-- dump date 20140619_014629 -- class Genbank::misc_feature -- table misc_feature_note -- id note 357348000001 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 357348000002 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 357348000003 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 357348000004 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 357348000005 Uncharacterized conserved protein [Function unknown]; Region: COG4121 357348000006 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 357348000007 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 357348000008 IHF dimer interface [polypeptide binding]; other site 357348000009 IHF - DNA interface [nucleotide binding]; other site 357348000010 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 357348000011 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 357348000012 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 357348000013 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 357348000014 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 357348000015 N-acetyl-D-glucosamine binding site [chemical binding]; other site 357348000016 catalytic residue [active] 357348000017 type II secretion system protein D; Region: type_II_gspD; TIGR02517 357348000018 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 357348000019 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 357348000020 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 357348000021 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 357348000022 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 357348000023 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 357348000024 type II secretion system protein E; Region: type_II_gspE; TIGR02533 357348000025 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 357348000026 Walker A motif; other site 357348000027 ATP binding site [chemical binding]; other site 357348000028 Walker B motif; other site 357348000029 type II secretion system protein F; Region: GspF; TIGR02120 357348000030 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 357348000031 Ceramidase; Region: Ceramidase; pfam05875 357348000032 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 357348000033 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 357348000034 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 357348000035 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 357348000036 type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708 357348000037 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 357348000038 Type II transport protein GspH; Region: GspH; pfam12019 357348000039 type II secretion system protein I; Region: gspI; TIGR01707 357348000040 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 357348000041 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 357348000042 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 357348000043 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 357348000044 GspL periplasmic domain; Region: GspL_C; pfam12693 357348000045 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 357348000046 Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203 357348000047 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 357348000048 MarR family; Region: MarR_2; cl17246 357348000049 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 357348000050 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 357348000051 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348000052 putative substrate translocation pore; other site 357348000053 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348000054 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357348000055 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348000056 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 357348000057 putative dimerization interface [polypeptide binding]; other site 357348000058 LrgA family; Region: LrgA; pfam03788 357348000059 LrgB-like family; Region: LrgB; cl00596 357348000060 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 357348000061 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 357348000062 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 357348000063 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 357348000064 flagellar motor switch protein; Validated; Region: fliN; PRK05698 357348000065 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 357348000066 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 357348000067 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 357348000068 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 357348000069 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 357348000070 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781 357348000071 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 357348000072 DNA binding residues [nucleotide binding] 357348000073 putative dimer interface [polypeptide binding]; other site 357348000074 putative metal binding residues [ion binding]; other site 357348000075 Methyltransferase domain; Region: Methyltransf_31; pfam13847 357348000076 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357348000077 S-adenosylmethionine binding site [chemical binding]; other site 357348000078 Protein of unknown function (DUF2938); Region: DUF2938; pfam11158 357348000079 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 357348000080 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 357348000081 membrane-bound complex binding site; other site 357348000082 hinge residues; other site 357348000083 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 357348000084 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 357348000085 Walker A/P-loop; other site 357348000086 ATP binding site [chemical binding]; other site 357348000087 Q-loop/lid; other site 357348000088 ABC transporter signature motif; other site 357348000089 Walker B; other site 357348000090 D-loop; other site 357348000091 H-loop/switch region; other site 357348000092 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 357348000093 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348000094 dimer interface [polypeptide binding]; other site 357348000095 conserved gate region; other site 357348000096 putative PBP binding loops; other site 357348000097 ABC-ATPase subunit interface; other site 357348000098 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 357348000099 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357348000100 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357348000101 dimer interface [polypeptide binding]; other site 357348000102 phosphorylation site [posttranslational modification] 357348000103 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357348000104 ATP binding site [chemical binding]; other site 357348000105 Mg2+ binding site [ion binding]; other site 357348000106 G-X-G motif; other site 357348000107 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 357348000108 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348000109 active site 357348000110 phosphorylation site [posttranslational modification] 357348000111 intermolecular recognition site; other site 357348000112 dimerization interface [polypeptide binding]; other site 357348000113 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357348000114 DNA binding site [nucleotide binding] 357348000115 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 357348000116 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 357348000117 trimer interface [polypeptide binding]; other site 357348000118 eyelet of channel; other site 357348000119 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 357348000120 DNA methylase; Region: N6_N4_Mtase; pfam01555 357348000121 DNA methylase; Region: N6_N4_Mtase; cl17433 357348000122 Restriction endonuclease [Defense mechanisms]; Region: COG3587 357348000123 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 357348000124 ATP binding site [chemical binding]; other site 357348000125 putative Mg++ binding site [ion binding]; other site 357348000126 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 357348000127 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 357348000128 trimer interface [polypeptide binding]; other site 357348000129 eyelet of channel; other site 357348000130 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 357348000131 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357348000132 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 357348000133 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 357348000134 Walker A/P-loop; other site 357348000135 ATP binding site [chemical binding]; other site 357348000136 Q-loop/lid; other site 357348000137 ABC transporter signature motif; other site 357348000138 Walker B; other site 357348000139 D-loop; other site 357348000140 H-loop/switch region; other site 357348000141 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 357348000142 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357348000143 Walker A/P-loop; other site 357348000144 ATP binding site [chemical binding]; other site 357348000145 Q-loop/lid; other site 357348000146 ABC transporter signature motif; other site 357348000147 Walker B; other site 357348000148 D-loop; other site 357348000149 H-loop/switch region; other site 357348000150 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 357348000151 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 357348000152 TM-ABC transporter signature motif; other site 357348000153 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 357348000154 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 357348000155 TM-ABC transporter signature motif; other site 357348000156 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 357348000157 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 357348000158 putative ligand binding site [chemical binding]; other site 357348000159 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 357348000160 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 357348000161 NAD(P) binding site [chemical binding]; other site 357348000162 catalytic residues [active] 357348000163 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 357348000164 Molybdenum cofactor biosynthesis protein F; Region: MoaF; pfam10703 357348000165 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 357348000166 classical (c) SDRs; Region: SDR_c; cd05233 357348000167 NAD(P) binding site [chemical binding]; other site 357348000168 active site 357348000169 choline dehydrogenase; Validated; Region: PRK02106 357348000170 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 357348000171 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 357348000172 Predicted transcriptional regulators [Transcription]; Region: COG1695 357348000173 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 357348000174 Predicted membrane protein [Function unknown]; Region: COG4709 357348000175 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 357348000176 Fatty acid desaturase; Region: FA_desaturase; pfam00487 357348000177 putative di-iron ligands [ion binding]; other site 357348000178 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 357348000179 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 357348000180 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 357348000181 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 357348000182 conserved cys residue [active] 357348000183 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 357348000184 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 357348000185 active site 357348000186 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 357348000187 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 357348000188 dimer interface [polypeptide binding]; other site 357348000189 active site 357348000190 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 357348000191 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 357348000192 substrate binding site [chemical binding]; other site 357348000193 oxyanion hole (OAH) forming residues; other site 357348000194 trimer interface [polypeptide binding]; other site 357348000195 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 357348000196 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 357348000197 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 357348000198 CoA-transferase family III; Region: CoA_transf_3; pfam02515 357348000199 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 357348000200 CHAP domain; Region: CHAP; cl17642 357348000201 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 357348000202 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 357348000203 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 357348000204 DNA binding residues [nucleotide binding] 357348000205 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 357348000206 putative heme binding pocket [chemical binding]; other site 357348000207 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 357348000208 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria and archaea; Region: GIY-YIG_unchar_2; cd10447 357348000209 GIY-YIG motif/motif A; other site 357348000210 putative active site [active] 357348000211 putative metal binding site [ion binding]; other site 357348000212 Domain of unknown function (DUF4357); Region: DUF4357; pfam14267 357348000213 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 357348000214 DNA-binding interface [nucleotide binding]; DNA binding site 357348000215 Transposase; Region: HTH_Tnp_1; pfam01527 357348000216 Transposase; Region: HTH_Tnp_1; pfam01527 357348000217 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 357348000218 HTH-like domain; Region: HTH_21; pfam13276 357348000219 Integrase core domain; Region: rve; pfam00665 357348000220 Integrase core domain; Region: rve_3; pfam13683 357348000221 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 357348000222 active site 357348000223 NTP binding site [chemical binding]; other site 357348000224 metal binding triad [ion binding]; metal-binding site 357348000225 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 357348000226 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 357348000227 non-specific DNA binding site [nucleotide binding]; other site 357348000228 salt bridge; other site 357348000229 sequence-specific DNA binding site [nucleotide binding]; other site 357348000230 Domain of unknown function (DUF955); Region: DUF955; pfam06114 357348000231 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 357348000232 HsdM N-terminal domain; Region: HsdM_N; pfam12161 357348000233 Methyltransferase domain; Region: Methyltransf_26; pfam13659 357348000234 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 357348000235 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 357348000236 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 357348000237 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 357348000238 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 357348000239 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 357348000240 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 357348000241 Protein of unknown function DUF45; Region: DUF45; pfam01863 357348000242 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 357348000243 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357348000244 ATP binding site [chemical binding]; other site 357348000245 Mg2+ binding site [ion binding]; other site 357348000246 G-X-G motif; other site 357348000247 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 357348000248 anchoring element; other site 357348000249 dimer interface [polypeptide binding]; other site 357348000250 ATP binding site [chemical binding]; other site 357348000251 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 357348000252 active site 357348000253 putative metal-binding site [ion binding]; other site 357348000254 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 357348000255 DNA polymerase III subunit beta; Validated; Region: PRK05643 357348000256 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 357348000257 putative DNA binding surface [nucleotide binding]; other site 357348000258 dimer interface [polypeptide binding]; other site 357348000259 beta-clamp/clamp loader binding surface; other site 357348000260 beta-clamp/translesion DNA polymerase binding surface; other site 357348000261 DnaA N-terminal domain; Region: DnaA_N; pfam11638 357348000262 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 357348000263 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357348000264 Walker A motif; other site 357348000265 ATP binding site [chemical binding]; other site 357348000266 Walker B motif; other site 357348000267 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 357348000268 arginine finger; other site 357348000269 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 357348000270 DnaA box-binding interface [nucleotide binding]; other site 357348000271 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 357348000272 Ribonuclease P; Region: Ribonuclease_P; cl00457 357348000273 hypothetical protein; Validated; Region: PRK00041 357348000274 membrane protein insertase; Provisional; Region: PRK01318 357348000275 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 357348000276 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 357348000277 sequence-specific DNA binding site [nucleotide binding]; other site 357348000278 salt bridge; other site 357348000279 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 357348000280 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 357348000281 trmE is a tRNA modification GTPase; Region: trmE; cd04164 357348000282 G1 box; other site 357348000283 GTP/Mg2+ binding site [chemical binding]; other site 357348000284 Switch I region; other site 357348000285 G2 box; other site 357348000286 Switch II region; other site 357348000287 G3 box; other site 357348000288 G4 box; other site 357348000289 G5 box; other site 357348000290 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 357348000291 integrase; Provisional; Region: PRK09692 357348000292 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 357348000293 active site 357348000294 Int/Topo IB signature motif; other site 357348000295 Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707 357348000296 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 357348000297 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 357348000298 active site 357348000299 metal binding site [ion binding]; metal-binding site 357348000300 interdomain interaction site; other site 357348000301 Domain of unknown function (DUF927); Region: DUF927; pfam06048 357348000302 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 357348000303 Predicted nucleotidyltransferase [General function prediction only]; Region: COG4849 357348000304 HTH-like domain; Region: HTH_21; pfam13276 357348000305 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 357348000306 Integrase core domain; Region: rve; pfam00665 357348000307 Integrase core domain; Region: rve_3; pfam13683 357348000308 Transposase; Region: HTH_Tnp_1; pfam01527 357348000309 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 357348000310 Domain of unknown function (DUF4382); Region: DUF4382; pfam14321 357348000311 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 357348000312 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 357348000313 YaeQ protein; Region: YaeQ; pfam07152 357348000314 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 357348000315 dimer interface [polypeptide binding]; other site 357348000316 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 357348000317 metal binding site [ion binding]; metal-binding site 357348000318 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 357348000319 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 357348000320 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357348000321 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357348000322 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 357348000323 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 357348000324 DNA binding site [nucleotide binding] 357348000325 active site 357348000326 AlkA N-terminal domain; Region: AlkA_N; pfam06029 357348000327 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 357348000328 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 357348000329 minor groove reading motif; other site 357348000330 helix-hairpin-helix signature motif; other site 357348000331 substrate binding pocket [chemical binding]; other site 357348000332 active site 357348000333 glutamate--cysteine ligase; Provisional; Region: PRK02107 357348000334 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 357348000335 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 357348000336 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 357348000337 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 357348000338 DNA binding residues [nucleotide binding] 357348000339 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 357348000340 dimer interface [polypeptide binding]; other site 357348000341 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357348000342 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348000343 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 357348000344 putative effector binding pocket; other site 357348000345 dimerization interface [polypeptide binding]; other site 357348000346 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 357348000347 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 357348000348 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 357348000349 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 357348000350 active site 357348000351 metal binding site [ion binding]; metal-binding site 357348000352 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 357348000353 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 357348000354 putative active site; other site 357348000355 catalytic triad [active] 357348000356 putative dimer interface [polypeptide binding]; other site 357348000357 portal vertex protein; Provisional; Region: Q; PHA02536 357348000358 Phage portal protein; Region: Phage_portal; pfam04860 357348000359 probable addiction module antidote protein; Region: dnstrm_HI1420; TIGR02684 357348000360 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 357348000361 CoenzymeA binding site [chemical binding]; other site 357348000362 subunit interaction site [polypeptide binding]; other site 357348000363 PHB binding site; other site 357348000364 Patatin-like phospholipase; Region: Patatin; pfam01734 357348000365 active site 357348000366 nucleophile elbow; other site 357348000367 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 357348000368 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 357348000369 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 357348000370 dimerization interface [polypeptide binding]; other site 357348000371 NAD binding site [chemical binding]; other site 357348000372 ligand binding site [chemical binding]; other site 357348000373 catalytic site [active] 357348000374 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357348000375 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348000376 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 357348000377 putative effector binding pocket; other site 357348000378 dimerization interface [polypeptide binding]; other site 357348000379 DNA topoisomerase III; Validated; Region: PRK08173 357348000380 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 357348000381 active site 357348000382 putative interdomain interaction site [polypeptide binding]; other site 357348000383 putative metal-binding site [ion binding]; other site 357348000384 putative nucleotide binding site [chemical binding]; other site 357348000385 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 357348000386 domain I; other site 357348000387 DNA binding groove [nucleotide binding] 357348000388 phosphate binding site [ion binding]; other site 357348000389 domain II; other site 357348000390 domain III; other site 357348000391 nucleotide binding site [chemical binding]; other site 357348000392 catalytic site [active] 357348000393 domain IV; other site 357348000394 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 357348000395 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 357348000396 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 357348000397 catalytic residues [active] 357348000398 DNA protecting protein DprA; Region: dprA; TIGR00732 357348000399 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 357348000400 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 357348000401 active site 357348000402 catalytic residues [active] 357348000403 metal binding site [ion binding]; metal-binding site 357348000404 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 357348000405 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 357348000406 putative active site [active] 357348000407 substrate binding site [chemical binding]; other site 357348000408 putative cosubstrate binding site; other site 357348000409 catalytic site [active] 357348000410 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 357348000411 substrate binding site [chemical binding]; other site 357348000412 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 357348000413 M48 family peptidase; Provisional; Region: PRK03001 357348000414 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 357348000415 16S rRNA methyltransferase B; Provisional; Region: PRK10901 357348000416 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 357348000417 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357348000418 S-adenosylmethionine binding site [chemical binding]; other site 357348000419 Domain of unknown function (DUF4390); Region: DUF4390; pfam14334 357348000420 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 357348000421 dimerization interface [polypeptide binding]; other site 357348000422 PAS domain; Region: PAS; smart00091 357348000423 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 357348000424 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357348000425 dimer interface [polypeptide binding]; other site 357348000426 phosphorylation site [posttranslational modification] 357348000427 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357348000428 ATP binding site [chemical binding]; other site 357348000429 Mg2+ binding site [ion binding]; other site 357348000430 G-X-G motif; other site 357348000431 Response regulator receiver domain; Region: Response_reg; pfam00072 357348000432 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348000433 active site 357348000434 phosphorylation site [posttranslational modification] 357348000435 intermolecular recognition site; other site 357348000436 dimerization interface [polypeptide binding]; other site 357348000437 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 357348000438 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 357348000439 Ligand Binding Site [chemical binding]; other site 357348000440 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 357348000441 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 357348000442 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 357348000443 active site 357348000444 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 357348000445 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 357348000446 Sel1 repeat; Region: Sel1; cl02723 357348000447 Sel1-like repeats; Region: SEL1; smart00671 357348000448 Sel1-like repeats; Region: SEL1; smart00671 357348000449 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 357348000450 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 357348000451 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 357348000452 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 357348000453 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 357348000454 rod shape-determining protein MreC; Provisional; Region: PRK13922 357348000455 rod shape-determining protein MreC; Region: MreC; pfam04085 357348000456 rod shape-determining protein MreB; Provisional; Region: PRK13927 357348000457 MreB and similar proteins; Region: MreB_like; cd10225 357348000458 nucleotide binding site [chemical binding]; other site 357348000459 Mg binding site [ion binding]; other site 357348000460 putative protofilament interaction site [polypeptide binding]; other site 357348000461 RodZ interaction site [polypeptide binding]; other site 357348000462 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 357348000463 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 357348000464 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 357348000465 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 357348000466 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 357348000467 GatB domain; Region: GatB_Yqey; smart00845 357348000468 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 357348000469 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 357348000470 putative active site [active] 357348000471 putative catalytic site [active] 357348000472 putative DNA binding site [nucleotide binding]; other site 357348000473 putative phosphate binding site [ion binding]; other site 357348000474 metal binding site A [ion binding]; metal-binding site 357348000475 putative AP binding site [nucleotide binding]; other site 357348000476 putative metal binding site B [ion binding]; other site 357348000477 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 357348000478 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 357348000479 putative NAD(P) binding site [chemical binding]; other site 357348000480 putative substrate binding site [chemical binding]; other site 357348000481 catalytic Zn binding site [ion binding]; other site 357348000482 structural Zn binding site [ion binding]; other site 357348000483 dimer interface [polypeptide binding]; other site 357348000484 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 357348000485 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357348000486 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357348000487 Peptidase family M48; Region: Peptidase_M48; cl12018 357348000488 muropeptide transporter; Reviewed; Region: ampG; PRK11902 357348000489 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348000490 putative substrate translocation pore; other site 357348000491 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 357348000492 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 357348000493 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 357348000494 division inhibitor protein; Provisional; Region: slmA; PRK09480 357348000495 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 357348000496 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 357348000497 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 357348000498 feedback inhibition sensing region; other site 357348000499 homohexameric interface [polypeptide binding]; other site 357348000500 nucleotide binding site [chemical binding]; other site 357348000501 N-acetyl-L-glutamate binding site [chemical binding]; other site 357348000502 Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375 357348000503 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357348000504 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 357348000505 dimer interface [polypeptide binding]; other site 357348000506 phosphorylation site [posttranslational modification] 357348000507 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357348000508 ATP binding site [chemical binding]; other site 357348000509 Mg2+ binding site [ion binding]; other site 357348000510 G-X-G motif; other site 357348000511 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 357348000512 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348000513 active site 357348000514 phosphorylation site [posttranslational modification] 357348000515 intermolecular recognition site; other site 357348000516 dimerization interface [polypeptide binding]; other site 357348000517 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 357348000518 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 357348000519 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357348000520 Walker A motif; other site 357348000521 ATP binding site [chemical binding]; other site 357348000522 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 357348000523 Walker B motif; other site 357348000524 arginine finger; other site 357348000525 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 357348000526 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 357348000527 active site 357348000528 HslU subunit interaction site [polypeptide binding]; other site 357348000529 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 357348000530 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 357348000531 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 357348000532 P-loop, Walker A motif; other site 357348000533 Base recognition motif; other site 357348000534 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 357348000535 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 357348000536 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 357348000537 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 357348000538 putative RNA binding site [nucleotide binding]; other site 357348000539 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357348000540 S-adenosylmethionine binding site [chemical binding]; other site 357348000541 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 357348000542 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 357348000543 active site 357348000544 DNA binding site [nucleotide binding] 357348000545 Int/Topo IB signature motif; other site 357348000546 Protein of unknown function, DUF484; Region: DUF484; cl17449 357348000547 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 357348000548 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 357348000549 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 357348000550 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 357348000551 putative acyl-acceptor binding pocket; other site 357348000552 S-adenosylmethionine synthetase; Validated; Region: PRK05250 357348000553 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 357348000554 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 357348000555 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 357348000556 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 357348000557 Protein of unknown function (DUF3185); Region: DUF3185; pfam11381 357348000558 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 357348000559 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 357348000560 active site 357348000561 catalytic tetrad [active] 357348000562 EamA-like transporter family; Region: EamA; pfam00892 357348000563 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348000564 putative substrate translocation pore; other site 357348000565 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 357348000566 serine/threonine protein kinase; Provisional; Region: PRK11768 357348000567 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 357348000568 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 357348000569 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 357348000570 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 357348000571 NAD(P) binding site [chemical binding]; other site 357348000572 catalytic residues [active] 357348000573 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 357348000574 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 357348000575 active site 357348000576 choline dehydrogenase; Validated; Region: PRK02106 357348000577 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 357348000578 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 357348000579 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 357348000580 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 357348000581 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 357348000582 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 357348000583 Walker A motif/ATP binding site; other site 357348000584 Walker B motif; other site 357348000585 flagellar assembly protein H; Validated; Region: fliH; PRK05687 357348000586 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 357348000587 Flagellar assembly protein FliH; Region: FliH; pfam02108 357348000588 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 357348000589 FliG C-terminal domain; Region: FliG_C; pfam01706 357348000590 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 357348000591 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 357348000592 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 357348000593 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 357348000594 flagellar protein FliS; Validated; Region: fliS; PRK05685 357348000595 Flagellar protein FliT; Region: FliT; cl05125 357348000596 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 357348000597 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295 357348000598 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 357348000599 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 357348000600 XdhC Rossmann domain; Region: XdhC_C; pfam13478 357348000601 amino acid transporter; Region: 2A0306; TIGR00909 357348000602 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 357348000603 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 357348000604 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348000605 active site 357348000606 phosphorylation site [posttranslational modification] 357348000607 intermolecular recognition site; other site 357348000608 dimerization interface [polypeptide binding]; other site 357348000609 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 357348000610 DNA binding residues [nucleotide binding] 357348000611 dimerization interface [polypeptide binding]; other site 357348000612 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 357348000613 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 357348000614 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 357348000615 FAD binding pocket [chemical binding]; other site 357348000616 FAD binding motif [chemical binding]; other site 357348000617 phosphate binding motif [ion binding]; other site 357348000618 beta-alpha-beta structure motif; other site 357348000619 NAD binding pocket [chemical binding]; other site 357348000620 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 357348000621 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 357348000622 putative catalytic site [active] 357348000623 putative phosphate binding site [ion binding]; other site 357348000624 putative metal binding site [ion binding]; other site 357348000625 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357348000626 Walker A motif; other site 357348000627 ATP binding site [chemical binding]; other site 357348000628 Walker B motif; other site 357348000629 arginine finger; other site 357348000630 Predicted dehydrogenase [General function prediction only]; Region: COG0579 357348000631 hydroxyglutarate oxidase; Provisional; Region: PRK11728 357348000632 High potential iron-sulfur protein; Region: HIPIP; pfam01355 357348000633 citrate-proton symporter; Provisional; Region: PRK15075 357348000634 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348000635 putative substrate translocation pore; other site 357348000636 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 357348000637 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 357348000638 peptide binding site [polypeptide binding]; other site 357348000639 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 357348000640 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348000641 dimer interface [polypeptide binding]; other site 357348000642 conserved gate region; other site 357348000643 putative PBP binding loops; other site 357348000644 ABC-ATPase subunit interface; other site 357348000645 dipeptide transporter; Provisional; Region: PRK10913 357348000646 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348000647 dimer interface [polypeptide binding]; other site 357348000648 conserved gate region; other site 357348000649 putative PBP binding loops; other site 357348000650 ABC-ATPase subunit interface; other site 357348000651 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 357348000652 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 357348000653 Walker A/P-loop; other site 357348000654 ATP binding site [chemical binding]; other site 357348000655 Q-loop/lid; other site 357348000656 ABC transporter signature motif; other site 357348000657 Walker B; other site 357348000658 D-loop; other site 357348000659 H-loop/switch region; other site 357348000660 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 357348000661 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 357348000662 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 357348000663 Walker A/P-loop; other site 357348000664 ATP binding site [chemical binding]; other site 357348000665 Q-loop/lid; other site 357348000666 ABC transporter signature motif; other site 357348000667 Walker B; other site 357348000668 D-loop; other site 357348000669 H-loop/switch region; other site 357348000670 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 357348000671 TraB family; Region: TraB; pfam01963 357348000672 Predicted membrane protein [Function unknown]; Region: COG3817 357348000673 Protein of unknown function (DUF979); Region: DUF979; pfam06166 357348000674 Protein of unknown function (DUF969); Region: DUF969; pfam06149 357348000675 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 357348000676 putative active site [active] 357348000677 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 357348000678 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 357348000679 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 357348000680 MarR family; Region: MarR_2; cl17246 357348000681 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 357348000682 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 357348000683 lytic murein transglycosylase; Provisional; Region: PRK11619 357348000684 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 357348000685 N-acetyl-D-glucosamine binding site [chemical binding]; other site 357348000686 catalytic residue [active] 357348000687 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 357348000688 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 357348000689 putative NAD(P) binding site [chemical binding]; other site 357348000690 active site 357348000691 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 357348000692 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 357348000693 putative C-terminal domain interface [polypeptide binding]; other site 357348000694 putative GSH binding site (G-site) [chemical binding]; other site 357348000695 putative dimer interface [polypeptide binding]; other site 357348000696 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 357348000697 putative N-terminal domain interface [polypeptide binding]; other site 357348000698 putative dimer interface [polypeptide binding]; other site 357348000699 putative substrate binding pocket (H-site) [chemical binding]; other site 357348000700 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 357348000701 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 357348000702 active site 357348000703 NTP binding site [chemical binding]; other site 357348000704 metal binding triad [ion binding]; metal-binding site 357348000705 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 357348000706 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503 357348000707 Killing trait; Region: RebB; pfam11747 357348000708 FlgN protein; Region: FlgN; pfam05130 357348000709 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 357348000710 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 357348000711 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 357348000712 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12626 357348000713 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 357348000714 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 357348000715 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 357348000716 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 357348000717 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 357348000718 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 357348000719 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 357348000720 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 357348000721 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 357348000722 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 357348000723 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 357348000724 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 357348000725 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 357348000726 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 357348000727 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12694 357348000728 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 357348000729 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 357348000730 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12697 357348000731 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 357348000732 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 357348000733 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 357348000734 flagellar rod assembly protein/muramidase FlgJ; Provisional; Region: flgJ; PRK12709 357348000735 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 357348000736 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 357348000737 Flagellar regulator YcgR; Region: YcgR; pfam07317 357348000738 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 357348000739 PilZ domain; Region: PilZ; pfam07238 357348000740 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06945 357348000741 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 357348000742 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 357348000743 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 357348000744 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 357348000745 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 357348000746 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348000747 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 357348000748 dimerization interface [polypeptide binding]; other site 357348000749 substrate binding pocket [chemical binding]; other site 357348000750 Chromate transporter; Region: Chromate_transp; pfam02417 357348000751 Chromate transporter; Region: Chromate_transp; pfam02417 357348000752 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 357348000753 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 357348000754 PhnA protein; Region: PhnA; pfam03831 357348000755 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 357348000756 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 357348000757 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 357348000758 trimer interface [polypeptide binding]; other site 357348000759 eyelet of channel; other site 357348000760 putative membrane protein; Region: HpnL; TIGR03476 357348000761 hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472 357348000762 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 357348000763 ligand binding site; other site 357348000764 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 357348000765 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 357348000766 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 357348000767 glutathione reductase; Validated; Region: PRK06116 357348000768 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 357348000769 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 357348000770 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 357348000771 argininosuccinate synthase; Validated; Region: PRK05370 357348000772 argininosuccinate synthase; Provisional; Region: PRK13820 357348000773 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 357348000774 metal-binding site [ion binding] 357348000775 YHS domain; Region: YHS; pfam04945 357348000776 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 357348000777 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 357348000778 Soluble P-type ATPase [General function prediction only]; Region: COG4087 357348000779 LemA family; Region: LemA; pfam04011 357348000780 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 357348000781 Repair protein; Region: Repair_PSII; pfam04536 357348000782 Repair protein; Region: Repair_PSII; pfam04536 357348000783 HlyD family secretion protein; Region: HlyD_2; pfam12700 357348000784 HlyD family secretion protein; Region: HlyD_3; pfam13437 357348000785 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 357348000786 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 357348000787 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 357348000788 Avidin family; Region: Avidin; pfam01382 357348000789 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 357348000790 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 357348000791 glutaminase active site [active] 357348000792 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 357348000793 dimer interface [polypeptide binding]; other site 357348000794 active site 357348000795 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 357348000796 dimer interface [polypeptide binding]; other site 357348000797 active site 357348000798 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 357348000799 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 357348000800 Substrate binding site; other site 357348000801 Mg++ binding site; other site 357348000802 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 357348000803 active site 357348000804 substrate binding site [chemical binding]; other site 357348000805 CoA binding site [chemical binding]; other site 357348000806 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 357348000807 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 357348000808 Ligand Binding Site [chemical binding]; other site 357348000809 Dihydroneopterin aldolase; Region: FolB; smart00905 357348000810 active site 357348000811 short chain dehydrogenase; Provisional; Region: PRK09134 357348000812 Uncharacterized conserved protein [Function unknown]; Region: COG1565 357348000813 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 357348000814 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 357348000815 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 357348000816 putative substrate binding site [chemical binding]; other site 357348000817 putative ATP binding site [chemical binding]; other site 357348000818 dimerization interface [polypeptide binding]; other site 357348000819 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221 357348000820 putative active cleft [active] 357348000821 Transcriptional regulators [Transcription]; Region: PurR; COG1609 357348000822 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 357348000823 DNA binding site [nucleotide binding] 357348000824 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 357348000825 ligand binding site [chemical binding]; other site 357348000826 dimerization interface [polypeptide binding]; other site 357348000827 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 357348000828 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 357348000829 dimer interface [polypeptide binding]; other site 357348000830 putative CheW interface [polypeptide binding]; other site 357348000831 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 357348000832 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 357348000833 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 357348000834 trimer interface [polypeptide binding]; other site 357348000835 eyelet of channel; other site 357348000836 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 357348000837 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357348000838 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348000839 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 357348000840 putative effector binding pocket; other site 357348000841 dimerization interface [polypeptide binding]; other site 357348000842 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 357348000843 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 357348000844 FMN binding site [chemical binding]; other site 357348000845 substrate binding site [chemical binding]; other site 357348000846 putative catalytic residue [active] 357348000847 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 357348000848 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 357348000849 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 357348000850 dimerization interface [polypeptide binding]; other site 357348000851 putative DNA binding site [nucleotide binding]; other site 357348000852 putative Zn2+ binding site [ion binding]; other site 357348000853 AsnC family; Region: AsnC_trans_reg; pfam01037 357348000854 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 357348000855 EamA-like transporter family; Region: EamA; pfam00892 357348000856 EamA-like transporter family; Region: EamA; pfam00892 357348000857 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 357348000858 Transposase; Region: DDE_Tnp_ISL3; pfam01610 357348000859 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 357348000860 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 357348000861 putative deacylase active site [active] 357348000862 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 357348000863 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 357348000864 active site 357348000865 catalytic residues [active] 357348000866 metal binding site [ion binding]; metal-binding site 357348000867 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 357348000868 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 357348000869 putative ligand binding site [chemical binding]; other site 357348000870 NAD binding site [chemical binding]; other site 357348000871 dimerization interface [polypeptide binding]; other site 357348000872 catalytic site [active] 357348000873 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 357348000874 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 357348000875 putative metal binding site [ion binding]; other site 357348000876 Serine hydrolase; Region: Ser_hydrolase; pfam06821 357348000877 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 357348000878 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_20; cd04679 357348000879 nudix motif; other site 357348000880 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 357348000881 Phosphoesterase family; Region: Phosphoesterase; pfam04185 357348000882 Domain of unknown function (DUF756); Region: DUF756; pfam05506 357348000883 Domain of unknown function (DUF756); Region: DUF756; pfam05506 357348000884 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 357348000885 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 357348000886 putative DNA binding site [nucleotide binding]; other site 357348000887 putative Zn2+ binding site [ion binding]; other site 357348000888 AsnC family; Region: AsnC_trans_reg; pfam01037 357348000889 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 357348000890 Predicted membrane protein [Function unknown]; Region: COG4541 357348000891 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 357348000892 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 357348000893 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 357348000894 Cu(I) binding site [ion binding]; other site 357348000895 Glyoxal oxidase N-terminus; Region: Glyoxal_oxid_N; pfam07250 357348000896 Kelch motif; Region: Kelch_6; pfam13964 357348000897 C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851 357348000898 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 357348000899 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 357348000900 dimer interface [polypeptide binding]; other site 357348000901 active site 357348000902 catalytic residue [active] 357348000903 Inclusion body protein; Region: PixA; pfam12306 357348000904 Inclusion body protein; Region: PixA; pfam12306 357348000905 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 357348000906 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 357348000907 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 357348000908 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 357348000909 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 357348000910 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 357348000911 Inward rectifier potassium channel; Region: IRK; pfam01007 357348000912 2-oxoacid ferredoxin oxidoreductase; Provisional; Region: PRK13030 357348000913 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 357348000914 dimer interface [polypeptide binding]; other site 357348000915 PYR/PP interface [polypeptide binding]; other site 357348000916 TPP binding site [chemical binding]; other site 357348000917 substrate binding site [chemical binding]; other site 357348000918 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 357348000919 TPP-binding site [chemical binding]; other site 357348000920 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 357348000921 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 357348000922 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 357348000923 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 357348000924 dimer interface [polypeptide binding]; other site 357348000925 Alkaline phosphatase homologues; Region: alkPPc; smart00098 357348000926 active site 357348000927 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 357348000928 Alkaline phosphatase homologues; Region: alkPPc; smart00098 357348000929 active site 357348000930 dimer interface [polypeptide binding]; other site 357348000931 CutC family; Region: CutC; cl01218 357348000932 biotin synthase; Region: bioB; TIGR00433 357348000933 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 357348000934 FeS/SAM binding site; other site 357348000935 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 357348000936 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 357348000937 AAA domain; Region: AAA_26; pfam13500 357348000938 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 357348000939 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 357348000940 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 357348000941 catalytic residue [active] 357348000942 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06943 357348000943 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 357348000944 inhibitor-cofactor binding pocket; inhibition site 357348000945 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348000946 catalytic residue [active] 357348000947 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 357348000948 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 357348000949 hypothetical protein; Provisional; Region: PRK01842 357348000950 short chain dehydrogenase; Provisional; Region: PRK06953 357348000951 NAD(P) binding site [chemical binding]; other site 357348000952 active site 357348000953 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 357348000954 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 357348000955 dimer interface [polypeptide binding]; other site 357348000956 active site 357348000957 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 357348000958 active site clefts [active] 357348000959 zinc binding site [ion binding]; other site 357348000960 dimer interface [polypeptide binding]; other site 357348000961 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 357348000962 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 357348000963 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 357348000964 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 357348000965 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357348000966 Walker A/P-loop; other site 357348000967 ATP binding site [chemical binding]; other site 357348000968 Q-loop/lid; other site 357348000969 ABC transporter signature motif; other site 357348000970 Walker B; other site 357348000971 D-loop; other site 357348000972 H-loop/switch region; other site 357348000973 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 357348000974 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 357348000975 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 357348000976 peptide binding site [polypeptide binding]; other site 357348000977 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 357348000978 active site 357348000979 MarR family; Region: MarR_2; cl17246 357348000980 Transcriptional regulators [Transcription]; Region: MarR; COG1846 357348000981 short chain dehydrogenase; Validated; Region: PRK08264 357348000982 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357348000983 NAD(P) binding site [chemical binding]; other site 357348000984 active site 357348000985 short chain dehydrogenase; Provisional; Region: PRK07024 357348000986 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357348000987 NAD(P) binding site [chemical binding]; other site 357348000988 active site 357348000989 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 357348000990 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 357348000991 catalytic residues [active] 357348000992 hinge region; other site 357348000993 alpha helical domain; other site 357348000994 Sporulation related domain; Region: SPOR; pfam05036 357348000995 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 357348000996 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 357348000997 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 357348000998 active site 357348000999 HIGH motif; other site 357348001000 KMSK motif region; other site 357348001001 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 357348001002 tRNA binding surface [nucleotide binding]; other site 357348001003 anticodon binding site; other site 357348001004 Domain of unknown function (DUF1840); Region: DUF1840; pfam08895 357348001005 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 357348001006 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 357348001007 substrate binding pocket [chemical binding]; other site 357348001008 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 357348001009 B12 binding site [chemical binding]; other site 357348001010 cobalt ligand [ion binding]; other site 357348001011 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 357348001012 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 357348001013 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 357348001014 Protein of unknown function (DUF3567); Region: DUF3567; pfam12091 357348001015 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 357348001016 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 357348001017 Transcriptional regulator [Transcription]; Region: IclR; COG1414 357348001018 Bacterial transcriptional regulator; Region: IclR; pfam01614 357348001019 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 357348001020 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 357348001021 enoyl-CoA hydratase; Provisional; Region: PRK07657 357348001022 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 357348001023 substrate binding site [chemical binding]; other site 357348001024 oxyanion hole (OAH) forming residues; other site 357348001025 trimer interface [polypeptide binding]; other site 357348001026 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 357348001027 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 357348001028 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 357348001029 active site 357348001030 nucleophile elbow; other site 357348001031 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 357348001032 dinuclear metal binding motif [ion binding]; other site 357348001033 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 357348001034 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 357348001035 active site 357348001036 HIGH motif; other site 357348001037 nucleotide binding site [chemical binding]; other site 357348001038 pantothenate kinase; Reviewed; Region: PRK13328 357348001039 biotin--protein ligase; Provisional; Region: PRK06955 357348001040 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 357348001041 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 357348001042 Sel1-like repeats; Region: SEL1; smart00671 357348001043 Sel1-like repeats; Region: SEL1; smart00671 357348001044 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 357348001045 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 357348001046 active site 357348001047 metal binding site [ion binding]; metal-binding site 357348001048 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 357348001049 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 357348001050 Permease; Region: Permease; pfam02405 357348001051 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 357348001052 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 357348001053 Walker A/P-loop; other site 357348001054 ATP binding site [chemical binding]; other site 357348001055 Q-loop/lid; other site 357348001056 ABC transporter signature motif; other site 357348001057 Walker B; other site 357348001058 D-loop; other site 357348001059 H-loop/switch region; other site 357348001060 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 357348001061 mce related protein; Region: MCE; pfam02470 357348001062 Protein of unknown function (DUF330); Region: DUF330; pfam03886 357348001063 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 357348001064 dimer interface [polypeptide binding]; other site 357348001065 [2Fe-2S] cluster binding site [ion binding]; other site 357348001066 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 357348001067 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 357348001068 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 357348001069 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 357348001070 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 357348001071 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 357348001072 homodimer interface [polypeptide binding]; other site 357348001073 substrate-cofactor binding pocket; other site 357348001074 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348001075 catalytic residue [active] 357348001076 hypothetical protein; Provisional; Region: PRK02047 357348001077 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 357348001078 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348001079 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 357348001080 dimerization interface [polypeptide binding]; other site 357348001081 substrate binding pocket [chemical binding]; other site 357348001082 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 357348001083 lipoate-protein ligase B; Provisional; Region: PRK14343 357348001084 lipoyl synthase; Provisional; Region: PRK05481 357348001085 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 357348001086 FeS/SAM binding site; other site 357348001087 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 357348001088 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 357348001089 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 357348001090 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357348001091 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348001092 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 357348001093 putative effector binding pocket; other site 357348001094 dimerization interface [polypeptide binding]; other site 357348001095 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 357348001096 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 357348001097 substrate binding site [chemical binding]; other site 357348001098 oxyanion hole (OAH) forming residues; other site 357348001099 trimer interface [polypeptide binding]; other site 357348001100 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 357348001101 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 357348001102 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 357348001103 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 357348001104 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 357348001105 active site 357348001106 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 357348001107 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 357348001108 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 357348001109 active site 357348001110 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 357348001111 CoA-transferase family III; Region: CoA_transf_3; pfam02515 357348001112 Protein of unknown function, DUF485; Region: DUF485; pfam04341 357348001113 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 357348001114 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 357348001115 Na binding site [ion binding]; other site 357348001116 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 357348001117 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 357348001118 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 357348001119 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357348001120 dimer interface [polypeptide