site 271848005433 homodimer interface [polypeptide binding]; other site 271848005434 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 271848005435 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 271848005436 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 271848005437 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 271848005438 hypothetical protein; Provisional; Region: PRK14693 271848005439 type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349 271848005440 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 271848005441 ligand binding site [chemical binding]; other site 271848005442 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 271848005443 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 271848005444 Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405 271848005445 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 271848005446 Protein of unknown function (DUF3540); Region: DUF3540; pfam12059 271848005447 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 271848005448 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 271848005449 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 271848005450 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 271848005451 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; cl02212 271848005452 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 271848005453 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 271848005454 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 271848005455 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 271848005456 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 271848005457 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 271848005458 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 271848005459 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 271848005460 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 271848005461 Clp amino terminal domain; Region: Clp_N; pfam02861 271848005462 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848005463 Walker A motif; other site 271848005464 ATP binding site [chemical binding]; other site 271848005465 Walker B motif; other site 271848005466 arginine finger; other site 271848005467 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 271848005468 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848005469 Walker A motif; other site 271848005470 ATP binding site [chemical binding]; other site 271848005471 Walker B motif; other site 271848005472 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 271848005473 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 271848005474 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 271848005475 Bacterial protein of unknown function (DUF879); Region: DUF879; cl15462 271848005476 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 271848005477 Protein of unknown function (DUF796); Region: DUF796; pfam05638 271848005478 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 271848005479 Protein of unknown function (DUF877); Region: DUF877; pfam05943 271848005480 type VI secretion protein, VC_A0107 family; Region: VI_chp_5; TIGR03358 271848005481 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 271848005482 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 271848005483 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 271848005484 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 271848005485 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 271848005486 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 271848005487 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 271848005488 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 271848005489 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 271848005490 active site 271848005491 metal-binding site 271848005492 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 271848005493 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 271848005494 tetramer interface [polypeptide binding]; other site 271848005495 active site 271848005496 Mg2+/Mn2+ binding site [ion binding]; other site 271848005497 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 271848005498 active site 271848005499 metal-binding site 271848005500 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 271848005501 phosphonopyruvate decarboxylase; Region: Ppyr-DeCO2ase; TIGR03297 271848005502 PYR/PP interface [polypeptide binding]; other site 271848005503 dimer interface [polypeptide binding]; other site 271848005504 TPP binding site [chemical binding]; other site 271848005505 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 271848005506 TPP-binding site [chemical binding]; other site 271848005507 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 271848005508 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 271848005509 catalytic residue [active] 271848005510 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 271848005511 conserved cys residue [active] 271848005512 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 271848005513 conserved cys residue [active] 271848005514 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 271848005515 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848005516 Predicted membrane protein [Function unknown]; Region: COG1289 271848005517 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 271848005518 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 271848005519 Lipase (class 2); Region: Lipase_2; pfam01674 271848005520 Major Facilitator Superfamily; Region: MFS_1; pfam07690 271848005521 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848005522 putative substrate translocation pore; other site 271848005523 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 271848005524 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 271848005525 DNA-binding site [nucleotide binding]; DNA binding site 271848005526 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 271848005527 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848005528 homodimer interface [polypeptide binding]; other site 271848005529 catalytic residue [active] 271848005530 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 271848005531 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 271848005532 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 271848005533 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; pfam04174 271848005534 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 271848005535 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 271848005536 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 271848005537 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 271848005538 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 271848005539 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 271848005540 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 271848005541 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 271848005542 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 271848005543 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 271848005544 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 271848005545 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 271848005546 Uncharacterized conserved protein [Function unknown]; Region: COG2308 271848005547 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 271848005548 putative FMN binding site [chemical binding]; other site 271848005549 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 271848005550 Chitin binding domain; Region: Chitin_bind_3; pfam03067 271848005551 peroxiredoxin; Region: AhpC; TIGR03137 271848005552 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 271848005553 dimer interface [polypeptide binding]; other site 271848005554 decamer (pentamer of dimers) interface [polypeptide binding]; other site 271848005555 catalytic triad [active] 271848005556 peroxidatic and resolving cysteines [active] 271848005557 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 271848005558 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 271848005559 catalytic residue [active] 271848005560 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 271848005561 catalytic residues [active] 271848005562 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 271848005563 MAPEG family; Region: MAPEG; cl09190 271848005564 acyl-CoA synthetase; Validated; Region: PRK05850 271848005565 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 271848005566 acyl-activating enzyme (AAE) consensus motif; other site 271848005567 active site 271848005568 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 271848005569 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 271848005570 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 271848005571 active site 271848005572 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 271848005573 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 271848005574 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 271848005575 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 271848005576 dimer interface [polypeptide binding]; other site 271848005577 active site 271848005578 CoA binding pocket [chemical binding]; other site 271848005579 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 271848005580 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 271848005581 active site 271848005582 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 271848005583 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 271848005584 acyl-activating enzyme (AAE) consensus motif; other site 271848005585 AMP binding site [chemical binding]; other site 271848005586 active site 271848005587 CoA binding site [chemical binding]; other site 271848005588 ribonucleotide reductase-like protein; Provisional; Region: PRK06948 271848005589 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 271848005590 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 271848005591 active site 271848005592 dimer interface [polypeptide binding]; other site 271848005593 effector binding site; other site 271848005594 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 271848005595 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 271848005596 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 271848005597 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 271848005598 ring oligomerisation interface [polypeptide binding]; other site 271848005599 ATP/Mg binding site [chemical binding]; other site 271848005600 stacking interactions; other site 271848005601 hinge regions; other site 271848005602 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 271848005603 oligomerisation interface [polypeptide binding]; other site 271848005604 mobile loop; other site 271848005605 roof hairpin; other site 271848005606 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 271848005607 oligomer interface [polypeptide binding]; other site 271848005608 agmatinase; Region: agmatinase; TIGR01230 271848005609 putative active site [active] 271848005610 Mn binding site [ion binding]; other site 271848005611 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 271848005612 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 271848005613 NAD(P) binding site [chemical binding]; other site 271848005614 catalytic residues [active] 271848005615 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 271848005616 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 271848005617 non-specific DNA binding site [nucleotide binding]; other site 271848005618 salt bridge; other site 271848005619 sequence-specific DNA binding site [nucleotide binding]; other site 271848005620 Cupin domain; Region: Cupin_2; pfam07883 271848005621 Peptidase C26; Region: Peptidase_C26; pfam07722 271848005622 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 271848005623 catalytic triad [active] 271848005624 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 271848005625 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 271848005626 putative aminotransferase; Validated; Region: PRK07480 271848005627 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 271848005628 inhibitor-cofactor binding pocket; inhibition site 271848005629 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848005630 catalytic residue [active] 271848005631 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 271848005632 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 271848005633 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 271848005634 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 271848005635 Walker A/P-loop; other site 271848005636 ATP binding site [chemical binding]; other site 271848005637 Q-loop/lid; other site 271848005638 ABC transporter signature motif; other site 271848005639 Walker B; other site 271848005640 D-loop; other site 271848005641 H-loop/switch region; other site 271848005642 TOBE domain; Region: TOBE_2; pfam08402 271848005643 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848005644 dimer interface [polypeptide binding]; other site 271848005645 conserved gate region; other site 271848005646 putative PBP binding loops; other site 271848005647 ABC-ATPase subunit interface; other site 271848005648 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 271848005649 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848005650 dimer interface [polypeptide binding]; other site 271848005651 conserved gate region; other site 271848005652 putative PBP binding loops; other site 271848005653 ABC-ATPase subunit interface; other site 271848005654 Protein of unknown function (DUF3138); Region: DUF3138; pfam11336 271848005655 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 271848005656 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 271848005657 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 271848005658 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 271848005659 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 271848005660 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 271848005661 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 271848005662 dimerization interface [polypeptide binding]; other site 271848005663 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 271848005664 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 271848005665 dimer interface [polypeptide binding]; other site 271848005666 putative CheW interface [polypeptide binding]; other site 271848005667 Copper resistance protein D; Region: CopD; cl00563 271848005668 CopC domain; Region: CopC; pfam04234 271848005669 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 271848005670 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 271848005671 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 271848005672 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 271848005673 Outer membrane efflux protein; Region: OEP; pfam02321 271848005674 Outer membrane efflux protein; Region: OEP; pfam02321 271848005675 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 271848005676 hypothetical protein; Provisional; Region: PRK08609 271848005677 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 271848005678 active site 271848005679 primer binding site [nucleotide binding]; other site 271848005680 NTP binding site [chemical binding]; other site 271848005681 metal binding triad [ion binding]; metal-binding site 271848005682 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 271848005683 active site 271848005684 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 271848005685 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 271848005686 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 271848005687 Putative amidotransferase; Region: DUF4066; pfam13278 271848005688 conserved cys residue [active] 271848005689 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 271848005690 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 271848005691 DNA-binding site [nucleotide binding]; DNA binding site 271848005692 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 271848005693 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848005694 homodimer interface [polypeptide binding]; other site 271848005695 catalytic residue [active] 271848005696 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 271848005697 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 271848005698 NAD binding site [chemical binding]; other site 271848005699 active site 271848005700 Pirin-related protein [General function prediction only]; Region: COG1741 271848005701 Pirin; Region: Pirin; pfam02678 271848005702 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848005703 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848005704 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 271848005705 putative effector binding pocket; other site 271848005706 dimerization interface [polypeptide binding]; other site 271848005707 Protein of unknown function (DUF1706); Region: DUF1706; cl01748 271848005708 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 271848005709 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 271848005710 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 271848005711 active site 271848005712 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 271848005713 trimer interface [polypeptide binding]; other site 271848005714 active site 271848005715 substrate binding site [chemical binding]; other site 271848005716 CoA binding site [chemical binding]; other site 271848005717 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 271848005718 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 271848005719 putative active site [active] 271848005720 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 271848005721 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 271848005722 putative active site [active] 271848005723 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 271848005724 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 271848005725 active site 271848005726 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 271848005727 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 271848005728 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 271848005729 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 271848005730 inhibitor-cofactor binding pocket; inhibition site 271848005731 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848005732 catalytic residue [active] 271848005733 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 271848005734 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 271848005735 inhibitor-cofactor binding pocket; inhibition site 271848005736 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848005737 catalytic residue [active] 271848005738 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 271848005739 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 271848005740 NAD binding site [chemical binding]; other site 271848005741 homotetramer interface [polypeptide binding]; other site 271848005742 homodimer interface [polypeptide binding]; other site 271848005743 substrate binding site [chemical binding]; other site 271848005744 active site 271848005745 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 271848005746 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 271848005747 substrate binding site; other site 271848005748 Chain length determinant protein; Region: Wzz; cl15801 271848005749 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 271848005750 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 271848005751 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 271848005752 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 271848005753 SLBB domain; Region: SLBB; pfam10531 271848005754 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 271848005755 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 271848005756 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 271848005757 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 271848005758 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 271848005759 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 271848005760 PYR/PP interface [polypeptide binding]; other site 271848005761 dimer interface [polypeptide binding]; other site 271848005762 TPP binding site [chemical binding]; other site 271848005763 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 271848005764 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 271848005765 TPP-binding site [chemical binding]; other site 271848005766 dimer interface [polypeptide binding]; other site 271848005767 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 271848005768 Bacterial Ig-like domain; Region: Big_5; pfam13205 271848005769 Bacterial Ig-like domain; Region: Big_5; pfam13205 271848005770 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 271848005771 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 271848005772 active site 271848005773 DNA binding site [nucleotide binding] 271848005774 Int/Topo IB signature motif; other site 271848005775 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 271848005776 YcfA-like protein; Region: YcfA; pfam07927 271848005777 PAAR motif; Region: PAAR_motif; pfam05488 271848005778 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 271848005779 VRR-NUC domain; Region: VRR_NUC; pfam08774 271848005780 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 271848005781 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 271848005782 multiple promoter invertase; Provisional; Region: mpi; PRK13413 271848005783 catalytic residues [active] 271848005784 catalytic nucleophile [active] 271848005785 Presynaptic Site I dimer interface [polypeptide binding]; other site 271848005786 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 271848005787 Synaptic Flat tetramer interface [polypeptide binding]; other site 271848005788 Synaptic Site I dimer interface [polypeptide binding]; other site 271848005789 DNA binding site [nucleotide binding] 271848005790 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 271848005791 DNA-binding interface [nucleotide binding]; DNA binding site 271848005792 AAA domain; Region: AAA_17; pfam13207 271848005793 AAA domain; Region: AAA_18; pfam13238 271848005794 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 271848005795 adenylosuccinate synthase; Region: purA; TIGR00184 271848005796 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 271848005797 Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707 271848005798 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 271848005799 active site 271848005800 metal binding site [ion binding]; metal-binding site 271848005801 interdomain interaction site; other site 271848005802 Domain of unknown function (DUF927); Region: DUF927; pfam06048 271848005803 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 271848005804 non-specific DNA binding site [nucleotide binding]; other site 271848005805 salt bridge; other site 271848005806 sequence-specific DNA binding site [nucleotide binding]; other site 271848005807 H-NS histone family; Region: Histone_HNS; pfam00816 271848005808 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 271848005809 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 271848005810 non-specific DNA binding site [nucleotide binding]; other site 271848005811 salt bridge; other site 271848005812 sequence-specific DNA binding site [nucleotide binding]; other site 271848005813 integrase; Provisional; Region: PRK09692 271848005814 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 271848005815 active site 271848005816 Int/Topo IB signature motif; other site 271848005817 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 271848005818 probable sodium:solute symporter, VC_2705 subfamily; Region: Na_symport_lg; TIGR03648 271848005819 Domain of unknown function (DUF4212); Region: DUF4212; pfam13937 271848005820 acetyl-CoA synthetase; Provisional; Region: PRK00174 271848005821 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 271848005822 active site 271848005823 CoA binding site [chemical binding]; other site 271848005824 acyl-activating enzyme (AAE) consensus motif; other site 271848005825 AMP binding site [chemical binding]; other site 271848005826 acetate binding site [chemical binding]; other site 271848005827 EamA-like transporter family; Region: EamA; pfam00892 271848005828 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 271848005829 EamA-like transporter family; Region: EamA; pfam00892 271848005830 hypothetical protein; Provisional; Region: PRK05208 271848005831 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 271848005832 Fumarase C-terminus; Region: Fumerase_C; pfam05683 271848005833 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 271848005834 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 271848005835 heme binding site [chemical binding]; other site 271848005836 ferroxidase pore; other site 271848005837 ferroxidase diiron center [ion binding]; other site 271848005838 glutamate racemase; Provisional; Region: PRK00865 271848005839 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 271848005840 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 271848005841 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 271848005842 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 271848005843 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 271848005844 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 271848005845 LysR family transcriptional regulator; Provisional; Region: PRK14997 271848005846 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848005847 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 271848005848 putative effector binding pocket; other site 271848005849 putative dimerization interface [polypeptide binding]; other site 271848005850 Pirin-related protein [General function prediction only]; Region: COG1741 271848005851 Pirin; Region: Pirin; pfam02678 271848005852 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 271848005853 DUF1857, an uncharacterized ligand-binding domain of the SRPBCC domain superfamily; Region: SRPBCC_DUF1857; cd08863 271848005854 putative hydrophobic ligand binding site [chemical binding]; other site 271848005855 Hemin uptake protein hemP; Region: hemP; pfam10636 271848005856 Domain of unknown function (DUF336); Region: DUF336; cl01249 271848005857 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 271848005858 4Fe-4S binding domain; Region: Fer4_5; pfam12801 271848005859 Iron permease FTR1 family; Region: FTR1; cl00475 271848005860 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 271848005861 Fe2+ transport protein; Region: Iron_transport; pfam10634 271848005862 excinuclease ABC subunit B; Provisional; Region: PRK05298 271848005863 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 271848005864 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 271848005865 ATP-binding site [chemical binding]; other site 271848005866 ATP binding site [chemical binding]; other site 271848005867 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 271848005868 nucleotide binding region [chemical binding]; other site 271848005869 ATP-binding site [chemical binding]; other site 271848005870 Ultra-violet resistance protein B; Region: UvrB; pfam12344 271848005871 UvrB/uvrC motif; Region: UVR; pfam02151 271848005872 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 271848005873 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 271848005874 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848005875 homodimer interface [polypeptide binding]; other site 271848005876 catalytic residue [active] 271848005877 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK13394 271848005878 classical (c) SDRs; Region: SDR_c; cd05233 271848005879 NAD(P) binding site [chemical binding]; other site 271848005880 active site 271848005881 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 271848005882 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 271848005883 active site 271848005884 catalytic tetrad [active] 271848005885 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 271848005886 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 271848005887 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 271848005888 DNA binding residues [nucleotide binding] 271848005889 dimer interface [polypeptide binding]; other site 271848005890 copper binding site [ion binding]; other site 271848005891 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 271848005892 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 271848005893 phosphonate degradation operons associated HDIG domain protein; Region: Phn-HD; TIGR03276 271848005894 putative phosphonoacetaldehyde dehydrogenase; Region: PhnAcAld_DH; TIGR03250 271848005895 Streptomyces putative phosphonoformaldehyde dehydrogenase PhpJ-like; Region: ALDH_PhpJ; cd07146 271848005896 NAD(P) binding site [chemical binding]; other site 271848005897 catalytic residues [active] 271848005898 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 271848005899 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 271848005900 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 271848005901 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 271848005902 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848005903 dimer interface [polypeptide binding]; other site 271848005904 conserved gate region; other site 271848005905 putative PBP binding loops; other site 271848005906 ABC-ATPase subunit interface; other site 271848005907 2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT; Region: PhnT; TIGR03258 271848005908 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 271848005909 Walker A/P-loop; other site 271848005910 ATP binding site [chemical binding]; other site 271848005911 Q-loop/lid; other site 271848005912 ABC transporter signature motif; other site 271848005913 Walker B; other site 271848005914 D-loop; other site 271848005915 H-loop/switch region; other site 271848005916 2-aminoethylphosphonate ABC transporter, periplasmic 2-aminoethylphosphonate binding protein; Region: PhnS; TIGR03227 271848005917 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 271848005918 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 271848005919 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 271848005920 catalytic residue [active] 271848005921 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848005922 D-galactonate transporter; Region: 2A0114; TIGR00893 271848005923 putative substrate translocation pore; other site 271848005924 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 271848005925 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 271848005926 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 271848005927 shikimate binding site; other site 271848005928 NAD(P) binding site [chemical binding]; other site 271848005929 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 271848005930 Dehydroquinase class II; Region: DHquinase_II; pfam01220 271848005931 active site 271848005932 trimer interface [polypeptide binding]; other site 271848005933 dimer interface [polypeptide binding]; other site 271848005934 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 271848005935 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 271848005936 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 271848005937 dimer interface [polypeptide binding]; other site 271848005938 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 271848005939 active site 271848005940 Fe binding site [ion binding]; other site 271848005941 L-lactate permease; Region: Lactate_perm; cl00701 271848005942 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 271848005943 malate synthase G; Provisional; Region: PRK02999 271848005944 active site 271848005945 PAS fold; Region: PAS_4; pfam08448 271848005946 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 271848005947 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848005948 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 271848005949 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 271848005950 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 271848005951 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 271848005952 hydroxyproline-2-epimerase; Provisional; Region: PRK13970 271848005953 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 271848005954 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 271848005955 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 271848005956 inhibitor site; inhibition site 271848005957 active site 271848005958 dimer interface [polypeptide binding]; other site 271848005959 catalytic residue [active] 271848005960 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 271848005961 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 271848005962 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 271848005963 dimer interface [polypeptide binding]; other site 271848005964 NADP binding site [chemical binding]; other site 271848005965 catalytic residues [active] 271848005966 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 271848005967 metabolite-proton symporter; Region: 2A0106; TIGR00883 271848005968 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848005969 putative substrate translocation pore; other site 271848005970 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848005971 putative substrate translocation pore; other site 271848005972 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848005973 Predicted membrane protein [Function unknown]; Region: COG2259 271848005974 glycolate transporter; Provisional; Region: PRK09695 271848005975 L-lactate permease; Region: Lactate_perm; cl00701 271848005976 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 271848005977 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 271848005978 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 271848005979 4Fe-4S binding domain; Region: Fer4; pfam00037 271848005980 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 271848005981 Cysteine-rich domain; Region: CCG; pfam02754 271848005982 Cysteine-rich domain; Region: CCG; pfam02754 271848005983 transcriptional regulator NanR; Provisional; Region: PRK03837 271848005984 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 271848005985 DNA-binding site [nucleotide binding]; DNA binding site 271848005986 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 271848005987 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 271848005988 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 271848005989 Flavin binding site [chemical binding]; other site 271848005990 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 271848005991 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 271848005992 active site 271848005993 non-prolyl cis peptide bond; other site 271848005994 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 271848005995 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 271848005996 Autoinducer binding domain; Region: Autoind_bind; pfam03472 271848005997 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 271848005998 DNA binding residues [nucleotide binding] 271848005999 dimerization interface [polypeptide binding]; other site 271848006000 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 271848006001 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 271848006002 AMP-binding enzyme; Region: AMP-binding; pfam00501 271848006003 acyl-activating enzyme (AAE) consensus motif; other site 271848006004 AMP binding site [chemical binding]; other site 271848006005 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 271848006006 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 271848006007 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 271848006008 active site 271848006009 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 271848006010 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 271848006011 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 271848006012 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848006013 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 271848006014 NAD(P) binding site [chemical binding]; other site 271848006015 active site 271848006016 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317 271848006017 Cysteine-rich motif following a subset of SET domains; Region: PostSET; smart00508 271848006018 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 271848006019 hypothetical protein; Provisional; Region: PRK07036 271848006020 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 271848006021 inhibitor-cofactor binding pocket; inhibition site 271848006022 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848006023 catalytic residue [active] 271848006024 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 271848006025 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 271848006026 tetrameric interface [polypeptide binding]; other site 271848006027 NAD binding site [chemical binding]; other site 271848006028 catalytic residues [active] 271848006029 substrate binding site [chemical binding]; other site 271848006030 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 271848006031 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 271848006032 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 271848006033 active site 271848006034 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 271848006035 putative NADP binding site [chemical binding]; other site 271848006036 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 271848006037 active site 271848006038 Methyltransferase domain; Region: Methyltransf_31; pfam13847 271848006039 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848006040 S-adenosylmethionine binding site [chemical binding]; other site 271848006041 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 271848006042 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 271848006043 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 271848006044 active site 271848006045 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 271848006046 Condensation domain; Region: Condensation; pfam00668 271848006047 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 271848006048 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 271848006049 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 271848006050 thioester reductase domain; Region: Thioester-redct; TIGR01746 271848006051 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 271848006052 putative NAD(P) binding site [chemical binding]; other site 271848006053 active site 271848006054 putative substrate binding site [chemical binding]; other site 271848006055 Ketol-acid reductoisomerase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvC; COG0059 271848006056 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 271848006057 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 271848006058 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 271848006059 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 271848006060 active site 271848006061 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 271848006062 substrate binding site [chemical binding]; other site 271848006063 catalytic residues [active] 271848006064 dimer interface [polypeptide binding]; other site 271848006065 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 271848006066 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 271848006067 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 271848006068 acyl-activating enzyme (AAE) consensus motif; other site 271848006069 AMP binding site [chemical binding]; other site 271848006070 active site 271848006071 CoA binding site [chemical binding]; other site 271848006072 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 271848006073 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 271848006074 acyl-CoA synthetase; Validated; Region: PRK05850 271848006075 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 271848006076 acyl-activating enzyme (AAE) consensus motif; other site 271848006077 active site 271848006078 Membrane transport protein; Region: Mem_trans; cl09117 271848006079 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 271848006080 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 271848006081 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 271848006082 Coenzyme A binding pocket [chemical binding]; other site 271848006083 Transcriptional regulators [Transcription]; Region: GntR; COG1802 271848006084 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 271848006085 DNA-binding site [nucleotide binding]; DNA binding site 271848006086 FCD domain; Region: FCD; pfam07729 271848006087 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 271848006088 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 271848006089 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 271848006090 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 271848006091 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 271848006092 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 271848006093 HlyD family secretion protein; Region: HlyD_3; pfam13437 271848006094 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 271848006095 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 271848006096 substrate binding pocket [chemical binding]; other site 271848006097 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 271848006098 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848006099 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848006100 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 271848006101 putative effector binding pocket; other site 271848006102 putative dimerization interface [polypeptide binding]; other site 271848006103 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 271848006104 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 271848006105 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 271848006106 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 271848006107 Purine nucleoside permease (NUP); Region: NUP; pfam06516 271848006108 4-oxalocrotonate tautomerase; Provisional; Region: PRK00745 271848006109 active site 1 [active] 271848006110 dimer interface [polypeptide binding]; other site 271848006111 hexamer interface [polypeptide binding]; other site 271848006112 active site 2 [active] 271848006113 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848006114 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 271848006115 putative effector binding pocket; other site 271848006116 putative dimerization interface [polypeptide binding]; other site 271848006117 selenophosphate synthetase; Provisional; Region: PRK00943 271848006118 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 271848006119 dimerization interface [polypeptide binding]; other site 271848006120 putative ATP binding site [chemical binding]; other site 271848006121 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 271848006122 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 271848006123 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 271848006124 DNA-binding site [nucleotide binding]; DNA binding site 271848006125 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 271848006126 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848006127 homodimer interface [polypeptide binding]; other site 271848006128 catalytic residue [active] 271848006129 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 271848006130 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 271848006131 inhibitor-cofactor binding pocket; inhibition site 271848006132 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848006133 catalytic residue [active] 271848006134 succinic semialdehyde dehydrogenase; Region: PLN02278 271848006135 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 271848006136 tetramerization interface [polypeptide binding]; other site 271848006137 NAD(P) binding site [chemical binding]; other site 271848006138 catalytic residues [active] 271848006139 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 271848006140 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 271848006141 iron-sulfur cluster [ion binding]; other site 271848006142 [2Fe-2S] cluster binding site [ion binding]; other site 271848006143 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 271848006144 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848006145 S-adenosylmethionine binding site [chemical binding]; other site 271848006146 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271848006147 PAS domain; Region: PAS_9; pfam13426 271848006148 putative active site [active] 271848006149 heme pocket [chemical binding]; other site 271848006150 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 271848006151 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 271848006152 dimer interface [polypeptide binding]; other site 271848006153 putative CheW interface [polypeptide binding]; other site 271848006154 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 271848006155 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 271848006156 dimer interface [polypeptide binding]; other site 271848006157 active site 271848006158 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 271848006159 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 271848006160 Bacterial transcriptional regulator; Region: IclR; pfam01614 271848006161 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 271848006162 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 271848006163 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 271848006164 metabolite-proton symporter; Region: 2A0106; TIGR00883 271848006165 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848006166 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848006167 dimerization interface [polypeptide binding]; other site 271848006168 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 271848006169 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 271848006170 substrate binding pocket [chemical binding]; other site 271848006171 membrane-bound complex binding site; other site 271848006172 hinge residues; other site 271848006173 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 271848006174 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 271848006175 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 271848006176 active site 271848006177 Zn binding site [ion binding]; other site 271848006178 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 271848006179 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 271848006180 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 271848006181 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 271848006182 trimer interface [polypeptide binding]; other site 271848006183 eyelet of channel; other site 271848006184 Protein of unknown function (DUF2866); Region: DUF2866; pfam11065 271848006185 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 271848006186 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 271848006187 N-terminal plug; other site 271848006188 ligand-binding site [chemical binding]; other site 271848006189 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 271848006190 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 271848006191 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 271848006192 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 271848006193 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 271848006194 intersubunit interface [polypeptide binding]; other site 271848006195 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 271848006196 putative PBP binding regions; other site 271848006197 ABC-ATPase subunit interface; other site 271848006198 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13547 271848006199 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 271848006200 Walker A/P-loop; other site 271848006201 ATP binding site [chemical binding]; other site 271848006202 Q-loop/lid; other site 271848006203 ABC transporter signature motif; other site 271848006204 Walker B; other site 271848006205 D-loop; other site 271848006206 H-loop/switch region; other site 271848006207 Predicted membrane protein [Function unknown]; Region: COG2860 271848006208 UPF0126 domain; Region: UPF0126; pfam03458 271848006209 UPF0126 domain; Region: UPF0126; pfam03458 271848006210 Transglycosylase; Region: Transgly; pfam00912 271848006211 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 271848006212 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 271848006213 chromosome replication initiation inhibitor protein; Provisional; Region: PRK13348 271848006214 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848006215 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 271848006216 putative dimerization interface [polypeptide binding]; other site 271848006217 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 271848006218 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 271848006219 tetramer interface [polypeptide binding]; other site 271848006220 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848006221 catalytic residue [active] 271848006222 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 271848006223 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 271848006224 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 271848006225 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 271848006226 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 271848006227 FMN binding site [chemical binding]; other site 271848006228 active site 271848006229 substrate binding site [chemical binding]; other site 271848006230 catalytic residue [active] 271848006231 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 271848006232 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 271848006233 active site 271848006234 catalytic tetrad [active] 271848006235 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 271848006236 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848006237 putative substrate translocation pore; other site 271848006238 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848006239 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848006240 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848006241 dimerization interface [polypeptide binding]; other site 271848006242 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 271848006243 active site lid residues [active] 271848006244 substrate binding pocket [chemical binding]; other site 271848006245 catalytic residues [active] 271848006246 substrate-Mg2+ binding site; other site 271848006247 aspartate-rich region 1; other site 271848006248 aspartate-rich region 2; other site 271848006249 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848006250 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848006251 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 271848006252 putative effector binding pocket; other site 271848006253 dimerization interface [polypeptide binding]; other site 271848006254 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 271848006255 dimer interface [polypeptide binding]; other site 271848006256 FMN binding site [chemical binding]; other site 271848006257 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 271848006258 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 271848006259 substrate binding pocket [chemical binding]; other site 271848006260 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 271848006261 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848006262 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848006263 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 271848006264 putative effector binding pocket; other site 271848006265 dimerization interface [polypeptide binding]; other site 271848006266 choline dehydrogenase; Validated; Region: PRK02106 271848006267 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 271848006268 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 271848006269 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 271848006270 NAD(P) binding site [chemical binding]; other site 271848006271 catalytic residues [active] 271848006272 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 271848006273 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 271848006274 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 271848006275 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 271848006276 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 271848006277 Uncharacterized conserved protein [Function unknown]; Region: COG5361 271848006278 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 271848006279 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 271848006280 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 271848006281 Heavy-metal-associated domain; Region: HMA; pfam00403 271848006282 metal-binding site [ion binding] 271848006283 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 271848006284 metal-binding site [ion binding] 271848006285 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 271848006286 metal-binding site [ion binding] 271848006287 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 271848006288 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 271848006289 Protein of unknown function (DUF4087); Region: DUF4087; pfam13316 271848006290 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 271848006291 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 271848006292 Coenzyme A binding pocket [chemical binding]; other site 271848006293 MgtC family; Region: MgtC; pfam02308 271848006294 dimerization interface [polypeptide binding]; other site 271848006295 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 271848006296 putative active cleft [active] 271848006297 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 271848006298 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848006299 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 271848006300 dimerization interface [polypeptide binding]; other site 271848006301 substrate binding pocket [chemical binding]; other site 271848006302 Major Facilitator Superfamily; Region: MFS_1; pfam07690 271848006303 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848006304 putative substrate translocation pore; other site 271848006305 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848006306 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 271848006307 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 271848006308 dimer interface [polypeptide binding]; other site 271848006309 ligand binding site [chemical binding]; other site 271848006310 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 271848006311 dimer interface [polypeptide binding]; other site 271848006312 putative CheW interface [polypeptide binding]; other site 271848006313 Y_X(10)_GDL-associated radical SAM protein; Region: rad_SAM_trio; TIGR03913 271848006314 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 271848006315 FeS/SAM binding site; other site 271848006316 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 271848006317 Domain of unknown function (DUF1842); Region: DUF1842; pfam08896 271848006318 Domain of unknown function (DUF1843); Region: DUF1843; pfam08898 271848006319 Domain of unknown function (DUF1842); Region: DUF1842; pfam08896 271848006320 Domain of unknown function (DUF1843); Region: DUF1843; pfam08898 271848006321 Domain of unknown function (DUF1843); Region: DUF1843; pfam08898 271848006322 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 271848006323 CoenzymeA binding site [chemical binding]; other site 271848006324 subunit interaction site [polypeptide binding]; other site 271848006325 PHB binding site; other site 271848006326 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 271848006327 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 271848006328 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 271848006329 substrate binding site [chemical binding]; other site 271848006330 ligand binding site [chemical binding]; other site 271848006331 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 271848006332 substrate binding site [chemical binding]; other site 271848006333 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 271848006334 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 271848006335 dimer interface [polypeptide binding]; other site 271848006336 active site 271848006337 citrylCoA binding site [chemical binding]; other site 271848006338 oxalacetate/citrate binding site [chemical binding]; other site 271848006339 coenzyme A binding site [chemical binding]; other site 271848006340 catalytic triad [active] 271848006341 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 271848006342 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 271848006343 tetramer interface [polypeptide binding]; other site 271848006344 active site 271848006345 Mg2+/Mn2+ binding site [ion binding]; other site 271848006346 Propionate catabolism activator; Region: PrpR_N; pfam06506 271848006347 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 271848006348 PAS domain; Region: PAS; smart00091 271848006349 putative active site [active] 271848006350 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848006351 Walker A motif; other site 271848006352 ATP binding site [chemical binding]; other site 271848006353 Walker B motif; other site 271848006354 arginine finger; other site 271848006355 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 271848006356 dimer interface [polypeptide binding]; other site 271848006357 putative CheW interface [polypeptide binding]; other site 271848006358 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 271848006359 TAP-like protein; Region: Abhydrolase_4; pfam08386 271848006360 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 271848006361 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 271848006362 dimer interface [polypeptide binding]; other site 271848006363 putative metal binding site [ion binding]; other site 271848006364 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084 271848006365 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 271848006366 homodimer interface [polypeptide binding]; other site 271848006367 substrate-cofactor binding pocket; other site 271848006368 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848006369 catalytic residue [active] 271848006370 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 271848006371 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 271848006372 conserved cys residue [active] 271848006373 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848006374 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848006375 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 271848006376 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 271848006377 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 271848006378 Transcriptional regulator [Transcription]; Region: IclR; COG1414 271848006379 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 271848006380 Bacterial transcriptional regulator; Region: IclR; pfam01614 271848006381 DDE superfamily endonuclease; Region: DDE_5; cl17874 271848006382 amidohydrolase, AtzE family; Region: amido_AtzE; TIGR02715 271848006383 Amidase; Region: Amidase; pfam01425 271848006384 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 271848006385 CoA binding domain; Region: CoA_binding_2; pfam13380 271848006386 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 271848006387 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 271848006388 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 271848006389 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 271848006390 Coenzyme A binding pocket [chemical binding]; other site 271848006391 H-NS histone family; Region: Histone_HNS; pfam00816 271848006392 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 271848006393 PAS fold; Region: PAS_4; pfam08448 271848006394 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 271848006395 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848006396 Walker B motif; other site 271848006397 arginine finger; other site 271848006398 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 271848006399 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 271848006400 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 271848006401 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 271848006402 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 271848006403 active site residue [active] 271848006404 outer membrane porin, OprD family; Region: OprD; pfam03573 271848006405 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 271848006406 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 271848006407 Walker A/P-loop; other site 271848006408 ATP binding site [chemical binding]; other site 271848006409 Q-loop/lid; other site 271848006410 ABC transporter signature motif; other site 271848006411 Walker B; other site 271848006412 D-loop; other site 271848006413 H-loop/switch region; other site 271848006414 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 271848006415 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 271848006416 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 271848006417 Walker A/P-loop; other site 271848006418 ATP binding site [chemical binding]; other site 271848006419 Q-loop/lid; other site 271848006420 ABC transporter signature motif; other site 271848006421 Walker B; other site 271848006422 D-loop; other site 271848006423 H-loop/switch region; other site 271848006424 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 271848006425 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 271848006426 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848006427 dimer interface [polypeptide binding]; other site 271848006428 conserved gate region; other site 271848006429 putative PBP binding loops; other site 271848006430 ABC-ATPase subunit interface; other site 271848006431 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 271848006432 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848006433 dimer interface [polypeptide binding]; other site 271848006434 conserved gate region; other site 271848006435 putative PBP binding loops; other site 271848006436 ABC-ATPase subunit interface; other site 271848006437 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 271848006438 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 271848006439 peptide binding site [polypeptide binding]; other site 271848006440 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 271848006441 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 271848006442 non-specific DNA binding site [nucleotide binding]; other site 271848006443 salt bridge; other site 271848006444 sequence-specific DNA binding site [nucleotide binding]; other site 271848006445 Cupin domain; Region: Cupin_2; pfam07883 271848006446 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 271848006447 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848006448 putative substrate translocation pore; other site 271848006449 POT family; Region: PTR2; cl17359 271848006450 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 271848006451 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848006452 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 271848006453 substrate binding pocket [chemical binding]; other site 271848006454 dimerization interface [polypeptide binding]; other site 271848006455 Putative cyclase; Region: Cyclase; cl00814 271848006456 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 271848006457 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 271848006458 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 271848006459 CoA-transferase family III; Region: CoA_transf_3; pfam02515 271848006460 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 271848006461 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 271848006462 NAD(P) binding site [chemical binding]; other site 271848006463 Isochorismatase family; Region: Isochorismatase; pfam00857 271848006464 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 271848006465 catalytic triad [active] 271848006466 conserved cis-peptide bond; other site 271848006467 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848006468 Major Facilitator Superfamily; Region: MFS_1; pfam07690 271848006469 putative substrate translocation pore; other site 271848006470 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848006471 benzoate transport; Region: 2A0115; TIGR00895 271848006472 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848006473 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848006474 putative substrate translocation pore; other site 271848006475 Putative cyclase; Region: Cyclase; cl00814 271848006476 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 271848006477 CoA-transferase family III; Region: CoA_transf_3; pfam02515 271848006478 Transcriptional regulator [Transcription]; Region: IclR; COG1414 271848006479 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 271848006480 Bacterial transcriptional regulator; Region: IclR; pfam01614 271848006481 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 271848006482 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 271848006483 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 271848006484 trimer interface [polypeptide binding]; other site 271848006485 eyelet of channel; other site 271848006486 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 271848006487 OpgC protein; Region: OpgC_C; pfam10129 271848006488 Predicted permeases [General function prediction only]; Region: RarD; COG2962 271848006489 acylphosphatase; Provisional; Region: PRK14424 271848006490 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 271848006491 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 271848006492 putative NADP binding site [chemical binding]; other site 271848006493 putative substrate binding site [chemical binding]; other site 271848006494 active site 271848006495 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 271848006496 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 271848006497 active site 271848006498 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 271848006499 LytB protein; Region: LYTB; pfam02401 271848006500 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 271848006501 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 271848006502 FeS/SAM binding site; other site 271848006503 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 271848006504 Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; pfam08883 271848006505 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 271848006506 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848006507 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848006508 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 271848006509 putative substrate binding pocket [chemical binding]; other site 271848006510 putative dimerization interface [polypeptide binding]; other site 271848006511 aminotransferase; Validated; Region: PRK07046 271848006512 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 271848006513 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 271848006514 catalytic residue [active] 271848006515 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 271848006516 sequence-specific DNA binding site [nucleotide binding]; other site 271848006517 salt bridge; other site 271848006518 Protein of unknown function (DUF466); Region: DUF466; pfam04328 271848006519 carbon starvation protein A; Provisional; Region: PRK15015 271848006520 Carbon starvation protein CstA; Region: CstA; pfam02554 271848006521 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 271848006522 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 271848006523 Uncharacterized conserved protein [Function unknown]; Region: COG5476 271848006524 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 271848006525 MlrC C-terminus; Region: MlrC_C; pfam07171 271848006526 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848006527 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848006528 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848006529 dimerization interface [polypeptide binding]; other site 271848006530 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 271848006531 GtrA-like protein; Region: GtrA; pfam04138 271848006532 Methyltransferase domain; Region: Methyltransf_23; pfam13489 271848006533 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848006534 S-adenosylmethionine binding site [chemical binding]; other site 271848006535 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 271848006536 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 271848006537 Ligand binding site; other site 271848006538 Putative Catalytic site; other site 271848006539 DXD motif; other site 271848006540 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 271848006541 Flp/Fap pilin component; Region: Flp_Fap; cl01585 271848006542 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 271848006543 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 271848006544 active site 271848006545 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 271848006546 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 271848006547 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 271848006548 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 271848006549 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 271848006550 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 271848006551 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 271848006552 TadE-like protein; Region: TadE; pfam07811 271848006553 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 271848006554 TadE-like protein; Region: TadE; pfam07811 271848006555 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 271848006556 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 271848006557 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 271848006558 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 271848006559 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 271848006560 ATP binding site [chemical binding]; other site 271848006561 Walker A motif; other site 271848006562 hexamer interface [polypeptide binding]; other site 271848006563 Walker B motif; other site 271848006564 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 271848006565 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 271848006566 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 271848006567 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 271848006568 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 271848006569 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 271848006570 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 271848006571 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 271848006572 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 271848006573 putative DNA binding site [nucleotide binding]; other site 271848006574 putative Zn2+ binding site [ion binding]; other site 271848006575 AsnC family; Region: AsnC_trans_reg; pfam01037 271848006576 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 271848006577 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 271848006578 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848006579 homodimer interface [polypeptide binding]; other site 271848006580 catalytic residue [active] 271848006581 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 271848006582 homotrimer interaction site [polypeptide binding]; other site 271848006583 putative active site [active] 271848006584 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 271848006585 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 271848006586 trimer interface [polypeptide binding]; other site 271848006587 eyelet of channel; other site 271848006588 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 271848006589 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 271848006590 DNA-binding site [nucleotide binding]; DNA binding site 271848006591 Transcriptional regulators [Transcription]; Region: FadR; COG2186 271848006592 FCD domain; Region: FCD; pfam07729 271848006593 Uncharacterized conserved protein [Function unknown]; Region: COG5476 271848006594 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 271848006595 MlrC C-terminus; Region: MlrC_C; pfam07171 271848006596 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 271848006597 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848006598 putative substrate translocation pore; other site 271848006599 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848006600 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848006601 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848006602 dimerization interface [polypeptide binding]; other site 271848006603 Protein of unknown function (DUF3175); Region: DUF3175; pfam11373 271848006604 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 271848006605 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 271848006606 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 271848006607 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 271848006608 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 271848006609 active site 271848006610 non-prolyl cis peptide bond; other site 271848006611 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 271848006612 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 271848006613 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848006614 Major Facilitator Superfamily; Region: MFS_1; pfam07690 271848006615 putative substrate translocation pore; other site 271848006616 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 271848006617 Autoinducer binding domain; Region: Autoind_bind; pfam03472 271848006618 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 271848006619 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 271848006620 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 271848006621 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 271848006622 E3 interaction surface; other site 271848006623 lipoyl attachment site [posttranslational modification]; other site 271848006624 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 271848006625 e3 binding domain; Region: E3_binding; pfam02817 271848006626 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 271848006627 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 271848006628 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 271848006629 alpha subunit interface [polypeptide binding]; other site 271848006630 TPP binding site [chemical binding]; other site 271848006631 heterodimer interface [polypeptide binding]; other site 271848006632 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 271848006633 2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573 271848006634 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 271848006635 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 271848006636 tetramer interface [polypeptide binding]; other site 271848006637 TPP-binding site [chemical binding]; other site 271848006638 heterodimer interface [polypeptide binding]; other site 271848006639 phosphorylation loop region [posttranslational modification] 271848006640 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 271848006641 putative hydrophobic ligand binding site [chemical binding]; other site 271848006642 protein interface [polypeptide binding]; other site 271848006643 gate; other site 271848006644 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 271848006645 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 271848006646 hydrophobic ligand binding site; other site 271848006647 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848006648 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848006649 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 271848006650 substrate binding pocket [chemical binding]; other site 271848006651 dimerization interface [polypeptide binding]; other site 271848006652 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 271848006653 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 271848006654 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 271848006655 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 271848006656 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 271848006657 nucleophile elbow; other site 271848006658 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 271848006659 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 271848006660 ribonucleotide reductase-like protein; Provisional; Region: PRK06948 271848006661 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 271848006662 active site 271848006663 dimer interface [polypeptide binding]; other site 271848006664 effector binding site; other site 271848006665 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 271848006666 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 271848006667 AAA domain; Region: AAA_33; pfam13671 271848006668 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 271848006669 FMN binding site [chemical binding]; other site 271848006670 dimer interface [polypeptide binding]; other site 271848006671 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 271848006672 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 271848006673 Sulfate transporter family; Region: Sulfate_transp; pfam00916 271848006674 Sulfate transporter family; Region: Sulfate_transp; pfam00916 271848006675 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 271848006676 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 271848006677 FOG: CBS domain [General function prediction only]; Region: COG0517 271848006678 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 271848006679 putative FMN binding site [chemical binding]; other site 271848006680 NADPH bind site [chemical binding]; other site 271848006681 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 271848006682 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 271848006683 putative dimer interface [polypeptide binding]; other site 271848006684 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 271848006685 putative active site [active] 271848006686 putative metal binding site [ion binding]; other site 271848006687 Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200 271848006688 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 271848006689 Transglycosylase; Region: Transgly; pfam00912 271848006690 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 271848006691 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 271848006692 PAAR motif; Region: PAAR_motif; pfam05488 271848006693 amidase; Provisional; Region: PRK08137 271848006694 Amidase; Region: Amidase; cl11426 271848006695 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 271848006696 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 271848006697 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 271848006698 Histidine kinase; Region: HisKA_3; pfam07730 271848006699 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848006700 ATP binding site [chemical binding]; other site 271848006701 Mg2+ binding site [ion binding]; other site 271848006702 G-X-G motif; other site 271848006703 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 271848006704 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848006705 active site 271848006706 phosphorylation site [posttranslational modification] 271848006707 intermolecular recognition site; other site 271848006708 dimerization interface [polypeptide binding]; other site 271848006709 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 271848006710 DNA binding residues [nucleotide binding] 271848006711 dimerization interface [polypeptide binding]; other site 271848006712 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 271848006713 Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C [Coenzyme metabolism]; Region: COG5424 271848006714 PAS domain; Region: PAS_9; pfam13426 271848006715 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271848006716 putative active site [active] 271848006717 heme pocket [chemical binding]; other site 271848006718 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 271848006719 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271848006720 metal binding site [ion binding]; metal-binding site 271848006721 active site 271848006722 I-site; other site 271848006723 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 271848006724 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 271848006725 Lipase (class 2); Region: Lipase_2; pfam01674 271848006726 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 271848006727 catalytic site [active] 271848006728 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 271848006729 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 271848006730 Domain of unknown function (DUF4345); Region: DUF4345; pfam14248 271848006731 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 271848006732 FtsX-like permease family; Region: FtsX; pfam02687 271848006733 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 271848006734 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 271848006735 Walker A/P-loop; other site 271848006736 ATP binding site [chemical binding]; other site 271848006737 Q-loop/lid; other site 271848006738 ABC transporter signature motif; other site 271848006739 Walker B; other site 271848006740 D-loop; other site 271848006741 H-loop/switch region; other site 271848006742 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 271848006743 Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743 271848006744 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 271848006745 Cytochrome P450; Region: p450; cl12078 271848006746 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 271848006747 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 271848006748 putative NADP binding site [chemical binding]; other site 271848006749 active site 271848006750 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 271848006751 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 271848006752 putative NAD(P) binding site [chemical binding]; other site 271848006753 active site 271848006754 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 271848006755 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 271848006756 active site 271848006757 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 271848006758 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 271848006759 active site 271848006760 active site 271848006761 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 271848006762 putative NADP binding site [chemical binding]; other site 271848006763 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 271848006764 active site 271848006765 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 271848006766 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 271848006767 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 271848006768 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 271848006769 VacJ like lipoprotein; Region: VacJ; cl01073 271848006770 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 271848006771 hypothetical protein; Provisional; Region: PRK07483 271848006772 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 271848006773 inhibitor-cofactor binding pocket; inhibition site 271848006774 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848006775 catalytic residue [active] 271848006776 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 271848006777 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 271848006778 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 271848006779 Walker A/P-loop; other site 271848006780 ATP binding site [chemical binding]; other site 271848006781 Q-loop/lid; other site 271848006782 ABC transporter signature motif; other site 271848006783 Walker B; other site 271848006784 D-loop; other site 271848006785 H-loop/switch region; other site 271848006786 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848006787 dimer interface [polypeptide binding]; other site 271848006788 conserved gate region; other site 271848006789 putative PBP binding loops; other site 271848006790 ABC-ATPase subunit interface; other site 271848006791 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 271848006792 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 271848006793 substrate binding pocket [chemical binding]; other site 271848006794 membrane-bound complex binding site; other site 271848006795 hinge residues; other site 271848006796 hypothetical protein; Provisional; Region: PRK07077 271848006797 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 271848006798 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 271848006799 Active site cavity [active] 271848006800 catalytic acid [active] 271848006801 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 271848006802 active site lid residues [active] 271848006803 substrate binding pocket [chemical binding]; other site 271848006804 catalytic residues [active] 271848006805 substrate-Mg2+ binding site; other site 271848006806 aspartate-rich region 1; other site 271848006807 aspartate-rich region 2; other site 271848006808 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 271848006809 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 271848006810 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 271848006811 PAS domain; Region: PAS; smart00091 271848006812 putative active site [active] 271848006813 heme pocket [chemical binding]; other site 271848006814 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 271848006815 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271848006816 metal binding site [ion binding]; metal-binding site 271848006817 active site 271848006818 I-site; other site 271848006819 Response regulator receiver domain; Region: Response_reg; pfam00072 271848006820 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848006821 active site 271848006822 phosphorylation site [posttranslational modification] 271848006823 intermolecular recognition site; other site 271848006824 dimerization interface [polypeptide binding]; other site 271848006825 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 271848006826 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271848006827 dimer interface [polypeptide binding]; other site 271848006828 phosphorylation site [posttranslational modification] 271848006829 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848006830 ATP binding site [chemical binding]; other site 271848006831 Mg2+ binding site [ion binding]; other site 271848006832 G-X-G motif; other site 271848006833 Response regulator receiver domain; Region: Response_reg; pfam00072 271848006834 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848006835 active site 271848006836 phosphorylation site [posttranslational modification] 271848006837 intermolecular recognition site; other site 271848006838 dimerization interface [polypeptide binding]; other site 271848006839 Predicted flavoprotein [General function prediction only]; Region: COG0431 271848006840 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 271848006841 RNA polymerase sigma factor; Provisional; Region: PRK12545 271848006842 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 271848006843 DNA binding residues [nucleotide binding] 271848006844 Putative zinc-finger; Region: zf-HC2; pfam13490 271848006845 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 271848006846 ArsC family; Region: ArsC; pfam03960 271848006847 catalytic residues [active] 271848006848 ParA-like protein; Provisional; Region: PHA02518 271848006849 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 271848006850 P-loop; other site 271848006851 Magnesium ion binding site [ion binding]; other site 271848006852 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 271848006853 ParB-like nuclease domain; Region: ParB; smart00470 271848006854 Initiator Replication protein; Region: Rep_3; pfam01051 271848006855 Burkholderia thailandensis E264 is an environmental isolate and the type strain of the species. It is available from the American Type Culture Collection, Mananass, VA. 271848006856 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 271848006857 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 271848006858 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 271848006859 Uncharacterized conserved protein [Function unknown]; Region: COG4121 271848006860 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 271848006861 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 271848006862 IHF dimer interface [polypeptide binding]; other site 271848006863 IHF - DNA interface [nucleotide binding]; other site 271848006864 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 271848006865 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 271848006866 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 271848006867 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 271848006868 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 271848006869 N-acetyl-D-glucosamine