binding]; other site 357348001121 phosphorylation site [posttranslational modification] 357348001122 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357348001123 ATP binding site [chemical binding]; other site 357348001124 Mg2+ binding site [ion binding]; other site 357348001125 G-X-G motif; other site 357348001126 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 357348001127 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348001128 active site 357348001129 phosphorylation site [posttranslational modification] 357348001130 intermolecular recognition site; other site 357348001131 dimerization interface [polypeptide binding]; other site 357348001132 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357348001133 Walker A motif; other site 357348001134 ATP binding site [chemical binding]; other site 357348001135 Walker B motif; other site 357348001136 arginine finger; other site 357348001137 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 357348001138 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 357348001139 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 357348001140 catalytic residues [active] 357348001141 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 357348001142 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 357348001143 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 357348001144 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 357348001145 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 357348001146 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 357348001147 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 357348001148 Membrane fusogenic activity; Region: BMFP; pfam04380 357348001149 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 357348001150 Nitrogen regulatory protein P-II; Region: P-II; smart00938 357348001151 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 357348001152 glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049 357348001153 Glutamate-cysteine ligase; Region: GshA; pfam08886 357348001154 glutathione synthetase; Provisional; Region: PRK05246 357348001155 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 357348001156 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 357348001157 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 357348001158 active pocket/dimerization site; other site 357348001159 active site 357348001160 phosphorylation site [posttranslational modification] 357348001161 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 357348001162 dimerization domain swap beta strand [polypeptide binding]; other site 357348001163 regulatory protein interface [polypeptide binding]; other site 357348001164 active site 357348001165 regulatory phosphorylation site [posttranslational modification]; other site 357348001166 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 357348001167 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 357348001168 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 357348001169 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 357348001170 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 357348001171 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 357348001172 ATP binding site [chemical binding]; other site 357348001173 substrate interface [chemical binding]; other site 357348001174 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 357348001175 C-terminal peptidase (prc); Region: prc; TIGR00225 357348001176 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 357348001177 protein binding site [polypeptide binding]; other site 357348001178 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 357348001179 Catalytic dyad [active] 357348001180 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 357348001181 catalytic core [active] 357348001182 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 357348001183 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 357348001184 active site residue [active] 357348001185 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 357348001186 GSH binding site [chemical binding]; other site 357348001187 catalytic residues [active] 357348001188 preprotein translocase subunit SecB; Validated; Region: PRK05751 357348001189 SecA binding site; other site 357348001190 Preprotein binding site; other site 357348001191 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 357348001192 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 357348001193 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 357348001194 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 357348001195 putative ADP-ribose binding site [chemical binding]; other site 357348001196 putative active site [active] 357348001197 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 357348001198 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 357348001199 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 357348001200 active site 357348001201 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 357348001202 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357348001203 S-adenosylmethionine binding site [chemical binding]; other site 357348001204 Integral membrane protein (DUF2244); Region: DUF2244; pfam10003 357348001205 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 357348001206 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140 357348001207 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 357348001208 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 357348001209 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 357348001210 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 357348001211 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 357348001212 ligand binding site [chemical binding]; other site 357348001213 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 357348001214 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 357348001215 Subunit I/III interface [polypeptide binding]; other site 357348001216 D-pathway; other site 357348001217 Subunit I/VIIc interface [polypeptide binding]; other site 357348001218 Subunit I/IV interface [polypeptide binding]; other site 357348001219 Subunit I/II interface [polypeptide binding]; other site 357348001220 Low-spin heme (heme a) binding site [chemical binding]; other site 357348001221 Subunit I/VIIa interface [polypeptide binding]; other site 357348001222 Subunit I/VIa interface [polypeptide binding]; other site 357348001223 Dimer interface; other site 357348001224 Putative water exit pathway; other site 357348001225 Binuclear center (heme a3/CuB) [ion binding]; other site 357348001226 K-pathway; other site 357348001227 Subunit I/Vb interface [polypeptide binding]; other site 357348001228 Putative proton exit pathway; other site 357348001229 Subunit I/VIb interface; other site 357348001230 Subunit I/VIc interface [polypeptide binding]; other site 357348001231 Electron transfer pathway; other site 357348001232 Subunit I/VIIIb interface [polypeptide binding]; other site 357348001233 Subunit I/VIIb interface [polypeptide binding]; other site 357348001234 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 357348001235 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 357348001236 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 357348001237 Subunit III/VIIa interface [polypeptide binding]; other site 357348001238 Phospholipid binding site [chemical binding]; other site 357348001239 Subunit I/III interface [polypeptide binding]; other site 357348001240 Subunit III/VIb interface [polypeptide binding]; other site 357348001241 Subunit III/VIa interface; other site 357348001242 Subunit III/Vb interface [polypeptide binding]; other site 357348001243 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 357348001244 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 357348001245 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 357348001246 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 357348001247 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 357348001248 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 357348001249 UbiA prenyltransferase family; Region: UbiA; pfam01040 357348001250 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 357348001251 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 357348001252 Cu(I) binding site [ion binding]; other site 357348001253 YCII-related domain; Region: YCII; cl00999 357348001254 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 357348001255 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 357348001256 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 357348001257 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 357348001258 dimer interface [polypeptide binding]; other site 357348001259 putative CheW interface [polypeptide binding]; other site 357348001260 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 357348001261 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 357348001262 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 357348001263 zinc binding site [ion binding]; other site 357348001264 putative ligand binding site [chemical binding]; other site 357348001265 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 357348001266 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 357348001267 TM-ABC transporter signature motif; other site 357348001268 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 357348001269 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357348001270 Walker A/P-loop; other site 357348001271 ATP binding site [chemical binding]; other site 357348001272 Q-loop/lid; other site 357348001273 ABC transporter signature motif; other site 357348001274 Walker B; other site 357348001275 D-loop; other site 357348001276 H-loop/switch region; other site 357348001277 DNA Polymerase Y-family; Region: PolY_like; cd03468 357348001278 active site 357348001279 DNA binding site [nucleotide binding] 357348001280 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 357348001281 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 357348001282 putative active site [active] 357348001283 putative PHP Thumb interface [polypeptide binding]; other site 357348001284 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 357348001285 generic binding surface II; other site 357348001286 generic binding surface I; other site 357348001287 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 357348001288 Fatty acid desaturase; Region: FA_desaturase; pfam00487 357348001289 putative di-iron ligands [ion binding]; other site 357348001290 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 357348001291 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 357348001292 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 357348001293 inhibitor-cofactor binding pocket; inhibition site 357348001294 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348001295 catalytic residue [active] 357348001296 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 357348001297 ABC-2 type transporter; Region: ABC2_membrane; cl17235 357348001298 thiamine ABC transporter, ATP-binding protein; Region: thiQ; TIGR01277 357348001299 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357348001300 Walker A/P-loop; other site 357348001301 ATP binding site [chemical binding]; other site 357348001302 Q-loop/lid; other site 357348001303 ABC transporter signature motif; other site 357348001304 Walker B; other site 357348001305 D-loop; other site 357348001306 H-loop/switch region; other site 357348001307 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 357348001308 Methyltransferase domain; Region: Methyltransf_31; pfam13847 357348001309 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357348001310 S-adenosylmethionine binding site [chemical binding]; other site 357348001311 Citrate synthase; Region: Citrate_synt; pfam00285 357348001312 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 357348001313 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 357348001314 citrylCoA binding site [chemical binding]; other site 357348001315 oxalacetate binding site [chemical binding]; other site 357348001316 coenzyme A binding site [chemical binding]; other site 357348001317 catalytic triad [active] 357348001318 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 357348001319 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 357348001320 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 357348001321 active site 357348001322 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 357348001323 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 357348001324 active site 357348001325 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 357348001326 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 357348001327 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 357348001328 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 357348001329 acyl-activating enzyme (AAE) consensus motif; other site 357348001330 acyl-activating enzyme (AAE) consensus motif; other site 357348001331 AMP binding site [chemical binding]; other site 357348001332 active site 357348001333 CoA binding site [chemical binding]; other site 357348001334 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Ornithine and Diaminopimelate Decarboxylases, and Related Enzymes; Region: PLPDE_III_ODC_DapDC_like; cd06810 357348001335 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 357348001336 dimer interface [polypeptide binding]; other site 357348001337 active site 357348001338 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 357348001339 catalytic residues [active] 357348001340 substrate binding site [chemical binding]; other site 357348001341 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 357348001342 active site 357348001343 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 357348001344 dinuclear metal binding motif [ion binding]; other site 357348001345 Phosphopantetheine attachment site; Region: PP-binding; cl09936 357348001346 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 357348001347 acyl-CoA synthetase; Validated; Region: PRK09192 357348001348 acyl-activating enzyme (AAE) consensus motif; other site 357348001349 active site 357348001350 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 357348001351 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348001352 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 357348001353 dimerization interface [polypeptide binding]; other site 357348001354 substrate binding pocket [chemical binding]; other site 357348001355 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 357348001356 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 357348001357 DNA-binding site [nucleotide binding]; DNA binding site 357348001358 UTRA domain; Region: UTRA; pfam07702 357348001359 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 357348001360 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 357348001361 active site 357348001362 dimer interface [polypeptide binding]; other site 357348001363 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 357348001364 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 357348001365 dimer interface [polypeptide binding]; other site 357348001366 active site 357348001367 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 357348001368 dimer interface [polypeptide binding]; other site 357348001369 active site 357348001370 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 357348001371 HPr interaction site; other site 357348001372 glycerol kinase (GK) interaction site [polypeptide binding]; other site 357348001373 active site 357348001374 phosphorylation site [posttranslational modification] 357348001375 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 357348001376 dimerization domain swap beta strand [polypeptide binding]; other site 357348001377 regulatory protein interface [polypeptide binding]; other site 357348001378 active site 357348001379 regulatory phosphorylation site [posttranslational modification]; other site 357348001380 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 357348001381 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 357348001382 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 357348001383 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 357348001384 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 357348001385 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 357348001386 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 357348001387 active site turn [active] 357348001388 phosphorylation site [posttranslational modification] 357348001389 Putative carbohydrate binding domain; Region: CHB_HEX; smart01081 357348001390 N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism]; Region: Chb; COG3525 357348001391 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 357348001392 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 357348001393 active site 357348001394 Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173 357348001395 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 357348001396 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 357348001397 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 357348001398 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 357348001399 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 357348001400 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 357348001401 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 357348001402 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 357348001403 DNA binding residues [nucleotide binding] 357348001404 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 357348001405 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 357348001406 SnoaL-like domain; Region: SnoaL_3; pfam13474 357348001407 2-isopropylmalate synthase; Validated; Region: PRK03739 357348001408 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 357348001409 active site 357348001410 catalytic residues [active] 357348001411 metal binding site [ion binding]; metal-binding site 357348001412 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357348001413 Coenzyme A binding pocket [chemical binding]; other site 357348001414 glycosyl transferase family protein; Provisional; Region: PRK08136 357348001415 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 357348001416 Molybdopterin oxidoreductase Fe4S4 domain; Region: Molybdop_Fe4S4; smart00926 357348001417 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 357348001418 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 357348001419 molybdopterin cofactor binding site; other site 357348001420 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 357348001421 molybdopterin cofactor binding site; other site 357348001422 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 357348001423 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 357348001424 [2Fe-2S] cluster binding site [ion binding]; other site 357348001425 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 357348001426 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 357348001427 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 357348001428 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 357348001429 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 357348001430 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 357348001431 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 357348001432 C-terminal domain interface [polypeptide binding]; other site 357348001433 GSH binding site (G-site) [chemical binding]; other site 357348001434 putative dimer interface [polypeptide binding]; other site 357348001435 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 357348001436 dimer interface [polypeptide binding]; other site 357348001437 N-terminal domain interface [polypeptide binding]; other site 357348001438 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 357348001439 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 357348001440 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 357348001441 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 357348001442 P loop; other site 357348001443 GTP binding site [chemical binding]; other site 357348001444 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 357348001445 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357348001446 S-adenosylmethionine binding site [chemical binding]; other site 357348001447 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 357348001448 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 357348001449 active site 357348001450 (T/H)XGH motif; other site 357348001451 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 357348001452 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 357348001453 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 357348001454 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348001455 homodimer interface [polypeptide binding]; other site 357348001456 catalytic residue [active] 357348001457 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 357348001458 putative active site [active] 357348001459 catalytic residue [active] 357348001460 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 357348001461 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 357348001462 5S rRNA interface [nucleotide binding]; other site 357348001463 CTC domain interface [polypeptide binding]; other site 357348001464 L16 interface [polypeptide binding]; other site 357348001465 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 357348001466 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 357348001467 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 357348001468 active site 357348001469 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 357348001470 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 357348001471 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 357348001472 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 357348001473 binding surface 357348001474 TPR motif; other site 357348001475 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357348001476 binding surface 357348001477 TPR motif; other site 357348001478 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357348001479 binding surface 357348001480 TPR motif; other site 357348001481 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 357348001482 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 357348001483 DNA binding site [nucleotide binding] 357348001484 catalytic residue [active] 357348001485 H2TH interface [polypeptide binding]; other site 357348001486 putative catalytic residues [active] 357348001487 turnover-facilitating residue; other site 357348001488 intercalation triad [nucleotide binding]; other site 357348001489 8OG recognition residue [nucleotide binding]; other site 357348001490 putative reading head residues; other site 357348001491 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 357348001492 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 357348001493 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 357348001494 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 357348001495 minor groove reading motif; other site 357348001496 helix-hairpin-helix signature motif; other site 357348001497 active site 357348001498 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 357348001499 DNA binding and oxoG recognition site [nucleotide binding] 357348001500 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 357348001501 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 357348001502 AAA domain; Region: AAA_18; pfam13238 357348001503 HPr kinase/phosphorylase; Provisional; Region: PRK05428 357348001504 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 357348001505 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 357348001506 Hpr binding site; other site 357348001507 active site 357348001508 homohexamer subunit interaction site [polypeptide binding]; other site 357348001509 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 357348001510 active site 357348001511 phosphorylation site [posttranslational modification] 357348001512 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 357348001513 30S subunit binding site; other site 357348001514 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 357348001515 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 357348001516 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 357348001517 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 357348001518 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 357348001519 Walker A/P-loop; other site 357348001520 ATP binding site [chemical binding]; other site 357348001521 Q-loop/lid; other site 357348001522 ABC transporter signature motif; other site 357348001523 Walker B; other site 357348001524 D-loop; other site 357348001525 H-loop/switch region; other site 357348001526 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 357348001527 OstA-like protein; Region: OstA; pfam03968 357348001528 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117 357348001529 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 357348001530 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 357348001531 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 357348001532 active site 357348001533 motif I; other site 357348001534 motif II; other site 357348001535 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 357348001536 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 357348001537 putative active site [active] 357348001538 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 357348001539 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 357348001540 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 357348001541 TrkA-N domain; Region: TrkA_N; pfam02254 357348001542 TrkA-C domain; Region: TrkA_C; pfam02080 357348001543 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 357348001544 active site 357348001545 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 357348001546 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 357348001547 nudix motif; other site 357348001548 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 357348001549 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 357348001550 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 357348001551 putative active site [active] 357348001552 putative substrate binding site [chemical binding]; other site 357348001553 putative cosubstrate binding site; other site 357348001554 catalytic site [active] 357348001555 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 357348001556 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 357348001557 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 357348001558 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 357348001559 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 357348001560 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348001561 Major Facilitator Superfamily; Region: MFS_1; pfam07690 357348001562 putative substrate translocation pore; other site 357348001563 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 357348001564 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 357348001565 dimer interface [polypeptide binding]; other site 357348001566 ssDNA binding site [nucleotide binding]; other site 357348001567 tetramer (dimer of dimers) interface [polypeptide binding]; other site 357348001568 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 357348001569 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 357348001570 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 357348001571 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 357348001572 Family description; Region: VCBS; pfam13517 357348001573 Family description; Region: VCBS; pfam13517 357348001574 Family description; Region: VCBS; pfam13517 357348001575 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 357348001576 Insecticide toxin TcdB middle/C-terminal region; Region: TcdB_toxin_midC; pfam12255 357348001577 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 357348001578 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 357348001579 Tetratricopeptide repeat; Region: TPR_12; pfam13424 357348001580 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 357348001581 phosphopeptide binding site; other site 357348001582 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 357348001583 active site 357348001584 ATP binding site [chemical binding]; other site 357348001585 substrate binding site [chemical binding]; other site 357348001586 TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903 357348001587 activation loop (A-loop); other site 357348001588 cyclase homology domain; Region: CHD; cd07302 357348001589 dimer interface [polypeptide binding]; other site 357348001590 nucleotidyl binding site; other site 357348001591 metal binding site [ion binding]; metal-binding site 357348001592 AAA ATPase domain; Region: AAA_16; pfam13191 357348001593 ribosomal natural product, two-chain TOMM family; Region: RNP_Burkhold; TIGR03795 357348001594 ribosomal natural product, two-chain TOMM family; Region: RNP_Burkhold; TIGR03795 357348001595 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 357348001596 YcaO-like family; Region: YcaO; pfam02624 357348001597 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 357348001598 aldolase II superfamily protein; Provisional; Region: PRK07044 357348001599 intersubunit interface [polypeptide binding]; other site 357348001600 active site 357348001601 Zn2+ binding site [ion binding]; other site 357348001602 PAS domain; Region: PAS; smart00091 357348001603 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 357348001604 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 357348001605 metal binding site [ion binding]; metal-binding site 357348001606 active site 357348001607 I-site; other site 357348001608 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 357348001609 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 357348001610 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 357348001611 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 357348001612 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357348001613 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 357348001614 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 357348001615 Substrate binding site; other site 357348001616 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 357348001617 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 357348001618 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357348001619 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 357348001620 putative ADP-binding pocket [chemical binding]; other site 357348001621 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 357348001622 active site 357348001623 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 357348001624 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357348001625 Walker A motif; other site 357348001626 ATP binding site [chemical binding]; other site 357348001627 Walker B motif; other site 357348001628 arginine finger; other site 357348001629 exosortase A system-associated hydrolase 1; Region: hydr1_PEP; TIGR03100 357348001630 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 357348001631 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 357348001632 Domain of unknown function (DUF1839); Region: DUF1839; pfam08893 357348001633 Gly_His_Pro_Ser_Thr_tRNA synthetase class II core domain. This domain is the core catalytic domain of tRNA synthetases of the subgroup containing glycyl, histidyl, prolyl, seryl and threonyl tRNA synthetases. It is primarily responsible for ATP-dependent...; Region: Gly_His_Pro_Ser_Thr_tRS_core; cd00670 357348001634 dimer interface [polypeptide binding]; other site 357348001635 motif 1; other site 357348001636 active site 357348001637 motif 2; other site 357348001638 motif 3; other site 357348001639 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 357348001640 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 357348001641 active site 357348001642 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 357348001643 active site 357348001644 acyl carrier protein; Provisional; Region: PRK07081 357348001645 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 357348001646 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 357348001647 ligand binding site [chemical binding]; other site 357348001648 flexible hinge region; other site 357348001649 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 357348001650 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 357348001651 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 357348001652 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 357348001653 non-specific DNA interactions [nucleotide binding]; other site 357348001654 DNA binding site [nucleotide binding] 357348001655 sequence specific DNA binding site [nucleotide binding]; other site 357348001656 putative cAMP binding site [chemical binding]; other site 357348001657 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 357348001658 Bacterial sugar transferase; Region: Bac_transf; pfam02397 357348001659 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 357348001660 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 357348001661 SLBB domain; Region: SLBB; pfam10531 357348001662 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 357348001663 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 357348001664 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357348001665 CHRD domain; Region: CHRD; pfam07452 357348001666 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 357348001667 EcsC protein family; Region: EcsC; pfam12787 357348001668 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348001669 Major Facilitator Superfamily; Region: MFS_1; pfam07690 357348001670 putative substrate translocation pore; other site 357348001671 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348001672 Transcriptional regulators [Transcription]; Region: MarR; COG1846 357348001673 MarR family; Region: MarR; pfam01047 357348001674 MarR family; Region: MarR_2; cl17246 357348001675 intracellular protease, PfpI family; Region: PfpI; TIGR01382 357348001676 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 357348001677 conserved cys residue [active] 357348001678 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 357348001679 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 357348001680 dimer interface [polypeptide binding]; other site 357348001681 active site 357348001682 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 357348001683 substrate binding site [chemical binding]; other site 357348001684 catalytic residue [active] 357348001685 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 357348001686 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 357348001687 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 357348001688 putative active site [active] 357348001689 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 357348001690 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 357348001691 active site 357348001692 putative substrate binding pocket [chemical binding]; other site 357348001693 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 357348001694 homotrimer interaction site [polypeptide binding]; other site 357348001695 putative active site [active] 357348001696 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 357348001697 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 357348001698 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 357348001699 threonine dehydratase; Reviewed; Region: PRK09224 357348001700 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 357348001701 tetramer interface [polypeptide binding]; other site 357348001702 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348001703 catalytic residue [active] 357348001704 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 357348001705 putative Ile/Val binding site [chemical binding]; other site 357348001706 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 357348001707 putative Ile/Val binding site [chemical binding]; other site 357348001708 Protein of unknown function (DUF3683); Region: DUF3683; pfam12447 357348001709 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 357348001710 FAD binding domain; Region: FAD_binding_4; pfam01565 357348001711 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 357348001712 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 357348001713 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 357348001714 Cysteine-rich domain; Region: CCG; pfam02754 357348001715 Domain of unknown function (DUF3400); Region: DUF3400; pfam11880 357348001716 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 357348001717 nucleotide binding site/active site [active] 357348001718 HIT family signature motif; other site 357348001719 catalytic residue [active] 357348001720 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 357348001721 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 357348001722 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357348001723 S-adenosylmethionine binding site [chemical binding]; other site 357348001724 Tim44-like domain; Region: Tim44; pfam04280 357348001725 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 357348001726 SCP-2 sterol transfer family; Region: SCP2; pfam02036 357348001727 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 357348001728 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 357348001729 thiopurine S-methyltransferase, Se/Te detoxification family; Region: TMPT_Se_Te; TIGR03840 357348001730 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 357348001731 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 357348001732 Uncharacterized conserved protein [Function unknown]; Region: COG2928 357348001733 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 357348001734 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 357348001735 dimer interface [polypeptide binding]; other site 357348001736 anticodon binding site; other site 357348001737 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 357348001738 homodimer interface [polypeptide binding]; other site 357348001739 motif 1; other site 357348001740 active site 357348001741 motif 2; other site 357348001742 GAD domain; Region: GAD; pfam02938 357348001743 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 357348001744 motif 3; other site 357348001745 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 357348001746 nudix motif; other site 357348001747 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 357348001748 PLD-like domain; Region: PLDc_2; pfam13091 357348001749 putative active site [active] 357348001750 catalytic site [active] 357348001751 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 357348001752 PLD-like domain; Region: PLDc_2; pfam13091 357348001753 putative active site [active] 357348001754 catalytic site [active] 357348001755 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 357348001756 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 357348001757 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 357348001758 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 357348001759 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 357348001760 FAD binding site [chemical binding]; other site 357348001761 substrate binding site [chemical binding]; other site 357348001762 catalytic residues [active] 357348001763 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 357348001764 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 357348001765 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 357348001766 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 357348001767 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 357348001768 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 357348001769 substrate binding site [chemical binding]; other site 357348001770 oxyanion hole (OAH) forming residues; other site 357348001771 trimer interface [polypeptide binding]; other site 357348001772 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 357348001773 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 357348001774 dimer interface [polypeptide binding]; other site 357348001775 active site 357348001776 enoyl-CoA hydratase; Provisional; Region: PRK06688 357348001777 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 357348001778 substrate binding site [chemical binding]; other site 357348001779 oxyanion hole (OAH) forming residues; other site 357348001780 trimer interface [polypeptide binding]; other site 357348001781 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 357348001782 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 357348001783 conserved hypothetical protein; Region: nitr_red_assoc; TIGR02664 357348001784 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 357348001785 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 357348001786 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 357348001787 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357348001788 Walker A/P-loop; other site 357348001789 ATP binding site [chemical binding]; other site 357348001790 Q-loop/lid; other site 357348001791 ABC transporter signature motif; other site 357348001792 Walker B; other site 357348001793 D-loop; other site 357348001794 H-loop/switch region; other site 357348001795 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 357348001796 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 357348001797 Substrate binding site; other site 357348001798 metal-binding site 357348001799 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 357348001800 Phosphotransferase enzyme family; Region: APH; pfam01636 357348001801 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 357348001802 Organic solvent tolerance protein; Region: OstA_C; pfam04453 357348001803 SurA N-terminal domain; Region: SurA_N; pfam09312 357348001804 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 357348001805 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 357348001806 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 357348001807 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK01909 357348001808 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 357348001809 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 357348001810 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 357348001811 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 357348001812 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 357348001813 dimer interface [polypeptide binding]; other site 357348001814 active site 357348001815 metal binding site [ion binding]; metal-binding site 357348001816 glutathione binding site [chemical binding]; other site 357348001817 Protein of unknown function DUF45; Region: DUF45; pfam01863 357348001818 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 357348001819 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 357348001820 putative acyl-acceptor binding pocket; other site 357348001821 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 357348001822 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 357348001823 active site 357348001824 motif I; other site 357348001825 motif II; other site 357348001826 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 357348001827 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 357348001828 dimer interface [polypeptide binding]; other site 357348001829 motif 1; other site 357348001830 active site 357348001831 motif 2; other site 357348001832 motif 3; other site 357348001833 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 357348001834 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 357348001835 putative active site [active] 357348001836 catalytic triad [active] 357348001837 putative dimer interface [polypeptide binding]; other site 357348001838 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 357348001839 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 357348001840 Transporter associated domain; Region: CorC_HlyC; smart01091 357348001841 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 357348001842 putative active site pocket [active] 357348001843 dimerization interface [polypeptide binding]; other site 357348001844 putative catalytic residue [active] 357348001845 unkown domain/putative metalloprotease fusion protein; Provisional; Region: PRK13963 357348001846 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 357348001847 PhoH-like protein; Region: PhoH; pfam02562 357348001848 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 357348001849 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 357348001850 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 357348001851 FeS/SAM binding site; other site 357348001852 TRAM domain; Region: TRAM; pfam01938 357348001853 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357348001854 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348001855 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 357348001856 putative effector binding pocket; other site 357348001857 dimerization interface [polypeptide binding]; other site 357348001858 MFS transport protein AraJ; Provisional; Region: PRK10091 357348001859 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348001860 putative substrate translocation pore; other site 357348001861 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 357348001862 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 357348001863 non-specific DNA binding site [nucleotide binding]; other site 357348001864 salt bridge; other site 357348001865 sequence-specific DNA binding site [nucleotide binding]; other site 357348001866 Cupin domain; Region: Cupin_2; pfam07883 357348001867 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 357348001868 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 357348001869 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 357348001870 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 357348001871 motif II; other site 357348001872 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 357348001873 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 357348001874 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 357348001875 active site 357348001876 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 357348001877 dimer interface [polypeptide binding]; other site 357348001878 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 357348001879 Ligand Binding Site [chemical binding]; other site 357348001880 Molecular Tunnel; other site 357348001881 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 357348001882 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 357348001883 hinge; other site 357348001884 active site 357348001885 5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128 357348001886 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 357348001887 putative active site [active] 357348001888 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 357348001889 homotrimer interaction site [polypeptide binding]; other site 357348001890 putative active site [active] 357348001891 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 357348001892 amphipathic channel; other site 357348001893 Asn-Pro-Ala signature motifs; other site 357348001894 glycerol kinase; Provisional; Region: glpK; PRK00047 357348001895 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 357348001896 N- and C-terminal domain interface [polypeptide binding]; other site 357348001897 active site 357348001898 MgATP binding site [chemical binding]; other site 357348001899 catalytic site [active] 357348001900 metal binding site [ion binding]; metal-binding site 357348001901 glycerol binding site [chemical binding]; other site 357348001902 homotetramer interface [polypeptide binding]; other site 357348001903 homodimer interface [polypeptide binding]; other site 357348001904 FBP binding site [chemical binding]; other site 357348001905 protein IIAGlc interface [polypeptide binding]; other site 357348001906 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 357348001907 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 357348001908 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 357348001909 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 357348001910 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 357348001911 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 357348001912 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 357348001913 dinuclear metal binding motif [ion binding]; other site 357348001914 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 357348001915 ATP binding site [chemical binding]; other site 357348001916 Mg++ binding site [ion binding]; other site 357348001917 motif III; other site 357348001918 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 357348001919 nucleotide binding region [chemical binding]; other site 357348001920 ATP-binding site [chemical binding]; other site 357348001921 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 357348001922 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 357348001923 Cytochrome c; Region: Cytochrom_C; pfam00034 357348001924 Cytochrome c; Region: Cytochrom_C; cl11414 357348001925 Cytochrome c; Region: Cytochrom_C; cl11414 357348001926 Copper resistance protein D; Region: CopD; pfam05425 357348001927 galactonate dehydratase; Provisional; Region: PRK14017 357348001928 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 357348001929 putative active site pocket [active] 357348001930 putative metal binding site [ion binding]; other site 357348001931 Uncharacterized conserved protein [Function unknown]; Region: COG3791 357348001932 Domain of unknown function (DUF4377); Region: DUF4377; pfam14302 357348001933 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 357348001934 active site 357348001935 metal binding site [ion binding]; metal-binding site 357348001936 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 357348001937 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 357348001938 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 357348001939 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 357348001940 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357348001941 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 357348001942 linker region; other site 357348001943 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357348001944 ATP binding site [chemical binding]; other site 357348001945 Mg2+ binding site [ion binding]; other site 357348001946 G-X-G motif; other site 357348001947 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 357348001948 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348001949 active site 357348001950 phosphorylation site [posttranslational modification] 357348001951 intermolecular recognition site; other site 357348001952 dimerization interface [polypeptide binding]; other site 357348001953 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 357348001954 Zn2+ binding site [ion binding]; other site 357348001955 Mg2+ binding site [ion binding]; other site 357348001956 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 357348001957 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 357348001958 PAS domain; Region: PAS_9; pfam13426 357348001959 putative active site [active] 357348001960 heme pocket [chemical binding]; other site 357348001961 HAMP domain; Region: HAMP; pfam00672 357348001962 dimerization interface [polypeptide binding]; other site 357348001963 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 357348001964 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 357348001965 dimer interface [polypeptide binding]; other site 357348001966 putative CheW interface [polypeptide binding]; other site 357348001967 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 357348001968 FAD binding domain; Region: FAD_binding_4; pfam01565 357348001969 Cholesterol oxidase, substrate-binding; Region: Chol_subst-bind; pfam09129 357348001970 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 357348001971 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 357348001972 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 357348001973 dimerization interface [polypeptide binding]; other site 357348001974 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 357348001975 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 357348001976 active site residue [active] 357348001977 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 357348001978 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 357348001979 Walker A/P-loop; other site 357348001980 ATP binding site [chemical binding]; other site 357348001981 Q-loop/lid; other site 357348001982 ABC transporter signature motif; other site 357348001983 Walker B; other site 357348001984 D-loop; other site 357348001985 H-loop/switch region; other site 357348001986 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 357348001987 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 357348001988 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348001989 dimer interface [polypeptide binding]; other site 357348001990 conserved gate region; other site 357348001991 putative PBP binding loops; other site 357348001992 ABC-ATPase subunit interface; other site 357348001993 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348001994 dimer interface [polypeptide binding]; other site 357348001995 ABC-ATPase subunit interface; other site 357348001996 putative PBP binding loops; other site 357348001997 Erythromycin esterase; Region: Erythro_esteras; pfam05139 357348001998 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 357348001999 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 357348002000 active site 357348002001 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 357348002002 active site 357348002003 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 357348002004 Transglycosylase; Region: Transgly; cl17702 357348002005 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 357348002006 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 357348002007 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 357348002008 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 357348002009 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 357348002010 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 357348002011 D-pathway; other site 357348002012 Putative ubiquinol binding site [chemical binding]; other site 357348002013 Low-spin heme (heme b) binding site [chemical binding]; other site 357348002014 Putative water exit pathway; other site 357348002015 Binuclear center (heme o3/CuB) [ion binding]; other site 357348002016 K-pathway; other site 357348002017 Putative proton exit pathway; other site 357348002018 Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_2; cd02865 357348002019 Subunit I/III interface [polypeptide binding]; other site 357348002020 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 357348002021 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 357348002022 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 357348002023 Cytochrome c; Region: Cytochrom_C; pfam00034 357348002024 thiamine pyrophosphate protein; Provisional; Region: PRK08273 357348002025 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 357348002026 PYR/PP interface [polypeptide binding]; other site 357348002027 dimer interface [polypeptide binding]; other site 357348002028 tetramer interface [polypeptide binding]; other site 357348002029 TPP binding site [chemical binding]; other site 357348002030 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 357348002031 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 357348002032 TPP-binding site [chemical binding]; other site 357348002033 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 357348002034 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 357348002035 metal binding site [ion binding]; metal-binding site 357348002036 substrate binding pocket [chemical binding]; other site 357348002037 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 357348002038 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 357348002039 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 357348002040 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 357348002041 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 357348002042 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 357348002043 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 357348002044 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 357348002045 active site 357348002046 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357348002047 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348002048 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 357348002049 putative effector binding pocket; other site 357348002050 putative dimerization interface [polypeptide binding]; other site 357348002051 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357348002052 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357348002053 dimer interface [polypeptide binding]; other site 357348002054 phosphorylation site [posttranslational modification] 357348002055 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357348002056 ATP binding site [chemical binding]; other site 357348002057 Mg2+ binding site [ion binding]; other site 357348002058 G-X-G motif; other site 357348002059 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348002060 Response regulator receiver domain; Region: Response_reg; pfam00072 357348002061 active site 357348002062 phosphorylation site [posttranslational modification] 357348002063 intermolecular recognition site; other site 357348002064 dimerization interface [polypeptide binding]; other site 357348002065 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 357348002066 BetR domain; Region: BetR; pfam08667 357348002067 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 357348002068 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348002069 active site 357348002070 phosphorylation site [posttranslational modification] 357348002071 intermolecular recognition site; other site 357348002072 dimerization interface [polypeptide binding]; other site 357348002073 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 357348002074 MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937 357348002075 Abortive infection C-terminus; Region: Abi_C; pfam14355 357348002076 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 357348002077 active site 357348002078 DNA binding site [nucleotide binding] 357348002079 Int/Topo IB signature motif; other site 357348002080 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348002081 putative substrate translocation pore; other site 357348002082 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 357348002083 HAMP domain; Region: HAMP; pfam00672 357348002084 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357348002085 dimer interface [polypeptide binding]; other site 357348002086 phosphorylation site [posttranslational modification] 357348002087 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357348002088 ATP binding site [chemical binding]; other site 357348002089 Mg2+ binding site [ion binding]; other site 357348002090 G-X-G motif; other site 357348002091 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 357348002092 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348002093 active site 357348002094 phosphorylation site [posttranslational modification] 357348002095 intermolecular recognition site; other site 357348002096 dimerization interface [polypeptide binding]; other site 357348002097 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357348002098 DNA binding site [nucleotide binding] 357348002099 recombinase A; Provisional; Region: recA; PRK09354 357348002100 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 357348002101 hexamer interface [polypeptide binding]; other site 357348002102 Walker A motif; other site 357348002103 ATP binding site [chemical binding]; other site 357348002104 Walker B motif; other site 357348002105 recombination regulator RecX; Provisional; Region: recX; PRK14136 357348002106 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 357348002107 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 357348002108 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 357348002109 CoA-ligase; Region: Ligase_CoA; pfam00549 357348002110 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 357348002111 CoA binding domain; Region: CoA_binding; smart00881 357348002112 CoA-ligase; Region: Ligase_CoA; pfam00549 357348002113 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 357348002114 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 357348002115 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 357348002116 O-Antigen ligase; Region: Wzy_C; pfam04932 357348002117 Domain of unknown function (DUF3366); Region: DUF3366; pfam11846 357348002118 hypothetical protein; Provisional; Region: PRK11667 357348002119 Gram-negative bacterial tonB protein; Region: TonB; cl10048 357348002120 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 357348002121 trimer interface [polypeptide binding]; other site 357348002122 dimer interface [polypeptide binding]; other site 357348002123 putative active site [active] 357348002124 Peptidase family M48; Region: Peptidase_M48; pfam01435 357348002125 Protein of unknown function (DUF2946); Region: DUF2944; pfam11161 357348002126 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 357348002127 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 357348002128 SnoaL-like domain; Region: SnoaL_3; pfam13474 357348002129 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 357348002130 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 357348002131 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 357348002132 putative active site [active] 357348002133 Zinc-finger domain; Region: zf-CHCC; cl01821 357348002134 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 357348002135 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 357348002136 homodimer interface [polypeptide binding]; other site 357348002137 substrate-cofactor binding pocket; other site 357348002138 catalytic residue [active] 357348002139 AzlC protein; Region: AzlC; cl00570 357348002140 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 357348002141 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 357348002142 Phosphoglycerate kinase; Region: PGK; pfam00162 357348002143 substrate binding site [chemical binding]; other site 357348002144 hinge regions; other site 357348002145 ADP binding site [chemical binding]; other site 357348002146 catalytic site [active] 357348002147 pyruvate kinase; Provisional; Region: PRK05826 357348002148 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 357348002149 domain interfaces; other site 357348002150 active site 357348002151 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 357348002152 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 357348002153 intersubunit interface [polypeptide binding]; other site 357348002154 active site 357348002155 zinc binding site [ion binding]; other site 357348002156 Na+ binding site [ion binding]; other site 357348002157 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 357348002158 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 357348002159 ATP binding site [chemical binding]; other site 357348002160 active site 357348002161 substrate binding site [chemical binding]; other site 357348002162 AIR carboxylase; Region: AIRC; pfam00731 357348002163 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 357348002164 ATP-grasp domain; Region: ATP-grasp; pfam02222 357348002165 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 357348002166 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 357348002167 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 357348002168 active site 357348002169 catalytic triad [active] 357348002170 oxyanion hole [active] 357348002171 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 357348002172 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 357348002173 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 357348002174 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 357348002175 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348002176 active site 357348002177 phosphorylation site [posttranslational modification] 357348002178 intermolecular recognition site; other site 357348002179 dimerization interface [polypeptide binding]; other site 357348002180 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357348002181 DNA binding site [nucleotide binding] 357348002182 sensor protein QseC; Provisional; Region: PRK10337 357348002183 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357348002184 ATP binding site [chemical binding]; other site 357348002185 Mg2+ binding site [ion binding]; other site 357348002186 G-X-G motif; other site 357348002187 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 357348002188 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 357348002189 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 357348002190 protein binding site [polypeptide binding]; other site 357348002191 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 357348002192 protein binding site [polypeptide binding]; other site 357348002193 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 357348002194 Domain of unknown function (DUF427); Region: DUF427; pfam04248 357348002195 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 357348002196 hydrophobic ligand binding site; other site 357348002197 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 357348002198 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 357348002199 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 357348002200 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 357348002201 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 357348002202 HlyD family secretion protein; Region: HlyD_3; pfam13437 357348002203 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 357348002204 Protein export membrane protein; Region: SecD_SecF; cl14618 357348002205 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 357348002206 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 357348002207 xanthine permease; Region: pbuX; TIGR03173 357348002208 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 357348002209 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 357348002210 nucleotide binding site [chemical binding]; other site 357348002211 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 357348002212 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 357348002213 conserved cys residue [active] 357348002214 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357348002215 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357348002216 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 357348002217 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 357348002218 substrate binding site [chemical binding]; other site 357348002219 catalytic Zn binding site [ion binding]; other site 357348002220 NAD binding site [chemical binding]; other site 357348002221 structural Zn binding site [ion binding]; other site 357348002222 dimer interface [polypeptide binding]; other site 357348002223 S-formylglutathione hydrolase; Region: PLN02442 357348002224 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 357348002225 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 357348002226 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 357348002227 dimer interface [polypeptide binding]; other site 357348002228 putative PBP binding regions; other site 357348002229 ABC-ATPase subunit interface; other site 357348002230 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 357348002231 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 357348002232 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 357348002233 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 357348002234 metal binding site [ion binding]; metal-binding site 357348002235 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 357348002236 metal binding site 2 [ion binding]; metal-binding site 357348002237 putative DNA binding helix; other site 357348002238 metal binding site 1 [ion binding]; metal-binding site 357348002239 dimer interface [polypeptide binding]; other site 357348002240 structural Zn2+ binding site [ion binding]; other site 357348002241 sorbitol dehydrogenase; Provisional; Region: PRK07067 357348002242 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357348002243 NAD(P) binding site [chemical binding]; other site 357348002244 active site 357348002245 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 357348002246 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 357348002247 substrate binding site [chemical binding]; other site 357348002248 ATP binding site [chemical binding]; other site 357348002249 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 357348002250 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 357348002251 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 357348002252 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 357348002253 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 357348002254 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348002255 dimer interface [polypeptide binding]; other site 357348002256 