binding site [chemical binding]; other site 271848006870 catalytic residue [active] 271848006871 type II secretion system protein D; Region: type_II_gspD; TIGR02517 271848006872 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 271848006873 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 271848006874 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 271848006875 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 271848006876 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 271848006877 type II secretion system protein E; Region: type_II_gspE; TIGR02533 271848006878 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 271848006879 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 271848006880 Walker A motif; other site 271848006881 ATP binding site [chemical binding]; other site 271848006882 Walker B motif; other site 271848006883 type II secretion system protein F; Region: GspF; TIGR02120 271848006884 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 271848006885 Ceramidase; Region: Ceramidase; pfam05875 271848006886 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 271848006887 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 271848006888 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 271848006889 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 271848006890 type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708 271848006891 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 271848006892 Type II transport protein GspH; Region: GspH; pfam12019 271848006893 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 271848006894 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 271848006895 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 271848006896 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 271848006897 GspL periplasmic domain; Region: GspL_C; pfam12693 271848006898 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 271848006899 Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203 271848006900 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 271848006901 MarR family; Region: MarR_2; cl17246 271848006902 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 271848006903 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 271848006904 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848006905 putative substrate translocation pore; other site 271848006906 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848006907 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848006908 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848006909 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 271848006910 putative dimerization interface [polypeptide binding]; other site 271848006911 LrgA family; Region: LrgA; pfam03788 271848006912 LrgB-like family; Region: LrgB; cl00596 271848006913 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 271848006914 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 271848006915 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 271848006916 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 271848006917 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 271848006918 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 271848006919 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 271848006920 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 271848006921 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781 271848006922 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 271848006923 DNA binding residues [nucleotide binding] 271848006924 putative dimer interface [polypeptide binding]; other site 271848006925 putative metal binding residues [ion binding]; other site 271848006926 Methyltransferase domain; Region: Methyltransf_11; pfam08241 271848006927 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 271848006928 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 271848006929 membrane-bound complex binding site; other site 271848006930 hinge residues; other site 271848006931 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 271848006932 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 271848006933 Walker A/P-loop; other site 271848006934 ATP binding site [chemical binding]; other site 271848006935 Q-loop/lid; other site 271848006936 ABC transporter signature motif; other site 271848006937 Walker B; other site 271848006938 D-loop; other site 271848006939 H-loop/switch region; other site 271848006940 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 271848006941 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848006942 dimer interface [polypeptide binding]; other site 271848006943 conserved gate region; other site 271848006944 putative PBP binding loops; other site 271848006945 ABC-ATPase subunit interface; other site 271848006946 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 271848006947 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 271848006948 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 271848006949 dimer interface [polypeptide binding]; other site 271848006950 phosphorylation site [posttranslational modification] 271848006951 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848006952 ATP binding site [chemical binding]; other site 271848006953 Mg2+ binding site [ion binding]; other site 271848006954 G-X-G motif; other site 271848006955 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 271848006956 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848006957 active site 271848006958 phosphorylation site [posttranslational modification] 271848006959 intermolecular recognition site; other site 271848006960 dimerization interface [polypeptide binding]; other site 271848006961 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 271848006962 DNA binding site [nucleotide binding] 271848006963 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 271848006964 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 271848006965 trimer interface [polypeptide binding]; other site 271848006966 eyelet of channel; other site 271848006967 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 271848006968 DNA methylase; Region: N6_N4_Mtase; pfam01555 271848006969 DNA methylase; Region: N6_N4_Mtase; cl17433 271848006970 Restriction endonuclease [Defense mechanisms]; Region: COG3587 271848006971 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 271848006972 ATP binding site [chemical binding]; other site 271848006973 putative Mg++ binding site [ion binding]; other site 271848006974 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 271848006975 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 271848006976 trimer interface [polypeptide binding]; other site 271848006977 eyelet of channel; other site 271848006978 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 271848006979 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848006980 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 271848006981 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 271848006982 Walker A/P-loop; other site 271848006983 ATP binding site [chemical binding]; other site 271848006984 Q-loop/lid; other site 271848006985 ABC transporter signature motif; other site 271848006986 Walker B; other site 271848006987 D-loop; other site 271848006988 H-loop/switch region; other site 271848006989 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 271848006990 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 271848006991 Walker A/P-loop; other site 271848006992 ATP binding site [chemical binding]; other site 271848006993 Q-loop/lid; other site 271848006994 ABC transporter signature motif; other site 271848006995 Walker B; other site 271848006996 D-loop; other site 271848006997 H-loop/switch region; other site 271848006998 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 271848006999 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 271848007000 TM-ABC transporter signature motif; other site 271848007001 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 271848007002 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 271848007003 TM-ABC transporter signature motif; other site 271848007004 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 271848007005 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 271848007006 putative ligand binding site [chemical binding]; other site 271848007007 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 271848007008 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 271848007009 NAD(P) binding site [chemical binding]; other site 271848007010 catalytic residues [active] 271848007011 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 271848007012 Molybdenum cofactor biosynthesis protein F; Region: MoaF; pfam10703 271848007013 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 271848007014 classical (c) SDRs; Region: SDR_c; cd05233 271848007015 NAD(P) binding site [chemical binding]; other site 271848007016 active site 271848007017 choline dehydrogenase; Validated; Region: PRK02106 271848007018 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 271848007019 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 271848007020 Predicted transcriptional regulators [Transcription]; Region: COG1695 271848007021 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 271848007022 Predicted membrane protein [Function unknown]; Region: COG4709 271848007023 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 271848007024 Fatty acid desaturase; Region: FA_desaturase; pfam00487 271848007025 putative di-iron ligands [ion binding]; other site 271848007026 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 271848007027 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 271848007028 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 271848007029 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 271848007030 conserved cys residue [active] 271848007031 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 271848007032 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 271848007033 active site 271848007034 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 271848007035 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 271848007036 dimer interface [polypeptide binding]; other site 271848007037 active site 271848007038 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 271848007039 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 271848007040 substrate binding site [chemical binding]; other site 271848007041 oxyanion hole (OAH) forming residues; other site 271848007042 trimer interface [polypeptide binding]; other site 271848007043 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 271848007044 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 271848007045 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 271848007046 CoA-transferase family III; Region: CoA_transf_3; pfam02515 271848007047 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 271848007048 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 271848007049 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 271848007050 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 271848007051 DNA binding residues [nucleotide binding] 271848007052 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 271848007053 putative heme binding pocket [chemical binding]; other site 271848007054 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 271848007055 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 271848007056 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 271848007057 catalytic residues [active] 271848007058 catalytic nucleophile [active] 271848007059 Recombinase; Region: Recombinase; pfam07508 271848007060 ParB-like nuclease domain; Region: ParB; smart00470 271848007061 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 271848007062 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 271848007063 Transposase; Region: HTH_Tnp_1; pfam01527 271848007064 Domain of unknown function (DUF4382); Region: DUF4382; pfam14321 271848007065 transport protein sec23; Provisional; Region: PLN00162 271848007066 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 271848007067 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 271848007068 YaeQ protein; Region: YaeQ; pfam07152 271848007069 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 271848007070 dimer interface [polypeptide binding]; other site 271848007071 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 271848007072 metal binding site [ion binding]; metal-binding site 271848007073 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 271848007074 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 271848007075 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848007076 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848007077 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 271848007078 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 271848007079 DNA binding site [nucleotide binding] 271848007080 active site 271848007081 AlkA N-terminal domain; Region: AlkA_N; pfam06029 271848007082 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 271848007083 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 271848007084 minor groove reading motif; other site 271848007085 helix-hairpin-helix signature motif; other site 271848007086 substrate binding pocket [chemical binding]; other site 271848007087 active site 271848007088 glutamate--cysteine ligase; Provisional; Region: PRK02107 271848007089 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 271848007090 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 271848007091 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 271848007092 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 271848007093 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 271848007094 DNA binding residues [nucleotide binding] 271848007095 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 271848007096 dimer interface [polypeptide binding]; other site 271848007097 Phage-related protein [Function unknown]; Region: COG4695; cl01923 271848007098 Phage-related protein [Function unknown]; Region: COG4695; cl01923 271848007099 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 271848007100 active site 271848007101 DNA binding site [nucleotide binding] 271848007102 Int/Topo IB signature motif; other site 271848007103 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 271848007104 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 271848007105 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 271848007106 Magnesium ion binding site [ion binding]; other site 271848007107 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 271848007108 active site 271848007109 DNA binding site [nucleotide binding] 271848007110 Int/Topo IB signature motif; other site 271848007111 DNA topoisomerase 2; Provisional; Region: PLN03237 271848007112 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972 271848007113 Family description; Region: UvrD_C_2; pfam13538 271848007114 Uncharacterized conserved protein (DUF2290); Region: DUF2290; pfam10053 271848007115 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176 271848007116 putative homodimer interface [polypeptide binding]; other site 271848007117 putative active site [active] 271848007118 catalytic site [active] 271848007119 DEAD-like helicases superfamily; Region: DEXDc; smart00487 271848007120 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 271848007121 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 271848007122 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 271848007123 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 271848007124 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 271848007125 non-specific DNA binding site [nucleotide binding]; other site 271848007126 salt bridge; other site 271848007127 sequence-specific DNA binding site [nucleotide binding]; other site 271848007128 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 271848007129 phage/plasmid-like protein TIGR03299; Region: LGT_TIGR03299 271848007130 Predicted transcriptional regulator [Transcription]; Region: COG2378 271848007131 WYL domain; Region: WYL; pfam13280 271848007132 Nuclease-related domain; Region: NERD; pfam08378 271848007133 Catalytic domain of Protein Kinases; Region: PKc; cd00180 271848007134 active site 271848007135 ATP binding site [chemical binding]; other site 271848007136 substrate binding site [chemical binding]; other site 271848007137 activation loop (A-loop); other site 271848007138 Protein kinase domain; Region: Pkinase; pfam00069 271848007139 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 271848007140 active site 271848007141 ATP binding site [chemical binding]; other site 271848007142 substrate binding site [chemical binding]; other site 271848007143 activation loop (A-loop); other site 271848007144 PglZ domain; Region: PglZ; pfam08665 271848007145 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 271848007146 This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990 271848007147 PAAR motif; Region: PAAR_motif; pfam05488 271848007148 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 271848007149 CoenzymeA binding site [chemical binding]; other site 271848007150 subunit interaction site [polypeptide binding]; other site 271848007151 PHB binding site; other site 271848007152 Patatin-like phospholipase; Region: Patatin; pfam01734 271848007153 active site 271848007154 nucleophile elbow; other site 271848007155 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 271848007156 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 271848007157 dimerization interface [polypeptide binding]; other site 271848007158 NAD binding site [chemical binding]; other site 271848007159 ligand binding site [chemical binding]; other site 271848007160 catalytic site [active] 271848007161 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848007162 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848007163 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 271848007164 putative effector binding pocket; other site 271848007165 dimerization interface [polypeptide binding]; other site 271848007166 DNA topoisomerase III; Validated; Region: PRK08173 271848007167 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 271848007168 active site 271848007169 putative interdomain interaction site [polypeptide binding]; other site 271848007170 putative metal-binding site [ion binding]; other site 271848007171 putative nucleotide binding site [chemical binding]; other site 271848007172 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 271848007173 domain I; other site 271848007174 DNA binding groove [nucleotide binding] 271848007175 phosphate binding site [ion binding]; other site 271848007176 domain II; other site 271848007177 domain III; other site 271848007178 nucleotide binding site [chemical binding]; other site 271848007179 catalytic site [active] 271848007180 domain IV; other site 271848007181 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 271848007182 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 271848007183 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 271848007184 catalytic residues [active] 271848007185 DNA protecting protein DprA; Region: dprA; TIGR00732 271848007186 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 271848007187 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 271848007188 active site 271848007189 catalytic residues [active] 271848007190 metal binding site [ion binding]; metal-binding site 271848007191 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 271848007192 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 271848007193 putative active site [active] 271848007194 substrate binding site [chemical binding]; other site 271848007195 putative cosubstrate binding site; other site 271848007196 catalytic site [active] 271848007197 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 271848007198 substrate binding site [chemical binding]; other site 271848007199 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 271848007200 M48 family peptidase; Provisional; Region: PRK03001 271848007201 16S rRNA methyltransferase B; Provisional; Region: PRK10901 271848007202 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 271848007203 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848007204 S-adenosylmethionine binding site [chemical binding]; other site 271848007205 Domain of unknown function (DUF4390); Region: DUF4390; pfam14334 271848007206 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 271848007207 dimerization interface [polypeptide binding]; other site 271848007208 PAS domain; Region: PAS; smart00091 271848007209 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 271848007210 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271848007211 dimer interface [polypeptide binding]; other site 271848007212 phosphorylation site [posttranslational modification] 271848007213 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848007214 ATP binding site [chemical binding]; other site 271848007215 Mg2+ binding site [ion binding]; other site 271848007216 G-X-G motif; other site 271848007217 Response regulator receiver domain; Region: Response_reg; pfam00072 271848007218 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848007219 active site 271848007220 phosphorylation site [posttranslational modification] 271848007221 intermolecular recognition site; other site 271848007222 dimerization interface [polypeptide binding]; other site 271848007223 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 271848007224 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 271848007225 Ligand Binding Site [chemical binding]; other site 271848007226 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 271848007227 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 271848007228 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 271848007229 active site 271848007230 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 271848007231 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 271848007232 Sel1 repeat; Region: Sel1; cl02723 271848007233 Sel1-like repeats; Region: SEL1; smart00671 271848007234 Sel1-like repeats; Region: SEL1; smart00671 271848007235 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 271848007236 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 271848007237 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 271848007238 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 271848007239 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 271848007240 rod shape-determining protein MreC; Provisional; Region: PRK13922 271848007241 rod shape-determining protein MreC; Region: MreC; pfam04085 271848007242 rod shape-determining protein MreB; Provisional; Region: PRK13927 271848007243 MreB and similar proteins; Region: MreB_like; cd10225 271848007244 nucleotide binding site [chemical binding]; other site 271848007245 Mg binding site [ion binding]; other site 271848007246 putative protofilament interaction site [polypeptide binding]; other site 271848007247 RodZ interaction site [polypeptide binding]; other site 271848007248 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 271848007249 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 271848007250 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 271848007251 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 271848007252 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 271848007253 GatB domain; Region: GatB_Yqey; smart00845 271848007254 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 271848007255 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 271848007256 putative active site [active] 271848007257 putative catalytic site [active] 271848007258 putative DNA binding site [nucleotide binding]; other site 271848007259 putative phosphate binding site [ion binding]; other site 271848007260 metal binding site A [ion binding]; metal-binding site 271848007261 putative AP binding site [nucleotide binding]; other site 271848007262 putative metal binding site B [ion binding]; other site 271848007263 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 271848007264 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 271848007265 putative NAD(P) binding site [chemical binding]; other site 271848007266 putative substrate binding site [chemical binding]; other site 271848007267 catalytic Zn binding site [ion binding]; other site 271848007268 structural Zn binding site [ion binding]; other site 271848007269 dimer interface [polypeptide binding]; other site 271848007270 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 271848007271 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848007272 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 271848007273 Peptidase family M48; Region: Peptidase_M48; cl12018 271848007274 muropeptide transporter; Reviewed; Region: ampG; PRK11902 271848007275 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848007276 putative substrate translocation pore; other site 271848007277 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 271848007278 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 271848007279 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 271848007280 division inhibitor protein; Provisional; Region: slmA; PRK09480 271848007281 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 271848007282 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 271848007283 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 271848007284 motif II; other site 271848007285 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 271848007286 feedback inhibition sensing region; other site 271848007287 homohexameric interface [polypeptide binding]; other site 271848007288 nucleotide binding site [chemical binding]; other site 271848007289 N-acetyl-L-glutamate binding site [chemical binding]; other site 271848007290 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 271848007291 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 271848007292 dimer interface [polypeptide binding]; other site 271848007293 phosphorylation site [posttranslational modification] 271848007294 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848007295 ATP binding site [chemical binding]; other site 271848007296 Mg2+ binding site [ion binding]; other site 271848007297 G-X-G motif; other site 271848007298 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 271848007299 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848007300 active site 271848007301 phosphorylation site [posttranslational modification] 271848007302 intermolecular recognition site; other site 271848007303 dimerization interface [polypeptide binding]; other site 271848007304 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 271848007305 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 271848007306 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848007307 Walker A motif; other site 271848007308 ATP binding site [chemical binding]; other site 271848007309 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 271848007310 Walker B motif; other site 271848007311 arginine finger; other site 271848007312 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 271848007313 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 271848007314 active site 271848007315 HslU subunit interaction site [polypeptide binding]; other site 271848007316 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 271848007317 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 271848007318 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 271848007319 P-loop, Walker A motif; other site 271848007320 Base recognition motif; other site 271848007321 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 271848007322 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 271848007323 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 271848007324 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 271848007325 putative RNA binding site [nucleotide binding]; other site 271848007326 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848007327 S-adenosylmethionine binding site [chemical binding]; other site 271848007328 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 271848007329 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 271848007330 active site 271848007331 DNA binding site [nucleotide binding] 271848007332 Int/Topo IB signature motif; other site 271848007333 Protein of unknown function, DUF484; Region: DUF484; cl17449 271848007334 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 271848007335 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 271848007336 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 271848007337 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 271848007338 putative acyl-acceptor binding pocket; other site 271848007339 S-adenosylmethionine synthetase; Validated; Region: PRK05250 271848007340 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 271848007341 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 271848007342 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 271848007343 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 271848007344 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 271848007345 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 271848007346 active site 271848007347 catalytic tetrad [active] 271848007348 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848007349 putative substrate translocation pore; other site 271848007350 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 271848007351 serine/threonine protein kinase; Provisional; Region: PRK11768 271848007352 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 271848007353 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 271848007354 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848007355 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_1; cd08447 271848007356 putative dimerization interface [polypeptide binding]; other site 271848007357 putative substrate binding pocket [chemical binding]; other site 271848007358 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 271848007359 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 271848007360 putative active site [active] 271848007361 catalytic residue [active] 271848007362 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 271848007363 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 271848007364 dimer interface [polypeptide binding]; other site 271848007365 NADP binding site [chemical binding]; other site 271848007366 catalytic residues [active] 271848007367 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848007368 D-galactonate transporter; Region: 2A0114; TIGR00893 271848007369 putative substrate translocation pore; other site 271848007370 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848007371 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 271848007372 substrate binding pocket [chemical binding]; other site 271848007373 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 271848007374 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 271848007375 active site 271848007376 tetramer interface [polypeptide binding]; other site 271848007377 galactarate dehydratase; Region: galactar-dH20; TIGR03248 271848007378 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 271848007379 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 271848007380 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 271848007381 extended (e) SDRs; Region: SDR_e; cd08946 271848007382 NAD(P) binding site [chemical binding]; other site 271848007383 active site 271848007384 substrate binding site [chemical binding]; other site 271848007385 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 271848007386 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 271848007387 NAD(P) binding site [chemical binding]; other site 271848007388 catalytic residues [active] 271848007389 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 271848007390 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 271848007391 active site 271848007392 choline dehydrogenase; Validated; Region: PRK02106 271848007393 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 271848007394 Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777 271848007395 Flagellar FliJ protein; Region: FliJ; pfam02050 271848007396 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 271848007397 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 271848007398 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 271848007399 Walker A motif/ATP binding site; other site 271848007400 Walker B motif; other site 271848007401 flagellar assembly protein H; Validated; Region: fliH; PRK05687 271848007402 Flagellar assembly protein FliH; Region: FliH; pfam02108 271848007403 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 271848007404 FliG C-terminal domain; Region: FliG_C; pfam01706 271848007405 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 271848007406 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 271848007407 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 271848007408 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 271848007409 Flagellar protein FliS; Region: FliS; cl00654 271848007410 Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777 271848007411 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 271848007412 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295 271848007413 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 271848007414 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 271848007415 XdhC Rossmann domain; Region: XdhC_C; pfam13478 271848007416 amino acid transporter; Region: 2A0306; TIGR00909 271848007417 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 271848007418 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 271848007419 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848007420 active site 271848007421 phosphorylation site [posttranslational modification] 271848007422 intermolecular recognition site; other site 271848007423 dimerization interface [polypeptide binding]; other site 271848007424 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 271848007425 DNA binding residues [nucleotide binding] 271848007426 dimerization interface [polypeptide binding]; other site 271848007427 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 271848007428 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848007429 ATP binding site [chemical binding]; other site 271848007430 G-X-G motif; other site 271848007431 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 271848007432 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 271848007433 FAD binding pocket [chemical binding]; other site 271848007434 FAD binding motif [chemical binding]; other site 271848007435 phosphate binding motif [ion binding]; other site 271848007436 beta-alpha-beta structure motif; other site 271848007437 NAD binding pocket [chemical binding]; other site 271848007438 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 271848007439 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 271848007440 putative catalytic site [active] 271848007441 putative phosphate binding site [ion binding]; other site 271848007442 putative metal binding site [ion binding]; other site 271848007443 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848007444 Walker A motif; other site 271848007445 ATP binding site [chemical binding]; other site 271848007446 Walker B motif; other site 271848007447 arginine finger; other site 271848007448 Predicted dehydrogenase [General function prediction only]; Region: COG0579 271848007449 hydroxyglutarate oxidase; Provisional; Region: PRK11728 271848007450 High potential iron-sulfur protein; Region: HIPIP; pfam01355 271848007451 citrate-proton symporter; Provisional; Region: PRK15075 271848007452 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848007453 putative substrate translocation pore; other site 271848007454 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 271848007455 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 271848007456 peptide binding site [polypeptide binding]; other site 271848007457 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 271848007458 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848007459 dimer interface [polypeptide binding]; other site 271848007460 conserved gate region; other site 271848007461 putative PBP binding loops; other site 271848007462 ABC-ATPase subunit interface; other site 271848007463 dipeptide transporter; Provisional; Region: PRK10913 271848007464 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848007465 dimer interface [polypeptide binding]; other site 271848007466 conserved gate region; other site 271848007467 putative PBP binding loops; other site 271848007468 ABC-ATPase subunit interface; other site 271848007469 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 271848007470 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 271848007471 Walker A/P-loop; other site 271848007472 ATP binding site [chemical binding]; other site 271848007473 Q-loop/lid; other site 271848007474 ABC transporter signature motif; other site 271848007475 Walker B; other site 271848007476 D-loop; other site 271848007477 H-loop/switch region; other site 271848007478 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 271848007479 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 271848007480 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 271848007481 Walker A/P-loop; other site 271848007482 ATP binding site [chemical binding]; other site 271848007483 Q-loop/lid; other site 271848007484 ABC transporter signature motif; other site 271848007485 Walker B; other site 271848007486 D-loop; other site 271848007487 H-loop/switch region; other site 271848007488 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 271848007489 TraB family; Region: TraB; pfam01963 271848007490 Predicted membrane protein [Function unknown]; Region: COG3817 271848007491 Protein of unknown function (DUF979); Region: DUF979; pfam06166 271848007492 Protein of unknown function (DUF969); Region: DUF969; pfam06149 271848007493 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 271848007494 putative active site [active] 271848007495 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 271848007496 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 271848007497 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 271848007498 MarR family; Region: MarR_2; cl17246 271848007499 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 271848007500 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 271848007501 lytic murein transglycosylase; Provisional; Region: PRK11619 271848007502 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 271848007503 N-acetyl-D-glucosamine binding site [chemical binding]; other site 271848007504 catalytic residue [active] 271848007505 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 271848007506 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 271848007507 putative NAD(P) binding site [chemical binding]; other site 271848007508 active site 271848007509 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 271848007510 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 271848007511 putative C-terminal domain interface [polypeptide binding]; other site 271848007512 putative GSH binding site (G-site) [chemical binding]; other site 271848007513 putative dimer interface [polypeptide binding]; other site 271848007514 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 271848007515 putative N-terminal domain interface [polypeptide binding]; other site 271848007516 putative dimer interface [polypeptide binding]; other site 271848007517 putative substrate binding pocket (H-site) [chemical binding]; other site 271848007518 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 271848007519 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 271848007520 active site 271848007521 NTP binding site [chemical binding]; other site 271848007522 metal binding triad [ion binding]; metal-binding site 271848007523 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 271848007524 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503 271848007525 FlgN protein; Region: FlgN; pfam05130 271848007526 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 271848007527 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 271848007528 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 271848007529 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12626 271848007530 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 271848007531 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 271848007532 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 271848007533 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 271848007534 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 271848007535 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 271848007536 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 271848007537 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 271848007538 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 271848007539 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 271848007540 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 271848007541 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 271848007542 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 271848007543 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 271848007544 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12694 271848007545 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 271848007546 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 271848007547 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12697 271848007548 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 271848007549 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 271848007550 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 271848007551 flagellar rod assembly protein/muramidase FlgJ; Provisional; Region: flgJ; PRK12709 271848007552 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 271848007553 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 271848007554 Flagellar regulator YcgR; Region: YcgR; pfam07317 271848007555 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 271848007556 PilZ domain; Region: PilZ; pfam07238 271848007557 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06945 271848007558 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 271848007559 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 271848007560 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 271848007561 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 271848007562 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 271848007563 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848007564 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 271848007565 dimerization interface [polypeptide binding]; other site 271848007566 substrate binding pocket [chemical binding]; other site 271848007567 Chromate transporter; Region: Chromate_transp; pfam02417 271848007568 Chromate transporter; Region: Chromate_transp; pfam02417 271848007569 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 271848007570 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 271848007571 PhnA protein; Region: PhnA; pfam03831 271848007572 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 271848007573 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 271848007574 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 271848007575 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 271848007576 trimer interface [polypeptide binding]; other site 271848007577 eyelet of channel; other site 271848007578 putative membrane protein; Region: HpnL; TIGR03476 271848007579 hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472 271848007580 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 271848007581 ligand binding site; other site 271848007582 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 271848007583 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 271848007584 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 271848007585 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 271848007586 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 271848007587 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 271848007588 glutathione reductase; Validated; Region: PRK06116 271848007589 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 271848007590 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 271848007591 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 271848007592 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 271848007593 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 271848007594 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848007595 active site 271848007596 phosphorylation site [posttranslational modification] 271848007597 intermolecular recognition site; other site 271848007598 dimerization interface [polypeptide binding]; other site 271848007599 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 271848007600 DNA binding site [nucleotide binding] 271848007601 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 271848007602 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 271848007603 dimerization interface [polypeptide binding]; other site 271848007604 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848007605 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 271848007606 putative effector binding pocket; other site 271848007607 dimerization interface [polypeptide binding]; other site 271848007608 argininosuccinate synthase; Validated; Region: PRK05370 271848007609 argininosuccinate synthase; Provisional; Region: PRK13820 271848007610 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 271848007611 metal-binding site [ion binding] 271848007612 YHS domain; Region: YHS; pfam04945 271848007613 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 271848007614 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 271848007615 Soluble P-type ATPase [General function prediction only]; Region: COG4087 271848007616 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 271848007617 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 271848007618 Repair protein; Region: Repair_PSII; pfam04536 271848007619 Repair protein; Region: Repair_PSII; pfam04536 271848007620 Avidin family; Region: Avidin; pfam01382 271848007621 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 271848007622 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 271848007623 glutaminase active site [active] 271848007624 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 271848007625 dimer interface [polypeptide binding]; other site 271848007626 active site 271848007627 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 271848007628 dimer interface [polypeptide binding]; other site 271848007629 active site 271848007630 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 271848007631 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 271848007632 Substrate binding site; other site 271848007633 Mg++ binding site; other site 271848007634 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 271848007635 active site 271848007636 substrate binding site [chemical binding]; other site 271848007637 CoA binding site [chemical binding]; other site 271848007638 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 271848007639 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 271848007640 Ligand Binding Site [chemical binding]; other site 271848007641 Dihydroneopterin aldolase; Region: FolB; smart00905 271848007642 active site 271848007643 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848007644 active site 271848007645 Uncharacterized conserved protein [Function unknown]; Region: COG1565 271848007646 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 271848007647 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 271848007648 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 271848007649 putative substrate binding site [chemical binding]; other site 271848007650 putative ATP binding site [chemical binding]; other site 271848007651 dimerization interface [polypeptide binding]; other site 271848007652 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221 271848007653 putative active cleft [active] 271848007654 Transcriptional regulators [Transcription]; Region: PurR; COG1609 271848007655 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 271848007656 DNA binding site [nucleotide binding] 271848007657 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 271848007658 ligand binding site [chemical binding]; other site 271848007659 dimerization interface [polypeptide binding]; other site 271848007660 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 271848007661 dimer interface [polypeptide binding]; other site 271848007662 putative CheW interface [polypeptide binding]; other site 271848007663 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 271848007664 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 271848007665 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 271848007666 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 271848007667 trimer interface [polypeptide binding]; other site 271848007668 eyelet of channel; other site 271848007669 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848007670 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848007671 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 271848007672 putative effector binding pocket; other site 271848007673 dimerization interface [polypeptide binding]; other site 271848007674 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 271848007675 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 271848007676 FMN binding site [chemical binding]; other site 271848007677 substrate binding site [chemical binding]; other site 271848007678 putative catalytic residue [active] 271848007679 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 271848007680 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 271848007681 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 271848007682 putative DNA binding site [nucleotide binding]; other site 271848007683 putative Zn2+ binding site [ion binding]; other site 271848007684 AsnC family; Region: AsnC_trans_reg; pfam01037 271848007685 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 271848007686 EamA-like transporter family; Region: EamA; pfam00892 271848007687 EamA-like transporter family; Region: EamA; pfam00892 271848007688 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 271848007689 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 271848007690 putative deacylase active site [active] 271848007691 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 271848007692 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 271848007693 active site 271848007694 catalytic residues [active] 271848007695 metal binding site [ion binding]; metal-binding site 271848007696 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 271848007697 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 271848007698 putative ligand binding site [chemical binding]; other site 271848007699 NAD binding site [chemical binding]; other site 271848007700 dimerization interface [polypeptide binding]; other site 271848007701 catalytic site [active] 271848007702 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 271848007703 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 271848007704 putative metal binding site [ion binding]; other site 271848007705 Serine hydrolase; Region: Ser_hydrolase; pfam06821 271848007706 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 271848007707 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 271848007708 Phosphoesterase family; Region: Phosphoesterase; pfam04185 271848007709 Domain of unknown function (DUF756); Region: DUF756; pfam05506 271848007710 Domain of unknown function (DUF756); Region: DUF756; pfam05506 271848007711 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 271848007712 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 271848007713 putative DNA binding site [nucleotide binding]; other site 271848007714 putative Zn2+ binding site [ion binding]; other site 271848007715 AsnC family; Region: AsnC_trans_reg; pfam01037 271848007716 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 271848007717 Predicted membrane protein [Function unknown]; Region: COG4541 271848007718 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 271848007719 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 271848007720 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 271848007721 dimer interface [polypeptide binding]; other site 271848007722 active site 271848007723 catalytic residue [active] 271848007724 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 271848007725 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 271848007726 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 271848007727 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 271848007728 Inward rectifier potassium channel; Region: IRK; pfam01007 271848007729 2-oxoacid ferredoxin oxidoreductase; Provisional; Region: PRK13030 271848007730 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 271848007731 dimer interface [polypeptide binding]; other site 271848007732 PYR/PP interface [polypeptide binding]; other site 271848007733 TPP binding site [chemical binding]; other site 271848007734 substrate binding site [chemical binding]; other site 271848007735 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 271848007736 TPP-binding site; other site 271848007737 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 271848007738 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 271848007739 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 271848007740 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 271848007741 glycoprotein BALF4; Provisional; Region: PHA03231 271848007742 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 271848007743 Alkaline phosphatase homologues; Region: alkPPc; smart00098 271848007744 active site 271848007745 dimer interface [polypeptide binding]; other site 271848007746 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 271848007747 Alkaline phosphatase homologues; Region: alkPPc; smart00098 271848007748 active site 271848007749 dimer interface [polypeptide binding]; other site 271848007750 CutC family; Region: CutC; cl01218 271848007751 biotin synthase; Region: bioB; TIGR00433 271848007752 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 271848007753 FeS/SAM binding site; other site 271848007754 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 271848007755 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 271848007756 AAA domain; Region: AAA_26; pfam13500 271848007757 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 271848007758 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 271848007759 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 271848007760 catalytic residue [active] 271848007761 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06943 271848007762 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 271848007763 inhibitor-cofactor binding pocket; inhibition site 271848007764 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848007765 catalytic residue [active] 271848007766 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 271848007767 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 271848007768 hypothetical protein; Provisional; Region: PRK01842 271848007769 short chain dehydrogenase; Provisional; Region: PRK06953 271848007770 C factor cell-cell signaling protein; Provisional; Region: PRK09009 271848007771 NAD(P) binding site [chemical binding]; other site 271848007772 active site 271848007773 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 271848007774 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 271848007775 dimer interface [polypeptide binding]; other site 271848007776 active site 271848007777 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 271848007778 active site clefts [active] 271848007779 zinc binding site [ion binding]; other site 271848007780 dimer interface [polypeptide binding]; other site 271848007781 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 271848007782 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 271848007783 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 271848007784 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 271848007785 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 271848007786 Walker A/P-loop; other site 271848007787 ATP binding site [chemical binding]; other site 271848007788 Q-loop/lid; other site 271848007789 ABC transporter signature motif; other site 271848007790 Walker B; other site 271848007791 D-loop; other site 271848007792 H-loop/switch region; other site 271848007793 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 271848007794 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 271848007795 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 271848007796 peptide binding site [polypeptide binding]; other site 271848007797 MarR family; Region: MarR_2; cl17246 271848007798 Transcriptional regulators [Transcription]; Region: MarR; COG1846 271848007799 short chain dehydrogenase; Validated; Region: PRK08264 271848007800 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848007801 NAD(P) binding site [chemical binding]; other site 271848007802 active site 271848007803 short chain dehydrogenase; Provisional; Region: PRK07024 271848007804 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848007805 NAD(P) binding site [chemical binding]; other site 271848007806 active site 271848007807 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 271848007808 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 271848007809 catalytic residues [active] 271848007810 hinge region; other site 271848007811 alpha helical domain; other site 271848007812 Sporulation related domain; Region: SPOR; pfam05036 271848007813 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 271848007814 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 271848007815 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 271848007816 active site 271848007817 HIGH motif; other site 271848007818 KMSK motif region; other site 271848007819 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 271848007820 tRNA binding surface [nucleotide binding]; other site 271848007821 anticodon binding site; other site 271848007822 Domain of unknown function (DUF1840); Region: DUF1840; pfam08895 271848007823 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 271848007824 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 271848007825 substrate binding pocket [chemical binding]; other site 271848007826 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 271848007827 B12 binding site [chemical binding]; other site 271848007828 cobalt ligand [ion binding]; other site 271848007829 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 271848007830 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 271848007831 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 271848007832 Protein of unknown function (DUF3567); Region: DUF3567; pfam12091 271848007833 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 271848007834 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 271848007835 Transcriptional regulator [Transcription]; Region: IclR; COG1414 271848007836 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 271848007837 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 271848007838 enoyl-CoA hydratase; Provisional; Region: PRK07657 271848007839 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 271848007840 substrate binding site [chemical binding]; other site 271848007841 oxyanion hole (OAH) forming residues; other site 271848007842 trimer interface [polypeptide binding]; other site 271848007843 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 271848007844 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 271848007845 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 271848007846 active site 271848007847 nucleophile elbow; other site 271848007848 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 271848007849 dinuclear metal binding motif [ion binding]; other site 271848007850 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 271848007851 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 271848007852 active site 271848007853 HIGH motif; other site 271848007854 nucleotide binding site [chemical binding]; other site 271848007855 pantothenate kinase; Reviewed; Region: PRK13328 271848007856 biotin--protein ligase; Provisional; Region: PRK06955 271848007857 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 271848007858 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 271848007859 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 271848007860 Sel1-like repeats; Region: SEL1; smart00671 271848007861 Sel1-like repeats; Region: SEL1; smart00671 271848007862 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 271848007863 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 271848007864 active site 271848007865 metal binding site [ion binding]; metal-binding site 271848007866 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 271848007867 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 271848007868 Permease; Region: Permease; pfam02405 271848007869 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 271848007870 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 271848007871 Walker A/P-loop; other site 271848007872 ATP binding site [chemical binding]; other site 271848007873 Q-loop/lid; other site 271848007874 ABC transporter signature motif; other site 271848007875 Walker B; other site 271848007876 D-loop; other site 271848007877 H-loop/switch region; other site 271848007878 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 271848007879 mce related protein; Region: MCE; pfam02470 271848007880 Protein of unknown function (DUF330); Region: DUF330; pfam03886 271848007881 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 271848007882 dimer interface [polypeptide binding]; other site 271848007883 [2Fe-2S] cluster binding site [ion binding]; other site 271848007884 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 271848007885 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 271848007886 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 271848007887 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 271848007888 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 271848007889 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 271848007890 homodimer interface [polypeptide binding]; other site 271848007891 substrate-cofactor binding pocket; other site 271848007892 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848007893 catalytic residue [active] 271848007894 hypothetical protein; Provisional; Region: PRK02047 271848007895 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 271848007896 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848007897 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 271848007898 dimerization interface [polypeptide binding]; other site 271848007899 substrate binding pocket [chemical binding]; other site 271848007900 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 271848007901 lipoate-protein ligase B; Provisional; Region: PRK14343 271848007902 lipoyl synthase; Provisional; Region: PRK05481 271848007903 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 271848007904 FeS/SAM binding site; other site 271848007905 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 271848007906 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 271848007907 putative NAD(P) binding site [chemical binding]; other site 271848007908 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848007909 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 271848007910 putative effector binding pocket; other site 271848007911 putative dimerization interface [polypeptide binding]; other site 271848007912 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 271848007913 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 271848007914 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848007915 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848007916 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 271848007917 putative effector binding pocket; other site 271848007918 dimerization interface [polypeptide binding]; other site 271848007919 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 271848007920 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 271848007921 substrate binding site [chemical binding]; other site 271848007922 oxyanion hole (OAH) forming residues; other site 271848007923 trimer interface [polypeptide binding]; other site 271848007924 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 271848007925 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 271848007926 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 271848007927 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 271848007928 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 271848007929 active site 271848007930 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 271848007931 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 271848007932 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 271848007933 active site 271848007934 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 271848007935 CoA-transferase family III; Region: CoA_transf_3; pfam02515 271848007936 Protein of unknown function, DUF485; Region: DUF485; pfam04341 271848007937 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 271848007938 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 271848007939 Na binding site [ion binding]; other site 271848007940 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 271848007941 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 271848007942 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 271848007943 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271848007944 dimer interface [polypeptide binding]; other site 271848007945 phosphorylation site [posttranslational modification] 271848007946 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848007947 ATP binding site [chemical binding]; other site 271848007948 Mg2+ binding site [ion binding]; other site 271848007949 G-X-G motif; other site 271848007950 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 271848007951 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848007952 active site 271848007953 phosphorylation site [posttranslational modification] 271848007954 intermolecular recognition site; other site 271848007955 dimerization interface [polypeptide binding]; other site 271848007956 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848007957 Walker A motif; other site 271848007958 ATP binding site [chemical binding]; other site 271848007959 Walker B motif; other site 271848007960 arginine finger; other site 271848007961 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 271848007962 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 271848007963 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 271848007964 catalytic residues [active] 271848007965 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 271848007966 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 271848007967 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 271848007968 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 271848007969 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 271848007970 Membrane fusogenic activity; Region: BMFP; pfam04380 271848007971 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 271848007972 Nitrogen regulatory protein P-II; Region: P-II; smart00938 271848007973 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 271848007974 glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049 271848007975 Glutamate-cysteine ligase; Region: GshA; pfam08886 271848007976 glutathione synthetase; Provisional; Region: PRK05246 271848007977 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 271848007978 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 271848007979 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 271848007980 active pocket/dimerization site; other site 271848007981 active site 271848007982 phosphorylation site [posttranslational modification] 271848007983 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 271848007984 dimerization domain swap beta strand [polypeptide binding]; other site 271848007985 regulatory protein interface [polypeptide binding]; other site 271848007986 active site 271848007987 regulatory phosphorylation site [posttranslational modification]; other site 271848007988 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 271848007989 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 271848007990 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 271848007991 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 271848007992 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 271848007993 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 271848007994 ATP binding site [chemical binding]; other site 271848007995 substrate interface [chemical binding]; other site 271848007996 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 271848007997 C-terminal peptidase (prc); Region: prc; TIGR00225 271848007998 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 271848007999 protein binding site [polypeptide binding]; other site 271848008000 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 271848008001 Catalytic dyad [active] 271848008002 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 271848008003 catalytic core [active] 271848008004 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 271848008005 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 271848008006 active site residue [active] 271848008007 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 271848008008 GSH binding site [chemical binding]; other site 271848008009 catalytic residues [active] 271848008010 preprotein translocase subunit SecB; Validated; Region: PRK05751 271848008011 SecA binding site; other site 271848008012 Preprotein binding site; other site 271848008013 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 271848008014 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 271848008015 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 271848008016 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 271848008017 putative ADP-ribose binding site [chemical binding]; other site 271848008018 putative active site [active] 271848008019 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 271848008020 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 271848008021 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 271848008022 active site 271848008023 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 271848008024 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848008025 S-adenosylmethionine binding site [chemical binding]; other site 271848008026 Integral membrane protein (DUF2244); Region: DUF2244; pfam10003 271848008027 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 271848008028 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140 271848008029 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 271848008030 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 271848008031 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 271848008032 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 271848008033 ligand binding site [chemical binding]; other site 271848008034 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 271848008035 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 271848008036 Subunit I/III interface [polypeptide binding]; other site 271848008037 D-pathway; other site 271848008038 Subunit I/VIIc interface [polypeptide binding]; other site 271848008039 Subunit I/IV interface [polypeptide binding]; other site 271848008040 Subunit I/II interface [polypeptide binding]; other site 271848008041 Low-spin heme (heme a) binding site [chemical binding]; other site 271848008042 Subunit I/VIIa interface [polypeptide binding]; other site 271848008043 Subunit I/VIa interface [polypeptide binding]; other site 271848008044 Dimer interface; other site 271848008045 Putative water exit pathway; other site 271848008046 Binuclear center (heme a3/CuB) [ion binding]; other site 271848008047 K-pathway; other site 271848008048 Subunit I/Vb interface [polypeptide binding]; other site 271848008049 Putative proton exit pathway; other site 271848008050 Subunit I/VIb interface; other site 271848008051 Subunit I/VIc interface [polypeptide binding]; other site 271848008052 Electron transfer pathway; other site 271848008053 Subunit I/VIIIb interface [polypeptide binding]; other site 271848008054 Subunit I/VIIb interface [polypeptide binding]; other site 271848008055 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 271848008056 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 271848008057 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 271848008058 Subunit III/VIIa interface [polypeptide binding]; other site 271848008059 Phospholipid binding site [chemical binding]; other site 271848008060 Subunit I/III interface [polypeptide binding]; other site 271848008061 Subunit III/VIb interface [polypeptide binding]; other site 271848008062 Subunit III/VIa interface; other site 271848008063 Subunit III/Vb interface [polypeptide binding]; other site 271848008064 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 271848008065 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 271848008066 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 271848008067 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 271848008068 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 271848008069 UbiA prenyltransferase family; Region: UbiA; pfam01040 271848008070 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 271848008071 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 271848008072 Cu(I) binding site [ion binding]; other site 271848008073 YCII-related domain; Region: YCII; cl00999 271848008074 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 271848008075 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 271848008076 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 271848008077 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 271848008078 dimer interface [polypeptide binding]; other site 271848008079 putative CheW interface [polypeptide binding]; other site 271848008080 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 271848008081 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 271848008082 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 271848008083 zinc binding site [ion binding]; other site 271848008084 putative ligand binding site [chemical binding]; other site 271848008085 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 271848008086 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 271848008087 TM-ABC transporter signature motif; other site 271848008088 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 271848008089 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 271848008090 Walker A/P-loop; other site 271848008091 ATP binding site [chemical binding]; other site 271848008092 Q-loop/lid; other site 271848008093 ABC transporter signature motif; other site 271848008094 Walker B; other site 271848008095 D-loop; other site 271848008096 H-loop/switch region; other site 271848008097 DNA Polymerase Y-family; Region: PolY_like; cd03468 271848008098 active site 271848008099 DNA binding site [nucleotide binding] 271848008100 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 271848008101 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 271848008102 putative active site [active] 271848008103 putative PHP Thumb interface [polypeptide binding]; other site 271848008104 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 271848008105 generic binding surface II; other site 271848008106 generic binding surface I; other site 271848008107 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 271848008108 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 271848008109 DNA-binding site [nucleotide binding]; DNA binding site 271848008110 UTRA domain; Region: UTRA; pfam07702 271848008111 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 271848008112 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 271848008113 active site 271848008114 dimer interface [polypeptide binding]; other site 271848008115 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 271848008116 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 271848008117 dimer interface [polypeptide binding]; other site 271848008118 active site 271848008119 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 271848008120 dimer interface [polypeptide binding]; other site 271848008121 active site 271848008122 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 271848008123 HPr interaction site; other site 271848008124 glycerol kinase (GK) interaction site [polypeptide binding]; other site 271848008125 active site 271848008126 phosphorylation site [posttranslational modification] 271848008127 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 271848008128 dimerization domain swap beta strand [polypeptide binding]; other site 271848008129 regulatory protein interface [polypeptide binding]; other site 271848008130 active site 271848008131 regulatory phosphorylation site [posttranslational modification]; other site 271848008132 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 271848008133 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 271848008134 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 271848008135 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 271848008136 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 271848008137 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 271848008138 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 271848008139 active site turn [active] 271848008140 phosphorylation site [posttranslational modification] 271848008141 Putative carbohydrate binding domain; Region: CHB_HEX; smart01081 271848008142 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 271848008143 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 271848008144 active site 271848008145 Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173 271848008146 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 271848008147 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 271848008148 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 271848008149 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 271848008150 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 271848008151 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 271848008152 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 271848008153 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 271848008154 DNA binding residues [nucleotide binding] 271848008155 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 271848008156 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 271848008157 SnoaL-like domain; Region: SnoaL_3; pfam13474 271848008158 2-isopropylmalate synthase; Validated; Region: PRK03739 271848008159 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 271848008160 active site 271848008161 catalytic residues [active] 271848008162 metal binding site [ion binding]; metal-binding site 271848008163 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 271848008164 Coenzyme A binding pocket [chemical binding]; other site 271848008165 glycosyl transferase family protein; Provisional; Region: PRK08136 271848008166 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 271848008167 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 271848008168 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 271848008169 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 271848008170 molybdopterin cofactor binding site; other site 271848008171 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 271848008172 molybdopterin cofactor binding site; other site 271848008173 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 271848008174 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 271848008175 [2Fe-2S] cluster binding site [ion binding]; other site 271848008176 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 271848008177 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 271848008178 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 271848008179 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 271848008180 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 271848008181 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 271848008182 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 271848008183 C-terminal domain interface [polypeptide binding]; other site 271848008184 GSH binding site (G-site) [chemical binding]; other site 271848008185 putative dimer interface [polypeptide binding]; other site 271848008186 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 271848008187 dimer interface [polypeptide binding]; other site 271848008188 N-terminal domain interface [polypeptide binding]; other site 271848008189 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 271848008190 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 271848008191 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 271848008192 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 271848008193 P loop; other site 271848008194 GTP binding site [chemical binding]; other site 271848008195 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 271848008196 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848008197 S-adenosylmethionine binding site [chemical binding]; other site 271848008198 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 271848008199 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 271848008200 active site 271848008201 (T/H)XGH motif; other site 271848008202 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 271848008203 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 271848008204 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 271848008205 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848008206 homodimer interface [polypeptide binding]; other site 271848008207 catalytic residue [active] 271848008208 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 271848008209 putative active site [active] 271848008210 catalytic residue [active] 271848008211 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 271848008212 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 271848008213 5S rRNA interface [nucleotide binding]; other site 271848008214 CTC domain interface [polypeptide binding]; other site 271848008215 L16 interface [polypeptide binding]; other site 271848008216 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 271848008217 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 271848008218 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 271848008219 active site 271848008220 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 271848008221 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 271848008222 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 271848008223 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 271848008224 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 271848008225 binding surface 271848008226 TPR motif; other site 271848008227 TPR repeat; Region: TPR_11; pfam13414 271848008228 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 271848008229 binding surface 271848008230 TPR motif; other site 271848008231 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 271848008232 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 271848008233 DNA binding site [nucleotide binding] 271848008234 catalytic residue [active] 271848008235 H2TH interface [polypeptide binding]; other site 271848008236 putative catalytic residues [active] 271848008237 turnover-facilitating residue; other site 271848008238 intercalation triad [nucleotide binding]; other site 271848008239 8OG recognition residue [nucleotide binding]; other site 271848008240 putative reading head residues; other site 271848008241 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 271848008242 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 271848008243 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 271848008244 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 271848008245 minor groove reading motif; other site 271848008246 helix-hairpin-helix signature motif; other site 271848008247 substrate binding pocket [chemical binding]; other site 271848008248 active site 271848008249 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 271848008250 DNA binding and oxoG recognition site [nucleotide binding] 271848008251 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 271848008252 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 271848008253 HPr kinase/phosphorylase; Provisional; Region: PRK05428 271848008254 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 271848008255 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 271848008256 Hpr binding site; other site 271848008257 active site 271848008258 homohexamer subunit interaction site [polypeptide binding]; other site 271848008259 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 271848008260 active site 271848008261 phosphorylation site [posttranslational modification] 271848008262 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 271848008263 30S subunit binding site; other site 271848008264 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 271848008265 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 271848008266 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 271848008267 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 271848008268 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 271848008269 Walker A/P-loop; other site 271848008270 ATP binding site [chemical binding]; other site 271848008271 Q-loop/lid; other site 271848008272 ABC transporter signature motif; other site 271848008273 Walker B; other site 271848008274 D-loop; other site 271848008275 H-loop/switch region; other site 271848008276 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 271848008277 OstA-like protein; Region: OstA; pfam03968 271848008278 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117 271848008279 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 271848008280 Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778 271848008281 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 271848008282 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 271848008283 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 271848008284 putative active site [active] 271848008285 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 271848008286 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 271848008287 putative cation:proton antiport protein; Provisional; Region: PRK10669 271848008288 TrkA-N domain; Region: TrkA_N; pfam02254 271848008289 TrkA-C domain; Region: TrkA_C; pfam02080 271848008290 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 271848008291 active site 271848008292 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 271848008293 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belong to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_hydrolase_3; cd03676 271848008294 nudix motif; other site 271848008295 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 271848008296 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 271848008297 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 271848008298 putative active site [active] 271848008299 putative substrate binding site [chemical binding]; other site 271848008300 putative cosubstrate binding site; other site 271848008301 catalytic site [active] 271848008302 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 271848008303 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 271848008304 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 271848008305 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 271848008306 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 271848008307 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848008308 Major Facilitator Superfamily; Region: MFS_1; pfam07690 271848008309 putative substrate translocation pore; other site 271848008310 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 271848008311 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 271848008312 dimer interface [polypeptide binding]; other site 271848008313 ssDNA binding site [nucleotide binding]; other site 271848008314 tetramer (dimer of dimers) interface [polypeptide binding]; other site 271848008315 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 271848008316 putative hydrolase; Provisional; Region: PRK11460 271848008317 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 271848008318 Transposase, Mutator family; Region: Transposase_mut; pfam00872 271848008319 MULE transposase domain; Region: MULE; pfam10551 271848008320 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 271848008321 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 271848008322 Family description; Region: VCBS; pfam13517 271848008323 Family description; Region: VCBS; pfam13517 271848008324 Family description; Region: VCBS; pfam13517 271848008325 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 271848008326 Insecticide toxin TcdB middle/C-terminal region; Region: TcdB_toxin_midC; pfam12255 271848008327 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 271848008328 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 271848008329 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 271848008330 phosphopeptide binding site; other site 271848008331 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 271848008332 active site 271848008333 ATP binding site [chemical binding]; other site 271848008334 TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903 271848008335 substrate binding site [chemical binding]; other site 271848008336 activation loop (A-loop); other site 271848008337 cyclase homology domain; Region: CHD; cd07302 271848008338 dimer interface [polypeptide binding]; other site 271848008339 nucleotidyl binding site; other site 271848008340 metal binding site [ion binding]; metal-binding site 271848008341 AAA ATPase domain; Region: AAA_16; pfam13191 271848008342 ribosomal natural product, two-chain TOMM family; Region: RNP_Burkhold; TIGR03795 271848008343 ribosomal natural product, two-chain TOMM family; Region: RNP_Burkhold; TIGR03795 271848008344 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 271848008345 YcaO-like family; Region: YcaO; pfam02624 271848008346 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 271848008347 aldolase II superfamily protein; Provisional; Region: PRK07044 271848008348 intersubunit interface [polypeptide binding]; other site 271848008349 active site 271848008350 Zn2+ binding site [ion binding]; other site 271848008351 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 271848008352 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271848008353 metal binding site [ion binding]; metal-binding site 271848008354 active site 271848008355 I-site; other site 271848008356 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 271848008357 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 271848008358 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 271848008359 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 271848008360 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 271848008361 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 271848008362 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 271848008363 Substrate binding site; other site 271848008364 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 271848008365 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 271848008366 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 271848008367 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 271848008368 putative ADP-binding pocket [chemical binding]; other site 271848008369 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 271848008370 active site 271848008371 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 271848008372 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848008373 Walker A motif; other site 271848008374 ATP binding site [chemical binding]; other site 271848008375 Walker B motif; other site 271848008376 arginine finger; other site 271848008377 exosortase A system-associated hydrolase 1; Region: hydr1_PEP; TIGR03100 271848008378 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 271848008379 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 271848008380 Domain of unknown function (DUF1839); Region: DUF1839; pfam08893 271848008381 Gly_His_Pro_Ser_Thr_tRNA synthetase class II core domain. This domain is the core catalytic domain of tRNA synthetases of the subgroup containing glycyl, histidyl, prolyl, seryl and threonyl tRNA synthetases. It is primarily responsible for ATP-dependent...; Region: Gly_His_Pro_Ser_Thr_tRS_core; cd00670 271848008382 dimer interface [polypeptide binding]; other site 271848008383 motif 1; other site 271848008384 active site 271848008385 motif 2; other site 271848008386 motif 3; other site 271848008387 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 271848008388 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 271848008389 active site 271848008390 acyl carrier protein; Provisional; Region: PRK07081 271848008391 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 271848008392 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 271848008393 ligand binding site [chemical binding]; other site 271848008394 flexible hinge region; other site 271848008395 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 271848008396 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 271848008397 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 271848008398 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 271848008399 non-specific DNA interactions [nucleotide binding]; other site 271848008400 DNA binding site [nucleotide binding] 271848008401 sequence specific DNA binding site [nucleotide binding]; other site 271848008402 putative cAMP binding site [chemical binding]; other site 271848008403 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 271848008404 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 271848008405 Bacterial sugar transferase; Region: Bac_transf; pfam02397 271848008406 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 271848008407 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 271848008408 SLBB domain; Region: SLBB; pfam10531 271848008409 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 271848008410 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 271848008411 CHRD domain; Region: CHRD; pfam07452 271848008412 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 271848008413 EcsC protein family; Region: EcsC; pfam12787 271848008414 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848008415 Major Facilitator Superfamily; Region: MFS_1; pfam07690 271848008416 putative substrate translocation pore; other site 271848008417 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848008418 Transcriptional regulators [Transcription]; Region: MarR; COG1846 271848008419 MarR family; Region: MarR; pfam01047 271848008420 intracellular protease, PfpI family; Region: PfpI; TIGR01382 271848008421 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 271848008422 conserved cys residue [active] 271848008423 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 271848008424 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 271848008425 dimer interface [polypeptide binding]; other site 271848008426 active site 271848008427 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 271848008428 substrate binding site [chemical binding]; other site 271848008429 catalytic residue [active] 271848008430 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 271848008431 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 271848008432 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 271848008433 putative active site [active] 271848008434 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 271848008435 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 271848008436 active site 271848008437 putative substrate binding pocket [chemical binding]; other site 271848008438 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 271848008439 homotrimer interaction site [polypeptide binding]; other site 271848008440 putative active site [active] 271848008441 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 271848008442 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 271848008443 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 271848008444 threonine dehydratase; Reviewed; Region: PRK09224 271848008445 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 271848008446 tetramer interface [polypeptide binding]; other site 271848008447 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848008448 catalytic residue [active] 271848008449 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 271848008450 putative Ile/Val binding site [chemical binding]; other site 271848008451 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 271848008452 putative Ile/Val binding site [chemical binding]; other site 271848008453 Protein of unknown function (DUF3683); Region: DUF3683; pfam12447 271848008454 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 271848008455 FAD binding domain; Region: FAD_binding_4; pfam01565 271848008456 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 271848008457 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 271848008458 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 271848008459 Cysteine-rich domain; Region: CCG; pfam02754 271848008460 Domain of unknown function (DUF3400); Region: DUF3400; pfam11880 271848008461 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 271848008462 nucleotide binding site/active site [active] 271848008463 HIT family signature motif; other site 271848008464 catalytic residue [active] 271848008465 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 271848008466 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 271848008467 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848008468 S-adenosylmethionine binding site [chemical binding]; other site 271848008469 Tim44-like domain; Region: Tim44; pfam04280 271848008470 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 271848008471 SCP-2 sterol transfer family; Region: SCP2; pfam02036 271848008472 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 271848008473 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 271848008474 Thiopurine S-methyltransferase (TPMT); Region: TPMT; pfam05724 271848008475 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 271848008476 Uncharacterized conserved protein [Function unknown]; Region: COG2928 271848008477 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 271848008478 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 271848008479 dimer interface [polypeptide binding]; other site 271848008480 anticodon binding site; other site 271848008481 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 271848008482 homodimer interface [polypeptide binding]; other site 271848008483 motif 1; other site 271848008484 active site 271848008485 motif 2; other site 271848008486 GAD domain; Region: GAD; pfam02938 271848008487 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 271848008488 motif 3; other site 271848008489 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 271848008490 nudix motif; other site 271848008491 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 271848008492 PLD-like domain; Region: PLDc_2; pfam13091 271848008493 putative active site [active] 271848008494 catalytic site [active] 271848008495 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 271848008496 PLD-like domain; Region: PLDc_2; pfam13091 271848008497 putative active site [active] 271848008498 catalytic site [active] 271848008499 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 271848008500 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 271848008501 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 271848008502 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 271848008503 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 271848008504 FAD binding site [chemical binding]; other site 271848008505 substrate binding site [chemical binding]; other site 271848008506 catalytic residues [active] 271848008507 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 271848008508 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 271848008509 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 271848008510 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 271848008511 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 271848008512 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 271848008513 substrate binding site [chemical binding]; other site 271848008514 oxyanion hole (OAH) forming residues; other site 271848008515 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 271848008516 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 271848008517 dimer interface [polypeptide binding]; other site 271848008518 active site 271848008519 enoyl-CoA hydratase; Provisional; Region: PRK06688 271848008520 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 271848008521 substrate binding site [chemical binding]; other site 271848008522 oxyanion hole (OAH) forming residues; other site 271848008523 trimer interface [polypeptide binding]; other site 271848008524 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 271848008525 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 271848008526 conserved hypothetical protein; Region: nitr_red_assoc; TIGR02664 271848008527 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 271848008528 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 271848008529 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 271848008530 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 271848008531 Walker A/P-loop; other site 271848008532 ATP binding site [chemical binding]; other site 271848008533 Q-loop/lid; other site 271848008534 ABC transporter signature motif; other site 271848008535 Walker B; other site 271848008536 D-loop; other site 271848008537 H-loop/switch region; other site 271848008538 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 271848008539 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 271848008540 Substrate binding site; other site 271848008541 metal-binding site 271848008542 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 271848008543 Phosphotransferase enzyme family; Region: APH; pfam01636 271848008544 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 271848008545 Organic solvent tolerance protein; Region: OstA_C; pfam04453 271848008546 SurA N-terminal domain; Region: SurA_N; pfam09312 271848008547 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 271848008548 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 271848008549 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 271848008550 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK01909 271848008551 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 271848008552 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 271848008553 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 271848008554 EamA-like transporter family; Region: EamA; pfam00892 271848008555 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 271848008556 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 271848008557 dimer interface [polypeptide binding]; other site 271848008558 active site 271848008559 metal binding site [ion binding]; metal-binding site 271848008560 glutathione binding site [chemical binding]; other site 271848008561 Protein of unknown function DUF45; Region: DUF45; pfam01863 271848008562 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 271848008563 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 271848008564 putative acyl-acceptor binding pocket; other site 271848008565 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 271848008566 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 271848008567 active site 271848008568 motif I; other site 271848008569 motif II; other site 271848008570 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 271848008571 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 271848008572 dimer interface [polypeptide binding]; other site 271848008573 motif 1; other site 271848008574 active site 271848008575 motif 2; other site 271848008576 motif 3; other site 271848008577 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 271848008578 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 271848008579 putative active site [active] 271848008580 catalytic triad [active] 271848008581 putative dimer interface [polypeptide binding]; other site 271848008582 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 271848008583 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 271848008584 Transporter associated domain; Region: CorC_HlyC; smart01091 271848008585 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 271848008586 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 271848008587 putative active site pocket [active] 271848008588 dimerization interface [polypeptide binding]; other site 271848008589 putative catalytic residue [active] 271848008590 unkown domain/putative metalloprotease fusion protein; Provisional; Region: PRK13963 271848008591 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 271848008592 PhoH-like protein; Region: PhoH; pfam02562 271848008593 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 271848008594 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 271848008595 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 271848008596 FeS/SAM binding site; other site 271848008597 TRAM domain; Region: TRAM; pfam01938 271848008598 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848008599 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848008600 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 271848008601 putative effector binding pocket; other site 271848008602 dimerization interface [polypeptide binding]; other site 271848008603 MFS transport protein AraJ; Provisional; Region: PRK10091 271848008604 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848008605 putative substrate translocation pore; other site 271848008606 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 271848008607 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 271848008608 non-specific DNA binding site [nucleotide binding]; other site 271848008609 salt bridge; other site 271848008610 sequence-specific DNA binding site [nucleotide binding]; other site 271848008611 Cupin domain; Region: Cupin_2; pfam07883 271848008612 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 271848008613 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 271848008614 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 271848008615 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 271848008616 motif II; other site 271848008617 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 271848008618 amphipathic channel; other site 271848008619 Asn-Pro-Ala signature motifs; other site 271848008620 glycerol kinase; Provisional; Region: glpK; PRK00047 271848008621 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 271848008622 N- and C-terminal domain interface [polypeptide binding]; other site 271848008623 active site 271848008624 MgATP binding site [chemical binding]; other site 271848008625 catalytic site [active] 271848008626 metal binding site [ion binding]; metal-binding site 271848008627 glycerol binding site [chemical binding]; other site 271848008628 homotetramer interface [polypeptide binding]; other site 271848008629 homodimer interface [polypeptide binding]; other site 271848008630 FBP binding site [chemical binding]; other site 271848008631 protein IIAGlc interface [polypeptide binding]; other site 271848008632 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 271848008633 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 271848008634 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 271848008635 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 271848008636 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 271848008637 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 271848008638 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 271848008639 dinuclear metal binding motif [ion binding]; other site 271848008640 helicase 45; Provisional; Region: PTZ00424 271848008641 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 271848008642 ATP binding site [chemical binding]; other site 271848008643 Mg++ binding site [ion binding]; other site 271848008644 motif III; other site 271848008645 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 271848008646 nucleotide binding region [chemical binding]; other site 271848008647 ATP-binding site [chemical binding]; other site 271848008648 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 271848008649 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 271848008650 Cytochrome c; Region: Cytochrom_C; pfam00034 271848008651 Cytochrome c; Region: Cytochrom_C; cl11414 271848008652 Cytochrome c; Region: Cytochrom_C; cl11414 271848008653 Copper resistance protein D; Region: CopD; pfam05425 271848008654 galactonate dehydratase; Provisional; Region: PRK14017 271848008655 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 271848008656 putative active site pocket [active] 271848008657 putative metal binding site [ion binding]; other site 271848008658 Uncharacterized conserved protein [Function unknown]; Region: COG3791 271848008659 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 271848008660 active site 271848008661 metal binding site [ion binding]; metal-binding site 271848008662 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 271848008663 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 271848008664 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 271848008665 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848008666 ATP binding site [chemical binding]; other site 271848008667 Mg2+ binding site [ion binding]; other site 271848008668 G-X-G motif; other site 271848008669 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 271848008670 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848008671 active site 271848008672 phosphorylation site [posttranslational modification] 271848008673 intermolecular recognition site; other site 271848008674 dimerization interface [polypeptide binding]; other site 271848008675 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 271848008676 Zn2+ binding site [ion binding]; other site 271848008677 Mg2+ binding site [ion binding]; other site 271848008678 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 271848008679 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271848008680 PAS domain; Region: PAS_9; pfam13426 271848008681 putative active site [active] 271848008682 heme pocket [chemical binding]; other site 271848008683 HAMP domain; Region: HAMP; pfam00672 271848008684 dimerization interface [polypeptide binding]; other site 271848008685 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 271848008686 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 271848008687 dimer interface [polypeptide binding]; other site 271848008688 putative CheW interface [polypeptide binding]; other site 271848008689 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 271848008690 FAD binding domain; Region: FAD_binding_4; pfam01565 271848008691 Cholesterol oxidase, substrate-binding; Region: Chol_subst-bind; pfam09129 271848008692 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 271848008693 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 271848008694 active site residue [active] 271848008695 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 271848008696 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 271848008697 Walker A/P-loop; other site 271848008698 ATP binding site [chemical binding]; other site 271848008699 Q-loop/lid; other site 271848008700 ABC transporter signature motif; other site 271848008701 Walker B; other site 271848008702 D-loop; other site 271848008703 H-loop/switch region; other site 271848008704 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 271848008705 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 271848008706 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848008707 dimer interface [polypeptide binding]; other site 271848008708 conserved gate region; other site 271848008709 putative PBP binding loops; other site 271848008710 ABC-ATPase subunit interface; other site 271848008711 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848008712 dimer interface [polypeptide binding]; other site 271848008713 ABC-ATPase subunit interface; other site 271848008714 putative PBP binding loops; other site 271848008715 Erythromycin esterase; Region: Erythro_esteras; pfam05139 271848008716 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 271848008717 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 271848008718 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 271848008719 active site 271848008720 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 271848008721 active site 271848008722 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 271848008723 Transglycosylase; Region: Transgly; cl17702 271848008724 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 271848008725 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 271848008726 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 271848008727 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 271848008728 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 271848008729 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 271848008730 active site 271848008731 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848008732 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848008733 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 271848008734 putative effector binding pocket; other site 271848008735 putative dimerization interface [polypeptide binding]; other site 271848008736 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 271848008737 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271848008738 dimer interface [polypeptide binding]; other site 271848008739 phosphorylation site [posttranslational modification] 271848008740 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848008741 ATP binding site [chemical binding]; other site 271848008742 Mg2+ binding site [ion binding]; other site 271848008743 G-X-G motif; other site 271848008744 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848008745 Response regulator receiver domain; Region: Response_reg; pfam00072 271848008746 active site 271848008747 phosphorylation site [posttranslational modification] 271848008748 intermolecular recognition site; other site 271848008749 dimerization interface [polypeptide binding]; other site 271848008750 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 271848008751 BetR domain; Region: BetR; pfam08667 271848008752 Response regulator receiver domain; Region: Response_reg; pfam00072 271848008753 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848008754 active site 271848008755 phosphorylation site [posttranslational modification] 271848008756 intermolecular recognition site; other site 271848008757 dimerization interface [polypeptide binding]; other site 271848008758 S-100: S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100...; Region: S-100; cl08302 271848008759 Ca2+ binding site [ion binding]; other site 271848008760 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 271848008761 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 271848008762 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848008763 putative substrate translocation pore; other site 271848008764 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 271848008765 HAMP domain; Region: HAMP; pfam00672 271848008766 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271848008767 dimer interface [polypeptide binding]; other site 271848008768 phosphorylation site [posttranslational modification] 271848008769 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848008770 ATP binding site [chemical binding]; other site 271848008771 Mg2+ binding site [ion binding]; other site 271848008772 G-X-G motif; other site 271848008773 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 271848008774 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848008775 active site 271848008776 phosphorylation site [posttranslational modification] 271848008777 intermolecular recognition site; other site 271848008778 dimerization interface [polypeptide binding]; other site 271848008779 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 271848008780 DNA binding site [nucleotide binding] 271848008781 recombinase A; Provisional; Region: recA; PRK09354 271848008782 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 271848008783 hexamer interface [polypeptide binding]; other site 271848008784 Walker A motif; other site 271848008785 ATP binding site [chemical binding]; other site 271848008786 Walker B motif; other site 271848008787 recombination regulator RecX; Provisional; Region: recX; PRK14136 271848008788 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 271848008789 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 271848008790 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 271848008791 CoA-ligase; Region: Ligase_CoA; pfam00549 271848008792 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 271848008793 CoA binding domain; Region: CoA_binding; smart00881 271848008794 CoA-ligase; Region: Ligase_CoA; pfam00549 271848008795 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 271848008796 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 271848008797 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 271848008798 O-Antigen ligase; Region: Wzy_C; pfam04932 271848008799 Domain of unknown function (DUF3366); Region: DUF3366; pfam11846 271848008800 hypothetical protein; Provisional; Region: PRK11667 271848008801 Gram-negative bacterial tonB protein; Region: TonB; cl10048 271848008802 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 271848008803 trimer interface [polypeptide binding]; other site 271848008804 dimer interface [polypeptide binding]; other site 271848008805 putative active site [active] 271848008806 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 271848008807 Peptidase family M48; Region: Peptidase_M48; pfam01435 271848008808 Protein of unknown function (DUF2946); Region: DUF2944; pfam11161 271848008809 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 271848008810 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 271848008811 SnoaL-like domain; Region: SnoaL_3; pfam13474 271848008812 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 271848008813 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 271848008814 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 271848008815 putative active site [active] 271848008816 Zinc-finger domain; Region: zf-CHCC; cl01821 271848008817 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 271848008818 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 271848008819 homodimer interface [polypeptide binding]; other site 271848008820 substrate-cofactor binding pocket; other site 271848008821 catalytic residue [active] 271848008822 AzlC protein; Region: AzlC; cl00570 271848008823 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 271848008824 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 271848008825 Phosphoglycerate kinase; Region: PGK; pfam00162 271848008826 substrate binding site [chemical binding]; other site 271848008827 hinge regions; other site 271848008828 ADP binding site [chemical binding]; other site 271848008829 catalytic site [active] 271848008830 pyruvate kinase; Provisional; Region: PRK05826 271848008831 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 271848008832 domain interfaces; other site 271848008833 active site 271848008834 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 271848008835 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 271848008836 intersubunit interface [polypeptide binding]; other site 271848008837 active site 271848008838 zinc binding site [ion binding]; other site 271848008839 Na+ binding site [ion binding]; other site 271848008840 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 271848008841 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 271848008842 ATP binding site [chemical binding]; other site 271848008843 active site 271848008844 substrate binding site [chemical binding]; other site 271848008845 AIR carboxylase; Region: AIRC; cl00310 271848008846 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 271848008847 ATP-grasp domain; Region: ATP-grasp; pfam02222 271848008848 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 271848008849 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 271848008850 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 271848008851 active site 271848008852 catalytic triad [active] 271848008853 oxyanion hole [active] 271848008854 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 271848008855 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 271848008856 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 271848008857 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 271848008858 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848008859 active site 271848008860 phosphorylation site [posttranslational modification] 271848008861 intermolecular recognition site; other site 271848008862 dimerization interface [polypeptide binding]; other site 271848008863 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 271848008864 DNA binding site [nucleotide binding] 271848008865 sensor protein QseC; Provisional; Region: PRK10337 271848008866 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848008867 ATP binding site [chemical binding]; other site 271848008868 Mg2+ binding site [ion binding]; other site 271848008869 G-X-G motif; other site 271848008870 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 271848008871 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 271848008872 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 271848008873 protein binding site [polypeptide binding]; other site 271848008874 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 271848008875 protein binding site [polypeptide binding]; other site 271848008876 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 271848008877 Domain of unknown function (DUF427); Region: DUF427; pfam04248 271848008878 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 271848008879 hydrophobic ligand binding site; other site 271848008880 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 271848008881 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 271848008882 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 271848008883 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 271848008884 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 271848008885 HlyD family secretion protein; Region: HlyD_3; pfam13437 271848008886 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 271848008887 Protein export membrane protein; Region: SecD_SecF; cl14618 271848008888 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 271848008889 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 271848008890 xanthine permease; Region: pbuX; TIGR03173 271848008891 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 271848008892 nucleotide binding site [chemical binding]; other site 271848008893 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 271848008894 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 271848008895 conserved cys residue [active] 271848008896 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848008897 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848008898 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 271848008899 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 271848008900 substrate binding site [chemical binding]; other site 271848008901 catalytic Zn binding site [ion binding]; other site 271848008902 NAD binding site [chemical binding]; other site 271848008903 structural Zn binding site [ion binding]; other site 271848008904 dimer interface [polypeptide binding]; other site 271848008905 S-formylglutathione hydrolase; Region: PLN02442 271848008906 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 271848008907 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 271848008908 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 271848008909 dimer interface [polypeptide binding]; other site 271848008910 putative PBP binding regions; other site 271848008911 ABC-ATPase subunit interface; other site 271848008912 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 271848008913 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 271848008914 Walker A/P-loop; other site 271848008915 ATP binding site [chemical binding]; other site 271848008916 Q-loop/lid; other site 271848008917 ABC transporter signature motif; other site 271848008918 Walker B; other site 271848008919 D-loop; other site 271848008920 H-loop/switch region; other site 271848008921 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 271848008922 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 271848008923 intersubunit interface [polypeptide binding]; other site 271848008924 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 271848008925 metal binding site 2 [ion binding]; metal-binding site 271848008926 putative DNA binding helix; other site 271848008927 metal binding site 1 [ion binding]; metal-binding site 271848008928 dimer interface [polypeptide binding]; other site 271848008929 structural Zn2+ binding site [ion binding]; other site 271848008930 sorbitol dehydrogenase; Provisional; Region: PRK07067 271848008931 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848008932 NAD(P) binding site [chemical binding]; other site 271848008933 active site 271848008934 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 271848008935 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 271848008936 substrate binding site [chemical binding]; other site 271848008937 ATP binding site [chemical binding]; other site 271848008938 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; pfam08013 271848008939 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 271848008940 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 271848008941 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 271848008942 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848008943 dimer interface [polypeptide binding]; other site 271848008944 conserved gate region; other site 271848008945 putative PBP binding loops; other site 271848008946 ABC-ATPase subunit interface; other site 271848008947 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 271848008948 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848008949 dimer interface [polypeptide binding]; other site 271848008950 conserved gate region; other site 271848008951 putative PBP binding loops; other site 271848008952 ABC-ATPase subunit interface; other site 271848008953 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 271848008954 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 271848008955 active site 271848008956 motif I; other site 271848008957 motif II; other site 271848008958 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 271848008959 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 271848008960 Walker A/P-loop; other site 271848008961 ATP binding site [chemical binding]; other site 271848008962 Q-loop/lid; other site 271848008963 ABC transporter signature motif; other site 271848008964 Walker B; other site 271848008965 D-loop; other site 271848008966 H-loop/switch region; other site 271848008967 TOBE domain; Region: TOBE; cl01440 271848008968 TOBE domain; Region: TOBE_2; pfam08402 271848008969 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 271848008970 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 271848008971 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 271848008972 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 271848008973 N- and C-terminal domain interface [polypeptide binding]; other site 271848008974 D-xylulose kinase; Region: XylB; TIGR01312 271848008975 active site 271848008976 MgATP binding site [chemical binding]; other site 271848008977 catalytic site [active] 271848008978 metal binding site [ion binding]; metal-binding site 271848008979 xylulose binding site [chemical binding]; other site 271848008980 homodimer interface [polypeptide binding]; other site 271848008981 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 271848008982 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 271848008983 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 271848008984 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848008985 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848008986 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848008987 dimerization interface [polypeptide binding]; other site 271848008988 benzoylformate decarboxylase; Reviewed; Region: PRK07092 271848008989 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 271848008990 PYR/PP interface [polypeptide binding]; other site 271848008991 dimer interface [polypeptide binding]; other site 271848008992 TPP binding site [chemical binding]; other site 271848008993 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 271848008994 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 271848008995 TPP-binding site [chemical binding]; other site 271848008996 dimer interface [polypeptide binding]; other site 271848008997 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 271848008998 Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105 271848008999 NAD(P) binding site [chemical binding]; other site 271848009000 catalytic residues [active] 271848009001 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 271848009002 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 271848009003 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 271848009004 benzoate transport; Region: 2A0115; TIGR00895 271848009005 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848009006 putative substrate translocation pore; other site 271848009007 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848009008 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 271848009009 Kynureninase [Amino acid transport and metabolism]; Region: COG3844 271848009010 kynureninase; Region: kynureninase; TIGR01814 271848009011 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 271848009012 catalytic residue [active] 271848009013 arylformamidase; Region: trp_arylform; TIGR03035 271848009014 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 271848009015 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 271848009016 putative DNA binding site [nucleotide binding]; other site 271848009017 putative Zn2+ binding site [ion binding]; other site 271848009018 AsnC family; Region: AsnC_trans_reg; pfam01037 271848009019 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 271848009020 methionine sulfoxide reductase A; Provisional; Region: PRK14054 271848009021 Protein of unknown function DUF72; Region: DUF72; pfam01904 271848009022 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 271848009023 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848009024 S-adenosylmethionine binding site [chemical binding]; other site 271848009025 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 271848009026 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 271848009027 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 271848009028 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 271848009029 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 271848009030 putative ATP binding site [chemical binding]; other site 271848009031 putative substrate interface [chemical binding]; other site 271848009032 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 271848009033 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 271848009034 catalytic residues [active] 271848009035 Pirin-related protein [General function prediction only]; Region: COG1741 271848009036 Pirin; Region: Pirin; pfam02678 271848009037 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 271848009038 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 271848009039 EamA-like transporter family; Region: EamA; pfam00892 271848009040 AMIN domain; Region: AMIN; pfam11741 271848009041 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 271848009042 active site 271848009043 metal binding site [ion binding]; metal-binding site 271848009044 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 271848009045 epoxyqueuosine reductase; Region: TIGR00276 271848009046 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 271848009047 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 271848009048 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 271848009049 DNA binding site [nucleotide binding] 271848009050 active site 271848009051 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 271848009052 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 271848009053 active site 271848009054 Int/Topo IB signature motif; other site 271848009055 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 271848009056 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 271848009057 acyl-activating enzyme (AAE) consensus motif; other site 271848009058 AMP binding site [chemical binding]; other site 271848009059 active site 271848009060 CoA binding site [chemical binding]; other site 271848009061 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 271848009062 putative deacylase active site [active] 271848009063 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 271848009064 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 271848009065 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 271848009066 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 271848009067 FAD binding domain; Region: FAD_binding_4; pfam01565 271848009068 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 271848009069 ornithine carbamoyltransferase; Provisional; Region: PRK00779 271848009070 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 271848009071 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 271848009072 Protein of unknown function (DUF3579); Region: DUF3579; pfam12112 271848009073 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 271848009074 Transposase; Region: DDE_Tnp_ISL3; pfam01610 271848009075 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 271848009076 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 271848009077 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 271848009078 Uncharacterized conserved protein [Function unknown]; Region: COG2912 271848009079 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 271848009080 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 271848009081 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848009082 NAD(P) binding site [chemical binding]; other site 271848009083 active site 271848009084 adenylate kinase; Reviewed; Region: adk; PRK00279 271848009085 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 271848009086 AMP-binding site [chemical binding]; other site 271848009087 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 271848009088 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 271848009089 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 271848009090 Ligand binding site; other site 271848009091 oligomer interface; other site 271848009092 Uncharacterized conserved protein [Function unknown]; Region: COG2835 271848009093 tetraacyldisaccharide 4'-kinase; Provisional; Region: PRK01906 271848009094 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 271848009095 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 271848009096 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 271848009097 generic binding surface II; other site 271848009098 generic binding surface I; other site 271848009099 superoxide dismutase; Provisional; Region: PRK10543 271848009100 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 271848009101 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 271848009102 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 271848009103 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 271848009104 Chromate transporter; Region: Chromate_transp; pfam02417 271848009105 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 271848009106 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 271848009107 ligand binding site [chemical binding]; other site 271848009108 flexible hinge region; other site 271848009109 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 271848009110 putative switch regulator; other site 271848009111 non-specific DNA interactions [nucleotide binding]; other site 271848009112 DNA binding site [nucleotide binding] 271848009113 sequence specific DNA binding site [nucleotide binding]; other site 271848009114 putative cAMP binding site [chemical binding]; other site 271848009115 Protein of unknown function (DUF962); Region: DUF962; cl01879 271848009116 2-dehydropantoate 2-reductase; Provisional; Region: PRK08229 271848009117 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 271848009118 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 271848009119 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848009120 S-adenosylmethionine binding site [chemical binding]; other site 271848009121 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 271848009122 putative transporter; Provisional; Region: PRK10504 271848009123 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848009124 putative substrate translocation pore; other site 271848009125 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848009126 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 271848009127 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 271848009128 DNA binding residues [nucleotide binding] 271848009129 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 271848009130 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 271848009131 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 271848009132 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 271848009133 DNA-binding site [nucleotide binding]; DNA binding site 271848009134 UTRA domain; Region: UTRA; pfam07702 271848009135 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 271848009136 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 271848009137 active site 271848009138 catalytic tetrad [active] 271848009139 elongation factor G; Reviewed; Region: PRK00007 271848009140 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 271848009141 G1 box; other site 271848009142 putative GEF interaction site [polypeptide binding]; other site 271848009143 GTP/Mg2+ binding site [chemical binding]; other site 271848009144 Switch I region; other site 271848009145 G2 box; other site 271848009146 G3 box; other site 271848009147 Switch II region; other site 271848009148 G4 box; other site 271848009149 G5 box; other site 271848009150 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 271848009151 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 271848009152 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 271848009153 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 271848009154 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 271848009155 pseudouridine synthase; Region: TIGR00093 271848009156 active site 271848009157 isocitrate dehydrogenase; Validated; Region: PRK07362 271848009158 isocitrate dehydrogenase; Reviewed; Region: PRK07006 271848009159 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 271848009160 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 271848009161 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 271848009162 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 271848009163 DNA-binding site [nucleotide binding]; DNA binding site 271848009164 RNA-binding motif; other site 271848009165 Uncharacterized conserved protein [Function unknown]; Region: COG2127 271848009166 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 271848009167 Clp amino terminal domain; Region: Clp_N; pfam02861 271848009168 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848009169 Walker A motif; other site 271848009170 ATP binding site [chemical binding]; other site 271848009171 Walker B motif; other site 271848009172 arginine finger; other site 271848009173 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848009174 Walker A motif; other site 271848009175 ATP binding site [chemical binding]; other site 271848009176 Walker B motif; other site 271848009177 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 271848009178 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 271848009179 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 271848009180 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 271848009181 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 271848009182 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 271848009183 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 271848009184 trimer interface [polypeptide binding]; other site 271848009185 active site 271848009186 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 271848009187 Flavoprotein; Region: Flavoprotein; pfam02441 271848009188 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 271848009189 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 271848009190 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 271848009191 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 271848009192 active site 271848009193 HIGH motif; other site 271848009194 nucleotide binding site [chemical binding]; other site 271848009195 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 271848009196 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 271848009197 active site 271848009198 KMSKS motif; other site 271848009199 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 271848009200 tRNA binding surface [nucleotide binding]; other site 271848009201 anticodon binding site; other site 271848009202 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 271848009203 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 271848009204 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 271848009205 active site 271848009206 Riboflavin kinase; Region: Flavokinase; smart00904 271848009207 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 271848009208 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 271848009209 active site 271848009210 substrate binding site [chemical binding]; other site 271848009211 cosubstrate binding site; other site 271848009212 catalytic site [active] 271848009213 16S rRNA methyltransferase B; Provisional; Region: PRK14901 271848009214 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848009215 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 271848009216 Mechanosensitive ion channel; Region: MS_channel; pfam00924 271848009217 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 271848009218 Fatty acid desaturase; Region: FA_desaturase; pfam00487 271848009219 Di-iron ligands [ion binding]; other site 271848009220 Transposase; Region: DDE_Tnp_ISL3; pfam01610 271848009221 quinolinate synthetase; Provisional; Region: PRK09375 271848009222 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06978 271848009223 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 271848009224 dimerization interface [polypeptide binding]; other site 271848009225 active site 271848009226 L-aspartate oxidase; Provisional; Region: PRK09077 271848009227 L-aspartate oxidase; Provisional; Region: PRK06175 271848009228 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 271848009229 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 271848009230 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 271848009231 hypothetical protein; Reviewed; Region: PRK00024 271848009232 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 271848009233 MPN+ (JAMM) motif; other site 271848009234 Zinc-binding site [ion binding]; other site 271848009235 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 271848009236 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 271848009237 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 271848009238 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 271848009239 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 271848009240 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 271848009241 TM-ABC transporter signature motif; other site 271848009242 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 271848009243 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 271848009244 TM-ABC transporter signature motif; other site 271848009245 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 271848009246 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 271848009247 Walker A/P-loop; other site 271848009248 ATP binding site [chemical binding]; other site 271848009249 Q-loop/lid; other site 271848009250 ABC transporter signature motif; other site 271848009251 Walker B; other site 271848009252 D-loop; other site 271848009253 H-loop/switch region; other site 271848009254 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 271848009255 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 271848009256 Walker A/P-loop; other site 271848009257 ATP binding site [chemical binding]; other site 271848009258 Q-loop/lid; other site 271848009259 ABC transporter signature motif; other site 271848009260 Walker B; other site 271848009261 D-loop; other site 271848009262 H-loop/switch region; other site 271848009263 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 271848009264 putative acetyltransferase; Provisional; Region: PRK03624 271848009265 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 271848009266 Coenzyme A binding pocket [chemical binding]; other site 271848009267 acetylornithine transaminase protein; Provisional; Region: argD; PRK03715 271848009268 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 271848009269 inhibitor-cofactor binding pocket; inhibition site 271848009270 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848009271 catalytic residue [active] 271848009272 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 271848009273 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 271848009274 catalytic loop [active] 271848009275 iron binding site [ion binding]; other site 271848009276 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 271848009277 FAD binding pocket [chemical binding]; other site 271848009278 FAD binding motif [chemical binding]; other site 271848009279 phosphate binding motif [ion binding]; other site 271848009280 beta-alpha-beta structure motif; other site 271848009281 NAD binding pocket [chemical binding]; other site 271848009282 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 271848009283 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 271848009284 putative NAD(P) binding site [chemical binding]; other site 271848009285 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 271848009286 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 271848009287 RNA binding surface [nucleotide binding]; other site 271848009288 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 271848009289 active site 271848009290 uracil binding [chemical binding]; other site 271848009291 CopC domain; Region: CopC; pfam04234 271848009292 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848009293 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848009294 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848009295 dimerization interface [polypeptide binding]; other site 271848009296 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848009297 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848009298 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848009299 dimerization interface [polypeptide binding]; other site 271848009300 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 271848009301 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 271848009302 MOSC domain; Region: MOSC; pfam03473 271848009303 3-alpha domain; Region: 3-alpha; pfam03475 271848009304 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 271848009305 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 271848009306 inhibitor site; inhibition site 271848009307 active site 271848009308 dimer interface [polypeptide binding]; other site 271848009309 catalytic residue [active] 271848009310 class II aldolase/adducin domain protein; Provisional; Region: PRK07090 271848009311 intersubunit interface [polypeptide binding]; other site 271848009312 active site 271848009313 Zn2+ binding site [ion binding]; other site 271848009314 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 271848009315 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 271848009316 non-specific DNA binding site [nucleotide binding]; other site 271848009317 salt bridge; other site 271848009318 sequence-specific DNA binding site [nucleotide binding]; other site 271848009319 Cupin domain; Region: Cupin_2; pfam07883 271848009320 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 271848009321 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 271848009322 dimerization interface [polypeptide binding]; other site 271848009323 substrate binding pocket [chemical binding]; other site 271848009324 DctM-like transporters; Region: DctM; pfam06808 271848009325 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 271848009326 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 271848009327 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 271848009328 Transcriptional regulators [Transcription]; Region: PurR; COG1609 271848009329 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 271848009330 DNA binding site [nucleotide binding] 271848009331 domain linker motif; other site 271848009332 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 271848009333 dimerization interface [polypeptide binding]; other site 271848009334 ligand binding site [chemical binding]; other site 271848009335 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12684 271848009336 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848009337 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 271848009338 substrate binding site [chemical binding]; other site 271848009339 dimerization interface [polypeptide binding]; other site 271848009340 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 271848009341 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 271848009342 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 271848009343 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 271848009344 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 271848009345 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 271848009346 Active Sites [active] 271848009347 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 271848009348 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 271848009349 Active Sites [active] 271848009350 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 271848009351 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 271848009352 CysD dimerization site [polypeptide binding]; other site 271848009353 G1 box; other site 271848009354 putative GEF interaction site [polypeptide binding]; other site 271848009355 GTP/Mg2+ binding site [chemical binding]; other site 271848009356 Switch I region; other site 271848009357 G2 box; other site 271848009358 G3 box; other site 271848009359 Switch II region; other site 271848009360 G4 box; other site 271848009361 G5 box; other site 271848009362 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 271848009363 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 271848009364 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 271848009365 active site 271848009366 SAM binding site [chemical binding]; other site 271848009367 homodimer interface [polypeptide binding]; other site 271848009368 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 271848009369 putative active site [active] 271848009370 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 271848009371 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 271848009372 Predicted permeases [General function prediction only]; Region: COG0795 271848009373 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 271848009374 multifunctional aminopeptidase A; Provisional; Region: PRK00913 271848009375 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 271848009376 interface (dimer of trimers) [polypeptide binding]; other site 271848009377 Substrate-binding/catalytic site; other site 271848009378 Zn-binding sites [ion binding]; other site 271848009379 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364 271848009380 Protein of unknown function (DUF2486); Region: DUF2486; pfam10667 271848009381 Cytochrome c; Region: Cytochrom_C; cl11414 271848009382 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 271848009383 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 271848009384 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848009385 The C-terminal substrate binding domain of LysR-type transcriptional regulator, IlvR, involved in the biosynthesis of isoleucine, leucine and valine; contains type 2 periplasmic binding fold; Region: PBP2_IlvR; cd08453 271848009386 putative dimerization interface [polypeptide binding]; other site 271848009387 putative substrate binding pocket [chemical binding]; other site 271848009388 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 271848009389 Protein of unknown function (DUF541); Region: SIMPL; cl01077 271848009390 Uncharacterized conserved protein [Function unknown]; Region: COG2947 271848009391 Cell division protein ZapA; Region: ZapA; cl01146 271848009392 UV radiation resistance protein and autophagy-related subunit 14; Region: Atg14; pfam10186 271848009393 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 271848009394 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 271848009395 N-terminal plug; other site 271848009396 ligand-binding site [chemical binding]; other site 271848009397 FecCD transport family; Region: FecCD; pfam01032 271848009398 dimer interface [polypeptide binding]; other site 271848009399 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 271848009400 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 271848009401 Walker A/P-loop; other site 271848009402 ATP binding site [chemical binding]; other site 271848009403 Q-loop/lid; other site 271848009404 ABC transporter signature motif; other site 271848009405 Walker B; other site 271848009406 D-loop; other site 271848009407 H-loop/switch region; other site 271848009408 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 271848009409 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 271848009410 putative dimer interface [polypeptide binding]; other site 271848009411 active site pocket [active] 271848009412 putative cataytic base [active] 271848009413 cobalamin synthase; Reviewed; Region: cobS; PRK00235 271848009414 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 271848009415 catalytic core [active] 271848009416 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 271848009417 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 271848009418 cobalamin binding residues [chemical binding]; other site 271848009419 putative BtuC binding residues; other site 271848009420 dimer interface [polypeptide binding]; other site 271848009421 putative threonine-phosphate decarboxylase; Provisional; Region: PRK06959 271848009422 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 271848009423 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 271848009424 catalytic residue [active] 271848009425 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 271848009426 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 271848009427 homotrimer interface [polypeptide binding]; other site 271848009428 Walker A motif; other site 271848009429 GTP binding site [chemical binding]; other site 271848009430 Walker B motif; other site 271848009431 cobyric acid synthase; Provisional; Region: PRK00784 271848009432 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 271848009433 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 271848009434 catalytic triad [active] 271848009435 DoxX; Region: DoxX; pfam07681 271848009436 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 271848009437 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 271848009438 P-loop; other site 271848009439 Magnesium ion binding site [ion binding]; other site 271848009440 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 271848009441 tetramerization interface [polypeptide binding]; other site 271848009442 active site 271848009443 pantoate--beta-alanine ligase; Region: panC; TIGR00018 271848009444 Pantoate-beta-alanine ligase; Region: PanC; cd00560 271848009445 active site 271848009446 ATP-binding site [chemical binding]; other site 271848009447 pantoate-binding site; other site 271848009448 HXXH motif; other site 271848009449 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 271848009450 Protein of unknown function (DUF3460); Region: DUF3460; pfam11943 271848009451 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 271848009452 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 271848009453 Surface antigen; Region: Bac_surface_Ag; pfam01103 271848009454 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 271848009455 Family of unknown function (DUF490); Region: DUF490; pfam04357 271848009456 O-methyltransferase; Region: Methyltransf_2; pfam00891 271848009457 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 271848009458 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 271848009459 active site 271848009460 HIGH motif; other site 271848009461 KMSKS motif; other site 271848009462 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 271848009463 tRNA binding surface [nucleotide binding]; other site 271848009464 anticodon binding site; other site 271848009465 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 271848009466 dimer interface [polypeptide binding]; other site 271848009467 putative tRNA-binding site [nucleotide binding]; other site 271848009468 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 271848009469 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 271848009470 ligand binding site [chemical binding]; other site 271848009471 Domain of unknown function DUF59; Region: DUF59; pfam01883 271848009472 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 271848009473 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 271848009474 Copper/zinc superoxide dismutase (SODC); Region: Sod_Cu; pfam00080 271848009475 E-class dimer interface [polypeptide binding]; other site 271848009476 P-class dimer interface [polypeptide binding]; other site 271848009477 active site 271848009478 Cu2+ binding site [ion binding]; other site 271848009479 Zn2+ binding site [ion binding]; other site 271848009480 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 271848009481 trimer interface [polypeptide binding]; other site 271848009482 active site 271848009483 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 271848009484 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 271848009485 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 271848009486 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 271848009487 catalytic residue [active] 271848009488 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 271848009489 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 271848009490 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 271848009491 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 271848009492 motif II; other site 271848009493 argininosuccinate lyase; Provisional; Region: PRK00855 271848009494 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 271848009495 active sites [active] 271848009496 tetramer interface [polypeptide binding]; other site 271848009497 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 271848009498 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 271848009499 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 271848009500 PapC C-terminal domain; Region: PapC_C; pfam13953 271848009501 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 271848009502 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 271848009503 Uncharacterized secreted protein [Function unknown]; Region: COG5430 271848009504 Spore Coat Protein U domain; Region: SCPU; pfam05229 271848009505 Uncharacterized secreted protein [Function unknown]; Region: COG5430 271848009506 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 271848009507 sequence-specific DNA binding site [nucleotide binding]; other site 271848009508 salt bridge; other site 271848009509 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848009510 S-adenosylmethionine binding site [chemical binding]; other site 271848009511 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 271848009512 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 271848009513 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 271848009514 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 271848009515 domain interfaces; other site 271848009516 active site 271848009517 bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase; Reviewed; Region: PRK06975 271848009518 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 271848009519 active site 271848009520 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 271848009521 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 271848009522 HemY protein N-terminus; Region: HemY_N; pfam07219 271848009523 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 271848009524 TPR motif; other site 271848009525 binding surface 271848009526 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 271848009527 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848009528 putative substrate translocation pore; other site 271848009529 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 3, classical (c) SDR; Region: BKR_3_SDR_c; cd05345 271848009530 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 271848009531 putative NAD(P) binding site [chemical binding]; other site 271848009532 active site 271848009533 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 271848009534 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 271848009535 NAD(P) binding site [chemical binding]; other site 271848009536 catalytic residues [active] 271848009537 catalytic residues [active] 271848009538 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 271848009539 dimer interface [polypeptide binding]; other site 271848009540 substrate binding site [chemical binding]; other site 271848009541 metal binding sites [ion binding]; metal-binding site 271848009542 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 271848009543 GIY-YIG motif/motif A; other site 271848009544 putative active site [active] 271848009545 putative metal binding site [ion binding]; other site 271848009546 putative transporter; Provisional; Region: PRK10504 271848009547 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848009548 putative substrate translocation pore; other site 271848009549 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848009550 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 271848009551 Protein of unknown function, DUF482; Region: DUF482; pfam04339 271848009552 NAD synthetase; Provisional; Region: PRK13981 271848009553 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 271848009554 multimer interface [polypeptide binding]; other site 271848009555 active site 271848009556 catalytic triad [active] 271848009557 protein interface 1 [polypeptide binding]; other site 271848009558 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 271848009559 homodimer interface [polypeptide binding]; other site 271848009560 NAD binding pocket [chemical binding]; other site 271848009561 ATP binding pocket [chemical binding]; other site 271848009562 Mg binding site [ion binding]; other site 271848009563 active-site loop [active] 271848009564 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 271848009565 Nitrogen regulatory protein P-II; Region: P-II; smart00938 271848009566 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 271848009567 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 271848009568 trimer interface [polypeptide binding]; other site 271848009569 eyelet of channel; other site 271848009570 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848009571 The C-terminal substrate biniding domain of an uncharacterized LysR-like transcriptional regulator Pa0477 related to DntR, contains the type 2 periplasmic binding fold; Region: PBP2_Pa0477; cd08468 271848009572 putative substrate binding pocket [chemical binding]; other site 271848009573 dimerization interface [polypeptide binding]; other site 271848009574 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 271848009575 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 271848009576 Coenzyme A binding pocket [chemical binding]; other site 271848009577 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 271848009578 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 271848009579 Walker A/P-loop; other site 271848009580 ATP binding site [chemical binding]; other site 271848009581 Q-loop/lid; other site 271848009582 ABC transporter signature motif; other site 271848009583 Walker B; other site 271848009584 D-loop; other site 271848009585 H-loop/switch region; other site 271848009586 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 271848009587 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848009588 dimer interface [polypeptide binding]; other site 271848009589 conserved gate region; other site 271848009590 putative PBP binding loops; other site 271848009591 ABC-ATPase subunit interface; other site 271848009592 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 271848009593 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848009594 dimer interface [polypeptide binding]; other site 271848009595 conserved gate region; other site 271848009596 putative PBP binding loops; other site 271848009597 ABC-ATPase subunit interface; other site 271848009598 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 271848009599 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 271848009600 substrate binding pocket [chemical binding]; other site 271848009601 membrane-bound complex binding site; other site 271848009602 hinge residues; other site 271848009603 Pirin-related protein [General function prediction only]; Region: COG1741 271848009604 Pirin; Region: Pirin; pfam02678 271848009605 osmolarity response regulator; Provisional; Region: ompR; PRK09468 271848009606 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848009607 active site 271848009608 phosphorylation site [posttranslational modification] 271848009609 intermolecular recognition site; other site 271848009610 dimerization interface [polypeptide binding]; other site 271848009611 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 271848009612 DNA binding site [nucleotide binding] 271848009613 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 271848009614 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271848009615 dimer interface [polypeptide binding]; other site 271848009616 phosphorylation site [posttranslational modification] 271848009617 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848009618 ATP binding site [chemical binding]; other site 271848009619 Mg2+ binding site [ion binding]; other site 271848009620 G-X-G motif; other site 271848009621 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 271848009622 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 271848009623 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848009624 dimer interface [polypeptide binding]; other site 271848009625 conserved gate region; other site 271848009626 putative PBP binding loops; other site 271848009627 ABC-ATPase subunit interface; other site 271848009628 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848009629 dimer interface [polypeptide binding]; other site 271848009630 conserved gate region; other site 271848009631 putative PBP binding loops; other site 271848009632 ABC-ATPase subunit interface; other site 271848009633 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 271848009634 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 271848009635 Walker A/P-loop; other site 271848009636 ATP binding site [chemical binding]; other site 271848009637 Q-loop/lid; other site 271848009638 ABC transporter signature motif; other site 271848009639 Walker B; other site 271848009640 D-loop; other site 271848009641 H-loop/switch region; other site 271848009642 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 271848009643 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 271848009644 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 271848009645 active site 271848009646 homotetramer interface [polypeptide binding]; other site 271848009647 Predicted ATPase [General function prediction only]; Region: COG3911 271848009648 AAA domain; Region: AAA_28; pfam13521 271848009649 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848009650 Major Facilitator Superfamily; Region: MFS_1; pfam07690 271848009651 putative substrate translocation pore; other site 271848009652 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848009653 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 271848009654 substrate binding site [chemical binding]; other site 271848009655 ecotin; Provisional; Region: PRK03719 271848009656 secondary substrate binding site; other site 271848009657 primary substrate binding site; other site 271848009658 inhibition loop; other site 271848009659 dimerization interface [polypeptide binding]; other site 271848009660 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 271848009661 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 271848009662 Transposase, Mutator family; Region: Transposase_mut; pfam00872 271848009663 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 271848009664 Walker A motif; other site 271848009665 ATP binding site [chemical binding]; other site 271848009666 AAA domain; Region: AAA_25; pfam13481 271848009667 Walker B motif; other site 271848009668 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 271848009669 Transposase; Region: DDE_Tnp_ISL3; pfam01610 271848009670 hypothetical protein; Region: PHA00662 271848009671 hypothetical protein; Region: PHA00661 271848009672 hypothetical protein; Region: PHA00661 271848009673 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 271848009674 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 271848009675 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 271848009676 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 271848009677 catalytic residue [active] 271848009678 Transposase, Mutator family; Region: Transposase_mut; pfam00872 271848009679 MULE transposase domain; Region: MULE; pfam10551 271848009680 integrase; Provisional; Region: PRK09692 271848009681 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 271848009682 active site 271848009683 Int/Topo IB signature motif; other site 271848009684 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423 271848009685 putative active site [active] 271848009686 SlyX; Region: SlyX; cl01090 271848009687 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 271848009688 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848009689 Walker A motif; other site 271848009690 ATP binding site [chemical binding]; other site 271848009691 Walker B motif; other site 271848009692 arginine finger; other site 271848009693 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 271848009694 Rubredoxin [Energy production and conversion]; Region: COG1773 271848009695 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 271848009696 iron binding site [ion binding]; other site 271848009697 Domain of unknown function (DUF4399); Region: DUF4399; pfam14347 271848009698 ABC transporter ATPase component; Reviewed; Region: PRK11147 271848009699 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 271848009700 Walker A/P-loop; other site 271848009701 ATP binding site [chemical binding]; other site 271848009702 Q-loop/lid; other site 271848009703 ABC transporter signature motif; other site 271848009704 Walker B; other site 271848009705 D-loop; other site 271848009706 H-loop/switch region; other site 271848009707 ABC transporter; Region: ABC_tran_2; pfam12848 271848009708 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 271848009709 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 271848009710 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848009711 ATP binding site [chemical binding]; other site 271848009712 Mg2+ binding site [ion binding]; other site 271848009713 G-X-G motif; other site 271848009714 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 271848009715 anchoring element; other site 271848009716 dimer interface [polypeptide binding]; other site 271848009717 ATP binding site [chemical binding]; other site 271848009718 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 271848009719 active site 271848009720 metal binding site [ion binding]; metal-binding site 271848009721 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 271848009722 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 271848009723 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 271848009724 CAP-like domain; other site 271848009725 active site 271848009726 primary dimer interface [polypeptide binding]; other site 271848009727 Predicted integral membrane protein [Function unknown]; Region: COG5615 271848009728 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848009729 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848009730 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 271848009731 dimerization interface [polypeptide binding]; other site 271848009732 Predicted membrane protein [Function unknown]; Region: COG4125 271848009733 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 271848009734 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 271848009735 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 271848009736 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 271848009737 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 271848009738 active site 271848009739 Zn binding site [ion binding]; other site 271848009740 Chromate transporter; Region: Chromate_transp; pfam02417 271848009741 Chromate transporter; Region: Chromate_transp; pfam02417 271848009742 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 271848009743 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271848009744 metal binding site [ion binding]; metal-binding site 271848009745 active site 271848009746 I-site; other site 271848009747 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 271848009748 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 271848009749 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 271848009750 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 271848009751 homotrimer interaction site [polypeptide binding]; other site 271848009752 putative active site [active] 271848009753 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 271848009754 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 271848009755 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848009756 homodimer interface [polypeptide binding]; other site 271848009757 catalytic residue [active] 271848009758 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 271848009759 EamA-like transporter family; Region: EamA; pfam00892 271848009760 EamA-like transporter family; Region: EamA; pfam00892 271848009761 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 271848009762 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 271848009763 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 271848009764 DNA-binding site [nucleotide binding]; DNA binding site 271848009765 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 271848009766 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848009767 homodimer interface [polypeptide binding]; other site 271848009768 catalytic residue [active] 271848009769 heat shock protein 90; Provisional; Region: PRK05218 271848009770 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848009771 ATP binding site [chemical binding]; other site 271848009772 Mg2+ binding site [ion binding]; other site 271848009773 G-X-G motif; other site 271848009774 Chorismate lyase; Region: Chor_lyase; cl01230 271848009775 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 271848009776 putative active site [active] 271848009777 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 271848009778 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 271848009779 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 271848009780 Na binding site [ion binding]; other site 271848009781 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 271848009782 dimer interface [polypeptide binding]; other site 271848009783 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 