conserved gate region; other site 357348002257 putative PBP binding loops; other site 357348002258 ABC-ATPase subunit interface; other site 357348002259 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 357348002260 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348002261 dimer interface [polypeptide binding]; other site 357348002262 conserved gate region; other site 357348002263 putative PBP binding loops; other site 357348002264 ABC-ATPase subunit interface; other site 357348002265 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 357348002266 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 357348002267 active site 357348002268 motif I; other site 357348002269 motif II; other site 357348002270 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 357348002271 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 357348002272 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 357348002273 Walker A/P-loop; other site 357348002274 ATP binding site [chemical binding]; other site 357348002275 Q-loop/lid; other site 357348002276 ABC transporter signature motif; other site 357348002277 Walker B; other site 357348002278 D-loop; other site 357348002279 H-loop/switch region; other site 357348002280 TOBE domain; Region: TOBE; pfam03459 357348002281 TOBE domain; Region: TOBE_2; pfam08402 357348002282 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 357348002283 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357348002284 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348002285 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 357348002286 putative effector binding pocket; other site 357348002287 putative dimerization interface [polypeptide binding]; other site 357348002288 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 357348002289 Beta-lactamase; Region: Beta-lactamase; pfam00144 357348002290 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 357348002291 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348002292 putative substrate translocation pore; other site 357348002293 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 357348002294 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 357348002295 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 357348002296 N- and C-terminal domain interface [polypeptide binding]; other site 357348002297 D-xylulose kinase; Region: XylB; TIGR01312 357348002298 active site 357348002299 MgATP binding site [chemical binding]; other site 357348002300 catalytic site [active] 357348002301 metal binding site [ion binding]; metal-binding site 357348002302 xylulose binding site [chemical binding]; other site 357348002303 homodimer interface [polypeptide binding]; other site 357348002304 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 357348002305 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 357348002306 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 357348002307 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357348002308 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348002309 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 357348002310 dimerization interface [polypeptide binding]; other site 357348002311 benzoylformate decarboxylase; Reviewed; Region: PRK07092 357348002312 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 357348002313 PYR/PP interface [polypeptide binding]; other site 357348002314 dimer interface [polypeptide binding]; other site 357348002315 TPP binding site [chemical binding]; other site 357348002316 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 357348002317 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 357348002318 TPP-binding site [chemical binding]; other site 357348002319 dimer interface [polypeptide binding]; other site 357348002320 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 357348002321 Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105 357348002322 NAD(P) binding site [chemical binding]; other site 357348002323 catalytic residues [active] 357348002324 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 357348002325 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 357348002326 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 357348002327 benzoate transport; Region: 2A0115; TIGR00895 357348002328 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348002329 putative substrate translocation pore; other site 357348002330 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348002331 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 357348002332 Kynureninase [Amino acid transport and metabolism]; Region: COG3844 357348002333 kynureninase; Region: kynureninase; TIGR01814 357348002334 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 357348002335 catalytic residue [active] 357348002336 arylformamidase; Region: trp_arylform; TIGR03035 357348002337 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 357348002338 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 357348002339 putative DNA binding site [nucleotide binding]; other site 357348002340 putative Zn2+ binding site [ion binding]; other site 357348002341 AsnC family; Region: AsnC_trans_reg; pfam01037 357348002342 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 357348002343 methionine sulfoxide reductase A; Provisional; Region: PRK14054 357348002344 Protein of unknown function DUF72; Region: DUF72; pfam01904 357348002345 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 357348002346 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357348002347 S-adenosylmethionine binding site [chemical binding]; other site 357348002348 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 357348002349 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 357348002350 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 357348002351 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 357348002352 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 357348002353 putative ATP binding site [chemical binding]; other site 357348002354 putative substrate interface [chemical binding]; other site 357348002355 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 357348002356 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 357348002357 catalytic residues [active] 357348002358 Pirin-related protein [General function prediction only]; Region: COG1741 357348002359 Pirin; Region: Pirin; pfam02678 357348002360 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 357348002361 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 357348002362 EamA-like transporter family; Region: EamA; pfam00892 357348002363 AMIN domain; Region: AMIN; pfam11741 357348002364 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 357348002365 active site 357348002366 metal binding site [ion binding]; metal-binding site 357348002367 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 357348002368 epoxyqueuosine reductase; Region: TIGR00276 357348002369 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 357348002370 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 357348002371 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 357348002372 DNA binding site [nucleotide binding] 357348002373 active site 357348002374 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 357348002375 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 357348002376 active site 357348002377 Int/Topo IB signature motif; other site 357348002378 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 357348002379 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 357348002380 acyl-activating enzyme (AAE) consensus motif; other site 357348002381 AMP binding site [chemical binding]; other site 357348002382 active site 357348002383 CoA binding site [chemical binding]; other site 357348002384 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 357348002385 putative deacylase active site [active] 357348002386 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 357348002387 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 357348002388 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 357348002389 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 357348002390 FAD binding domain; Region: FAD_binding_4; pfam01565 357348002391 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 357348002392 ornithine carbamoyltransferase; Provisional; Region: PRK00779 357348002393 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 357348002394 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 357348002395 Protein of unknown function (DUF3579); Region: DUF3579; pfam12112 357348002396 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 357348002397 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 357348002398 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 357348002399 Uncharacterized conserved protein [Function unknown]; Region: COG2912 357348002400 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 357348002401 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 357348002402 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357348002403 NAD(P) binding site [chemical binding]; other site 357348002404 active site 357348002405 adenylate kinase; Reviewed; Region: adk; PRK00279 357348002406 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 357348002407 AMP-binding site [chemical binding]; other site 357348002408 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 357348002409 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 357348002410 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 357348002411 Ligand binding site; other site 357348002412 oligomer interface; other site 357348002413 Uncharacterized conserved protein [Function unknown]; Region: COG2835 357348002414 tetraacyldisaccharide 4'-kinase; Provisional; Region: PRK01906 357348002415 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 357348002416 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 357348002417 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 357348002418 generic binding surface II; other site 357348002419 generic binding surface I; other site 357348002420 superoxide dismutase; Provisional; Region: PRK10543 357348002421 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 357348002422 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 357348002423 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 357348002424 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 357348002425 Chromate transporter; Region: Chromate_transp; pfam02417 357348002426 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 357348002427 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 357348002428 ligand binding site [chemical binding]; other site 357348002429 flexible hinge region; other site 357348002430 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 357348002431 putative switch regulator; other site 357348002432 non-specific DNA interactions [nucleotide binding]; other site 357348002433 DNA binding site [nucleotide binding] 357348002434 sequence specific DNA binding site [nucleotide binding]; other site 357348002435 putative cAMP binding site [chemical binding]; other site 357348002436 Predicted membrane protein [Function unknown]; Region: COG4539 357348002437 2-dehydropantoate 2-reductase; Provisional; Region: PRK08229 357348002438 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 357348002439 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 357348002440 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357348002441 S-adenosylmethionine binding site [chemical binding]; other site 357348002442 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 357348002443 putative transporter; Provisional; Region: PRK10504 357348002444 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348002445 putative substrate translocation pore; other site 357348002446 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 357348002447 Helix-turn-helix domain; Region: HTH_17; pfam12728 357348002448 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 357348002449 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102 357348002450 dimer interface [polypeptide binding]; other site 357348002451 active site 357348002452 oxalacetate/citrate binding site [chemical binding]; other site 357348002453 citrylCoA binding site [chemical binding]; other site 357348002454 coenzyme A binding site [chemical binding]; other site 357348002455 catalytic triad [active] 357348002456 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 357348002457 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 357348002458 DNA-binding site [nucleotide binding]; DNA binding site 357348002459 UTRA domain; Region: UTRA; pfam07702 357348002460 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 357348002461 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 357348002462 active site 357348002463 catalytic tetrad [active] 357348002464 elongation factor G; Reviewed; Region: PRK00007 357348002465 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 357348002466 G1 box; other site 357348002467 putative GEF interaction site [polypeptide binding]; other site 357348002468 GTP/Mg2+ binding site [chemical binding]; other site 357348002469 Switch I region; other site 357348002470 G2 box; other site 357348002471 G3 box; other site 357348002472 Switch II region; other site 357348002473 G4 box; other site 357348002474 G5 box; other site 357348002475 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 357348002476 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 357348002477 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 357348002478 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 357348002479 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 357348002480 pseudouridine synthase; Region: TIGR00093 357348002481 active site 357348002482 isocitrate dehydrogenase; Validated; Region: PRK07362 357348002483 isocitrate dehydrogenase; Reviewed; Region: PRK07006 357348002484 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 357348002485 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 357348002486 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 357348002487 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 357348002488 DNA-binding site [nucleotide binding]; DNA binding site 357348002489 RNA-binding motif; other site 357348002490 Uncharacterized conserved protein [Function unknown]; Region: COG2127 357348002491 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 357348002492 Clp amino terminal domain; Region: Clp_N; pfam02861 357348002493 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357348002494 Walker A motif; other site 357348002495 ATP binding site [chemical binding]; other site 357348002496 Walker B motif; other site 357348002497 arginine finger; other site 357348002498 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357348002499 Walker A motif; other site 357348002500 ATP binding site [chemical binding]; other site 357348002501 Walker B motif; other site 357348002502 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 357348002503 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 357348002504 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 357348002505 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 357348002506 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 357348002507 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 357348002508 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 357348002509 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 357348002510 trimer interface [polypeptide binding]; other site 357348002511 active site 357348002512 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 357348002513 Flavoprotein; Region: Flavoprotein; pfam02441 357348002514 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 357348002515 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 357348002516 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 357348002517 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 357348002518 active site 357348002519 HIGH motif; other site 357348002520 nucleotide binding site [chemical binding]; other site 357348002521 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 357348002522 active site 357348002523 KMSKS motif; other site 357348002524 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 357348002525 tRNA binding surface [nucleotide binding]; other site 357348002526 anticodon binding site; other site 357348002527 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 357348002528 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 357348002529 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 357348002530 active site 357348002531 Riboflavin kinase; Region: Flavokinase; smart00904 357348002532 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 357348002533 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 357348002534 active site 357348002535 substrate binding site [chemical binding]; other site 357348002536 cosubstrate binding site; other site 357348002537 catalytic site [active] 357348002538 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 357348002539 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357348002540 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 357348002541 Mechanosensitive ion channel; Region: MS_channel; pfam00924 357348002542 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 357348002543 Fatty acid desaturase; Region: FA_desaturase; pfam00487 357348002544 Di-iron ligands [ion binding]; other site 357348002545 Transposase; Region: DDE_Tnp_ISL3; pfam01610 357348002546 quinolinate synthetase; Provisional; Region: PRK09375 357348002547 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06978 357348002548 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 357348002549 dimerization interface [polypeptide binding]; other site 357348002550 active site 357348002551 L-aspartate oxidase; Provisional; Region: PRK09077 357348002552 L-aspartate oxidase; Provisional; Region: PRK06175 357348002553 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 357348002554 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 357348002555 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 357348002556 hypothetical protein; Reviewed; Region: PRK00024 357348002557 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 357348002558 MPN+ (JAMM) motif; other site 357348002559 Zinc-binding site [ion binding]; other site 357348002560 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 357348002561 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 357348002562 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 357348002563 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 357348002564 Transposase domain (DUF772); Region: DUF772; pfam05598 357348002565 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 357348002566 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 357348002567 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 357348002568 TM-ABC transporter signature motif; other site 357348002569 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 357348002570 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 357348002571 TM-ABC transporter signature motif; other site 357348002572 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 357348002573 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 357348002574 Walker A/P-loop; other site 357348002575 ATP binding site [chemical binding]; other site 357348002576 Q-loop/lid; other site 357348002577 ABC transporter signature motif; other site 357348002578 Walker B; other site 357348002579 D-loop; other site 357348002580 H-loop/switch region; other site 357348002581 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 357348002582 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 357348002583 Walker A/P-loop; other site 357348002584 ATP binding site [chemical binding]; other site 357348002585 Q-loop/lid; other site 357348002586 ABC transporter signature motif; other site 357348002587 Walker B; other site 357348002588 D-loop; other site 357348002589 H-loop/switch region; other site 357348002590 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 357348002591 putative acetyltransferase; Provisional; Region: PRK03624 357348002592 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 357348002593 acetylornithine transaminase protein; Provisional; Region: argD; PRK03715 357348002594 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 357348002595 inhibitor-cofactor binding pocket; inhibition site 357348002596 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348002597 catalytic residue [active] 357348002598 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 357348002599 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 357348002600 catalytic loop [active] 357348002601 iron binding site [ion binding]; other site 357348002602 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 357348002603 FAD binding pocket [chemical binding]; other site 357348002604 FAD binding motif [chemical binding]; other site 357348002605 phosphate binding motif [ion binding]; other site 357348002606 beta-alpha-beta structure motif; other site 357348002607 NAD binding pocket [chemical binding]; other site 357348002608 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 357348002609 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357348002610 NAD(P) binding site [chemical binding]; other site 357348002611 active site 357348002612 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 357348002613 RNA binding surface [nucleotide binding]; other site 357348002614 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 357348002615 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 357348002616 active site 357348002617 uracil binding [chemical binding]; other site 357348002618 CopC domain; Region: CopC; pfam04234 357348002619 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357348002620 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348002621 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 357348002622 dimerization interface [polypeptide binding]; other site 357348002623 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357348002624 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348002625 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 357348002626 dimerization interface [polypeptide binding]; other site 357348002627 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 357348002628 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 357348002629 MOSC domain; Region: MOSC; pfam03473 357348002630 3-alpha domain; Region: 3-alpha; pfam03475 357348002631 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 357348002632 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 357348002633 inhibitor site; inhibition site 357348002634 active site 357348002635 dimer interface [polypeptide binding]; other site 357348002636 catalytic residue [active] 357348002637 class II aldolase/adducin domain protein; Provisional; Region: PRK07090 357348002638 intersubunit interface [polypeptide binding]; other site 357348002639 active site 357348002640 Zn2+ binding site [ion binding]; other site 357348002641 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 357348002642 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 357348002643 non-specific DNA binding site [nucleotide binding]; other site 357348002644 salt bridge; other site 357348002645 sequence-specific DNA binding site [nucleotide binding]; other site 357348002646 Cupin domain; Region: Cupin_2; pfam07883 357348002647 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12684 357348002648 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348002649 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 357348002650 substrate binding site [chemical binding]; other site 357348002651 dimerization interface [polypeptide binding]; other site 357348002652 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 357348002653 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 357348002654 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 357348002655 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 357348002656 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 357348002657 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 357348002658 Active Sites [active] 357348002659 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 357348002660 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 357348002661 Active Sites [active] 357348002662 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 357348002663 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 357348002664 CysD dimerization site [polypeptide binding]; other site 357348002665 G1 box; other site 357348002666 putative GEF interaction site [polypeptide binding]; other site 357348002667 GTP/Mg2+ binding site [chemical binding]; other site 357348002668 Switch I region; other site 357348002669 G2 box; other site 357348002670 G3 box; other site 357348002671 Switch II region; other site 357348002672 G4 box; other site 357348002673 G5 box; other site 357348002674 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 357348002675 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 357348002676 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 357348002677 active site 357348002678 SAM binding site [chemical binding]; other site 357348002679 homodimer interface [polypeptide binding]; other site 357348002680 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 357348002681 putative active site [active] 357348002682 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 357348002683 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 357348002684 Predicted permeases [General function prediction only]; Region: COG0795 357348002685 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 357348002686 multifunctional aminopeptidase A; Provisional; Region: PRK00913 357348002687 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 357348002688 interface (dimer of trimers) [polypeptide binding]; other site 357348002689 Substrate-binding/catalytic site; other site 357348002690 Zn-binding sites [ion binding]; other site 357348002691 DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364 357348002692 Protein of unknown function (DUF2486); Region: DUF2486; pfam10667 357348002693 Cytochrome c; Region: Cytochrom_C; cl11414 357348002694 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 357348002695 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 357348002696 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348002697 The C-terminal substrate binding domain of LysR-type transcriptional regulator, IlvR, involved in the biosynthesis of isoleucine, leucine and valine; contains type 2 periplasmic binding fold; Region: PBP2_IlvR; cd08453 357348002698 putative dimerization interface [polypeptide binding]; other site 357348002699 putative substrate binding pocket [chemical binding]; other site 357348002700 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 357348002701 Protein of unknown function (DUF541); Region: SIMPL; cl01077 357348002702 Uncharacterized conserved protein [Function unknown]; Region: COG2947 357348002703 Cell division protein ZapA; Region: ZapA; pfam05164 357348002704 UV radiation resistance protein and autophagy-related subunit 14; Region: Atg14; pfam10186 357348002705 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 357348002706 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 357348002707 N-terminal plug; other site 357348002708 ligand-binding site [chemical binding]; other site 357348002709 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 357348002710 ABC-ATPase subunit interface; other site 357348002711 dimer interface [polypeptide binding]; other site 357348002712 putative PBP binding regions; other site 357348002713 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 357348002714 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 357348002715 Walker A/P-loop; other site 357348002716 ATP binding site [chemical binding]; other site 357348002717 Q-loop/lid; other site 357348002718 ABC transporter signature motif; other site 357348002719 Walker B; other site 357348002720 D-loop; other site 357348002721 H-loop/switch region; other site 357348002722 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 357348002723 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 357348002724 putative dimer interface [polypeptide binding]; other site 357348002725 active site pocket [active] 357348002726 putative cataytic base [active] 357348002727 cobalamin synthase; Reviewed; Region: cobS; PRK00235 357348002728 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 357348002729 catalytic core [active] 357348002730 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 357348002731 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 357348002732 cobalamin binding residues [chemical binding]; other site 357348002733 putative BtuC binding residues; other site 357348002734 dimer interface [polypeptide binding]; other site 357348002735 putative threonine-phosphate decarboxylase; Provisional; Region: PRK06959 357348002736 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 357348002737 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 357348002738 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 357348002739 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 357348002740 homotrimer interface [polypeptide binding]; other site 357348002741 Walker A motif; other site 357348002742 GTP binding site [chemical binding]; other site 357348002743 Walker B motif; other site 357348002744 cobyric acid synthase; Provisional; Region: PRK00784 357348002745 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 357348002746 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 357348002747 catalytic triad [active] 357348002748 DoxX; Region: DoxX; pfam07681 357348002749 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 357348002750 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 357348002751 P-loop; other site 357348002752 Magnesium ion binding site [ion binding]; other site 357348002753 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 357348002754 tetramerization interface [polypeptide binding]; other site 357348002755 active site 357348002756 pantoate--beta-alanine ligase; Region: panC; TIGR00018 357348002757 Pantoate-beta-alanine ligase; Region: PanC; cd00560 357348002758 active site 357348002759 ATP-binding site [chemical binding]; other site 357348002760 pantoate-binding site; other site 357348002761 HXXH motif; other site 357348002762 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 357348002763 Protein of unknown function (DUF3460); Region: DUF3460; pfam11943 357348002764 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 357348002765 Surface antigen; Region: Bac_surface_Ag; pfam01103 357348002766 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 357348002767 Family of unknown function (DUF490); Region: DUF490; pfam04357 357348002768 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 357348002769 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357348002770 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 357348002771 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 357348002772 active site 357348002773 HIGH motif; other site 357348002774 KMSKS motif; other site 357348002775 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 357348002776 tRNA binding surface [nucleotide binding]; other site 357348002777 anticodon binding site; other site 357348002778 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 357348002779 dimer interface [polypeptide binding]; other site 357348002780 putative tRNA-binding site [nucleotide binding]; other site 357348002781 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 357348002782 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 357348002783 ligand binding site [chemical binding]; other site 357348002784 Domain of unknown function DUF59; Region: DUF59; pfam01883 357348002785 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 357348002786 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 357348002787 Copper/zinc superoxide dismutase (SODC); Region: Sod_Cu; pfam00080 357348002788 E-class dimer interface [polypeptide binding]; other site 357348002789 P-class dimer interface [polypeptide binding]; other site 357348002790 active site 357348002791 Cu2+ binding site [ion binding]; other site 357348002792 Zn2+ binding site [ion binding]; other site 357348002793 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 357348002794 trimer interface [polypeptide binding]; other site 357348002795 active site 357348002796 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 357348002797 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 357348002798 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 357348002799 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 357348002800 catalytic residue [active] 357348002801 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 357348002802 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 357348002803 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 357348002804 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 357348002805 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 357348002806 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 357348002807 motif II; other site 357348002808 argininosuccinate lyase; Provisional; Region: PRK00855 357348002809 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 357348002810 active sites [active] 357348002811 tetramer interface [polypeptide binding]; other site 357348002812 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 357348002813 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 357348002814 PapC C-terminal domain; Region: PapC_C; pfam13953 357348002815 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 357348002816 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 357348002817 Uncharacterized secreted protein [Function unknown]; Region: COG5430 357348002818 Spore Coat Protein U domain; Region: SCPU; pfam05229 357348002819 Spore Coat Protein U domain; Region: SCPU; pfam05229 357348002820 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 357348002821 sequence-specific DNA binding site [nucleotide binding]; other site 357348002822 salt bridge; other site 357348002823 Methyltransferase domain; Region: Methyltransf_31; pfam13847 357348002824 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357348002825 S-adenosylmethionine binding site [chemical binding]; other site 357348002826 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 357348002827 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 357348002828 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 357348002829 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 357348002830 domain interfaces; other site 357348002831 active site 357348002832 bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase; Reviewed; Region: PRK06975 357348002833 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 357348002834 active site 357348002835 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 357348002836 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 357348002837 HemY protein N-terminus; Region: HemY_N; pfam07219 357348002838 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 357348002839 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348002840 putative substrate translocation pore; other site 357348002841 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357348002842 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 357348002843 NAD(P) binding site [chemical binding]; other site 357348002844 active site 357348002845 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 357348002846 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 357348002847 NAD(P) binding site [chemical binding]; other site 357348002848 catalytic residues [active] 357348002849 catalytic residues [active] 357348002850 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 357348002851 dimer interface [polypeptide binding]; other site 357348002852 substrate binding site [chemical binding]; other site 357348002853 metal binding sites [ion binding]; metal-binding site 357348002854 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 357348002855 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 357348002856 Protein of unknown function, DUF482; Region: DUF482; pfam04339 357348002857 NAD synthetase; Provisional; Region: PRK13981 357348002858 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 357348002859 multimer interface [polypeptide binding]; other site 357348002860 active site 357348002861 catalytic triad [active] 357348002862 protein interface 1 [polypeptide binding]; other site 357348002863 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 357348002864 homodimer interface [polypeptide binding]; other site 357348002865 NAD binding pocket [chemical binding]; other site 357348002866 ATP binding pocket [chemical binding]; other site 357348002867 Mg binding site [ion binding]; other site 357348002868 active-site loop [active] 357348002869 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 357348002870 Nitrogen regulatory protein P-II; Region: P-II; smart00938 357348002871 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 357348002872 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 357348002873 trimer interface [polypeptide binding]; other site 357348002874 eyelet of channel; other site 357348002875 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 357348002876 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 357348002877 Walker A/P-loop; other site 357348002878 ATP binding site [chemical binding]; other site 357348002879 Q-loop/lid; other site 357348002880 ABC transporter signature motif; other site 357348002881 Walker B; other site 357348002882 D-loop; other site 357348002883 H-loop/switch region; other site 357348002884 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 357348002885 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348002886 dimer interface [polypeptide binding]; other site 357348002887 conserved gate region; other site 357348002888 putative PBP binding loops; other site 357348002889 ABC-ATPase subunit interface; other site 357348002890 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 357348002891 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348002892 dimer interface [polypeptide binding]; other site 357348002893 conserved gate region; other site 357348002894 putative PBP binding loops; other site 357348002895 ABC-ATPase subunit interface; other site 357348002896 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 357348002897 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 357348002898 substrate binding pocket [chemical binding]; other site 357348002899 membrane-bound complex binding site; other site 357348002900 hinge residues; other site 357348002901 Pirin-related protein [General function prediction only]; Region: COG1741 357348002902 Pirin; Region: Pirin; pfam02678 357348002903 osmolarity response regulator; Provisional; Region: ompR; PRK09468 357348002904 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348002905 active site 357348002906 phosphorylation site [posttranslational modification] 357348002907 intermolecular recognition site; other site 357348002908 dimerization interface [polypeptide binding]; other site 357348002909 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357348002910 DNA binding site [nucleotide binding] 357348002911 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 357348002912 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357348002913 dimer interface [polypeptide binding]; other site 357348002914 phosphorylation site [posttranslational modification] 357348002915 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357348002916 ATP binding site [chemical binding]; other site 357348002917 Mg2+ binding site [ion binding]; other site 357348002918 G-X-G motif; other site 357348002919 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 357348002920 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348002921 dimer interface [polypeptide binding]; other site 357348002922 conserved gate region; other site 357348002923 putative PBP binding loops; other site 357348002924 ABC-ATPase subunit interface; other site 357348002925 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348002926 dimer interface [polypeptide binding]; other site 357348002927 conserved gate region; other site 357348002928 putative PBP binding loops; other site 357348002929 ABC-ATPase subunit interface; other site 357348002930 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 357348002931 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 357348002932 Walker A/P-loop; other site 357348002933 ATP binding site [chemical binding]; other site 357348002934 Q-loop/lid; other site 357348002935 ABC transporter signature motif; other site 357348002936 Walker B; other site 357348002937 D-loop; other site 357348002938 H-loop/switch region; other site 357348002939 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 357348002940 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 357348002941 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 357348002942 active site 357348002943 homotetramer interface [polypeptide binding]; other site 357348002944 Predicted ATPase [General function prediction only]; Region: COG3911 357348002945 AAA domain; Region: AAA_28; pfam13521 357348002946 Transposase domain (DUF772); Region: DUF772; pfam05598 357348002947 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 357348002948 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348002949 Major Facilitator Superfamily; Region: MFS_1; pfam07690 357348002950 putative substrate translocation pore; other site 357348002951 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348002952 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 357348002953 substrate binding site [chemical binding]; other site 357348002954 ecotin; Provisional; Region: PRK03719 357348002955 secondary substrate binding site; other site 357348002956 primary substrate binding site; other site 357348002957 inhibition loop; other site 357348002958 dimerization interface [polypeptide binding]; other site 357348002959 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 357348002960 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 357348002961 Inhibitor of vertebrate lysozyme (Ivy); Region: Ivy; pfam08816 357348002962 haemagglutination activity domain; Region: Haemagg_act; pfam05860 357348002963 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 357348002964 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 357348002965 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 357348002966 The BURPS668_1122 family of deaminases; Region: Toxin-deaminase; pfam14424 357348002967 Immunity protein Imm2; Region: Imm2; pfam14426 357348002968 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 357348002969 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 357348002970 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 357348002971 Integrase core domain; Region: rve_3; cl15866 357348002972 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 357348002973 rRNA binding site [nucleotide binding]; other site 357348002974 predicted 30S ribosome binding site; other site 357348002975 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 357348002976 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 357348002977 Predicted membrane protein (DUF2306); Region: DUF2306; cl02232 357348002978 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 357348002979 Rubredoxin; Region: Rubredoxin; pfam00301 357348002980 iron binding site [ion binding]; other site 357348002981 Domain of unknown function (DUF4399); Region: DUF4399; pfam14347 357348002982 ABC transporter ATPase component; Reviewed; Region: PRK11147 357348002983 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357348002984 Walker A/P-loop; other site 357348002985 ATP binding site [chemical binding]; other site 357348002986 Q-loop/lid; other site 357348002987 ABC transporter signature motif; other site 357348002988 Walker B; other site 357348002989 D-loop; other site 357348002990 H-loop/switch region; other site 357348002991 ABC transporter; Region: ABC_tran_2; pfam12848 357348002992 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 357348002993 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 357348002994 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357348002995 ATP binding site [chemical binding]; other site 357348002996 Mg2+ binding site [ion binding]; other site 357348002997 G-X-G motif; other site 357348002998 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 357348002999 anchoring element; other site 357348003000 dimer interface [polypeptide binding]; other site 357348003001 ATP binding site [chemical binding]; other site 357348003002 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 357348003003 active site 357348003004 metal binding site [ion binding]; metal-binding site 357348003005 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 357348003006 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 357348003007 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 357348003008 CAP-like domain; other site 357348003009 active site 357348003010 primary dimer interface [polypeptide binding]; other site 357348003011 Predicted integral membrane protein [Function unknown]; Region: COG5615 357348003012 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348003013 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357348003014 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 357348003015 dimerization interface [polypeptide binding]; other site 357348003016 Predicted membrane protein [Function unknown]; Region: COG4125 357348003017 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 357348003018 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 357348003019 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357348003020 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348003021 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 357348003022 dimerization interface [polypeptide binding]; other site 357348003023 metabolite-proton symporter; Region: 2A0106; TIGR00883 357348003024 allantoate amidohydrolase; Reviewed; Region: PRK12893 357348003025 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 357348003026 active site 357348003027 metal binding site [ion binding]; metal-binding site 357348003028 dimer interface [polypeptide binding]; other site 357348003029 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 357348003030 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 357348003031 active site 357348003032 Zn binding site [ion binding]; other site 357348003033 Chromate transporter; Region: Chromate_transp; pfam02417 357348003034 Chromate transporter; Region: Chromate_transp; pfam02417 357348003035 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 357348003036 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 357348003037 metal binding site [ion binding]; metal-binding site 357348003038 active site 357348003039 I-site; other site 357348003040 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 357348003041 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 357348003042 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 357348003043 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 357348003044 homotrimer interaction site [polypeptide binding]; other site 357348003045 putative active site [active] 357348003046 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 357348003047 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 357348003048 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348003049 homodimer interface [polypeptide binding]; other site 357348003050 catalytic residue [active] 357348003051 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 357348003052 EamA-like transporter family; Region: EamA; pfam00892 357348003053 EamA-like transporter family; Region: EamA; pfam00892 357348003054 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 357348003055 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 357348003056 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 357348003057 DNA-binding site [nucleotide binding]; DNA binding site 357348003058 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 357348003059 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348003060 homodimer interface [polypeptide binding]; other site 357348003061 catalytic residue [active] 357348003062 heat shock protein 90; Provisional; Region: PRK05218 357348003063 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357348003064 ATP binding site [chemical binding]; other site 357348003065 Mg2+ binding site [ion binding]; other site 357348003066 G-X-G motif; other site 357348003067 Chorismate lyase; Region: Chor_lyase; cl01230 357348003068 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 357348003069 putative active site [active] 357348003070 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 357348003071 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 357348003072 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 357348003073 Na binding site [ion binding]; other site 357348003074 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 357348003075 dimer interface [polypeptide binding]; other site 357348003076 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 357348003077 transaldolase-like protein; Provisional; Region: PTZ00411 357348003078 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 357348003079 active site 357348003080 dimer interface [polypeptide binding]; other site 357348003081 catalytic residue [active] 357348003082 Benzoate membrane transport protein; Region: BenE; pfam03594 357348003083 benzoate transporter; Region: benE; TIGR00843 357348003084 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 357348003085 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 357348003086 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357348003087 Walker A motif; other site 357348003088 ATP binding site [chemical binding]; other site 357348003089 Walker B motif; other site 357348003090 arginine finger; other site 357348003091 Cytochrome c553 [Energy production and conversion]; Region: COG2863 357348003092 Cytochrome c; Region: Cytochrom_C; cl11414 357348003093 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 357348003094 EamA-like transporter family; Region: EamA; pfam00892 357348003095 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 357348003096 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 357348003097 minor groove reading motif; other site 357348003098 helix-hairpin-helix signature motif; other site 357348003099 substrate binding pocket [chemical binding]; other site 357348003100 active site 357348003101 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 357348003102 ferredoxin; Provisional; Region: PRK06991 357348003103 Putative Fe-S cluster; Region: FeS; pfam04060 357348003104 4Fe-4S binding domain; Region: Fer4; pfam00037 357348003105 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 357348003106 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 357348003107 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 357348003108 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 357348003109 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 357348003110 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 357348003111 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 357348003112 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 357348003113 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 357348003114 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 357348003115 META domain; Region: META; pfam03724 357348003116 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 357348003117 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357348003118 ATP-grasp domain; Region: ATP-grasp; pfam02222 357348003119 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 357348003120 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 357348003121 DEAD-like helicases superfamily; Region: DEXDc; smart00487 357348003122 ATP binding site [chemical binding]; other site 357348003123 Mg++ binding site [ion binding]; other site 357348003124 motif III; other site 357348003125 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 357348003126 nucleotide binding region [chemical binding]; other site 357348003127 ATP-binding site [chemical binding]; other site 357348003128 glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838 357348003129 active site 357348003130 HIGH motif; other site 357348003131 nucleotide binding site [chemical binding]; other site 357348003132 KMSKS motif; other site 357348003133 rhodanese superfamily protein; Provisional; Region: PRK05320 357348003134 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 357348003135 active site residue [active] 357348003136 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 357348003137 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 357348003138 putative active site [active] 357348003139 putative PHP Thumb interface [polypeptide binding]; other site 357348003140 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 357348003141 generic binding surface II; other site 357348003142 generic binding surface I; other site 357348003143 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 357348003144 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 357348003145 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 357348003146 Walker A/P-loop; other site 357348003147 ATP binding site [chemical binding]; other site 357348003148 Q-loop/lid; other site 357348003149 ABC transporter signature motif; other site 357348003150 Walker B; other site 357348003151 D-loop; other site 357348003152 H-loop/switch region; other site 357348003153 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 357348003154 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 357348003155 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 357348003156 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 357348003157 putative active site [active] 357348003158 O-Antigen ligase; Region: Wzy_C; cl04850 357348003159 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357348003160 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 357348003161 putative ADP-binding pocket [chemical binding]; other site 357348003162 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 357348003163 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 357348003164 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 357348003165 putative active site [active] 357348003166 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 357348003167 putative metal binding site; other site 357348003168 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 357348003169 Major Facilitator Superfamily; Region: MFS_1; pfam07690 357348003170 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 357348003171 Uncharacterized conserved protein [Function unknown]; Region: COG2128 357348003172 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 357348003173 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 357348003174 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 357348003175 DNA binding residues [nucleotide binding] 357348003176 Lipocalin-like domain; Region: Lipocalin_5; pfam13924 357348003177 phospholipase C accessory protein PlcR; Region: plc_access_R; TIGR03398 357348003178 Pectinacetylesterase; Region: PAE; pfam03283 357348003179 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 357348003180 ribonuclease G; Provisional; Region: PRK11712 357348003181 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 357348003182 homodimer interface [polypeptide binding]; other site 357348003183 oligonucleotide binding site [chemical binding]; other site 357348003184 Maf-like protein; Region: Maf; pfam02545 357348003185 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 357348003186 active site 357348003187 dimer interface [polypeptide binding]; other site 357348003188 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 357348003189 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 357348003190 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 357348003191 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 357348003192 active site 357348003193 (T/H)XGH motif; other site 357348003194 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 357348003195 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 357348003196 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 357348003197 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 357348003198 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 357348003199 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 357348003200 hypothetical protein; Validated; Region: PRK00110 357348003201 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 357348003202 active site 357348003203 short chain dehydrogenase; Provisional; Region: PRK08339 357348003204 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 357348003205 putative NAD(P) binding site [chemical binding]; other site 357348003206 putative active site [active] 357348003207 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 357348003208 active site 357348003209 dimer interfaces [polypeptide binding]; other site 357348003210 catalytic residues [active] 357348003211 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 357348003212 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 357348003213 NADP binding site [chemical binding]; other site 357348003214 dimer interface [polypeptide binding]; other site 357348003215 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 357348003216 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 357348003217 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 357348003218 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 357348003219 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 357348003220 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 357348003221 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 357348003222 Ligand Binding Site [chemical binding]; other site 357348003223 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 357348003224 GAF domain; Region: GAF_3; pfam13492 357348003225 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357348003226 dimer interface [polypeptide binding]; other site 357348003227 phosphorylation site [posttranslational modification] 357348003228 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357348003229 ATP binding site [chemical binding]; other site 357348003230 Mg2+ binding site [ion binding]; other site 357348003231 G-X-G motif; other site 357348003232 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 357348003233 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348003234 active site 357348003235 phosphorylation site [posttranslational modification] 357348003236 intermolecular recognition site; other site 357348003237 dimerization interface [polypeptide binding]; other site 357348003238 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357348003239 DNA binding site [nucleotide binding] 357348003240 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 357348003241 Domain of unknown function (DUF333); Region: DUF333; pfam03891 357348003242 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 357348003243 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 357348003244 FtsX-like permease family; Region: FtsX; pfam02687 357348003245 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 357348003246 apolar tunnel; other site 357348003247 heme binding site [chemical binding]; other site 357348003248 dimerization interface [polypeptide binding]; other site 357348003249 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 357348003250 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 357348003251 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 357348003252 amidase; Provisional; Region: PRK07042 357348003253 Amidase; Region: Amidase; cl11426 357348003254 metabolite-proton symporter; Region: 2A0106; TIGR00883 357348003255 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 357348003256 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 357348003257 glucose-1-dehydrogenase; Provisional; Region: PRK06947 357348003258 classical (c) SDRs; Region: SDR_c; cd05233 357348003259 NAD(P) binding site [chemical binding]; other site 357348003260 active site 357348003261 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 357348003262 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 357348003263 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 357348003264 Bacterial transcriptional repressor; Region: TetR; pfam13972 357348003265 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 357348003266 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357348003267 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 357348003268 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 357348003269 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 357348003270 putative active site [active] 357348003271 putative metal binding site [ion binding]; other site 357348003272 RDD family; Region: RDD; pfam06271 357348003273 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 357348003274 Protein of unknown function (DUF3619); Region: DUF3619; pfam12279 357348003275 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 357348003276 RNA polymerase factor sigma-70; Validated; Region: PRK09047 357348003277 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 357348003278 DNA binding residues [nucleotide binding] 357348003279 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06965 357348003280 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 357348003281 PYR/PP interface [polypeptide binding]; other site 357348003282 dimer interface [polypeptide binding]; other site 357348003283 TPP binding site [chemical binding]; other site 357348003284 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 357348003285 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 357348003286 TPP-binding site [chemical binding]; other site 357348003287 dimer interface [polypeptide binding]; other site 357348003288 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 357348003289 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 357348003290 putative valine binding site [chemical binding]; other site 357348003291 dimer interface [polypeptide binding]; other site 357348003292 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 357348003293 ketol-acid reductoisomerase; Provisional; Region: PRK05479 357348003294 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 357348003295 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 357348003296 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 357348003297 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 357348003298 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 357348003299 2-isopropylmalate synthase; Validated; Region: PRK00915 357348003300 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 357348003301 active site 357348003302 catalytic residues [active] 357348003303 metal binding site [ion binding]; metal-binding site 357348003304 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 357348003305 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 357348003306 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 357348003307 Sulfate transporter family; Region: Sulfate_transp; pfam00916 357348003308 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 357348003309 active site clefts [active] 357348003310 zinc binding site [ion binding]; other site 357348003311 dimer interface [polypeptide binding]; other site 357348003312 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 357348003313 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329 357348003314 putative ligand binding site [chemical binding]; other site 357348003315 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 357348003316 16S/18S rRNA binding site [nucleotide binding]; other site 357348003317 S13e-L30e interaction site [polypeptide binding]; other site 357348003318 25S rRNA binding site [nucleotide binding]; other site 357348003319 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 357348003320 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 357348003321 RNase E interface [polypeptide binding]; other site 357348003322 trimer interface [polypeptide binding]; other site 357348003323 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 357348003324 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 357348003325 RNase E interface [polypeptide binding]; other site 357348003326 trimer interface [polypeptide binding]; other site 357348003327 active site 357348003328 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 357348003329 putative nucleic acid binding region [nucleotide binding]; other site 357348003330 G-X-X-G motif; other site 357348003331 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 357348003332 RNA binding site [nucleotide binding]; other site 357348003333 domain interface; other site 357348003334 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 357348003335 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 357348003336 NAD(P) binding site [chemical binding]; other site 357348003337 triosephosphate isomerase; Provisional; Region: PRK14567 357348003338 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 357348003339 substrate binding site [chemical binding]; other site 357348003340 dimer interface [polypeptide binding]; other site 357348003341 catalytic triad [active] 357348003342 Preprotein translocase SecG subunit; Region: SecG; pfam03840 357348003343 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 357348003344 NADH dehydrogenase subunit B; Validated; Region: PRK06411 357348003345 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 357348003346 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 357348003347 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 357348003348 NADH dehydrogenase subunit D; Validated; Region: PRK06075 357348003349 NADH dehydrogenase subunit E; Validated; Region: PRK07539 357348003350 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 357348003351 putative dimer interface [polypeptide binding]; other site 357348003352 [2Fe-2S] cluster binding site [ion binding]; other site 357348003353 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 357348003354 SLBB domain; Region: SLBB; pfam10531 357348003355 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 357348003356 NADH dehydrogenase subunit G; Validated; Region: PRK09129 357348003357 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 357348003358 catalytic loop [active] 357348003359 iron binding site [ion binding]; other site 357348003360 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 357348003361 MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772 357348003362 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 357348003363 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 357348003364 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 357348003365 4Fe-4S binding domain; Region: Fer4; cl02805 357348003366 4Fe-4S binding domain; Region: Fer4; pfam00037 357348003367 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 357348003368 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 357348003369 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 357348003370 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 357348003371 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 357348003372 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 357348003373 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 357348003374 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 357348003375 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 357348003376 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 357348003377 Protein of unknown function (DUF2818); Region: DUF2818; pfam10993 357348003378 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 357348003379 dimer interface [polypeptide binding]; other site 357348003380 ADP-ribose binding site [chemical binding]; other site 357348003381 active site 357348003382 nudix motif; other site 357348003383 metal binding site [ion binding]; metal-binding site 357348003384 Protein of unknown function (DUF1178); Region: DUF1178; pfam06676 357348003385 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 357348003386 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 357348003387 FAD binding site [chemical binding]; other site 357348003388 substrate binding site [chemical binding]; other site 357348003389 catalytic base [active] 357348003390 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 357348003391 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 357348003392 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 357348003393 active site 357348003394 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 357348003395 putative active site [active] 357348003396 putative catalytic site [active] 357348003397 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 357348003398 putative active site [active] 357348003399 putative catalytic