271848009784 transaldolase-like protein; Provisional; Region: PTZ00411 271848009785 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 271848009786 active site 271848009787 dimer interface [polypeptide binding]; other site 271848009788 catalytic residue [active] 271848009789 benzoate transporter; Region: benE; TIGR00843 271848009790 Benzoate membrane transport protein; Region: BenE; pfam03594 271848009791 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 271848009792 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 271848009793 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848009794 Walker A motif; other site 271848009795 ATP binding site [chemical binding]; other site 271848009796 Walker B motif; other site 271848009797 arginine finger; other site 271848009798 Cytochrome c553 [Energy production and conversion]; Region: COG2863 271848009799 Cytochrome c; Region: Cytochrom_C; cl11414 271848009800 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 271848009801 EamA-like transporter family; Region: EamA; pfam00892 271848009802 EamA-like transporter family; Region: EamA; pfam00892 271848009803 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 271848009804 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 271848009805 minor groove reading motif; other site 271848009806 helix-hairpin-helix signature motif; other site 271848009807 substrate binding pocket [chemical binding]; other site 271848009808 active site 271848009809 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 271848009810 ferredoxin; Provisional; Region: PRK06991 271848009811 Putative Fe-S cluster; Region: FeS; pfam04060 271848009812 4Fe-4S binding domain; Region: Fer4; pfam00037 271848009813 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 271848009814 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 271848009815 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 271848009816 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 271848009817 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 271848009818 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 271848009819 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 271848009820 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 271848009821 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 271848009822 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 271848009823 META domain; Region: META; pfam03724 271848009824 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 271848009825 TrkA-N domain; Region: TrkA_N; pfam02254 271848009826 ATP-grasp domain; Region: ATP-grasp; pfam02222 271848009827 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 271848009828 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 271848009829 DEAD-like helicases superfamily; Region: DEXDc; smart00487 271848009830 ATP binding site [chemical binding]; other site 271848009831 Mg++ binding site [ion binding]; other site 271848009832 motif III; other site 271848009833 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 271848009834 nucleotide binding region [chemical binding]; other site 271848009835 ATP-binding site [chemical binding]; other site 271848009836 glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838 271848009837 active site 271848009838 HIGH motif; other site 271848009839 nucleotide binding site [chemical binding]; other site 271848009840 KMSKS motif; other site 271848009841 rhodanese superfamily protein; Provisional; Region: PRK05320 271848009842 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 271848009843 active site residue [active] 271848009844 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 271848009845 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 271848009846 putative active site [active] 271848009847 putative PHP Thumb interface [polypeptide binding]; other site 271848009848 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 271848009849 generic binding surface II; other site 271848009850 generic binding surface I; other site 271848009851 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 271848009852 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 271848009853 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 271848009854 Walker A/P-loop; other site 271848009855 ATP binding site [chemical binding]; other site 271848009856 Q-loop/lid; other site 271848009857 ABC transporter signature motif; other site 271848009858 Walker B; other site 271848009859 D-loop; other site 271848009860 H-loop/switch region; other site 271848009861 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 271848009862 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 271848009863 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 271848009864 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 271848009865 putative active site [active] 271848009866 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 271848009867 O-Antigen ligase; Region: Wzy_C; pfam04932 271848009868 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 271848009869 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 271848009870 putative ADP-binding pocket [chemical binding]; other site 271848009871 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 271848009872 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 271848009873 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 271848009874 putative active site [active] 271848009875 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 271848009876 putative metal binding site; other site 271848009877 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 271848009878 Major Facilitator Superfamily; Region: MFS_1; pfam07690 271848009879 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 271848009880 Uncharacterized conserved protein [Function unknown]; Region: COG2128 271848009881 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 271848009882 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 271848009883 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 271848009884 DNA binding residues [nucleotide binding] 271848009885 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848009886 dimerization interface [polypeptide binding]; other site 271848009887 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848009888 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848009889 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 271848009890 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 271848009891 Lipocalin-like domain; Region: Lipocalin_5; pfam13924 271848009892 phospholipase C accessory protein PlcR; Region: plc_access_R; TIGR03398 271848009893 Pectinacetylesterase; Region: PAE; pfam03283 271848009894 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 271848009895 ribonuclease G; Provisional; Region: PRK11712 271848009896 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 271848009897 homodimer interface [polypeptide binding]; other site 271848009898 oligonucleotide binding site [chemical binding]; other site 271848009899 Maf-like protein; Reviewed; Region: PRK01839 271848009900 putative active site [active] 271848009901 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 271848009902 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 271848009903 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 271848009904 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 271848009905 active site 271848009906 (T/H)XGH motif; other site 271848009907 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 271848009908 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 271848009909 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 271848009910 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 271848009911 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 271848009912 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 271848009913 hypothetical protein; Validated; Region: PRK00110 271848009914 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 271848009915 active site 271848009916 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 271848009917 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 271848009918 putative NAD(P) binding site [chemical binding]; other site 271848009919 putative active site [active] 271848009920 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 271848009921 active site 271848009922 dimer interfaces [polypeptide binding]; other site 271848009923 catalytic residues [active] 271848009924 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 271848009925 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 271848009926 NADP binding site [chemical binding]; other site 271848009927 dimer interface [polypeptide binding]; other site 271848009928 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 271848009929 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 271848009930 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 271848009931 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 271848009932 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 271848009933 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 271848009934 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 271848009935 Ligand Binding Site [chemical binding]; other site 271848009936 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 271848009937 GAF domain; Region: GAF_3; pfam13492 271848009938 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271848009939 dimer interface [polypeptide binding]; other site 271848009940 phosphorylation site [posttranslational modification] 271848009941 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848009942 ATP binding site [chemical binding]; other site 271848009943 Mg2+ binding site [ion binding]; other site 271848009944 G-X-G motif; other site 271848009945 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 271848009946 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848009947 active site 271848009948 phosphorylation site [posttranslational modification] 271848009949 intermolecular recognition site; other site 271848009950 dimerization interface [polypeptide binding]; other site 271848009951 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 271848009952 DNA binding site [nucleotide binding] 271848009953 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 271848009954 Domain of unknown function (DUF333); Region: DUF333; pfam03891 271848009955 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 271848009956 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 271848009957 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 271848009958 FtsX-like permease family; Region: FtsX; pfam02687 271848009959 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 271848009960 apolar tunnel; other site 271848009961 heme binding site [chemical binding]; other site 271848009962 dimerization interface [polypeptide binding]; other site 271848009963 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 271848009964 amidase; Provisional; Region: PRK07042 271848009965 Amidase; Region: Amidase; cl11426 271848009966 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848009967 metabolite-proton symporter; Region: 2A0106; TIGR00883 271848009968 putative substrate translocation pore; other site 271848009969 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 271848009970 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 271848009971 glucose-1-dehydrogenase; Provisional; Region: PRK06947 271848009972 classical (c) SDRs; Region: SDR_c; cd05233 271848009973 NAD(P) binding site [chemical binding]; other site 271848009974 active site 271848009975 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 271848009976 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 271848009977 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 271848009978 Bacterial transcriptional repressor; Region: TetR; pfam13972 271848009979 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 271848009980 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 271848009981 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 271848009982 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 271848009983 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 271848009984 putative active site [active] 271848009985 putative metal binding site [ion binding]; other site 271848009986 RDD family; Region: RDD; pfam06271 271848009987 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 271848009988 Protein of unknown function (DUF3619); Region: DUF3619; pfam12279 271848009989 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 271848009990 RNA polymerase factor sigma-70; Validated; Region: PRK09047 271848009991 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 271848009992 DNA binding residues [nucleotide binding] 271848009993 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06965 271848009994 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 271848009995 PYR/PP interface [polypeptide binding]; other site 271848009996 dimer interface [polypeptide binding]; other site 271848009997 TPP binding site [chemical binding]; other site 271848009998 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 271848009999 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 271848010000 TPP-binding site [chemical binding]; other site 271848010001 dimer interface [polypeptide binding]; other site 271848010002 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 271848010003 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 271848010004 putative valine binding site [chemical binding]; other site 271848010005 dimer interface [polypeptide binding]; other site 271848010006 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 271848010007 ketol-acid reductoisomerase; Provisional; Region: PRK05479 271848010008 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 271848010009 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 271848010010 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 271848010011 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 271848010012 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 271848010013 2-isopropylmalate synthase; Validated; Region: PRK00915 271848010014 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 271848010015 active site 271848010016 catalytic residues [active] 271848010017 metal binding site [ion binding]; metal-binding site 271848010018 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 271848010019 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 271848010020 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 271848010021 Sulfate transporter family; Region: Sulfate_transp; pfam00916 271848010022 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 271848010023 active site clefts [active] 271848010024 zinc binding site [ion binding]; other site 271848010025 dimer interface [polypeptide binding]; other site 271848010026 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 271848010027 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329 271848010028 putative ligand binding site [chemical binding]; other site 271848010029 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 271848010030 16S/18S rRNA binding site [nucleotide binding]; other site 271848010031 S13e-L30e interaction site [polypeptide binding]; other site 271848010032 25S rRNA binding site [nucleotide binding]; other site 271848010033 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 271848010034 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 271848010035 RNase E interface [polypeptide binding]; other site 271848010036 trimer interface [polypeptide binding]; other site 271848010037 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 271848010038 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 271848010039 RNase E interface [polypeptide binding]; other site 271848010040 trimer interface [polypeptide binding]; other site 271848010041 active site 271848010042 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 271848010043 putative nucleic acid binding region [nucleotide binding]; other site 271848010044 G-X-X-G motif; other site 271848010045 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 271848010046 RNA binding site [nucleotide binding]; other site 271848010047 domain interface; other site 271848010048 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 271848010049 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 271848010050 NAD(P) binding site [chemical binding]; other site 271848010051 triosephosphate isomerase; Provisional; Region: PRK14567 271848010052 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 271848010053 substrate binding site [chemical binding]; other site 271848010054 dimer interface [polypeptide binding]; other site 271848010055 catalytic triad [active] 271848010056 Preprotein translocase SecG subunit; Region: SecG; pfam03840 271848010057 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 271848010058 NADH dehydrogenase subunit B; Validated; Region: PRK06411 271848010059 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 271848010060 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 271848010061 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 271848010062 NADH dehydrogenase subunit D; Validated; Region: PRK06075 271848010063 NADH dehydrogenase subunit E; Validated; Region: PRK07539 271848010064 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 271848010065 putative dimer interface [polypeptide binding]; other site 271848010066 [2Fe-2S] cluster binding site [ion binding]; other site 271848010067 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 271848010068 SLBB domain; Region: SLBB; pfam10531 271848010069 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 271848010070 NADH dehydrogenase subunit G; Validated; Region: PRK09129 271848010071 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 271848010072 catalytic loop [active] 271848010073 iron binding site [ion binding]; other site 271848010074 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 271848010075 MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772 271848010076 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 271848010077 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 271848010078 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 271848010079 4Fe-4S binding domain; Region: Fer4; pfam00037 271848010080 4Fe-4S binding domain; Region: Fer4; pfam00037 271848010081 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 271848010082 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 271848010083 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 271848010084 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 271848010085 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 271848010086 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 271848010087 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 271848010088 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 271848010089 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 271848010090 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 271848010091 Protein of unknown function (DUF2818); Region: DUF2818; pfam10993 271848010092 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 271848010093 dimer interface [polypeptide binding]; other site 271848010094 ADP-ribose binding site [chemical binding]; other site 271848010095 active site 271848010096 nudix motif; other site 271848010097 metal binding site [ion binding]; metal-binding site 271848010098 Protein of unknown function (DUF1178); Region: DUF1178; pfam06676 271848010099 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 271848010100 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 271848010101 FAD binding site [chemical binding]; other site 271848010102 substrate binding site [chemical binding]; other site 271848010103 catalytic base [active] 271848010104 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 271848010105 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 271848010106 active site 271848010107 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 271848010108 putative active site [active] 271848010109 putative catalytic site [active] 271848010110 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 271848010111 putative active site [active] 271848010112 putative catalytic site [active] 271848010113 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 271848010114 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 271848010115 FAD binding site [chemical binding]; other site 271848010116 substrate binding site [chemical binding]; other site 271848010117 catalytic base [active] 271848010118 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 271848010119 putative active site [active] 271848010120 putative substrate binding site [chemical binding]; other site 271848010121 ATP binding site [chemical binding]; other site 271848010122 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 271848010123 catalytic core [active] 271848010124 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 271848010125 enoyl-CoA hydratase; Provisional; Region: PRK07511 271848010126 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 271848010127 substrate binding site [chemical binding]; other site 271848010128 oxyanion hole (OAH) forming residues; other site 271848010129 trimer interface [polypeptide binding]; other site 271848010130 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 271848010131 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 271848010132 C-terminal domain interface [polypeptide binding]; other site 271848010133 GSH binding site (G-site) [chemical binding]; other site 271848010134 dimer interface [polypeptide binding]; other site 271848010135 C-terminal, alpha helical domain of an unknown subfamily 9 of Glutathione S-transferases; Region: GST_C_9; cd10424 271848010136 putative N-terminal domain interface [polypeptide binding]; other site 271848010137 putative dimer interface [polypeptide binding]; other site 271848010138 putative substrate binding pocket (H-site) [chemical binding]; other site 271848010139 methionine aminotransferase; Validated; Region: PRK09082 271848010140 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 271848010141 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848010142 homodimer interface [polypeptide binding]; other site 271848010143 catalytic residue [active] 271848010144 PIN domain; Region: PIN_3; pfam13470 271848010145 PIN domain; Region: PIN_3; cl17397 271848010146 hypothetical protein; Validated; Region: PRK02101 271848010147 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 271848010148 Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases; uncharacterized bacterial subgroup; Region: M14_Nna1_like_1; cd06234 271848010149 putative active site [active] 271848010150 Zn binding site [ion binding]; other site 271848010151 Predicted membrane protein [Function unknown]; Region: COG3235 271848010152 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 271848010153 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848010154 active site 271848010155 phosphorylation site [posttranslational modification] 271848010156 intermolecular recognition site; other site 271848010157 dimerization interface [polypeptide binding]; other site 271848010158 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 271848010159 DNA binding residues [nucleotide binding] 271848010160 dimerization interface [polypeptide binding]; other site 271848010161 Protein of unknown function (DUF2863); Region: DUF2863; pfam11062 271848010162 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 271848010163 Transposase; Region: HTH_Tnp_1; pfam01527 271848010164 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 271848010165 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 271848010166 Transposase, Mutator family; Region: Transposase_mut; pfam00872 271848010167 MULE transposase domain; Region: MULE; pfam10551 271848010168 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 271848010169 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 271848010170 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 271848010171 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 271848010172 putative [4Fe-4S] binding site [ion binding]; other site 271848010173 putative molybdopterin cofactor binding site [chemical binding]; other site 271848010174 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 271848010175 putative molybdopterin cofactor binding site; other site 271848010176 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 271848010177 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 271848010178 acyl-activating enzyme (AAE) consensus motif; other site 271848010179 putative AMP binding site [chemical binding]; other site 271848010180 putative active site [active] 271848010181 putative CoA binding site [chemical binding]; other site 271848010182 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 271848010183 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 271848010184 trimer interface [polypeptide binding]; other site 271848010185 eyelet of channel; other site 271848010186 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 271848010187 diiron binding motif [ion binding]; other site 271848010188 cell division protein MraZ; Reviewed; Region: PRK00326 271848010189 MraZ protein; Region: MraZ; pfam02381 271848010190 MraZ protein; Region: MraZ; pfam02381 271848010191 MraW methylase family; Region: Methyltransf_5; cl17771 271848010192 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 271848010193 Cell division protein FtsL; Region: FtsL; pfam04999 271848010194 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 271848010195 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 271848010196 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 271848010197 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 271848010198 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 271848010199 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 271848010200 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 271848010201 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 271848010202 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 271848010203 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 271848010204 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 271848010205 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 271848010206 Mg++ binding site [ion binding]; other site 271848010207 putative catalytic motif [active] 271848010208 putative substrate binding site [chemical binding]; other site 271848010209 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02006 271848010210 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 271848010211 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 271848010212 cell division protein FtsW; Region: ftsW; TIGR02614 271848010213 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 271848010214 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 271848010215 active site 271848010216 homodimer interface [polypeptide binding]; other site 271848010217 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 271848010218 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 271848010219 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 271848010220 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 271848010221 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 271848010222 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 271848010223 ATP-grasp domain; Region: ATP-grasp_4; cl17255 271848010224 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 271848010225 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 271848010226 Cell division protein FtsQ; Region: FtsQ; pfam03799 271848010227 cell division protein FtsA; Region: ftsA; TIGR01174 271848010228 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 271848010229 nucleotide binding site [chemical binding]; other site 271848010230 Cell division protein FtsA; Region: FtsA; pfam14450 271848010231 cell division protein FtsZ; Validated; Region: PRK09330 271848010232 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 271848010233 nucleotide binding site [chemical binding]; other site 271848010234 SulA interaction site; other site 271848010235 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 271848010236 catalytic triad [active] 271848010237 dimer interface [polypeptide binding]; other site 271848010238 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 271848010239 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 271848010240 Protein of unknown function (DUF721); Region: DUF721; pfam05258 271848010241 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 271848010242 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 271848010243 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 271848010244 SEC-C motif; Region: SEC-C; pfam02810 271848010245 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 271848010246 heterotetramer interface [polypeptide binding]; other site 271848010247 active site pocket [active] 271848010248 cleavage site 271848010249 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 271848010250 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848010251 Walker A motif; other site 271848010252 ATP binding site [chemical binding]; other site 271848010253 Walker B motif; other site 271848010254 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 271848010255 active site 271848010256 8-oxo-dGMP binding site [chemical binding]; other site 271848010257 nudix motif; other site 271848010258 metal binding site [ion binding]; metal-binding site 271848010259 Domain of unknown function (DUF329); Region: DUF329; pfam03884 271848010260 hypothetical protein; Provisional; Region: PRK05287 271848010261 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 271848010262 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 271848010263 CoA-binding site [chemical binding]; other site 271848010264 ATP-binding [chemical binding]; other site 271848010265 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 271848010266 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 271848010267 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 271848010268 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 271848010269 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 271848010270 Type II/IV secretion system protein; Region: T2SE; pfam00437 271848010271 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 271848010272 Walker A motif; other site 271848010273 ATP binding site [chemical binding]; other site 271848010274 Walker B motif; other site 271848010275 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 271848010276 Domain of unknown function DUF21; Region: DUF21; pfam01595 271848010277 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 271848010278 Transporter associated domain; Region: CorC_HlyC; smart01091 271848010279 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 271848010280 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 271848010281 substrate binding pocket [chemical binding]; other site 271848010282 chain length determination region; other site 271848010283 substrate-Mg2+ binding site; other site 271848010284 catalytic residues [active] 271848010285 aspartate-rich region 1; other site 271848010286 active site lid residues [active] 271848010287 aspartate-rich region 2; other site 271848010288 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 271848010289 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 271848010290 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 271848010291 GTPase CgtA; Reviewed; Region: obgE; PRK12298 271848010292 GTP1/OBG; Region: GTP1_OBG; pfam01018 271848010293 Obg GTPase; Region: Obg; cd01898 271848010294 G1 box; other site 271848010295 GTP/Mg2+ binding site [chemical binding]; other site 271848010296 Switch I region; other site 271848010297 G2 box; other site 271848010298 G3 box; other site 271848010299 Switch II region; other site 271848010300 G4 box; other site 271848010301 G5 box; other site 271848010302 gamma-glutamyl kinase; Provisional; Region: PRK05429 271848010303 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 271848010304 nucleotide binding site [chemical binding]; other site 271848010305 homotetrameric interface [polypeptide binding]; other site 271848010306 putative phosphate binding site [ion binding]; other site 271848010307 putative allosteric binding site; other site 271848010308 PUA domain; Region: PUA; pfam01472 271848010309 CNP1-like family; Region: CNP1; pfam08750 271848010310 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 271848010311 putative active site [active] 271848010312 Ap4A binding site [chemical binding]; other site 271848010313 nudix motif; other site 271848010314 putative metal binding site [ion binding]; other site 271848010315 prolyl-tRNA synthetase; Provisional; Region: PRK09194 271848010316 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 271848010317 dimer interface [polypeptide binding]; other site 271848010318 motif 1; other site 271848010319 active site 271848010320 motif 2; other site 271848010321 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 271848010322 putative deacylase active site [active] 271848010323 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 271848010324 active site 271848010325 motif 3; other site 271848010326 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 271848010327 anticodon binding site; other site 271848010328 MarC family integral membrane protein; Region: MarC; cl00919 271848010329 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 271848010330 active site 271848010331 signal recognition particle protein; Provisional; Region: PRK10867 271848010332 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 271848010333 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 271848010334 P loop; other site 271848010335 GTP binding site [chemical binding]; other site 271848010336 Signal peptide binding domain; Region: SRP_SPB; pfam02978 271848010337 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 271848010338 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 271848010339 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 271848010340 amidase catalytic site [active] 271848010341 Zn binding residues [ion binding]; other site 271848010342 substrate binding site [chemical binding]; other site 271848010343 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 271848010344 ATP cone domain; Region: ATP-cone; pfam03477 271848010345 Class I ribonucleotide reductase; Region: RNR_I; cd01679 271848010346 active site 271848010347 dimer interface [polypeptide binding]; other site 271848010348 catalytic residues [active] 271848010349 effector binding site; other site 271848010350 R2 peptide binding site; other site 271848010351 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 271848010352 dimer interface [polypeptide binding]; other site 271848010353 putative radical transfer pathway; other site 271848010354 diiron center [ion binding]; other site 271848010355 tyrosyl radical; other site 271848010356 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 271848010357 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 271848010358 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 271848010359 substrate binding site [chemical binding]; other site 271848010360 ATP binding site [chemical binding]; other site 271848010361 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 271848010362 dimer interface [polypeptide binding]; other site 271848010363 catalytic triad [active] 271848010364 peroxidatic and resolving cysteines [active] 271848010365 MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098 271848010366 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 271848010367 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 271848010368 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848010369 S-adenosylmethionine binding site [chemical binding]; other site 271848010370 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 271848010371 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 271848010372 ATP-grasp domain; Region: ATP-grasp_4; cl17255 271848010373 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 271848010374 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 271848010375 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 271848010376 carboxyltransferase (CT) interaction site; other site 271848010377 biotinylation site [posttranslational modification]; other site 271848010378 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 271848010379 Dehydroquinase class II; Region: DHquinase_II; pfam01220 271848010380 active site 271848010381 trimer interface [polypeptide binding]; other site 271848010382 dimer interface [polypeptide binding]; other site 271848010383 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 271848010384 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 271848010385 catalytic residues [active] 271848010386 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 271848010387 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 271848010388 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 271848010389 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 271848010390 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 271848010391 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 271848010392 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 271848010393 RNB domain; Region: RNB; pfam00773 271848010394 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 271848010395 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 271848010396 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 271848010397 shikimate binding site; other site 271848010398 NAD(P) binding site [chemical binding]; other site 271848010399 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 271848010400 Transglycosylase; Region: Transgly; cl17702 271848010401 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 271848010402 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 271848010403 Transcriptional regulator [Transcription]; Region: IclR; COG1414 271848010404 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 271848010405 Bacterial transcriptional regulator; Region: IclR; pfam01614 271848010406 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 271848010407 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 271848010408 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 271848010409 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 271848010410 active site 271848010411 intersubunit interface [polypeptide binding]; other site 271848010412 catalytic residue [active] 271848010413 short chain dehydrogenase; Provisional; Region: PRK07063 271848010414 classical (c) SDRs; Region: SDR_c; cd05233 271848010415 NAD(P) binding site [chemical binding]; other site 271848010416 active site 271848010417 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 271848010418 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 271848010419 ligand binding site [chemical binding]; other site 271848010420 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 271848010421 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 271848010422 Walker A/P-loop; other site 271848010423 ATP binding site [chemical binding]; other site 271848010424 Q-loop/lid; other site 271848010425 ABC transporter signature motif; other site 271848010426 Walker B; other site 271848010427 D-loop; other site 271848010428 H-loop/switch region; other site 271848010429 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 271848010430 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 271848010431 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 271848010432 TM-ABC transporter signature motif; other site 271848010433 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 271848010434 classical (c) SDRs; Region: SDR_c; cd05233 271848010435 NAD(P) binding site [chemical binding]; other site 271848010436 active site 271848010437 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 271848010438 active site 271848010439 catalytic residues [active] 271848010440 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 271848010441 active site 271848010442 dimer interface [polypeptide binding]; other site 271848010443 Competence-damaged protein; Region: CinA; pfam02464 271848010444 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 271848010445 tetramer interfaces [polypeptide binding]; other site 271848010446 binuclear metal-binding site [ion binding]; other site 271848010447 thiamine monophosphate kinase; Provisional; Region: PRK05731 271848010448 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 271848010449 ATP binding site [chemical binding]; other site 271848010450 dimerization interface [polypeptide binding]; other site 271848010451 malic enzyme; Reviewed; Region: PRK12862 271848010452 Malic enzyme, N-terminal domain; Region: malic; pfam00390 271848010453 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 271848010454 putative NAD(P) binding site [chemical binding]; other site 271848010455 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 271848010456 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 271848010457 active site 271848010458 barstar interaction site; other site 271848010459 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 271848010460 putative RNAase interaction site [polypeptide binding]; other site 271848010461 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 271848010462 RNA methyltransferase, RsmE family; Region: TIGR00046 271848010463 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 271848010464 putative dimer interface [polypeptide binding]; other site 271848010465 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 271848010466 spermidine synthase; Provisional; Region: PRK00811 271848010467 Spermidine synthase [Amino acid transport and metabolism]; Region: SpeE; COG0421 271848010468 transketolase; Reviewed; Region: PRK12753 271848010469 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 271848010470 TPP-binding site [chemical binding]; other site 271848010471 dimer interface [polypeptide binding]; other site 271848010472 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 271848010473 PYR/PP interface [polypeptide binding]; other site 271848010474 dimer interface [polypeptide binding]; other site 271848010475 TPP binding site [chemical binding]; other site 271848010476 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 271848010477 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 271848010478 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 271848010479 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 271848010480 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 271848010481 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848010482 cyanate hydratase; Validated; Region: PRK02866 271848010483 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 271848010484 oligomer interface [polypeptide binding]; other site 271848010485 active site 271848010486 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 271848010487 active site clefts [active] 271848010488 zinc binding site [ion binding]; other site 271848010489 dimer interface [polypeptide binding]; other site 271848010490 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 271848010491 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848010492 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425 271848010493 dimerization interface [polypeptide binding]; other site 271848010494 Transcriptional regulators [Transcription]; Region: FadR; COG2186 271848010495 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 271848010496 DNA-binding site [nucleotide binding]; DNA binding site 271848010497 FCD domain; Region: FCD; pfam07729 271848010498 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK13027 271848010499 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 271848010500 allantoicase; Provisional; Region: PRK13257 271848010501 Allantoicase repeat; Region: Allantoicase; pfam03561 271848010502 Allantoicase repeat; Region: Allantoicase; pfam03561 271848010503 ureidoglycolate hydrolase; Provisional; Region: PRK13395 271848010504 ferric uptake regulator; Provisional; Region: fur; PRK09462 271848010505 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 271848010506 metal binding site 2 [ion binding]; metal-binding site 271848010507 putative DNA binding helix; other site 271848010508 metal binding site 1 [ion binding]; metal-binding site 271848010509 dimer interface [polypeptide binding]; other site 271848010510 structural Zn2+ binding site [ion binding]; other site 271848010511 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 271848010512 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 271848010513 dihydrodipicolinate reductase; Provisional; Region: PRK00048 271848010514 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 271848010515 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 271848010516 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618 271848010517 TolR protein; Region: tolR; TIGR02801 271848010518 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 271848010519 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 271848010520 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 271848010521 HIGH motif; other site 271848010522 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 271848010523 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 271848010524 active site 271848010525 KMSKS motif; other site 271848010526 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 271848010527 tRNA binding surface [nucleotide binding]; other site 271848010528 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 271848010529 Lipopolysaccharide-assembly; Region: LptE; cl01125 271848010530 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 271848010531 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 271848010532 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 271848010533 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 271848010534 putative catalytic cysteine [active] 271848010535 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 271848010536 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 271848010537 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 271848010538 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 271848010539 putative active site [active] 271848010540 phosphogluconate dehydratase; Validated; Region: PRK09054 271848010541 6-phosphogluconate dehydratase; Region: edd; TIGR01196 271848010542 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 271848010543 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 271848010544 active site 271848010545 intersubunit interface [polypeptide binding]; other site 271848010546 catalytic residue [active] 271848010547 fructuronate transporter; Provisional; Region: PRK10034; cl15264 271848010548 GntP family permease; Region: GntP_permease; pfam02447 271848010549 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 271848010550 ATP-binding site [chemical binding]; other site 271848010551 Gluconate-6-phosphate binding site [chemical binding]; other site 271848010552 Shikimate kinase; Region: SKI; pfam01202 271848010553 adenylosuccinate lyase; Provisional; Region: PRK09285 271848010554 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 271848010555 tetramer interface [polypeptide binding]; other site 271848010556 active site 271848010557 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 271848010558 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848010559 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848010560 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848010561 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 271848010562 dimerization interface [polypeptide binding]; other site 271848010563 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 271848010564 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 271848010565 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 271848010566 NAD(P) binding site [chemical binding]; other site 271848010567 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 271848010568 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 271848010569 substrate binding pocket [chemical binding]; other site 271848010570 membrane-bound complex binding site; other site 271848010571 hinge residues; other site 271848010572 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 271848010573 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848010574 dimer interface [polypeptide binding]; other site 271848010575 conserved gate region; other site 271848010576 putative PBP binding loops; other site 271848010577 ABC-ATPase subunit interface; other site 271848010578 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 271848010579 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848010580 dimer interface [polypeptide binding]; other site 271848010581 conserved gate region; other site 271848010582 putative PBP binding loops; other site 271848010583 ABC-ATPase subunit interface; other site 271848010584 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 271848010585 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 271848010586 Walker A/P-loop; other site 271848010587 ATP binding site [chemical binding]; other site 271848010588 Q-loop/lid; other site 271848010589 ABC transporter signature motif; other site 271848010590 Walker B; other site 271848010591 D-loop; other site 271848010592 H-loop/switch region; other site 271848010593 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 271848010594 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 271848010595 putative active site [active] 271848010596 putative dimer interface [polypeptide binding]; other site 271848010597 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 271848010598 active site 271848010599 substrate binding pocket [chemical binding]; other site 271848010600 dimer interface [polypeptide binding]; other site 271848010601 Protein of unknown function (DUF3025); Region: DUF3025; pfam11227 271848010602 OsmC-like protein; Region: OsmC; cl00767 271848010603 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 271848010604 23S rRNA interface [nucleotide binding]; other site 271848010605 L3 interface [polypeptide binding]; other site 271848010606 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 271848010607 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 271848010608 Cupin; Region: Cupin_6; pfam12852 271848010609 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 271848010610 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848010611 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 271848010612 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 271848010613 C-terminal domain interface [polypeptide binding]; other site 271848010614 GSH binding site (G-site) [chemical binding]; other site 271848010615 dimer interface [polypeptide binding]; other site 271848010616 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 271848010617 N-terminal domain interface [polypeptide binding]; other site 271848010618 dimer interface [polypeptide binding]; other site 271848010619 substrate binding pocket (H-site) [chemical binding]; other site 271848010620 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 271848010621 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 271848010622 C-terminal domain interface [polypeptide binding]; other site 271848010623 GSH binding site (G-site) [chemical binding]; other site 271848010624 dimer interface [polypeptide binding]; other site 271848010625 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 271848010626 N-terminal domain interface [polypeptide binding]; other site 271848010627 dimer interface [polypeptide binding]; other site 271848010628 substrate binding pocket (H-site) [chemical binding]; other site 271848010629 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 271848010630 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 271848010631 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 271848010632 active site 271848010633 HIGH motif; other site 271848010634 dimer interface [polypeptide binding]; other site 271848010635 KMSKS motif; other site 271848010636 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 271848010637 RNA binding surface [nucleotide binding]; other site 271848010638 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 271848010639 putative active site [active] 271848010640 dimerization interface [polypeptide binding]; other site 271848010641 putative tRNAtyr binding site [nucleotide binding]; other site 271848010642 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 271848010643 catalytic core [active] 271848010644 Putative ParB-like nuclease; Region: ParBc_2; cl17538 271848010645 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 271848010646 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 271848010647 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848010648 Walker A motif; other site 271848010649 ATP binding site [chemical binding]; other site 271848010650 Walker B motif; other site 271848010651 arginine finger; other site 271848010652 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 271848010653 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 271848010654 RuvA N terminal domain; Region: RuvA_N; pfam01330 271848010655 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 271848010656 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 271848010657 active site 271848010658 putative DNA-binding cleft [nucleotide binding]; other site 271848010659 dimer interface [polypeptide binding]; other site 271848010660 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 271848010661 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 271848010662 purine monophosphate binding site [chemical binding]; other site 271848010663 dimer interface [polypeptide binding]; other site 271848010664 putative catalytic residues [active] 271848010665 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 271848010666 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 271848010667 DNA-binding protein Fis; Provisional; Region: PRK01905 271848010668 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 271848010669 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 271848010670 FMN binding site [chemical binding]; other site 271848010671 active site 271848010672 catalytic residues [active] 271848010673 substrate binding site [chemical binding]; other site 271848010674 hypothetical protein; Provisional; Region: PRK06996 271848010675 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 271848010676 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 271848010677 proline aminopeptidase P II; Provisional; Region: PRK10879 271848010678 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 271848010679 active site 271848010680 putative glutathione S-transferase; Provisional; Region: PRK10357 271848010681 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 271848010682 putative C-terminal domain interface [polypeptide binding]; other site 271848010683 putative GSH binding site (G-site) [chemical binding]; other site 271848010684 putative dimer interface [polypeptide binding]; other site 271848010685 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 271848010686 dimer interface [polypeptide binding]; other site 271848010687 N-terminal domain interface [polypeptide binding]; other site 271848010688 putative substrate binding pocket (H-site) [chemical binding]; other site 271848010689 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 271848010690 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 271848010691 active site 271848010692 FMN binding site [chemical binding]; other site 271848010693 substrate binding site [chemical binding]; other site 271848010694 3Fe-4S cluster binding site [ion binding]; other site 271848010695 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 271848010696 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 271848010697 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 271848010698 nudix motif; other site 271848010699 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 271848010700 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 271848010701 ligand binding site [chemical binding]; other site 271848010702 homodimer interface [polypeptide binding]; other site 271848010703 NAD(P) binding site [chemical binding]; other site 271848010704 trimer interface B [polypeptide binding]; other site 271848010705 trimer interface A [polypeptide binding]; other site 271848010706 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 271848010707 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 271848010708 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 271848010709 Predicted transcriptional regulator [Transcription]; Region: COG2378 271848010710 HTH domain; Region: HTH_11; pfam08279 271848010711 WYL domain; Region: WYL; pfam13280 271848010712 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 271848010713 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 271848010714 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 271848010715 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 271848010716 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 271848010717 Site-specific recombinase; Region: SpecificRecomb; pfam10136 271848010718 Protein of unknown function (DUF330); Region: DUF330; pfam03886 271848010719 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 271848010720 mce related protein; Region: MCE; pfam02470 271848010721 mce related protein; Region: MCE; pfam02470 271848010722 Paraquat-inducible protein A; Region: PqiA; pfam04403 271848010723 Paraquat-inducible protein A; Region: PqiA; pfam04403 271848010724 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 271848010725 YceI-like domain; Region: YceI; smart00867 271848010726 Uncharacterized conserved protein [Function unknown]; Region: COG2353 271848010727 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848010728 metabolite-proton symporter; Region: 2A0106; TIGR00883 271848010729 putative substrate translocation pore; other site 271848010730 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 271848010731 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 271848010732 Protein export membrane protein; Region: SecD_SecF; pfam02355 271848010733 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 271848010734 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 271848010735 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 271848010736 Protein export membrane protein; Region: SecD_SecF; cl14618 271848010737 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 271848010738 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 271848010739 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 271848010740 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 271848010741 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 271848010742 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 271848010743 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 271848010744 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 271848010745 generic binding surface II; other site 271848010746 ssDNA binding site; other site 271848010747 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 271848010748 ATP binding site [chemical binding]; other site 271848010749 putative Mg++ binding site [ion binding]; other site 271848010750 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 271848010751 nucleotide binding region [chemical binding]; other site 271848010752 ATP-binding site [chemical binding]; other site 271848010753 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848010754 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848010755 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 271848010756 dimerization interface [polypeptide binding]; other site 271848010757 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 271848010758 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 271848010759 dimer interface [polypeptide binding]; other site 271848010760 active site 271848010761 heme binding site [chemical binding]; other site 271848010762 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 271848010763 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 271848010764 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 271848010765 dimerization interface [polypeptide binding]; other site 271848010766 DPS ferroxidase diiron center [ion binding]; other site 271848010767 ion pore; other site 271848010768 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 271848010769 UbiA prenyltransferase family; Region: UbiA; pfam01040 271848010770 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 271848010771 pyrroline-5-carboxylate reductase; Region: PLN02688 271848010772 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 271848010773 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 271848010774 catalytic residue [active] 271848010775 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 271848010776 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 271848010777 Cysteine-rich domain; Region: CCG; pfam02754 271848010778 Cysteine-rich domain; Region: CCG; pfam02754 271848010779 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 271848010780 FAD binding domain; Region: FAD_binding_4; pfam01565 271848010781 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 271848010782 FAD binding domain; Region: FAD_binding_4; pfam01565 271848010783 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 271848010784 FAD binding domain; Region: FAD_binding_4; pfam01565 271848010785 ATP:cob(I)alamin adenosyltransferase; Region: PduO_Nterm; TIGR00636 271848010786 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 271848010787 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 271848010788 heme-binding site [chemical binding]; other site 271848010789 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 271848010790 FAD binding pocket [chemical binding]; other site 271848010791 FAD binding motif [chemical binding]; other site 271848010792 phosphate binding motif [ion binding]; other site 271848010793 beta-alpha-beta structure motif; other site 271848010794 NAD binding pocket [chemical binding]; other site 271848010795 Heme binding pocket [chemical binding]; other site 271848010796 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 271848010797 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 271848010798 protease TldD; Provisional; Region: tldD; PRK10735 271848010799 nitrilase; Region: PLN02798 271848010800 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 271848010801 putative active site [active] 271848010802 catalytic triad [active] 271848010803 dimer interface [polypeptide binding]; other site 271848010804 TIGR02099 family protein; Region: TIGR02099 271848010805 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 271848010806 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 271848010807 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 271848010808 metal binding triad; other site 271848010809 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 271848010810 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 271848010811 metal binding triad; other site 271848010812 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 271848010813 recombination and repair protein; Provisional; Region: PRK10869 271848010814 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 271848010815 Walker A/P-loop; other site 271848010816 ATP binding site [chemical binding]; other site 271848010817 Q-loop/lid; other site 271848010818 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 271848010819 ABC transporter signature motif; other site 271848010820 Walker B; other site 271848010821 D-loop; other site 271848010822 H-loop/switch region; other site 271848010823 NAD(+)/NADH kinase family protein; Provisional; Region: ppnK; PRK02155 271848010824 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 271848010825 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 271848010826 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 271848010827 ferrochelatase; Reviewed; Region: hemH; PRK00035 271848010828 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 271848010829 C-terminal domain interface [polypeptide binding]; other site 271848010830 active site 271848010831 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 271848010832 active site 271848010833 N-terminal domain interface [polypeptide binding]; other site 271848010834 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 271848010835 RNA binding surface [nucleotide binding]; other site 271848010836 GrpE; Region: GrpE; pfam01025 271848010837 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 271848010838 dimer interface [polypeptide binding]; other site 271848010839 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 271848010840 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 271848010841 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 271848010842 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 271848010843 nucleotide binding site [chemical binding]; other site 271848010844 chaperone protein DnaJ; Provisional; Region: PRK10767 271848010845 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 271848010846 HSP70 interaction site [polypeptide binding]; other site 271848010847 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 271848010848 Zn binding sites [ion binding]; other site 271848010849 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 271848010850 dimer interface [polypeptide binding]; other site 271848010851 chorismate binding enzyme; Region: Chorismate_bind; cl10555 271848010852 hypothetical protein; Provisional; Region: PRK07546 271848010853 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 271848010854 homodimer interface [polypeptide binding]; other site 271848010855 substrate-cofactor binding pocket; other site 271848010856 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848010857 catalytic residue [active] 271848010858 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 271848010859 oligomerization interface [polypeptide binding]; other site 271848010860 active site 271848010861 metal binding site [ion binding]; metal-binding site 271848010862 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 271848010863 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 271848010864 Substrate-binding site [chemical binding]; other site 271848010865 Substrate specificity [chemical binding]; other site 271848010866 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 271848010867 catalytic center binding site [active] 271848010868 ATP binding site [chemical binding]; other site 271848010869 poly(A) polymerase; Region: pcnB; TIGR01942 271848010870 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 271848010871 active site 271848010872 NTP binding site [chemical binding]; other site 271848010873 metal binding triad [ion binding]; metal-binding site 271848010874 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 271848010875 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 271848010876 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 271848010877 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 271848010878 DnaA regulatory inactivator Hda; Validated; Region: PRK08903 271848010879 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 271848010880 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 271848010881 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 271848010882 dimerization interface [polypeptide binding]; other site 271848010883 putative ATP binding site [chemical binding]; other site 271848010884 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 271848010885 SnoaL-like domain; Region: SnoaL_3; pfam13474 271848010886 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 271848010887 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 271848010888 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 271848010889 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848010890 ATP binding site [chemical binding]; other site 271848010891 Mg2+ binding site [ion binding]; other site 271848010892 G-X-G motif; other site 271848010893 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 271848010894 ATP binding site [chemical binding]; other site 271848010895 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 271848010896 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 271848010897 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 271848010898 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 271848010899 Mechanosensitive ion channel; Region: MS_channel; pfam00924 271848010900 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 271848010901 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 271848010902 putative active site [active] 271848010903 putative dimer interface [polypeptide binding]; other site 271848010904 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 271848010905 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 271848010906 Substrate binding site; other site 271848010907 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 271848010908 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 271848010909 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 271848010910 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 271848010911 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 271848010912 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 271848010913 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 271848010914 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 271848010915 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 271848010916 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 271848010917 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 271848010918 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 271848010919 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 271848010920 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 271848010921 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 271848010922 NADP-binding site; other site 271848010923 homotetramer interface [polypeptide binding]; other site 271848010924 substrate binding site [chemical binding]; other site 271848010925 homodimer interface [polypeptide binding]; other site 271848010926 active site 271848010927 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 271848010928 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 271848010929 NADP-binding site; other site 271848010930 homotetramer interface [polypeptide binding]; other site 271848010931 substrate binding site [chemical binding]; other site 271848010932 homodimer interface [polypeptide binding]; other site 271848010933 active site 271848010934 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 271848010935 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 271848010936 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 271848010937 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 271848010938 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 271848010939 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 271848010940 Walker A/P-loop; other site 271848010941 ATP binding site [chemical binding]; other site 271848010942 Q-loop/lid; other site 271848010943 ABC transporter signature motif; other site 271848010944 Walker B; other site 271848010945 D-loop; other site 271848010946 H-loop/switch region; other site 271848010947 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 271848010948 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 271848010949 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 271848010950 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 271848010951 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 271848010952 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848010953 NAD(P) binding site [chemical binding]; other site 271848010954 active site 271848010955 Sulfatase; Region: Sulfatase; pfam00884 271848010956 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 271848010957 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 271848010958 active site 271848010959 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 271848010960 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 271848010961 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 271848010962 Methyltransferase domain; Region: Methyltransf_23; pfam13489 271848010963 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848010964 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 271848010965 Enoylreductase; Region: PKS_ER; smart00829 271848010966 NAD(P) binding site [chemical binding]; other site 271848010967 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 271848010968 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 271848010969 putative NADP binding site [chemical binding]; other site 271848010970 active site 271848010971 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 271848010972 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: PRK13187 271848010973 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 271848010974 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 271848010975 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 271848010976 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 271848010977 catalytic residue [active] 271848010978 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 271848010979 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 271848010980 putative carbohydrate binding site [chemical binding]; other site 271848010981 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 271848010982 active site 271848010983 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 271848010984 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848010985 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848010986 CoA-binding domain; Region: CoA_binding_3; pfam13727 271848010987 Bacterial sugar transferase; Region: Bac_transf; pfam02397 271848010988 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 271848010989 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 271848010990 SLBB domain; Region: SLBB; pfam10531 271848010991 Low molecular weight phosphatase family; Region: LMWPc; cd00115 271848010992 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 271848010993 active site 271848010994 Chain length determinant protein; Region: Wzz; pfam02706 271848010995 tyrosine kinase; Provisional; Region: PRK11519 271848010996 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region; Region: Glyco_transf_54; pfam04666 271848010997 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 271848010998 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 271848010999 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 271848011000 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 271848011001 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 271848011002 trimer interface [polypeptide binding]; other site 271848011003 active site 271848011004 substrate binding site [chemical binding]; other site 271848011005 CoA binding site [chemical binding]; other site 271848011006 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 271848011007 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 271848011008 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 271848011009 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 271848011010 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK12457 271848011011 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 271848011012 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 271848011013 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 271848011014 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 271848011015 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 271848011016 putative active site [active] 271848011017 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 271848011018 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 271848011019 active site 271848011020 tetramer interface; other site 271848011021 Flagellar transcriptional activator (FlhD); Region: FlhD; cl05012 271848011022 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 271848011023 Fatty acid desaturase; Region: FA_desaturase; pfam00487 271848011024 putative di-iron ligands [ion binding]; other site 271848011025 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 271848011026 Proline dehydrogenase; Region: Pro_dh; cl03282 271848011027 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 271848011028 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 271848011029 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 271848011030 catalytic residue [active] 271848011031 EamA-like transporter family; Region: EamA; pfam00892 271848011032 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 271848011033 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 271848011034 Tetratricopeptide repeat; Region: TPR_6; pfam13174 271848011035 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 271848011036 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 271848011037 ligand binding site [chemical binding]; other site 271848011038 translocation protein TolB; Provisional; Region: tolB; PRK02889 271848011039 TolB amino-terminal domain; Region: TolB_N; pfam04052 271848011040 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 271848011041 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 271848011042 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 271848011043 TolA protein; Region: tolA_full; TIGR02794 271848011044 TonB C terminal; Region: TonB_2; pfam13103 271848011045 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 271848011046 TolR protein; Region: tolR; TIGR02801 271848011047 TolQ protein; Region: tolQ; TIGR02796 271848011048 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 271848011049 active site 271848011050 malonic semialdehyde reductase; Provisional; Region: PRK10538 271848011051 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848011052 NAD(P) binding site [chemical binding]; other site 271848011053 active site 271848011054 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 271848011055 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 271848011056 dimer interface [polypeptide binding]; other site 271848011057 active site 271848011058 glycine-pyridoxal phosphate binding site [chemical binding]; other site 271848011059 folate binding site [chemical binding]; other site 271848011060 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 271848011061 ATP cone domain; Region: ATP-cone; pfam03477 271848011062 Type II transport protein GspH; Region: GspH; pfam12019 271848011063 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 271848011064 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 271848011065 Predicted membrane protein [Function unknown]; Region: COG5393 271848011066 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 271848011067 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 271848011068 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 271848011069 dimer interface [polypeptide binding]; other site 271848011070 decamer (pentamer of dimers) interface [polypeptide binding]; other site 271848011071 catalytic triad [active] 271848011072 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 271848011073 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 271848011074 FAD binding site [chemical binding]; other site 271848011075 substrate binding pocket [chemical binding]; other site 271848011076 catalytic base [active] 271848011077 Transcriptional regulator [Transcription]; Region: IclR; COG1414 271848011078 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 271848011079 Uncharacterized conserved protein [Function unknown]; Region: COG3791 271848011080 EAL domain; Region: EAL; pfam00563 271848011081 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 271848011082 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 271848011083 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 271848011084 benzoate transport; Region: 2A0115; TIGR00895 271848011085 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848011086 putative substrate translocation pore; other site 271848011087 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848011088 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 271848011089 fumarylacetoacetase; Region: PLN02856 271848011090 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 271848011091 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 271848011092 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848011093 Major Facilitator Superfamily; Region: MFS_1; pfam07690 271848011094 putative substrate translocation pore; other site 271848011095 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 271848011096 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848011097 putative substrate translocation pore; other site 271848011098 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 271848011099 putative FMN binding site [chemical binding]; other site 271848011100 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 271848011101 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 271848011102 putative ligand binding site [chemical binding]; other site 271848011103 putative NAD binding site [chemical binding]; other site 271848011104 catalytic site [active] 271848011105 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848011106 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848011107 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 271848011108 putative effector binding pocket; other site 271848011109 dimerization interface [polypeptide binding]; other site 271848011110 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 271848011111 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 271848011112 catalytic residue [active] 271848011113 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 271848011114 EamA-like transporter family; Region: EamA; pfam00892 271848011115 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 271848011116 EamA-like transporter family; Region: EamA; pfam00892 271848011117 major facilitator superfamily transporter; Provisional; Region: PRK05122 271848011118 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848011119 putative substrate translocation pore; other site 271848011120 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 271848011121 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 271848011122 catalytic loop [active] 271848011123 iron binding site [ion binding]; other site 271848011124 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 271848011125 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 271848011126 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 271848011127 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 271848011128 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 271848011129 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 271848011130 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 271848011131 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 271848011132 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 271848011133 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 271848011134 N-terminal plug; other site 271848011135 ligand-binding site [chemical binding]; other site 271848011136 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 271848011137 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 271848011138 Walker A/P-loop; other site 271848011139 ATP binding site [chemical binding]; other site 271848011140 Q-loop/lid; other site 271848011141 ABC transporter signature motif; other site 271848011142 Walker B; other site 271848011143 D-loop; other site 271848011144 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 271848011145 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 271848011146 putative ligand binding residues [chemical binding]; other site 271848011147 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 271848011148 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 271848011149 ABC-ATPase subunit interface; other site 271848011150 dimer interface [polypeptide binding]; other site 271848011151 putative PBP binding regions; other site 271848011152 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848011153 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848011154 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848011155 dimerization interface [polypeptide binding]; other site 271848011156 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 271848011157 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 271848011158 putative catalytic residue [active] 271848011159 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 271848011160 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 271848011161 BON domain; Region: BON; pfam04972 271848011162 3HB-oligomer hydrolase (3HBOH); Region: 3HBOH; pfam10605 271848011163 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 271848011164 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 271848011165 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 271848011166 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 271848011167 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 271848011168 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848011169 putative substrate translocation pore; other site 271848011170 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 271848011171 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 271848011172 putative active site [active] 271848011173 catalytic site [active] 271848011174 putative metal binding site [ion binding]; other site 271848011175 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 271848011176 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 271848011177 Coenzyme A binding pocket [chemical binding]; other site 271848011178 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 271848011179 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 271848011180 non-specific DNA binding site [nucleotide binding]; other site 271848011181 salt bridge; other site 271848011182 sequence-specific DNA binding site [nucleotide binding]; other site 271848011183 Cupin domain; Region: Cupin_2; cl17218 271848011184 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 271848011185 Predicted transcriptional regulators [Transcription]; Region: COG1733 271848011186 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 271848011187 dimerization interface [polypeptide binding]; other site 271848011188 putative DNA binding site [nucleotide binding]; other site 271848011189 putative Zn2+ binding site [ion binding]; other site 271848011190 Protein of unknown function (DUF2957); Region: DUF2957; pfam11170 271848011191 Protein of unknown function (DUF2957); Region: DUF2957; pfam11170 271848011192 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 271848011193 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 271848011194 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 271848011195 putative NAD(P) binding site [chemical binding]; other site 271848011196 Predicted transcriptional regulators [Transcription]; Region: COG1733 271848011197 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 271848011198 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 271848011199 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 271848011200 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 271848011201 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 271848011202 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 271848011203 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 271848011204 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 271848011205 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 271848011206 Transposase; Region: HTH_Tnp_1; pfam01527 271848011207 WYL domain; Region: WYL; pfam13280 271848011208 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 271848011209 Part of AAA domain; Region: AAA_19; pfam13245 271848011210 Family description; Region: UvrD_C_2; pfam13538 271848011211 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 271848011212 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 271848011213 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 271848011214 motif II; other site 271848011215 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 271848011216 Transposase; Region: HTH_Tnp_1; pfam01527 271848011217 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 271848011218 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 271848011219 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 271848011220 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 271848011221 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 271848011222 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 271848011223 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 271848011224 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 271848011225 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 271848011226 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 271848011227 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 271848011228 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 271848011229 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 271848011230 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 271848011231 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 271848011232 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 271848011233 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 271848011234 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 271848011235 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 271848011236 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 271848011237 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 271848011238 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 271848011239 Transposase; Region: HTH_Tnp_1; pfam01527 271848011240 IS2 transposase TnpB; Reviewed; Region: PRK09409 271848011241 HTH-like domain; Region: HTH_21; pfam13276 271848011242 Integrase core domain; Region: rve; pfam00665 271848011243 Integrase core domain; Region: rve_3; pfam13683 271848011244 Transposase; Region: HTH_Tnp_1; cl17663 271848011245 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 271848011246 Protein of unknown function (DUF1426); Region: DUF1426; pfam07234 271848011247 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 271848011248 oligomerisation interface [polypeptide binding]; other site 271848011249 mobile loop; other site 271848011250 roof hairpin; other site 271848011251 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 271848011252 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 271848011253 ring oligomerisation interface [polypeptide binding]; other site 271848011254 ATP/Mg binding site [chemical binding]; other site 271848011255 stacking interactions; other site 271848011256 hinge regions; other site 271848011257 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 271848011258 dimer interface [polypeptide binding]; other site 271848011259 substrate binding site [chemical binding]; other site 271848011260 ATP binding site [chemical binding]; other site 271848011261 Rubredoxin [Energy production and conversion]; Region: COG1773 271848011262 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 271848011263 iron binding site [ion binding]; other site 271848011264 hypothetical protein; Validated; Region: PRK00228 271848011265 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 271848011266 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 271848011267 active site 271848011268 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 271848011269 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 271848011270 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 271848011271 dihydroorotase; Provisional; Region: PRK07627 271848011272 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 271848011273 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 271848011274 active site 271848011275 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 271848011276 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 271848011277 putative acyl-acceptor binding pocket; other site 271848011278 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 271848011279 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 271848011280 active site 271848011281 metal binding site [ion binding]; metal-binding site 271848011282 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 271848011283 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 271848011284 NAD binding site [chemical binding]; other site 271848011285 substrate binding site [chemical binding]; other site 271848011286 homodimer interface [polypeptide binding]; other site 271848011287 active site 271848011288 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 271848011289 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 271848011290 substrate binding site; other site 271848011291 tetramer interface; other site 271848011292 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: rmlC; TIGR01221 271848011293 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 271848011294 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 271848011295 NADP binding site [chemical binding]; other site 271848011296 active site 271848011297 putative substrate binding site [chemical binding]; other site 271848011298 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 271848011299 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 271848011300 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 271848011301 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 271848011302 Walker A/P-loop; other site 271848011303 ATP binding site [chemical binding]; other site 271848011304 Q-loop/lid; other site 271848011305 ABC transporter signature motif; other site 271848011306 Walker B; other site 271848011307 D-loop; other site 271848011308 H-loop/switch region; other site 271848011309 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 271848011310 putative carbohydrate binding site [chemical binding]; other site 271848011311 Acyltransferase family; Region: Acyl_transf_3; pfam01757 271848011312 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 271848011313 extended (e) SDRs; Region: SDR_e; cd08946 271848011314 NAD(P) binding site [chemical binding]; other site 271848011315 active site 271848011316 substrate binding site [chemical binding]; other site 271848011317 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 271848011318 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 271848011319 Probable Catalytic site; other site 271848011320 metal-binding site 271848011321 Methyltransferase domain; Region: Methyltransf_23; pfam13489 271848011322 Methyltransferase domain; Region: Methyltransf_12; pfam08242 271848011323 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 271848011324 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 271848011325 active site 271848011326 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 271848011327 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 271848011328 Probable Catalytic site; other site 271848011329 metal-binding site 271848011330 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 271848011331 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 271848011332 active site 271848011333 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 271848011334 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 271848011335 active site 271848011336 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 271848011337 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 271848011338 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 271848011339 putative NAD(P) binding site [chemical binding]; other site 271848011340 active site 271848011341 putative substrate binding site [chemical binding]; other site 271848011342 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 271848011343 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 271848011344 Mg++ binding site [ion binding]; other site 271848011345 putative catalytic motif [active] 271848011346 putative substrate binding site [chemical binding]; other site 271848011347 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 271848011348 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 271848011349 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 271848011350 NAD(P) binding site [chemical binding]; other site 271848011351 homodimer interface [polypeptide binding]; other site 271848011352 substrate binding site [chemical binding]; other site 271848011353 active site 271848011354 This subfamily is composed of uncharacterized bacterial glycosyltransferases in the MraY-like family. This family contains both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases, which...; Region: GT_MraY_like; cd06912 271848011355 Mg++ binding site [ion binding]; other site 271848011356 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 271848011357 putative catalytic motif [active] 271848011358 UDP-glucose 4-epimerase; Region: PLN02240 271848011359 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 271848011360 NAD binding site [chemical binding]; other site 271848011361 homodimer interface [polypeptide binding]; other site 271848011362 active site 271848011363 substrate binding site [chemical binding]; other site 271848011364 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 271848011365 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 271848011366 putative ADP-binding pocket [chemical binding]; other site 271848011367 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 271848011368 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 271848011369 active site 271848011370 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 271848011371 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 271848011372 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 271848011373 active site 271848011374 substrate binding site [chemical binding]; other site 271848011375 metal binding site [ion binding]; metal-binding site 271848011376 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 271848011377 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 271848011378 putative active site [active] 271848011379 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase; Region: Kdo_hydroxy; pfam11004 271848011380 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 271848011381 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 271848011382 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 271848011383 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 271848011384 UreF; Region: UreF; pfam01730 271848011385 urease accessory protein UreE; Provisional; Region: ureE; PRK13263 271848011386 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 271848011387 dimer interface [polypeptide binding]; other site 271848011388 catalytic residues [active] 271848011389 urease subunit alpha; Reviewed; Region: ureC; PRK13207 271848011390 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 271848011391 subunit interactions [polypeptide binding]; other site 271848011392 active site 271848011393 flap region; other site 271848011394 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 271848011395 gamma-beta subunit interface [polypeptide binding]; other site 271848011396 alpha-beta subunit interface [polypeptide binding]; other site 271848011397 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 271848011398 alpha-gamma subunit interface [polypeptide binding]; other site 271848011399 beta-gamma subunit interface [polypeptide binding]; other site 271848011400 UreD urease accessory protein; Region: UreD; cl00530 271848011401 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 271848011402 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 271848011403 Walker A/P-loop; other site 271848011404 ATP binding site [chemical binding]; other site 271848011405 Q-loop/lid; other site 271848011406 ABC transporter signature motif; other site 271848011407 Walker B; other site 271848011408 D-loop; other site 271848011409 H-loop/switch region; other site 271848011410 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 271848011411 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 271848011412 Walker A/P-loop; other site 271848011413 ATP binding site [chemical binding]; other site 271848011414 Q-loop/lid; other site 271848011415 ABC transporter signature motif; other site 271848011416 Walker B; other site 271848011417 D-loop; other site 271848011418 H-loop/switch region; other site 271848011419 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 271848011420 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 271848011421 TM-ABC transporter signature motif; other site 271848011422 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 271848011423 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 271848011424 TM-ABC transporter signature motif; other site 271848011425 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 271848011426 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 271848011427 putative ligand binding site [chemical binding]; other site 271848011428 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 271848011429 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 271848011430 inhibitor-cofactor binding pocket; inhibition site 271848011431 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848011432 catalytic residue [active] 271848011433 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 271848011434 active site residue [active] 271848011435 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 271848011436 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848011437 S-adenosylmethionine binding site [chemical binding]; other site 271848011438 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 271848011439 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 271848011440 FeS/SAM binding site; other site 271848011441 HemN C-terminal domain; Region: HemN_C; pfam06969 271848011442 Flagellin N-methylase; Region: FliB; cl00497 271848011443 Protein of unknown function (DUF1439); Region: DUF1439; cl06345 271848011444 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 271848011445 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848011446 S-adenosylmethionine binding site [chemical binding]; other site 271848011447 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 271848011448 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 271848011449 NADP binding site [chemical binding]; other site 271848011450 dimer interface [polypeptide binding]; other site 271848011451 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848011452 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848011453 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 271848011454 dimerization interface [polypeptide binding]; other site 271848011455 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 271848011456 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 271848011457 active site 271848011458 catalytic triad [active] 271848011459 calcium binding site [ion binding]; other site 271848011460 chromosome condensation membrane protein; Provisional; Region: PRK14196 271848011461 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 271848011462 YGGT family; Region: YGGT; pfam02325 271848011463 YGGT family; Region: YGGT; pfam02325 271848011464 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 271848011465 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 271848011466 serine racemase; Region: PLN02970 271848011467 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 271848011468 tetramer interface [polypeptide binding]; other site 271848011469 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848011470 catalytic residue [active] 271848011471 LysE type translocator; Region: LysE; cl00565 271848011472 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 271848011473 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 271848011474 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 271848011475 N-acetyl-D-glucosamine binding site [chemical binding]; other site 271848011476 catalytic residue [active] 271848011477 aminotransferase; Validated; Region: PRK07337 271848011478 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 271848011479 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848011480 homodimer interface [polypeptide binding]; other site 271848011481 catalytic residue [active] 271848011482 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 271848011483 putative RNA binding site [nucleotide binding]; other site 271848011484 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 271848011485 homopentamer interface [polypeptide binding]; other site 271848011486 active site 271848011487 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 271848011488 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 271848011489 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 271848011490 dimerization interface [polypeptide binding]; other site 271848011491 active site 271848011492 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 271848011493 nucleotide binding region [chemical binding]; other site 271848011494 ATP-binding site [chemical binding]; other site 271848011495 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 271848011496 ATP binding site [chemical binding]; other site 271848011497 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 271848011498 Transposase; Region: DDE_Tnp_ISL3; pfam01610 271848011499 IS2 transposase TnpB; Reviewed; Region: PRK09409 271848011500 HTH-like domain; Region: HTH_21; pfam13276 271848011501 Integrase core domain; Region: rve; pfam00665 271848011502 Integrase core domain; Region: rve_3; pfam13683 271848011503 Transposase; Region: HTH_Tnp_1; cl17663 271848011504 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 271848011505 Transposase; Region: DDE_Tnp_ISL3; pfam01610 271848011506 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 271848011507 Fic/DOC family; Region: Fic; cl00960 271848011508 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 271848011509 Lumazine binding domain; Region: Lum_binding; pfam00677 271848011510 Lumazine binding domain; Region: Lum_binding; pfam00677 271848011511 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 271848011512 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 271848011513 catalytic motif [active] 271848011514 Zn binding site [ion binding]; other site 271848011515 RibD C-terminal domain; Region: RibD_C; cl17279 271848011516 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 271848011517 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 271848011518 inhibitor-cofactor binding pocket; inhibition site 271848011519 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848011520 catalytic residue [active] 271848011521 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 271848011522 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848011523 putative substrate translocation pore; other site 271848011524 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 271848011525 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 271848011526 Walker A/P-loop; other site 271848011527 ATP binding site [chemical binding]; other site 271848011528 Q-loop/lid; other site 271848011529 ABC transporter signature motif; other site 271848011530 Walker B; other site 271848011531 D-loop; other site 271848011532 H-loop/switch region; other site 271848011533 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 271848011534 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848011535 dimer interface [polypeptide binding]; other site 271848011536 conserved gate region; other site 271848011537 putative PBP binding loops; other site 271848011538 ABC-ATPase subunit interface; other site 271848011539 cystine transporter subunit; Provisional; Region: PRK11260 271848011540 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 271848011541 substrate binding pocket [chemical binding]; other site 271848011542 membrane-bound complex binding site; other site 271848011543 hinge residues; other site 271848011544 bifunctional glucokinase/RpiR family transcriptional regulator; Provisional; Region: PRK14101 271848011545 glucokinase; Provisional; Region: glk; PRK00292 271848011546 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 271848011547 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 271848011548 putative active site [active] 271848011549 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 271848011550 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 271848011551 putative active site [active] 271848011552 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 271848011553 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 271848011554 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 271848011555 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 271848011556 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 271848011557 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848011558 dimer interface [polypeptide binding]; other site 271848011559 conserved gate region; other site 271848011560 putative PBP binding loops; other site 271848011561 ABC-ATPase subunit interface; other site 271848011562 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 271848011563 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848011564 dimer interface [polypeptide binding]; other site 271848011565 conserved gate region; other site 271848011566 putative PBP binding loops; other site 271848011567 ABC-ATPase subunit interface; other site 271848011568 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 271848011569 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 271848011570 Walker A/P-loop; other site 271848011571 ATP binding site [chemical binding]; other site 271848011572 Q-loop/lid; other site 271848011573 ABC transporter signature motif; other site 271848011574 Walker B; other site 271848011575 D-loop; other site 271848011576 H-loop/switch region; other site 271848011577 Predicted membrane protein [Function unknown]; Region: COG2860 271848011578 UPF0126 domain; Region: UPF0126; pfam03458 271848011579 UPF0126 domain; Region: UPF0126; pfam03458 271848011580 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 271848011581 Smr domain; Region: Smr; pfam01713 271848011582 thioredoxin reductase; Provisional; Region: PRK10262 271848011583 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 271848011584 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 271848011585 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 271848011586 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 271848011587 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 271848011588 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 271848011589 recombination factor protein RarA; Reviewed; Region: PRK13342 271848011590 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848011591 Walker A motif; other site 271848011592 ATP binding site [chemical binding]; other site 271848011593 Walker B motif; other site 271848011594 arginine finger; other site 271848011595 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 271848011596 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 271848011597 seryl-tRNA synthetase; Provisional; Region: PRK05431 271848011598 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 271848011599 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 271848011600 dimer interface [polypeptide binding]; other site 271848011601 active site 271848011602 motif 1; other site 271848011603 motif 2; other site 271848011604 motif 3; other site 271848011605 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 271848011606 Coenzyme A binding pocket [chemical binding]; other site 271848011607 septum formation inhibitor; Reviewed; Region: PRK01973 271848011608 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 271848011609 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 271848011610 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 271848011611 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 271848011612 Switch I; other site 271848011613 Switch II; other site 271848011614 cell division topological specificity factor MinE; Provisional; Region: PRK13989 271848011615 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 271848011616 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 271848011617 putative ion selectivity filter; other site 271848011618 putative pore gating glutamate residue; other site 271848011619 putative H+/Cl- coupling transport residue; other site 271848011620 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 271848011621 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 271848011622 putative active site [active] 271848011623 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848011624 metabolite-proton symporter; Region: 2A0106; TIGR00883 271848011625 putative substrate translocation pore; other site 271848011626 Uncharacterized conserved protein [Function unknown]; Region: COG3791 271848011627 coproporphyrinogen III oxidase; Provisional; Region: PRK08898 271848011628 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 271848011629 FeS/SAM binding site; other site 271848011630 HemN C-terminal domain; Region: HemN_C; pfam06969 271848011631 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 271848011632 active site 271848011633 dimerization interface [polypeptide binding]; other site 271848011634 ribonuclease PH; Reviewed; Region: rph; PRK00173 271848011635 Ribonuclease PH; Region: RNase_PH_bact; cd11362 271848011636 hexamer interface [polypeptide binding]; other site 271848011637 active site 271848011638 hypothetical protein; Provisional; Region: PRK11820 271848011639 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 271848011640 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 271848011641 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 271848011642 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 271848011643 catalytic site [active] 271848011644 G-X2-G-X-G-K; other site 271848011645 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 271848011646 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 271848011647 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 271848011648 Zn2+ binding site [ion binding]; other site 271848011649 Mg2+ binding site [ion binding]; other site 271848011650 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 271848011651 synthetase active site [active] 271848011652 NTP binding site [chemical binding]; other site 271848011653 metal binding site [ion binding]; metal-binding site 271848011654 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 271848011655 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 271848011656 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 271848011657 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 271848011658 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 271848011659 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 271848011660 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 271848011661 trimer interface [polypeptide binding]; other site 271848011662 eyelet of channel; other site 271848011663 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 271848011664 DNA-binding site [nucleotide binding]; DNA binding site 271848011665 RNA-binding motif; other site 271848011666 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 271848011667 active site 271848011668 catalytic site [active] 271848011669 substrate binding site [chemical binding]; other site 271848011670 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 271848011671 GIY-YIG motif/motif A; other site 271848011672 active site 271848011673 catalytic site [active] 271848011674 putative DNA binding site [nucleotide binding]; other site 271848011675 metal binding site [ion binding]; metal-binding site 271848011676 chorismate mutase; Provisional; Region: PRK09269 271848011677 Chorismate mutase type II; Region: CM_2; cl00693 271848011678 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 271848011679 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 271848011680 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 271848011681 N-terminal plug; other site 271848011682 ligand-binding site [chemical binding]; other site 271848011683 BNR repeat-like domain; Region: BNR_2; pfam13088 271848011684 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 271848011685 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 271848011686 catalytic residues [active] 271848011687 fructose-1,6-bisphosphatase family protein; Region: PLN02628 271848011688 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 271848011689 AMP binding site [chemical binding]; other site 271848011690 metal binding site [ion binding]; metal-binding site 271848011691 active site 271848011692 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 271848011693 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848011694 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 271848011695 putative dimerization interface [polypeptide binding]; other site 271848011696 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 271848011697 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 271848011698 THF binding site; other site 271848011699 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 271848011700 substrate binding site [chemical binding]; other site 271848011701 THF binding site; other site 271848011702 zinc-binding site [ion binding]; other site 271848011703 aminopeptidase N; Provisional; Region: pepN; PRK14015 271848011704 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 271848011705 active site 271848011706 Zn binding site [ion binding]; other site 271848011707 Predicted membrane protein [Function unknown]; Region: COG2119 271848011708 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 271848011709 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 271848011710 guanine deaminase; Provisional; Region: PRK09228 271848011711 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 271848011712 active site 271848011713 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 271848011714 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 271848011715 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 271848011716 active site 271848011717 purine riboside binding site [chemical binding]; other site 271848011718 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 271848011719 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 271848011720 XdhC Rossmann domain; Region: XdhC_C; pfam13478 271848011721 disulfide bond formation protein B; Provisional; Region: PRK02110 271848011722 amidase; Provisional; Region: PRK07056 271848011723 Amidase; Region: Amidase; cl11426 271848011724 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 271848011725 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 271848011726 catalytic triad [active] 271848011727 citrate-proton symporter; Provisional; Region: PRK15075 271848011728 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848011729 putative substrate translocation pore; other site 271848011730 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 271848011731 TPR motif; other site 271848011732 binding surface 271848011733 TPR repeat; Region: TPR_11; pfam13414 271848011734 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 271848011735 binding surface 271848011736 TPR motif; other site 271848011737 TPR repeat; Region: TPR_11; pfam13414 271848011738 Tetratricopeptide repeat; Region: TPR_12; pfam13424 271848011739 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 271848011740 binding surface 271848011741 TPR motif; other site 271848011742 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 271848011743 hypothetical protein; Provisional; Region: PRK06184 271848011744 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 271848011745 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 271848011746 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 271848011747 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 271848011748 catalytic loop [active] 271848011749 iron binding site [ion binding]; other site 271848011750 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929 271848011751 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 271848011752 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 271848011753 [4Fe-4S] binding site [ion binding]; other site 271848011754 molybdopterin cofactor binding site; other site 271848011755 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 271848011756 molybdopterin cofactor binding site; other site 271848011757 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 271848011758 putative dimer interface [polypeptide binding]; other site 271848011759 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 271848011760 SLBB domain; Region: SLBB; pfam10531 271848011761 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 271848011762 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081 271848011763 putative dimer interface [polypeptide binding]; other site 271848011764 [2Fe-2S] cluster binding site [ion binding]; other site 271848011765 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 271848011766 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 271848011767 PBP superfamily domain; Region: PBP_like; pfam12727 271848011768 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848011769 S-adenosylmethionine binding site [chemical binding]; other site 271848011770 phosphoglycolate phosphatase; Provisional; Region: PRK13222 271848011771 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 271848011772 motif II; other site 271848011773 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 271848011774 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 271848011775 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848011776 S-adenosylmethionine binding site [chemical binding]; other site 271848011777 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 271848011778 ligand binding site [chemical binding]; other site 271848011779 DNA gyrase subunit A; Validated; Region: PRK05560 271848011780 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 271848011781 CAP-like domain; other site 271848011782 active site 271848011783 primary dimer interface [polypeptide binding]; other site 271848011784 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 271848011785 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 271848011786 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 271848011787 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 271848011788 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 271848011789 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 271848011790 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 271848011791 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 271848011792 homodimer interface [polypeptide binding]; other site 271848011793 substrate-cofactor binding pocket; other site 271848011794 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848011795 catalytic residue [active] 271848011796 Chorismate mutase type II; Region: CM_2; smart00830 271848011797 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 271848011798 Prephenate dehydratase; Region: PDT; pfam00800 271848011799 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 271848011800 putative L-Phe binding site [chemical binding]; other site 271848011801 bifunctional prephenate dehydrogenase/3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK11861 271848011802 prephenate dehydrogenase; Validated; Region: PRK08507 271848011803 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 271848011804 hinge; other site 271848011805 active site 271848011806 cytidylate kinase; Provisional; Region: cmk; PRK00023 271848011807 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 271848011808 CMP-binding site; other site 271848011809 The sites determining sugar specificity; other site 271848011810 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 271848011811 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 271848011812 RNA binding site [nucleotide binding]; other site 271848011813 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 271848011814 RNA binding site [nucleotide binding]; other site 271848011815 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 271848011816 RNA binding site [nucleotide binding]; other site 271848011817 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 271848011818 RNA binding site [nucleotide binding]; other site 271848011819 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 271848011820 RNA binding site [nucleotide binding]; other site 271848011821 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 271848011822 RNA binding site [nucleotide binding]; other site 271848011823 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 271848011824 IHF dimer interface [polypeptide binding]; other site 271848011825 IHF - DNA interface [nucleotide binding]; other site 271848011826 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 271848011827 tetratricopeptide repeat protein; Provisional; Region: PRK11788 271848011828 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 271848011829 binding surface 271848011830 TPR motif; other site 271848011831 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 271848011832 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 271848011833 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 271848011834 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 271848011835 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 271848011836 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 271848011837 putative ribose interaction site [chemical binding]; other site 271848011838 putative ADP binding site [chemical binding]; other site 271848011839 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 271848011840 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 271848011841 NADP binding site [chemical binding]; other site 271848011842 homopentamer interface [polypeptide binding]; other site 271848011843 substrate binding site [chemical binding]; other site 271848011844 active site 271848011845 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 271848011846 cysteine synthase B; Region: cysM; TIGR01138 271848011847 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 271848011848 dimer interface [polypeptide binding]; other site 271848011849 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848011850 catalytic residue [active] 271848011851 Transglycosylase SLT domain; Region: SLT_2; pfam13406 271848011852 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 271848011853 N-acetyl-D-glucosamine binding site [chemical binding]; other site 271848011854 catalytic residue [active] 271848011855 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 271848011856 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 271848011857 putative active site [active] 271848011858 Zn binding site [ion binding]; other site 271848011859 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 271848011860 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 271848011861 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 271848011862 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 271848011863 Walker A/P-loop; other site 271848011864 ATP binding site [chemical binding]; other site 271848011865 Q-loop/lid; other site 271848011866 ABC transporter signature motif; other site 271848011867 Walker B; other site 271848011868 D-loop; other site 271848011869 H-loop/switch region; other site 271848011870 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 271848011871 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848011872 dimer interface [polypeptide binding]; other site 271848011873 conserved gate region; other site 271848011874 ABC-ATPase subunit interface; other site 271848011875 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 271848011876 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 271848011877 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 271848011878 Ligand binding site [chemical binding]; other site 271848011879 Electron transfer flavoprotein domain; Region: ETF; pfam01012 271848011880 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 271848011881 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 271848011882 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 271848011883 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 271848011884 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 271848011885 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 271848011886 active site 271848011887 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 271848011888 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 271848011889 hydroxyglutarate oxidase; Provisional; Region: PRK11728 271848011890 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 271848011891 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 271848011892 AsnC family; Region: AsnC_trans_reg; pfam01037 271848011893 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 271848011894 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 271848011895 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 271848011896 16S rRNA processing protein RimM; Region: 16S_RimM; TIGR02273 271848011897 RimM N-terminal domain; Region: RimM; pfam01782 271848011898 PRC-barrel domain; Region: PRC; pfam05239 271848011899 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 271848011900 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 271848011901 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 271848011902 putative active site [active] 271848011903 putative CoA binding site [chemical binding]; other site 271848011904 nudix motif; other site 271848011905 metal binding site [ion binding]; metal-binding site 271848011906 CobD/CbiB family protein; Provisional; Region: PRK07630 271848011907 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 271848011908 GTPase RsgA; Reviewed; Region: PRK00098 271848011909 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 271848011910 RNA binding site [nucleotide binding]; other site 271848011911 homodimer interface [polypeptide binding]; other site 271848011912 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 271848011913 GTPase/Zn-binding domain interface [polypeptide binding]; other site 271848011914 GTP/Mg2+ binding site [chemical binding]; other site 271848011915 G4 box; other site 271848011916 G5 box; other site 271848011917 G1 box; other site 271848011918 Switch I region; other site 271848011919 G2 box; other site 271848011920 G3 box; other site 271848011921 Switch II region; other site 271848011922 Peptidase family M48; Region: Peptidase_M48; pfam01435 271848011923 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 271848011924 catalytic site [active] 271848011925 putative active site [active] 271848011926 putative substrate binding site [chemical binding]; other site 271848011927 dimer interface [polypeptide binding]; other site 271848011928 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 271848011929 MPT binding site; other site 271848011930 trimer interface [polypeptide binding]; other site 271848011931 hypothetical protein; Provisional; Region: PRK05255 271848011932 peptidase PmbA; Provisional; Region: PRK11040 271848011933 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 271848011934 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 271848011935 folate binding site [chemical binding]; other site 271848011936 NADP+ binding site [chemical binding]; other site 271848011937 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 271848011938 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848011939 Walker A motif; other site 271848011940 ATP binding site [chemical binding]; other site 271848011941 Walker B motif; other site 271848011942 arginine finger; other site 271848011943 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 271848011944 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848011945 Walker A motif; other site 271848011946 ATP binding site [chemical binding]; other site 271848011947 Walker B motif; other site 271848011948 arginine finger; other site 271848011949 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 271848011950 thymidylate synthase; Provisional; Region: thyA; PRK13821 271848011951 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 271848011952 dimerization interface [polypeptide binding]; other site 271848011953 active site 271848011954 FecR protein; Region: FecR; pfam04773 271848011955 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 271848011956 dimerization interface [polypeptide binding]; other site 271848011957 putative DNA binding site [nucleotide binding]; other site 271848011958 putative Zn2+ binding site [ion binding]; other site 271848011959 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 271848011960 fumarate hydratase; Reviewed; Region: fumC; PRK00485 271848011961 Class II fumarases; Region: Fumarase_classII; cd01362 271848011962 active site 271848011963 tetramer interface [polypeptide binding]; other site 271848011964 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 271848011965 putative efflux protein, MATE family; Region: matE; TIGR00797 271848011966 cation binding site [ion binding]; other site 271848011967 S4 domain; Region: S4_2; pfam13275 271848011968 Protein of unknown function (DUF4088); Region: DUF4088; pfam13317 271848011969 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 271848011970 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 271848011971 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 271848011972 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 271848011973 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848011974 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 271848011975 CreA protein; Region: CreA; pfam05981 271848011976 Ferredoxin [Energy production and conversion]; Region: COG1146 271848011977 4Fe-4S binding domain; Region: Fer4; cl02805 271848011978 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 271848011979 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 271848011980 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 271848011981 active site 271848011982 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 271848011983 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 271848011984 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 271848011985 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 271848011986 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 271848011987 dimerization interface [polypeptide binding]; other site 271848011988 ligand binding site [chemical binding]; other site 271848011989 NADP binding site [chemical binding]; other site 271848011990 catalytic site [active] 271848011991 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 271848011992 RmuC family; Region: RmuC; pfam02646 271848011993 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 271848011994 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 271848011995 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 271848011996 dimer interface [polypeptide binding]; other site 271848011997 putative functional site; other site 271848011998 putative MPT binding site; other site 271848011999 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 271848012000 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 271848012001 GTP binding site; other site 271848012002 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 271848012003 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 271848012004 FeS/SAM binding site; other site 271848012005 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 271848012006 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 271848012007 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 271848012008 homodimer interface [polypeptide binding]; other site 271848012009 oligonucleotide binding site [chemical binding]; other site 271848012010 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 271848012011 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 271848012012 RNA binding surface [nucleotide binding]; other site 271848012013 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 271848012014 active site 271848012015 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 271848012016 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 271848012017 motif II; other site 271848012018 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 271848012019 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 271848012020 iron-sulfur cluster [ion binding]; other site 271848012021 [2Fe-2S] cluster binding site [ion binding]; other site 271848012022 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 271848012023 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 271848012024 tandem repeat interface [polypeptide binding]; other site 271848012025 oligomer interface [polypeptide binding]; other site 271848012026 active site residues [active] 271848012027 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 271848012028 putative SAM binding site [chemical binding]; other site 271848012029 homodimer interface [polypeptide binding]; other site 271848012030 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 271848012031 active site 271848012032 dimer interface [polypeptide binding]; other site 271848012033 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 271848012034 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 271848012035 putative phosphate acyltransferase; Provisional; Region: PRK05331 271848012036 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 271848012037 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 271848012038 dimer interface [polypeptide binding]; other site 271848012039 active site 271848012040 CoA binding pocket [chemical binding]; other site 271848012041 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 271848012042 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 271848012043 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 271848012044 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 271848012045 NAD(P) binding site [chemical binding]; other site 271848012046 homotetramer interface [polypeptide binding]; other site 271848012047 homodimer interface [polypeptide binding]; other site 271848012048 active site 271848012049 acyl carrier protein; Provisional; Region: acpP; PRK00982 271848012050 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 271848012051 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 271848012052 dimer interface [polypeptide binding]; other site 271848012053 active site 271848012054 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 271848012055 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 271848012056 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 271848012057 DNA binding residues [nucleotide binding] 271848012058 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 271848012059 anti-sigma E factor; Provisional; Region: rseB; PRK09455 271848012060 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 271848012061 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 271848012062 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 271848012063 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 271848012064 protein binding site [polypeptide binding]; other site 271848012065 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 271848012066 protein binding site [polypeptide binding]; other site 271848012067 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 271848012068 GTP-binding protein LepA; Provisional; Region: PRK05433 271848012069 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 271848012070 G1 box; other site 271848012071 putative GEF interaction site [polypeptide binding]; other site 271848012072 GTP/Mg2+ binding site [chemical binding]; other site 271848012073 Switch I region; other site 271848012074 G2 box; other site 271848012075 G3 box; other site 271848012076 Switch II region; other site 271848012077 G4 box; other site 271848012078 G5 box; other site 271848012079 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 271848012080 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 271848012081 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 271848012082 signal peptidase I; Provisional; Region: PRK10861 271848012083 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 271848012084 Catalytic site [active] 271848012085 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 271848012086 ribonuclease III; Provisional; Region: PRK14718 271848012087 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 271848012088 dimerization interface [polypeptide binding]; other site 271848012089 active site 271848012090 metal binding site [ion binding]; metal-binding site 271848012091 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 271848012092 GTPase Era; Reviewed; Region: era; PRK00089 271848012093 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 271848012094 G1 box; other site 271848012095 GTP/Mg2+ binding site [chemical binding]; other site 271848012096 Switch I region; other site 271848012097 G2 box; other site 271848012098 Switch II region; other site 271848012099 G3 box; other site 271848012100 G4 box; other site 271848012101 G5 box; other site 271848012102 KH domain; Region: KH_2; pfam07650 271848012103 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 271848012104 Recombination protein O N terminal; Region: RecO_N; pfam11967 271848012105 Recombination protein O C terminal; Region: RecO_C; pfam02565 271848012106 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 271848012107 active site 271848012108 hydrophilic channel; other site 271848012109 dimerization interface [polypeptide binding]; other site 271848012110 catalytic residues [active] 271848012111 active site lid [active] 271848012112 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 271848012113 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 271848012114 beta-hexosaminidase; Provisional; Region: PRK05337 271848012115 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 271848012116 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848012117 active site 271848012118 phosphorylation site [posttranslational modification] 271848012119 intermolecular recognition site; other site 271848012120 dimerization interface [polypeptide binding]; other site 271848012121 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848012122 Walker A motif; other site 271848012123 ATP binding site [chemical binding]; other site 271848012124 Walker B motif; other site 271848012125 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 271848012126 elongation factor P; Validated; Region: PRK00529 271848012127 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 271848012128 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 271848012129 RNA binding site [nucleotide binding]; other site 271848012130 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 271848012131 RNA binding site [nucleotide binding]; other site 271848012132 Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093 271848012133 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394 271848012134 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 271848012135 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 271848012136 GIY-YIG motif/motif A; other site 271848012137 active site 271848012138 catalytic site [active] 271848012139 putative DNA binding site [nucleotide binding]; other site 271848012140 metal binding site [ion binding]; metal-binding site 271848012141 UvrB/uvrC motif; Region: UVR; pfam02151 271848012142 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 271848012143 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 271848012144 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 271848012145 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 271848012146 Transposase, Mutator family; Region: Transposase_mut; pfam00872 271848012147 MULE transposase domain; Region: MULE; pfam10551 271848012148 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 271848012149 LysR family transcriptional regulator; Provisional; Region: PRK14997 271848012150 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848012151 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 271848012152 putative effector binding pocket; other site 271848012153 putative dimerization interface [polypeptide binding]; other site 271848012154 Pirin-related protein [General function prediction only]; Region: COG1741 271848012155 Pirin; Region: Pirin; pfam02678 271848012156 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 271848012157 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 271848012158 Coenzyme A binding pocket [chemical binding]; other site 271848012159 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 271848012160 Protein of unknown function (DUF461); Region: DUF461; pfam04314 271848012161 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 271848012162 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 271848012163 Cu(I) binding site [ion binding]; other site 271848012164 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 271848012165 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 271848012166 active site 271848012167 motif I; other site 271848012168 motif II; other site 271848012169 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 271848012170 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 271848012171 active site 271848012172 homotetramer interface [polypeptide binding]; other site 271848012173 Transposase; Region: DEDD_Tnp_IS110; pfam01548 271848012174 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 271848012175 Transposase; Region: DEDD_Tnp_IS110; pfam01548 271848012176 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 271848012177 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 271848012178 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 271848012179 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 271848012180 Walker A/P-loop; other site 271848012181 ATP binding site [chemical binding]; other site 271848012182 Q-loop/lid; other site 271848012183 ABC transporter signature motif; other site 271848012184 Walker B; other site 271848012185 D-loop; other site 271848012186 H-loop/switch region; other site 271848012187 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 271848012188 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 271848012189 putative ADP-binding pocket [chemical binding]; other site 271848012190 Predicted membrane protein (DUF2214); Region: DUF2214; pfam09980 271848012191 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 271848012192 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 271848012193 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 271848012194 dimerization interface [polypeptide binding]; other site 271848012195 ligand binding site [chemical binding]; other site 271848012196 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 271848012197 Phosphoesterase family; Region: Phosphoesterase; pfam04185 271848012198 Domain of unknown function (DUF756); Region: DUF756; pfam05506 271848012199 Domain of unknown function (DUF756); Region: DUF756; pfam05506 271848012200 pyridoxamine kinase; Validated; Region: PRK05756 271848012201 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 271848012202 dimer interface [polypeptide binding]; other site 271848012203 pyridoxal binding site [chemical binding]; other site 271848012204 ATP binding site [chemical binding]; other site 271848012205 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 271848012206 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 271848012207 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 271848012208 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 271848012209 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 271848012210 hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472 271848012211 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 271848012212 ligand binding site; other site 271848012213 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 271848012214 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 271848012215 B12 binding site [chemical binding]; other site 271848012216 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 271848012217 FeS/SAM binding site; other site 271848012218 hopanoid biosynthesis associated protein HpnK and similar proteins; Region: YdjC_HpnK_like; cd10804 271848012219 putative active site [active] 271848012220 YdjC motif; other site 271848012221 Mg binding site [ion binding]; other site 271848012222 putative homodimer interface [polypeptide binding]; other site 271848012223 putative membrane protein; Region: HpnL; TIGR03476 271848012224 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 271848012225 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 271848012226 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848012227 dimer interface [polypeptide binding]; other site 271848012228 conserved gate region; other site 271848012229 putative PBP binding loops; other site 271848012230 ABC-ATPase subunit interface; other site 271848012231 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 271848012232 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848012233 dimer interface [polypeptide binding]; other site 271848012234 conserved gate region; other site 271848012235 putative PBP binding loops; other site 271848012236 ABC-ATPase subunit interface; other site 271848012237 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 271848012238 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 271848012239 Walker A/P-loop; other site 271848012240 ATP binding site [chemical binding]; other site 271848012241 Q-loop/lid; other site 271848012242 ABC transporter signature motif; other site 271848012243 Walker B; other site 271848012244 D-loop; other site 271848012245 H-loop/switch region; other site 271848012246 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 271848012247 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 271848012248 conserved cys residue [active] 271848012249 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848012250 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848012251 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 271848012252 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 271848012253 inhibitor-cofactor binding pocket; inhibition site 271848012254 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848012255 catalytic residue [active] 271848012256 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 271848012257 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 271848012258 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 271848012259 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 271848012260 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 271848012261 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 271848012262 NAD(P) binding site [chemical binding]; other site 271848012263 catalytic residues [active] 271848012264 succinylarginine dihydrolase; Provisional; Region: PRK13281 271848012265 succinylglutamate desuccinylase; Provisional; Region: PRK05324 271848012266 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 271848012267 active site 271848012268 Zn binding site [ion binding]; other site 271848012269 glutathionine S-transferase; Provisional; Region: PRK10542 271848012270 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 271848012271 C-terminal domain interface [polypeptide binding]; other site 271848012272 GSH binding site (G-site) [chemical binding]; other site 271848012273 dimer interface [polypeptide binding]; other site 271848012274 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 271848012275 dimer interface [polypeptide binding]; other site 271848012276 N-terminal domain interface [polypeptide binding]; other site 271848012277 substrate binding pocket (H-site) [chemical binding]; other site 271848012278 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848012279 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848012280 LysR substrate binding domain; Region: LysR_substrate; pfam03466 271848012281 dimerization interface [polypeptide binding]; other site 271848012282 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 271848012283 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 271848012284 substrate binding pocket [chemical binding]; other site 271848012285 membrane-bound complex binding site; other site 271848012286 hinge residues; other site 271848012287 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 271848012288 Fatty acid desaturase; Region: FA_desaturase; pfam00487 271848012289 putative di-iron ligands [ion binding]; other site 271848012290 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 271848012291 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 271848012292 Subunit I/III interface [polypeptide binding]; other site 271848012293 Subunit III/IV interface [polypeptide binding]; other site 271848012294 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 271848012295 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 271848012296 D-pathway; other site 271848012297 Putative ubiquinol binding site [chemical binding]; other site 271848012298 Low-spin heme (heme b) binding site [chemical binding]; other site 271848012299 Putative water exit pathway; other site 271848012300 Binuclear center (heme o3/CuB) [ion binding]; other site 271848012301 K-pathway; other site 271848012302 Putative proton exit pathway; other site 271848012303 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 271848012304 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 271848012305 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 271848012306 Hemerythrin; Region: Hemerythrin; cd12107 271848012307 Fe binding site [ion binding]; other site 271848012308 Predicted transcriptional regulator [Transcription]; Region: COG1959 271848012309 Transcriptional regulator; Region: Rrf2; cl17282 271848012310 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 271848012311 Domain of unknown function DUF59; Region: DUF59; cl00941 271848012312 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 271848012313 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 271848012314 trimerization site [polypeptide binding]; other site 271848012315 active site 271848012316 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 271848012317 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 271848012318 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 271848012319 catalytic residue [active] 271848012320 FeS assembly protein SufD; Region: sufD; TIGR01981 271848012321 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 271848012322 FeS assembly ATPase SufC; Region: sufC; TIGR01978 271848012323 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 271848012324 Walker A/P-loop; other site 271848012325 ATP binding site [chemical binding]; other site 271848012326 Q-loop/lid; other site 271848012327 ABC transporter signature motif; other site 271848012328 Walker B; other site 271848012329 D-loop; other site 271848012330 H-loop/switch region; other site 271848012331 putative ABC transporter; Region: ycf24; CHL00085 271848012332 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 271848012333 NnrS protein; Region: NnrS; pfam05940 271848012334 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 271848012335 dimerization interface [polypeptide binding]; other site 271848012336 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 271848012337 dimer interface [polypeptide binding]; other site 271848012338 putative CheW interface [polypeptide binding]; other site 271848012339 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 271848012340 HemN C-terminal domain; Region: HemN_C; pfam06969 271848012341 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 271848012342 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 271848012343 ligand binding site [chemical binding]; other site 271848012344 flexible hinge region; other site 271848012345 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 271848012346 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 271848012347 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 271848012348 FMN binding site [chemical binding]; other site 271848012349 substrate binding site [chemical binding]; other site 271848012350 putative catalytic residue [active] 271848012351 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 271848012352 Peptidase family U32; Region: Peptidase_U32; pfam01136 271848012353 putative protease; Provisional; Region: PRK15447 271848012354 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 271848012355 SCP-2 sterol transfer family; Region: SCP2; cl01225 271848012356 DGC domain; Region: DGC; pfam08859 271848012357 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 271848012358 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 271848012359 FeS/SAM binding site; other site 271848012360 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 271848012361 Class III ribonucleotide reductase; Region: RNR_III; cd01675 271848012362 effector binding site; other site 271848012363 active site 271848012364 Zn binding site [ion binding]; other site 271848012365 NnrS protein; Region: NnrS; pfam05940 271848012366 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 271848012367 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 271848012368 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 271848012369 Fatty acid desaturase; Region: FA_desaturase; pfam00487 271848012370 Di-iron ligands [ion binding]; other site 271848012371 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 271848012372 DNA photolyase; Region: DNA_photolyase; pfam00875 271848012373 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 271848012374 ligand-binding site [chemical binding]; other site 271848012375 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 271848012376 Autoinducer binding domain; Region: Autoind_bind; pfam03472 271848012377 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 271848012378 DNA binding residues [nucleotide binding] 271848012379 dimerization interface [polypeptide binding]; other site 271848012380 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 271848012381 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 271848012382 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 271848012383 active sites [active] 271848012384 tetramer interface [polypeptide binding]; other site 271848012385 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 271848012386 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 271848012387 DNA-binding site [nucleotide binding]; DNA binding site 271848012388 UTRA domain; Region: UTRA; pfam07702 271848012389 urocanate hydratase; Provisional; Region: PRK05414 271848012390 HutD; Region: HutD; pfam05962 271848012391 imidazolonepropionase; Validated; Region: PRK09356 271848012392 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 271848012393 active site 271848012394 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 271848012395 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 271848012396 active site 271848012397 N-formylglutamate amidohydrolase; Region: FGase; cl01522 271848012398 Peptidase C26; Region: Peptidase_C26; pfam07722 271848012399 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 271848012400 catalytic triad [active] 271848012401 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 271848012402 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 271848012403 putative aminotransferase; Validated; Region: PRK07480 271848012404 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 271848012405 inhibitor-cofactor binding pocket; inhibition site 271848012406 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848012407 catalytic residue [active] 271848012408 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 271848012409 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848012410 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848012411 dimerization interface [polypeptide binding]; other site 271848012412 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 271848012413 active site 271848012414 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 271848012415 CoA-transferase family III; Region: CoA_transf_3; pfam02515 271848012416 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848012417 metabolite-proton symporter; Region: 2A0106; TIGR00883 271848012418 putative substrate translocation pore; other site 271848012419 oxidative damage protection protein; Provisional; Region: PRK05408 271848012420 N-acetylglutamate synthase; Validated; Region: PRK05279 271848012421 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 271848012422 putative feedback inhibition sensing region; other site 271848012423 putative nucleotide binding site [chemical binding]; other site 271848012424 putative substrate binding site [chemical binding]; other site 271848012425 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 271848012426 Coenzyme A binding pocket [chemical binding]; other site 271848012427 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 271848012428 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 271848012429 ATP binding site [chemical binding]; other site 271848012430 putative Mg++ binding site [ion binding]; other site 271848012431 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 271848012432 nucleotide binding region [chemical binding]; other site 271848012433 ATP-binding site [chemical binding]; other site 271848012434 Helicase associated domain (HA2); Region: HA2; pfam04408 271848012435 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 271848012436 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 271848012437 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 271848012438 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 271848012439 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 271848012440 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 271848012441 Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264 271848012442 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 271848012443 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 271848012444 putative MPT binding site; other site 271848012445 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 271848012446 active site residue [active] 271848012447 glutamine synthetase; Provisional; Region: glnA; PRK09469 271848012448 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 271848012449 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 271848012450 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 271848012451 PAS domain; Region: PAS; smart00091 271848012452 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271848012453 dimer interface [polypeptide binding]; other site 271848012454 phosphorylation site [posttranslational modification] 271848012455 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848012456 ATP binding site [chemical binding]; other site 271848012457 Mg2+ binding site [ion binding]; other site 271848012458 G-X-G motif; other site 271848012459 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 271848012460 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848012461 active site 271848012462 phosphorylation site [posttranslational modification] 271848012463 intermolecular recognition site; other site 271848012464 dimerization interface [polypeptide binding]; other site 271848012465 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848012466 Walker A motif; other site 271848012467 ATP binding site [chemical binding]; other site 271848012468 Walker B motif; other site 271848012469 arginine finger; other site 271848012470 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 271848012471 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 271848012472 putative catalytic site [active] 271848012473 putative phosphate binding site [ion binding]; other site 271848012474 active site 271848012475 metal binding site A [ion binding]; metal-binding site 271848012476 DNA binding site [nucleotide binding] 271848012477 putative AP binding site [nucleotide binding]; other site 271848012478 putative metal binding site B [ion binding]; other site 271848012479 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 271848012480 transcriptional regulator NarL; Provisional; Region: PRK10651 271848012481 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848012482 active site 271848012483 phosphorylation site [posttranslational modification] 271848012484 intermolecular recognition site; other site 271848012485 dimerization interface [polypeptide binding]; other site 271848012486 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 271848012487 DNA binding residues [nucleotide binding] 271848012488 dimerization interface [polypeptide binding]; other site 271848012489 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 271848012490 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 271848012491 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 271848012492 dimerization interface [polypeptide binding]; other site 271848012493 GAF domain; Region: GAF_3; pfam13492 271848012494 Histidine kinase; Region: HisKA_3; pfam07730 271848012495 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848012496 ATP binding site [chemical binding]; other site 271848012497 Mg2+ binding site [ion binding]; other site 271848012498 G-X-G motif; other site 271848012499 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 271848012500 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 271848012501 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 271848012502 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 271848012503 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 271848012504 [4Fe-4S] binding site [ion binding]; other site 271848012505 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 271848012506 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 271848012507 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 271848012508 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 271848012509 molybdopterin cofactor binding site; other site 271848012510 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 271848012511 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848012512 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 271848012513 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848012514 putative substrate translocation pore; other site 271848012515 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 271848012516 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 271848012517 active site 271848012518 catalytic triad [active] 271848012519 oxyanion hole [active] 271848012520 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 271848012521 active site 271848012522 DNA polymerase IV; Validated; Region: PRK02406 271848012523 DNA binding site [nucleotide binding] 271848012524 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 271848012525 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 271848012526 active site 271848012527 Zn binding site [ion binding]; other site 271848012528 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14189 271848012529 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 271848012530 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 271848012531 homodimer interface [polypeptide binding]; other site 271848012532 NADP binding site [chemical binding]; other site 271848012533 substrate binding site [chemical binding]; other site 271848012534 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 271848012535 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848012536 active site 271848012537 phosphorylation site [posttranslational modification] 271848012538 intermolecular recognition site; other site 271848012539 dimerization interface [polypeptide binding]; other site 271848012540 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 271848012541 DNA binding residues [nucleotide binding] 271848012542 dimerization interface [polypeptide binding]; other site 271848012543 CHASE domain; Region: CHASE; cl01369 271848012544 PAS domain S-box; Region: sensory_box; TIGR00229 271848012545 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271848012546 putative active site [active] 271848012547 heme pocket [chemical binding]; other site 271848012548 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271848012549 dimer interface [polypeptide binding]; other site 271848012550 phosphorylation site [posttranslational modification] 271848012551 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848012552 ATP binding site [chemical binding]; other site 271848012553 Mg2+ binding site [ion binding]; other site 271848012554 G-X-G motif; other site 271848012555 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 271848012556 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 271848012557 dimer interface [polypeptide binding]; other site 271848012558 TPP-binding site [chemical binding]; other site 271848012559 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 271848012560 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 271848012561 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 271848012562 E3 interaction surface; other site 271848012563 lipoyl attachment site [posttranslational modification]; other site 271848012564 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 271848012565 E3 interaction surface; other site 271848012566 lipoyl attachment site [posttranslational modification]; other site 271848012567 e3 binding domain; Region: E3_binding; pfam02817 271848012568 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 271848012569 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 271848012570 E3 interaction surface; other site 271848012571 lipoyl attachment site [posttranslational modification]; other site 271848012572 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 271848012573 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 271848012574 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 271848012575 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 271848012576 Phasin protein; Region: Phasin_2; pfam09361 271848012577 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 271848012578 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 271848012579 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 271848012580 Transcriptional regulator [Transcription]; Region: IclR; COG1414 271848012581 Bacterial transcriptional regulator; Region: IclR; pfam01614 271848012582 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 271848012583 Cysteine-rich domain; Region: CCG; pfam02754 271848012584 Cysteine-rich domain; Region: CCG; pfam02754 271848012585 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 271848012586 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 271848012587 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 271848012588 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 271848012589 Low molecular weight phosphatase family; Region: LMWPc; cd00115 271848012590 active site 271848012591 Predicted transcriptional regulator [Transcription]; Region: COG1959 271848012592 iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010 271848012593 cysteine desulfurase; Provisional; Region: PRK14012 271848012594 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 271848012595 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 271848012596 catalytic residue [active] 271848012597 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 271848012598 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 271848012599 trimerization site [polypeptide binding]; other site 271848012600 active site 271848012601 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 271848012602 co-chaperone HscB; Provisional; Region: hscB; PRK03578 271848012603 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 271848012604 HSP70 interaction site [polypeptide binding]; other site 271848012605 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 271848012606 chaperone protein HscA; Provisional; Region: hscA; PRK05183 271848012607 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 271848012608 nucleotide binding site [chemical binding]; other site 271848012609 putative NEF/HSP70 interaction site [polypeptide binding]; other site 271848012610 SBD interface [polypeptide binding]; other site 271848012611 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 271848012612 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 271848012613 catalytic loop [active] 271848012614 iron binding site [ion binding]; other site 271848012615 Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384 271848012616 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 271848012617 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 271848012618 dimer interface [polypeptide binding]; other site 271848012619 putative anticodon binding site; other site 271848012620 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 271848012621 motif 1; other site 271848012622 active site 271848012623 motif 2; other site 271848012624 motif 3; other site 271848012625 peptide chain release factor 2; Validated; Region: prfB; PRK00578 271848012626 This domain is found in peptide chain release factors; Region: PCRF; smart00937 271848012627 RF-1 domain; Region: RF-1; pfam00472 271848012628 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 271848012629 DHH family; Region: DHH; pfam01368 271848012630 DHHA1 domain; Region: DHHA1; pfam02272 271848012631 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4255 271848012632 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 271848012633 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 271848012634 FtsX-like permease family; Region: FtsX; pfam02687 271848012635 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 271848012636 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 271848012637 Walker A/P-loop; other site 271848012638 ATP binding site [chemical binding]; other site 271848012639 Q-loop/lid; other site 271848012640 ABC transporter signature motif; other site 271848012641 Walker B; other site 271848012642 D-loop; other site 271848012643 H-loop/switch region; other site 271848012644 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 271848012645 active site 271848012646 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 271848012647 Competence protein; Region: Competence; pfam03772 271848012648 Competence protein; Region: Competence; pfam03772 271848012649 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 271848012650 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 271848012651 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 271848012652 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 271848012653 nucleophilic elbow; other site 271848012654 catalytic triad; other site 271848012655 CTP synthetase; Validated; Region: pyrG; PRK05380 271848012656 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 271848012657 Catalytic site [active] 271848012658 active site 271848012659 UTP binding site [chemical binding]; other site 271848012660 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 271848012661 active site 271848012662 putative oxyanion hole; other site 271848012663 catalytic triad [active] 271848012664 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 271848012665 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 271848012666 enolase; Provisional; Region: eno; PRK00077 271848012667 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 271848012668 dimer interface [polypeptide binding]; other site 271848012669 metal binding site [ion binding]; metal-binding site 271848012670 substrate binding pocket [chemical binding]; other site 271848012671 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 271848012672 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 271848012673 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 271848012674 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 271848012675 dimerization interface [polypeptide binding]; other site 271848012676 domain crossover interface; other site 271848012677 redox-dependent activation switch; other site 271848012678 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 271848012679 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 271848012680 trimer interface [polypeptide binding]; other site 271848012681 putative metal binding site [ion binding]; other site 271848012682 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 271848012683 dinuclear metal binding motif [ion binding]; other site 271848012684 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 271848012685 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 271848012686 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 271848012687 catalytic site [active] 271848012688 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 271848012689 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 271848012690 active site 271848012691 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 271848012692 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 271848012693 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 271848012694 Peptidase family M50; Region: Peptidase_M50; pfam02163 271848012695 active site 271848012696 putative substrate binding region [chemical binding]; other site 271848012697 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 