site [active] 357348003400 Right handed beta helix region; Region: Beta_helix; pfam13229 357348003401 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 357348003402 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 357348003403 FAD binding site [chemical binding]; other site 357348003404 substrate binding site [chemical binding]; other site 357348003405 catalytic base [active] 357348003406 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 357348003407 putative active site [active] 357348003408 putative substrate binding site [chemical binding]; other site 357348003409 ATP binding site [chemical binding]; other site 357348003410 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 357348003411 catalytic core [active] 357348003412 enoyl-CoA hydratase; Provisional; Region: PRK07511 357348003413 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 357348003414 substrate binding site [chemical binding]; other site 357348003415 oxyanion hole (OAH) forming residues; other site 357348003416 trimer interface [polypeptide binding]; other site 357348003417 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 357348003418 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 357348003419 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 357348003420 C-terminal domain interface [polypeptide binding]; other site 357348003421 GSH binding site (G-site) [chemical binding]; other site 357348003422 dimer interface [polypeptide binding]; other site 357348003423 C-terminal, alpha helical domain of an unknown subfamily 9 of Glutathione S-transferases; Region: GST_C_9; cd10424 357348003424 putative N-terminal domain interface [polypeptide binding]; other site 357348003425 putative dimer interface [polypeptide binding]; other site 357348003426 putative substrate binding pocket (H-site) [chemical binding]; other site 357348003427 methionine aminotransferase; Validated; Region: PRK09082 357348003428 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 357348003429 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348003430 homodimer interface [polypeptide binding]; other site 357348003431 catalytic residue [active] 357348003432 PIN domain; Region: PIN_3; pfam13470 357348003433 PIN domain; Region: PIN_3; cl17397 357348003434 hypothetical protein; Validated; Region: PRK02101 357348003435 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 357348003436 Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases; uncharacterized bacterial subgroup; Region: M14_Nna1_like_1; cd06234 357348003437 putative active site [active] 357348003438 Zn binding site [ion binding]; other site 357348003439 Predicted membrane protein [Function unknown]; Region: COG3235 357348003440 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 357348003441 Flagellar regulatory protein FleQ; Region: FleQ; pfam06490 357348003442 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 357348003443 DNA binding residues [nucleotide binding] 357348003444 dimerization interface [polypeptide binding]; other site 357348003445 Protein of unknown function (DUF2863); Region: DUF2863; pfam11062 357348003446 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 357348003447 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 357348003448 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 357348003449 active site 357348003450 Fatty acid desaturase; Region: FA_desaturase; pfam00487 357348003451 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 357348003452 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357348003453 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357348003454 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 357348003455 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 357348003456 ligand binding site [chemical binding]; other site 357348003457 NAD binding site [chemical binding]; other site 357348003458 tetramer interface [polypeptide binding]; other site 357348003459 catalytic site [active] 357348003460 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 357348003461 L-serine binding site [chemical binding]; other site 357348003462 ACT domain interface; other site 357348003463 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 357348003464 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 357348003465 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 357348003466 substrate binding pocket [chemical binding]; other site 357348003467 membrane-bound complex binding site; other site 357348003468 hinge residues; other site 357348003469 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 357348003470 Histidine kinase; Region: HisKA_3; pfam07730 357348003471 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357348003472 ATP binding site [chemical binding]; other site 357348003473 Mg2+ binding site [ion binding]; other site 357348003474 G-X-G motif; other site 357348003475 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 357348003476 catalytic motif [active] 357348003477 Catalytic residue [active] 357348003478 Aspartyl protease; Region: Asp_protease_2; pfam13650 357348003479 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 357348003480 Cytochrome c; Region: Cytochrom_C; cl11414 357348003481 Cytochrome c; Region: Cytochrom_C; cl11414 357348003482 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 357348003483 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 357348003484 Cytochrome c; Region: Cytochrom_C; pfam00034 357348003485 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 357348003486 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 357348003487 ba3-like heme-copper oxidase subunit I. The ba3 family of heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and some archaea which catalyze the reduction of O2 and simultaneously pump protons across the...; Region: ba3-like_Oxidase_I; cd01660 357348003488 Putative D-pathway homolog; other site 357348003489 Low-spin heme binding site [chemical binding]; other site 357348003490 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 357348003491 Subunit I/II interface [polypeptide binding]; other site 357348003492 Putative Q-pathway; other site 357348003493 Putative alternate electron transfer pathway; other site 357348003494 Putative water exit pathway; other site 357348003495 Binuclear center (active site) [active] 357348003496 Putative K-pathway homolog; other site 357348003497 Putative proton exit pathway; other site 357348003498 Subunit I/IIa interface [polypeptide binding]; other site 357348003499 Electron transfer pathway; other site 357348003500 Cytochrome c553 [Energy production and conversion]; Region: COG2863 357348003501 Cytochrome c; Region: Cytochrom_C; cl11414 357348003502 HDOD domain; Region: HDOD; pfam08668 357348003503 PAS domain; Region: PAS_9; pfam13426 357348003504 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 357348003505 putative active site [active] 357348003506 heme pocket [chemical binding]; other site 357348003507 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 357348003508 metal binding site [ion binding]; metal-binding site 357348003509 active site 357348003510 I-site; other site 357348003511 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 357348003512 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 357348003513 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 357348003514 catalytic triad [active] 357348003515 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 357348003516 NADH(P)-binding; Region: NAD_binding_10; pfam13460 357348003517 NAD(P) binding site [chemical binding]; other site 357348003518 putative active site [active] 357348003519 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 357348003520 Protein export membrane protein; Region: SecD_SecF; cl14618 357348003521 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 357348003522 Protein export membrane protein; Region: SecD_SecF; cl14618 357348003523 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 357348003524 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 357348003525 HlyD family secretion protein; Region: HlyD_3; pfam13437 357348003526 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 357348003527 Transcriptional regulator [Transcription]; Region: IclR; COG1414 357348003528 Bacterial transcriptional regulator; Region: IclR; pfam01614 357348003529 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 357348003530 Predicted transcriptional regulator [Transcription]; Region: COG1959 357348003531 Transcriptional regulator; Region: Rrf2; pfam02082 357348003532 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 357348003533 NADH(P)-binding; Region: NAD_binding_10; pfam13460 357348003534 NAD binding site [chemical binding]; other site 357348003535 putative active site [active] 357348003536 substrate binding site [chemical binding]; other site 357348003537 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 357348003538 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 357348003539 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 357348003540 putative DNA binding site [nucleotide binding]; other site 357348003541 putative Zn2+ binding site [ion binding]; other site 357348003542 AsnC family; Region: AsnC_trans_reg; pfam01037 357348003543 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 357348003544 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 357348003545 Walker A/P-loop; other site 357348003546 ATP binding site [chemical binding]; other site 357348003547 Q-loop/lid; other site 357348003548 ABC transporter signature motif; other site 357348003549 Walker B; other site 357348003550 D-loop; other site 357348003551 H-loop/switch region; other site 357348003552 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 357348003553 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348003554 ABC-ATPase subunit interface; other site 357348003555 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348003556 ABC-ATPase subunit interface; other site 357348003557 putative PBP binding loops; other site 357348003558 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 357348003559 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 357348003560 putative proline-specific permease; Provisional; Region: proY; PRK10580 357348003561 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 357348003562 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 357348003563 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 357348003564 trimer interface [polypeptide binding]; other site 357348003565 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 357348003566 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 357348003567 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 357348003568 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 357348003569 Family description; Region: UvrD_C_2; pfam13538 357348003570 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 357348003571 AAA domain; Region: AAA_30; pfam13604 357348003572 Family description; Region: UvrD_C_2; pfam13538 357348003573 hypothetical protein; Provisional; Region: PRK09256 357348003574 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 357348003575 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 357348003576 EamA-like transporter family; Region: EamA; pfam00892 357348003577 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 357348003578 EamA-like transporter family; Region: EamA; pfam00892 357348003579 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 357348003580 ThiC-associated domain; Region: ThiC-associated; pfam13667 357348003581 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 357348003582 Protein of unknown function (DUF1223); Region: DUF1223; cl10501 357348003583 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 357348003584 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 357348003585 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 357348003586 Moco binding site; other site 357348003587 metal coordination site [ion binding]; other site 357348003588 EamA-like transporter family; Region: EamA; pfam00892 357348003589 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348003590 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 357348003591 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 357348003592 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 357348003593 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 357348003594 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 357348003595 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 357348003596 active site 357348003597 metal binding site [ion binding]; metal-binding site 357348003598 hexamer interface [polypeptide binding]; other site 357348003599 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 357348003600 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357348003601 Walker A/P-loop; other site 357348003602 ATP binding site [chemical binding]; other site 357348003603 Q-loop/lid; other site 357348003604 ABC transporter signature motif; other site 357348003605 Walker B; other site 357348003606 D-loop; other site 357348003607 H-loop/switch region; other site 357348003608 TOBE domain; Region: TOBE_2; pfam08402 357348003609 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 357348003610 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348003611 putative PBP binding loops; other site 357348003612 ABC-ATPase subunit interface; other site 357348003613 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 357348003614 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 357348003615 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 357348003616 Transcriptional regulators [Transcription]; Region: PurR; COG1609 357348003617 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 357348003618 DNA binding site [nucleotide binding] 357348003619 domain linker motif; other site 357348003620 Ligand-binding domain of putative DNA transcription repressors highly similar to that of the repressor specific for gluconate (GntR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_2; cd06282 357348003621 putative dimerization interface [polypeptide binding]; other site 357348003622 putative ligand binding site [chemical binding]; other site 357348003623 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 357348003624 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 357348003625 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 357348003626 Walker A motif; other site 357348003627 ATP binding site [chemical binding]; other site 357348003628 Protein of unknown function (DUF1376); Region: DUF1376; pfam07120 357348003629 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 357348003630 integrase; Provisional; Region: PRK09692 357348003631 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 357348003632 active site 357348003633 Int/Topo IB signature motif; other site 357348003634 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 357348003635 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 357348003636 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 357348003637 metal binding site [ion binding]; metal-binding site 357348003638 active site 357348003639 I-site; other site 357348003640 Protein of unknown function (DUF1326); Region: DUF1326; pfam07040 357348003641 Predicted metal-binding integral membrane protein [Function unknown]; Region: COG5486 357348003642 Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948 357348003643 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 357348003644 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 357348003645 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 357348003646 DNA-binding site [nucleotide binding]; DNA binding site 357348003647 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 357348003648 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348003649 homodimer interface [polypeptide binding]; other site 357348003650 catalytic residue [active] 357348003651 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 357348003652 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 357348003653 putative DNA binding site [nucleotide binding]; other site 357348003654 putative Zn2+ binding site [ion binding]; other site 357348003655 AsnC family; Region: AsnC_trans_reg; pfam01037 357348003656 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 357348003657 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 357348003658 glutaminase active site [active] 357348003659 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 357348003660 dimer interface [polypeptide binding]; other site 357348003661 active site 357348003662 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 357348003663 dimer interface [polypeptide binding]; other site 357348003664 active site 357348003665 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 357348003666 Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998 357348003667 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357348003668 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348003669 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 357348003670 putative effector binding pocket; other site 357348003671 putative dimerization interface [polypeptide binding]; other site 357348003672 short chain dehydrogenase; Provisional; Region: PRK12744 357348003673 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357348003674 NAD(P) binding site [chemical binding]; other site 357348003675 active site 357348003676 Uncharacterized protein conserved in bacteria (DUF2242); Region: DUF2242; pfam10001 357348003677 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 357348003678 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 357348003679 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 357348003680 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 357348003681 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 357348003682 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 357348003683 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 357348003684 DNA-binding site [nucleotide binding]; DNA binding site 357348003685 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 357348003686 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348003687 homodimer interface [polypeptide binding]; other site 357348003688 catalytic residue [active] 357348003689 GSCFA family; Region: GSCFA; pfam08885 357348003690 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 357348003691 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 357348003692 putative dimer interface [polypeptide binding]; other site 357348003693 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 357348003694 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 357348003695 putative dimer interface [polypeptide binding]; other site 357348003696 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 357348003697 active site 357348003698 substrate-binding site [chemical binding]; other site 357348003699 metal-binding site [ion binding] 357348003700 GTP binding site [chemical binding]; other site 357348003701 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 357348003702 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 357348003703 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 357348003704 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357348003705 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348003706 LysR substrate binding domain; Region: LysR_substrate; pfam03466 357348003707 dimerization interface [polypeptide binding]; other site 357348003708 Malonate transporter MadL subunit; Region: MadL; cl04273 357348003709 Malonate/sodium symporter MadM subunit; Region: MadM; cl04274 357348003710 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 357348003711 Coenzyme A transferase; Region: CoA_trans; cl17247 357348003712 malonate decarboxylase subunit delta; Provisional; Region: PRK02103 357348003713 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 357348003714 malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134 357348003715 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK02098 357348003716 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293; cl07913 357348003717 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 357348003718 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 357348003719 Acyl transferase domain; Region: Acyl_transf_1; cl08282 357348003720 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 357348003721 putative active site [active] 357348003722 catalytic site [active] 357348003723 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 357348003724 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 357348003725 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 357348003726 C-terminal domain interface [polypeptide binding]; other site 357348003727 GSH binding site (G-site) [chemical binding]; other site 357348003728 dimer interface [polypeptide binding]; other site 357348003729 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 357348003730 N-terminal domain interface [polypeptide binding]; other site 357348003731 proline/glycine betaine transporter; Provisional; Region: PRK10642 357348003732 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348003733 putative substrate translocation pore; other site 357348003734 hypothetical protein; Provisional; Region: PRK02237 357348003735 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 357348003736 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 357348003737 active site 357348003738 catalytic site [active] 357348003739 substrate binding site [chemical binding]; other site 357348003740 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 357348003741 RNA/DNA hybrid binding site [nucleotide binding]; other site 357348003742 active site 357348003743 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357348003744 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 357348003745 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 357348003746 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 357348003747 N-acetyl-D-glucosamine binding site [chemical binding]; other site 357348003748 catalytic residue [active] 357348003749 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 357348003750 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 357348003751 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348003752 Major Facilitator Superfamily; Region: MFS_1; pfam07690 357348003753 putative substrate translocation pore; other site 357348003754 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 357348003755 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357348003756 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357348003757 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 357348003758 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 357348003759 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 357348003760 catalytic site [active] 357348003761 subunit interface [polypeptide binding]; other site 357348003762 leucine export protein LeuE; Provisional; Region: PRK10958 357348003763 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 357348003764 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 357348003765 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 357348003766 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 357348003767 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 357348003768 ATP-grasp domain; Region: ATP-grasp_4; cl17255 357348003769 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 357348003770 IMP binding site; other site 357348003771 dimer interface [polypeptide binding]; other site 357348003772 interdomain contacts; other site 357348003773 partial ornithine binding site; other site 357348003774 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 357348003775 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 357348003776 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 357348003777 Domain of unknown function (DUF4149); Region: DUF4149; pfam13664 357348003778 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 357348003779 FtsJ-like methyltransferase; Region: FtsJ; cl17430 357348003780 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 357348003781 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 357348003782 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357348003783 Walker A motif; other site 357348003784 ATP binding site [chemical binding]; other site 357348003785 Walker B motif; other site 357348003786 arginine finger; other site 357348003787 Peptidase family M41; Region: Peptidase_M41; pfam01434 357348003788 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 357348003789 dihydropteroate synthase; Region: DHPS; TIGR01496 357348003790 substrate binding pocket [chemical binding]; other site 357348003791 dimer interface [polypeptide binding]; other site 357348003792 inhibitor binding site; inhibition site 357348003793 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 357348003794 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 357348003795 active site 357348003796 substrate binding site [chemical binding]; other site 357348003797 metal binding site [ion binding]; metal-binding site 357348003798 PBP superfamily domain; Region: PBP_like_2; cl17296 357348003799 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 357348003800 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348003801 dimer interface [polypeptide binding]; other site 357348003802 conserved gate region; other site 357348003803 putative PBP binding loops; other site 357348003804 ABC-ATPase subunit interface; other site 357348003805 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 357348003806 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348003807 dimer interface [polypeptide binding]; other site 357348003808 conserved gate region; other site 357348003809 putative PBP binding loops; other site 357348003810 ABC-ATPase subunit interface; other site 357348003811 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 357348003812 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 357348003813 Walker A/P-loop; other site 357348003814 ATP binding site [chemical binding]; other site 357348003815 Q-loop/lid; other site 357348003816 ABC transporter signature motif; other site 357348003817 Walker B; other site 357348003818 D-loop; other site 357348003819 H-loop/switch region; other site 357348003820 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 357348003821 PhoU domain; Region: PhoU; pfam01895 357348003822 PhoU domain; Region: PhoU; pfam01895 357348003823 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 357348003824 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348003825 active site 357348003826 phosphorylation site [posttranslational modification] 357348003827 intermolecular recognition site; other site 357348003828 dimerization interface [polypeptide binding]; other site 357348003829 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357348003830 DNA binding site [nucleotide binding] 357348003831 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 357348003832 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357348003833 dimer interface [polypeptide binding]; other site 357348003834 phosphorylation site [posttranslational modification] 357348003835 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357348003836 ATP binding site [chemical binding]; other site 357348003837 Mg2+ binding site [ion binding]; other site 357348003838 G-X-G motif; other site 357348003839 polyphosphate kinase; Provisional; Region: PRK05443 357348003840 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 357348003841 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 357348003842 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 357348003843 putative active site [active] 357348003844 catalytic site [active] 357348003845 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 357348003846 putative domain interface [polypeptide binding]; other site 357348003847 putative active site [active] 357348003848 catalytic site [active] 357348003849 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 357348003850 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 357348003851 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 357348003852 active site 357348003853 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 357348003854 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 357348003855 catalytic core [active] 357348003856 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 357348003857 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 357348003858 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 357348003859 Protein of unknown function (DUF2288); Region: DUF2288; pfam10052 357348003860 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 357348003861 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_3; cd05971 357348003862 active site 357348003863 acyl-activating enzyme (AAE) consensus motif; other site 357348003864 putative CoA binding site [chemical binding]; other site 357348003865 AMP binding site [chemical binding]; other site 357348003866 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 357348003867 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 357348003868 Peptidase family M23; Region: Peptidase_M23; pfam01551 357348003869 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 357348003870 active site 357348003871 catalytic residues [active] 357348003872 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 357348003873 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 357348003874 DNA binding site [nucleotide binding] 357348003875 active site 357348003876 Int/Topo IB signature motif; other site 357348003877 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 357348003878 HTH-like domain; Region: HTH_21; pfam13276 357348003879 Integrase core domain; Region: rve; pfam00665 357348003880 Integrase core domain; Region: rve_3; pfam13683 357348003881 Transposase; Region: HTH_Tnp_1; pfam01527 357348003882 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 357348003883 PAAR motif; Region: PAAR_motif; pfam05488 357348003884 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 357348003885 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 357348003886 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 357348003887 Leucine carboxyl methyltransferase; Region: LCM; cl01306 357348003888 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 357348003889 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 357348003890 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 357348003891 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348003892 homodimer interface [polypeptide binding]; other site 357348003893 catalytic residue [active] 357348003894 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 357348003895 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 357348003896 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 357348003897 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 357348003898 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 357348003899 active site 357348003900 catalytic site [active] 357348003901 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 357348003902 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 357348003903 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 357348003904 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 357348003905 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 357348003906 active site 357348003907 catalytic site [active] 357348003908 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 357348003909 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 357348003910 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 357348003911 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 357348003912 active site 357348003913 catalytic site [active] 357348003914 glycogen branching enzyme; Provisional; Region: PRK05402 357348003915 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 357348003916 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 357348003917 active site 357348003918 catalytic site [active] 357348003919 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 357348003920 trehalose synthase; Region: treS_nterm; TIGR02456 357348003921 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 357348003922 active site 357348003923 catalytic site [active] 357348003924 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 357348003925 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 357348003926 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 357348003927 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 357348003928 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 357348003929 active site 357348003930 homodimer interface [polypeptide binding]; other site 357348003931 catalytic site [active] 357348003932 acceptor binding site [chemical binding]; other site 357348003933 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 357348003934 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 357348003935 Interdomain contacts; other site 357348003936 Cytokine receptor motif; other site 357348003937 Glycoside hydrolase family 44; Region: Glyco_hydro_44; pfam12891 357348003938 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357348003939 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348003940 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 357348003941 dimerization interface [polypeptide binding]; other site 357348003942 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 357348003943 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348003944 active site 357348003945 phosphorylation site [posttranslational modification] 357348003946 intermolecular recognition site; other site 357348003947 dimerization interface [polypeptide binding]; other site 357348003948 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357348003949 DNA binding site [nucleotide binding] 357348003950 Protein of unknown function (DUF3955); Region: DUF3955; pfam13127 357348003951 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 357348003952 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 357348003953 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 357348003954 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348003955 active site 357348003956 phosphorylation site [posttranslational modification] 357348003957 intermolecular recognition site; other site 357348003958 dimerization interface [polypeptide binding]; other site 357348003959 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357348003960 DNA binding site [nucleotide binding] 357348003961 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 357348003962 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 357348003963 trimer interface [polypeptide binding]; other site 357348003964 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 357348003965 trimer interface [polypeptide binding]; other site 357348003966 YadA-like C-terminal region; Region: YadA; pfam03895 357348003967 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 357348003968 ligand binding site [chemical binding]; other site 357348003969 TPR repeat; Region: TPR_11; pfam13414 357348003970 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357348003971 binding surface 357348003972 TPR motif; other site 357348003973 ADP-heptose:LPS heptosyl transferase I; Provisional; Region: PRK10964; cl15782 357348003974 H-NS histone family; Region: Histone_HNS; pfam00816 357348003975 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 357348003976 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 357348003977 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 357348003978 Cu(I) binding site [ion binding]; other site 357348003979 Ricin-type beta-trefoil; Region: RICIN; smart00458 357348003980 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 357348003981 putative sugar binding sites [chemical binding]; other site 357348003982 Q-X-W motif; other site 357348003983 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 357348003984 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 357348003985 Galactose oxidase, central domain; Region: Kelch_3; cl02701 357348003986 Kelch motif; Region: Kelch_6; pfam13964 357348003987 C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851 357348003988 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 357348003989 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 357348003990 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 357348003991 PAAR motif; Region: PAAR_motif; pfam05488 357348003992 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 357348003993 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 357348003994 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 357348003995 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 357348003996 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 357348003997 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 357348003998 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 357348003999 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 357348004000 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 357348004001 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 357348004002 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 357348004003 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 357348004004 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 357348004005 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 357348004006 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 357348004007 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 357348004008 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 357348004009 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 357348004010 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 357348004011 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 357348004012 H-NS histone family; Region: Histone_HNS; pfam00816 357348004013 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 357348004014 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 357348004015 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 357348004016 active site 357348004017 benzoate transport; Region: 2A0115; TIGR00895 357348004018 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348004019 putative substrate translocation pore; other site 357348004020 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 357348004021 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348004022 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 357348004023 dimerization interface [polypeptide binding]; other site 357348004024 substrate binding pocket [chemical binding]; other site 357348004025 Spore Coat Protein U domain; Region: SCPU; pfam05229 357348004026 Spore Coat Protein U domain; Region: SCPU; pfam05229 357348004027 Spore Coat Protein U domain; Region: SCPU; pfam05229 357348004028 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 357348004029 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 357348004030 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 357348004031 PapC N-terminal domain; Region: PapC_N; pfam13954 357348004032 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 357348004033 PapC C-terminal domain; Region: PapC_C; pfam13953 357348004034 Spore Coat Protein U domain; Region: SCPU; pfam05229 357348004035 Spore Coat Protein U domain; Region: SCPU; pfam05229 357348004036 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357348004037 dimer interface [polypeptide binding]; other site 357348004038 phosphorylation site [posttranslational modification] 357348004039 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357348004040 ATP binding site [chemical binding]; other site 357348004041 Mg2+ binding site [ion binding]; other site 357348004042 G-X-G motif; other site 357348004043 Response regulator receiver domain; Region: Response_reg; pfam00072 357348004044 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348004045 active site 357348004046 phosphorylation site [posttranslational modification] 357348004047 intermolecular recognition site; other site 357348004048 dimerization interface [polypeptide binding]; other site 357348004049 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 357348004050 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348004051 active site 357348004052 phosphorylation site [posttranslational modification] 357348004053 intermolecular recognition site; other site 357348004054 dimerization interface [polypeptide binding]; other site 357348004055 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 357348004056 DNA binding residues [nucleotide binding] 357348004057 dimerization interface [polypeptide binding]; other site 357348004058 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 357348004059 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 357348004060 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348004061 putative substrate translocation pore; other site 357348004062 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 357348004063 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 357348004064 HlyD family secretion protein; Region: HlyD_3; pfam13437 357348004065 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 357348004066 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 357348004067 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 357348004068 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 357348004069 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 357348004070 acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397 357348004071 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 357348004072 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 357348004073 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 357348004074 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 357348004075 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 357348004076 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 357348004077 nudix motif; other site 357348004078 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 357348004079 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 357348004080 active site 357348004081 HIGH motif; other site 357348004082 nucleotide binding site [chemical binding]; other site 357348004083 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 357348004084 KMSKS motif; other site 357348004085 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 357348004086 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 357348004087 CoA-transferase family III; Region: CoA_transf_3; pfam02515 357348004088 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 357348004089 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 357348004090 motif 1; other site 357348004091 active site 357348004092 motif 2; other site 357348004093 motif 3; other site 357348004094 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 357348004095 DHHA1 domain; Region: DHHA1; pfam02272 357348004096 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357348004097 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348004098 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 357348004099 dimerization interface [polypeptide binding]; other site 357348004100 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348004101 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 357348004102 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 357348004103 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 357348004104 protein binding site [polypeptide binding]; other site 357348004105 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 357348004106 protein binding site [polypeptide binding]; other site 357348004107 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 357348004108 nudix motif; other site 357348004109 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 357348004110 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 357348004111 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 357348004112 putative active site [active] 357348004113 metal binding site [ion binding]; metal-binding site 357348004114 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 357348004115 active site 357348004116 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 357348004117 TM-ABC transporter signature motif; other site 357348004118 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 357348004119 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 357348004120 TM-ABC transporter signature motif; other site 357348004121 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 357348004122 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 357348004123 Walker A/P-loop; other site 357348004124 ATP binding site [chemical binding]; other site 357348004125 Q-loop/lid; other site 357348004126 ABC transporter signature motif; other site 357348004127 Walker B; other site 357348004128 D-loop; other site 357348004129 H-loop/switch region; other site 357348004130 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 357348004131 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 357348004132 Walker A/P-loop; other site 357348004133 ATP binding site [chemical binding]; other site 357348004134 Q-loop/lid; other site 357348004135 ABC transporter signature motif; other site 357348004136 Walker B; other site 357348004137 D-loop; other site 357348004138 H-loop/switch region; other site 357348004139 KduI/IolB family; Region: KduI; pfam04962 357348004140 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 357348004141 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 357348004142 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 357348004143 PYR/PP interface [polypeptide binding]; other site 357348004144 dimer interface [polypeptide binding]; other site 357348004145 TPP binding site [chemical binding]; other site 357348004146 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 357348004147 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 357348004148 TPP-binding site [chemical binding]; other site 357348004149 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 357348004150 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 357348004151 substrate binding site [chemical binding]; other site 357348004152 ATP binding site [chemical binding]; other site 357348004153 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 357348004154 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 357348004155 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 357348004156 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 357348004157 Walker A/P-loop; other site 357348004158 ATP binding site [chemical binding]; other site 357348004159 Q-loop/lid; other site 357348004160 ABC transporter signature motif; other site 357348004161 Walker B; other site 357348004162 D-loop; other site 357348004163 H-loop/switch region; other site 357348004164 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 357348004165 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 357348004166 TM-ABC transporter signature motif; other site 357348004167 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 357348004168 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 357348004169 putative ligand binding site [chemical binding]; other site 357348004170 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 357348004171 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 357348004172 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 357348004173 putative active site [active] 357348004174 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 357348004175 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 357348004176 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 357348004177 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 357348004178 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 357348004179 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 357348004180 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 357348004181 CPxP motif; other site 357348004182 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 357348004183 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348004184 active site 357348004185 phosphorylation site [posttranslational modification] 357348004186 intermolecular recognition site; other site 357348004187 dimerization interface [polypeptide binding]; other site 357348004188 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357348004189 DNA binding site [nucleotide binding] 357348004190 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4254 357348004191 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 357348004192 FecR protein; Region: FecR; pfam04773 357348004193 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 357348004194 CHASE2 domain; Region: CHASE2; pfam05226 357348004195 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 357348004196 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357348004197 dimer interface [polypeptide binding]; other site 357348004198 phosphorylation site [posttranslational modification] 357348004199 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357348004200 ATP binding site [chemical binding]; other site 357348004201 Mg2+ binding site [ion binding]; other site 357348004202 G-X-G motif; other site 357348004203 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 357348004204 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 357348004205 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 357348004206 active site 357348004207 tetramer interface; other site 357348004208 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 357348004209 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 357348004210 HIGH motif; other site 357348004211 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 357348004212 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 357348004213 active site 357348004214 KMSKS motif; other site 357348004215 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 357348004216 tRNA binding surface [nucleotide binding]; other site 357348004217 anticodon binding site; other site 357348004218 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 357348004219 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 357348004220 Part of AAA domain; Region: AAA_19; pfam13245 357348004221 Family description; Region: UvrD_C_2; pfam13538 357348004222 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 357348004223 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 357348004224 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348004225 Major Facilitator Superfamily; Region: MFS_1; pfam07690 357348004226 putative substrate translocation pore; other site 357348004227 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 357348004228 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 357348004229 dimer interface [polypeptide binding]; other site 357348004230 putative CheW interface [polypeptide binding]; other site 357348004231 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 357348004232 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 357348004233 HlyD family secretion protein; Region: HlyD_3; pfam13437 357348004234 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 357348004235 Fusaric acid resistance protein family; Region: FUSC; pfam04632 357348004236 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 357348004237 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 357348004238 transcriptional regulator; Provisional; Region: PRK10632 357348004239 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348004240 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 357348004241 putative effector binding pocket; other site 357348004242 dimerization interface [polypeptide binding]; other site 357348004243 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 357348004244 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 357348004245 active site 357348004246 metal binding site [ion binding]; metal-binding site 357348004247 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 357348004248 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 357348004249 FAD binding domain; Region: FAD_binding_4; pfam01565 357348004250 Predicted membrane protein (DUF2069); Region: DUF2069; pfam09842 357348004251 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 357348004252 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 357348004253 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 357348004254 Protein of unknown function (DUF962); Region: DUF962; cl01879 357348004255 FOG: CBS domain [General function prediction only]; Region: COG0517 357348004256 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 357348004257 acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814 357348004258 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 357348004259 putative acyl-acceptor binding pocket; other site 357348004260 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 357348004261 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 357348004262 Tetramer interface [polypeptide binding]; other site 357348004263 active site 357348004264 FMN-binding site [chemical binding]; other site 357348004265 putative transposase OrfB; Reviewed; Region: PHA02517 357348004266 HTH-like domain; Region: HTH_21; pfam13276 357348004267 Integrase core domain; Region: rve; pfam00665 357348004268 Integrase core domain; Region: rve_2; pfam13333 357348004269 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 357348004270 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 357348004271 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 357348004272 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 357348004273 short chain dehydrogenase; Provisional; Region: PRK06949 357348004274 classical (c) SDRs; Region: SDR_c; cd05233 357348004275 NAD(P) binding site [chemical binding]; other site 357348004276 active site 357348004277 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 357348004278 active site 357348004279 Uncharacterized protein conserved in bacteria (DUF2199); Region: DUF2199; cl02048 357348004280 PAS domain; Region: PAS_9; pfam13426 357348004281 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 357348004282 putative active site [active] 357348004283 heme pocket [chemical binding]; other site 357348004284 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 357348004285 DNA binding residues [nucleotide binding] 357348004286 dimerization interface [polypeptide binding]; other site 357348004287 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 357348004288 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 357348004289 short chain dehydrogenase; Provisional; Region: PRK07041 357348004290 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357348004291 NAD(P) binding site [chemical binding]; other site 357348004292 active site 357348004293 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 357348004294 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 357348004295 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 357348004296 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348004297 transcriptional activator TtdR; Provisional; Region: PRK09801 357348004298 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 357348004299 putative effector binding pocket; other site 357348004300 dimerization interface [polypeptide binding]; other site 357348004301 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 357348004302 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 357348004303 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 357348004304 homotrimer interaction site [polypeptide binding]; other site 357348004305 putative active site [active] 357348004306 HD domain; Region: HD_4; pfam13328 357348004307 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 357348004308 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 357348004309 synthetase active site [active] 357348004310 NTP binding site [chemical binding]; other site 357348004311 metal binding site [ion binding]; metal-binding site 357348004312 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 357348004313 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 357348004314 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 357348004315 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 357348004316 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 357348004317 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 357348004318 active site 357348004319 dimer interface [polypeptide binding]; other site 357348004320 motif 1; other site 357348004321 motif 2; other site 357348004322 motif 3; other site 357348004323 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 357348004324 anticodon binding site; other site 357348004325 translation initiation factor IF-3; Region: infC; TIGR00168 357348004326 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 357348004327 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 357348004328 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 357348004329 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 357348004330 23S rRNA binding site [nucleotide binding]; other site 357348004331 L21 binding site [polypeptide binding]; other site 357348004332 L13 binding site [polypeptide binding]; other site 357348004333 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 357348004334 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 357348004335 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 357348004336 dimer interface [polypeptide binding]; other site 357348004337 motif 1; other site 357348004338 active site 357348004339 motif 2; other site 357348004340 motif 3; other site 357348004341 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 357348004342 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 357348004343 putative tRNA-binding site [nucleotide binding]; other site 357348004344 B3/4 domain; Region: B3_4; pfam03483 357348004345 tRNA synthetase B5 domain; Region: B5; smart00874 357348004346 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 357348004347 dimer interface [polypeptide binding]; other site 357348004348 motif 1; other site 357348004349 motif 3; other site 357348004350 motif 2; other site 357348004351 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 357348004352 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 357348004353 IHF dimer interface [polypeptide binding]; other site 357348004354 IHF - DNA interface [nucleotide binding]; other site 357348004355 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 357348004356 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 357348004357 DNA binding residues [nucleotide binding] 357348004358 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 357348004359 Protein of unknown function (DUF3443); Region: DUF3443; pfam11925 357348004360 Protein of unknown function (DUF2844); Region: DUF2844; pfam11005 357348004361 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 357348004362 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 357348004363 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 357348004364 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 357348004365 outer membrane protein A; Reviewed; Region: PRK10808 357348004366 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 357348004367 Uncharacterized conserved protein [Function unknown]; Region: COG1434 357348004368 putative active site [active] 357348004369 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 357348004370 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357348004371 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348004372 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 357348004373 putative dimerization interface [polypeptide binding]; other site 357348004374 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 357348004375 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 357348004376 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 357348004377 RNA binding surface [nucleotide binding]; other site 357348004378 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 357348004379 probable active site [active] 357348004380 ribosome maturation protein RimP; Reviewed; Region: PRK00092 357348004381 Sm and related proteins; Region: Sm_like; cl00259 357348004382 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 357348004383 putative oligomer interface [polypeptide binding]; other site 357348004384 putative RNA binding site [nucleotide binding]; other site 357348004385 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 357348004386 NusA N-terminal domain; Region: NusA_N; pfam08529 357348004387 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 357348004388 RNA binding site [nucleotide binding]; other site 357348004389 homodimer interface [polypeptide binding]; other site 357348004390 NusA-like KH domain; Region: KH_5; pfam13184 357348004391 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 357348004392 G-X-X-G motif; other site 357348004393 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 357348004394 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 357348004395 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 357348004396 translation initiation factor IF-2; Region: IF-2; TIGR00487 357348004397 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 357348004398 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 357348004399 G1 box; other site 357348004400 putative GEF interaction site [polypeptide binding]; other site 357348004401 GTP/Mg2+ binding site [chemical binding]; other site 357348004402 Switch I region; other site 357348004403 G2 box; other site 357348004404 G3 box; other site 357348004405 Switch II region; other site 357348004406 G4 box; other site 357348004407 G5 box; other site 357348004408 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 357348004409 Translation-initiation factor 2; Region: IF-2; pfam11987 357348004410 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 357348004411 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 357348004412 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01851 357348004413 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 357348004414 RNA binding site [nucleotide binding]; other site 357348004415 active site 357348004416 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 357348004417 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 357348004418 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348004419 putative substrate translocation pore; other site 357348004420 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348004421 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 357348004422 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 357348004423 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 357348004424 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 357348004425 Transcriptional regulators [Transcription]; Region: MarR; COG1846 357348004426 MarR family; Region: MarR_2; pfam12802 357348004427 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 357348004428 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 357348004429 G1 box; other site 357348004430 putative GEF interaction site [polypeptide binding]; other site 357348004431 GTP/Mg2+ binding site [chemical binding]; other site 357348004432 Switch I region; other site 357348004433 G2 box; other site 357348004434 G3 box; other site 357348004435 Switch II region; other site 357348004436 G4 box; other site 357348004437 G5 box; other site 357348004438 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 357348004439 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 357348004440 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 357348004441 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 357348004442 TPP-binding site [chemical binding]; other site 357348004443 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 357348004444 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 357348004445 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 357348004446 E3 interaction surface; other site 357348004447 lipoyl attachment site [posttranslational modification]; other site 357348004448 e3 binding domain; Region: E3_binding; pfam02817 357348004449 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 357348004450 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 357348004451 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 357348004452 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 357348004453 Predicted ATPase [General function prediction only]; Region: COG1485 357348004454 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357348004455 Walker B; other site 357348004456 D-loop; other site 357348004457 H-loop/switch region; other site 357348004458 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 357348004459 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 357348004460 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 357348004461 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 357348004462 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 357348004463 Flp/Fap pilin component; Region: Flp_Fap; cl01585 357348004464 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 357348004465 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 357348004466 TadE-like protein; Region: TadE; pfam07811 357348004467 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 357348004468 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 357348004469 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 357348004470 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 357348004471 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 357348004472 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 357348004473 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 357348004474 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 357348004475 ATP binding site [chemical binding]; other site 357348004476 Walker A motif; other site 357348004477 hexamer interface [polypeptide binding]; other site 357348004478 Walker B motif; other site 357348004479 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 357348004480 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 357348004481 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 357348004482 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 357348004483 TPR repeat; Region: TPR_11; pfam13414 357348004484 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357348004485 binding surface 357348004486 TPR motif; other site 357348004487 Protein of unknown function (DUF3613); Region: DUF3613; pfam12266 357348004488 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 357348004489 Predicted membrane protein [Function unknown]; Region: COG4655 357348004490 Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977 357348004491 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 357348004492 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357348004493 Walker A motif; other site 357348004494 ATP binding site [chemical binding]; other site 357348004495 Walker B motif; other site 357348004496 arginine finger; other site 357348004497 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 357348004498 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 357348004499 bacterial Hfq-like; Region: Hfq; cd01716 357348004500 hexamer interface [polypeptide binding]; other site 357348004501 Sm1 motif; other site 357348004502 RNA binding site [nucleotide binding]; other site 357348004503 Sm2 motif; other site 357348004504 Protein of unknown function (DUF1571); Region: DUF1571; pfam07608 357348004505 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 357348004506 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 357348004507 acyl-activating enzyme (AAE) consensus motif; other site 357348004508 putative AMP binding site [chemical binding]; other site 357348004509 putative active site [active] 357348004510 putative CoA binding site [chemical binding]; other site 357348004511 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 357348004512 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 357348004513 putative sialic acid transporter; Region: 2A0112; TIGR00891 357348004514 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348004515 putative substrate translocation pore; other site 357348004516 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 357348004517 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 357348004518 Putative ParB-like nuclease; Region: ParBc_2; pfam08857 357348004519 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 357348004520 Sulfate transporter family; Region: Sulfate_transp; pfam00916 357348004521 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 357348004522 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 357348004523 metal binding site [ion binding]; metal-binding site 357348004524 Phosphoesterase family; Region: Phosphoesterase; pfam04185 357348004525 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 357348004526 dimer interface [polypeptide binding]; other site 357348004527 putative CheW interface [polypeptide binding]; other site 357348004528 ribonuclease R; Region: RNase_R; TIGR02063 357348004529 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 357348004530 RNB domain; Region: RNB; pfam00773 357348004531 