271848012698 active site 271848012699 HIGH motif; other site 271848012700 dimer interface [polypeptide binding]; other site 271848012701 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 271848012702 active site 271848012703 KMSKS motif; other site 271848012704 Methyltransferase domain; Region: Methyltransf_18; pfam12847 271848012705 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 271848012706 dihydrodipicolinate synthase; Region: dapA; TIGR00674 271848012707 dimer interface [polypeptide binding]; other site 271848012708 active site 271848012709 catalytic residue [active] 271848012710 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 271848012711 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 271848012712 Uncharacterized conserved protein [Function unknown]; Region: COG2850 271848012713 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 271848012714 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 271848012715 MutS domain I; Region: MutS_I; pfam01624 271848012716 MutS domain II; Region: MutS_II; pfam05188 271848012717 MutS domain III; Region: MutS_III; pfam05192 271848012718 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 271848012719 Walker A/P-loop; other site 271848012720 ATP binding site [chemical binding]; other site 271848012721 Q-loop/lid; other site 271848012722 ABC transporter signature motif; other site 271848012723 Walker B; other site 271848012724 D-loop; other site 271848012725 H-loop/switch region; other site 271848012726 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 271848012727 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 271848012728 active site 271848012729 DNA binding site [nucleotide binding] 271848012730 Int/Topo IB signature motif; other site 271848012731 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 271848012732 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 271848012733 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 271848012734 catalytic residue [active] 271848012735 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 271848012736 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 271848012737 PAAR motif; Region: PAAR_motif; pfam05488 271848012738 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 271848012739 IS2 transposase TnpB; Reviewed; Region: PRK09409 271848012740 HTH-like domain; Region: HTH_21; pfam13276 271848012741 Integrase core domain; Region: rve; pfam00665 271848012742 Integrase core domain; Region: rve_3; pfam13683 271848012743 Transposase; Region: HTH_Tnp_1; cl17663 271848012744 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 271848012745 Protein of unknown function (DUF3620); Region: DUF3620; cl02233 271848012746 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 271848012747 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 271848012748 active site 271848012749 dimerization interface [polypeptide binding]; other site 271848012750 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 271848012751 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 271848012752 serine O-acetyltransferase; Region: cysE; TIGR01172 271848012753 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 271848012754 trimer interface [polypeptide binding]; other site 271848012755 active site 271848012756 substrate binding site [chemical binding]; other site 271848012757 CoA binding site [chemical binding]; other site 271848012758 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 271848012759 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 271848012760 putative active site [active] 271848012761 putative metal binding site [ion binding]; other site 271848012762 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 271848012763 substrate binding site [chemical binding]; other site 271848012764 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 271848012765 substrate binding site [chemical binding]; other site 271848012766 TPR repeat; Region: TPR_11; pfam13414 271848012767 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 271848012768 binding surface 271848012769 TPR motif; other site 271848012770 Tetratricopeptide repeat; Region: TPR_16; pfam13432 271848012771 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 271848012772 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 271848012773 active site 271848012774 HIGH motif; other site 271848012775 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 271848012776 KMSKS motif; other site 271848012777 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 271848012778 tRNA binding surface [nucleotide binding]; other site 271848012779 anticodon binding site; other site 271848012780 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 271848012781 endonuclease III; Region: ENDO3c; smart00478 271848012782 minor groove reading motif; other site 271848012783 helix-hairpin-helix signature motif; other site 271848012784 substrate binding pocket [chemical binding]; other site 271848012785 active site 271848012786 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 271848012787 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 271848012788 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 271848012789 Ligand Binding Site [chemical binding]; other site 271848012790 TilS substrate binding domain; Region: TilS; pfam09179 271848012791 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 271848012792 aspartate kinase; Reviewed; Region: PRK06635 271848012793 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 271848012794 putative nucleotide binding site [chemical binding]; other site 271848012795 putative catalytic residues [active] 271848012796 putative Mg ion binding site [ion binding]; other site 271848012797 putative aspartate binding site [chemical binding]; other site 271848012798 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 271848012799 putative allosteric regulatory site; other site 271848012800 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 271848012801 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 271848012802 active site 271848012803 catalytic triad [active] 271848012804 oxyanion hole [active] 271848012805 Autotransporter beta-domain; Region: Autotransporter; smart00869 271848012806 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 271848012807 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 271848012808 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 271848012809 HlyD family secretion protein; Region: HlyD_3; pfam13437 271848012810 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 271848012811 ligand-binding site [chemical binding]; other site 271848012812 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 271848012813 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 271848012814 acyl-activating enzyme (AAE) consensus motif; other site 271848012815 AMP binding site [chemical binding]; other site 271848012816 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 271848012817 Transmembrane secretion effector; Region: MFS_3; pfam05977 271848012818 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848012819 putative substrate translocation pore; other site 271848012820 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 271848012821 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 271848012822 Condensation domain; Region: Condensation; pfam00668 271848012823 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 271848012824 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 271848012825 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 271848012826 acyl-activating enzyme (AAE) consensus motif; other site 271848012827 AMP binding site [chemical binding]; other site 271848012828 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 271848012829 Condensation domain; Region: Condensation; pfam00668 271848012830 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 271848012831 Condensation domain; Region: Condensation; pfam00668 271848012832 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 271848012833 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 271848012834 acyl-activating enzyme (AAE) consensus motif; other site 271848012835 AMP binding site [chemical binding]; other site 271848012836 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 271848012837 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 271848012838 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 271848012839 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 271848012840 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 271848012841 active site 271848012842 iron coordination sites [ion binding]; other site 271848012843 substrate binding pocket [chemical binding]; other site 271848012844 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848012845 S-adenosylmethionine binding site [chemical binding]; other site 271848012846 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 271848012847 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 271848012848 TPP-binding site [chemical binding]; other site 271848012849 dimer interface [polypeptide binding]; other site 271848012850 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 271848012851 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 271848012852 PYR/PP interface [polypeptide binding]; other site 271848012853 dimer interface [polypeptide binding]; other site 271848012854 TPP binding site [chemical binding]; other site 271848012855 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 271848012856 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 271848012857 phosphoserine aminotransferase; Provisional; Region: PRK12462 271848012858 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 271848012859 catalytic residue [active] 271848012860 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 271848012861 active site 271848012862 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 271848012863 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 271848012864 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 271848012865 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 271848012866 Active Sites [active] 271848012867 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 271848012868 G1 box; other site 271848012869 GTP/Mg2+ binding site [chemical binding]; other site 271848012870 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 271848012871 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 271848012872 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 271848012873 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848012874 catalytic residue [active] 271848012875 dimer interface [polypeptide binding]; other site 271848012876 argininosuccinate lyase; Provisional; Region: PRK02186 271848012877 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 271848012878 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 271848012879 tetramer interface [polypeptide binding]; other site 271848012880 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 271848012881 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 271848012882 active site 271848012883 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 271848012884 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 271848012885 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 271848012886 putative [Fe4-S4] binding site [ion binding]; other site 271848012887 putative molybdopterin cofactor binding site [chemical binding]; other site 271848012888 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 271848012889 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 271848012890 putative molybdopterin cofactor binding site; other site 271848012891 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06997 271848012892 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 271848012893 NAD binding site [chemical binding]; other site 271848012894 homotetramer interface [polypeptide binding]; other site 271848012895 homodimer interface [polypeptide binding]; other site 271848012896 substrate binding site [chemical binding]; other site 271848012897 active site 271848012898 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 271848012899 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 271848012900 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 271848012901 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848012902 dimer interface [polypeptide binding]; other site 271848012903 conserved gate region; other site 271848012904 putative PBP binding loops; other site 271848012905 ABC-ATPase subunit interface; other site 271848012906 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 271848012907 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 271848012908 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848012909 dimer interface [polypeptide binding]; other site 271848012910 conserved gate region; other site 271848012911 putative PBP binding loops; other site 271848012912 ABC-ATPase subunit interface; other site 271848012913 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 271848012914 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 271848012915 Walker A/P-loop; other site 271848012916 ATP binding site [chemical binding]; other site 271848012917 Q-loop/lid; other site 271848012918 ABC transporter signature motif; other site 271848012919 Walker B; other site 271848012920 D-loop; other site 271848012921 H-loop/switch region; other site 271848012922 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 271848012923 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 271848012924 Walker A/P-loop; other site 271848012925 ATP binding site [chemical binding]; other site 271848012926 Q-loop/lid; other site 271848012927 ABC transporter signature motif; other site 271848012928 Walker B; other site 271848012929 D-loop; other site 271848012930 H-loop/switch region; other site 271848012931 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 271848012932 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 271848012933 NlpC/P60 family; Region: NLPC_P60; pfam00877 271848012934 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 271848012935 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 271848012936 active site 271848012937 nucleophile elbow; other site 271848012938 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 271848012939 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 271848012940 active site 271848012941 HIGH motif; other site 271848012942 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 271848012943 active site 271848012944 KMSKS motif; other site 271848012945 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 271848012946 Coenzyme A binding pocket [chemical binding]; other site 271848012947 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 271848012948 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848012949 Helix-turn-helix domain; Region: HTH_18; pfam12833 271848012950 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848012951 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 271848012952 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 271848012953 putative active site pocket [active] 271848012954 dimerization interface [polypeptide binding]; other site 271848012955 putative catalytic residue [active] 271848012956 malate synthase A; Region: malate_syn_A; TIGR01344 271848012957 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 271848012958 active site 271848012959 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 271848012960 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 271848012961 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848012962 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 271848012963 putative effector binding pocket; other site 271848012964 dimerization interface [polypeptide binding]; other site 271848012965 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 271848012966 Ligand Binding Site [chemical binding]; other site 271848012967 isocitrate lyase; Provisional; Region: PRK15063 271848012968 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 271848012969 tetramer interface [polypeptide binding]; other site 271848012970 active site 271848012971 Mg2+/Mn2+ binding site [ion binding]; other site 271848012972 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 271848012973 DEAD-like helicases superfamily; Region: DEXDc; smart00487 271848012974 ATP binding site [chemical binding]; other site 271848012975 Mg++ binding site [ion binding]; other site 271848012976 motif III; other site 271848012977 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 271848012978 nucleotide binding region [chemical binding]; other site 271848012979 ATP-binding site [chemical binding]; other site 271848012980 Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a...; Region: ACBP; cl00221 271848012981 acyl-CoA binding pocket [chemical binding]; other site 271848012982 CoA binding site [chemical binding]; other site 271848012983 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 271848012984 Glycoprotease family; Region: Peptidase_M22; pfam00814 271848012985 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 271848012986 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 271848012987 Coenzyme A binding pocket [chemical binding]; other site 271848012988 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 271848012989 Fe-S cluster binding site [ion binding]; other site 271848012990 active site 271848012991 Domain of unknown function (DUF1853); Region: DUF1853; pfam08907 271848012992 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 271848012993 dimer interface [polypeptide binding]; other site 271848012994 substrate binding site [chemical binding]; other site 271848012995 ATP binding site [chemical binding]; other site 271848012996 lysophospholipid transporter LplT; Provisional; Region: PRK11195 271848012997 alanine racemase; Reviewed; Region: dadX; PRK03646 271848012998 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 271848012999 active site 271848013000 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 271848013001 substrate binding site [chemical binding]; other site 271848013002 catalytic residues [active] 271848013003 dimer interface [polypeptide binding]; other site 271848013004 DNA repair protein RadA; Provisional; Region: PRK11823 271848013005 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 271848013006 Walker A motif/ATP binding site; other site 271848013007 ATP binding site [chemical binding]; other site 271848013008 Walker B motif; other site 271848013009 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 271848013010 Protein of unknown function (DUF2866); Region: DUF2866; pfam11065 271848013011 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 271848013012 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 271848013013 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 271848013014 ABC transporter; Region: ABC_tran_2; pfam12848 271848013015 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 271848013016 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 271848013017 catalytic residues [active] 271848013018 dimer interface [polypeptide binding]; other site 271848013019 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 271848013020 Putative catalytic domain, repeat 1, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_1; cd09155 271848013021 putative active site [active] 271848013022 catalytic site [active] 271848013023 Putative catalytic domain, repeat 2, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_2; cd09161 271848013024 putative active site [active] 271848013025 catalytic site [active] 271848013026 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 271848013027 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848013028 S-adenosylmethionine binding site [chemical binding]; other site 271848013029 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 271848013030 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 271848013031 metal binding site [ion binding]; metal-binding site 271848013032 dimer interface [polypeptide binding]; other site 271848013033 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 271848013034 ArsC family; Region: ArsC; pfam03960 271848013035 putative catalytic residues [active] 271848013036 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 271848013037 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 271848013038 trimer interface [polypeptide binding]; other site 271848013039 active site 271848013040 substrate binding site [chemical binding]; other site 271848013041 CoA binding site [chemical binding]; other site 271848013042 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 271848013043 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 271848013044 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848013045 homodimer interface [polypeptide binding]; other site 271848013046 catalytic residue [active] 271848013047 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 271848013048 EamA-like transporter family; Region: EamA; pfam00892 271848013049 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 271848013050 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 271848013051 Walker A/P-loop; other site 271848013052 ATP binding site [chemical binding]; other site 271848013053 Q-loop/lid; other site 271848013054 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 271848013055 Q-loop/lid; other site 271848013056 ABC transporter signature motif; other site 271848013057 Walker B; other site 271848013058 D-loop; other site 271848013059 H-loop/switch region; other site 271848013060 ZipA, C-terminal domain (FtsZ-binding); Region: ZipA_C; smart00771 271848013061 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 271848013062 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 271848013063 nucleotide binding pocket [chemical binding]; other site 271848013064 K-X-D-G motif; other site 271848013065 catalytic site [active] 271848013066 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 271848013067 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 271848013068 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 271848013069 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 271848013070 Dimer interface [polypeptide binding]; other site 271848013071 BRCT sequence motif; other site 271848013072 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 271848013073 active site 271848013074 catalytic residues [active] 271848013075 metal binding site [ion binding]; metal-binding site 271848013076 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 271848013077 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 271848013078 RNA binding surface [nucleotide binding]; other site 271848013079 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 271848013080 active site 271848013081 PII uridylyl-transferase; Provisional; Region: PRK03059 271848013082 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 271848013083 metal binding triad; other site 271848013084 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 271848013085 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 271848013086 Zn2+ binding site [ion binding]; other site 271848013087 Mg2+ binding site [ion binding]; other site 271848013088 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 271848013089 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 271848013090 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 271848013091 active site 271848013092 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 271848013093 rRNA interaction site [nucleotide binding]; other site 271848013094 S8 interaction site; other site 271848013095 putative laminin-1 binding site; other site 271848013096 elongation factor Ts; Provisional; Region: tsf; PRK09377 271848013097 UBA/TS-N domain; Region: UBA; pfam00627 271848013098 Elongation factor TS; Region: EF_TS; pfam00889 271848013099 Elongation factor TS; Region: EF_TS; pfam00889 271848013100 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 271848013101 putative nucleotide binding site [chemical binding]; other site 271848013102 uridine monophosphate binding site [chemical binding]; other site 271848013103 homohexameric interface [polypeptide binding]; other site 271848013104 ribosome recycling factor; Reviewed; Region: frr; PRK00083 271848013105 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 271848013106 hinge region; other site 271848013107 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 271848013108 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 271848013109 catalytic residue [active] 271848013110 putative FPP diphosphate binding site; other site 271848013111 putative FPP binding hydrophobic cleft; other site 271848013112 dimer interface [polypeptide binding]; other site 271848013113 putative IPP diphosphate binding site; other site 271848013114 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 271848013115 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 271848013116 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 271848013117 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK12464 271848013118 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 271848013119 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 271848013120 zinc metallopeptidase RseP; Provisional; Region: PRK10779 271848013121 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 271848013122 active site 271848013123 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 271848013124 protein binding site [polypeptide binding]; other site 271848013125 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 271848013126 putative substrate binding region [chemical binding]; other site 271848013127 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 271848013128 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 271848013129 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 271848013130 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 271848013131 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 271848013132 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 271848013133 Surface antigen; Region: Bac_surface_Ag; pfam01103 271848013134 periplasmic chaperone; Provisional; Region: PRK10780 271848013135 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 271848013136 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 271848013137 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 271848013138 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 271848013139 trimer interface [polypeptide binding]; other site 271848013140 active site 271848013141 UDP-GlcNAc binding site [chemical binding]; other site 271848013142 lipid binding site [chemical binding]; lipid-binding site 271848013143 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 271848013144 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 271848013145 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 271848013146 active site 271848013147 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 271848013148 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 271848013149 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 271848013150 RNA/DNA hybrid binding site [nucleotide binding]; other site 271848013151 active site 271848013152 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 271848013153 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 271848013154 PEP synthetase regulatory protein; Provisional; Region: PRK05339 271848013155 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 271848013156 peptidase domain interface [polypeptide binding]; other site 271848013157 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 271848013158 active site 271848013159 catalytic triad [active] 271848013160 calcium binding site [ion binding]; other site 271848013161 Phytochelatin synthase; Region: Phytochelatin; pfam05023 271848013162 phosphoenolpyruvate synthase; Validated; Region: PRK06464 271848013163 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 271848013164 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 271848013165 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 271848013166 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 271848013167 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 271848013168 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 271848013169 SmpB-tmRNA interface; other site 271848013170 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 271848013171 putative coenzyme Q binding site [chemical binding]; other site 271848013172 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2914 271848013173 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 271848013174 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 271848013175 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 271848013176 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 271848013177 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 271848013178 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 271848013179 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 271848013180 active site 271848013181 GMP synthase; Reviewed; Region: guaA; PRK00074 271848013182 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 271848013183 AMP/PPi binding site [chemical binding]; other site 271848013184 candidate oxyanion hole; other site 271848013185 catalytic triad [active] 271848013186 potential glutamine specificity residues [chemical binding]; other site 271848013187 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 271848013188 ATP Binding subdomain [chemical binding]; other site 271848013189 Ligand Binding sites [chemical binding]; other site 271848013190 Dimerization subdomain; other site 271848013191 Domain of unknown function (DUF1993); Region: DUF1993; cl01567 271848013192 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 271848013193 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 271848013194 nucleoside/Zn binding site; other site 271848013195 dimer interface [polypeptide binding]; other site 271848013196 catalytic motif [active] 271848013197 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 271848013198 dimer interface [polypeptide binding]; other site 271848013199 catalytic triad [active] 271848013200 Transcriptional regulators [Transcription]; Region: GntR; COG1802 271848013201 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 271848013202 DNA-binding site [nucleotide binding]; DNA binding site 271848013203 FCD domain; Region: FCD; pfam07729 271848013204 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 271848013205 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 271848013206 Na binding site [ion binding]; other site 271848013207 putative substrate binding site [chemical binding]; other site 271848013208 Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126 271848013209 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 271848013210 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 271848013211 active site 271848013212 catalytic site [active] 271848013213 tetramer interface [polypeptide binding]; other site 271848013214 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195 271848013215 allantoicase; Provisional; Region: PRK13257 271848013216 Allantoicase repeat; Region: Allantoicase; pfam03561 271848013217 Allantoicase repeat; Region: Allantoicase; pfam03561 271848013218 ureidoglycolate hydrolase; Provisional; Region: PRK03606 271848013219 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 271848013220 Predicted membrane protein [Function unknown]; Region: COG3748 271848013221 Protein of unknown function (DUF989); Region: DUF989; pfam06181 271848013222 Cytochrome c; Region: Cytochrom_C; pfam00034 271848013223 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 271848013224 active site 271848013225 homotetramer interface [polypeptide binding]; other site 271848013226 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 271848013227 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 271848013228 active site 271848013229 putative substrate binding pocket [chemical binding]; other site 271848013230 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848013231 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848013232 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_4; cd08463 271848013233 putative substrate binding pocket [chemical binding]; other site 271848013234 putative dimerization interface [polypeptide binding]; other site 271848013235 Dodecin; Region: Dodecin; pfam07311 271848013236 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 271848013237 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 271848013238 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 271848013239 Transposase; Region: DDE_Tnp_ISL3; pfam01610 271848013240 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 271848013241 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 271848013242 Tetratricopeptide repeat; Region: TPR_16; pfam13432 271848013243 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 271848013244 TPR motif; other site 271848013245 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 271848013246 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 271848013247 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 271848013248 Transglycosylase; Region: Transgly; pfam00912 271848013249 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 271848013250 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 271848013251 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 271848013252 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 271848013253 tetramer interface [polypeptide binding]; other site 271848013254 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848013255 catalytic residue [active] 271848013256 acetylornithine deacetylase; Provisional; Region: PRK07522 271848013257 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 271848013258 metal binding site [ion binding]; metal-binding site 271848013259 putative dimer interface [polypeptide binding]; other site 271848013260 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 271848013261 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 271848013262 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 271848013263 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 271848013264 ATP binding site [chemical binding]; other site 271848013265 putative Mg++ binding site [ion binding]; other site 271848013266 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 271848013267 nucleotide binding region [chemical binding]; other site 271848013268 ATP-binding site [chemical binding]; other site 271848013269 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 271848013270 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 271848013271 substrate binding site; other site 271848013272 dimer interface; other site 271848013273 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 271848013274 homotrimer interaction site [polypeptide binding]; other site 271848013275 zinc binding site [ion binding]; other site 271848013276 CDP-binding sites; other site 271848013277 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 271848013278 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 271848013279 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 271848013280 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 271848013281 dimer interface [polypeptide binding]; other site 271848013282 decamer (pentamer of dimers) interface [polypeptide binding]; other site 271848013283 catalytic triad [active] 271848013284 peroxidatic and resolving cysteines [active] 271848013285 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 271848013286 HAMP domain; Region: HAMP; pfam00672 271848013287 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271848013288 dimer interface [polypeptide binding]; other site 271848013289 phosphorylation site [posttranslational modification] 271848013290 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848013291 ATP binding site [chemical binding]; other site 271848013292 Mg2+ binding site [ion binding]; other site 271848013293 G-X-G motif; other site 271848013294 osmolarity response regulator; Provisional; Region: ompR; PRK09468 271848013295 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848013296 active site 271848013297 phosphorylation site [posttranslational modification] 271848013298 intermolecular recognition site; other site 271848013299 dimerization interface [polypeptide binding]; other site 271848013300 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 271848013301 DNA binding site [nucleotide binding] 271848013302 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 271848013303 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 271848013304 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 271848013305 active site lid residues [active] 271848013306 substrate binding pocket [chemical binding]; other site 271848013307 catalytic residues [active] 271848013308 substrate-Mg2+ binding site; other site 271848013309 aspartate-rich region 1; other site 271848013310 aspartate-rich region 2; other site 271848013311 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 271848013312 PAAR motif; Region: PAAR_motif; pfam05488 271848013313 MEKHLA domain; Region: MEKHLA; pfam08670 271848013314 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 271848013315 PLD-like domain; Region: PLDc_2; pfam13091 271848013316 putative active site [active] 271848013317 catalytic site [active] 271848013318 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_1; cd09996 271848013319 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 271848013320 active site 271848013321 Zn binding site [ion binding]; other site 271848013322 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 271848013323 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 271848013324 trimer interface [polypeptide binding]; other site 271848013325 eyelet of channel; other site 271848013326 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 271848013327 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 271848013328 dimerization interface [polypeptide binding]; other site 271848013329 DNA binding residues [nucleotide binding] 271848013330 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 271848013331 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 271848013332 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 271848013333 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 271848013334 MarR family; Region: MarR_2; pfam12802 271848013335 MarR family; Region: MarR_2; cl17246 271848013336 Glycerate kinase family; Region: Gly_kinase; cl00841 271848013337 trigger factor; Provisional; Region: tig; PRK01490 271848013338 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 271848013339 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 271848013340 Clp protease; Region: CLP_protease; pfam00574 271848013341 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 271848013342 oligomer interface [polypeptide binding]; other site 271848013343 active site residues [active] 271848013344 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 271848013345 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 271848013346 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848013347 Walker A motif; other site 271848013348 ATP binding site [chemical binding]; other site 271848013349 Walker B motif; other site 271848013350 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 271848013351 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 271848013352 Found in ATP-dependent protease La (LON); Region: LON; smart00464 271848013353 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848013354 Walker A motif; other site 271848013355 ATP binding site [chemical binding]; other site 271848013356 Walker B motif; other site 271848013357 arginine finger; other site 271848013358 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 271848013359 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 271848013360 30S subunit binding site; other site 271848013361 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 271848013362 periplasmic folding chaperone; Provisional; Region: PRK10788 271848013363 SurA N-terminal domain; Region: SurA_N_3; cl07813 271848013364 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 271848013365 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 271848013366 active site 271848013367 catalytic triad [active] 271848013368 oxyanion hole [active] 271848013369 switch loop; other site 271848013370 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 271848013371 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 271848013372 Walker A/P-loop; other site 271848013373 ATP binding site [chemical binding]; other site 271848013374 Q-loop/lid; other site 271848013375 ABC transporter signature motif; other site 271848013376 Walker B; other site 271848013377 D-loop; other site 271848013378 H-loop/switch region; other site 271848013379 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 271848013380 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 271848013381 active site 271848013382 dimer interface [polypeptide binding]; other site 271848013383 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 271848013384 dimer interface [polypeptide binding]; other site 271848013385 active site 271848013386 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 271848013387 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 271848013388 putative substrate binding site [chemical binding]; other site 271848013389 putative ATP binding site [chemical binding]; other site 271848013390 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 271848013391 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 271848013392 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 271848013393 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 271848013394 dimerization interface [polypeptide binding]; other site 271848013395 ATP binding site [chemical binding]; other site 271848013396 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 271848013397 dimerization interface [polypeptide binding]; other site 271848013398 ATP binding site [chemical binding]; other site 271848013399 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 271848013400 putative active site [active] 271848013401 catalytic triad [active] 271848013402 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 271848013403 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 271848013404 BolA-like protein; Region: BolA; pfam01722 271848013405 intracellular septation protein A; Reviewed; Region: PRK00259 271848013406 methionine sulfoxide reductase B; Provisional; Region: PRK00222 271848013407 SelR domain; Region: SelR; pfam01641 271848013408 Uncharacterized conserved protein [Function unknown]; Region: COG0397 271848013409 hypothetical protein; Validated; Region: PRK00029 271848013410 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 271848013411 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 271848013412 dimer interface [polypeptide binding]; other site 271848013413 acyl-activating enzyme (AAE) consensus motif; other site 271848013414 putative active site [active] 271848013415 AMP binding site [chemical binding]; other site 271848013416 putative CoA binding site [chemical binding]; other site 271848013417 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 271848013418 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 271848013419 substrate binding site [chemical binding]; other site 271848013420 oxyanion hole (OAH) forming residues; other site 271848013421 trimer interface [polypeptide binding]; other site 271848013422 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 271848013423 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 271848013424 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 271848013425 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 271848013426 catalytic triad [active] 271848013427 metal binding site [ion binding]; metal-binding site 271848013428 conserved cis-peptide bond; other site 271848013429 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 271848013430 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 271848013431 dimer interface [polypeptide binding]; other site 271848013432 active site 271848013433 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 271848013434 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 271848013435 CoenzymeA binding site [chemical binding]; other site 271848013436 subunit interaction site [polypeptide binding]; other site 271848013437 PHB binding site; other site 271848013438 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 271848013439 Prostaglandin dehydrogenases; Region: PGDH; cd05288 271848013440 NAD(P) binding site [chemical binding]; other site 271848013441 substrate binding site [chemical binding]; other site 271848013442 dimer interface [polypeptide binding]; other site 271848013443 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 271848013444 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 271848013445 substrate binding pocket [chemical binding]; other site 271848013446 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 271848013447 NRDE protein; Region: NRDE; cl01315 271848013448 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 271848013449 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 271848013450 YceG-like family; Region: YceG; pfam02618 271848013451 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 271848013452 dimerization interface [polypeptide binding]; other site 271848013453 thymidylate kinase; Validated; Region: tmk; PRK00698 271848013454 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 271848013455 TMP-binding site; other site 271848013456 ATP-binding site [chemical binding]; other site 271848013457 DNA polymerase III subunit delta'; Validated; Region: PRK06964 271848013458 DNA polymerase III subunit delta'; Validated; Region: PRK08485 271848013459 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 271848013460 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 271848013461 Coenzyme A binding pocket [chemical binding]; other site 271848013462 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 271848013463 active site 271848013464 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 271848013465 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 271848013466 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 271848013467 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 271848013468 Mechanosensitive ion channel; Region: MS_channel; pfam00924 271848013469 Predicted ATPase [General function prediction only]; Region: COG4637 271848013470 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 271848013471 Walker A/P-loop; other site 271848013472 ATP binding site [chemical binding]; other site 271848013473 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 271848013474 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 271848013475 putative ADP-binding pocket [chemical binding]; other site 271848013476 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 271848013477 Domain of unknown function DUF221; Region: DUF221; pfam02714 271848013478 psiF repeat; Region: PsiF_repeat; pfam07769 271848013479 psiF repeat; Region: PsiF_repeat; pfam07769 271848013480 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 271848013481 active site 271848013482 homodimer interface [polypeptide binding]; other site 271848013483 homotetramer interface [polypeptide binding]; other site 271848013484 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 271848013485 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 271848013486 2-hydroxy-3-oxopropionate reductase; Region: tartro_sem_red; TIGR01505 271848013487 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 271848013488 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 271848013489 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 271848013490 glyoxylate carboligase; Provisional; Region: PRK11269 271848013491 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 271848013492 PYR/PP interface [polypeptide binding]; other site 271848013493 dimer interface [polypeptide binding]; other site 271848013494 TPP binding site [chemical binding]; other site 271848013495 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 271848013496 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 271848013497 TPP-binding site [chemical binding]; other site 271848013498 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848013499 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848013500 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 271848013501 putative effector binding pocket; other site 271848013502 dimerization interface [polypeptide binding]; other site 271848013503 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 271848013504 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 271848013505 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 271848013506 active site 271848013507 metal binding site [ion binding]; metal-binding site 271848013508 RNA polymerase sigma factor; Provisional; Region: PRK12533 271848013509 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 271848013510 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 271848013511 DNA binding residues [nucleotide binding] 271848013512 Putative zinc-finger; Region: zf-HC2; pfam13490 271848013513 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 271848013514 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 271848013515 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 271848013516 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 271848013517 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 271848013518 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 271848013519 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 271848013520 replicative DNA helicase; Provisional; Region: PRK07004 271848013521 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 271848013522 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 271848013523 Walker A motif; other site 271848013524 ATP binding site [chemical binding]; other site 271848013525 Walker B motif; other site 271848013526 DNA binding loops [nucleotide binding] 271848013527 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 271848013528 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 271848013529 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 271848013530 NlpC/P60 family; Region: NLPC_P60; pfam00877 271848013531 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 271848013532 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 271848013533 putative active site [active] 271848013534 PhoH-like protein; Region: PhoH; pfam02562 271848013535 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 271848013536 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 271848013537 catalytic triad [active] 271848013538 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 271848013539 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 271848013540 putative active site [active] 271848013541 putative catalytic site [active] 271848013542 putative Zn binding site [ion binding]; other site 271848013543 NAD-dependent epimerase/dehydratase family protein; Provisional; Region: PRK11908 271848013544 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 271848013545 NAD binding site [chemical binding]; other site 271848013546 substrate binding site [chemical binding]; other site 271848013547 active site 271848013548 putative formyltransferase; Provisional; Region: PRK06988 271848013549 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 271848013550 active site 271848013551 substrate binding site [chemical binding]; other site 271848013552 cosubstrate binding site; other site 271848013553 catalytic site [active] 271848013554 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 271848013555 active site 271848013556 hexamer interface [polypeptide binding]; other site 271848013557 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 271848013558 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 271848013559 Ligand binding site; other site 271848013560 Putative Catalytic site; other site 271848013561 DXD motif; other site 271848013562 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 271848013563 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 271848013564 inhibitor-cofactor binding pocket; inhibition site 271848013565 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848013566 catalytic residue [active] 271848013567 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 271848013568 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 271848013569 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 271848013570 Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome; Region: Xcc1710_like; cd05560 271848013571 aminotransferase AlaT; Validated; Region: PRK09265 271848013572 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 271848013573 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848013574 homodimer interface [polypeptide binding]; other site 271848013575 catalytic residue [active] 271848013576 homoserine dehydrogenase; Provisional; Region: PRK06349 271848013577 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 271848013578 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 271848013579 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 271848013580 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 271848013581 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 271848013582 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848013583 catalytic residue [active] 271848013584 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 271848013585 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 271848013586 dimer interface [polypeptide binding]; other site 271848013587 putative functional site; other site 271848013588 putative MPT binding site; other site 271848013589 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 271848013590 MoaE interaction surface [polypeptide binding]; other site 271848013591 MoeB interaction surface [polypeptide binding]; other site 271848013592 thiocarboxylated glycine; other site 271848013593 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 271848013594 MoaE homodimer interface [polypeptide binding]; other site 271848013595 MoaD interaction [polypeptide binding]; other site 271848013596 active site residues [active] 271848013597 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 271848013598 apolar tunnel; other site 271848013599 heme binding site [chemical binding]; other site 271848013600 dimerization interface [polypeptide binding]; other site 271848013601 Transcriptional regulator; Region: Rrf2; cl17282 271848013602 Rrf2 family protein; Region: rrf2_super; TIGR00738 271848013603 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 271848013604 Clp amino terminal domain; Region: Clp_N; pfam02861 271848013605 Clp amino terminal domain; Region: Clp_N; pfam02861 271848013606 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848013607 Walker A motif; other site 271848013608 ATP binding site [chemical binding]; other site 271848013609 Walker B motif; other site 271848013610 arginine finger; other site 271848013611 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848013612 Walker A motif; other site 271848013613 ATP binding site [chemical binding]; other site 271848013614 Walker B motif; other site 271848013615 arginine finger; other site 271848013616 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 271848013617 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 271848013618 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 271848013619 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 271848013620 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 271848013621 DNA binding residues [nucleotide binding] 271848013622 putative dimer interface [polypeptide binding]; other site 271848013623 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 271848013624 lipoyl synthase; Provisional; Region: PRK12928 271848013625 multidrug efflux protein; Reviewed; Region: PRK01766 271848013626 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 271848013627 cation binding site [ion binding]; other site 271848013628 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 271848013629 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 271848013630 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167 271848013631 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848013632 putative substrate translocation pore; other site 271848013633 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 271848013634 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 271848013635 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 271848013636 DNA binding residues [nucleotide binding] 271848013637 transcription termination factor Rho; Provisional; Region: rho; PRK09376 271848013638 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 271848013639 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 271848013640 RNA binding site [nucleotide binding]; other site 271848013641 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 271848013642 multimer interface [polypeptide binding]; other site 271848013643 Walker A motif; other site 271848013644 ATP binding site [chemical binding]; other site 271848013645 Walker B motif; other site 271848013646 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 271848013647 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 271848013648 catalytic residues [active] 271848013649 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07003 271848013650 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848013651 Walker A motif; other site 271848013652 ATP binding site [chemical binding]; other site 271848013653 Walker B motif; other site 271848013654 arginine finger; other site 271848013655 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 271848013656 hypothetical protein; Validated; Region: PRK00153 271848013657 recombination protein RecR; Reviewed; Region: recR; PRK00076 271848013658 RecR protein; Region: RecR; pfam02132 271848013659 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 271848013660 putative active site [active] 271848013661 putative metal-binding site [ion binding]; other site 271848013662 tetramer interface [polypeptide binding]; other site 271848013663 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 271848013664 CoA-transferase family III; Region: CoA_transf_3; pfam02515 271848013665 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 271848013666 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 271848013667 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848013668 S-adenosylmethionine binding site [chemical binding]; other site 271848013669 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 271848013670 Peptidase family M23; Region: Peptidase_M23; pfam01551 271848013671 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 271848013672 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 271848013673 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 271848013674 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 271848013675 DNA binding residues [nucleotide binding] 271848013676 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 271848013677 active site 271848013678 catalytic site [active] 271848013679 substrate binding site [chemical binding]; other site 271848013680 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 271848013681 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 271848013682 putative catalytic site [active] 271848013683 putative metal binding site [ion binding]; other site 271848013684 putative phosphate binding site [ion binding]; other site 271848013685 putative catalytic site [active] 271848013686 putative phosphate binding site [ion binding]; other site 271848013687 putative metal binding site [ion binding]; other site 271848013688 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 271848013689 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848013690 S-adenosylmethionine binding site [chemical binding]; other site 271848013691 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 271848013692 YccA-like proteins; Region: YccA_like; cd10433 271848013693 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 271848013694 active site 271848013695 multimer interface [polypeptide binding]; other site 271848013696 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 271848013697 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 271848013698 FeS/SAM binding site; other site 271848013699 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 271848013700 non-specific DNA binding site [nucleotide binding]; other site 271848013701 salt bridge; other site 271848013702 sequence-specific DNA binding site [nucleotide binding]; other site 271848013703 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 271848013704 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 271848013705 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 271848013706 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 271848013707 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 271848013708 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 271848013709 dimer interface [polypeptide binding]; other site 271848013710 motif 1; other site 271848013711 active site 271848013712 motif 2; other site 271848013713 motif 3; other site 271848013714 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 271848013715 anticodon binding site; other site 271848013716 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 271848013717 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 271848013718 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 271848013719 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 271848013720 Trp docking motif [polypeptide binding]; other site 271848013721 active site 271848013722 GTP-binding protein Der; Reviewed; Region: PRK00093 271848013723 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 271848013724 G1 box; other site 271848013725 GTP/Mg2+ binding site [chemical binding]; other site 271848013726 Switch I region; other site 271848013727 G2 box; other site 271848013728 Switch II region; other site 271848013729 G3 box; other site 271848013730 G4 box; other site 271848013731 G5 box; other site 271848013732 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 271848013733 G1 box; other site 271848013734 GTP/Mg2+ binding site [chemical binding]; other site 271848013735 Switch I region; other site 271848013736 G2 box; other site 271848013737 G3 box; other site 271848013738 Switch II region; other site 271848013739 G4 box; other site 271848013740 G5 box; other site 271848013741 bacterial Hfq-like; Region: Hfq; cd01716 271848013742 hexamer interface [polypeptide binding]; other site 271848013743 Sm1 motif; other site 271848013744 RNA binding site [nucleotide binding]; other site 271848013745 Sm2 motif; other site 271848013746 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 271848013747 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 271848013748 HflX GTPase family; Region: HflX; cd01878 271848013749 G1 box; other site 271848013750 GTP/Mg2+ binding site [chemical binding]; other site 271848013751 Switch I region; other site 271848013752 G2 box; other site 271848013753 G3 box; other site 271848013754 Switch II region; other site 271848013755 G4 box; other site 271848013756 G5 box; other site 271848013757 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 271848013758 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 271848013759 HflK protein; Region: hflK; TIGR01933 271848013760 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 271848013761 Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838 271848013762 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 271848013763 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 271848013764 dimer interface [polypeptide binding]; other site 271848013765 motif 1; other site 271848013766 active site 271848013767 motif 2; other site 271848013768 motif 3; other site 271848013769 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 271848013770 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 271848013771 GDP-binding site [chemical binding]; other site 271848013772 ACT binding site; other site 271848013773 IMP binding site; other site 271848013774 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 271848013775 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 271848013776 active site 271848013777 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 271848013778 potassium uptake protein; Region: kup; TIGR00794 271848013779 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 271848013780 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 271848013781 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 271848013782 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 271848013783 RNA binding site [nucleotide binding]; other site 271848013784 Protein of unknown function (DUF465); Region: DUF465; pfam04325 271848013785 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 271848013786 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 271848013787 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 271848013788 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 271848013789 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 271848013790 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 271848013791 RNA binding surface [nucleotide binding]; other site 271848013792 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 271848013793 active site 271848013794 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 271848013795 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 271848013796 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 271848013797 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 271848013798 putative acyltransferase; Provisional; Region: PRK05790 271848013799 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 271848013800 dimer interface [polypeptide binding]; other site 271848013801 active site 271848013802 acetyacetyl-CoA reductase; Provisional; Region: PRK12938 271848013803 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 271848013804 NAD(P) binding site [chemical binding]; other site 271848013805 homotetramer interface [polypeptide binding]; other site 271848013806 homodimer interface [polypeptide binding]; other site 271848013807 active site 271848013808 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394 271848013809 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 271848013810 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 271848013811 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 271848013812 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 271848013813 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 271848013814 FeS/SAM binding site; other site 271848013815 TRAM domain; Region: TRAM; cl01282 271848013816 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 271848013817 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 271848013818 substrate binding site [chemical binding]; other site 271848013819 ATP binding site [chemical binding]; other site 271848013820 beta-ketothiolase; Provisional; Region: PRK09051 271848013821 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 271848013822 dimer interface [polypeptide binding]; other site 271848013823 active site 271848013824 cystathionine beta-lyase; Provisional; Region: PRK07050 271848013825 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 271848013826 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 271848013827 catalytic residue [active] 271848013828 Domain of unknown function (DUF4072); Region: DUF4072; pfam13284 271848013829 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 271848013830 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 271848013831 motif II; other site 271848013832 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 271848013833 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 271848013834 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 271848013835 Walker A/P-loop; other site 271848013836 ATP binding site [chemical binding]; other site 271848013837 Q-loop/lid; other site 271848013838 ABC transporter signature motif; other site 271848013839 Walker B; other site 271848013840 D-loop; other site 271848013841 H-loop/switch region; other site 271848013842 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 271848013843 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 271848013844 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 271848013845 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 271848013846 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 271848013847 ABC transporter; Region: ABC_tran_2; pfam12848 271848013848 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 271848013849 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 271848013850 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 271848013851 trimer interface [polypeptide binding]; other site 271848013852 eyelet of channel; other site 271848013853 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 271848013854 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 271848013855 NAD binding site [chemical binding]; other site 271848013856 catalytic residues [active] 271848013857 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 271848013858 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 271848013859 FMN binding site [chemical binding]; other site 271848013860 substrate binding site [chemical binding]; other site 271848013861 putative catalytic residue [active] 271848013862 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 271848013863 Predicted Fe-S protein [General function prediction only]; Region: COG3313 271848013864 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 271848013865 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 271848013866 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 271848013867 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 271848013868 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 271848013869 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 271848013870 Walker A/P-loop; other site 271848013871 ATP binding site [chemical binding]; other site 271848013872 Q-loop/lid; other site 271848013873 ABC transporter signature motif; other site 271848013874 Walker B; other site 271848013875 D-loop; other site 271848013876 H-loop/switch region; other site 271848013877 TOBE domain; Region: TOBE_2; pfam08402 271848013878 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848013879 dimer interface [polypeptide binding]; other site 271848013880 conserved gate region; other site 271848013881 putative PBP binding loops; other site 271848013882 ABC-ATPase subunit interface; other site 271848013883 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 271848013884 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848013885 dimer interface [polypeptide binding]; other site 271848013886 conserved gate region; other site 271848013887 putative PBP binding loops; other site 271848013888 ABC-ATPase subunit interface; other site 271848013889 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 271848013890 Putative phosphatase (DUF442); Region: DUF442; cl17385 271848013891 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 271848013892 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 271848013893 PAS fold; Region: PAS_4; pfam08448 271848013894 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271848013895 putative active site [active] 271848013896 heme pocket [chemical binding]; other site 271848013897 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 271848013898 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848013899 Walker A motif; other site 271848013900 ATP binding site [chemical binding]; other site 271848013901 Walker B motif; other site 271848013902 arginine finger; other site 271848013903 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 271848013904 Predicted transcriptional regulator [Transcription]; Region: COG3655 271848013905 sequence-specific DNA binding site [nucleotide binding]; other site 271848013906 salt bridge; other site 271848013907 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 271848013908 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 271848013909 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 271848013910 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 271848013911 HlyD family secretion protein; Region: HlyD_3; pfam13437 271848013912 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 271848013913 putative voltage-gated ClC-type chloride channel ClcB; Provisional; Region: PRK01862 271848013914 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 271848013915 Cl- selectivity filter; other site 271848013916 Cl- binding residues [ion binding]; other site 271848013917 pore gating glutamate residue; other site 271848013918 dimer interface [polypeptide binding]; other site 271848013919 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 271848013920 Predicted membrane protein [Function unknown]; Region: COG2855 271848013921 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848013922 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848013923 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848013924 dimerization interface [polypeptide binding]; other site 271848013925 SdpI/YhfL protein family; Region: SdpI; pfam13630 271848013926 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 271848013927 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 271848013928 substrate binding site [chemical binding]; other site 271848013929 ATP binding site [chemical binding]; other site 271848013930 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848013931 D-galactonate transporter; Region: 2A0114; TIGR00893 271848013932 putative substrate translocation pore; other site 271848013933 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 271848013934 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 271848013935 dimerization interface [polypeptide binding]; other site 271848013936 ligand binding site [chemical binding]; other site 271848013937 NADP binding site [chemical binding]; other site 271848013938 catalytic site [active] 271848013939 Transcriptional regulators [Transcription]; Region: PurR; COG1609 271848013940 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 271848013941 DNA binding site [nucleotide binding] 271848013942 domain linker motif; other site 271848013943 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 271848013944 putative ligand binding site [chemical binding]; other site 271848013945 putative dimerization interface [polypeptide binding]; other site 271848013946 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 271848013947 Protein of unknown function (DUF3022); Region: DUF3022; pfam11226 271848013948 PGDYG protein; Region: PGDYG; pfam14083 271848013949 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 271848013950 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 271848013951 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 271848013952 AsnC family; Region: AsnC_trans_reg; pfam01037 271848013953 Double zinc ribbon; Region: DZR; pfam12773 271848013954 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 271848013955 TrkA-N domain; Region: TrkA_N; pfam02254 271848013956 AAA domain; Region: AAA_33; pfam13671 271848013957 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 271848013958 active site 271848013959 Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173 271848013960 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 271848013961 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 271848013962 oligomer interface [polypeptide binding]; other site 271848013963 metal binding site [ion binding]; metal-binding site 271848013964 metal binding site [ion binding]; metal-binding site 271848013965 putative Cl binding site [ion binding]; other site 271848013966 basic sphincter; other site 271848013967 hydrophobic gate; other site 271848013968 periplasmic entrance; other site 271848013969 YciI-like protein; Reviewed; Region: PRK12866 271848013970 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 271848013971 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 271848013972 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 271848013973 Mechanosensitive ion channel; Region: MS_channel; pfam00924 271848013974 Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901 271848013975 ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163 271848013976 4Fe-4S binding domain; Region: Fer4_5; pfam12801 271848013977 4Fe-4S binding domain; Region: Fer4_5; pfam12801 271848013978 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 271848013979 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 271848013980 NosL; Region: NosL; pfam05573 271848013981 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 271848013982 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 271848013983 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 271848013984 Walker A/P-loop; other site 271848013985 ATP binding site [chemical binding]; other site 271848013986 Q-loop/lid; other site 271848013987 ABC transporter signature motif; other site 271848013988 Walker B; other site 271848013989 D-loop; other site 271848013990 H-loop/switch region; other site 271848013991 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 271848013992 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 271848013993 nitrous-oxide reductase; Validated; Region: PRK02888 271848013994 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 271848013995 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 271848013996 ApbE family; Region: ApbE; pfam02424 271848013997 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 271848013998 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 271848013999 Walker A/P-loop; other site 271848014000 ATP binding site [chemical binding]; other site 271848014001 Q-loop/lid; other site 271848014002 Walker B; other site 271848014003 D-loop; other site 271848014004 H-loop/switch region; other site 271848014005 ABC-2 type transporter; Region: ABC2_membrane; cl17235 271848014006 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 271848014007 dihydroxyacetone kinase; Provisional; Region: PRK14479 271848014008 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 271848014009 DAK2 domain; Region: Dak2; pfam02734 271848014010 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 271848014011 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 271848014012 hydrophobic ligand binding site; other site 271848014013 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 271848014014 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 271848014015 iron-sulfur cluster [ion binding]; other site 271848014016 [2Fe-2S] cluster binding site [ion binding]; other site 271848014017 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 271848014018 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 271848014019 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 271848014020 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 271848014021 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 271848014022 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 271848014023 dimer interface [polypeptide binding]; other site 271848014024 active site 271848014025 metal binding site [ion binding]; metal-binding site 271848014026 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 271848014027 active site 271848014028 catalytic residues [active] 271848014029 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 271848014030 putative dimerization interface [polypeptide binding]; other site 271848014031 Transcriptional regulators [Transcription]; Region: PurR; COG1609 271848014032 putative ligand binding site [chemical binding]; other site 271848014033 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 271848014034 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848014035 xylose isomerase; Provisional; Region: PRK05474 271848014036 xylose isomerase; Region: xylose_isom_A; TIGR02630 271848014037 D-xylose ABC transporter, substrate-binding protein; Region: xylF; TIGR02634 271848014038 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 271848014039 putative ligand binding site [chemical binding]; other site 271848014040 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 271848014041 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 271848014042 Walker A/P-loop; other site 271848014043 ATP binding site [chemical binding]; other site 271848014044 Q-loop/lid; other site 271848014045 ABC transporter signature motif; other site 271848014046 Walker B; other site 271848014047 D-loop; other site 271848014048 H-loop/switch region; other site 271848014049 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 271848014050 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 271848014051 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 271848014052 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 271848014053 TM-ABC transporter signature motif; other site 271848014054 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 271848014055 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 271848014056 putative ligand binding site [chemical binding]; other site 271848014057 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 271848014058 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 271848014059 Walker A/P-loop; other site 271848014060 ATP binding site [chemical binding]; other site 271848014061 Q-loop/lid; other site 271848014062 ABC transporter signature motif; other site 271848014063 Walker B; other site 271848014064 D-loop; other site 271848014065 H-loop/switch region; other site 271848014066 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 271848014067 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 271848014068 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 271848014069 TM-ABC transporter signature motif; other site 271848014070 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 271848014071 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 271848014072 TM-ABC transporter signature motif; other site 271848014073 Transposase, Mutator family; Region: Transposase_mut; pfam00872 271848014074 MULE transposase domain; Region: MULE; pfam10551 271848014075 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 271848014076 Transposase, Mutator family; Region: Transposase_mut; pfam00872 271848014077 MULE transposase domain; Region: MULE; pfam10551 271848014078 Transposase, Mutator family; Region: Transposase_mut; pfam00872 271848014079 MULE transposase domain; Region: MULE; pfam10551 271848014080 Transposase domain (DUF772); Region: DUF772; pfam05598 271848014081 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 271848014082 Helix-turn-helix domain; Region: HTH_28; pfam13518 271848014083 Winged helix-turn helix; Region: HTH_29; pfam13551 271848014084 Homeodomain-like domain; Region: HTH_32; pfam13565 271848014085 Lipoxygenase; Region: Lipoxygenase; pfam00305 271848014086 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 271848014087 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 271848014088 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 271848014089 peptidase domain interface [polypeptide binding]; other site 271848014090 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 271848014091 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 271848014092 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 271848014093 Condensation domain; Region: Condensation; pfam00668 271848014094 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 271848014095 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 271848014096 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 271848014097 Phosphotransferase enzyme family; Region: APH; pfam01636 271848014098 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 271848014099 putative active site [active] 271848014100 putative substrate binding site [chemical binding]; other site 271848014101 ATP binding site [chemical binding]; other site 271848014102 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 271848014103 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 271848014104 active site 271848014105 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 271848014106 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 271848014107 active site 271848014108 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 271848014109 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 271848014110 putative NADP binding site [chemical binding]; other site 271848014111 active site 271848014112 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 271848014113 Condensation domain; Region: Condensation; pfam00668 271848014114 peptide synthase; Provisional; Region: PRK12467 271848014115 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 271848014116 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 271848014117 acyl-activating enzyme (AAE) consensus motif; other site 271848014118 AMP binding site [chemical binding]; other site 271848014119 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 271848014120 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 271848014121 acyl-activating enzyme (AAE) consensus motif; other site 271848014122 AMP binding site [chemical binding]; other site 271848014123 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 271848014124 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 271848014125 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 271848014126 acyl-activating enzyme (AAE) consensus motif; other site 271848014127 AMP binding site [chemical binding]; other site 271848014128 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 271848014129 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 271848014130 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 271848014131 active site 271848014132 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848014133 NAD(P) binding site [chemical binding]; other site 271848014134 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 271848014135 active site 271848014136 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 271848014137 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 271848014138 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 271848014139 active site 271848014140 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 271848014141 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 271848014142 KR domain; Region: KR; pfam08659 271848014143 putative NADP binding site [chemical binding]; other site 271848014144 active site 271848014145 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 271848014146 acyl-CoA synthetase; Validated; Region: PRK05850 271848014147 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 271848014148 acyl-activating enzyme (AAE) consensus motif; other site 271848014149 active site 271848014150 Condensation domain; Region: Condensation; pfam00668 271848014151 Nonribosomal peptide synthase; Region: NRPS; pfam08415 271848014152 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 271848014153 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 271848014154 acyl-activating enzyme (AAE) consensus motif; other site 271848014155 AMP binding site [chemical binding]; other site 271848014156 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 271848014157 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848014158 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848014159 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 271848014160 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 271848014161 trimer interface [polypeptide binding]; other site 271848014162 eyelet of channel; other site 271848014163 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 271848014164 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848014165 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 271848014166 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 271848014167 EamA-like transporter family; Region: EamA; pfam00892 271848014168 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 271848014169 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 271848014170 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 271848014171 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 271848014172 dimer interface [polypeptide binding]; other site 271848014173 putative CheW interface [polypeptide binding]; other site 271848014174 Protein of unknown function (DUF3562); Region: DUF3562; pfam12085 271848014175 AMP-binding domain protein; Validated; Region: PRK07529 271848014176 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 271848014177 