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 357348004532 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 357348004533 RNA binding site [nucleotide binding]; other site 357348004534 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 357348004535 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 357348004536 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 357348004537 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 357348004538 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 357348004539 amidase catalytic site [active] 357348004540 Zn binding residues [ion binding]; other site 357348004541 substrate binding site [chemical binding]; other site 357348004542 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 357348004543 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 357348004544 tetramer (dimer of dimers) interface [polypeptide binding]; other site 357348004545 active site 357348004546 dimer interface [polypeptide binding]; other site 357348004547 Transcriptional regulators [Transcription]; Region: FadR; COG2186 357348004548 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 357348004549 DNA-binding site [nucleotide binding]; DNA binding site 357348004550 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 357348004551 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 357348004552 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 357348004553 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348004554 dimer interface [polypeptide binding]; other site 357348004555 conserved gate region; other site 357348004556 putative PBP binding loops; other site 357348004557 ABC-ATPase subunit interface; other site 357348004558 cystine transporter subunit; Provisional; Region: PRK11260 357348004559 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 357348004560 substrate binding pocket [chemical binding]; other site 357348004561 membrane-bound complex binding site; other site 357348004562 hinge residues; other site 357348004563 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 357348004564 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 357348004565 quinone interaction residues [chemical binding]; other site 357348004566 active site 357348004567 catalytic residues [active] 357348004568 FMN binding site [chemical binding]; other site 357348004569 substrate binding site [chemical binding]; other site 357348004570 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 357348004571 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 357348004572 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 357348004573 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 357348004574 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 357348004575 nudix motif; other site 357348004576 hypothetical protein; Provisional; Region: PRK02487 357348004577 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 357348004578 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 357348004579 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 357348004580 substrate binding site [chemical binding]; other site 357348004581 oxyanion hole (OAH) forming residues; other site 357348004582 trimer interface [polypeptide binding]; other site 357348004583 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 357348004584 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 357348004585 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 357348004586 active site 357348004587 dimer interface [polypeptide binding]; other site 357348004588 non-prolyl cis peptide bond; other site 357348004589 insertion regions; other site 357348004590 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 357348004591 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348004592 dimer interface [polypeptide binding]; other site 357348004593 conserved gate region; other site 357348004594 putative PBP binding loops; other site 357348004595 ABC-ATPase subunit interface; other site 357348004596 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 357348004597 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 357348004598 Walker A/P-loop; other site 357348004599 ATP binding site [chemical binding]; other site 357348004600 Q-loop/lid; other site 357348004601 ABC transporter signature motif; other site 357348004602 Walker B; other site 357348004603 D-loop; other site 357348004604 H-loop/switch region; other site 357348004605 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 357348004606 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 357348004607 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 357348004608 FMN binding site [chemical binding]; other site 357348004609 active site 357348004610 catalytic residues [active] 357348004611 substrate binding site [chemical binding]; other site 357348004612 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 357348004613 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 357348004614 Predicted transcriptional regulators [Transcription]; Region: COG1733 357348004615 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 357348004616 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 357348004617 CoenzymeA binding site [chemical binding]; other site 357348004618 subunit interaction site [polypeptide binding]; other site 357348004619 PHB binding site; other site 357348004620 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 357348004621 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 357348004622 active site 357348004623 catalytic tetrad [active] 357348004624 Predicted permease; Region: DUF318; cl17795 357348004625 ABC-2 type transporter; Region: ABC2_membrane; cl17235 357348004626 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 357348004627 nodulation ABC transporter NodI; Provisional; Region: PRK13537 357348004628 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 357348004629 Walker A/P-loop; other site 357348004630 ATP binding site [chemical binding]; other site 357348004631 Q-loop/lid; other site 357348004632 ABC transporter signature motif; other site 357348004633 Walker B; other site 357348004634 D-loop; other site 357348004635 H-loop/switch region; other site 357348004636 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 357348004637 Ligand Binding Site [chemical binding]; other site 357348004638 Protein of unknown function (DUF2939); Region: DUF2939; pfam11159 357348004639 LexA repressor; Validated; Region: PRK00215 357348004640 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 357348004641 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 357348004642 Catalytic site [active] 357348004643 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 357348004644 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 357348004645 substrate binding pocket [chemical binding]; other site 357348004646 membrane-bound complex binding site; other site 357348004647 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 357348004648 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348004649 dimer interface [polypeptide binding]; other site 357348004650 conserved gate region; other site 357348004651 putative PBP binding loops; other site 357348004652 ABC-ATPase subunit interface; other site 357348004653 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 357348004654 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348004655 dimer interface [polypeptide binding]; other site 357348004656 conserved gate region; other site 357348004657 putative PBP binding loops; other site 357348004658 ABC-ATPase subunit interface; other site 357348004659 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 357348004660 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 357348004661 Walker A/P-loop; other site 357348004662 ATP binding site [chemical binding]; other site 357348004663 Q-loop/lid; other site 357348004664 ABC transporter signature motif; other site 357348004665 Walker B; other site 357348004666 D-loop; other site 357348004667 H-loop/switch region; other site 357348004668 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12683 357348004669 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348004670 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 357348004671 substrate binding site [chemical binding]; other site 357348004672 dimerization interface [polypeptide binding]; other site 357348004673 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 357348004674 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 357348004675 ligand binding site [chemical binding]; other site 357348004676 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 357348004677 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 357348004678 Walker A/P-loop; other site 357348004679 ATP binding site [chemical binding]; other site 357348004680 Q-loop/lid; other site 357348004681 ABC transporter signature motif; other site 357348004682 Walker B; other site 357348004683 D-loop; other site 357348004684 H-loop/switch region; other site 357348004685 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 357348004686 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 357348004687 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 357348004688 TM-ABC transporter signature motif; other site 357348004689 Transcriptional regulators [Transcription]; Region: PurR; COG1609 357348004690 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 357348004691 DNA binding site [nucleotide binding] 357348004692 domain linker motif; other site 357348004693 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 357348004694 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 357348004695 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 357348004696 substrate binding site [chemical binding]; other site 357348004697 dimer interface [polypeptide binding]; other site 357348004698 ATP binding site [chemical binding]; other site 357348004699 Tar ligand binding domain homologue; Region: TarH; pfam02203 357348004700 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 357348004701 dimerization interface [polypeptide binding]; other site 357348004702 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 357348004703 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 357348004704 dimer interface [polypeptide binding]; other site 357348004705 putative CheW interface [polypeptide binding]; other site 357348004706 PrkA family serine protein kinase; Provisional; Region: PRK15455 357348004707 AAA ATPase domain; Region: AAA_16; pfam13191 357348004708 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 357348004709 hypothetical protein; Provisional; Region: PRK05325 357348004710 SpoVR family protein; Provisional; Region: PRK11767 357348004711 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 357348004712 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348004713 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 357348004714 putative substrate translocation pore; other site 357348004715 NMT1-like family; Region: NMT1_2; pfam13379 357348004716 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 357348004717 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 357348004718 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 357348004719 Walker A/P-loop; other site 357348004720 ATP binding site [chemical binding]; other site 357348004721 Q-loop/lid; other site 357348004722 ABC transporter signature motif; other site 357348004723 Walker B; other site 357348004724 D-loop; other site 357348004725 H-loop/switch region; other site 357348004726 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 357348004727 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 357348004728 Flp pilus assembly protein CpaB; Region: pilus_cpaB; TIGR03177 357348004729 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 357348004730 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 357348004731 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 357348004732 Pilus biogenesis CpaD protein (pilus_cpaD); Region: Pilus_CpaD; pfam09476 357348004733 AAA domain; Region: AAA_31; pfam13614 357348004734 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 357348004735 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 357348004736 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 357348004737 ATP binding site [chemical binding]; other site 357348004738 Walker A motif; other site 357348004739 hexamer interface [polypeptide binding]; other site 357348004740 Walker B motif; other site 357348004741 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 357348004742 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 357348004743 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 357348004744 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 357348004745 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 357348004746 binding surface 357348004747 TPR motif; other site 357348004748 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 357348004749 TadE-like protein; Region: TadE; pfam07811 357348004750 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 357348004751 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 357348004752 substrate binding pocket [chemical binding]; other site 357348004753 membrane-bound complex binding site; other site 357348004754 hinge residues; other site 357348004755 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348004756 dimer interface [polypeptide binding]; other site 357348004757 conserved gate region; other site 357348004758 putative PBP binding loops; other site 357348004759 ABC-ATPase subunit interface; other site 357348004760 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348004761 dimer interface [polypeptide binding]; other site 357348004762 conserved gate region; other site 357348004763 putative PBP binding loops; other site 357348004764 ABC-ATPase subunit interface; other site 357348004765 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 357348004766 Peptidase family M23; Region: Peptidase_M23; pfam01551 357348004767 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 357348004768 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 357348004769 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 357348004770 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 357348004771 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 357348004772 HlyD family secretion protein; Region: HlyD_3; pfam13437 357348004773 multidrug efflux protein; Reviewed; Region: PRK09577 357348004774 Protein export membrane protein; Region: SecD_SecF; cl14618 357348004775 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 357348004776 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 357348004777 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 357348004778 PapC N-terminal domain; Region: PapC_N; pfam13954 357348004779 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 357348004780 PapC C-terminal domain; Region: PapC_C; pfam13953 357348004781 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 357348004782 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 357348004783 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 357348004784 Fimbrial protein; Region: Fimbrial; pfam00419 357348004785 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 357348004786 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357348004787 Walker A/P-loop; other site 357348004788 ATP binding site [chemical binding]; other site 357348004789 Q-loop/lid; other site 357348004790 ABC transporter signature motif; other site 357348004791 Walker B; other site 357348004792 D-loop; other site 357348004793 H-loop/switch region; other site 357348004794 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 357348004795 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 357348004796 Ligand Binding Site [chemical binding]; other site 357348004797 Molecular Tunnel; other site 357348004798 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 357348004799 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 357348004800 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 357348004801 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357348004802 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 357348004803 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 357348004804 putative ligand binding site [chemical binding]; other site 357348004805 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 357348004806 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 357348004807 Walker A/P-loop; other site 357348004808 ATP binding site [chemical binding]; other site 357348004809 Q-loop/lid; other site 357348004810 ABC transporter signature motif; other site 357348004811 Walker B; other site 357348004812 D-loop; other site 357348004813 H-loop/switch region; other site 357348004814 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 357348004815 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 357348004816 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 357348004817 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 357348004818 TM-ABC transporter signature motif; other site 357348004819 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 357348004820 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 357348004821 NAD(P) binding site [chemical binding]; other site 357348004822 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 357348004823 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 357348004824 N- and C-terminal domain interface [polypeptide binding]; other site 357348004825 putative active site [active] 357348004826 MgATP binding site [chemical binding]; other site 357348004827 catalytic site [active] 357348004828 metal binding site [ion binding]; metal-binding site 357348004829 putative xylulose binding site [chemical binding]; other site 357348004830 putative homodimer interface [polypeptide binding]; other site 357348004831 short chain dehydrogenase; Provisional; Region: PRK07060 357348004832 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357348004833 NAD(P) binding site [chemical binding]; other site 357348004834 active site 357348004835 extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037 357348004836 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 357348004837 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 357348004838 DNA binding residues [nucleotide binding] 357348004839 MbtH-like protein; Region: MbtH; cl01279 357348004840 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 357348004841 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 357348004842 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 357348004843 Walker A/P-loop; other site 357348004844 ATP binding site [chemical binding]; other site 357348004845 Q-loop/lid; other site 357348004846 ABC transporter signature motif; other site 357348004847 Walker B; other site 357348004848 D-loop; other site 357348004849 H-loop/switch region; other site 357348004850 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 357348004851 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 357348004852 dimer interface [polypeptide binding]; other site 357348004853 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 357348004854 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 357348004855 ABC-ATPase subunit interface; other site 357348004856 dimer interface [polypeptide binding]; other site 357348004857 putative PBP binding regions; other site 357348004858 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 357348004859 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 357348004860 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 357348004861 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 357348004862 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 357348004863 siderophore binding site; other site 357348004864 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 357348004865 cyclic peptide transporter; Region: cyc_pep_trnsptr; TIGR01194 357348004866 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 357348004867 Walker A/P-loop; other site 357348004868 ATP binding site [chemical binding]; other site 357348004869 Q-loop/lid; other site 357348004870 ABC transporter signature motif; other site 357348004871 Walker B; other site 357348004872 D-loop; other site 357348004873 H-loop/switch region; other site 357348004874 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 357348004875 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 357348004876 acyl-activating enzyme (AAE) consensus motif; other site 357348004877 AMP binding site [chemical binding]; other site 357348004878 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 357348004879 Condensation domain; Region: Condensation; pfam00668 357348004880 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 357348004881 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 357348004882 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 357348004883 acyl-activating enzyme (AAE) consensus motif; other site 357348004884 AMP binding site [chemical binding]; other site 357348004885 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 357348004886 Condensation domain; Region: Condensation; pfam00668 357348004887 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 357348004888 Condensation domain; Region: Condensation; pfam00668 357348004889 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 357348004890 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 357348004891 acyl-activating enzyme (AAE) consensus motif; other site 357348004892 AMP binding site [chemical binding]; other site 357348004893 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 357348004894 Condensation domain; Region: Condensation; pfam00668 357348004895 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 357348004896 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 357348004897 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 357348004898 acyl-activating enzyme (AAE) consensus motif; other site 357348004899 AMP binding site [chemical binding]; other site 357348004900 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 357348004901 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 357348004902 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 357348004903 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 357348004904 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 357348004905 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 357348004906 N-terminal plug; other site 357348004907 ligand-binding site [chemical binding]; other site 357348004908 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 357348004909 catalytic site [active] 357348004910 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 357348004911 catalytic triad [active] 357348004912 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 357348004913 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 357348004914 homodimer interface [polypeptide binding]; other site 357348004915 Walker A motif; other site 357348004916 ATP binding site [chemical binding]; other site 357348004917 hydroxycobalamin binding site [chemical binding]; other site 357348004918 Walker B motif; other site 357348004919 cobalamin biosynthesis protein CbiG; Provisional; Region: PRK07027 357348004920 High-affinity nickel-transport protein; Region: NicO; cl00964 357348004921 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 357348004922 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 357348004923 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 357348004924 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 357348004925 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 357348004926 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 357348004927 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357348004928 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 357348004929 Walker A motif; other site 357348004930 ATP binding site [chemical binding]; other site 357348004931 Walker B motif; other site 357348004932 arginine finger; other site 357348004933 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 357348004934 metal ion-dependent adhesion site (MIDAS); other site 357348004935 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 357348004936 Serine hydrolase (FSH1); Region: FSH1; pfam03959 357348004937 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 357348004938 active site 357348004939 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 357348004940 aromatic chitin/cellulose binding site residues [chemical binding]; other site 357348004941 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 357348004942 aromatic chitin/cellulose binding site residues [chemical binding]; other site 357348004943 Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073 357348004944 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 357348004945 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 357348004946 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 357348004947 active site 357348004948 SAM binding site [chemical binding]; other site 357348004949 homodimer interface [polypeptide binding]; other site 357348004950 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 357348004951 active site 357348004952 SAM binding site [chemical binding]; other site 357348004953 homodimer interface [polypeptide binding]; other site 357348004954 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 357348004955 Precorrin-8X methylmutase; Region: CbiC; pfam02570 357348004956 precorrin-3B synthase; Region: CobG; TIGR02435 357348004957 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 357348004958 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 357348004959 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 357348004960 active site 357348004961 putative homodimer interface [polypeptide binding]; other site 357348004962 SAM binding site [chemical binding]; other site 357348004963 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 357348004964 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357348004965 S-adenosylmethionine binding site [chemical binding]; other site 357348004966 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 357348004967 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 357348004968 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 357348004969 active site 357348004970 SAM binding site [chemical binding]; other site 357348004971 homodimer interface [polypeptide binding]; other site 357348004972 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 357348004973 putative cyanate transporter; Provisional; Region: cynX; PRK09705 357348004974 MarR family; Region: MarR_2; cl17246 357348004975 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 357348004976 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 357348004977 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 357348004978 dimerization interface [polypeptide binding]; other site 357348004979 ligand binding site [chemical binding]; other site 357348004980 Transcriptional regulators [Transcription]; Region: MarR; COG1846 357348004981 MarR family; Region: MarR_2; pfam12802 357348004982 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 357348004983 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 357348004984 C-terminal domain interface [polypeptide binding]; other site 357348004985 GSH binding site (G-site) [chemical binding]; other site 357348004986 dimer interface [polypeptide binding]; other site 357348004987 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 357348004988 dimer interface [polypeptide binding]; other site 357348004989 N-terminal domain interface [polypeptide binding]; other site 357348004990 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357348004991 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348004992 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 357348004993 putative effector binding pocket; other site 357348004994 putative dimerization interface [polypeptide binding]; other site 357348004995 Domain of unknown function (DUF336); Region: DUF336; pfam03928 357348004996 short chain dehydrogenase; Provisional; Region: PRK09291 357348004997 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357348004998 NAD(P) binding site [chemical binding]; other site 357348004999 active site 357348005000 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 357348005001 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 357348005002 putative substrate binding site [chemical binding]; other site 357348005003 nucleotide binding site [chemical binding]; other site 357348005004 nucleotide binding site [chemical binding]; other site 357348005005 homodimer interface [polypeptide binding]; other site 357348005006 ornithine carbamoyltransferase; Validated; Region: PRK02102 357348005007 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 357348005008 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 357348005009 arginine deiminase; Provisional; Region: PRK01388 357348005010 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 357348005011 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348005012 ABC-ATPase subunit interface; other site 357348005013 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 357348005014 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357348005015 Walker A/P-loop; other site 357348005016 ATP binding site [chemical binding]; other site 357348005017 Q-loop/lid; other site 357348005018 ABC transporter signature motif; other site 357348005019 Walker B; other site 357348005020 D-loop; other site 357348005021 H-loop/switch region; other site 357348005022 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348005023 dimer interface [polypeptide binding]; other site 357348005024 conserved gate region; other site 357348005025 putative PBP binding loops; other site 357348005026 ABC-ATPase subunit interface; other site 357348005027 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 357348005028 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357348005029 S-adenosylmethionine binding site [chemical binding]; other site 357348005030 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348005031 putative substrate translocation pore; other site 357348005032 AMP-binding domain protein; Validated; Region: PRK07529 357348005033 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 357348005034 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_4; cd05944 357348005035 acyl-activating enzyme (AAE) consensus motif; other site 357348005036 putative AMP binding site [chemical binding]; other site 357348005037 putative active site [active] 357348005038 putative CoA binding site [chemical binding]; other site 357348005039 Protein of unknown function (DUF3562); Region: DUF3562; pfam12085 357348005040 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 357348005041 dimer interface [polypeptide binding]; other site 357348005042 putative CheW interface [polypeptide binding]; other site 357348005043 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 357348005044 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 357348005045 EamA-like transporter family; Region: EamA; pfam00892 357348005046 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 357348005047 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357348005048 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357348005049 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 357348005050 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 357348005051 trimer interface [polypeptide binding]; other site 357348005052 eyelet of channel; other site 357348005053 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 357348005054 Cupin-like domain; Region: Cupin_8; pfam13621 357348005055 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 357348005056 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 357348005057 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348005058 homodimer interface [polypeptide binding]; other site 357348005059 catalytic residue [active] 357348005060 Methyltransferase domain; Region: Methyltransf_23; pfam13489 357348005061 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357348005062 S-adenosylmethionine binding site [chemical binding]; other site 357348005063 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 357348005064 active site 357348005065 substrate binding site [chemical binding]; other site 357348005066 cosubstrate binding site; other site 357348005067 catalytic site [active] 357348005068 argininosuccinate synthase; Provisional; Region: PRK13820 357348005069 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 357348005070 ANP binding site [chemical binding]; other site 357348005071 Substrate Binding Site II [chemical binding]; other site 357348005072 Substrate Binding Site I [chemical binding]; other site 357348005073 argininosuccinate lyase; Provisional; Region: PRK00855 357348005074 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 357348005075 active sites [active] 357348005076 tetramer interface [polypeptide binding]; other site 357348005077 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 357348005078 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348005079 putative substrate translocation pore; other site 357348005080 Major Facilitator Superfamily; Region: MFS_1; pfam07690 357348005081 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 357348005082 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348005083 catalytic residue [active] 357348005084 dimer interface [polypeptide binding]; other site 357348005085 argininosuccinate lyase; Provisional; Region: PRK02186 357348005086 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 357348005087 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 357348005088 active sites [active] 357348005089 tetramer interface [polypeptide binding]; other site 357348005090 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 357348005091 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 357348005092 tetramer interface [polypeptide binding]; other site 357348005093 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348005094 catalytic residue [active] 357348005095 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 357348005096 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 357348005097 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 357348005098 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 357348005099 acyl-activating enzyme (AAE) consensus motif; other site 357348005100 active site 357348005101 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 357348005102 Condensation domain; Region: Condensation; pfam00668 357348005103 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 357348005104 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 357348005105 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 357348005106 acyl-activating enzyme (AAE) consensus motif; other site 357348005107 AMP binding site [chemical binding]; other site 357348005108 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 357348005109 Condensation domain; Region: Condensation; pfam00668 357348005110 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 357348005111 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 357348005112 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 357348005113 acyl-activating enzyme (AAE) consensus motif; other site 357348005114 AMP binding site [chemical binding]; other site 357348005115 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 357348005116 Condensation domain; Region: Condensation; pfam00668 357348005117 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 357348005118 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 357348005119 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 357348005120 acyl-activating enzyme (AAE) consensus motif; other site 357348005121 AMP binding site [chemical binding]; other site 357348005122 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 357348005123 Condensation domain; Region: Condensation; pfam00668 357348005124 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 357348005125 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 357348005126 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 357348005127 acyl-activating enzyme (AAE) consensus motif; other site 357348005128 AMP binding site [chemical binding]; other site 357348005129 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 357348005130 Condensation domain; Region: Condensation; pfam00668 357348005131 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 357348005132 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 357348005133 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 357348005134 acyl-activating enzyme (AAE) consensus motif; other site 357348005135 AMP binding site [chemical binding]; other site 357348005136 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 357348005137 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 357348005138 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 357348005139 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 357348005140 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 357348005141 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 357348005142 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 357348005143 active site 357348005144 Predicted integral membrane protein [Function unknown]; Region: COG5572 357348005145 hypothetical protein; Provisional; Region: PRK05409 357348005146 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 357348005147 Predicted membrane protein [Function unknown]; Region: COG2259 357348005148 Protein of unknown function (DUF1109); Region: DUF1109; pfam06532 357348005149 Protein of unknown function (DUF1109); Region: DUF1109; pfam06532 357348005150 RNA polymerase sigma factor; Provisional; Region: PRK12536 357348005151 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 357348005152 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 357348005153 DNA binding residues [nucleotide binding] 357348005154 Integrase core domain; Region: rve_3; cl15866 357348005155 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 357348005156 active site residue [active] 357348005157 allantoate amidohydrolase; Reviewed; Region: PRK12890 357348005158 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 357348005159 active site 357348005160 metal binding site [ion binding]; metal-binding site 357348005161 dimer interface [polypeptide binding]; other site 357348005162 allantoinase; Region: allantoinase; TIGR03178 357348005163 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 357348005164 active site 357348005165 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 357348005166 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348005167 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 357348005168 putative dimerization interface [polypeptide binding]; other site 357348005169 Protein of unknown function (DUF917); Region: DUF917; pfam06032 357348005170 urocanate hydratase; Provisional; Region: PRK05414 357348005171 metabolite-proton symporter; Region: 2A0106; TIGR00883 357348005172 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348005173 putative substrate translocation pore; other site 357348005174 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 357348005175 active sites [active] 357348005176 tetramer interface [polypeptide binding]; other site 357348005177 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 357348005178 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 357348005179 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 357348005180 trimer interface [polypeptide binding]; other site 357348005181 eyelet of channel; other site 357348005182 Protein of unknown function (DUF3443); Region: DUF3443; pfam11925 357348005183 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 357348005184 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348005185 active site 357348005186 phosphorylation site [posttranslational modification] 357348005187 intermolecular recognition site; other site 357348005188 dimerization interface [polypeptide binding]; other site 357348005189 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357348005190 DNA binding site [nucleotide binding] 357348005191 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 357348005192 ligand-binding site [chemical binding]; other site 357348005193 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357348005194 TPR motif; other site 357348005195 binding surface 357348005196 Methyltransferase domain; Region: Methyltransf_23; pfam13489 357348005197 Methyltransferase domain; Region: Methyltransf_11; pfam08241 357348005198 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357348005199 binding surface 357348005200 TPR motif; other site 357348005201 Tetratricopeptide repeat; Region: TPR_12; pfam13424 357348005202 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 357348005203 TPR repeat; Region: TPR_11; pfam13414 357348005204 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357348005205 binding surface 357348005206 TPR motif; other site 357348005207 TPR repeat; Region: TPR_11; pfam13414 357348005208 TPR repeat; Region: TPR_11; pfam13414 357348005209 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357348005210 TPR motif; other site 357348005211 binding surface 357348005212 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 357348005213 ADP-heptose:LPS heptosyl transferase I; Provisional; Region: PRK10964; cl15782 357348005214 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 357348005215 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 357348005216 HlyD family secretion protein; Region: HlyD_3; pfam13437 357348005217 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 357348005218 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 357348005219 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 357348005220 Walker A/P-loop; other site 357348005221 ATP binding site [chemical binding]; other site 357348005222 Q-loop/lid; other site 357348005223 ABC transporter signature motif; other site 357348005224 Walker B; other site 357348005225 D-loop; other site 357348005226 H-loop/switch region; other site 357348005227 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 357348005228 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 357348005229 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 357348005230 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 357348005231 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 357348005232 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 357348005233 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 357348005234 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 357348005235 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 357348005236 Family description; Region: VCBS; pfam13517 357348005237 Outer membrane efflux protein; Region: OEP; pfam02321 357348005238 Outer membrane efflux protein; Region: OEP; pfam02321 357348005239 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 357348005240 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 357348005241 ligand binding site [chemical binding]; other site 357348005242 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; cl17722 357348005243 DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834 357348005244 DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834 357348005245 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 357348005246 nucleophilic elbow; other site 357348005247 catalytic triad; other site 357348005248 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 357348005249 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 357348005250 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357348005251 dimer interface [polypeptide binding]; other site 357348005252 phosphorylation site [posttranslational modification] 357348005253 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357348005254 ATP binding site [chemical binding]; other site 357348005255 Mg2+ binding site [ion binding]; other site 357348005256 G-X-G motif; other site 357348005257 Response regulator receiver domain; Region: Response_reg; pfam00072 357348005258 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348005259 active site 357348005260 phosphorylation site [posttranslational modification] 357348005261 intermolecular recognition site; other site 357348005262 dimerization interface [polypeptide binding]; other site 357348005263 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 357348005264 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348005265 active site 357348005266 phosphorylation site [posttranslational modification] 357348005267 intermolecular recognition site; other site 357348005268 dimerization interface [polypeptide binding]; other site 357348005269 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 357348005270 DNA binding residues [nucleotide binding] 357348005271 dimerization interface [polypeptide binding]; other site 357348005272 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 357348005273 Haemagglutinin; Region: HIM; pfam05662 357348005274 YadA-like C-terminal region; Region: YadA; pfam03895 357348005275 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 357348005276 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 357348005277 PapC N-terminal domain; Region: PapC_N; pfam13954 357348005278 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 357348005279 PapC C-terminal domain; Region: PapC_C; pfam13953 357348005280 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 357348005281 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 357348005282 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 357348005283 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 357348005284 MEKHLA domain; Region: MEKHLA; pfam08670 357348005285 Esterase PHB depolymerase; Region: Esterase_phd; pfam10503 357348005286 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 357348005287 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 357348005288 dimer interface [polypeptide binding]; other site 357348005289 active site 357348005290 metal binding site [ion binding]; metal-binding site 357348005291 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 357348005292 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 357348005293 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 357348005294 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 357348005295 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 357348005296 iron-sulfur cluster [ion binding]; other site 357348005297 [2Fe-2S] cluster binding site [ion binding]; other site 357348005298 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 357348005299 dihydroxyacetone kinase; Provisional; Region: PRK14479 357348005300 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 357348005301 DAK2 domain; Region: Dak2; pfam02734 357348005302 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 357348005303 dimerization interface [polypeptide binding]; other site 357348005304 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 357348005305 dimer interface [polypeptide binding]; other site 357348005306 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 357348005307 putative CheW interface [polypeptide binding]; other site 357348005308 ABC-2 type transporter; Region: ABC2_membrane; cl17235 357348005309 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 357348005310 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 357348005311 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357348005312 Walker A/P-loop; other site 357348005313 ATP binding site [chemical binding]; other site 357348005314 Q-loop/lid; other site 357348005315 ABC transporter signature motif; other site 357348005316 Walker B; other site 357348005317 D-loop; other site 357348005318 H-loop/switch region; other site 357348005319 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 357348005320 ApbE family; Region: ApbE; pfam02424 357348005321 nitrous-oxide reductase; Validated; Region: PRK02888 357348005322 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 357348005323 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 357348005324 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 357348005325 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 357348005326 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 357348005327 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357348005328 Walker A/P-loop; other site 357348005329 ATP binding site [chemical binding]; other site 357348005330 Q-loop/lid; other site 357348005331 ABC transporter signature motif; other site 357348005332 Walker B; other site 357348005333 D-loop; other site 357348005334 H-loop/switch region; other site 357348005335 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 357348005336 NosL; Region: NosL; pfam05573 357348005337 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 357348005338 Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901 357348005339 ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163 357348005340 4Fe-4S binding domain; Region: Fer4_5; pfam12801 357348005341 4Fe-4S binding domain; Region: Fer4_5; pfam12801 357348005342 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 357348005343 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 357348005344 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 357348005345 Mechanosensitive ion channel; Region: MS_channel; pfam00924 357348005346 YciI-like protein; Reviewed; Region: PRK12866 357348005347 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 357348005348 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 357348005349 oligomer interface [polypeptide binding]; other site 357348005350 metal binding site [ion binding]; metal-binding site 357348005351 metal binding site [ion binding]; metal-binding site 357348005352 putative Cl binding site [ion binding]; other site 357348005353 basic sphincter; other site 357348005354 hydrophobic gate; other site 357348005355 periplasmic entrance; other site 357348005356 Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173 357348005357 AAA domain; Region: AAA_33; pfam13671 357348005358 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 357348005359 active site 357348005360 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 357348005361 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357348005362 Double zinc ribbon; Region: DZR; pfam12773 357348005363 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 357348005364 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 357348005365 AsnC family; Region: AsnC_trans_reg; pfam01037 357348005366 thioester reductase domain; Region: Thioester-redct; TIGR01746 357348005367 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357348005368 active site 357348005369 LTXXQ motif family protein; Region: LTXXQ; pfam07813 357348005370 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 357348005371 PGDYG protein; Region: PGDYG; pfam14083 357348005372 Protein of unknown function (DUF3022); Region: DUF3022; pfam11226 357348005373 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 357348005374 Transcriptional regulators [Transcription]; Region: PurR; COG1609 357348005375 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 357348005376 DNA binding site [nucleotide binding] 357348005377 domain linker motif; other site 357348005378 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 357348005379 putative ligand binding site [chemical binding]; other site 357348005380 putative dimerization interface [polypeptide binding]; other site 357348005381 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 357348005382 dimerization interface [polypeptide binding]; other site 357348005383 ligand binding site [chemical binding]; other site 357348005384 NADP binding site [chemical binding]; other site 357348005385 catalytic site [active] 357348005386 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348005387 D-galactonate transporter; Region: 2A0114; TIGR00893 357348005388 putative substrate translocation pore; other site 357348005389 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 357348005390 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 357348005391 substrate binding site [chemical binding]; other site 357348005392 ATP binding site [chemical binding]; other site 357348005393 SdpI/YhfL protein family; Region: SdpI; pfam13630 357348005394 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357348005395 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348005396 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 357348005397 dimerization interface [polypeptide binding]; other site 357348005398 Predicted membrane protein [Function unknown]; Region: COG2855 357348005399 putative voltage-gated ClC-type chloride channel ClcB; Provisional; Region: PRK01862 357348005400 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 357348005401 Cl- selectivity filter; other site 357348005402 Cl- binding residues [ion binding]; other site 357348005403 pore gating glutamate residue; other site 357348005404 dimer interface [polypeptide binding]; other site 357348005405 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 357348005406 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 357348005407 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 357348005408 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 357348005409 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 357348005410 HlyD family secretion protein; Region: HlyD_3; pfam13437 357348005411 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 357348005412 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 357348005413 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 357348005414 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 357348005415 DNA binding residues [nucleotide binding] 357348005416 putative dimer interface [polypeptide binding]; other site 357348005417 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 357348005418 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 357348005419 Predicted transcriptional regulator [Transcription]; Region: COG3655 357348005420 sequence-specific DNA binding site [nucleotide binding]; other site 357348005421 salt bridge; other site 357348005422 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 357348005423 PAS fold; Region: PAS_4; pfam08448 357348005424 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 357348005425 putative active site [active] 357348005426 heme pocket [chemical binding]; other site 357348005427 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357348005428 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 357348005429 Walker A motif; other site 357348005430 ATP binding site [chemical binding]; other site 357348005431 Walker B motif; other site 357348005432 arginine finger; other site 357348005433 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 357348005434 Putative phosphatase (DUF442); Region: DUF442; cl17385 357348005435 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 357348005436 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 357348005437 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 357348005438 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348005439 dimer interface [polypeptide binding]; other site 357348005440 conserved gate region; other site 357348005441 putative PBP binding loops; other site 357348005442 ABC-ATPase subunit interface; other site 357348005443 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348005444 dimer interface [polypeptide binding]; other site 357348005445 conserved gate region; other site 357348005446 putative PBP binding loops; other site 357348005447 ABC-ATPase subunit interface; other site 357348005448 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 357348005449 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357348005450 Walker A/P-loop; other site 357348005451 ATP binding site [chemical binding]; other site 357348005452 Q-loop/lid; other site 357348005453 ABC transporter signature motif; other site 357348005454 Walker B; other site 357348005455 D-loop; other site 357348005456 H-loop/switch region; other site 357348005457 TOBE domain; Region: TOBE_2; pfam08402 357348005458 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 357348005459 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 357348005460 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 357348005461 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 357348005462 Predicted Fe-S protein [General function prediction only]; Region: COG3313 357348005463 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 357348005464 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 357348005465 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 357348005466 FMN binding site [chemical binding]; other site 357348005467 substrate binding site [chemical binding]; other site 357348005468 putative catalytic residue [active] 357348005469 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 357348005470 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 357348005471 NAD binding site [chemical binding]; other site 357348005472 catalytic residues [active] 357348005473 Burkholderia Lethal Factor 1; Region: BPSL1549; cd12812 357348005474 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 357348005475 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 357348005476 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 357348005477 ABC transporter; Region: ABC_tran_2; pfam12848 357348005478 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 357348005479 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 357348005480 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 357348005481 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 357348005482 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357348005483 Walker A/P-loop; other site 357348005484 ATP binding site [chemical binding]; other site 357348005485 Q-loop/lid; other site 357348005486 ABC transporter signature motif; other site 357348005487 Walker B; other site 357348005488 D-loop; other site 357348005489 H-loop/switch region; other site 357348005490 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 357348005491 Domain of unknown function (DUF4072); Region: DUF4072; pfam13284 357348005492 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 357348005493 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 357348005494 motif II; other site 357348005495 cystathionine beta-lyase; Provisional; Region: PRK07050 357348005496 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 357348005497 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 357348005498 catalytic residue [active] 357348005499 beta-ketothiolase; Provisional; Region: PRK09051 357348005500 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 357348005501 dimer interface [polypeptide binding]; other site 357348005502 active site 357348005503 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 357348005504 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 357348005505 substrate binding site [chemical binding]; other site 357348005506 ATP binding site [chemical binding]; other site 357348005507 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 357348005508 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 357348005509 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 357348005510 FeS/SAM binding site; other site 357348005511 TRAM domain; Region: TRAM; cl01282 357348005512 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394 357348005513 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 357348005514 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 357348005515 acetyacetyl-CoA reductase; Provisional; Region: PRK12938 357348005516 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 357348005517 NAD(P) binding site [chemical binding]; other site 357348005518 homotetramer interface [polypeptide binding]; other site 357348005519 homodimer interface [polypeptide binding]; other site 357348005520 active site 357348005521 putative acyltransferase; Provisional; Region: PRK05790 357348005522 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 357348005523 dimer interface [polypeptide binding]; other site 357348005524 active site 357348005525 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 357348005526 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 357348005527 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 357348005528 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 357348005529 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 357348005530 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 357348005531 RNA binding surface [nucleotide binding]; other site 357348005532 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 357348005533 active site 357348005534 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 357348005535 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 357348005536 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 357348005537 DEAD_2; Region: DEAD_2; pfam06733 357348005538 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 357348005539 Protein of unknown function (DUF465); Region: DUF465; pfam04325 357348005540 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 357348005541 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 357348005542 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 357348005543 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 357348005544 RNA binding site [nucleotide binding]; other site 357348005545 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 357348005546 potassium uptake protein; Region: kup; TIGR00794 357348005547 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 357348005548 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 357348005549 active site 357348005550 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 357348005551 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 357348005552 GDP-binding site [chemical binding]; other site 357348005553 ACT binding site; other site 357348005554 IMP binding site; other site 357348005555 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 357348005556 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 357348005557 dimer interface [polypeptide binding]; other site 357348005558 motif 1; other site 357348005559 active site 357348005560 motif 2; other site 357348005561 motif 3; other site 357348005562 Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838 357348005563 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 357348005564 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 357348005565 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 357348005566 HflK protein; Region: hflK; TIGR01933 357348005567 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 357348005568 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 357348005569 HflX GTPase family; Region: HflX; cd01878 357348005570 G1 box; other site 357348005571 GTP/Mg2+ binding site [chemical binding]; other site 357348005572 Switch I region; other site 357348005573 G2 box; other site 357348005574 G3 box; other site 357348005575 Switch II region; other site 357348005576 G4 box; other site 357348005577 G5 box; other site 357348005578 bacterial Hfq-like; Region: Hfq; cd01716 357348005579 hexamer interface [polypeptide binding]; other site 357348005580 Sm1 motif; other site 357348005581 RNA binding site [nucleotide binding]; other site 357348005582 Sm2 motif; other site 357348005583 GTP-binding protein Der; Reviewed; Region: PRK00093 357348005584 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 357348005585 G1 box; other site 357348005586 GTP/Mg2+ binding site [chemical binding]; other site 357348005587 Switch I region; other site 357348005588 G2 box; other site 357348005589 Switch II region; other site 357348005590 G3 box; other site 357348005591 G4 box; other site 357348005592 G5 box; other site 357348005593 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 357348005594 G1 box; other site 357348005595 GTP/Mg2+ binding site [chemical binding]; other site 357348005596 Switch I region; other site 357348005597 G2 box; other site 357348005598 G3 box; other site 357348005599 Switch II region; other site 357348005600 G4 box; other site 357348005601 G5 box; other site 357348005602 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 357348005603 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 357348005604 Trp docking motif [polypeptide binding]; other site 357348005605 active site 357348005606 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 357348005607 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 357348005608 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 357348005609 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 357348005610 dimer interface [polypeptide binding]; other site 357348005611 motif 1; other site 357348005612 active site 357348005613 motif 2; other site 357348005614 motif 3; other site 357348005615 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 357348005616 anticodon binding site; other site 357348005617 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 357348005618 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 357348005619 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 357348005620 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 357348005621 non-specific DNA binding site [nucleotide binding]; other site 357348005622 salt bridge; other site 357348005623 sequence-specific DNA binding site [nucleotide binding]; other site 357348005624 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 357348005625 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 357348005626 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 357348005627 FeS/SAM binding site; other site 357348005628 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 357348005629 active site 357348005630 multimer interface [polypeptide binding]; other site 357348005631 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 357348005632 YccA-like proteins; Region: YccA_like; cd10433 357348005633 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 357348005634 TRAM domain; Region: TRAM; cl01282 357348005635 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357348005636 S-adenosylmethionine binding site [chemical binding]; other site 357348005637 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 357348005638 putative catalytic site [active] 357348005639 putative metal binding site [ion binding]; other site 357348005640 putative phosphate binding site [ion binding]; other site 357348005641 putative catalytic site [active] 357348005642 putative phosphate binding site [ion binding]; other site 357348005643 putative metal binding site [ion binding]; other site 357348005644 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 357348005645 active site 357348005646 catalytic site [active] 357348005647 substrate binding site [chemical binding]; other site 357348005648 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 357348005649 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 357348005650 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 357348005651 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 357348005652 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 357348005653 DNA binding residues [nucleotide binding] 357348005654 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 357348005655 Peptidase family M23; Region: Peptidase_M23; pfam01551 357348005656 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 357348005657 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357348005658 S-adenosylmethionine binding site [chemical binding]; other site 357348005659 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 357348005660 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 357348005661 CoA-transferase family III; Region: CoA_transf_3; pfam02515 357348005662 recombination protein RecR; Reviewed; Region: recR; PRK00076 357348005663 RecR protein; Region: RecR; pfam02132 357348005664 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 357348005665 putative active site [active] 357348005666 putative metal-binding site [ion binding]; other site 357348005667 tetramer interface [polypeptide binding]; other site 357348005668 hypothetical protein; Validated; Region: PRK00153 357348005669 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 357348005670 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357348005671 Walker A motif; other site 357348005672 ATP binding site [chemical binding]; other site 357348005673 Walker B motif; other site 357348005674 arginine finger; other site 357348005675 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 357348005676 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 357348005677 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 357348005678 catalytic residues [active] 357348005679 transcription termination factor Rho; Provisional; Region: rho; PRK09376 357348005680 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 357348005681 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 357348005682 RNA binding site [nucleotide binding]; other site 357348005683 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 357348005684 multimer interface [polypeptide binding]; other site 357348005685 Walker A motif; other site 357348005686 ATP binding site [chemical binding]; other site 357348005687 Walker B motif; other site 357348005688 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 357348005689 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 357348005690 DNA binding residues [nucleotide binding] 357348005691 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348005692 putative substrate translocation pore; other site 357348005693 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 357348005694 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167 357348005695 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 357348005696 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 357348005697 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 357348005698 putative efflux protein, MATE family; Region: matE; TIGR00797 357348005699 cation binding site [ion binding]; other site 357348005700 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 357348005701 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 357348005702 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 357348005703 DNA binding residues [nucleotide binding] 357348005704 putative dimer interface [polypeptide binding]; other site 357348005705 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 357348005706 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 357348005707 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 357348005708 Clp amino terminal domain; Region: Clp_N; pfam02861 357348005709 Clp amino terminal domain; Region: Clp_N; pfam02861 357348005710 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357348005711 Walker A motif; other site 357348005712 ATP binding site [chemical binding]; other site 357348005713 Walker B motif; other site 357348005714 arginine finger; other site 357348005715 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357348005716 Walker A motif; other site 357348005717 ATP binding site [chemical binding]; other site 357348005718 Walker B motif; other site 357348005719 arginine finger; other site 357348005720 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 357348005721 Transcriptional regulator; Region: Rrf2; cl17282 357348005722 Rrf2 family protein; Region: rrf2_super; TIGR00738 357348005723 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 357348005724 apolar tunnel; other site 357348005725 heme binding site [chemical binding]; other site 357348005726 dimerization interface [polypeptide binding]; other site 357348005727 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 357348005728 MoaE homodimer interface [polypeptide binding]; other site 357348005729 MoaD interaction [polypeptide binding]; other site 357348005730 active site residues [active] 357348005731 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 357348005732 MoaE interaction surface [polypeptide binding]; other site 357348005733 MoeB interaction surface [polypeptide binding]; other site 357348005734 thiocarboxylated glycine; other site 357348005735 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 357348005736 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 357348005737 dimer interface [polypeptide binding]; other site 357348005738 putative functional site; other site 357348005739 putative MPT binding site; other site 357348005740 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 357348005741 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 357348005742 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348005743 catalytic residue [active] 357348005744 homoserine dehydrogenase; Provisional; Region: PRK06349 357348005745 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 357348005746 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 357348005747 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 357348005748 aminotransferase AlaT; Validated; Region: PRK09265 357348005749 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 357348005750 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348005751 homodimer interface [polypeptide binding]; other site 357348005752 catalytic residue [active] 357348005753 Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome; Region: Xcc1710_like; cd05560 357348005754 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 357348005755 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 357348005756 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 357348005757 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 357348005758 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 357348005759 inhibitor-cofactor binding pocket; inhibition site 357348005760 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348005761 catalytic residue [active] 357348005762 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 357348005763 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 357348005764 Ligand binding site; other site 357348005765 Putative Catalytic site; other site 357348005766 DXD motif; other site 357348005767 putative formyltransferase; Provisional; Region: PRK06988 357348005768 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 357348005769 active site 357348005770 substrate binding site [chemical binding]; other site 357348005771 cosubstrate binding site; other site 357348005772 catalytic site [active] 357348005773 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 357348005774 active site 357348005775 NAD-dependent epimerase/dehydratase family protein; Provisional; Region: PRK11908 357348005776 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357348005777 NAD(P) binding site [chemical binding]; other site 357348005778 active site 357348005779 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 357348005780 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 357348005781 putative active site [active] 357348005782 putative catalytic site [active] 357348005783 putative Zn binding site [ion binding]; other site 357348005784 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 357348005785 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 357348005786 catalytic triad [active] 357348005787 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 357348005788 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 357348005789 putative active site [active] 357348005790 PhoH-like protein; Region: PhoH; pfam02562 357348005791 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 357348005792 NlpC/P60 family; Region: NLPC_P60; pfam00877 357348005793 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 357348005794 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 357348005795 replicative DNA helicase; Provisional; Region: PRK07004 357348005796 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 357348005797 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 357348005798 Walker A motif; other site 357348005799 ATP binding site [chemical binding]; other site 357348005800 Walker B motif; other site 357348005801 DNA binding loops [nucleotide binding] 357348005802 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 357348005803 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 357348005804 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 357348005805 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 357348005806 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 357348005807 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 357348005808 Putative zinc-finger; Region: zf-HC2; pfam13490 357348005809 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 357348005810 RNA polymerase sigma factor; Provisional; Region: PRK12533 357348005811 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 357348005812 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 357348005813 DNA binding residues [nucleotide binding] 357348005814 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 357348005815 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 357348005816 active site 357348005817 metal binding site [ion binding]; metal-binding site 357348005818 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 357348005819 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357348005820 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348005821 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 357348005822 putative effector binding pocket; other site 357348005823 dimerization interface [polypeptide binding]; other site 357348005824 glyoxylate carboligase; Provisional; Region: PRK11269 357348005825 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 357348005826 PYR/PP interface [polypeptide binding]; other site 357348005827 dimer interface [polypeptide binding]; other site 357348005828 TPP binding site [chemical binding]; other site 357348005829 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 357348005830 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 357348005831 TPP-binding site [chemical binding]; other site 357348005832 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 357348005833 tartronate semialdehyde reductase; Provisional; Region: PRK15059 357348005834 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 357348005835 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 357348005836 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 357348005837 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 357348005838 active site 357348005839 homodimer interface [polypeptide binding]; other site 357348005840 homotetramer interface [polypeptide binding]; other site 357348005841 psiF repeat; Region: PsiF_repeat; pfam07769 357348005842 psiF repeat; Region: PsiF_repeat; pfam07769 357348005843 Domain of unknown function DUF221; Region: DUF221; pfam02714 357348005844 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 357348005845 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 357348005846 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357348005847 putative ADP-binding pocket [chemical binding]; other site 357348005848 Predicted ATPase [General function prediction only]; Region: COG4637 357348005849 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357348005850 Walker A/P-loop; other site 357348005851 ATP binding site [chemical binding]; other site 357348005852 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 357348005853 Mechanosensitive ion channel; Region: MS_channel; pfam00924 357348005854 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 357348005855 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 357348005856 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 357348005857 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 357348005858 active site 357348005859 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 357348005860 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357348005861 Coenzyme A binding pocket [chemical binding]; other site 357348005862 DNA polymerase III subunit delta'; Validated; Region: PRK06964 357348005863 DNA polymerase III subunit delta'; Validated; Region: PRK08485 357348005864 thymidylate kinase; Validated; Region: tmk; PRK00698 357348005865 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 357348005866 TMP-binding site; other site 357348005867 ATP-binding site [chemical binding]; other site 357348005868 YceG-like family; Region: YceG; pfam02618 357348005869 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 357348005870 dimerization interface [polypeptide binding]; other site 357348005871 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 357348005872 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 357348005873 NRDE protein; Region: NRDE; cl01315 357348005874 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 357348005875 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357348005876 Coenzyme A binding pocket [chemical binding]; other site 357348005877 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 357348005878 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 357348005879 substrate binding pocket [chemical binding]; other site 357348005880 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 357348005881 Prostaglandin dehydrogenases; Region: PGDH; cd05288 357348005882 NAD(P) binding site [chemical binding]; other site 357348005883 substrate binding site [chemical binding]; other site 357348005884 dimer interface [polypeptide binding]; other site 357348005885 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 357348005886 CoenzymeA binding site [chemical binding]; other site 357348005887 subunit interaction site [polypeptide binding]; other site 357348005888 PHB binding site; other site 357348005889 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 357348005890 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 357348005891 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 357348005892 dimer interface [polypeptide binding]; other site 357348005893 active site 357348005894 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 357348005895 catalytic triad [active] 357348005896 metal binding site [ion binding]; metal-binding site 357348005897 conserved cis-peptide bond; other site 357348005898 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 357348005899 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 357348005900 substrate binding site [chemical binding]; other site 357348005901 oxyanion hole (OAH) forming residues; other site 357348005902 trimer interface [polypeptide binding]; other site 357348005903 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 357348005904 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 357348005905 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 357348005906 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 357348005907 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 357348005908 dimer interface [polypeptide binding]; other site 357348005909 acyl-activating enzyme (AAE) consensus motif; other site 357348005910 putative active site [active] 357348005911 AMP binding site [chemical binding]; other site 357348005912 putative CoA binding site [chemical binding]; other site 357348005913 Uncharacterized conserved protein [Function unknown]; Region: COG0397 357348005914 hypothetical protein; Validated; Region: PRK00029 357348005915 SelR domain; Region: SelR; pfam01641 357348005916 methionine sulfoxide reductase B; Provisional; Region: PRK00222 357348005917 intracellular septation protein A; Reviewed; Region: PRK00259 357348005918 BolA-like protein; Region: BolA; pfam01722 357348005919 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 357348005920 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 357348005921 Predicted acetyltransferase [General function prediction only]; Region: COG3153 357348005922 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 357348005923 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 357348005924 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 357348005925 dimerization interface [polypeptide binding]; other site 357348005926 ATP binding site [chemical binding]; other site 357348005927 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 357348005928 dimerization interface [polypeptide binding]; other site 357348005929 ATP binding site [chemical binding]; other site 357348005930 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 357348005931 putative active site [active] 357348005932 catalytic triad [active] 357348005933 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 357348005934 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 357348005935 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 357348005936 putative substrate binding site [chemical binding]; other site 357348005937 putative ATP binding site [chemical binding]; other site 357348005938 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 357348005939 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 357348005940 active site 357348005941 dimer interface [polypeptide binding]; other site 357348005942 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 357348005943 dimer interface [polypeptide binding]; other site 357348005944 active site 357348005945 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 357348005946 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 357348005947 Walker A/P-loop; other site 357348005948 ATP binding site [chemical binding]; other site 357348005949 Q-loop/lid; other site 357348005950 ABC transporter signature motif; other site 357348005951 Walker B; other site 357348005952 D-loop; other site 357348005953 H-loop/switch region; other site 357348005954 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 357348005955 active site 357348005956 catalytic triad [active] 357348005957 oxyanion hole [active] 357348005958 switch loop; other site 357348005959 SurA N-terminal domain; Region: SurA_N_3; cl07813 357348005960 periplasmic folding chaperone; Provisional; Region: PRK10788 357348005961 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 357348005962 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 357348005963 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 357348005964 30S subunit binding site; other site 357348005965 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 357348005966 Found in ATP-dependent protease La (LON); Region: LON; smart00464 357348005967 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357348005968 Walker A motif; other site 357348005969 ATP binding site [chemical binding]; other site 357348005970 Walker B motif; other site 357348005971 arginine finger; other site 357348005972 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 357348005973 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 357348005974 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 357348005975 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357348005976 Walker A motif; other site 357348005977 ATP binding site [chemical binding]; other site 357348005978 Walker B motif; other site 357348005979 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 357348005980 Clp protease; Region: CLP_protease; pfam00574 357348005981 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 357348005982 oligomer interface [polypeptide binding]; other site 357348005983 active site residues [active] 357348005984 trigger factor; Provisional; Region: tig; PRK01490 357348005985 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 357348005986 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 357348005987 Glycerate kinase family; Region: Gly_kinase; cl00841 357348005988 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 357348005989 MarR family; Region: MarR_2; pfam12802 357348005990 MarR family; Region: MarR_2; cl17246 357348005991 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 357348005992 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 357348005993 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 357348005994 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 357348005995 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 357348005996 dimerization interface [polypeptide binding]; other site 357348005997 DNA binding residues [nucleotide binding] 357348005998 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 357348005999 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 357348006000 trimer interface [polypeptide binding]; other site 357348006001 eyelet of channel; other site 357348006002 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_1; cd09996 357348006003 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 357348006004 active site 357348006005 Zn binding site [ion binding]; other site 357348006006 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 357348006007 PLD-like domain; Region: PLDc_2; pfam13091 357348006008 putative active site [active] 357348006009 catalytic site [active] 357348006010 Avidin family; Region: Avidin; pfam01382 357348006011 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 357348006012 PAAR motif; Region: PAAR_motif; pfam05488 357348006013 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 357348006014 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 357348006015 active site lid residues [active] 357348006016 substrate binding pocket [chemical binding]; other site 357348006017 catalytic residues [active] 357348006018 substrate-Mg2+ binding site; other site 357348006019 aspartate-rich region 1; other site 357348006020 aspartate-rich region 2; other site 357348006021 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 357348006022 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 357348006023 osmolarity response regulator; Provisional; Region: ompR; PRK09468 357348006024 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348006025 active site 357348006026 phosphorylation site [posttranslational modification] 357348006027 intermolecular recognition site; other site 357348006028 dimerization interface [polypeptide binding]; other site 357348006029 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357348006030 DNA binding site [nucleotide binding] 357348006031 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357348006032 HAMP domain; Region: HAMP; pfam00672 357348006033 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357348006034 dimer interface [polypeptide binding]; other site 357348006035 phosphorylation site [posttranslational modification] 357348006036 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357348006037 ATP binding site [chemical binding]; other site 357348006038 Mg2+ binding site [ion binding]; other site 357348006039 G-X-G motif; other site 357348006040 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 357348006041 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 357348006042 dimer interface [polypeptide binding]; other site 357348006043 decamer (pentamer of dimers) interface [polypeptide binding]; other site 357348006044 catalytic triad [active] 357348006045 peroxidatic and resolving cysteines [active] 357348006046 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 357348006047 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 357348006048 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 357348006049 homotrimer interaction site [polypeptide binding]; other site 357348006050 zinc binding site [ion binding]; other site 357348006051 CDP-binding sites; other site 357348006052 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 357348006053 substrate binding site; other site 357348006054 dimer interface; other site 357348006055 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 357348006056 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 357348006057 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 357348006058 ATP binding site [chemical binding]; other site 357348006059 putative Mg++ binding site [ion binding]; other site 357348006060 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 357348006061 nucleotide binding region [chemical binding]; other site 357348006062 ATP-binding site [chemical binding]; other site 357348006063 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 357348006064 acetylornithine deacetylase; Provisional; Region: PRK07522 357348006065 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 357348006066 metal binding site [ion binding]; metal-binding site 357348006067 putative dimer interface [polypeptide binding]; other site 357348006068 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 357348006069 tetramer interface [polypeptide binding]; other site 357348006070 hypothetical protein; Provisional; Region: PRK06815 357348006071 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348006072 catalytic residue [active] 357348006073 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 357348006074 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 357348006075 Transglycosylase; Region: Transgly; pfam00912 357348006076 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 357348006077 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 357348006078 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 357348006079 Tetratricopeptide repeat; Region: TPR_16; pfam13432 357348006080 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357348006081 TPR motif; other site 357348006082 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 357348006083 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 357348006084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 357348006085 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 357348006086 Dodecin; Region: Dodecin; pfam07311 357348006087 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357348006088 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348006089 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_4; cd08463 357348006090 putative substrate binding pocket [chemical binding]; other site 357348006091 putative dimerization interface [polypeptide binding]; other site 357348006092 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 357348006093 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 357348006094 active site 357348006095 putative substrate binding pocket [chemical binding]; other site 357348006096 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 357348006097 active site 357348006098 homotetramer interface [polypeptide binding]; other site 357348006099 Predicted membrane protein [Function unknown]; Region: COG3748 357348006100 Protein of unknown function (DUF989); Region: DUF989; pfam06181 357348006101 Cytochrome c; Region: Cytochrom_C; pfam00034 357348006102 ureidoglycolate hydrolase; Provisional; Region: PRK03606 357348006103 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 357348006104 allantoicase; Provisional; Region: PRK13257 357348006105 Allantoicase repeat; Region: Allantoicase; pfam03561 357348006106 Allantoicase repeat; Region: Allantoicase; pfam03561 357348006107 OHCU decarboxylase; Region: UHCUDC; TIGR03164 357348006108 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 357348006109 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 357348006110 active site 357348006111 catalytic site [active] 357348006112 tetramer interface [polypeptide binding]; other site 357348006113 Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126 357348006114 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 357348006115 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 357348006116 Na binding site [ion binding]; other site 357348006117 putative substrate binding site [chemical binding]; other site 357348006118 Transcriptional regulators [Transcription]; Region: GntR; COG1802 357348006119 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 357348006120 DNA-binding site [nucleotide binding]; DNA binding site 357348006121 FCD domain; Region: FCD; pfam07729 357348006122 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 357348006123 dimer interface [polypeptide binding]; other site 357348006124 catalytic triad [active] 357348006125 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 357348006126 nucleoside/Zn binding site; other site 357348006127 dimer interface [polypeptide binding]; other site 357348006128 catalytic motif [active] 357348006129 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 357348006130 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 357348006131 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 357348006132 active site 357348006133 metal binding site [ion binding]; metal-binding site 357348006134 AAA domain; Region: AAA_21; pfam13304 357348006135 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357348006136 ABC transporter signature motif; other site 357348006137 Walker B; other site 357348006138 D-loop; other site 357348006139 H-loop/switch region; other site 357348006140 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 357348006141 GMP synthase; Reviewed; Region: guaA; PRK00074 357348006142 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 357348006143 AMP/PPi binding site [chemical binding]; other site 357348006144 candidate oxyanion hole; other site 357348006145 catalytic triad [active] 357348006146 potential glutamine specificity residues [chemical binding]; other site 357348006147 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 357348006148 ATP Binding subdomain [chemical binding]; other site 357348006149 Ligand Binding sites [chemical binding]; other site 357348006150 Dimerization subdomain; other site 357348006151 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 357348006152 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 357348006153 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 357348006154 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 357348006155 active site 357348006156 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 357348006157 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 357348006158 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 357348006159 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2914 357348006160 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 357348006161 putative coenzyme Q binding site [chemical binding]; other site 357348006162 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 357348006163 SmpB-tmRNA interface; other site 357348006164 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 357348006165 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 357348006166 phosphoenolpyruvate synthase; Validated; Region: PRK06464 357348006167 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 357348006168 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 357348006169 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 357348006170 Phytochelatin synthase; Region: Phytochelatin; pfam05023 357348006171 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 357348006172 peptidase domain interface [polypeptide binding]; other site 357348006173 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 357348006174 active site 357348006175 catalytic triad [active] 357348006176 calcium binding site [ion binding]; other site 357348006177 PEP synthetase regulatory protein; Provisional; Region: PRK05339 357348006178 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 357348006179 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 357348006180 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 357348006181 RNA/DNA hybrid binding site [nucleotide binding]; other site 357348006182 active site 357348006183 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 357348006184 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 357348006185 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 357348006186 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 357348006187 active site 357348006188 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 357348006189 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 357348006190 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 357348006191 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 357348006192 trimer interface [polypeptide binding]; other site 357348006193 active site 357348006194 UDP-GlcNAc binding site [chemical binding]; other site 357348006195 lipid binding site [chemical binding]; lipid-binding site 357348006196 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 357348006197 periplasmic chaperone; Provisional; Region: PRK10780 357348006198 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 357348006199 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 357348006200 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 357348006201 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 357348006202 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 357348006203 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 357348006204 Surface antigen; Region: Bac_surface_Ag; pfam01103 357348006205 zinc metallopeptidase RseP; Provisional; Region: PRK10779 357348006206 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 357348006207 active site 357348006208 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 357348006209 protein binding site [polypeptide binding]; other site 357348006210 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 357348006211 putative substrate binding region [chemical binding]; other site 357348006212 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 357348006213 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK12464 357348006214 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 357348006215 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 357348006216 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 357348006217 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 357348006218 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 357348006219 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 357348006220 catalytic residue [active] 357348006221 putative FPP diphosphate binding site; other site 357348006222 putative FPP binding hydrophobic cleft; other site 357348006223 dimer interface [polypeptide binding]; other site 357348006224 putative IPP diphosphate binding site; other site 357348006225 ribosome recycling factor; Reviewed; Region: frr; PRK00083 357348006226 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 357348006227 hinge region; other site 357348006228 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 357348006229 putative nucleotide binding site [chemical binding]; other site 357348006230 uridine monophosphate binding site [chemical binding]; other site 357348006231 homohexameric interface [polypeptide binding]; other site 357348006232 elongation factor Ts; Provisional; Region: tsf; PRK09377 357348006233 UBA/TS-N domain; Region: UBA; pfam00627 357348006234 Elongation factor TS; Region: EF_TS; pfam00889 357348006235 Elongation factor TS; Region: EF_TS; pfam00889 357348006236 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 357348006237 rRNA interaction site [nucleotide binding]; other site 357348006238 S8 interaction site; other site 357348006239 putative laminin-1 binding site; other site 357348006240 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 357348006241 active site 357348006242 PII uridylyl-transferase; Provisional; Region: PRK03059 357348006243 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 357348006244 metal binding triad; other site 357348006245 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 357348006246 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 357348006247 Zn2+ binding site [ion binding]; other site 357348006248 Mg2+ binding site [ion binding]; other site 357348006249 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 357348006250 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 357348006251 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 357348006252 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 357348006253 RNA binding surface [nucleotide binding]; other site 357348006254 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 357348006255 active site 357348006256 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 357348006257 active site 357348006258 catalytic residues [active] 357348006259 metal binding site [ion binding]; metal-binding site 357348006260 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 357348006261 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 357348006262 nucleotide binding pocket [chemical binding]; other site 357348006263 K-X-D-G motif; other site 357348006264 catalytic site [active] 357348006265 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 357348006266 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 357348006267 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 357348006268 Dimer interface [polypeptide binding]; other site 357348006269 ZipA, C-terminal domain (FtsZ-binding); Region: ZipA_C; smart00771 357348006270 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 357348006271 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 357348006272 Walker A/P-loop; other site 357348006273 ATP binding site [chemical binding]; other site 357348006274 Q-loop/lid; other site 357348006275 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 357348006276 Q-loop/lid; other site 357348006277 ABC transporter signature motif; other site 357348006278 Walker B; other site 357348006279 D-loop; other site 357348006280 H-loop/switch region; other site 357348006281 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 357348006282 EamA-like transporter family; Region: EamA; pfam00892 357348006283 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 357348006284 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 357348006285 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348006286 homodimer interface [polypeptide binding]; other site 357348006287 catalytic residue [active] 357348006288 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 357348006289 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 357348006290 trimer interface [polypeptide binding]; other site 357348006291 active site 357348006292 substrate binding site [chemical binding]; other site 357348006293 CoA binding site [chemical binding]; other site 357348006294 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 357348006295 ArsC family; Region: ArsC; pfam03960 357348006296 putative catalytic residues [active] 357348006297 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 357348006298 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 357348006299 metal binding site [ion binding]; metal-binding site 357348006300 dimer interface [polypeptide binding]; other site 357348006301 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 357348006302 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357348006303 S-adenosylmethionine binding site [chemical binding]; other site 357348006304 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 357348006305 Putative catalytic domain, repeat 1, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_1; cd09155 357348006306 putative active site [active] 357348006307 catalytic site [active] 357348006308 Putative catalytic domain, repeat 2, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_2; cd09161 357348006309 putative active site [active] 357348006310 catalytic site [active] 357348006311 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 357348006312 catalytic residues [active] 357348006313 dimer interface [polypeptide binding]; other site 357348006314 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 357348006315 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 357348006316 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 357348006317 ABC transporter; Region: ABC_tran_2; pfam12848 357348006318 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 357348006319 Protein of unknown function (DUF2866); Region: DUF2866; pfam11065 357348006320 DNA repair protein RadA; Provisional; Region: PRK11823 357348006321 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 357348006322 Walker A motif/ATP binding site; other site 357348006323 ATP binding site [chemical binding]; other site 357348006324 Walker B motif; other site 357348006325 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 357348006326 alanine racemase; Reviewed; Region: dadX; PRK03646 357348006327 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 357348006328 active site 357348006329 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 357348006330 substrate binding site [chemical binding]; other site 357348006331 catalytic residues [active] 357348006332 dimer interface [polypeptide binding]; other site 357348006333 lysophospholipid transporter LplT; Provisional; Region: PRK11195 357348006334 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348006335 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 357348006336 dimer interface [polypeptide binding]; other site 357348006337 substrate binding site [chemical binding]; other site 357348006338 ATP binding site [chemical binding]; other site 357348006339 Domain of unknown function (DUF1853); Region: DUF1853; pfam08907 357348006340 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 357348006341 Fe-S cluster binding site [ion binding]; other site 357348006342 active site 357348006343 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 357348006344 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357348006345 Coenzyme A binding pocket [chemical binding]; other site 357348006346 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 357348006347 Glycoprotease family; Region: Peptidase_M22; pfam00814 357348006348 Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a...; Region: ACBP; cl00221 357348006349 acyl-CoA binding pocket [chemical binding]; other site 357348006350 CoA binding site [chemical binding]; other site 357348006351 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 357348006352 DEAD-like helicases superfamily; Region: DEXDc; smart00487 357348006353 ATP binding site [chemical binding]; other site 357348006354 Mg++ binding site [ion binding]; other site 357348006355 motif III; other site 357348006356 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 357348006357 nucleotide binding region [chemical binding]; other site 357348006358 ATP-binding site [chemical binding]; other site 357348006359 isocitrate lyase; Provisional; Region: PRK15063 357348006360 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 357348006361 tetramer interface [polypeptide binding]; other site 357348006362 active site 357348006363 Mg2+/Mn2+ binding site [ion binding]; other site 357348006364 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 357348006365 Ligand Binding Site [chemical binding]; other site 357348006366 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357348006367 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 357348006368 putative effector binding pocket; other site 357348006369 dimerization interface [polypeptide binding]; other site 357348006370 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 357348006371 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 357348006372 motif II; other site 357348006373 malate synthase A; Region: malate_syn_A; TIGR01344 357348006374 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 357348006375 active site 357348006376 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 357348006377 putative active site pocket [active] 357348006378 dimerization interface [polypeptide binding]; other site 357348006379 putative catalytic residue [active] 357348006380 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 357348006381 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 357348006382 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 357348006383 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357348006384 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357348006385 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357348006386 Coenzyme A binding pocket [chemical binding]; other site 357348006387 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 357348006388 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 357348006389 active site 357348006390 HIGH motif; other site 357348006391 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 357348006392 active site 357348006393 KMSKS motif; other site 357348006394 hypothetical protein; Provisional; Region: PRK10279 357348006395 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 357348006396 nucleophile elbow; other site 357348006397 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 357348006398 NlpC/P60 family; Region: NLPC_P60; pfam00877 357348006399 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 357348006400 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 357348006401 Walker A/P-loop; other site 357348006402 ATP binding site [chemical binding]; other site 357348006403 Q-loop/lid; other site 357348006404 ABC transporter signature motif; other site 357348006405 Walker B; other site 357348006406 D-loop; other site 357348006407 H-loop/switch region; other site 357348006408 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 357348006409 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 357348006410 Walker A/P-loop; other site 357348006411 ATP binding site [chemical binding]; other site 357348006412 Q-loop/lid; other site 357348006413 ABC transporter signature motif; other site 357348006414 Walker B; other site 357348006415 D-loop; other site 357348006416 H-loop/switch region; other site 357348006417 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 357348006418 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 357348006419 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348006420 dimer interface [polypeptide binding]; other site 357348006421 conserved gate region; other site 357348006422 putative PBP binding loops; other site 357348006423 ABC-ATPase subunit interface; other site 357348006424 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 357348006425 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348006426 dimer interface [polypeptide binding]; other site 357348006427 conserved gate region; other site 357348006428 putative PBP binding loops; other site 357348006429 ABC-ATPase subunit interface; other site 357348006430 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 357348006431 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 357348006432 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06997 357348006433 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 357348006434 NAD binding site [chemical binding]; other site 357348006435 homotetramer interface [polypeptide binding]; other site 357348006436 homodimer interface [polypeptide binding]; other site 357348006437 substrate binding site [chemical binding]; other site 357348006438 active site 357348006439 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 357348006440 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 357348006441 putative [Fe4-S4] binding site [ion binding]; other site 357348006442 putative molybdopterin cofactor binding site [chemical binding]; other site 357348006443 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 357348006444 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 357348006445 putative molybdopterin cofactor binding site; other site 357348006446 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 357348006447 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 357348006448 FAD binding pocket [chemical binding]; other site 357348006449 FAD binding motif [chemical binding]; other site 357348006450 phosphate binding motif [ion binding]; other site 357348006451 beta-alpha-beta structure motif; other site 357348006452 NAD binding pocket [chemical binding]; other site 357348006453 Ferredoxin [Energy production and conversion]; Region: COG1146 357348006454 4Fe-4S binding domain; Region: Fer4; pfam00037 357348006455 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 357348006456 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 357348006457 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 357348006458 active site 357348006459 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 357348006460 argininosuccinate lyase; Provisional; Region: PRK02186 357348006461 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 357348006462 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 357348006463 active sites [active] 357348006464 tetramer interface [polypeptide binding]; other site 357348006465 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 357348006466 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348006467 catalytic residue [active] 357348006468 dimer interface [polypeptide binding]; other site 357348006469 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 357348006470 G1 box; other site 357348006471 GTP/Mg2+ binding site [chemical binding]; other site 357348006472 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 357348006473 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 357348006474 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 357348006475 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 357348006476 Active Sites [active] 357348006477 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 357348006478 active site 357348006479 phosphoserine aminotransferase; Provisional; Region: PRK12462 357348006480 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 357348006481 catalytic residue [active] 357348006482 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 357348006483 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 357348006484 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 357348006485 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 357348006486 PYR/PP interface [polypeptide binding]; other site 357348006487 dimer interface [polypeptide binding]; other site 357348006488 TPP binding site [chemical binding]; other site 357348006489 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 357348006490 TPP-binding site [chemical binding]; other site 357348006491 dimer interface [polypeptide binding]; other site 357348006492 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 357348006493 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357348006494 S-adenosylmethionine binding site [chemical binding]; other site 357348006495 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 357348006496 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 357348006497 active site 357348006498 iron coordination sites [ion binding]; other site 357348006499 substrate binding pocket [chemical binding]; other site 357348006500 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 357348006501 Condensation domain; Region: Condensation; pfam00668 357348006502 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 357348006503 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 357348006504 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 357348006505 acyl-activating enzyme (AAE) consensus motif; other site 357348006506 AMP binding site [chemical binding]; other site 357348006507 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 357348006508 Condensation domain; Region: Condensation; pfam00668 357348006509 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 357348006510 Condensation domain; Region: Condensation; pfam00668 357348006511 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 357348006512 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 357348006513 acyl-activating enzyme (AAE) consensus motif; other site 357348006514 AMP binding site [chemical binding]; other site 357348006515 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 357348006516 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 357348006517 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 357348006518 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 357348006519 Transmembrane secretion effector; Region: MFS_3; pfam05977 357348006520 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348006521 putative substrate translocation pore; other site 357348006522 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 357348006523 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 357348006524 acyl-activating enzyme (AAE) consensus motif; other site 357348006525 AMP binding site [chemical binding]; other site 357348006526 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 357348006527 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 357348006528 ligand-binding site [chemical binding]; other site 357348006529 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 357348006530 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 357348006531 HlyD family secretion protein; Region: HlyD_3; pfam13437 357348006532 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 357348006533 Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846 357348006534 active site 357348006535 catalytic triad [active] 357348006536 oxyanion hole [active] 357348006537 Autotransporter beta-domain; Region: Autotransporter; smart00869 357348006538 aspartate kinase; Reviewed; Region: PRK06635 357348006539 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 357348006540 putative nucleotide binding site [chemical binding]; other site 357348006541 putative catalytic residues [active] 357348006542 putative Mg ion binding site [ion binding]; other site 357348006543 putative aspartate binding site [chemical binding]; other site 357348006544 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 357348006545 putative allosteric regulatory site; other site 357348006546 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 357348006547 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 357348006548 Ligand Binding Site [chemical binding]; other site 357348006549 TilS substrate binding domain; Region: TilS; pfam09179 357348006550 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 357348006551 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 357348006552 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 357348006553 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 357348006554 endonuclease III; Region: ENDO3c; smart00478 357348006555 minor groove reading motif; other site 357348006556 helix-hairpin-helix signature motif; other site 357348006557 substrate binding pocket [chemical binding]; other site 357348006558 active site 357348006559 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 357348006560 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 357348006561 active site 357348006562 HIGH motif; other site 357348006563 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 357348006564 KMSKS motif; other site 357348006565 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 357348006566 tRNA binding surface [nucleotide binding]; other site 357348006567 anticodon binding site; other site 357348006568 TPR repeat; Region: TPR_11; pfam13414 357348006569 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357348006570 binding surface 357348006571 TPR motif; other site 357348006572 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 357348006573 substrate binding site [chemical binding]; other site 357348006574 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 357348006575 substrate binding site [chemical binding]; other site 357348006576 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 357348006577 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 357348006578 putative active site [active] 357348006579 putative metal binding site [ion binding]; other site 357348006580 serine O-acetyltransferase; Region: cysE; TIGR01172 357348006581 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 357348006582 trimer interface [polypeptide binding]; other site 357348006583 active site 357348006584 substrate binding site [chemical binding]; other site 357348006585 CoA binding site [chemical binding]; other site 357348006586 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 357348006587 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 357348006588 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 357348006589 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 357348006590 active site 357348006591 dimerization interface [polypeptide binding]; other site 357348006592 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 357348006593 Transposase; Region: DDE_Tnp_ISL3; pfam01610 357348006594 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 357348006595 MutS domain I; Region: MutS_I; pfam01624 357348006596 MutS domain II; Region: MutS_II; pfam05188 357348006597 MutS domain III; Region: MutS_III; pfam05192 357348006598 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 357348006599 Walker A/P-loop; other site 357348006600 ATP binding site [chemical binding]; other site 357348006601 Q-loop/lid; other site 357348006602 ABC transporter signature motif; other site 357348006603 Walker B; other site 357348006604 D-loop; other site 357348006605 H-loop/switch region; other site 357348006606 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 357348006607 Uncharacterized conserved protein [Function unknown]; Region: COG2850 357348006608 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 357348006609 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 357348006610 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 357348006611 dihydrodipicolinate synthase; Region: dapA; TIGR00674 357348006612 dimer interface [polypeptide binding]; other site 357348006613 active site 357348006614 catalytic residue [active] 357348006615 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 357348006616 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 357348006617 active site 357348006618 HIGH motif; other site 357348006619 dimer interface [polypeptide binding]; other site 357348006620 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 357348006621 active site 357348006622 KMSKS motif; other site 357348006623 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 357348006624 Peptidase family M50; Region: Peptidase_M50; pfam02163 357348006625 active site 357348006626 putative substrate binding region [chemical binding]; other site 357348006627 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 357348006628 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 357348006629 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 357348006630 active site 357348006631 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 357348006632 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 357348006633 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 357348006634 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 357348006635 catalytic site [active] 357348006636 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 357348006637 dinuclear metal binding motif [ion binding]; other site 357348006638 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 357348006639 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 357348006640 trimer interface [polypeptide binding]; other site 357348006641 putative metal binding site [ion binding]; other site 357348006642 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 357348006643 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 357348006644 dimerization interface [polypeptide binding]; other site 357348006645 domain crossover interface; other site 357348006646 redox-dependent activation switch; other site 357348006647 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 357348006648 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 357348006649 enolase; Provisional; Region: eno; PRK00077 357348006650 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 357348006651 dimer interface [polypeptide binding]; other site 357348006652 metal binding site [ion binding]; metal-binding site 357348006653 substrate binding pocket [chemical binding]; other site 357348006654 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 357348006655 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 357348006656 CTP synthetase; Validated; Region: pyrG; PRK05380 357348006657 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 357348006658 Catalytic site [active] 357348006659 active site 357348006660 UTP binding site [chemical binding]; other site 357348006661 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 357348006662 active site 357348006663 putative oxyanion hole; other site 357348006664 catalytic triad [active] 357348006665 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 357348006666 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 357348006667 nucleophilic elbow; other site 357348006668 catalytic triad; other site 357348006669 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 357348006670 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 357348006671 Competence protein; Region: Competence; pfam03772 357348006672 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 357348006673 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 357348006674 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 357348006675 active site 357348006676 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 357348006677 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 357348006678 Walker A/P-loop; other site 357348006679 ATP binding site [chemical binding]; other site 357348006680 Q-loop/lid; other site 357348006681 ABC transporter signature motif; other site 357348006682 Walker B; other site 357348006683 D-loop; other site 357348006684 H-loop/switch region; other site 357348006685 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 357348006686 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 357348006687 FtsX-like permease family; Region: FtsX; pfam02687 357348006688 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4255 357348006689 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 357348006690 DHH family; Region: DHH; pfam01368 357348006691 DHHA1 domain; Region: DHHA1; pfam02272 357348006692 peptide chain release factor 2; Validated; Region: prfB; PRK00578 357348006693 This domain is found in peptide chain release factors; Region: PCRF; smart00937 357348006694 RF-1 domain; Region: RF-1; pfam00472 357348006695 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 357348006696 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 357348006697 dimer interface [polypeptide binding]; other site 357348006698 putative anticodon binding site; other site 357348006699 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 357348006700 motif 1; other site 357348006701 active site 357348006702 motif 2; other site 357348006703 motif 3; other site 357348006704 FeS assembly protein IscX; Region: iscX_yfhJ; TIGR03412 357348006705 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 357348006706 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 357348006707 catalytic loop [active] 357348006708 iron binding site [ion binding]; other site 357348006709 chaperone protein HscA; Provisional; Region: hscA; PRK05183 357348006710 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 357348006711 nucleotide binding site [chemical binding]; other site 357348006712 putative NEF/HSP70 interaction site [polypeptide binding]; other site 357348006713 SBD interface [polypeptide binding]; other site 357348006714 co-chaperone HscB; Provisional; Region: hscB; PRK03578 357348006715 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 357348006716 HSP70 interaction site [polypeptide binding]; other site 357348006717 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 357348006718 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 357348006719 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 357348006720 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 357348006721 trimerization site [polypeptide binding]; other site 357348006722 active site 357348006723 cysteine desulfurase; Provisional; Region: PRK14012 357348006724 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 357348006725 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 357348006726 catalytic residue [active] 357348006727 Predicted transcriptional regulator [Transcription]; Region: COG1959 357348006728 iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010 357348006729 Low molecular weight phosphatase family; Region: LMWPc; cd00115 357348006730 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 357348006731 active site 357348006732 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 357348006733 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 357348006734 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 357348006735 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 357348006736 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 357348006737 Cysteine-rich domain; Region: CCG; pfam02754 357348006738 Cysteine-rich domain; Region: CCG; pfam02754 357348006739 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 357348006740 Transcriptional regulator [Transcription]; Region: IclR; COG1414 357348006741 Bacterial transcriptional regulator; Region: IclR; pfam01614 357348006742 Transposase domain (DUF772); Region: DUF772; pfam05598 357348006743 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 357348006744 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 357348006745 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 357348006746 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 357348006747 Phasin protein; Region: Phasin_2; pfam09361 357348006748 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 357348006749 E3 interaction surface; other site 357348006750 lipoyl attachment site [posttranslational modification]; other site 357348006751 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 357348006752 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 357348006753 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 357348006754 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 357348006755 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 357348006756 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 357348006757 E3 interaction surface; other site 357348006758 lipoyl attachment site [posttranslational modification]; other site 357348006759 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 357348006760 E3 interaction surface; other site 357348006761 lipoyl attachment site [posttranslational modification]; other site 357348006762 e3 binding domain; Region: E3_binding; pfam02817 357348006763 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 357348006764 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 357348006765 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 357348006766 dimer interface [polypeptide binding]; other site 357348006767 TPP-binding site [chemical binding]; other site 357348006768 PAS domain S-box; Region: sensory_box; TIGR00229 357348006769 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 357348006770 putative active site [active] 357348006771 heme pocket [chemical binding]; other site 357348006772 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357348006773 dimer interface [polypeptide binding]; other site 357348006774 phosphorylation site [posttranslational modification] 357348006775 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357348006776 ATP binding site [chemical binding]; other site 357348006777 Mg2+ binding site [ion binding]; other site 357348006778 G-X-G motif; other site 357348006779 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 357348006780 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348006781 active site 357348006782 phosphorylation site [posttranslational modification] 357348006783 intermolecular recognition site; other site 357348006784 dimerization interface [polypeptide binding]; other site 357348006785 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 357348006786 DNA binding residues [nucleotide binding] 357348006787 dimerization interface [polypeptide binding]; other site 357348006788 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14189 357348006789 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 357348006790 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 357348006791 homodimer interface [polypeptide binding]; other site 357348006792 NADP binding site [chemical binding]; other site 357348006793 substrate binding site [chemical binding]; other site 357348006794 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 357348006795 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 357348006796 active site 357348006797 Zn binding site [ion binding]; other site 357348006798 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 357348006799 active site 357348006800 DNA polymerase IV; Validated; Region: PRK02406 357348006801 DNA binding site [nucleotide binding] 357348006802 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 357348006803 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348006804 putative substrate translocation pore; other site 357348006805 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 357348006806 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348006807 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 357348006808 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 357348006809 [4Fe-4S] binding site [ion binding]; other site 357348006810 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 357348006811 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 357348006812 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 357348006813 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 357348006814 molybdopterin cofactor binding site; other site 357348006815 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 357348006816 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 357348006817 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 357348006818 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 357348006819 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 357348006820 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 357348006821 dimerization interface [polypeptide binding]; other site 357348006822 GAF domain; Region: GAF; pfam01590 357348006823 Histidine kinase; Region: HisKA_3; pfam07730 357348006824 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357348006825 ATP binding site [chemical binding]; other site 357348006826 Mg2+ binding site [ion binding]; other site 357348006827 G-X-G motif; other site 357348006828 transcriptional regulator NarL; Provisional; Region: PRK10651 357348006829 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348006830 active