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_4; cd05944 271848014178 acyl-activating enzyme (AAE) consensus motif; other site 271848014179 putative AMP binding site [chemical binding]; other site 271848014180 putative active site [active] 271848014181 putative CoA binding site [chemical binding]; other site 271848014182 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848014183 S-adenosylmethionine binding site [chemical binding]; other site 271848014184 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 271848014185 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848014186 dimer interface [polypeptide binding]; other site 271848014187 conserved gate region; other site 271848014188 ABC-ATPase subunit interface; other site 271848014189 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 271848014190 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 271848014191 Walker A/P-loop; other site 271848014192 ATP binding site [chemical binding]; other site 271848014193 Q-loop/lid; other site 271848014194 ABC transporter signature motif; other site 271848014195 Walker B; other site 271848014196 D-loop; other site 271848014197 H-loop/switch region; other site 271848014198 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848014199 ABC-ATPase subunit interface; other site 271848014200 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 271848014201 arginine deiminase; Provisional; Region: PRK01388 271848014202 ornithine carbamoyltransferase; Validated; Region: PRK02102 271848014203 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 271848014204 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 271848014205 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 271848014206 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 271848014207 putative substrate binding site [chemical binding]; other site 271848014208 nucleotide binding site [chemical binding]; other site 271848014209 nucleotide binding site [chemical binding]; other site 271848014210 homodimer interface [polypeptide binding]; other site 271848014211 short chain dehydrogenase; Provisional; Region: PRK09291 271848014212 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848014213 NAD(P) binding site [chemical binding]; other site 271848014214 active site 271848014215 Domain of unknown function (DUF336); Region: DUF336; cl01249 271848014216 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848014217 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848014218 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 271848014219 putative effector binding pocket; other site 271848014220 putative dimerization interface [polypeptide binding]; other site 271848014221 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 271848014222 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 271848014223 C-terminal domain interface [polypeptide binding]; other site 271848014224 GSH binding site (G-site) [chemical binding]; other site 271848014225 dimer interface [polypeptide binding]; other site 271848014226 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 271848014227 dimer interface [polypeptide binding]; other site 271848014228 N-terminal domain interface [polypeptide binding]; other site 271848014229 MarR family; Region: MarR_2; cl17246 271848014230 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 271848014231 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 271848014232 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 271848014233 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 271848014234 active site 271848014235 SAM binding site [chemical binding]; other site 271848014236 homodimer interface [polypeptide binding]; other site 271848014237 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 271848014238 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 271848014239 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 271848014240 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 271848014241 active site 271848014242 putative homodimer interface [polypeptide binding]; other site 271848014243 SAM binding site [chemical binding]; other site 271848014244 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 271848014245 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848014246 S-adenosylmethionine binding site [chemical binding]; other site 271848014247 precorrin-3B synthase; Region: CobG; TIGR02435 271848014248 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 271848014249 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 271848014250 Precorrin-8X methylmutase; Region: CbiC; pfam02570 271848014251 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 271848014252 active site 271848014253 SAM binding site [chemical binding]; other site 271848014254 homodimer interface [polypeptide binding]; other site 271848014255 Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073 271848014256 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 271848014257 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 271848014258 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 271848014259 active site 271848014260 SAM binding site [chemical binding]; other site 271848014261 homodimer interface [polypeptide binding]; other site 271848014262 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 271848014263 active site 271848014264 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 271848014265 aromatic chitin/cellulose binding site residues [chemical binding]; other site 271848014266 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 271848014267 aromatic chitin/cellulose binding site residues [chemical binding]; other site 271848014268 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 271848014269 putative hydrolase; Provisional; Region: PRK11460 271848014270 Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240 271848014271 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 271848014272 metal ion-dependent adhesion site (MIDAS); other site 271848014273 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848014274 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 271848014275 Walker A motif; other site 271848014276 ATP binding site [chemical binding]; other site 271848014277 Walker B motif; other site 271848014278 arginine finger; other site 271848014279 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 271848014280 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 271848014281 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 271848014282 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 271848014283 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 271848014284 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 271848014285 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 271848014286 cobalamin biosynthesis protein CbiG; Provisional; Region: PRK07027 271848014287 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 271848014288 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 271848014289 homodimer interface [polypeptide binding]; other site 271848014290 Walker A motif; other site 271848014291 ATP binding site [chemical binding]; other site 271848014292 hydroxycobalamin binding site [chemical binding]; other site 271848014293 Walker B motif; other site 271848014294 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 271848014295 catalytic triad [active] 271848014296 Inclusion body protein; Region: PixA; pfam12306 271848014297 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 271848014298 catalytic site [active] 271848014299 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 271848014300 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 271848014301 N-terminal plug; other site 271848014302 ligand-binding site [chemical binding]; other site 271848014303 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 271848014304 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 271848014305 Condensation domain; Region: Condensation; pfam00668 271848014306 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 271848014307 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 271848014308 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 271848014309 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 271848014310 acyl-activating enzyme (AAE) consensus motif; other site 271848014311 AMP binding site [chemical binding]; other site 271848014312 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 271848014313 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 271848014314 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 271848014315 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 271848014316 acyl-activating enzyme (AAE) consensus motif; other site 271848014317 AMP binding site [chemical binding]; other site 271848014318 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 271848014319 Condensation domain; Region: Condensation; pfam00668 271848014320 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 271848014321 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 271848014322 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 271848014323 acyl-activating enzyme (AAE) consensus motif; other site 271848014324 AMP binding site [chemical binding]; other site 271848014325 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 271848014326 Condensation domain; Region: Condensation; pfam00668 271848014327 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 271848014328 Condensation domain; Region: Condensation; pfam00668 271848014329 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 271848014330 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 271848014331 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 271848014332 acyl-activating enzyme (AAE) consensus motif; other site 271848014333 AMP binding site [chemical binding]; other site 271848014334 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 271848014335 cyclic peptide transporter; Region: cyc_pep_trnsptr; TIGR01194 271848014336 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 271848014337 Walker A/P-loop; other site 271848014338 ATP binding site [chemical binding]; other site 271848014339 Q-loop/lid; other site 271848014340 ABC transporter signature motif; other site 271848014341 Walker B; other site 271848014342 D-loop; other site 271848014343 H-loop/switch region; other site 271848014344 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 271848014345 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 271848014346 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 271848014347 siderophore binding site; other site 271848014348 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 271848014349 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 271848014350 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 271848014351 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 271848014352 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 271848014353 dimer interface [polypeptide binding]; other site 271848014354 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 271848014355 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 271848014356 ABC-ATPase subunit interface; other site 271848014357 dimer interface [polypeptide binding]; other site 271848014358 putative PBP binding regions; other site 271848014359 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 271848014360 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 271848014361 Walker A/P-loop; other site 271848014362 ATP binding site [chemical binding]; other site 271848014363 Q-loop/lid; other site 271848014364 ABC transporter signature motif; other site 271848014365 Walker B; other site 271848014366 D-loop; other site 271848014367 H-loop/switch region; other site 271848014368 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 271848014369 MbtH-like protein; Region: MbtH; cl01279 271848014370 extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037 271848014371 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 271848014372 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 271848014373 short chain dehydrogenase; Provisional; Region: PRK07060 271848014374 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848014375 NAD(P) binding site [chemical binding]; other site 271848014376 active site 271848014377 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 271848014378 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 271848014379 N- and C-terminal domain interface [polypeptide binding]; other site 271848014380 putative active site [active] 271848014381 MgATP binding site [chemical binding]; other site 271848014382 catalytic site [active] 271848014383 metal binding site [ion binding]; metal-binding site 271848014384 putative xylulose binding site [chemical binding]; other site 271848014385 putative homodimer interface [polypeptide binding]; other site 271848014386 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 271848014387 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 271848014388 NAD(P) binding site [chemical binding]; other site 271848014389 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 271848014390 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 271848014391 TM-ABC transporter signature motif; other site 271848014392 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 271848014393 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 271848014394 Walker A/P-loop; other site 271848014395 ATP binding site [chemical binding]; other site 271848014396 Q-loop/lid; other site 271848014397 ABC transporter signature motif; other site 271848014398 Walker B; other site 271848014399 D-loop; other site 271848014400 H-loop/switch region; other site 271848014401 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 271848014402 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 271848014403 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 271848014404 putative ligand binding site [chemical binding]; other site 271848014405 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 271848014406 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 271848014407 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848014408 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 271848014409 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 271848014410 Ligand Binding Site [chemical binding]; other site 271848014411 Molecular Tunnel; other site 271848014412 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 271848014413 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 271848014414 Walker A/P-loop; other site 271848014415 ATP binding site [chemical binding]; other site 271848014416 Q-loop/lid; other site 271848014417 ABC transporter signature motif; other site 271848014418 Walker B; other site 271848014419 D-loop; other site 271848014420 H-loop/switch region; other site 271848014421 Fimbrial protein; Region: Fimbrial; pfam00419 271848014422 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 271848014423 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 271848014424 multidrug efflux protein; Reviewed; Region: PRK09577 271848014425 Protein export membrane protein; Region: SecD_SecF; cl14618 271848014426 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 271848014427 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 271848014428 HlyD family secretion protein; Region: HlyD_3; pfam13437 271848014429 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 271848014430 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 271848014431 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 271848014432 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 271848014433 Peptidase family M23; Region: Peptidase_M23; pfam01551 271848014434 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848014435 dimer interface [polypeptide binding]; other site 271848014436 conserved gate region; other site 271848014437 putative PBP binding loops; other site 271848014438 ABC-ATPase subunit interface; other site 271848014439 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848014440 dimer interface [polypeptide binding]; other site 271848014441 conserved gate region; other site 271848014442 putative PBP binding loops; other site 271848014443 ABC-ATPase subunit interface; other site 271848014444 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 271848014445 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 271848014446 substrate binding pocket [chemical binding]; other site 271848014447 membrane-bound complex binding site; other site 271848014448 hinge residues; other site 271848014449 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 271848014450 TadE-like protein; Region: TadE; pfam07811 271848014451 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 271848014452 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 271848014453 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 271848014454 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 271848014455 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 271848014456 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 271848014457 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 271848014458 ATP binding site [chemical binding]; other site 271848014459 Walker A motif; other site 271848014460 hexamer interface [polypeptide binding]; other site 271848014461 Walker B motif; other site 271848014462 AAA domain; Region: AAA_31; pfam13614 271848014463 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 271848014464 Type IV pili component [Cell motility and secretion]; Region: COG5461 271848014465 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 271848014466 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 271848014467 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 271848014468 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 271848014469 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 271848014470 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 271848014471 Walker A/P-loop; other site 271848014472 ATP binding site [chemical binding]; other site 271848014473 Q-loop/lid; other site 271848014474 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 271848014475 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848014476 putative substrate translocation pore; other site 271848014477 SpoVR family protein; Provisional; Region: PRK11767 271848014478 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 271848014479 hypothetical protein; Provisional; Region: PRK05325 271848014480 PrkA family serine protein kinase; Provisional; Region: PRK15455 271848014481 AAA ATPase domain; Region: AAA_16; pfam13191 271848014482 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 271848014483 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 271848014484 Tar ligand binding domain homologue; Region: TarH; pfam02203 271848014485 dimer interface [polypeptide binding]; other site 271848014486 ligand binding site [chemical binding]; other site 271848014487 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 271848014488 dimerization interface [polypeptide binding]; other site 271848014489 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 271848014490 dimer interface [polypeptide binding]; other site 271848014491 putative CheW interface [polypeptide binding]; other site 271848014492 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 271848014493 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 271848014494 substrate binding site [chemical binding]; other site 271848014495 dimer interface [polypeptide binding]; other site 271848014496 ATP binding site [chemical binding]; other site 271848014497 Transcriptional regulators [Transcription]; Region: PurR; COG1609 271848014498 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 271848014499 DNA binding site [nucleotide binding] 271848014500 domain linker motif; other site 271848014501 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 271848014502 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 271848014503 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 271848014504 TM-ABC transporter signature motif; other site 271848014505 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 271848014506 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 271848014507 Walker A/P-loop; other site 271848014508 ATP binding site [chemical binding]; other site 271848014509 Q-loop/lid; other site 271848014510 ABC transporter signature motif; other site 271848014511 Walker B; other site 271848014512 D-loop; other site 271848014513 H-loop/switch region; other site 271848014514 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 271848014515 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 271848014516 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 271848014517 ligand binding site [chemical binding]; other site 271848014518 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12683 271848014519 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848014520 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 271848014521 substrate binding site [chemical binding]; other site 271848014522 dimerization interface [polypeptide binding]; other site 271848014523 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 271848014524 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 271848014525 Walker A/P-loop; other site 271848014526 ATP binding site [chemical binding]; other site 271848014527 Q-loop/lid; other site 271848014528 ABC transporter signature motif; other site 271848014529 Walker B; other site 271848014530 D-loop; other site 271848014531 H-loop/switch region; other site 271848014532 TOBE-like domain; Region: TOBE_3; pfam12857 271848014533 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 271848014534 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848014535 dimer interface [polypeptide binding]; other site 271848014536 conserved gate region; other site 271848014537 putative PBP binding loops; other site 271848014538 ABC-ATPase subunit interface; other site 271848014539 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 271848014540 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848014541 dimer interface [polypeptide binding]; other site 271848014542 conserved gate region; other site 271848014543 putative PBP binding loops; other site 271848014544 ABC-ATPase subunit interface; other site 271848014545 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 271848014546 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 271848014547 substrate binding pocket [chemical binding]; other site 271848014548 membrane-bound complex binding site; other site 271848014549 LexA repressor; Validated; Region: PRK00215 271848014550 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 271848014551 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 271848014552 Catalytic site [active] 271848014553 Protein of unknown function (DUF2939); Region: DUF2939; pfam11159 271848014554 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 271848014555 Ligand Binding Site [chemical binding]; other site 271848014556 nodulation ABC transporter NodI; Provisional; Region: PRK13537 271848014557 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 271848014558 Walker A/P-loop; other site 271848014559 ATP binding site [chemical binding]; other site 271848014560 Q-loop/lid; other site 271848014561 ABC transporter signature motif; other site 271848014562 Walker B; other site 271848014563 D-loop; other site 271848014564 H-loop/switch region; other site 271848014565 ABC-2 type transporter; Region: ABC2_membrane; cl17235 271848014566 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 271848014567 Predicted permease; Region: DUF318; cl17795 271848014568 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 271848014569 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 271848014570 active site 271848014571 catalytic tetrad [active] 271848014572 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 271848014573 CoenzymeA binding site [chemical binding]; other site 271848014574 subunit interaction site [polypeptide binding]; other site 271848014575 PHB binding site; other site 271848014576 Predicted transcriptional regulators [Transcription]; Region: COG1733 271848014577 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 271848014578 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 271848014579 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 271848014580 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 271848014581 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 271848014582 FMN binding site [chemical binding]; other site 271848014583 active site 271848014584 catalytic residues [active] 271848014585 substrate binding site [chemical binding]; other site 271848014586 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 271848014587 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 271848014588 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 271848014589 Walker A/P-loop; other site 271848014590 ATP binding site [chemical binding]; other site 271848014591 Q-loop/lid; other site 271848014592 ABC transporter signature motif; other site 271848014593 Walker B; other site 271848014594 D-loop; other site 271848014595 H-loop/switch region; other site 271848014596 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 271848014597 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848014598 dimer interface [polypeptide binding]; other site 271848014599 conserved gate region; other site 271848014600 putative PBP binding loops; other site 271848014601 ABC-ATPase subunit interface; other site 271848014602 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 271848014603 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 271848014604 active site 271848014605 dimer interface [polypeptide binding]; other site 271848014606 non-prolyl cis peptide bond; other site 271848014607 insertion regions; other site 271848014608 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 271848014609 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 271848014610 substrate binding site [chemical binding]; other site 271848014611 oxyanion hole (OAH) forming residues; other site 271848014612 trimer interface [polypeptide binding]; other site 271848014613 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 271848014614 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 271848014615 hypothetical protein; Provisional; Region: PRK02487 271848014616 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 271848014617 nudix motif; other site 271848014618 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 271848014619 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 271848014620 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 271848014621 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 271848014622 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 271848014623 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 271848014624 quinone interaction residues [chemical binding]; other site 271848014625 active site 271848014626 catalytic residues [active] 271848014627 FMN binding site [chemical binding]; other site 271848014628 substrate binding site [chemical binding]; other site 271848014629 cystine transporter subunit; Provisional; Region: PRK11260 271848014630 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 271848014631 substrate binding pocket [chemical binding]; other site 271848014632 membrane-bound complex binding site; other site 271848014633 hinge residues; other site 271848014634 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 271848014635 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848014636 dimer interface [polypeptide binding]; other site 271848014637 conserved gate region; other site 271848014638 putative PBP binding loops; other site 271848014639 ABC-ATPase subunit interface; other site 271848014640 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 271848014641 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 271848014642 Transcriptional regulators [Transcription]; Region: FadR; COG2186 271848014643 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 271848014644 DNA-binding site [nucleotide binding]; DNA binding site 271848014645 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 271848014646 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 271848014647 tetramer (dimer of dimers) interface [polypeptide binding]; other site 271848014648 active site 271848014649 dimer interface [polypeptide binding]; other site 271848014650 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 271848014651 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 271848014652 amidase catalytic site [active] 271848014653 Zn binding residues [ion binding]; other site 271848014654 substrate binding site [chemical binding]; other site 271848014655 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 271848014656 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 271848014657 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 271848014658 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 271848014659 ribonuclease R; Region: RNase_R; TIGR02063 271848014660 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 271848014661 RNB domain; Region: RNB; pfam00773 271848014662 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 271848014663 RNA binding site [nucleotide binding]; other site 271848014664 HAMP domain; Region: HAMP; pfam00672 271848014665 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 271848014666 dimer interface [polypeptide binding]; other site 271848014667 putative CheW interface [polypeptide binding]; other site 271848014668 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 271848014669 metal binding site [ion binding]; metal-binding site 271848014670 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 271848014671 Sulfate transporter family; Region: Sulfate_transp; pfam00916 271848014672 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 271848014673 Putative ParB-like nuclease; Region: ParBc_2; pfam08857 271848014674 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 271848014675 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 271848014676 putative sialic acid transporter; Region: 2A0112; TIGR00891 271848014677 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848014678 putative substrate translocation pore; other site 271848014679 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 271848014680 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 271848014681 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 271848014682 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 271848014683 acyl-activating enzyme (AAE) consensus motif; other site 271848014684 putative AMP binding site [chemical binding]; other site 271848014685 putative active site [active] 271848014686 putative CoA binding site [chemical binding]; other site 271848014687 Protein of unknown function (DUF1571); Region: DUF1571; pfam07608 271848014688 bacterial Hfq-like; Region: Hfq; cd01716 271848014689 hexamer interface [polypeptide binding]; other site 271848014690 Sm1 motif; other site 271848014691 RNA binding site [nucleotide binding]; other site 271848014692 Sm2 motif; other site 271848014693 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 271848014694 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 271848014695 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848014696 Walker A motif; other site 271848014697 ATP binding site [chemical binding]; other site 271848014698 Walker B motif; other site 271848014699 arginine finger; other site 271848014700 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 271848014701 Predicted membrane protein [Function unknown]; Region: COG4655 271848014702 Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977 271848014703 Protein of unknown function (DUF3613); Region: DUF3613; pfam12266 271848014704 TPR repeat; Region: TPR_11; pfam13414 271848014705 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 271848014706 binding surface 271848014707 TPR motif; other site 271848014708 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 271848014709 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 271848014710 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 271848014711 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 271848014712 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 271848014713 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 271848014714 ATP binding site [chemical binding]; other site 271848014715 Walker A motif; other site 271848014716 hexamer interface [polypeptide binding]; other site 271848014717 Walker B motif; other site 271848014718 AAA domain; Region: AAA_31; pfam13614 271848014719 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 271848014720 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 271848014721 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 271848014722 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 271848014723 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 271848014724 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 271848014725 TadE-like protein; Region: TadE; pfam07811 271848014726 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 271848014727 Flp/Fap pilin component; Region: Flp_Fap; cl01585 271848014728 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 271848014729 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 271848014730 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 271848014731 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 271848014732 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 271848014733 Predicted ATPase [General function prediction only]; Region: COG1485 271848014734 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 271848014735 Walker B; other site 271848014736 D-loop; other site 271848014737 H-loop/switch region; other site 271848014738 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 271848014739 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 271848014740 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 271848014741 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 271848014742 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 271848014743 E3 interaction surface; other site 271848014744 lipoyl attachment site [posttranslational modification]; other site 271848014745 e3 binding domain; Region: E3_binding; pfam02817 271848014746 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 271848014747 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 271848014748 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 271848014749 TPP-binding site [chemical binding]; other site 271848014750 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 271848014751 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 271848014752 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 271848014753 G1 box; other site 271848014754 putative GEF interaction site [polypeptide binding]; other site 271848014755 GTP/Mg2+ binding site [chemical binding]; other site 271848014756 Switch I region; other site 271848014757 G2 box; other site 271848014758 G3 box; other site 271848014759 Switch II region; other site 271848014760 G4 box; other site 271848014761 G5 box; other site 271848014762 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 271848014763 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 271848014764 Transcriptional regulators [Transcription]; Region: MarR; COG1846 271848014765 MarR family; Region: MarR_2; cl17246 271848014766 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 271848014767 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 271848014768 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 271848014769 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 271848014770 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 271848014771 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848014772 putative substrate translocation pore; other site 271848014773 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848014774 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01851 271848014775 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 271848014776 RNA binding site [nucleotide binding]; other site 271848014777 active site 271848014778 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 271848014779 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 271848014780 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 271848014781 translation initiation factor IF-2; Region: IF-2; TIGR00487 271848014782 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 271848014783 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 271848014784 G1 box; other site 271848014785 putative GEF interaction site [polypeptide binding]; other site 271848014786 GTP/Mg2+ binding site [chemical binding]; other site 271848014787 Switch I region; other site 271848014788 G2 box; other site 271848014789 G3 box; other site 271848014790 Switch II region; other site 271848014791 G4 box; other site 271848014792 G5 box; other site 271848014793 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 271848014794 Translation-initiation factor 2; Region: IF-2; pfam11987 271848014795 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 271848014796 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 271848014797 NusA N-terminal domain; Region: NusA_N; pfam08529 271848014798 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 271848014799 RNA binding site [nucleotide binding]; other site 271848014800 homodimer interface [polypeptide binding]; other site 271848014801 NusA-like KH domain; Region: KH_5; pfam13184 271848014802 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 271848014803 G-X-X-G motif; other site 271848014804 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 271848014805 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 271848014806 ribosome maturation protein RimP; Reviewed; Region: PRK00092 271848014807 Sm and related proteins; Region: Sm_like; cl00259 271848014808 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 271848014809 putative oligomer interface [polypeptide binding]; other site 271848014810 putative RNA binding site [nucleotide binding]; other site 271848014811 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 271848014812 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 271848014813 RNA binding surface [nucleotide binding]; other site 271848014814 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 271848014815 probable active site [active] 271848014816 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 271848014817 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848014818 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848014819 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 271848014820 putative dimerization interface [polypeptide binding]; other site 271848014821 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 271848014822 Uncharacterized conserved protein [Function unknown]; Region: COG1434 271848014823 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 271848014824 putative active site [active] 271848014825 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 271848014826 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 271848014827 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 271848014828 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 271848014829 Protein of unknown function (DUF2844); Region: DUF2844; pfam11005 271848014830 Protein of unknown function (DUF3443); Region: DUF3443; pfam11925 271848014831 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 271848014832 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 271848014833 Transposase; Region: DDE_Tnp_ISL3; pfam01610 271848014834 IS2 transposase TnpB; Reviewed; Region: PRK09409 271848014835 HTH-like domain; Region: HTH_21; pfam13276 271848014836 Integrase core domain; Region: rve; pfam00665 271848014837 Integrase core domain; Region: rve_3; pfam13683 271848014838 Transposase; Region: HTH_Tnp_1; cl17663 271848014839 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 271848014840 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 271848014841 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 271848014842 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 271848014843 DNA binding residues [nucleotide binding] 271848014844 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 271848014845 IHF dimer interface [polypeptide binding]; other site 271848014846 IHF - DNA interface [nucleotide binding]; other site 271848014847 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 271848014848 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 271848014849 putative tRNA-binding site [nucleotide binding]; other site 271848014850 B3/4 domain; Region: B3_4; pfam03483 271848014851 tRNA synthetase B5 domain; Region: B5; smart00874 271848014852 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 271848014853 dimer interface [polypeptide binding]; other site 271848014854 motif 1; other site 271848014855 motif 3; other site 271848014856 motif 2; other site 271848014857 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 271848014858 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 271848014859 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 271848014860 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 271848014861 dimer interface [polypeptide binding]; other site 271848014862 motif 1; other site 271848014863 active site 271848014864 motif 2; other site 271848014865 motif 3; other site 271848014866 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 271848014867 23S rRNA binding site [nucleotide binding]; other site 271848014868 L21 binding site [polypeptide binding]; other site 271848014869 L13 binding site [polypeptide binding]; other site 271848014870 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 271848014871 translation initiation factor IF-3; Region: infC; TIGR00168 271848014872 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 271848014873 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 271848014874 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 271848014875 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 271848014876 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 271848014877 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 271848014878 active site 271848014879 dimer interface [polypeptide binding]; other site 271848014880 motif 1; other site 271848014881 motif 2; other site 271848014882 motif 3; other site 271848014883 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 271848014884 anticodon binding site; other site 271848014885 HD domain; Region: HD_4; pfam13328 271848014886 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 271848014887 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 271848014888 synthetase active site [active] 271848014889 NTP binding site [chemical binding]; other site 271848014890 metal binding site [ion binding]; metal-binding site 271848014891 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 271848014892 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 271848014893 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 271848014894 homotrimer interaction site [polypeptide binding]; other site 271848014895 putative active site [active] 271848014896 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 271848014897 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 271848014898 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 271848014899 Protein of unknown function (DUF1641); Region: DUF1641; cl01025 271848014900 transcriptional regulator; Provisional; Region: PRK10632 271848014901 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848014902 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 271848014903 putative effector binding pocket; other site 271848014904 dimerization interface [polypeptide binding]; other site 271848014905 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 271848014906 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 271848014907 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 271848014908 short chain dehydrogenase; Provisional; Region: PRK06125 271848014909 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848014910 NAD(P) binding site [chemical binding]; other site 271848014911 active site 271848014912 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 271848014913 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 271848014914 PAS domain; Region: PAS_9; pfam13426 271848014915 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271848014916 putative active site [active] 271848014917 heme pocket [chemical binding]; other site 271848014918 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 271848014919 DNA binding residues [nucleotide binding] 271848014920 dimerization interface [polypeptide binding]; other site 271848014921 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 271848014922 active site 271848014923 short chain dehydrogenase; Provisional; Region: PRK06949 271848014924 classical (c) SDRs; Region: SDR_c; cd05233 271848014925 NAD(P) binding site [chemical binding]; other site 271848014926 active site 271848014927 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 271848014928 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 271848014929 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 271848014930 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 271848014931 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 271848014932 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 271848014933 Tetramer interface [polypeptide binding]; other site 271848014934 active site 271848014935 FMN-binding site [chemical binding]; other site 271848014936 lysophospholipid transporter LplT; Provisional; Region: PRK11195 271848014937 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 271848014938 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 271848014939 putative acyl-acceptor binding pocket; other site 271848014940 FOG: CBS domain [General function prediction only]; Region: COG0517 271848014941 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 271848014942 Protein of unknown function (DUF962); Region: DUF962; cl01879 271848014943 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 271848014944 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 271848014945 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 271848014946 Predicted membrane protein (DUF2069); Region: DUF2069; pfam09842 271848014947 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 271848014948 FAD binding domain; Region: FAD_binding_4; pfam01565 271848014949 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 271848014950 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 271848014951 active site 271848014952 metal binding site [ion binding]; metal-binding site 271848014953 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 271848014954 transcriptional regulator; Provisional; Region: PRK10632 271848014955 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 271848014956 putative effector binding pocket; other site 271848014957 dimerization interface [polypeptide binding]; other site 271848014958 multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459 271848014959 Fusaric acid resistance protein family; Region: FUSC; pfam04632 271848014960 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 271848014961 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 271848014962 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 271848014963 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 271848014964 HlyD family secretion protein; Region: HlyD_3; pfam13437 271848014965 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 271848014966 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 271848014967 dimer interface [polypeptide binding]; other site 271848014968 putative CheW interface [polypeptide binding]; other site 271848014969 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848014970 Major Facilitator Superfamily; Region: MFS_1; pfam07690 271848014971 putative substrate translocation pore; other site 271848014972 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 271848014973 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 271848014974 Part of AAA domain; Region: AAA_19; pfam13245 271848014975 Family description; Region: UvrD_C_2; pfam13538 271848014976 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 271848014977 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 271848014978 HIGH motif; other site 271848014979 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 271848014980 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 271848014981 active site 271848014982 KMSKS motif; other site 271848014983 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 271848014984 tRNA binding surface [nucleotide binding]; other site 271848014985 anticodon binding site; other site 271848014986 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 271848014987 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 271848014988 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 271848014989 active site 271848014990 tetramer interface; other site 271848014991 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 271848014992 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 271848014993 CHASE2 domain; Region: CHASE2; pfam05226 271848014994 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 271848014995 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271848014996 dimer interface [polypeptide binding]; other site 271848014997 phosphorylation site [posttranslational modification] 271848014998 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848014999 ATP binding site [chemical binding]; other site 271848015000 Mg2+ binding site [ion binding]; other site 271848015001 G-X-G motif; other site 271848015002 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4254 271848015003 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 271848015004 FecR protein; Region: FecR; pfam04773 271848015005 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 271848015006 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848015007 active site 271848015008 phosphorylation site [posttranslational modification] 271848015009 intermolecular recognition site; other site 271848015010 dimerization interface [polypeptide binding]; other site 271848015011 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 271848015012 DNA binding site [nucleotide binding] 271848015013 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 271848015014 CPxP motif; other site 271848015015 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 271848015016 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 271848015017 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 271848015018 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 271848015019 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 271848015020 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 271848015021 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 271848015022 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 271848015023 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 271848015024 putative active site [active] 271848015025 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 271848015026 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 271848015027 putative ligand binding site [chemical binding]; other site 271848015028 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 271848015029 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 271848015030 TM-ABC transporter signature motif; other site 271848015031 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 271848015032 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 271848015033 Walker A/P-loop; other site 271848015034 ATP binding site [chemical binding]; other site 271848015035 Q-loop/lid; other site 271848015036 ABC transporter signature motif; other site 271848015037 Walker B; other site 271848015038 D-loop; other site 271848015039 H-loop/switch region; other site 271848015040 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 271848015041 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 271848015042 substrate binding site [chemical binding]; other site 271848015043 ATP binding site [chemical binding]; other site 271848015044 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 271848015045 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 271848015046 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 271848015047 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 271848015048 PYR/PP interface [polypeptide binding]; other site 271848015049 dimer interface [polypeptide binding]; other site 271848015050 TPP binding site [chemical binding]; other site 271848015051 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 271848015052 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 271848015053 TPP-binding site [chemical binding]; other site 271848015054 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 271848015055 KduI/IolB family; Region: KduI; pfam04962 271848015056 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 271848015057 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 271848015058 Walker A/P-loop; other site 271848015059 ATP binding site [chemical binding]; other site 271848015060 Q-loop/lid; other site 271848015061 ABC transporter signature motif; other site 271848015062 Walker B; other site 271848015063 D-loop; other site 271848015064 H-loop/switch region; other site 271848015065 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 271848015066 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 271848015067 TM-ABC transporter signature motif; other site 271848015068 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 271848015069 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 271848015070 Walker A/P-loop; other site 271848015071 ATP binding site [chemical binding]; other site 271848015072 Q-loop/lid; other site 271848015073 ABC transporter signature motif; other site 271848015074 Walker B; other site 271848015075 D-loop; other site 271848015076 H-loop/switch region; other site 271848015077 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 271848015078 TM-ABC transporter signature motif; other site 271848015079 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 271848015080 active site 271848015081 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 271848015082 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 271848015083 putative active site [active] 271848015084 metal binding site [ion binding]; metal-binding site 271848015085 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 271848015086 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 271848015087 nudix motif; other site 271848015088 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 271848015089 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 271848015090 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 271848015091 protein binding site [polypeptide binding]; other site 271848015092 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 271848015093 protein binding site [polypeptide binding]; other site 271848015094 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 271848015095 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848015096 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848015097 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848015098 dimerization interface [polypeptide binding]; other site 271848015099 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 271848015100 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 271848015101 motif 1; other site 271848015102 active site 271848015103 motif 2; other site 271848015104 motif 3; other site 271848015105 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 271848015106 DHHA1 domain; Region: DHHA1; pfam02272 271848015107 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 271848015108 CoA-transferase family III; Region: CoA_transf_3; pfam02515 271848015109 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 271848015110 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 271848015111 active site 271848015112 HIGH motif; other site 271848015113 nucleotide binding site [chemical binding]; other site 271848015114 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 271848015115 KMSKS motif; other site 271848015116 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 271848015117 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 271848015118 nudix motif; other site 271848015119 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 271848015120 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 271848015121 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 271848015122 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 271848015123 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 271848015124 acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397 271848015125 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 271848015126 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 271848015127 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 271848015128 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 271848015129 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 271848015130 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848015131 S-adenosylmethionine binding site [chemical binding]; other site 271848015132 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 271848015133 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848015134 active site 271848015135 phosphorylation site [posttranslational modification] 271848015136 intermolecular recognition site; other site 271848015137 dimerization interface [polypeptide binding]; other site 271848015138 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 271848015139 DNA binding residues [nucleotide binding] 271848015140 dimerization interface [polypeptide binding]; other site 271848015141 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271848015142 dimer interface [polypeptide binding]; other site 271848015143 phosphorylation site [posttranslational modification] 271848015144 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848015145 ATP binding site [chemical binding]; other site 271848015146 Mg2+ binding site [ion binding]; other site 271848015147 G-X-G motif; other site 271848015148 Response regulator receiver domain; Region: Response_reg; pfam00072 271848015149 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848015150 active site 271848015151 phosphorylation site [posttranslational modification] 271848015152 intermolecular recognition site; other site 271848015153 dimerization interface [polypeptide binding]; other site 271848015154 Spore Coat Protein U domain; Region: SCPU; pfam05229 271848015155 Spore Coat Protein U domain; Region: SCPU; pfam05229 271848015156 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 271848015157 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 271848015158 PapC C-terminal domain; Region: PapC_C; pfam13953 271848015159 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 271848015160 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 271848015161 Spore Coat Protein U domain; Region: SCPU; pfam05229 271848015162 Spore Coat Protein U domain; Region: SCPU; pfam05229 271848015163 Spore Coat Protein U domain; Region: SCPU; pfam05229 271848015164 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 271848015165 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848015166 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 271848015167 dimerization interface [polypeptide binding]; other site 271848015168 substrate binding pocket [chemical binding]; other site 271848015169 benzoate transport; Region: 2A0115; TIGR00895 271848015170 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848015171 putative substrate translocation pore; other site 271848015172 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 271848015173 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 271848015174 active site 271848015175 H-NS histone family; Region: Histone_HNS; pfam00816 271848015176 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 271848015177 manganese transport protein MntH; Reviewed; Region: PRK00701 271848015178 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 271848015179 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 271848015180 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 271848015181 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 271848015182 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 271848015183 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 271848015184 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 271848015185 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 271848015186 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 271848015187 Transposase; Region: HTH_Tnp_1; pfam01527 271848015188 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 271848015189 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 271848015190 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 271848015191 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 271848015192 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 271848015193 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 271848015194 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 271848015195 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 271848015196 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 271848015197 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 271848015198 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 271848015199 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 271848015200 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 271848015201 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 271848015202 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 271848015203 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 271848015204 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 271848015205 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 271848015206 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 271848015207 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 271848015208 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 271848015209 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 271848015210 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 271848015211 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 271848015212 PAAR motif; Region: PAAR_motif; pfam05488 271848015213 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 271848015214 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 271848015215 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 271848015216 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 271848015217 Interdomain contacts; other site 271848015218 Cytokine receptor motif; other site 271848015219 H-NS histone family; Region: Histone_HNS; pfam00816 271848015220 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 271848015221 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848015222 metabolite-proton symporter; Region: 2A0106; TIGR00883 271848015223 putative substrate translocation pore; other site 271848015224 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 271848015225 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848015226 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848015227 dimerization interface [polypeptide binding]; other site 271848015228 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 271848015229 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 271848015230 active site 271848015231 DNA binding site [nucleotide binding] 271848015232 Int/Topo IB signature motif; other site 271848015233 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 271848015234 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 271848015235 Coenzyme A binding pocket [chemical binding]; other site 271848015236 Part of AAA domain; Region: AAA_19; pfam13245 271848015237 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 271848015238 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 271848015239 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 271848015240 putative active site [active] 271848015241 putative metal-binding site [ion binding]; other site 271848015242 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 271848015243 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 271848015244 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 271848015245 haemagglutination activity domain; Region: Haemagg_act; pfam05860 271848015246 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 271848015247 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 271848015248 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 271848015249 phage/plasmid-like protein TIGR03299; Region: LGT_TIGR03299 271848015250 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 271848015251 Methyltransferase domain; Region: Methyltransf_27; pfam13708 271848015252 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 271848015253 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 271848015254 non-specific DNA binding site [nucleotide binding]; other site 271848015255 salt bridge; other site 271848015256 sequence-specific DNA binding site [nucleotide binding]; other site 271848015257 Methyltransferase domain; Region: Methyltransf_23; pfam13489 271848015258 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848015259 S-adenosylmethionine binding site [chemical binding]; other site 271848015260 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 271848015261 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 271848015262 non-specific DNA binding site [nucleotide binding]; other site 271848015263 salt bridge; other site 271848015264 sequence-specific DNA binding site [nucleotide binding]; other site 271848015265 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 271848015266 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 271848015267 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 271848015268 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 271848015269 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 271848015270 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 271848015271 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 271848015272 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 271848015273 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 271848015274 Transposase; Region: HTH_Tnp_1; pfam01527 271848015275 T5orf172 domain; Region: T5orf172; pfam10544 271848015276 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848015277 ATP binding site [chemical binding]; other site 271848015278 Mg2+ binding site [ion binding]; other site 271848015279 G-X-G motif; other site 271848015280 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 271848015281 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 271848015282 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 271848015283 ATP binding site [chemical binding]; other site 271848015284 putative Mg++ binding site [ion binding]; other site 271848015285 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 271848015286 Abortive infection C-terminus; Region: Abi_C; pfam14355 271848015287 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 271848015288 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 271848015289 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 271848015290 HsdM N-terminal domain; Region: HsdM_N; pfam12161 271848015291 Methyltransferase domain; Region: Methyltransf_26; pfam13659 271848015292 IS2 transposase TnpB; Reviewed; Region: PRK09409 271848015293 HTH-like domain; Region: HTH_21; pfam13276 271848015294 Integrase core domain; Region: rve; pfam00665 271848015295 Integrase core domain; Region: rve_3; pfam13683 271848015296 Transposase; Region: HTH_Tnp_1; cl17663 271848015297 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 271848015298 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 271848015299 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 271848015300 catalytic residues [active] 271848015301 catalytic nucleophile [active] 271848015302 Recombinase; Region: Recombinase; pfam07508 271848015303 ParB-like nuclease domain; Region: ParB; smart00470 271848015304 Transposase, Mutator family; Region: Transposase_mut; pfam00872 271848015305 MULE transposase domain; Region: MULE; pfam10551 271848015306 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 271848015307 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 271848015308 active site 271848015309 catalytic residues [active] 271848015310 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 271848015311 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 271848015312 Peptidase family M23; Region: Peptidase_M23; pfam01551 271848015313 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 271848015314 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_3; cd05971 271848015315 active site 271848015316 acyl-activating enzyme (AAE) consensus motif; other site 271848015317 putative CoA binding site [chemical binding]; other site 271848015318 AMP binding site [chemical binding]; other site 271848015319 Protein of unknown function (DUF2288); Region: DUF2288; pfam10052 271848015320 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 271848015321 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 271848015322 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 271848015323 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 271848015324 catalytic core [active] 271848015325 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 271848015326 active site 271848015327 Sec24-related protein; Provisional; Region: PTZ00395 271848015328 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 271848015329 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 271848015330 polyphosphate kinase; Provisional; Region: PRK05443 271848015331 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 271848015332 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 271848015333 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 271848015334 putative active site [active] 271848015335 catalytic site [active] 271848015336 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 271848015337 putative domain interface [polypeptide binding]; other site 271848015338 putative active site [active] 271848015339 catalytic site [active] 271848015340 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 271848015341 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 271848015342 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271848015343 dimer interface [polypeptide binding]; other site 271848015344 phosphorylation site [posttranslational modification] 271848015345 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848015346 ATP binding site [chemical binding]; other site 271848015347 Mg2+ binding site [ion binding]; other site 271848015348 G-X-G motif; other site 271848015349 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 271848015350 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848015351 active site 271848015352 phosphorylation site [posttranslational modification] 271848015353 intermolecular recognition site; other site 271848015354 dimerization interface [polypeptide binding]; other site 271848015355 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 271848015356 DNA binding site [nucleotide binding] 271848015357 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 271848015358 PhoU domain; Region: PhoU; pfam01895 271848015359 PhoU domain; Region: PhoU; pfam01895 271848015360 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 271848015361 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 271848015362 Walker A/P-loop; other site 271848015363 ATP binding site [chemical binding]; other site 271848015364 Q-loop/lid; other site 271848015365 ABC transporter signature motif; other site 271848015366 Walker B; other site 271848015367 D-loop; other site 271848015368 H-loop/switch region; other site 271848015369 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 271848015370 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848015371 dimer interface [polypeptide binding]; other site 271848015372 conserved gate region; other site 271848015373 putative PBP binding loops; other site 271848015374 ABC-ATPase subunit interface; other site 271848015375 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 271848015376 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848015377 dimer interface [polypeptide binding]; other site 271848015378 conserved gate region; other site 271848015379 putative PBP binding loops; other site 271848015380 ABC-ATPase subunit interface; other site 271848015381 PBP superfamily domain; Region: PBP_like_2; cl17296 271848015382 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 271848015383 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 271848015384 active site 271848015385 substrate binding site [chemical binding]; other site 271848015386 metal binding site [ion binding]; metal-binding site 271848015387 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 271848015388 dihydropteroate synthase; Region: DHPS; TIGR01496 271848015389 substrate binding pocket [chemical binding]; other site 271848015390 dimer interface [polypeptide binding]; other site 271848015391 inhibitor binding site; inhibition site 271848015392 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 271848015393 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848015394 Walker A motif; other site 271848015395 ATP binding site [chemical binding]; other site 271848015396 Walker B motif; other site 271848015397 arginine finger; other site 271848015398 Peptidase family M41; Region: Peptidase_M41; pfam01434 271848015399 FtsJ-like methyltransferase; Region: FtsJ; cl17430 271848015400 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 271848015401 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 271848015402 Domain of unknown function (DUF4149); Region: DUF4149; pfam13664 271848015403 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 271848015404 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 271848015405 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 271848015406 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 271848015407 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 271848015408 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 271848015409 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 271848015410 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 271848015411 ATP-grasp domain; Region: ATP-grasp_4; cl17255 271848015412 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 271848015413 IMP binding site; other site 271848015414 dimer interface [polypeptide binding]; other site 271848015415 interdomain contacts; other site 271848015416 partial ornithine binding site; other site 271848015417 leucine export protein LeuE; Provisional; Region: PRK10958 271848015418 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 271848015419 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 271848015420 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 271848015421 catalytic site [active] 271848015422 subunit interface [polypeptide binding]; other site 271848015423 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 271848015424 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 271848015425 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848015426 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848015427 putative substrate translocation pore; other site 271848015428 Major Facilitator Superfamily; Region: MFS_1; pfam07690 271848015429 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 271848015430 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 271848015431 N-acetyl-D-glucosamine binding site [chemical binding]; other site 271848015432 catalytic residue [active] 271848015433 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 271848015434 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 271848015435 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 271848015436 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848015437 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 271848015438 RNA/DNA hybrid binding site [nucleotide binding]; other site 271848015439 active site 271848015440 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 271848015441 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 271848015442 active site 271848015443 catalytic site [active] 271848015444 substrate binding site [chemical binding]; other site 271848015445 hypothetical protein; Provisional; Region: PRK02237 271848015446 proline/glycine betaine transporter; Provisional; Region: PRK10642 271848015447 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848015448 putative substrate translocation pore; other site 271848015449 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 271848015450 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 271848015451 C-terminal domain interface [polypeptide binding]; other site 271848015452 GSH binding site (G-site) [chemical binding]; other site 271848015453 dimer interface [polypeptide binding]; other site 271848015454 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 271848015455 N-terminal domain interface [polypeptide binding]; other site 271848015456 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 271848015457 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 271848015458 putative active site [active] 271848015459 catalytic site [active] 271848015460 Acyl transferase domain; Region: Acyl_transf_1; cl08282 271848015461 triphosphoribosyl-dephospho-CoA synthase MdcB; Region: malonate_mdcB; TIGR03132 271848015462 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK02098 271848015463 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 271848015464 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293; cl07913 271848015465 malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134 271848015466 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 271848015467 malonate decarboxylase subunit delta; Provisional; Region: PRK02103 271848015468 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 271848015469 Malonate/sodium symporter MadM subunit; Region: MadM; cl04274 271848015470 Malonate transporter MadL subunit; Region: MadL; cl04273 271848015471 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848015472 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848015473 dimerization interface [polypeptide binding]; other site 271848015474 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 271848015475 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 271848015476 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 271848015477 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 271848015478 active site 271848015479 substrate-binding site [chemical binding]; other site 271848015480 metal-binding site [ion binding] 271848015481 GTP binding site [chemical binding]; other site 271848015482 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 271848015483 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 271848015484 putative dimer interface [polypeptide binding]; other site 271848015485 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 271848015486 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 271848015487 putative dimer interface [polypeptide binding]; other site 271848015488 GSCFA family; Region: GSCFA; pfam08885 271848015489 Methyltransferase domain; Region: Methyltransf_23; pfam13489 271848015490 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 271848015491 Uncharacterized protein conserved in bacteria (DUF2242); Region: DUF2242; pfam10001 271848015492 short chain dehydrogenase; Provisional; Region: PRK12744 271848015493 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 271848015494 NAD(P) binding site [chemical binding]; other site 271848015495 active site 271848015496 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848015497 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848015498 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 271848015499 putative effector binding pocket; other site 271848015500 putative dimerization interface [polypeptide binding]; other site 271848015501 Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998 271848015502 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 271848015503 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 271848015504 Predicted metal-binding integral membrane protein [Function unknown]; Region: COG5486 271848015505 Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948 271848015506 Protein of unknown function (DUF1326); Region: DUF1326; pfam07040 271848015507 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848015508 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 271848015509 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271848015510 metal binding site [ion binding]; metal-binding site 271848015511 active site 271848015512 I-site; other site 271848015513 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 271848015514 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 271848015515 trimer interface [polypeptide binding]; other site 271848015516 eyelet of channel; other site 271848015517 Transcriptional regulators [Transcription]; Region: PurR; COG1609 271848015518 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 271848015519 DNA binding site [nucleotide binding] 271848015520 domain linker motif; other site 271848015521 Ligand-binding domain of putative DNA transcription repressors highly similar to that of the repressor specific for gluconate (GntR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_2; cd06282 271848015522 putative dimerization interface [polypeptide binding]; other site 271848015523 putative ligand binding site [chemical binding]; other site 271848015524 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 271848015525 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 271848015526 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 271848015527 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 271848015528 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848015529 putative PBP binding loops; other site 271848015530 ABC-ATPase subunit interface; other site 271848015531 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 271848015532 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 271848015533 Walker A/P-loop; other site 271848015534 ATP binding site [chemical binding]; other site 271848015535 Q-loop/lid; other site 271848015536 ABC transporter signature motif; other site 271848015537 Walker B; other site 271848015538 D-loop; other site 271848015539 H-loop/switch region; other site 271848015540 TOBE domain; Region: TOBE_2; pfam08402 271848015541 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 271848015542 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 271848015543 active site 271848015544 metal binding site [ion binding]; metal-binding site 271848015545 hexamer interface [polypeptide binding]; other site 271848015546 Transposase; Region: DEDD_Tnp_IS110; pfam01548 271848015547 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 271848015548 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848015549 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 271848015550 EamA-like transporter family; Region: EamA; pfam00892 271848015551 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 271848015552 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 271848015553 Moco binding site; other site 271848015554 metal coordination site [ion binding]; other site 271848015555 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 271848015556 Protein of unknown function (DUF1223); Region: DUF1223; cl10501 271848015557 pentapeptide MXKDX repeat protein; Region: penta_MxKDx; TIGR02953 271848015558 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 271848015559 ThiC-associated domain; Region: ThiC-associated; pfam13667 271848015560 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 271848015561 EamA-like transporter family; Region: EamA; pfam00892 271848015562 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 271848015563 EamA-like transporter family; Region: EamA; pfam00892 271848015564 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 271848015565 hypothetical protein; Provisional; Region: PRK09256 271848015566 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 271848015567 AAA domain; Region: AAA_30; pfam13604 271848015568 Family description; Region: UvrD_C_2; pfam13538 271848015569 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 271848015570 Family description; Region: UvrD_C_2; pfam13538 271848015571 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 271848015572 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 271848015573 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 271848015574 Predicted membrane protein [Function unknown]; Region: COG1289 271848015575 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 271848015576 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 271848015577 putative proline-specific permease; Provisional; Region: proY; PRK10580 271848015578 Spore germination protein; Region: Spore_permease; cl17796 271848015579 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 271848015580 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 271848015581 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 271848015582 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848015583 dimer interface [polypeptide binding]; other site 271848015584 conserved gate region; other site 271848015585 putative PBP binding loops; other site 271848015586 ABC-ATPase subunit interface; other site 271848015587 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 271848015588 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848015589 ABC-ATPase subunit interface; other site 271848015590 putative PBP binding loops; other site 271848015591 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 271848015592 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 271848015593 Walker A/P-loop; other site 271848015594 ATP binding site [chemical binding]; other site 271848015595 Q-loop/lid; other site 271848015596 ABC transporter signature motif; other site 271848015597 Walker B; other site 271848015598 D-loop; other site 271848015599 H-loop/switch region; other site 271848015600 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 271848015601 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 271848015602 putative DNA binding site [nucleotide binding]; other site 271848015603 putative Zn2+ binding site [ion binding]; other site 271848015604 AsnC family; Region: AsnC_trans_reg; pfam01037 271848015605 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 271848015606 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 271848015607 NADH(P)-binding; Region: NAD_binding_10; pfam13460 271848015608 NAD binding site [chemical binding]; other site 271848015609 putative active site [active] 271848015610 substrate binding site [chemical binding]; other site 271848015611 Predicted transcriptional regulator [Transcription]; Region: COG1959 271848015612 Transcriptional regulator; Region: Rrf2; pfam02082 271848015613 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 271848015614 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 271848015615 Transcriptional regulator [Transcription]; Region: IclR; COG1414 271848015616 Bacterial transcriptional regulator; Region: IclR; pfam01614 271848015617 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 271848015618 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 271848015619 HlyD family secretion protein; Region: HlyD_3; pfam13437 271848015620 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 271848015621 Protein export membrane protein; Region: SecD_SecF; cl14618 271848015622 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 271848015623 Protein export membrane protein; Region: SecD_SecF; cl14618 271848015624 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 271848015625 NADH(P)-binding; Region: NAD_binding_10; pfam13460 271848015626 NAD(P) binding site [chemical binding]; other site 271848015627 putative active site [active] 271848015628 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 271848015629 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 271848015630 catalytic triad [active] 271848015631 PAS domain; Region: PAS_9; pfam13426 271848015632 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 271848015633 putative active site [active] 271848015634 heme pocket [chemical binding]; other