site 357348006831 phosphorylation site [posttranslational modification] 357348006832 intermolecular recognition site; other site 357348006833 dimerization interface [polypeptide binding]; other site 357348006834 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 357348006835 DNA binding residues [nucleotide binding] 357348006836 dimerization interface [polypeptide binding]; other site 357348006837 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 357348006838 putative catalytic site [active] 357348006839 putative phosphate binding site [ion binding]; other site 357348006840 active site 357348006841 metal binding site A [ion binding]; metal-binding site 357348006842 DNA binding site [nucleotide binding] 357348006843 putative AP binding site [nucleotide binding]; other site 357348006844 putative metal binding site B [ion binding]; other site 357348006845 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 357348006846 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348006847 active site 357348006848 phosphorylation site [posttranslational modification] 357348006849 intermolecular recognition site; other site 357348006850 dimerization interface [polypeptide binding]; other site 357348006851 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357348006852 Walker A motif; other site 357348006853 ATP binding site [chemical binding]; other site 357348006854 Walker B motif; other site 357348006855 arginine finger; other site 357348006856 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 357348006857 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 357348006858 PAS domain; Region: PAS; smart00091 357348006859 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357348006860 dimer interface [polypeptide binding]; other site 357348006861 phosphorylation site [posttranslational modification] 357348006862 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357348006863 ATP binding site [chemical binding]; other site 357348006864 Mg2+ binding site [ion binding]; other site 357348006865 G-X-G motif; other site 357348006866 glutamine synthetase; Provisional; Region: glnA; PRK09469 357348006867 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 357348006868 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 357348006869 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 357348006870 active site residue [active] 357348006871 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 357348006872 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 357348006873 putative MPT binding site; other site 357348006874 Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264 357348006875 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 357348006876 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 357348006877 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 357348006878 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 357348006879 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 357348006880 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 357348006881 ATP binding site [chemical binding]; other site 357348006882 putative Mg++ binding site [ion binding]; other site 357348006883 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 357348006884 nucleotide binding region [chemical binding]; other site 357348006885 ATP-binding site [chemical binding]; other site 357348006886 Helicase associated domain (HA2); Region: HA2; pfam04408 357348006887 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 357348006888 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 357348006889 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 357348006890 N-acetylglutamate synthase; Validated; Region: PRK05279 357348006891 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 357348006892 putative feedback inhibition sensing region; other site 357348006893 putative nucleotide binding site [chemical binding]; other site 357348006894 putative substrate binding site [chemical binding]; other site 357348006895 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357348006896 Coenzyme A binding pocket [chemical binding]; other site 357348006897 oxidative damage protection protein; Provisional; Region: PRK05408 357348006898 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348006899 metabolite-proton symporter; Region: 2A0106; TIGR00883 357348006900 putative substrate translocation pore; other site 357348006901 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 357348006902 CoA-transferase family III; Region: CoA_transf_3; pfam02515 357348006903 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 357348006904 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 357348006905 active site 357348006906 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 357348006907 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348006908 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 357348006909 dimerization interface [polypeptide binding]; other site 357348006910 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 357348006911 HTH-like domain; Region: HTH_21; pfam13276 357348006912 Integrase core domain; Region: rve; pfam00665 357348006913 Integrase core domain; Region: rve_3; pfam13683 357348006914 Transposase; Region: HTH_Tnp_1; pfam01527 357348006915 putative aminotransferase; Validated; Region: PRK07480 357348006916 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 357348006917 inhibitor-cofactor binding pocket; inhibition site 357348006918 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348006919 catalytic residue [active] 357348006920 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 357348006921 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 357348006922 Peptidase C26; Region: Peptidase_C26; pfam07722 357348006923 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 357348006924 catalytic triad [active] 357348006925 N-formylglutamate amidohydrolase; Region: FGase; cl01522 357348006926 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 357348006927 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 357348006928 active site 357348006929 imidazolonepropionase; Validated; Region: PRK09356 357348006930 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 357348006931 active site 357348006932 HutD; Region: HutD; pfam05962 357348006933 urocanate hydratase; Provisional; Region: PRK05414 357348006934 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 357348006935 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 357348006936 DNA-binding site [nucleotide binding]; DNA binding site 357348006937 UTRA domain; Region: UTRA; pfam07702 357348006938 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 357348006939 active sites [active] 357348006940 tetramer interface [polypeptide binding]; other site 357348006941 Transposase domain (DUF772); Region: DUF772; pfam05598 357348006942 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 357348006943 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 357348006944 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 357348006945 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 357348006946 Autoinducer binding domain; Region: Autoind_bind; pfam03472 357348006947 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 357348006948 DNA binding residues [nucleotide binding] 357348006949 dimerization interface [polypeptide binding]; other site 357348006950 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 357348006951 ligand-binding site [chemical binding]; other site 357348006952 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 357348006953 DNA photolyase; Region: DNA_photolyase; pfam00875 357348006954 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 357348006955 Fatty acid desaturase; Region: FA_desaturase; pfam00487 357348006956 Di-iron ligands [ion binding]; other site 357348006957 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 357348006958 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 357348006959 NnrS protein; Region: NnrS; pfam05940 357348006960 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 357348006961 Class III ribonucleotide reductase; Region: RNR_III; cd01675 357348006962 effector binding site; other site 357348006963 active site 357348006964 Zn binding site [ion binding]; other site 357348006965 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 357348006966 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 357348006967 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 357348006968 FeS/SAM binding site; other site 357348006969 DGC domain; Region: DGC; pfam08859 357348006970 SCP-2 sterol transfer family; Region: SCP2; cl01225 357348006971 putative protease; Provisional; Region: PRK15447 357348006972 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 357348006973 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 357348006974 Peptidase family U32; Region: Peptidase_U32; pfam01136 357348006975 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 357348006976 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 357348006977 FMN binding site [chemical binding]; other site 357348006978 substrate binding site [chemical binding]; other site 357348006979 putative catalytic residue [active] 357348006980 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 357348006981 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 357348006982 ligand binding site [chemical binding]; other site 357348006983 flexible hinge region; other site 357348006984 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 357348006985 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 357348006986 HemN C-terminal domain; Region: HemN_C; pfam06969 357348006987 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 357348006988 dimerization interface [polypeptide binding]; other site 357348006989 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 357348006990 dimer interface [polypeptide binding]; other site 357348006991 putative CheW interface [polypeptide binding]; other site 357348006992 NnrS protein; Region: NnrS; pfam05940 357348006993 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 357348006994 putative ABC transporter; Region: ycf24; CHL00085 357348006995 FeS assembly ATPase SufC; Region: sufC; TIGR01978 357348006996 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 357348006997 Walker A/P-loop; other site 357348006998 ATP binding site [chemical binding]; other site 357348006999 Q-loop/lid; other site 357348007000 ABC transporter signature motif; other site 357348007001 Walker B; other site 357348007002 D-loop; other site 357348007003 H-loop/switch region; other site 357348007004 FeS assembly protein SufD; Region: sufD; TIGR01981 357348007005 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 357348007006 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 357348007007 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 357348007008 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 357348007009 catalytic residue [active] 357348007010 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 357348007011 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 357348007012 trimerization site [polypeptide binding]; other site 357348007013 active site 357348007014 Domain of unknown function DUF59; Region: DUF59; cl00941 357348007015 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 357348007016 Transcriptional regulator; Region: Rrf2; cl17282 357348007017 Rrf2 family protein; Region: rrf2_super; TIGR00738 357348007018 Hemerythrin; Region: Hemerythrin; cd12107 357348007019 Fe binding site [ion binding]; other site 357348007020 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 357348007021 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 357348007022 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 357348007023 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 357348007024 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 357348007025 D-pathway; other site 357348007026 Putative ubiquinol binding site [chemical binding]; other site 357348007027 Low-spin heme (heme b) binding site [chemical binding]; other site 357348007028 Putative water exit pathway; other site 357348007029 Binuclear center (heme o3/CuB) [ion binding]; other site 357348007030 K-pathway; other site 357348007031 Putative proton exit pathway; other site 357348007032 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 357348007033 Subunit I/III interface [polypeptide binding]; other site 357348007034 Subunit III/IV interface [polypeptide binding]; other site 357348007035 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 357348007036 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 357348007037 Fatty acid desaturase; Region: FA_desaturase; pfam00487 357348007038 putative di-iron ligands [ion binding]; other site 357348007039 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 357348007040 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 357348007041 substrate binding pocket [chemical binding]; other site 357348007042 membrane-bound complex binding site; other site 357348007043 hinge residues; other site 357348007044 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 357348007045 dimer interface [polypeptide binding]; other site 357348007046 N-terminal domain interface [polypeptide binding]; other site 357348007047 substrate binding pocket (H-site) [chemical binding]; other site 357348007048 succinylglutamate desuccinylase; Provisional; Region: PRK05324 357348007049 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 357348007050 active site 357348007051 Zn binding site [ion binding]; other site 357348007052 succinylarginine dihydrolase; Provisional; Region: PRK13281 357348007053 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 357348007054 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 357348007055 NAD(P) binding site [chemical binding]; other site 357348007056 catalytic residues [active] 357348007057 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 357348007058 arginine N-succinyltransferase; Region: arg_catab_AstA; TIGR03244 357348007059 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 357348007060 arginine/ornithine succinyltransferase, alpha subunit; Region: arg_AOST_alph; TIGR03245 357348007061 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 357348007062 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 357348007063 inhibitor-cofactor binding pocket; inhibition site 357348007064 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348007065 catalytic residue [active] 357348007066 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 357348007067 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 357348007068 conserved cys residue [active] 357348007069 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357348007070 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357348007071 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 357348007072 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 357348007073 Walker A/P-loop; other site 357348007074 ATP binding site [chemical binding]; other site 357348007075 Q-loop/lid; other site 357348007076 ABC transporter signature motif; other site 357348007077 Walker B; other site 357348007078 D-loop; other site 357348007079 H-loop/switch region; other site 357348007080 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 357348007081 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348007082 dimer interface [polypeptide binding]; other site 357348007083 conserved gate region; other site 357348007084 putative PBP binding loops; other site 357348007085 ABC-ATPase subunit interface; other site 357348007086 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 357348007087 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348007088 dimer interface [polypeptide binding]; other site 357348007089 conserved gate region; other site 357348007090 putative PBP binding loops; other site 357348007091 ABC-ATPase subunit interface; other site 357348007092 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 357348007093 putative membrane protein; Region: HpnL; TIGR03476 357348007094 hopanoid biosynthesis associated protein HpnK and similar proteins; Region: YdjC_HpnK_like; cd10804 357348007095 putative active site [active] 357348007096 YdjC motif; other site 357348007097 Mg binding site [ion binding]; other site 357348007098 putative homodimer interface [polypeptide binding]; other site 357348007099 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 357348007100 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 357348007101 B12 binding site [chemical binding]; other site 357348007102 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 357348007103 FeS/SAM binding site; other site 357348007104 hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472 357348007105 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 357348007106 ligand binding site; other site 357348007107 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 357348007108 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 357348007109 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 357348007110 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 357348007111 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 357348007112 pyridoxamine kinase; Validated; Region: PRK05756 357348007113 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 357348007114 dimer interface [polypeptide binding]; other site 357348007115 pyridoxal binding site [chemical binding]; other site 357348007116 ATP binding site [chemical binding]; other site 357348007117 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 357348007118 Phosphoesterase family; Region: Phosphoesterase; pfam04185 357348007119 Domain of unknown function (DUF756); Region: DUF756; pfam05506 357348007120 Domain of unknown function (DUF756); Region: DUF756; pfam05506 357348007121 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 357348007122 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 357348007123 dimerization interface [polypeptide binding]; other site 357348007124 ligand binding site [chemical binding]; other site 357348007125 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 357348007126 Predicted membrane protein (DUF2214); Region: DUF2214; pfam09980 357348007127 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 357348007128 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357348007129 putative ADP-binding pocket [chemical binding]; other site 357348007130 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 357348007131 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 357348007132 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 357348007133 Walker A/P-loop; other site 357348007134 ATP binding site [chemical binding]; other site 357348007135 Q-loop/lid; other site 357348007136 ABC transporter signature motif; other site 357348007137 Walker B; other site 357348007138 D-loop; other site 357348007139 H-loop/switch region; other site 357348007140 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 357348007141 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 357348007142 active site 357348007143 homotetramer interface [polypeptide binding]; other site 357348007144 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 357348007145 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 357348007146 active site 357348007147 motif I; other site 357348007148 motif II; other site 357348007149 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 357348007150 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 357348007151 Cu(I) binding site [ion binding]; other site 357348007152 Protein of unknown function (DUF461); Region: DUF461; pfam04314 357348007153 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 357348007154 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 357348007155 Pirin-related protein [General function prediction only]; Region: COG1741 357348007156 Pirin; Region: Pirin; pfam02678 357348007157 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 357348007158 LysR family transcriptional regulator; Provisional; Region: PRK14997 357348007159 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348007160 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 357348007161 putative effector binding pocket; other site 357348007162 putative dimerization interface [polypeptide binding]; other site 357348007163 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 357348007164 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 357348007165 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 357348007166 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 357348007167 GIY-YIG motif/motif A; other site 357348007168 active site 357348007169 catalytic site [active] 357348007170 putative DNA binding site [nucleotide binding]; other site 357348007171 metal binding site [ion binding]; metal-binding site 357348007172 UvrB/uvrC motif; Region: UVR; pfam02151 357348007173 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 357348007174 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 357348007175 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 357348007176 Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093 357348007177 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394 357348007178 elongation factor P; Validated; Region: PRK00529 357348007179 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 357348007180 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 357348007181 RNA binding site [nucleotide binding]; other site 357348007182 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 357348007183 RNA binding site [nucleotide binding]; other site 357348007184 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 357348007185 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348007186 active site 357348007187 phosphorylation site [posttranslational modification] 357348007188 intermolecular recognition site; other site 357348007189 dimerization interface [polypeptide binding]; other site 357348007190 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357348007191 Walker A motif; other site 357348007192 ATP binding site [chemical binding]; other site 357348007193 Walker B motif; other site 357348007194 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 357348007195 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 357348007196 beta-hexosaminidase; Provisional; Region: PRK05337 357348007197 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 357348007198 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 357348007199 active site 357348007200 hydrophilic channel; other site 357348007201 dimerization interface [polypeptide binding]; other site 357348007202 catalytic residues [active] 357348007203 active site lid [active] 357348007204 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 357348007205 Recombination protein O N terminal; Region: RecO_N; pfam11967 357348007206 Recombination protein O C terminal; Region: RecO_C; pfam02565 357348007207 GTPase Era; Reviewed; Region: era; PRK00089 357348007208 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 357348007209 G1 box; other site 357348007210 GTP/Mg2+ binding site [chemical binding]; other site 357348007211 Switch I region; other site 357348007212 G2 box; other site 357348007213 Switch II region; other site 357348007214 G3 box; other site 357348007215 G4 box; other site 357348007216 G5 box; other site 357348007217 KH domain; Region: KH_2; pfam07650 357348007218 ribonuclease III; Provisional; Region: PRK14718 357348007219 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 357348007220 dimerization interface [polypeptide binding]; other site 357348007221 active site 357348007222 metal binding site [ion binding]; metal-binding site 357348007223 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 357348007224 signal peptidase I; Provisional; Region: PRK10861 357348007225 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 357348007226 Catalytic site [active] 357348007227 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 357348007228 GTP-binding protein LepA; Provisional; Region: PRK05433 357348007229 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 357348007230 G1 box; other site 357348007231 putative GEF interaction site [polypeptide binding]; other site 357348007232 GTP/Mg2+ binding site [chemical binding]; other site 357348007233 Switch I region; other site 357348007234 G2 box; other site 357348007235 G3 box; other site 357348007236 Switch II region; other site 357348007237 G4 box; other site 357348007238 G5 box; other site 357348007239 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 357348007240 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 357348007241 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 357348007242 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 357348007243 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 357348007244 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 357348007245 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 357348007246 protein binding site [polypeptide binding]; other site 357348007247 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 357348007248 protein binding site [polypeptide binding]; other site 357348007249 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 357348007250 anti-sigma E factor; Provisional; Region: rseB; PRK09455 357348007251 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 357348007252 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 357348007253 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 357348007254 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 357348007255 DNA binding residues [nucleotide binding] 357348007256 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 357348007257 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 357348007258 dimer interface [polypeptide binding]; other site 357348007259 active site 357348007260 acyl carrier protein; Provisional; Region: acpP; PRK00982 357348007261 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 357348007262 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 357348007263 NAD(P) binding site [chemical binding]; other site 357348007264 homotetramer interface [polypeptide binding]; other site 357348007265 homodimer interface [polypeptide binding]; other site 357348007266 active site 357348007267 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 357348007268 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 357348007269 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 357348007270 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 357348007271 dimer interface [polypeptide binding]; other site 357348007272 active site 357348007273 CoA binding pocket [chemical binding]; other site 357348007274 putative phosphate acyltransferase; Provisional; Region: PRK05331 357348007275 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 357348007276 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 357348007277 Maf-like protein; Region: Maf; pfam02545 357348007278 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 357348007279 active site 357348007280 dimer interface [polypeptide binding]; other site 357348007281 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 357348007282 putative SAM binding site [chemical binding]; other site 357348007283 homodimer interface [polypeptide binding]; other site 357348007284 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 357348007285 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 357348007286 tandem repeat interface [polypeptide binding]; other site 357348007287 oligomer interface [polypeptide binding]; other site 357348007288 active site residues [active] 357348007289 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 357348007290 iron-sulfur cluster [ion binding]; other site 357348007291 [2Fe-2S] cluster binding site [ion binding]; other site 357348007292 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 357348007293 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 357348007294 motif II; other site 357348007295 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 357348007296 S4 domain; Region: S4; pfam01479 357348007297 RNA binding surface [nucleotide binding]; other site 357348007298 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 357348007299 active site 357348007300 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 357348007301 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 357348007302 homodimer interface [polypeptide binding]; other site 357348007303 oligonucleotide binding site [chemical binding]; other site 357348007304 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 357348007305 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 357348007306 FeS/SAM binding site; other site 357348007307 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 357348007308 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 357348007309 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 357348007310 GTP binding site; other site 357348007311 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 357348007312 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 357348007313 dimer interface [polypeptide binding]; other site 357348007314 putative functional site; other site 357348007315 putative MPT binding site; other site 357348007316 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 357348007317 RmuC family; Region: RmuC; pfam02646 357348007318 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 357348007319 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 357348007320 dimerization interface [polypeptide binding]; other site 357348007321 ligand binding site [chemical binding]; other site 357348007322 NADP binding site [chemical binding]; other site 357348007323 catalytic site [active] 357348007324 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 357348007325 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 357348007326 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 357348007327 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 357348007328 active site 357348007329 Ferredoxin [Energy production and conversion]; Region: COG1146 357348007330 4Fe-4S binding domain; Region: Fer4; cl02805 357348007331 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 357348007332 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 357348007333 CreA protein; Region: CreA; pfam05981 357348007334 Protein of unknown function (DUF4088); Region: DUF4088; pfam13317 357348007335 S4 domain; Region: S4_2; pfam13275 357348007336 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 357348007337 multidrug efflux protein; Reviewed; Region: PRK01766 357348007338 cation binding site [ion binding]; other site 357348007339 fumarate hydratase; Reviewed; Region: fumC; PRK00485 357348007340 Class II fumarases; Region: Fumarase_classII; cd01362 357348007341 active site 357348007342 tetramer interface [polypeptide binding]; other site 357348007343 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 357348007344 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 357348007345 dimerization interface [polypeptide binding]; other site 357348007346 putative DNA binding site [nucleotide binding]; other site 357348007347 putative Zn2+ binding site [ion binding]; other site 357348007348 FecR protein; Region: FecR; pfam04773 357348007349 thymidylate synthase; Provisional; Region: thyA; PRK13821 357348007350 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 357348007351 dimerization interface [polypeptide binding]; other site 357348007352 active site 357348007353 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 357348007354 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357348007355 Walker A motif; other site 357348007356 ATP binding site [chemical binding]; other site 357348007357 Walker B motif; other site 357348007358 arginine finger; other site 357348007359 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 357348007360 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 357348007361 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357348007362 Walker A motif; other site 357348007363 ATP binding site [chemical binding]; other site 357348007364 Walker B motif; other site 357348007365 arginine finger; other site 357348007366 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 357348007367 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 357348007368 folate binding site [chemical binding]; other site 357348007369 NADP+ binding site [chemical binding]; other site 357348007370 Transposase domain (DUF772); Region: DUF772; pfam05598 357348007371 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 357348007372 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 357348007373 peptidase PmbA; Provisional; Region: PRK11040 357348007374 hypothetical protein; Provisional; Region: PRK05255 357348007375 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 357348007376 MPT binding site; other site 357348007377 trimer interface [polypeptide binding]; other site 357348007378 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 357348007379 catalytic site [active] 357348007380 putative active site [active] 357348007381 putative substrate binding site [chemical binding]; other site 357348007382 dimer interface [polypeptide binding]; other site 357348007383 Peptidase family M48; Region: Peptidase_M48; pfam01435 357348007384 GTPase RsgA; Reviewed; Region: PRK00098 357348007385 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 357348007386 RNA binding site [nucleotide binding]; other site 357348007387 homodimer interface [polypeptide binding]; other site 357348007388 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 357348007389 GTPase/Zn-binding domain interface [polypeptide binding]; other site 357348007390 GTP/Mg2+ binding site [chemical binding]; other site 357348007391 G4 box; other site 357348007392 G5 box; other site 357348007393 G1 box; other site 357348007394 Switch I region; other site 357348007395 G2 box; other site 357348007396 G3 box; other site 357348007397 Switch II region; other site 357348007398 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 357348007399 CobD/CbiB family protein; Provisional; Region: PRK07630 357348007400 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 357348007401 putative active site [active] 357348007402 putative CoA binding site [chemical binding]; other site 357348007403 nudix motif; other site 357348007404 metal binding site [ion binding]; metal-binding site 357348007405 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 357348007406 Coenzyme A binding pocket [chemical binding]; other site 357348007407 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 357348007408 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 357348007409 16S rRNA processing protein RimM; Region: 16S_RimM; TIGR02273 357348007410 RimM N-terminal domain; Region: RimM; pfam01782 357348007411 PRC-barrel domain; Region: PRC; pfam05239 357348007412 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 357348007413 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 357348007414 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 357348007415 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 357348007416 FeS/SAM binding site; other site 357348007417 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 357348007418 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 357348007419 AsnC family; Region: AsnC_trans_reg; pfam01037 357348007420 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 357348007421 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 357348007422 hydroxyglutarate oxidase; Provisional; Region: PRK11728 357348007423 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 357348007424 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 357348007425 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 357348007426 active site 357348007427 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 357348007428 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 357348007429 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 357348007430 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 357348007431 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 357348007432 Ligand binding site [chemical binding]; other site 357348007433 Electron transfer flavoprotein domain; Region: ETF; pfam01012 357348007434 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 357348007435 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 357348007436 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348007437 dimer interface [polypeptide binding]; other site 357348007438 conserved gate region; other site 357348007439 ABC-ATPase subunit interface; other site 357348007440 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 357348007441 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 357348007442 Walker A/P-loop; other site 357348007443 ATP binding site [chemical binding]; other site 357348007444 Q-loop/lid; other site 357348007445 ABC transporter signature motif; other site 357348007446 Walker B; other site 357348007447 D-loop; other site 357348007448 H-loop/switch region; other site 357348007449 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 357348007450 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 357348007451 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 357348007452 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 357348007453 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 357348007454 putative active site [active] 357348007455 Zn binding site [ion binding]; other site 357348007456 Transglycosylase SLT domain; Region: SLT_2; pfam13406 357348007457 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 357348007458 N-acetyl-D-glucosamine binding site [chemical binding]; other site 357348007459 catalytic residue [active] 357348007460 cysteine synthase B; Region: cysM; TIGR01138 357348007461 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 357348007462 dimer interface [polypeptide binding]; other site 357348007463 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348007464 catalytic residue [active] 357348007465 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 357348007466 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 357348007467 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 357348007468 NADP binding site [chemical binding]; other site 357348007469 homopentamer interface [polypeptide binding]; other site 357348007470 substrate binding site [chemical binding]; other site 357348007471 active site 357348007472 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 357348007473 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 357348007474 putative ribose interaction site [chemical binding]; other site 357348007475 putative ADP binding site [chemical binding]; other site 357348007476 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 357348007477 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 357348007478 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 357348007479 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 357348007480 tetratricopeptide repeat protein; Provisional; Region: PRK11788 357348007481 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357348007482 binding surface 357348007483 TPR motif; other site 357348007484 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 357348007485 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 357348007486 IHF dimer interface [polypeptide binding]; other site 357348007487 IHF - DNA interface [nucleotide binding]; other site 357348007488 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 357348007489 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 357348007490 RNA binding site [nucleotide binding]; other site 357348007491 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 357348007492 RNA binding site [nucleotide binding]; other site 357348007493 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 357348007494 RNA binding site [nucleotide binding]; other site 357348007495 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 357348007496 RNA binding site [nucleotide binding]; other site 357348007497 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 357348007498 RNA binding site [nucleotide binding]; other site 357348007499 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 357348007500 RNA binding site [nucleotide binding]; other site 357348007501 cytidylate kinase; Provisional; Region: cmk; PRK00023 357348007502 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 357348007503 CMP-binding site; other site 357348007504 The sites determining sugar specificity; other site 357348007505 bifunctional prephenate dehydrogenase/3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK11861 357348007506 prephenate dehydrogenase; Validated; Region: PRK08507 357348007507 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 357348007508 hinge; other site 357348007509 active site 357348007510 Chorismate mutase type II; Region: CM_2; smart00830 357348007511 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 357348007512 Prephenate dehydratase; Region: PDT; pfam00800 357348007513 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 357348007514 putative L-Phe binding site [chemical binding]; other site 357348007515 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 357348007516 homodimer interface [polypeptide binding]; other site 357348007517 substrate-cofactor binding pocket; other site 357348007518 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348007519 catalytic residue [active] 357348007520 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 357348007521 DNA gyrase subunit A; Validated; Region: PRK05560 357348007522 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 357348007523 CAP-like domain; other site 357348007524 active site 357348007525 primary dimer interface [polypeptide binding]; other site 357348007526 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 357348007527 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 357348007528 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 357348007529 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 357348007530 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 357348007531 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 357348007532 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 357348007533 ligand binding site [chemical binding]; other site 357348007534 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 357348007535 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357348007536 S-adenosylmethionine binding site [chemical binding]; other site 357348007537 phosphoglycolate phosphatase; Provisional; Region: PRK13226 357348007538 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 357348007539 motif II; other site 357348007540 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357348007541 S-adenosylmethionine binding site [chemical binding]; other site 357348007542 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 357348007543 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 357348007544 PBP superfamily domain; Region: PBP_like; pfam12727 357348007545 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 357348007546 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081 357348007547 putative dimer interface [polypeptide binding]; other site 357348007548 [2Fe-2S] cluster binding site [ion binding]; other site 357348007549 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 357348007550 putative dimer interface [polypeptide binding]; other site 357348007551 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 357348007552 SLBB domain; Region: SLBB; pfam10531 357348007553 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 357348007554 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 357348007555 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 357348007556 catalytic loop [active] 357348007557 iron binding site [ion binding]; other site 357348007558 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929 357348007559 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 357348007560 [4Fe-4S] binding site [ion binding]; other site 357348007561 molybdopterin cofactor binding site; other site 357348007562 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 357348007563 molybdopterin cofactor binding site; other site 357348007564 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 357348007565 hypothetical protein; Provisional; Region: PRK06184 357348007566 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 357348007567 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357348007568 binding surface 357348007569 TPR motif; other site 357348007570 TPR repeat; Region: TPR_11; pfam13414 357348007571 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357348007572 binding surface 357348007573 TPR motif; other site 357348007574 TPR repeat; Region: TPR_11; pfam13414 357348007575 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357348007576 TPR repeat; Region: TPR_11; pfam13414 357348007577 TPR motif; other site 357348007578 binding surface 357348007579 TPR repeat; Region: TPR_11; pfam13414 357348007580 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357348007581 binding surface 357348007582 TPR motif; other site 357348007583 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 357348007584 citrate-proton symporter; Provisional; Region: PRK15075 357348007585 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348007586 putative substrate translocation pore; other site 357348007587 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 357348007588 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 357348007589 catalytic triad [active] 357348007590 amidase; Provisional; Region: PRK07056 357348007591 Amidase; Region: Amidase; cl11426 357348007592 disulfide bond formation protein B; Provisional; Region: PRK02110 357348007593 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 357348007594 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 357348007595 XdhC Rossmann domain; Region: XdhC_C; pfam13478 357348007596 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 357348007597 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 357348007598 active site 357348007599 purine riboside binding site [chemical binding]; other site 357348007600 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 357348007601 guanine deaminase; Provisional; Region: PRK09228 357348007602 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 357348007603 active site 357348007604 Predicted membrane protein [Function unknown]; Region: COG2119 357348007605 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 357348007606 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 357348007607 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 357348007608 aminopeptidase N; Provisional; Region: pepN; PRK14015 357348007609 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 357348007610 active site 357348007611 Zn binding site [ion binding]; other site 357348007612 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 357348007613 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 357348007614 THF binding site; other site 357348007615 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 357348007616 substrate binding site [chemical binding]; other site 357348007617 THF binding site; other site 357348007618 zinc-binding site [ion binding]; other site 357348007619 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 357348007620 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348007621 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 357348007622 putative dimerization interface [polypeptide binding]; other site 357348007623 fructose-1,6-bisphosphatase family protein; Region: PLN02628 357348007624 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 357348007625 AMP binding site [chemical binding]; other site 357348007626 metal binding site [ion binding]; metal-binding site 357348007627 active site 357348007628 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 357348007629 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 357348007630 catalytic residues [active] 357348007631 BNR repeat-like domain; Region: BNR_2; pfam13088 357348007632 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 357348007633 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 357348007634 N-terminal plug; other site 357348007635 ligand-binding site [chemical binding]; other site 357348007636 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 357348007637 chorismate mutase; Provisional; Region: PRK09269 357348007638 Chorismate mutase type II; Region: CM_2; cl00693 357348007639 Allexivirus 40kDa protein; Region: Allexi_40kDa; pfam05549 357348007640 exonuclease, DNA polymerase III, epsilon subunit family; Region: dnaq; TIGR00573 357348007641 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 357348007642 active site 357348007643 catalytic site [active] 357348007644 substrate binding site [chemical binding]; other site 357348007645 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 357348007646 GIY-YIG motif/motif A; other site 357348007647 active site 357348007648 catalytic site [active] 357348007649 putative DNA binding site [nucleotide binding]; other site 357348007650 metal binding site [ion binding]; metal-binding site 357348007651 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 357348007652 DNA-binding site [nucleotide binding]; DNA binding site 357348007653 RNA-binding motif; other site 357348007654 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 357348007655 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 357348007656 trimer interface [polypeptide binding]; other site 357348007657 eyelet of channel; other site 357348007658 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 357348007659 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 357348007660 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 357348007661 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 357348007662 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 357348007663 Zn2+ binding site [ion binding]; other site 357348007664 Mg2+ binding site [ion binding]; other site 357348007665 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 357348007666 synthetase active site [active] 357348007667 NTP binding site [chemical binding]; other site 357348007668 metal binding site [ion binding]; metal-binding site 357348007669 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 357348007670 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 357348007671 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 357348007672 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 357348007673 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 357348007674 catalytic site [active] 357348007675 G-X2-G-X-G-K; other site 357348007676 hypothetical protein; Provisional; Region: PRK11820 357348007677 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 357348007678 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 357348007679 ribonuclease PH; Reviewed; Region: rph; PRK00173 357348007680 Ribonuclease PH; Region: RNase_PH_bact; cd11362 357348007681 hexamer interface [polypeptide binding]; other site 357348007682 active site 357348007683 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 357348007684 active site 357348007685 dimerization interface [polypeptide binding]; other site 357348007686 coproporphyrinogen III oxidase; Provisional; Region: PRK08898 357348007687 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 357348007688 FeS/SAM binding site; other site 357348007689 HemN C-terminal domain; Region: HemN_C; pfam06969 357348007690 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 357348007691 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 357348007692 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 357348007693 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348007694 metabolite-proton symporter; Region: 2A0106; TIGR00883 357348007695 putative substrate translocation pore; other site 357348007696 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 357348007697 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 357348007698 putative active site [active] 357348007699 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 357348007700 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 357348007701 putative ion selectivity filter; other site 357348007702 putative pore gating glutamate residue; other site 357348007703 putative H+/Cl- coupling transport residue; other site 357348007704 cell division topological specificity factor MinE; Provisional; Region: PRK13989 357348007705 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 357348007706 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 357348007707 Switch I; other site 357348007708 Switch II; other site 357348007709 septum formation inhibitor; Reviewed; Region: PRK01973 357348007710 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 357348007711 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 357348007712 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357348007713 Coenzyme A binding pocket [chemical binding]; other site 357348007714 seryl-tRNA synthetase; Provisional; Region: PRK05431 357348007715 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 357348007716 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 357348007717 dimer interface [polypeptide binding]; other site 357348007718 active site 357348007719 motif 1; other site 357348007720 motif 2; other site 357348007721 motif 3; other site 357348007722 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 357348007723 recombination factor protein RarA; Reviewed; Region: PRK13342 357348007724 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357348007725 Walker A motif; other site 357348007726 ATP binding site [chemical binding]; other site 357348007727 Walker B motif; other site 357348007728 arginine finger; other site 357348007729 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 357348007730 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 357348007731 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 357348007732 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 357348007733 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 357348007734 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 357348007735 thioredoxin reductase; Provisional; Region: PRK10262 357348007736 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 357348007737 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 357348007738 Smr domain; Region: Smr; pfam01713 357348007739 Predicted membrane protein [Function unknown]; Region: COG2860 357348007740 UPF0126 domain; Region: UPF0126; pfam03458 357348007741 UPF0126 domain; Region: UPF0126; pfam03458 357348007742 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 357348007743 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 357348007744 Walker A/P-loop; other site 357348007745 ATP binding site [chemical binding]; other site 357348007746 Q-loop/lid; other site 357348007747 ABC transporter signature motif; other site 357348007748 Walker B; other site 357348007749 D-loop; other site 357348007750 H-loop/switch region; other site 357348007751 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 357348007752 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348007753 dimer interface [polypeptide binding]; other site 357348007754 conserved gate region; other site 357348007755 putative PBP binding loops; other site 357348007756 ABC-ATPase subunit interface; other site 357348007757 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348007758 dimer interface [polypeptide binding]; other site 357348007759 conserved gate region; other site 357348007760 putative PBP binding loops; other site 357348007761 ABC-ATPase subunit interface; other site 357348007762 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 357348007763 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 357348007764 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 357348007765 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 357348007766 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 357348007767 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 357348007768 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 357348007769 putative active site [active] 357348007770 bifunctional glucokinase/RpiR family transcriptional regulator; Provisional; Region: PRK14101 357348007771 glucokinase; Provisional; Region: glk; PRK00292 357348007772 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 357348007773 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 357348007774 putative active site [active] 357348007775 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 357348007776 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 357348007777 substrate binding pocket [chemical binding]; other site 357348007778 membrane-bound complex binding site; other site 357348007779 hinge residues; other site 357348007780 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 357348007781 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348007782 dimer interface [polypeptide binding]; other site 357348007783 conserved gate region; other site 357348007784 putative PBP binding loops; other site 357348007785 ABC-ATPase subunit interface; other site 357348007786 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 357348007787 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 357348007788 Walker A/P-loop; other site 357348007789 ATP binding site [chemical binding]; other site 357348007790 Q-loop/lid; other site 357348007791 ABC transporter signature motif; other site 357348007792 Walker B; other site 357348007793 D-loop; other site 357348007794 H-loop/switch region; other site 357348007795 D-cysteine desulfhydrase; Validated; Region: PRK03910 357348007796 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 357348007797 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 357348007798 catalytic residue [active] 357348007799 Protein of unknown function (DUF3088); Region: DUF3088; pfam11287 357348007800 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348007801 putative substrate translocation pore; other site 357348007802 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 357348007803 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 357348007804 inhibitor-cofactor binding pocket; inhibition site 357348007805 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348007806 catalytic residue [active] 357348007807 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 357348007808 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 357348007809 catalytic motif [active] 357348007810 Zn binding site [ion binding]; other site 357348007811 RibD C-terminal domain; Region: RibD_C; cl17279 357348007812 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 357348007813 Lumazine binding domain; Region: Lum_binding; pfam00677 357348007814 Lumazine binding domain; Region: Lum_binding; pfam00677 357348007815 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 357348007816 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 357348007817 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 357348007818 dimerization interface [polypeptide binding]; other site 357348007819 active site 357348007820 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 357348007821 homopentamer interface [polypeptide binding]; other site 357348007822 active site 357348007823 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 357348007824 putative RNA binding site [nucleotide binding]; other site 357348007825 aminotransferase; Validated; Region: PRK07337 357348007826 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 357348007827 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348007828 homodimer interface [polypeptide binding]; other site 357348007829 catalytic residue [active] 357348007830 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 357348007831 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 357348007832 N-acetyl-D-glucosamine binding site [chemical binding]; other site 357348007833 catalytic residue [active] 357348007834 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 357348007835 LysE type translocator; Region: LysE; cl00565 357348007836 serine racemase; Region: PLN02970 357348007837 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 357348007838 tetramer interface [polypeptide binding]; other site 357348007839 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348007840 catalytic residue [active] 357348007841 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 357348007842 Rossmann-like domain; Region: Rossmann-like; pfam10727 357348007843 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 357348007844 YGGT family; Region: YGGT; pfam02325 357348007845 YGGT family; Region: YGGT; pfam02325 357348007846 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 357348007847 chromosome condensation membrane protein; Provisional; Region: PRK14196 357348007848 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 357348007849 active site 357348007850 catalytic triad [active] 357348007851 calcium binding site [ion binding]; other site 357348007852 Methyltransferase domain; Region: Methyltransf_31; pfam13847 357348007853 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357348007854 S-adenosylmethionine binding site [chemical binding]; other site 357348007855 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 357348007856 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357348007857 S-adenosylmethionine binding site [chemical binding]; other site 357348007858 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 357348007859 Protein of unknown function (DUF1439); Region: DUF1439; cl06345 357348007860 Flagellin N-methylase; Region: FliB; pfam03692 357348007861 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 357348007862 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 357348007863 FeS/SAM binding site; other site 357348007864 HemN C-terminal domain; Region: HemN_C; pfam06969 357348007865 Transposase domain (DUF772); Region: DUF772; pfam05598 357348007866 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 357348007867 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 357348007868 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 357348007869 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357348007870 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 357348007871 active site residue [active] 357348007872 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 357348007873 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 357348007874 inhibitor-cofactor binding pocket; inhibition site 357348007875 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348007876 catalytic residue [active] 357348007877 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 357348007878 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 357348007879 putative ligand binding site [chemical binding]; other site 357348007880 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 357348007881 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 357348007882 TM-ABC transporter signature motif; other site 357348007883 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 357348007884 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 357348007885 TM-ABC transporter signature motif; other site 357348007886 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 357348007887 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 357348007888 Walker A/P-loop; other site 357348007889 ATP binding site [chemical binding]; other site 357348007890 Q-loop/lid; other site 357348007891 ABC transporter signature motif; other site 357348007892 Walker B; other site 357348007893 D-loop; other site 357348007894 H-loop/switch region; other site 357348007895 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 357348007896 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 357348007897 Walker A/P-loop; other site 357348007898 ATP binding site [chemical binding]; other site 357348007899 Q-loop/lid; other site 357348007900 ABC transporter signature motif; other site 357348007901 Walker B; other site 357348007902 D-loop; other site 357348007903 H-loop/switch region; other site 357348007904 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 357348007905 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 357348007906 alpha-gamma subunit interface [polypeptide binding]; other site 357348007907 beta-gamma subunit interface [polypeptide binding]; other site 357348007908 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 357348007909 gamma-beta subunit interface [polypeptide binding]; other site 357348007910 alpha-beta subunit interface [polypeptide binding]; other site 357348007911 urease subunit alpha; Reviewed; Region: ureC; PRK13207 357348007912 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 357348007913 subunit interactions [polypeptide binding]; other site 357348007914 active site 357348007915 flap region; other site 357348007916 urease accessory protein UreE; Provisional; Region: ureE; PRK13263 357348007917 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 357348007918 dimer interface [polypeptide binding]; other site 357348007919 catalytic residues [active] 357348007920 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 357348007921 UreF; Region: UreF; pfam01730 357348007922 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 357348007923 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 357348007924 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 357348007925 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 357348007926 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase; Region: Kdo_hydroxy; pfam11004 357348007927 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 357348007928 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 357348007929 putative active site [active] 357348007930 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 357348007931 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 357348007932 active site 357348007933 substrate binding site [chemical binding]; other site 357348007934 metal binding site [ion binding]; metal-binding site 357348007935 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 357348007936 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 357348007937 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 357348007938 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 357348007939 active site 357348007940 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 357348007941 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357348007942 putative ADP-binding pocket [chemical binding]; other site 357348007943 UDP-glucose 4-epimerase; Region: PLN02240 357348007944 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 357348007945 NAD binding site [chemical binding]; other site 357348007946 homodimer interface [polypeptide binding]; other site 357348007947 active site 357348007948 substrate binding site [chemical binding]; other site 357348007949 This subfamily is composed of uncharacterized bacterial glycosyltransferases in the MraY-like family. This family contains both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases, which...; Region: GT_MraY_like; cd06912 357348007950 Mg++ binding site [ion binding]; other site 357348007951 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 357348007952 putative catalytic motif [active] 357348007953 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 357348007954 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 357348007955 NAD(P) binding site [chemical binding]; other site 357348007956 homodimer interface [polypeptide binding]; other site 357348007957 substrate binding site [chemical binding]; other site 357348007958 active site 357348007959 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 357348007960 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 357348007961 Mg++ binding site [ion binding]; other site 357348007962 putative catalytic motif [active] 357348007963 putative substrate binding site [chemical binding]; other site 357348007964 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 357348007965 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 357348007966 putative NAD(P) binding site [chemical binding]; other site 357348007967 active site 357348007968 putative substrate binding site [chemical binding]; other site 357348007969 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 357348007970 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 357348007971 active site 357348007972 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 357348007973 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 357348007974 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 357348007975 Probable Catalytic site; other site 357348007976 metal-binding site 357348007977 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 357348007978 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 357348007979 active site 357348007980 Methyltransferase domain; Region: Methyltransf_23; pfam13489 357348007981 Methyltransferase domain; Region: Methyltransf_12; pfam08242 357348007982 