site 271848015635 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 271848015636 metal binding site [ion binding]; metal-binding site 271848015637 active site 271848015638 I-site; other site 271848015639 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 271848015640 HDOD domain; Region: HDOD; pfam08668 271848015641 Cytochrome c553 [Energy production and conversion]; Region: COG2863 271848015642 Cytochrome c; Region: Cytochrom_C; cl11414 271848015643 ba3-like heme-copper oxidase subunit I. The ba3 family of heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and some archaea which catalyze the reduction of O2 and simultaneously pump protons across the...; Region: ba3-like_Oxidase_I; cd01660 271848015644 Low-spin heme binding site [chemical binding]; other site 271848015645 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 271848015646 Subunit I/II interface [polypeptide binding]; other site 271848015647 Putative Q-pathway; other site 271848015648 Putative D-pathway homolog; other site 271848015649 Putative alternate electron transfer pathway; other site 271848015650 Putative water exit pathway; other site 271848015651 Binuclear center (active site) [active] 271848015652 Putative K-pathway homolog; other site 271848015653 Putative proton exit pathway; other site 271848015654 Subunit I/IIa interface [polypeptide binding]; other site 271848015655 Electron transfer pathway; other site 271848015656 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 271848015657 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 271848015658 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 271848015659 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 271848015660 Cytochrome c; Region: Cytochrom_C; pfam00034 271848015661 Cytochrome c; Region: Cytochrom_C; cl11414 271848015662 Cytochrome c; Region: Cytochrom_C; cl11414 271848015663 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 271848015664 catalytic motif [active] 271848015665 Catalytic residue [active] 271848015666 Aspartyl protease; Region: Asp_protease_2; pfam13650 271848015667 inhibitor binding site; inhibition site 271848015668 catalytic motif [active] 271848015669 Catalytic residue [active] 271848015670 Active site flap [active] 271848015671 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 271848015672 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 271848015673 Histidine kinase; Region: HisKA_3; pfam07730 271848015674 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848015675 ATP binding site [chemical binding]; other site 271848015676 Mg2+ binding site [ion binding]; other site 271848015677 G-X-G motif; other site 271848015678 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 271848015679 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 271848015680 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 271848015681 ligand binding site [chemical binding]; other site 271848015682 NAD binding site [chemical binding]; other site 271848015683 tetramer interface [polypeptide binding]; other site 271848015684 catalytic site [active] 271848015685 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 271848015686 L-serine binding site [chemical binding]; other site 271848015687 ACT domain interface; other site 271848015688 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 271848015689 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 271848015690 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848015691 Fatty acid desaturase; Region: FA_desaturase; pfam00487 271848015692 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 271848015693 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 271848015694 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 271848015695 active site 271848015696 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 271848015697 Transposase; Region: HTH_Tnp_1; pfam01527 271848015698 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 271848015699 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 271848015700 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 271848015701 Transposase, Mutator family; Region: Transposase_mut; pfam00872 271848015702 MULE transposase domain; Region: MULE; pfam10551 271848015703 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 271848015704 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 271848015705 enoyl-CoA hydratase; Provisional; Region: PRK05862 271848015706 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 271848015707 substrate binding site [chemical binding]; other site 271848015708 oxyanion hole (OAH) forming residues; other site 271848015709 trimer interface [polypeptide binding]; other site 271848015710 phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288 271848015711 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 271848015712 NAD(P) binding site [chemical binding]; other site 271848015713 catalytic residues [active] 271848015714 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 271848015715 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 271848015716 dimer interface [polypeptide binding]; other site 271848015717 active site 271848015718 enoyl-CoA hydratase; Provisional; Region: PRK08140 271848015719 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 271848015720 substrate binding site [chemical binding]; other site 271848015721 oxyanion hole (OAH) forming residues; other site 271848015722 trimer interface [polypeptide binding]; other site 271848015723 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 271848015724 CoenzymeA binding site [chemical binding]; other site 271848015725 subunit interaction site [polypeptide binding]; other site 271848015726 PHB binding site; other site 271848015727 Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913 271848015728 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 271848015729 active site 271848015730 AMP binding site [chemical binding]; other site 271848015731 homodimer interface [polypeptide binding]; other site 271848015732 acyl-activating enzyme (AAE) consensus motif; other site 271848015733 CoA binding site [chemical binding]; other site 271848015734 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 271848015735 MltA specific insert domain; Region: MltA; smart00925 271848015736 3D domain; Region: 3D; pfam06725 271848015737 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 271848015738 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 271848015739 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 271848015740 substrate binding site [chemical binding]; other site 271848015741 hexamer interface [polypeptide binding]; other site 271848015742 metal binding site [ion binding]; metal-binding site 271848015743 phosphoglycolate phosphatase; Provisional; Region: PRK13222 271848015744 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 271848015745 motif II; other site 271848015746 anthranilate synthase component I; Provisional; Region: PRK13565 271848015747 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 271848015748 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 271848015749 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 271848015750 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 271848015751 glutamine binding [chemical binding]; other site 271848015752 catalytic triad [active] 271848015753 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 271848015754 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 271848015755 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 271848015756 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 271848015757 active site 271848015758 ribulose/triose binding site [chemical binding]; other site 271848015759 phosphate binding site [ion binding]; other site 271848015760 substrate (anthranilate) binding pocket [chemical binding]; other site 271848015761 product (indole) binding pocket [chemical binding]; other site 271848015762 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 271848015763 putative active site [active] 271848015764 putative metal binding residues [ion binding]; other site 271848015765 signature motif; other site 271848015766 putative triphosphate binding site [ion binding]; other site 271848015767 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 271848015768 ligand binding site [chemical binding]; other site 271848015769 active site 271848015770 UGI interface [polypeptide binding]; other site 271848015771 catalytic site [active] 271848015772 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 271848015773 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 271848015774 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 271848015775 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 271848015776 PDZ domain; Region: PDZ_2; pfam13180 271848015777 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 271848015778 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 271848015779 dimerization domain [polypeptide binding]; other site 271848015780 dimer interface [polypeptide binding]; other site 271848015781 catalytic residues [active] 271848015782 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608 271848015783 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 271848015784 GTP-binding protein YchF; Reviewed; Region: PRK09601 271848015785 YchF GTPase; Region: YchF; cd01900 271848015786 G1 box; other site 271848015787 GTP/Mg2+ binding site [chemical binding]; other site 271848015788 Switch I region; other site 271848015789 G2 box; other site 271848015790 Switch II region; other site 271848015791 G3 box; other site 271848015792 G4 box; other site 271848015793 G5 box; other site 271848015794 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 271848015795 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 271848015796 Protein of unknown function (DUF419); Region: DUF419; cl15265 271848015797 Protein of unknown function (DUF3761); Region: DUF3761; pfam12587 271848015798 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 271848015799 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 271848015800 Walker A/P-loop; other site 271848015801 ATP binding site [chemical binding]; other site 271848015802 Q-loop/lid; other site 271848015803 ABC transporter signature motif; other site 271848015804 Walker B; other site 271848015805 D-loop; other site 271848015806 H-loop/switch region; other site 271848015807 ABC transporter; Region: ABC_tran_2; pfam12848 271848015808 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 271848015809 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 271848015810 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 271848015811 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 271848015812 Isochorismatase family; Region: Isochorismatase; pfam00857 271848015813 catalytic triad [active] 271848015814 conserved cis-peptide bond; other site 271848015815 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 271848015816 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 271848015817 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 271848015818 active site 271848015819 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 271848015820 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 271848015821 tRNA; other site 271848015822 putative tRNA binding site [nucleotide binding]; other site 271848015823 putative NADP binding site [chemical binding]; other site 271848015824 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 271848015825 peptide chain release factor 1; Validated; Region: prfA; PRK00591 271848015826 This domain is found in peptide chain release factors; Region: PCRF; smart00937 271848015827 RF-1 domain; Region: RF-1; pfam00472 271848015828 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 271848015829 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848015830 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 271848015831 putative GSH binding site [chemical binding]; other site 271848015832 catalytic residues [active] 271848015833 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 271848015834 Flavoprotein; Region: Flavoprotein; pfam02441 271848015835 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 271848015836 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 271848015837 putative active site [active] 271848015838 metal binding site [ion binding]; metal-binding site 271848015839 amino acid transporter; Region: 2A0306; TIGR00909 271848015840 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 271848015841 DNA-binding site [nucleotide binding]; DNA binding site 271848015842 RNA-binding motif; other site 271848015843 putative chaperone; Provisional; Region: PRK11678 271848015844 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 271848015845 nucleotide binding site [chemical binding]; other site 271848015846 putative NEF/HSP70 interaction site [polypeptide binding]; other site 271848015847 SBD interface [polypeptide binding]; other site 271848015848 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 271848015849 putative FMN binding site [chemical binding]; other site 271848015850 D-galactonate transporter; Region: 2A0114; TIGR00893 271848015851 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848015852 putative substrate translocation pore; other site 271848015853 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 271848015854 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 271848015855 Protein of unknown function (DUF1415); Region: DUF1415; pfam07209 271848015856 Methyltransferase domain; Region: Methyltransf_32; pfam13679 271848015857 Methyltransferase domain; Region: Methyltransf_31; pfam13847 271848015858 Methyltransferase domain; Region: Methyltransf_23; pfam13489 271848015859 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848015860 S-adenosylmethionine binding site [chemical binding]; other site 271848015861 Water Stress and Hypersensitive response; Region: WHy; smart00769 271848015862 Peptidase family M1; Region: Peptidase_M1; pfam01433 271848015863 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 271848015864 Zn binding site [ion binding]; other site 271848015865 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 271848015866 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 271848015867 HlyD family secretion protein; Region: HlyD_3; pfam13437 271848015868 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 271848015869 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 271848015870 putative active site [active] 271848015871 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 271848015872 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 271848015873 Walker A/P-loop; other site 271848015874 ATP binding site [chemical binding]; other site 271848015875 Q-loop/lid; other site 271848015876 ABC transporter signature motif; other site 271848015877 Walker B; other site 271848015878 D-loop; other site 271848015879 H-loop/switch region; other site 271848015880 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 271848015881 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 271848015882 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 271848015883 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 271848015884 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 271848015885 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 271848015886 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 271848015887 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611 271848015888 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 271848015889 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 271848015890 ligand binding site [chemical binding]; other site 271848015891 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 271848015892 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 271848015893 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 271848015894 Clp amino terminal domain; Region: Clp_N; pfam02861 271848015895 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848015896 Walker A motif; other site 271848015897 ATP binding site [chemical binding]; other site 271848015898 Walker B motif; other site 271848015899 arginine finger; other site 271848015900 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848015901 Walker A motif; other site 271848015902 ATP binding site [chemical binding]; other site 271848015903 Walker B motif; other site 271848015904 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 271848015905 type VI secretion protein, VC_A0111 family; Region: VI_chp_1; TIGR03347 271848015906 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 271848015907 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 271848015908 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3518 271848015909 Protein of unknown function (DUF796); Region: DUF796; pfam05638 271848015910 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 271848015911 Protein of unknown function (DUF877); Region: DUF877; pfam05943 271848015912 Protein of unknown function (DUF770); Region: DUF770; pfam05591 271848015913 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 271848015914 TPR motif; other site 271848015915 binding surface 271848015916 type VI secretion lipoprotein, VC_A0113 family; Region: VI_chp_3; TIGR03352 271848015917 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 271848015918 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 271848015919 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 271848015920 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 271848015921 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 271848015922 stringent starvation protein A; Provisional; Region: sspA; PRK09481 271848015923 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 271848015924 C-terminal domain interface [polypeptide binding]; other site 271848015925 putative GSH binding site (G-site) [chemical binding]; other site 271848015926 dimer interface [polypeptide binding]; other site 271848015927 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 271848015928 dimer interface [polypeptide binding]; other site 271848015929 N-terminal domain interface [polypeptide binding]; other site 271848015930 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 271848015931 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 271848015932 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 271848015933 Qi binding site; other site 271848015934 intrachain domain interface; other site 271848015935 interchain domain interface [polypeptide binding]; other site 271848015936 heme bH binding site [chemical binding]; other site 271848015937 heme bL binding site [chemical binding]; other site 271848015938 Qo binding site; other site 271848015939 interchain domain interface [polypeptide binding]; other site 271848015940 intrachain domain interface; other site 271848015941 Qi binding site; other site 271848015942 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 271848015943 Qo binding site; other site 271848015944 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 271848015945 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 271848015946 [2Fe-2S] cluster binding site [ion binding]; other site 271848015947 Uncharacterized conserved protein [Function unknown]; Region: COG0327 271848015948 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 271848015949 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 271848015950 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 271848015951 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 271848015952 protein binding site [polypeptide binding]; other site 271848015953 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 271848015954 sec-independent translocase; Provisional; Region: tatB; PRK01919 271848015955 twin arginine translocase protein A; Provisional; Region: tatA; PRK02958 271848015956 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 271848015957 nucleotide binding site/active site [active] 271848015958 HIT family signature motif; other site 271848015959 catalytic residue [active] 271848015960 Predicted membrane protein [Function unknown]; Region: COG3671 271848015961 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 271848015962 metal binding site [ion binding]; metal-binding site 271848015963 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 271848015964 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 271848015965 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 271848015966 substrate binding site [chemical binding]; other site 271848015967 glutamase interaction surface [polypeptide binding]; other site 271848015968 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 271848015969 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 271848015970 catalytic residues [active] 271848015971 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 271848015972 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 271848015973 putative active site [active] 271848015974 oxyanion strand; other site 271848015975 catalytic triad [active] 271848015976 MarC family integral membrane protein; Region: MarC; cl00919 271848015977 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 271848015978 putative active site pocket [active] 271848015979 4-fold oligomerization interface [polypeptide binding]; other site 271848015980 metal binding residues [ion binding]; metal-binding site 271848015981 3-fold/trimer interface [polypeptide binding]; other site 271848015982 histidinol-phosphate aminotransferase; Provisional; Region: PRK04870 271848015983 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 271848015984 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848015985 homodimer interface [polypeptide binding]; other site 271848015986 catalytic residue [active] 271848015987 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 271848015988 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 271848015989 NAD binding site [chemical binding]; other site 271848015990 dimerization interface [polypeptide binding]; other site 271848015991 product binding site; other site 271848015992 substrate binding site [chemical binding]; other site 271848015993 zinc binding site [ion binding]; other site 271848015994 catalytic residues [active] 271848015995 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 271848015996 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 271848015997 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 271848015998 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 271848015999 hinge; other site 271848016000 active site 271848016001 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 271848016002 ABC-2 type transporter; Region: ABC2_membrane; cl17235 271848016003 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 271848016004 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 271848016005 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 271848016006 Walker A/P-loop; other site 271848016007 ATP binding site [chemical binding]; other site 271848016008 Q-loop/lid; other site 271848016009 ABC transporter signature motif; other site 271848016010 Walker B; other site 271848016011 D-loop; other site 271848016012 H-loop/switch region; other site 271848016013 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 271848016014 anti sigma factor interaction site; other site 271848016015 regulatory phosphorylation site [posttranslational modification]; other site 271848016016 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 271848016017 VacJ like lipoprotein; Region: VacJ; cl01073 271848016018 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 271848016019 mce related protein; Region: MCE; pfam02470 271848016020 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 271848016021 Permease; Region: Permease; pfam02405 271848016022 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 271848016023 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 271848016024 Walker A/P-loop; other site 271848016025 ATP binding site [chemical binding]; other site 271848016026 Q-loop/lid; other site 271848016027 ABC transporter signature motif; other site 271848016028 Walker B; other site 271848016029 D-loop; other site 271848016030 H-loop/switch region; other site 271848016031 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 271848016032 thiamine phosphate binding site [chemical binding]; other site 271848016033 active site 271848016034 pyrophosphate binding site [ion binding]; other site 271848016035 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 271848016036 ThiS interaction site; other site 271848016037 putative active site [active] 271848016038 tetramer interface [polypeptide binding]; other site 271848016039 sulfur carrier protein ThiS; Provisional; Region: PRK06944 271848016040 charged pocket; other site 271848016041 hydrophobic patch; other site 271848016042 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 271848016043 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 271848016044 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 271848016045 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 271848016046 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 271848016047 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 271848016048 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 271848016049 amino acid carrier protein; Region: agcS; TIGR00835 271848016050 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 271848016051 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 271848016052 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 271848016053 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 271848016054 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 271848016055 active site 271848016056 dimer interface [polypeptide binding]; other site 271848016057 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 271848016058 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 271848016059 active site 271848016060 FMN binding site [chemical binding]; other site 271848016061 substrate binding site [chemical binding]; other site 271848016062 3Fe-4S cluster binding site [ion binding]; other site 271848016063 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 271848016064 domain interface; other site 271848016065 Transposase IS200 like; Region: Y1_Tnp; cl00848 271848016066 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 271848016067 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 271848016068 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 271848016069 active site 271848016070 catalytic site [active] 271848016071 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 271848016072 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 271848016073 Walker A/P-loop; other site 271848016074 ATP binding site [chemical binding]; other site 271848016075 Q-loop/lid; other site 271848016076 ABC transporter signature motif; other site 271848016077 Walker B; other site 271848016078 D-loop; other site 271848016079 H-loop/switch region; other site 271848016080 TOBE domain; Region: TOBE_2; pfam08402 271848016081 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 271848016082 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848016083 dimer interface [polypeptide binding]; other site 271848016084 conserved gate region; other site 271848016085 putative PBP binding loops; other site 271848016086 ABC-ATPase subunit interface; other site 271848016087 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 271848016088 dimer interface [polypeptide binding]; other site 271848016089 conserved gate region; other site 271848016090 putative PBP binding loops; other site 271848016091 ABC-ATPase subunit interface; other site 271848016092 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 271848016093 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 271848016094 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 271848016095 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 271848016096 Zn2+ binding site [ion binding]; other site 271848016097 Mg2+ binding site [ion binding]; other site 271848016098 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 271848016099 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 271848016100 active site 271848016101 dimer interface [polypeptide binding]; other site 271848016102 metal binding site [ion binding]; metal-binding site 271848016103 shikimate kinase; Reviewed; Region: aroK; PRK00131 271848016104 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 271848016105 ADP binding site [chemical binding]; other site 271848016106 magnesium binding site [ion binding]; other site 271848016107 putative shikimate binding site; other site 271848016108 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 271848016109 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 271848016110 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 271848016111 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 271848016112 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 271848016113 Transglycosylase; Region: Transgly; pfam00912 271848016114 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 271848016115 frataxin-like protein; Provisional; Region: cyaY; PRK00446 271848016116 putative iron binding site [ion binding]; other site 271848016117 diaminopimelate decarboxylase; Region: lysA; TIGR01048 271848016118 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 271848016119 active site 271848016120 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 271848016121 substrate binding site [chemical binding]; other site 271848016122 catalytic residues [active] 271848016123 dimer interface [polypeptide binding]; other site 271848016124 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 271848016125 TMAO/DMSO reductase; Reviewed; Region: PRK05363 271848016126 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 271848016127 Moco binding site; other site 271848016128 metal coordination site [ion binding]; other site 271848016129 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 271848016130 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 271848016131 ResB-like family; Region: ResB; pfam05140 271848016132 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 271848016133 ResB-like family; Region: ResB; pfam05140 271848016134 Cytochrome c553 [Energy production and conversion]; Region: COG2863 271848016135 Cytochrome c; Region: Cytochrom_C; cl11414 271848016136 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 271848016137 G1 box; other site 271848016138 GTP/Mg2+ binding site [chemical binding]; other site 271848016139 Switch I region; other site 271848016140 G2 box; other site 271848016141 G3 box; other site 271848016142 Switch II region; other site 271848016143 G4 box; other site 271848016144 G5 box; other site 271848016145 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 271848016146 dimer interface [polypeptide binding]; other site 271848016147 active site 271848016148 aspartate-rich active site metal binding site; other site 271848016149 allosteric magnesium binding site [ion binding]; other site 271848016150 Schiff base residues; other site 271848016151 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 271848016152 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 271848016153 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 271848016154 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 271848016155 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 271848016156 DsbD alpha interface [polypeptide binding]; other site 271848016157 catalytic residues [active] 271848016158 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 271848016159 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 271848016160 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 271848016161 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 271848016162 alphaNTD homodimer interface [polypeptide binding]; other site 271848016163 alphaNTD - beta interaction site [polypeptide binding]; other site 271848016164 alphaNTD - beta' interaction site [polypeptide binding]; other site 271848016165 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 271848016166 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 271848016167 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 271848016168 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 271848016169 RNA binding surface [nucleotide binding]; other site 271848016170 30S ribosomal protein S11; Validated; Region: PRK05309 271848016171 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 271848016172 30S ribosomal protein S13; Region: bact_S13; TIGR03631 271848016173 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 271848016174 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 271848016175 rRNA binding site [nucleotide binding]; other site 271848016176 predicted 30S ribosome binding site; other site 271848016177 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 271848016178 SecY translocase; Region: SecY; pfam00344 271848016179 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 271848016180 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 271848016181 23S rRNA binding site [nucleotide binding]; other site 271848016182 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 271848016183 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 271848016184 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 271848016185 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 271848016186 5S rRNA interface [nucleotide binding]; other site 271848016187 L27 interface [polypeptide binding]; other site 271848016188 23S rRNA interface [nucleotide binding]; other site 271848016189 L5 interface [polypeptide binding]; other site 271848016190 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 271848016191 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 271848016192 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 271848016193 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 271848016194 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 271848016195 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 271848016196 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 271848016197 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 271848016198 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 271848016199 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 271848016200 RNA binding site [nucleotide binding]; other site 271848016201 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 271848016202 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 271848016203 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 271848016204 23S rRNA interface [nucleotide binding]; other site 271848016205 putative translocon interaction site; other site 271848016206 signal recognition particle (SRP54) interaction site; other site 271848016207 L23 interface [polypeptide binding]; other site 271848016208 trigger factor interaction site; other site 271848016209 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 271848016210 23S rRNA interface [nucleotide binding]; other site 271848016211 5S rRNA interface [nucleotide binding]; other site 271848016212 putative antibiotic binding site [chemical binding]; other site 271848016213 L25 interface [polypeptide binding]; other site 271848016214 L27 interface [polypeptide binding]; other site 271848016215 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 271848016216 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 271848016217 G-X-X-G motif; other site 271848016218 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 271848016219 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 271848016220 putative translocon binding site; other site 271848016221 protein-rRNA interface [nucleotide binding]; other site 271848016222 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 271848016223 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 271848016224 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 271848016225 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 271848016226 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 271848016227 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 271848016228 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 271848016229 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 271848016230 elongation factor Tu; Reviewed; Region: PRK00049 271848016231 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 271848016232 G1 box; other site 271848016233 GEF interaction site [polypeptide binding]; other site 271848016234 GTP/Mg2+ binding site [chemical binding]; other site 271848016235 Switch I region; other site 271848016236 G2 box; other site 271848016237 G3 box; other site 271848016238 Switch II region; other site 271848016239 G4 box; other site 271848016240 G5 box; other site 271848016241 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 271848016242 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 271848016243 Antibiotic Binding Site [chemical binding]; other site 271848016244 elongation factor G; Reviewed; Region: PRK00007 271848016245 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 271848016246 G1 box; other site 271848016247 putative GEF interaction site [polypeptide binding]; other site 271848016248 GTP/Mg2+ binding site [chemical binding]; other site 271848016249 Switch I region; other site 271848016250 G2 box; other site 271848016251 G3 box; other site 271848016252 Switch II region; other site 271848016253 G4 box; other site 271848016254 G5 box; other site 271848016255 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 271848016256 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 271848016257 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 271848016258 30S ribosomal protein S7; Validated; Region: PRK05302 271848016259 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 271848016260 S17 interaction site [polypeptide binding]; other site 271848016261 S8 interaction site; other site 271848016262 16S rRNA interaction site [nucleotide binding]; other site 271848016263 streptomycin interaction site [chemical binding]; other site 271848016264 23S rRNA interaction site [nucleotide binding]; other site 271848016265 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 271848016266 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 271848016267 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 271848016268 ATP binding site [chemical binding]; other site 271848016269 putative Mg++ binding site [ion binding]; other site 271848016270 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 271848016271 nucleotide binding region [chemical binding]; other site 271848016272 ATP-binding site [chemical binding]; other site 271848016273 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 271848016274 HRDC domain; Region: HRDC; pfam00570 271848016275 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 271848016276 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 271848016277 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 271848016278 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 271848016279 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 271848016280 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 271848016281 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 271848016282 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 271848016283 DNA binding site [nucleotide binding] 271848016284 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 271848016285 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 271848016286 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 271848016287 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 271848016288 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 271848016289 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 271848016290 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 271848016291 RPB3 interaction site [polypeptide binding]; other site 271848016292 RPB1 interaction site [polypeptide binding]; other site 271848016293 RPB11 interaction site [polypeptide binding]; other site 271848016294 RPB10 interaction site [polypeptide binding]; other site 271848016295 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 271848016296 peripheral dimer interface [polypeptide binding]; other site 271848016297 core dimer interface [polypeptide binding]; other site 271848016298 L10 interface [polypeptide binding]; other site 271848016299 L11 interface [polypeptide binding]; other site 271848016300 putative EF-Tu interaction site [polypeptide binding]; other site 271848016301 putative EF-G interaction site [polypeptide binding]; other site 271848016302 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 271848016303 23S rRNA interface [nucleotide binding]; other site 271848016304 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 271848016305 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 271848016306 mRNA/rRNA interface [nucleotide binding]; other site 271848016307 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 271848016308 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 271848016309 23S rRNA interface [nucleotide binding]; other site 271848016310 L7/L12 interface [polypeptide binding]; other site 271848016311 putative thiostrepton binding site; other site 271848016312 L25 interface [polypeptide binding]; other site 271848016313 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 271848016314 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 271848016315 putative homodimer interface [polypeptide binding]; other site 271848016316 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 271848016317 heterodimer interface [polypeptide binding]; other site 271848016318 homodimer interface [polypeptide binding]; other site 271848016319 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 271848016320 elongation factor Tu; Reviewed; Region: PRK00049 271848016321 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 271848016322 G1 box; other site 271848016323 GEF interaction site [polypeptide binding]; other site 271848016324 GTP/Mg2+ binding site [chemical binding]; other site 271848016325 Switch I region; other site 271848016326 G2 box; other site 271848016327 G3 box; other site 271848016328 Switch II region; other site 271848016329 G4 box; other site 271848016330 G5 box; other site 271848016331 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 271848016332 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 271848016333 Antibiotic Binding Site [chemical binding]; other site 271848016334 Integrase core domain; Region: rve; pfam00665 271848016335 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 271848016336 Transposase; Region: HTH_Tnp_1; pfam01527 271848016337 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 271848016338 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 271848016339 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 271848016340 active site 271848016341 catalytic triad [active] 271848016342 oxyanion hole [active] 271848016343 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 271848016344 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 271848016345 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 271848016346 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 271848016347 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 271848016348 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 271848016349 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 271848016350 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 271848016351 FAD binding pocket [chemical binding]; other site 271848016352 FAD binding motif [chemical binding]; other site 271848016353 phosphate binding motif [ion binding]; other site 271848016354 beta-alpha-beta structure motif; other site 271848016355 NAD(p) ribose binding residues [chemical binding]; other site 271848016356 NAD binding pocket [chemical binding]; other site 271848016357 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 271848016358 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 271848016359 catalytic loop [active] 271848016360 iron binding site [ion binding]; other site 271848016361 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 271848016362 Protein of unknown function; Region: DUF3658; pfam12395 271848016363 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 271848016364 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 271848016365 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 271848016366 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 271848016367 Coenzyme A binding pocket [chemical binding]; other site 271848016368 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 271848016369 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 271848016370 putative DNA binding site [nucleotide binding]; other site 271848016371 putative Zn2+ binding site [ion binding]; other site 271848016372 AsnC family; Region: AsnC_trans_reg; pfam01037 271848016373 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 271848016374 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 271848016375 dimer interface [polypeptide binding]; other site 271848016376 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 271848016377 active site 271848016378 Fe binding site [ion binding]; other site 271848016379 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 271848016380 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 271848016381 dimer interface [polypeptide binding]; other site 271848016382 PYR/PP interface [polypeptide binding]; other site 271848016383 TPP binding site [chemical binding]; other site 271848016384 substrate binding site [chemical binding]; other site 271848016385 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 271848016386 TPP-binding site; other site 271848016387 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 271848016388 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 271848016389 Malic enzyme, N-terminal domain; Region: malic; pfam00390 271848016390 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 271848016391 putative NAD(P) binding site [chemical binding]; other site 271848016392 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 271848016393 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 271848016394 active site 271848016395 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 271848016396 substrate binding site [chemical binding]; other site 271848016397 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 271848016398 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 271848016399 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 271848016400 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 271848016401 Protein of unknown function (DUF2957); Region: DUF2957; pfam11170 271848016402 Protein of unknown function (DUF2957); Region: DUF2957; pfam11170 271848016403 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 271848016404 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 271848016405 Transposase; Region: DDE_Tnp_ISL3; pfam01610 271848016406 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848016407 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848016408 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 271848016409 dimerization interface [polypeptide binding]; other site 271848016410 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 271848016411 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 271848016412 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 271848016413 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 271848016414 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 271848016415 Uncharacterized conserved protein [Function unknown]; Region: COG1656 271848016416 Protein of unknown function DUF82; Region: DUF82; pfam01927 271848016417 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 271848016418 Spore germination protein; Region: Spore_permease; cl17796 271848016419 Transposase, Mutator family; Region: Transposase_mut; pfam00872 271848016420 MULE transposase domain; Region: MULE; pfam10551 271848016421 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 271848016422 active site 271848016423 DNA binding site [nucleotide binding] 271848016424 Int/Topo IB signature motif; other site 271848016425 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 271848016426 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 271848016427 non-specific DNA binding site [nucleotide binding]; other site 271848016428 salt bridge; other site 271848016429 sequence-specific DNA binding site [nucleotide binding]; other site 271848016430 multiple promoter invertase; Provisional; Region: mpi; PRK13413 271848016431 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 271848016432 catalytic residues [active] 271848016433 catalytic nucleophile [active] 271848016434 Presynaptic Site I dimer interface [polypeptide binding]; other site 271848016435 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 271848016436 Synaptic Flat tetramer interface [polypeptide binding]; other site 271848016437 Synaptic Site I dimer interface [polypeptide binding]; other site 271848016438 DNA binding site [nucleotide binding] 271848016439 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 271848016440 DNA-binding interface [nucleotide binding]; DNA binding site 271848016441 AAA domain; Region: AAA_21; pfam13304 271848016442 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 271848016443 ABC transporter signature motif; other site 271848016444 Walker B; other site 271848016445 D-loop; other site 271848016446 H-loop/switch region; other site 271848016447 Uncharacterized conserved protein [Function unknown]; Region: COG4983 271848016448 Bifunctional DNA primase/polymerase, N-terminal; Region: Prim-Pol; pfam09250 271848016449 AAA domain; Region: AAA_25; pfam13481 271848016450 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 271848016451 Walker A motif; other site 271848016452 ATP binding site [chemical binding]; other site 271848016453 Walker B motif; other site 271848016454 Transposase, Mutator family; Region: Transposase_mut; pfam00872 271848016455 MULE transposase domain; Region: MULE; pfam10551 271848016456 Predicted helicase [General function prediction only]; Region: COG4889 271848016457 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 271848016458 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 271848016459 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 271848016460 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 271848016461 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 271848016462 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 271848016463 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 271848016464 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 271848016465 Transposase; Region: HTH_Tnp_1; pfam01527 271848016466 Restriction endonuclease; Region: Mrr_cat_2; pfam13156 271848016467 Predicted helicase [General function prediction only]; Region: COG4889 271848016468 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 271848016469 ATP binding site [chemical binding]; other site 271848016470 putative Mg++ binding site [ion binding]; other site 271848016471 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 271848016472 ATP-binding site [chemical binding]; other site 271848016473 Cytochrome c; Region: Cytochrom_C; cl11414 271848016474 outer membrane lipoprotein; Provisional; Region: PRK11023 271848016475 BON domain; Region: BON; pfam04972 271848016476 BON domain; Region: BON; pfam04972 271848016477 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 271848016478 dimer interface [polypeptide binding]; other site 271848016479 active site 271848016480 hypothetical protein; Provisional; Region: PRK14673 271848016481 Predicted methyltransferases [General function prediction only]; Region: COG0313 271848016482 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 271848016483 putative SAM binding site [chemical binding]; other site 271848016484 putative homodimer interface [polypeptide binding]; other site 271848016485 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 271848016486 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 271848016487 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 271848016488 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 271848016489 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 271848016490 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 271848016491 putative DNA binding site [nucleotide binding]; other site 271848016492 putative Zn2+ binding site [ion binding]; other site 271848016493 AsnC family; Region: AsnC_trans_reg; pfam01037 271848016494 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 271848016495 Cation efflux family; Region: Cation_efflux; pfam01545 271848016496 H-NS histone family; Region: Histone_HNS; pfam00816 271848016497 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 271848016498 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 271848016499 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 271848016500 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 271848016501 dimerization interface [polypeptide binding]; other site 271848016502 ligand binding site [chemical binding]; other site 271848016503 Nitronate monooxygenase; Region: NMO; pfam03060 271848016504 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 271848016505 FMN binding site [chemical binding]; other site 271848016506 substrate binding site [chemical binding]; other site 271848016507 putative catalytic residue [active] 271848016508 Dienelactone hydrolase family; Region: DLH; pfam01738 271848016509 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 271848016510 Amidase; Region: Amidase; cl11426 271848016511 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 271848016512 Transposase; Region: DDE_Tnp_ISL3; pfam01610 271848016513 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 271848016514 FAD binding site [chemical binding]; other site 271848016515 Predicted membrane protein [Function unknown]; Region: COG1950 271848016516 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 271848016517 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 271848016518 homotetramer interface [polypeptide binding]; other site 271848016519 ligand binding site [chemical binding]; other site 271848016520 catalytic site [active] 271848016521 NAD binding site [chemical binding]; other site 271848016522 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 271848016523 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 271848016524 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 271848016525 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 271848016526 DNA binding residues [nucleotide binding] 271848016527 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 271848016528 flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14722 271848016529 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 271848016530 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 271848016531 FHIPEP family; Region: FHIPEP; pfam00771 271848016532 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 271848016533 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 271848016534 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 271848016535 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 271848016536 dimer interface [polypeptide binding]; other site 271848016537 Protein of unknown function (DUF3443); Region: DUF3443; pfam11925 271848016538 Protein of unknown function (DUF2844); Region: DUF2844; pfam11005 271848016539 chemotaxis regulator CheZ; Provisional; Region: PRK11166 271848016540 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 271848016541 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848016542 active site 271848016543 phosphorylation site [posttranslational modification] 271848016544 intermolecular recognition site; other site 271848016545 dimerization interface [polypeptide binding]; other site 271848016546 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 271848016547 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848016548 active site 271848016549 phosphorylation site [posttranslational modification] 271848016550 intermolecular recognition site; other site 271848016551 dimerization interface [polypeptide binding]; other site 271848016552 CheB methylesterase; Region: CheB_methylest; pfam01339 271848016553 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13489 271848016554 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 271848016555 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 271848016556 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848016557 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 271848016558 dimer interface [polypeptide binding]; other site 271848016559 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 271848016560 dimerization interface [polypeptide binding]; other site 271848016561 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 271848016562 dimer interface [polypeptide binding]; other site 271848016563 putative CheW interface [polypeptide binding]; other site 271848016564 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 271848016565 putative CheA interaction surface; other site 271848016566 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 271848016567 putative binding surface; other site 271848016568 active site 271848016569 CheY binding; Region: CheY-binding; pfam09078 271848016570 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 271848016571 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848016572 ATP binding site [chemical binding]; other site 271848016573 Mg2+ binding site [ion binding]; other site 271848016574 G-X-G motif; other site 271848016575 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 271848016576 Response regulator receiver domain; Region: Response_reg; pfam00072 271848016577 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848016578 active site 271848016579 phosphorylation site [posttranslational modification] 271848016580 intermolecular recognition site; other site 271848016581 dimerization interface [polypeptide binding]; other site 271848016582 flagellar motor protein MotB; Validated; Region: motB; PRK09041 271848016583 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 271848016584 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 271848016585 ligand binding site [chemical binding]; other site 271848016586 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 271848016587 flagellar motor protein MotA; Validated; Region: PRK09110 271848016588 transcriptional activator FlhC; Provisional; Region: PRK12722 271848016589 transcriptional activator FlhD; Provisional; Region: PRK02909 271848016590 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 271848016591 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 271848016592 putative ADP-binding pocket [chemical binding]; other site 271848016593 H-NS histone family; Region: Histone_HNS; pfam00816 271848016594 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 271848016595 amphipathic channel; other site 271848016596 Asn-Pro-Ala signature motifs; other site 271848016597 putative hydrolase; Provisional; Region: PRK10976 271848016598 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 271848016599 active site 271848016600 motif I; other site 271848016601 motif II; other site 271848016602 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 271848016603 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 271848016604 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 271848016605 Transposase; Region: DEDD_Tnp_IS110; pfam01548 271848016606 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 271848016607 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 271848016608 flagellin; Reviewed; Region: PRK08869 271848016609 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 271848016610 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 271848016611 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 271848016612 Flagellar protein FliT; Region: FliT; pfam05400 271848016613 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 271848016614 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 271848016615 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 271848016616 acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397 271848016617 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4380 271848016618 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259 271848016619 Curli production assembly/transport component CsgG; Region: CsgG; pfam03783 271848016620 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 271848016621 tRNA_anti-like; Region: tRNA_anti-like; pfam12869 271848016622 Cache domain; Region: Cache_1; pfam02743 271848016623 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 271848016624 dimerization interface [polypeptide binding]; other site 271848016625 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 271848016626 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 271848016627 dimer interface [polypeptide binding]; other site 271848016628 putative CheW interface [polypeptide binding]; other site 271848016629 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 271848016630 Tetratricopeptide repeat; Region: TPR_16; pfam13432 271848016631 TPR motif; other site 271848016632 binding surface 271848016633 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 271848016634 binding surface 271848016635 TPR repeat; Region: TPR_11; pfam13414 271848016636 TPR motif; other site 271848016637 Tetratricopeptide repeat; Region: TPR_16; pfam13432 271848016638 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 271848016639 TPR motif; other site 271848016640 binding surface 271848016641 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 271848016642 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 271848016643 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 271848016644 inhibitor-cofactor binding pocket; inhibition site 271848016645 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848016646 catalytic residue [active] 271848016647 WbqC-like protein family; Region: WbqC; pfam08889 271848016648 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848016649 S-adenosylmethionine binding site [chemical binding]; other site 271848016650 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 271848016651 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 271848016652 putative trimer interface [polypeptide binding]; other site 271848016653 putative CoA binding site [chemical binding]; other site 271848016654 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 271848016655 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 271848016656 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 271848016657 trimer interface [polypeptide binding]; other site 271848016658 active site 271848016659 substrate binding site [chemical binding]; other site 271848016660 CoA binding site [chemical binding]; other site 271848016661 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 271848016662 FAD binding domain; Region: FAD_binding_4; pfam01565 271848016663 Berberine and berberine like; Region: BBE; pfam08031 271848016664 Chitin binding domain; Region: Chitin_bind_3; pfam03067 271848016665 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 271848016666 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 271848016667 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 271848016668 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 271848016669 Coenzyme A binding pocket [chemical binding]; other site 271848016670 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 271848016671 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 271848016672 H-NS histone family; Region: Histone_HNS; pfam00816 271848016673 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 271848016674 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 271848016675 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 271848016676 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 271848016677 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 271848016678 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253 271848016679 Protein of unknown function (DUF3274); Region: DUF3274; pfam11678 271848016680 Protein of unknown function (DUF2875); Region: DUF2875; pfam11394 271848016681 Uncharacterized conserved protein [Function unknown]; Region: COG4104 271848016682 Integrase core domain; Region: rve; pfam00665 271848016683 Protein of unknown function (DUF3274); Region: DUF3274; pfam11678 271848016684 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 271848016685 multiple promoter invertase; Provisional; Region: mpi; PRK13413 271848016686 catalytic residues [active] 271848016687 catalytic nucleophile [active] 271848016688 Presynaptic Site I dimer interface [polypeptide binding]; other site 271848016689 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 271848016690 Synaptic Flat tetramer interface [polypeptide binding]; other site 271848016691 Synaptic Site I dimer interface [polypeptide binding]; other site 271848016692 DNA binding site [nucleotide binding] 271848016693 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 271848016694 DNA-binding interface [nucleotide binding]; DNA binding site 271848016695 integrase; Provisional; Region: PRK09692 271848016696 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 271848016697 active site 271848016698 Int/Topo IB signature motif; other site 271848016699 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 271848016700 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 271848016701 trmE is a tRNA modification GTPase; Region: trmE; cd04164 271848016702 G1 box; other site 271848016703 GTP/Mg2+ binding site [chemical binding]; other site 271848016704 Switch I region; other site 271848016705 G2 box; other site 271848016706 Switch II region; other site 271848016707 G3 box; other site 271848016708 G4 box; other site 271848016709 G5 box; other site 271848016710 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 271848016711 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 271848016712 sequence-specific DNA binding site [nucleotide binding]; other site 271848016713 salt bridge; other site 271848016714 membrane protein insertase; Provisional; Region: PRK01318 271848016715 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 271848016716 hypothetical protein; Validated; Region: PRK00041 271848016717 Ribonuclease P; Region: Ribonuclease_P; cl00457 271848016718 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 271848016719 DnaA N-terminal domain; Region: DnaA_N; pfam11638 271848016720 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 271848016721 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848016722 Walker A motif; other site 271848016723 ATP binding site [chemical binding]; other site 271848016724 Walker B motif; other site 271848016725 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 271848016726 arginine finger; other site 271848016727 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 271848016728 DnaA box-binding interface [nucleotide binding]; other site 271848016729 DNA polymerase III subunit beta; Validated; Region: PRK05643 271848016730 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 271848016731 putative DNA binding surface [nucleotide binding]; other site 271848016732 dimer interface [polypeptide binding]; other site 271848016733 beta-clamp/clamp loader binding surface; other site 271848016734 beta-clamp/translesion DNA polymerase binding surface; other site 271848016735 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 271848016736 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848016737 ATP binding site [chemical binding]; other site 271848016738 Mg2+ binding site [ion binding]; other site 271848016739 G-X-G motif; other site 271848016740 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 271848016741 anchoring element; other site 271848016742 dimer interface [polypeptide binding]; other site 271848016743 ATP binding site [chemical binding]; other site 271848016744 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 271848016745 active site 271848016746 putative metal-binding site [ion binding]; other site 271848016747 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 271848016748 TIR domain; Region: TIR_2; pfam13676 271848016749 HNH endonuclease; Region: HNH_2; pfam13391 271848016750 Transposase, Mutator family; Region: Transposase_mut; pfam00872 271848016751 MULE transposase domain; Region: MULE; pfam10551 271848016752 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848016753 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848016754 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848016755 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 271848016756 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 271848016757 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 271848016758 NAD(P) binding site [chemical binding]; other site 271848016759 catalytic residues [active] 271848016760 Helix-turn-helix domain; Region: HTH_18; pfam12833 271848016761 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 271848016762 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 271848016763 thiamine pyrophosphate protein; Validated; Region: PRK08199 271848016764 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 271848016765 PYR/PP interface [polypeptide binding]; other site 271848016766 dimer interface [polypeptide binding]; other site 271848016767 TPP binding site [chemical binding]; other site 271848016768 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 271848016769 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 271848016770 TPP-binding site [chemical binding]; other site 271848016771 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 271848016772 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 271848016773 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 271848016774 Alginate lyase; Region: Alginate_lyase; pfam05426 271848016775 glycine dehydrogenase; Provisional; Region: PRK05367 271848016776 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 271848016777 tetramer interface [polypeptide binding]; other site 271848016778 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848016779 catalytic residue [active] 271848016780 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 271848016781 tetramer interface [polypeptide binding]; other site 271848016782 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848016783 catalytic residue [active] 271848016784 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 271848016785 lipoyl attachment site [posttranslational modification]; other site 271848016786 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 271848016787 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 271848016788 putative oxidoreductase; Provisional; Region: PRK11579 271848016789 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 271848016790 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 271848016791 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 271848016792 active site 271848016793 catalytic triad [active] 271848016794 oxyanion hole [active] 271848016795 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 271848016796 Part of AAA domain; Region: AAA_19; pfam13245 271848016797 Family description; Region: UvrD_C_2; pfam13538 271848016798 Cytochrome c; Region: Cytochrom_C; cl11414 271848016799 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 271848016800 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 271848016801 non-specific DNA binding site [nucleotide binding]; other site 271848016802 salt bridge; other site 271848016803 sequence-specific DNA binding site [nucleotide binding]; other site 271848016804 Neisseria meningitidis TspB protein; Region: Neisseria_TspB; pfam05616 271848016805 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 271848016806 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 271848016807 Walker A motif; other site 271848016808 ATP binding site [chemical binding]; other site 271848016809 Walker B motif; other site 271848016810 arginine finger; other site 271848016811 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 271848016812 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 271848016813 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 271848016814 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 271848016815 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 271848016816 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 271848016817 active site 271848016818 DNA binding site [nucleotide binding] 271848016819 Int/Topo IB signature motif; other site 271848016820 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 271848016821 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 271848016822 non-specific DNA binding site [nucleotide binding]; other site 271848016823 salt bridge; other site 271848016824 sequence-specific DNA binding site [nucleotide binding]; other site 271848016825 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 271848016826 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 271848016827 active site 271848016828 DNA binding site [nucleotide binding] 271848016829 Int/Topo IB signature motif; other site 271848016830 Transposase, Mutator family; Region: Transposase_mut; pfam00872 271848016831 MULE transposase domain; Region: MULE; pfam10551 271848016832 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 271848016833 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 271848016834 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 271848016835 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 271848016836 ethanolamine permease; Region: 2A0305; TIGR00908 271848016837 hypothetical protein; Provisional; Region: PHA02764 271848016838 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 271848016839 Acyltransferase family; Region: Acyl_transf_3; pfam01757 271848016840 Conserved TM helix; Region: TM_helix; pfam05552 271848016841 Conserved TM helix; Region: TM_helix; pfam05552 271848016842 Conserved TM helix; Region: TM_helix; pfam05552 271848016843 Double zinc ribbon; Region: DZR; pfam12773 271848016844 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 271848016845 Heavy-metal-associated domain; Region: HMA; pfam00403 271848016846 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 271848016847 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 271848016848 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 271848016849 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 271848016850 DNA binding residues [nucleotide binding] 271848016851 dimer interface [polypeptide binding]; other site 271848016852 putative metal binding site [ion binding]; other site 271848016853 Predicted transcriptional regulators [Transcription]; Region: COG1695 271848016854 Transcriptional regulator PadR-like family; Region: PadR; cl17335 271848016855 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 271848016856 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 271848016857 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 271848016858 substrate binding pocket [chemical binding]; other site 271848016859 membrane-bound complex binding site; other site 271848016860 hinge residues; other site 271848016861 putative aminotransferase; Provisional; Region: PRK12414 271848016862 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 271848016863 pyridoxal 5'-phosphate binding site [chemical binding]; other site 271848016864 homodimer interface [polypeptide binding]; other site 271848016865 catalytic residue [active] 271848016866 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 271848016867 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 271848016868 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 271848016869 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 271848016870 active site 271848016871 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 271848016872 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 271848016873 acyl-activating enzyme (AAE) consensus motif; other site 271848016874 AMP binding site [chemical binding]; other site 271848016875 active site 271848016876 CoA binding site [chemical binding]; other site 271848016877 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 271848016878 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 271848016879 dimerization interface [polypeptide binding]; other site 271848016880 ligand binding site [chemical binding]; other site 271848016881 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 271848016882 Predicted transcriptional regulator [Transcription]; Region: COG3905 271848016883 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 271848016884 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 271848016885 Glutamate binding site [chemical binding]; other site 271848016886 NAD binding site [chemical binding]; other site 271848016887 catalytic residues [active] 271848016888 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 271848016889 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 271848016890 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 271848016891 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 271848016892 ATP binding site [chemical binding]; other site 271848016893 putative Mg++ binding site [ion binding]; other site 271848016894 nucleotide binding region [chemical binding]; other site 271848016895 helicase superfamily c-terminal domain; Region: HELICc; smart00490 271848016896 ATP-binding site [chemical binding]; other site 271848016897 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 271848016898 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 271848016899 substrate binding site [chemical binding]; other site 271848016900 active site 271848016901 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 271848016902 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 271848016903 substrate binding pocket [chemical binding]; other site 271848016904 membrane-bound complex binding site; other site 271848016905 hinge residues; other site 271848016906 AMP-binding domain protein; Validated; Region: PRK08315 271848016907 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 271848016908 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 271848016909 acyl-activating enzyme (AAE) consensus motif; other site 271848016910 putative AMP binding site [chemical binding]; other site 271848016911 putative active site [active] 271848016912 putative CoA binding site [chemical binding]; other site 271848016913 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 271848016914 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 271848016915 gamma subunit interface [polypeptide binding]; other site 271848016916 epsilon subunit interface [polypeptide binding]; other site 271848016917 LBP interface [polypeptide binding]; other site 271848016918 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 271848016919 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 271848016920 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 271848016921 alpha subunit interaction interface [polypeptide binding]; other site 271848016922 Walker A motif; other site 271848016923 ATP binding site [chemical binding]; other site 271848016924 Walker B motif; other site 271848016925 inhibitor binding site; inhibition site 271848016926 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 271848016927 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 271848016928 core domain interface [polypeptide binding]; other site 271848016929 delta subunit interface [polypeptide binding]; other site 271848016930 epsilon subunit interface [polypeptide binding]; other site 271848016931 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 271848016932 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 271848016933 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 271848016934 beta subunit interaction interface [polypeptide binding]; other site 271848016935 Walker A motif; other site 271848016936 ATP binding site [chemical binding]; other site 271848016937 Walker B motif; other site 271848016938 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 271848016939 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 271848016940 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 271848016941 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 271848016942 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 271848016943 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 271848016944 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 271848016945 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 271848016946 ATP synthase I chain; Region: ATP_synt_I; pfam03899 271848016947 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 271848016948 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 271848016949 transmembrane helices; other site 271848016950 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 271848016951 ParB-like nuclease domain; Region: ParBc; pfam02195 271848016952 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 271848016953 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 271848016954 P-loop; other site 271848016955 Magnesium ion binding site [ion binding]; other site 271848016956 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 271848016957 Magnesium ion binding site [ion binding]; other site 271848016958 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 271848016959 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 271848016960 S-adenosylmethionine binding site [chemical binding]; other site 271848016961 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 271848016962 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 271848016963 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 271848016964 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 271848016965 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 271848016966 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 271848016967 Walker A/P-loop; other site 271848016968 ATP binding site [chemical binding]; other site 271848016969 Q-loop/lid; other site 271848016970 ABC transporter signature motif; other site 271848016971 Walker B; other site 271848016972 D-loop; other site 271848016973 H-loop/switch region; other site 271848016974 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 271848016975 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 271848016976 TM-ABC transporter signature motif; other site 271848016977 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 271848016978 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 271848016979 Walker A/P-loop; other site 271848016980 ATP binding site [chemical binding]; other site 271848016981 Q-loop/lid; other site 271848016982 ABC transporter signature motif; other site 271848016983 Walker B; other site 271848016984 D-loop; other site 271848016985 H-loop/switch region; other site 271848016986 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 271848016987 TM-ABC transporter signature motif; other site 271848016988 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 271848016989 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 271848016990 putative ligand binding site [chemical binding]; other site 271848016991 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 271848016992 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 271848016993 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 271848016994 TM-ABC transporter signature motif; other site 271848016995 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 271848016996 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 271848016997 TM-ABC transporter signature motif; other site 271848016998 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 271848016999 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 271848017000 putative ligand binding site [chemical binding]; other site 271848017001 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 271848017002 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 271848017003 Walker A/P-loop; other site 271848017004 ATP binding site [chemical binding]; other site 271848017005 Q-loop/lid; other site 271848017006 ABC transporter signature motif; other site 271848017007 Walker B; other site 271848017008 D-loop; other site 271848017009 H-loop/switch region; other site 271848017010 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 271848017011 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 271848017012 Walker A/P-loop; other site 271848017013 ATP binding site [chemical binding]; other site 271848017014 Q-loop/lid; other site 271848017015 ABC transporter signature motif; other site 271848017016 Walker B; other site 271848017017 D-loop; other site 271848017018 H-loop/switch region; other site 271848017019 choline dehydrogenase; Validated; Region: PRK02106 271848017020 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 271848017021 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 271848017022 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 271848017023 tetrameric interface [polypeptide binding]; other site 271848017024 NAD binding site [chemical binding]; other site 271848017025 catalytic residues [active] 271848017026 Transcriptional regulator [Transcription]; Region: LysR; COG0583 271848017027 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 271848017028 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 271848017029 dimerization interface [polypeptide binding]; other site 271848017030 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 271848017031 putative active site [active] 271848017032 putative metal binding residues [ion binding]; other site 271848017033 signature motif; other site 271848017034 putative triphosphate binding site [ion binding]; other site 271848017035 dimer interface [polypeptide binding]; other site 271848017036 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 271848017037 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 271848017038 putative DNA binding site [nucleotide binding]; other site 271848017039 putative Zn2+ binding site [ion binding]; other site 271848017040 AsnC family; Region: AsnC_trans_reg; pfam01037 271848017041 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 271848017042 cofactor binding site; other site 271848017043 metal binding site [ion binding]; metal-binding site 271848017044 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 271848017045 aromatic arch; other site 271848017046 DCoH dimer interaction site [polypeptide binding]; other site 271848017047 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 271848017048 DCoH tetramer interaction site [polypeptide binding]; other site 271848017049 substrate binding site [chemical binding]; other site 271848017050 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 271848017051 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 271848017052 active site 271848017053 phosphorylation site [posttranslational modification] 271848017054 intermolecular recognition site; other site 271848017055 dimerization interface [polypeptide binding]; other site 271848017056 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 271848017057 DNA binding site [nucleotide binding] 271848017058 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 271848017059 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 271848017060 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 271848017061 dimer interface [polypeptide binding]; other site 271848017062 phosphorylation site [posttranslational modification] 271848017063 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 271848017064 ATP binding site [chemical binding]; other site 271848017065 Mg2+ binding site [ion binding]; other site 271848017066 G-X-G motif; other site 271848017067 Proteins containing SET domain [General function prediction only]; Region: COG2940 271848017068 SET domain; Region: SET; pfam00856 271848017069 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 271848017070 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 271848017071 active site 271848017072 FMN binding site [chemical binding]; other site 271848017073 substrate binding site [chemical binding]; other site 271848017074 homotetramer interface [polypeptide binding]; other site 271848017075 catalytic residue [active] 271848017076 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 271848017077 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 271848017078 catalytic triad [active] 271848017079 Transcriptional regulators [Transcription]; Region: MarR; COG1846 271848017080 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 271848017081 putative DNA binding site [nucleotide binding]; other site 271848017082 putative Zn2+ binding site [ion binding]; other site