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 357348007983 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 357348007984 active site 357348007985 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 357348007986 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 357348007987 Probable Catalytic site; other site 357348007988 metal-binding site 357348007989 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 357348007990 extended (e) SDRs; Region: SDR_e; cd08946 357348007991 NAD(P) binding site [chemical binding]; other site 357348007992 active site 357348007993 substrate binding site [chemical binding]; other site 357348007994 Acyltransferase family; Region: Acyl_transf_3; pfam01757 357348007995 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 357348007996 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 357348007997 Walker A/P-loop; other site 357348007998 ATP binding site [chemical binding]; other site 357348007999 Q-loop/lid; other site 357348008000 ABC transporter signature motif; other site 357348008001 Walker B; other site 357348008002 D-loop; other site 357348008003 H-loop/switch region; other site 357348008004 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 357348008005 putative carbohydrate binding site [chemical binding]; other site 357348008006 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 357348008007 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 357348008008 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 357348008009 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 357348008010 NADP binding site [chemical binding]; other site 357348008011 active site 357348008012 putative substrate binding site [chemical binding]; other site 357348008013 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 357348008014 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 357348008015 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 357348008016 substrate binding site; other site 357348008017 tetramer interface; other site 357348008018 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 357348008019 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 357348008020 NAD binding site [chemical binding]; other site 357348008021 substrate binding site [chemical binding]; other site 357348008022 homodimer interface [polypeptide binding]; other site 357348008023 active site 357348008024 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 357348008025 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 357348008026 active site 357348008027 metal binding site [ion binding]; metal-binding site 357348008028 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 357348008029 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 357348008030 putative acyl-acceptor binding pocket; other site 357348008031 dihydroorotase; Provisional; Region: PRK07627 357348008032 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 357348008033 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 357348008034 active site 357348008035 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 357348008036 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 357348008037 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 357348008038 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 357348008039 active site 357348008040 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 357348008041 hypothetical protein; Validated; Region: PRK00228 357348008042 Rubredoxin [Energy production and conversion]; Region: COG1773 357348008043 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 357348008044 iron binding site [ion binding]; other site 357348008045 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 357348008046 dimer interface [polypeptide binding]; other site 357348008047 substrate binding site [chemical binding]; other site 357348008048 ATP binding site [chemical binding]; other site 357348008049 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 357348008050 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 357348008051 ring oligomerisation interface [polypeptide binding]; other site 357348008052 ATP/Mg binding site [chemical binding]; other site 357348008053 stacking interactions; other site 357348008054 hinge regions; other site 357348008055 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 357348008056 oligomerisation interface [polypeptide binding]; other site 357348008057 mobile loop; other site 357348008058 roof hairpin; other site 357348008059 Predicted transcriptional regulators [Transcription]; Region: COG1733 357348008060 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 357348008061 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 357348008062 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 357348008063 putative NAD(P) binding site [chemical binding]; other site 357348008064 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 357348008065 Protein of unknown function (DUF2957); Region: DUF2957; pfam11170 357348008066 Protein of unknown function (DUF2957); Region: DUF2957; pfam11170 357348008067 Predicted transcriptional regulators [Transcription]; Region: COG1733 357348008068 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 357348008069 dimerization interface [polypeptide binding]; other site 357348008070 putative DNA binding site [nucleotide binding]; other site 357348008071 putative Zn2+ binding site [ion binding]; other site 357348008072 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 357348008073 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 357348008074 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 357348008075 non-specific DNA binding site [nucleotide binding]; other site 357348008076 salt bridge; other site 357348008077 sequence-specific DNA binding site [nucleotide binding]; other site 357348008078 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 357348008079 Coenzyme A binding pocket [chemical binding]; other site 357348008080 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 357348008081 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 357348008082 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 357348008083 putative active site [active] 357348008084 catalytic site [active] 357348008085 putative metal binding site [ion binding]; other site 357348008086 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 357348008087 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348008088 putative substrate translocation pore; other site 357348008089 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 357348008090 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 357348008091 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 357348008092 3HB-oligomer hydrolase (3HBOH); Region: 3HBOH; pfam10605 357348008093 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 357348008094 BON domain; Region: BON; cl02771 357348008095 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 357348008096 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 357348008097 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 357348008098 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 357348008099 putative catalytic residue [active] 357348008100 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357348008101 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348008102 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 357348008103 dimerization interface [polypeptide binding]; other site 357348008104 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 357348008105 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 357348008106 dimer interface [polypeptide binding]; other site 357348008107 putative PBP binding regions; other site 357348008108 ABC-ATPase subunit interface; other site 357348008109 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 357348008110 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 357348008111 putative ligand binding residues [chemical binding]; other site 357348008112 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 357348008113 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 357348008114 Walker A/P-loop; other site 357348008115 ATP binding site [chemical binding]; other site 357348008116 Q-loop/lid; other site 357348008117 ABC transporter signature motif; other site 357348008118 Walker B; other site 357348008119 D-loop; other site 357348008120 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 357348008121 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 357348008122 N-terminal plug; other site 357348008123 ligand-binding site [chemical binding]; other site 357348008124 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 357348008125 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 357348008126 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 357348008127 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 357348008128 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 357348008129 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 357348008130 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 357348008131 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 357348008132 catalytic loop [active] 357348008133 iron binding site [ion binding]; other site 357348008134 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 357348008135 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 357348008136 major facilitator superfamily transporter; Provisional; Region: PRK05122 357348008137 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348008138 putative substrate translocation pore; other site 357348008139 EamA-like transporter family; Region: EamA; pfam00892 357348008140 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 357348008141 EamA-like transporter family; Region: EamA; pfam00892 357348008142 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357348008143 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357348008144 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 357348008145 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 357348008146 catalytic residue [active] 357348008147 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348008148 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357348008149 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 357348008150 putative effector binding pocket; other site 357348008151 dimerization interface [polypeptide binding]; other site 357348008152 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 357348008153 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 357348008154 putative ligand binding site [chemical binding]; other site 357348008155 putative NAD binding site [chemical binding]; other site 357348008156 catalytic site [active] 357348008157 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 357348008158 putative FMN binding site [chemical binding]; other site 357348008159 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 357348008160 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348008161 putative substrate translocation pore; other site 357348008162 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348008163 Major Facilitator Superfamily; Region: MFS_1; pfam07690 357348008164 putative substrate translocation pore; other site 357348008165 fumarylacetoacetase; Region: PLN02856 357348008166 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 357348008167 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 357348008168 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 357348008169 benzoate transport; Region: 2A0115; TIGR00895 357348008170 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348008171 putative substrate translocation pore; other site 357348008172 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348008173 Protein of unknown function (DUF2783); Region: DUF2783; pfam10932 357348008174 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 357348008175 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 357348008176 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 357348008177 EAL domain; Region: EAL; pfam00563 357348008178 Uncharacterized conserved protein [Function unknown]; Region: COG3791 357348008179 Transcriptional regulator [Transcription]; Region: IclR; COG1414 357348008180 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 357348008181 Bacterial transcriptional regulator; Region: IclR; pfam01614 357348008182 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 357348008183 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 357348008184 FAD binding site [chemical binding]; other site 357348008185 substrate binding pocket [chemical binding]; other site 357348008186 catalytic base [active] 357348008187 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 357348008188 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 357348008189 dimer interface [polypeptide binding]; other site 357348008190 decamer (pentamer of dimers) interface [polypeptide binding]; other site 357348008191 catalytic triad [active] 357348008192 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 357348008193 Predicted membrane protein [Function unknown]; Region: COG5393 357348008194 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 357348008195 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 357348008196 Type II transport protein GspH; Region: GspH; pfam12019 357348008197 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 357348008198 ATP cone domain; Region: ATP-cone; pfam03477 357348008199 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 357348008200 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 357348008201 dimer interface [polypeptide binding]; other site 357348008202 active site 357348008203 glycine-pyridoxal phosphate binding site [chemical binding]; other site 357348008204 folate binding site [chemical binding]; other site 357348008205 malonic semialdehyde reductase; Provisional; Region: PRK10538 357348008206 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 357348008207 putative NAD(P) binding site [chemical binding]; other site 357348008208 homodimer interface [polypeptide binding]; other site 357348008209 homotetramer interface [polypeptide binding]; other site 357348008210 active site 357348008211 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 357348008212 active site 357348008213 TolQ protein; Region: tolQ; TIGR02796 357348008214 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 357348008215 TolR protein; Region: tolR; TIGR02801 357348008216 TolA protein; Region: tolA_full; TIGR02794 357348008217 TonB C terminal; Region: TonB_2; pfam13103 357348008218 translocation protein TolB; Provisional; Region: tolB; PRK02889 357348008219 TolB amino-terminal domain; Region: TolB_N; pfam04052 357348008220 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 357348008221 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 357348008222 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 357348008223 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 357348008224 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 357348008225 ligand binding site [chemical binding]; other site 357348008226 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 357348008227 Tetratricopeptide repeat; Region: TPR_6; pfam13174 357348008228 Flagellar transcriptional activator (FlhD); Region: FlhD; cl05012 357348008229 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 357348008230 active site 357348008231 tetramer interface; other site 357348008232 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 357348008233 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 357348008234 putative active site [active] 357348008235 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 357348008236 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 357348008237 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 357348008238 active site 357348008239 motif I; other site 357348008240 motif II; other site 357348008241 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK12457 357348008242 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 357348008243 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357348008244 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 357348008245 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357348008246 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 357348008247 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 357348008248 trimer interface [polypeptide binding]; other site 357348008249 active site 357348008250 substrate binding site [chemical binding]; other site 357348008251 CoA binding site [chemical binding]; other site 357348008252 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 357348008253 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 357348008254 tyrosine kinase; Provisional; Region: PRK11519 357348008255 Chain length determinant protein; Region: Wzz; pfam02706 357348008256 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 357348008257 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 357348008258 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 357348008259 Low molecular weight phosphatase family; Region: LMWPc; cd00115 357348008260 active site 357348008261 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 357348008262 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 357348008263 CoA-binding domain; Region: CoA_binding_3; pfam13727 357348008264 Bacterial sugar transferase; Region: Bac_transf; pfam02397 357348008265 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 357348008266 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 357348008267 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357348008268 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357348008269 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 357348008270 active site 357348008271 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 357348008272 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 357348008273 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 357348008274 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 357348008275 catalytic residue [active] 357348008276 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: PRK13187 357348008277 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 357348008278 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 357348008279 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 357348008280 active site 357348008281 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 357348008282 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 357348008283 Methyltransferase domain; Region: Methyltransf_23; pfam13489 357348008284 Methyltransferase domain; Region: Methyltransf_12; pfam08242 357348008285 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357348008286 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 357348008287 Enoylreductase; Region: PKS_ER; smart00829 357348008288 NAD(P) binding site [chemical binding]; other site 357348008289 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 357348008290 KR domain; Region: KR; pfam08659 357348008291 putative NADP binding site [chemical binding]; other site 357348008292 active site 357348008293 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 357348008294 Sulfatase; Region: Sulfatase; pfam00884 357348008295 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357348008296 NAD(P) binding site [chemical binding]; other site 357348008297 active site 357348008298 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 357348008299 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 357348008300 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 357348008301 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 357348008302 active site 357348008303 motif I; other site 357348008304 motif II; other site 357348008305 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 357348008306 WcbM_like is a subfamily of nucleotidyl transferases; Region: NTP_transferase_WcbM_like; cd06915 357348008307 Substrate binding site; other site 357348008308 Mg++ binding site; other site 357348008309 metal-binding site 357348008310 Mg++ binding site; other site 357348008311 metal-binding site 357348008312 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 357348008313 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 357348008314 dimer interface [polypeptide binding]; other site 357348008315 active site 357348008316 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 357348008317 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 357348008318 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 357348008319 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 357348008320 NADP-binding site; other site 357348008321 homotetramer interface [polypeptide binding]; other site 357348008322 substrate binding site [chemical binding]; other site 357348008323 homodimer interface [polypeptide binding]; other site 357348008324 active site 357348008325 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 357348008326 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357348008327 NAD(P) binding site [chemical binding]; other site 357348008328 active site 357348008329 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357348008330 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 357348008331 Domain of unknown function (DUF4214); Region: DUF4214; pfam13946 357348008332 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 357348008333 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 357348008334 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357348008335 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 357348008336 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 357348008337 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524 357348008338 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 357348008339 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 357348008340 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 357348008341 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357348008342 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 357348008343 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 357348008344 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 357348008345 Substrate binding site; other site 357348008346 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 357348008347 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 357348008348 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 357348008349 putative active site [active] 357348008350 putative dimer interface [polypeptide binding]; other site 357348008351 mechanosensitive channel MscS; Provisional; Region: PRK10334 357348008352 Mechanosensitive ion channel; Region: MS_channel; pfam00924 357348008353 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 357348008354 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 357348008355 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 357348008356 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357348008357 ATP binding site [chemical binding]; other site 357348008358 Mg2+ binding site [ion binding]; other site 357348008359 G-X-G motif; other site 357348008360 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 357348008361 ATP binding site [chemical binding]; other site 357348008362 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 357348008363 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 357348008364 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 357348008365 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 357348008366 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 357348008367 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 357348008368 dimerization interface [polypeptide binding]; other site 357348008369 putative ATP binding site [chemical binding]; other site 357348008370 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 357348008371 DnaA regulatory inactivator Hda; Validated; Region: PRK08903 357348008372 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 357348008373 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 357348008374 poly(A) polymerase; Region: pcnB; TIGR01942 357348008375 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 357348008376 active site 357348008377 NTP binding site [chemical binding]; other site 357348008378 metal binding triad [ion binding]; metal-binding site 357348008379 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 357348008380 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 357348008381 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 357348008382 catalytic center binding site [active] 357348008383 ATP binding site [chemical binding]; other site 357348008384 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 357348008385 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 357348008386 Substrate-binding site [chemical binding]; other site 357348008387 Substrate specificity [chemical binding]; other site 357348008388 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 357348008389 oligomerization interface [polypeptide binding]; other site 357348008390 active site 357348008391 metal binding site [ion binding]; metal-binding site 357348008392 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 357348008393 chorismate binding enzyme; Region: Chorismate_bind; cl10555 357348008394 hypothetical protein; Provisional; Region: PRK07546 357348008395 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 357348008396 homodimer interface [polypeptide binding]; other site 357348008397 substrate-cofactor binding pocket; other site 357348008398 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348008399 catalytic residue [active] 357348008400 chaperone protein DnaJ; Provisional; Region: PRK10767 357348008401 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 357348008402 HSP70 interaction site [polypeptide binding]; other site 357348008403 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 357348008404 Zn binding sites [ion binding]; other site 357348008405 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 357348008406 dimer interface [polypeptide binding]; other site 357348008407 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 357348008408 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 357348008409 nucleotide binding site [chemical binding]; other site 357348008410 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 357348008411 GrpE; Region: GrpE; pfam01025 357348008412 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 357348008413 dimer interface [polypeptide binding]; other site 357348008414 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 357348008415 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 357348008416 RNA binding surface [nucleotide binding]; other site 357348008417 ferrochelatase; Reviewed; Region: hemH; PRK00035 357348008418 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 357348008419 C-terminal domain interface [polypeptide binding]; other site 357348008420 active site 357348008421 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 357348008422 active site 357348008423 N-terminal domain interface [polypeptide binding]; other site 357348008424 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 357348008425 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 357348008426 NAD(+)/NADH kinase family protein; Provisional; Region: ppnK; PRK02155 357348008427 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 357348008428 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 357348008429 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 357348008430 Walker A/P-loop; other site 357348008431 ATP binding site [chemical binding]; other site 357348008432 Q-loop/lid; other site 357348008433 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 357348008434 ABC transporter signature motif; other site 357348008435 Walker B; other site 357348008436 D-loop; other site 357348008437 H-loop/switch region; other site 357348008438 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 357348008439 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 357348008440 metal binding triad; other site 357348008441 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 357348008442 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 357348008443 metal binding triad; other site 357348008444 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 357348008445 TIGR02099 family protein; Region: TIGR02099 357348008446 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 357348008447 nitrilase; Region: PLN02798 357348008448 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 357348008449 putative active site [active] 357348008450 catalytic triad [active] 357348008451 dimer interface [polypeptide binding]; other site 357348008452 protease TldD; Provisional; Region: tldD; PRK10735 357348008453 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 357348008454 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 357348008455 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 357348008456 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 357348008457 heme-binding site [chemical binding]; other site 357348008458 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 357348008459 FAD binding pocket [chemical binding]; other site 357348008460 FAD binding motif [chemical binding]; other site 357348008461 phosphate binding motif [ion binding]; other site 357348008462 beta-alpha-beta structure motif; other site 357348008463 NAD binding pocket [chemical binding]; other site 357348008464 Heme binding pocket [chemical binding]; other site 357348008465 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 357348008466 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 357348008467 FAD binding domain; Region: FAD_binding_4; pfam01565 357348008468 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 357348008469 FAD binding domain; Region: FAD_binding_4; pfam01565 357348008470 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 357348008471 FAD binding domain; Region: FAD_binding_4; pfam01565 357348008472 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 357348008473 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 357348008474 Cysteine-rich domain; Region: CCG; pfam02754 357348008475 Cysteine-rich domain; Region: CCG; pfam02754 357348008476 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 357348008477 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 357348008478 catalytic residue [active] 357348008479 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 357348008480 pyrroline-5-carboxylate reductase; Region: PLN02688 357348008481 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 357348008482 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348008483 dimer interface [polypeptide binding]; other site 357348008484 conserved gate region; other site 357348008485 ABC-ATPase subunit interface; other site 357348008486 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 357348008487 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 357348008488 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357348008489 Walker A/P-loop; other site 357348008490 ATP binding site [chemical binding]; other site 357348008491 Q-loop/lid; other site 357348008492 ABC transporter signature motif; other site 357348008493 Walker B; other site 357348008494 D-loop; other site 357348008495 H-loop/switch region; other site 357348008496 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 357348008497 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 357348008498 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 357348008499 active site 357348008500 phosphonate C-P lyase system protein PhnL; Region: CP_lyasePhnL; TIGR02324 357348008501 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357348008502 Walker A/P-loop; other site 357348008503 ATP binding site [chemical binding]; other site 357348008504 Q-loop/lid; other site 357348008505 ABC transporter signature motif; other site 357348008506 Walker B; other site 357348008507 D-loop; other site 357348008508 H-loop/switch region; other site 357348008509 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 357348008510 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 357348008511 Walker A/P-loop; other site 357348008512 ATP binding site [chemical binding]; other site 357348008513 Q-loop/lid; other site 357348008514 ABC transporter signature motif; other site 357348008515 Walker B; other site 357348008516 D-loop; other site 357348008517 H-loop/switch region; other site 357348008518 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 357348008519 Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007 357348008520 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 357348008521 carbon-phosphorus lyase complex subunit; Validated; Region: phnH; PRK10147 357348008522 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 357348008523 phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325 357348008524 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 357348008525 DNA-binding site [nucleotide binding]; DNA binding site 357348008526 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 357348008527 putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223 357348008528 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 357348008529 active site 357348008530 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 357348008531 UbiA prenyltransferase family; Region: UbiA; pfam01040 357348008532 Predicted transcriptional regulators [Transcription]; Region: COG1733 357348008533 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 357348008534 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 357348008535 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 357348008536 dimerization interface [polypeptide binding]; other site 357348008537 DPS ferroxidase diiron center [ion binding]; other site 357348008538 ion pore; other site 357348008539 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 357348008540 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 357348008541 dimer interface [polypeptide binding]; other site 357348008542 active site 357348008543 heme binding site [chemical binding]; other site 357348008544 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 357348008545 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357348008546 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348008547 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 357348008548 dimerization interface [polypeptide binding]; other site 357348008549 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 357348008550 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 357348008551 generic binding surface II; other site 357348008552 ssDNA binding site; other site 357348008553 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 357348008554 ATP binding site [chemical binding]; other site 357348008555 putative Mg++ binding site [ion binding]; other site 357348008556 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 357348008557 nucleotide binding region [chemical binding]; other site 357348008558 ATP-binding site [chemical binding]; other site 357348008559 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 357348008560 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 357348008561 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 357348008562 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 357348008563 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 357348008564 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 357348008565 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 357348008566 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 357348008567 Protein export membrane protein; Region: SecD_SecF; cl14618 357348008568 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 357348008569 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 357348008570 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 357348008571 Protein export membrane protein; Region: SecD_SecF; pfam02355 357348008572 citrate-proton symporter; Provisional; Region: PRK15075 357348008573 Uncharacterized conserved protein [Function unknown]; Region: COG2353 357348008574 YceI-like domain; Region: YceI; smart00867 357348008575 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 357348008576 Paraquat-inducible protein A; Region: PqiA; pfam04403 357348008577 Paraquat-inducible protein A; Region: PqiA; pfam04403 357348008578 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 357348008579 mce related protein; Region: MCE; pfam02470 357348008580 mce related protein; Region: MCE; pfam02470 357348008581 Protein of unknown function (DUF330); Region: DUF330; pfam03886 357348008582 Site-specific recombinase; Region: SpecificRecomb; pfam10136 357348008583 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 357348008584 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 357348008585 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 357348008586 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 357348008587 Predicted transcriptional regulator [Transcription]; Region: COG2378 357348008588 HTH domain; Region: HTH_11; pfam08279 357348008589 WYL domain; Region: WYL; pfam13280 357348008590 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 357348008591 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 357348008592 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 357348008593 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 357348008594 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 357348008595 ligand binding site [chemical binding]; other site 357348008596 homodimer interface [polypeptide binding]; other site 357348008597 NAD(P) binding site [chemical binding]; other site 357348008598 trimer interface B [polypeptide binding]; other site 357348008599 trimer interface A [polypeptide binding]; other site 357348008600 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 357348008601 nudix motif; other site 357348008602 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 357348008603 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 357348008604 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 357348008605 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 357348008606 active site 357348008607 FMN binding site [chemical binding]; other site 357348008608 substrate binding site [chemical binding]; other site 357348008609 3Fe-4S cluster binding site [ion binding]; other site 357348008610 Transposase domain (DUF772); Region: DUF772; pfam05598 357348008611 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 357348008612 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 357348008613 putative glutathione S-transferase; Provisional; Region: PRK10357 357348008614 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 357348008615 putative C-terminal domain interface [polypeptide binding]; other site 357348008616 putative GSH binding site (G-site) [chemical binding]; other site 357348008617 putative dimer interface [polypeptide binding]; other site 357348008618 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 357348008619 dimer interface [polypeptide binding]; other site 357348008620 N-terminal domain interface [polypeptide binding]; other site 357348008621 putative substrate binding pocket (H-site) [chemical binding]; other site 357348008622 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 357348008623 proline aminopeptidase P II; Provisional; Region: PRK10879 357348008624 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 357348008625 active site 357348008626 hypothetical protein; Provisional; Region: PRK06996 357348008627 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 357348008628 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 357348008629 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 357348008630 FMN binding site [chemical binding]; other site 357348008631 active site 357348008632 catalytic residues [active] 357348008633 substrate binding site [chemical binding]; other site 357348008634 DNA-binding protein Fis; Provisional; Region: PRK01905 357348008635 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 357348008636 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 357348008637 purine monophosphate binding site [chemical binding]; other site 357348008638 dimer interface [polypeptide binding]; other site 357348008639 putative catalytic residues [active] 357348008640 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 357348008641 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 357348008642 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 357348008643 active site 357348008644 putative DNA-binding cleft [nucleotide binding]; other site 357348008645 dimer interface [polypeptide binding]; other site 357348008646 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 357348008647 RuvA N terminal domain; Region: RuvA_N; pfam01330 357348008648 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 357348008649 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 357348008650 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357348008651 Walker A motif; other site 357348008652 ATP binding site [chemical binding]; other site 357348008653 Walker B motif; other site 357348008654 arginine finger; other site 357348008655 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 357348008656 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 357348008657 Putative ParB-like nuclease; Region: ParBc_2; cl17538 357348008658 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 357348008659 catalytic core [active] 357348008660 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 357348008661 putative active site [active] 357348008662 dimerization interface [polypeptide binding]; other site 357348008663 putative tRNAtyr binding site [nucleotide binding]; other site 357348008664 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 357348008665 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 357348008666 active site 357348008667 HIGH motif; other site 357348008668 dimer interface [polypeptide binding]; other site 357348008669 KMSKS motif; other site 357348008670 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 357348008671 RNA binding surface [nucleotide binding]; other site 357348008672 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 357348008673 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 357348008674 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 357348008675 C-terminal domain interface [polypeptide binding]; other site 357348008676 GSH binding site (G-site) [chemical binding]; other site 357348008677 dimer interface [polypeptide binding]; other site 357348008678 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 357348008679 N-terminal domain interface [polypeptide binding]; other site 357348008680 putative dimer interface [polypeptide binding]; other site 357348008681 active site 357348008682 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 357348008683 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 357348008684 C-terminal domain interface [polypeptide binding]; other site 357348008685 GSH binding site (G-site) [chemical binding]; other site 357348008686 dimer interface [polypeptide binding]; other site 357348008687 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 357348008688 N-terminal domain interface [polypeptide binding]; other site 357348008689 dimer interface [polypeptide binding]; other site 357348008690 substrate binding pocket (H-site) [chemical binding]; other site 357348008691 Cupin; Region: Cupin_6; pfam12852 357348008692 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357348008693 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357348008694 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 357348008695 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 357348008696 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 357348008697 23S rRNA interface [nucleotide binding]; other site 357348008698 L3 interface [polypeptide binding]; other site 357348008699 OsmC-like protein; Region: OsmC; cl00767 357348008700 Protein of unknown function (DUF3025); Region: DUF3025; pfam11227 357348008701 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 357348008702 active site 357348008703 substrate binding pocket [chemical binding]; other site 357348008704 dimer interface [polypeptide binding]; other site 357348008705 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 357348008706 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 357348008707 putative active site [active] 357348008708 putative dimer interface [polypeptide binding]; other site 357348008709 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 357348008710 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 357348008711 putative dimer interface [polypeptide binding]; other site 357348008712 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 357348008713 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 357348008714 putative dimer interface [polypeptide binding]; other site 357348008715 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 357348008716 oligomerisation interface [polypeptide binding]; other site 357348008717 mobile loop; other site 357348008718 roof hairpin; other site 357348008719 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 357348008720 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 357348008721 Walker A/P-loop; other site 357348008722 ATP binding site [chemical binding]; other site 357348008723 Q-loop/lid; other site 357348008724 ABC transporter signature motif; other site 357348008725 Walker B; other site 357348008726 D-loop; other site 357348008727 H-loop/switch region; other site 357348008728 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 357348008729 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348008730 dimer interface [polypeptide binding]; other site 357348008731 conserved gate region; other site 357348008732 putative PBP binding loops; other site 357348008733 ABC-ATPase subunit interface; other site 357348008734 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 357348008735 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348008736 dimer interface [polypeptide binding]; other site 357348008737 conserved gate region; other site 357348008738 putative PBP binding loops; other site 357348008739 ABC-ATPase subunit interface; other site 357348008740 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 357348008741 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 357348008742 substrate binding pocket [chemical binding]; other site 357348008743 membrane-bound complex binding site; other site 357348008744 hinge residues; other site 357348008745 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 357348008746 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 357348008747 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 357348008748 NAD(P) binding site [chemical binding]; other site 357348008749 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357348008750 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348008751 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 357348008752 dimerization interface [polypeptide binding]; other site 357348008753 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 357348008754 adenylosuccinate lyase; Provisional; Region: PRK09285 357348008755 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 357348008756 tetramer interface [polypeptide binding]; other site 357348008757 active site 357348008758 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 357348008759 ATP-binding site [chemical binding]; other site 357348008760 Gluconate-6-phosphate binding site [chemical binding]; other site 357348008761 Shikimate kinase; Region: SKI; pfam01202 357348008762 GntP family permease; Region: GntP_permease; pfam02447 357348008763 fructuronate transporter; Provisional; Region: PRK10034; cl15264 357348008764 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 357348008765 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 357348008766 active site 357348008767 intersubunit interface [polypeptide binding]; other site 357348008768 catalytic residue [active] 357348008769 phosphogluconate dehydratase; Validated; Region: PRK09054 357348008770 6-phosphogluconate dehydratase; Region: edd; TIGR01196 357348008771 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 357348008772 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 357348008773 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 357348008774 putative active site [active] 357348008775 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 357348008776 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 357348008777 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 357348008778 putative catalytic cysteine [active] 357348008779 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 357348008780 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 357348008781 Lipopolysaccharide-assembly; Region: LptE; cl01125 357348008782 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 357348008783 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 357348008784 HIGH motif; other site 357348008785 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 357348008786 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 357348008787 active site 357348008788 KMSKS motif; other site 357348008789 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 357348008790 tRNA binding surface [nucleotide binding]; other site 357348008791 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 357348008792 TolR protein; Region: tolR; TIGR02801 357348008793 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 357348008794 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 357348008795 dihydrodipicolinate reductase; Provisional; Region: PRK00048 357348008796 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 357348008797 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 357348008798 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 357348008799 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 357348008800 ferric uptake regulator; Provisional; Region: fur; PRK09462 357348008801 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 357348008802 metal binding site 2 [ion binding]; metal-binding site 357348008803 putative DNA binding helix; other site 357348008804 metal binding site 1 [ion binding]; metal-binding site 357348008805 dimer interface [polypeptide binding]; other site 357348008806 structural Zn2+ binding site [ion binding]; other site 357348008807 ureidoglycolate hydrolase; Provisional; Region: PRK13395 357348008808 allantoicase; Provisional; Region: PRK13257 357348008809 Allantoicase repeat; Region: Allantoicase; pfam03561 357348008810 Allantoicase repeat; Region: Allantoicase; pfam03561 357348008811 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK13027 357348008812 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 357348008813 Transcriptional regulators [Transcription]; Region: FadR; COG2186 357348008814 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 357348008815 DNA-binding site [nucleotide binding]; DNA binding site 357348008816 FCD domain; Region: FCD; pfam07729 357348008817 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 357348008818 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348008819 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425 357348008820 dimerization interface [polypeptide binding]; other site 357348008821 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 357348008822 active site clefts [active] 357348008823 zinc binding site [ion binding]; other site 357348008824 dimer interface [polypeptide binding]; other site 357348008825 cyanate hydratase; Validated; Region: PRK02866 357348008826 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 357348008827 oligomer interface [polypeptide binding]; other site 357348008828 active site 357348008829 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 357348008830 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348008831 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 357348008832 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 357348008833 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 357348008834 transketolase; Reviewed; Region: PRK12753 357348008835 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 357348008836 TPP-binding site [chemical binding]; other site 357348008837 dimer interface [polypeptide binding]; other site 357348008838 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 357348008839 PYR/PP interface [polypeptide binding]; other site 357348008840 dimer interface [polypeptide binding]; other site 357348008841 TPP binding site [chemical binding]; other site 357348008842 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 357348008843 spermidine synthase; Provisional; Region: PRK00811 357348008844 Spermidine synthase [Amino acid transport and metabolism]; Region: SpeE; COG0421 357348008845 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 357348008846 putative dimer interface [polypeptide binding]; other site 357348008847 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 357348008848 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 357348008849 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 357348008850 putative RNAase interaction site [polypeptide binding]; other site 357348008851 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 357348008852 active site 357348008853 barstar interaction site; other site 357348008854 malic enzyme; Reviewed; Region: PRK12862 357348008855 Malic enzyme, N-terminal domain; Region: malic; pfam00390 357348008856 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 357348008857 putative NAD(P) binding site [chemical binding]; other site 357348008858 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 357348008859 thiamine monophosphate kinase; Provisional; Region: PRK05731 357348008860 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 357348008861 ATP binding site [chemical binding]; other site 357348008862 dimerization interface [polypeptide binding]; other site 357348008863 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 357348008864 tetramer interfaces [polypeptide binding]; other site 357348008865 binuclear metal-binding site [ion binding]; other site 357348008866 Competence-damaged protein; Region: CinA; pfam02464 357348008867 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 357348008868 active site 357348008869 dimer interface [polypeptide binding]; other site 357348008870 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 357348008871 active site 357348008872 catalytic residues [active] 357348008873 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 357348008874 classical (c) SDRs; Region: SDR_c; cd05233 357348008875 NAD(P) binding site [chemical binding]; other site 357348008876 active site 357348008877 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 357348008878 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 357348008879 TM-ABC transporter signature motif; other site 357348008880 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 357348008881 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 357348008882 Walker A/P-loop; other site 357348008883 ATP binding site [chemical binding]; other site 357348008884 Q-loop/lid; other site 357348008885 ABC transporter signature motif; other site 357348008886 Walker B; other site 357348008887 D-loop; other site 357348008888 H-loop/switch region; other site 357348008889 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 357348008890 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 357348008891 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 357348008892 ligand binding site [chemical binding]; other site 357348008893 short chain dehydrogenase; Provisional; Region: PRK07063 357348008894 classical (c) SDRs; Region: SDR_c; cd05233 357348008895 NAD(P) binding site [chemical binding]; other site 357348008896 active site 357348008897 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 357348008898 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 357348008899 active site 357348008900 intersubunit interface [polypeptide binding]; other site 357348008901 catalytic residue [active] 357348008902 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 357348008903 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 357348008904 Transcriptional regulator [Transcription]; Region: IclR; COG1414 357348008905 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 357348008906 Bacterial transcriptional regulator; Region: IclR; pfam01614 357348008907 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 357348008908 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 357348008909 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 357348008910 Transglycosylase; Region: Transgly; cl17702 357348008911 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 357348008912 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 357348008913 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 357348008914 shikimate binding site; other site 357348008915 NAD(P) binding site [chemical binding]; other site 357348008916 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 357348008917 RNB domain; Region: RNB; pfam00773 357348008918 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 357348008919 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 357348008920 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 357348008921 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 357348008922 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 357348008923 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 357348008924 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 357348008925 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 357348008926 catalytic residues [active] 357348008927 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 357348008928 Dehydroquinase class II; Region: DHquinase_II; pfam01220 357348008929 active site 357348008930 trimer interface [polypeptide binding]; other site 357348008931 dimer interface [polypeptide binding]; other site 357348008932 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 357348008933 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 357348008934 carboxyltransferase (CT) interaction site; other site 357348008935 biotinylation site [posttranslational modification]; other site 357348008936 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 357348008937 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 357348008938 ATP-grasp domain; Region: ATP-grasp_4; cl17255 357348008939 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 357348008940 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 357348008941 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 357348008942 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357348008943 S-adenosylmethionine binding site [chemical binding]; other site 357348008944 MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098 357348008945 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 357348008946 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 357348008947 dimer interface [polypeptide binding]; other site 357348008948 catalytic triad [active] 357348008949 peroxidatic and resolving cysteines [active] 357348008950 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 357348008951 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 357348008952 substrate binding site [chemical binding]; other site 357348008953 ATP binding site [chemical binding]; other site 357348008954 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 357348008955 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 357348008956 dimer interface [polypeptide binding]; other site 357348008957 putative radical transfer pathway; other site 357348008958 diiron center [ion binding]; other site 357348008959 tyrosyl radical; other site 357348008960 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 357348008961 ATP cone domain; Region: ATP-cone; pfam03477 357348008962 Class I ribonucleotide reductase; Region: RNR_I; cd01679 357348008963 active site 357348008964 dimer interface [polypeptide binding]; other site 357348008965 catalytic residues [active] 357348008966 effector binding site; other site 357348008967 R2 peptide binding site; other site 357348008968 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 357348008969 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 357348008970 amidase catalytic site [active] 357348008971 Zn binding residues [ion binding]; other site 357348008972 substrate binding site [chemical binding]; other site 357348008973 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 357348008974 signal recognition particle protein; Provisional; Region: PRK10867 357348008975 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 357348008976 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 357348008977 P loop; other site 357348008978 GTP binding site [chemical binding]; other site 357348008979 Signal peptide binding domain; Region: SRP_SPB; pfam02978 357348008980 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 357348008981 active site 357348008982 MarC family integral membrane protein; Region: MarC; cl00919 357348008983 prolyl-tRNA synthetase; Provisional; Region: PRK09194 357348008984 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 357348008985 dimer interface [polypeptide binding]; other site 357348008986 motif 1; other site 357348008987 active site 357348008988 motif 2; other site 357348008989 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 357348008990 putative deacylase active site [active] 357348008991 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 357348008992 active site 357348008993 motif 3; other site 357348008994 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 357348008995 anticodon binding site; other site 357348008996 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 357348008997 putative active site [active] 357348008998 Ap4A binding site [chemical binding]; other site 357348008999 nudix motif; other site 357348009000 putative metal binding site [ion binding]; other site 357348009001 CNP1-like family; Region: CNP1; pfam08750 357348009002 gamma-glutamyl kinase; Provisional; Region: PRK05429 357348009003 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 357348009004 nucleotide binding site [chemical binding]; other site 357348009005 homotetrameric interface [polypeptide binding]; other site 357348009006 putative phosphate binding site [ion binding]; other site 357348009007 putative allosteric binding site; other site 357348009008 PUA domain; Region: PUA; pfam01472 357348009009 GTPase CgtA; Reviewed; Region: obgE; PRK12298 357348009010 GTP1/OBG; Region: GTP1_OBG; pfam01018 357348009011 Obg GTPase; Region: Obg; cd01898 357348009012 G1 box; other site 357348009013 GTP/Mg2+ binding site [chemical binding]; other site 357348009014 Switch I region; other site 357348009015 G2 box; other site 357348009016 G3 box; other site 357348009017 Switch II region; other site 357348009018 G4 box; other site 357348009019 G5 box; other site 357348009020 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 357348009021 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 357348009022 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 357348009023 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 357348009024 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 357348009025 substrate binding pocket [chemical binding]; other site 357348009026 chain length determination region; other site 357348009027 substrate-Mg2+ binding site; other site 357348009028 catalytic residues [active] 357348009029 aspartate-rich region 1; other site 357348009030 active site lid residues [active] 357348009031 aspartate-rich region 2; other site 357348009032 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 357348009033 Domain of unknown function DUF21; Region: DUF21; pfam01595 357348009034 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 357348009035 Transporter associated domain; Region: CorC_HlyC; smart01091 357348009036 Type II/IV secretion system protein; Region: T2SE; pfam00437 357348009037 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 357348009038 Walker A motif; other site 357348009039 ATP binding site [chemical binding]; other site 357348009040 Walker B motif; other site 357348009041 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 357348009042 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 357348009043 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 357348009044 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 357348009045 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 357348009046 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 357348009047 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 357348009048 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 357348009049 CoA-binding site [chemical binding]; other site 357348009050 ATP-binding [chemical binding]; other site 357348009051 hypothetical protein; Provisional; Region: PRK05287 357348009052 Domain of unknown function (DUF329); Region: DUF329; pfam03884 357348009053 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 357348009054 active site 357348009055 8-oxo-dGMP binding site [chemical binding]; other site 357348009056 nudix motif; other site 357348009057 metal binding site [ion binding]; metal-binding site 357348009058 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 357348009059 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357348009060 Walker A motif; other site 357348009061 ATP binding site [chemical binding]; other site 357348009062 Walker B motif; other site 357348009063 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 357348009064 heterotetramer interface [polypeptide binding]; other site 357348009065 active site pocket [active] 357348009066 cleavage site 357348009067 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 357348009068 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 357348009069 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 357348009070 SEC-C motif; Region: SEC-C; pfam02810 357348009071 Protein of unknown function (DUF721); Region: DUF721; pfam05258 357348009072 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 357348009073 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 357348009074 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 357348009075 catalytic triad [active] 357348009076 dimer interface [polypeptide binding]; other site 357348009077 cell division protein FtsZ; Validated; Region: PRK09330 357348009078 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 357348009079 nucleotide binding site [chemical binding]; other site 357348009080 SulA interaction site; other site 357348009081 cell division protein FtsA; Region: ftsA; TIGR01174 357348009082 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 357348009083 nucleotide binding site [chemical binding]; other site 357348009084 Cell division protein FtsA; Region: FtsA; pfam14450 357348009085 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 357348009086 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 357348009087 Cell division protein FtsQ; Region: FtsQ; pfam03799 357348009088 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 357348009089 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 357348009090 ATP-grasp domain; Region: ATP-grasp_4; cl17255 357348009091 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 357348009092 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 357348009093 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 357348009094 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 357348009095 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 357348009096 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 357348009097 active site 357348009098 homodimer interface [polypeptide binding]; other site 357348009099 cell division protein FtsW; Region: ftsW; TIGR02614 357348009100 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02006 357348009101 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 357348009102 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 357348009103 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 357348009104 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 357348009105 Mg++ binding site [ion binding]; other site 357348009106 putative catalytic motif [active] 357348009107 putative substrate binding site [chemical binding]; other site 357348009108 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 357348009109 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 357348009110 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 357348009111 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 357348009112 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 357348009113 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 357348009114 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 357348009115 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 357348009116 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 357348009117 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 357348009118 Cell division protein FtsL; Region: FtsL; pfam04999 357348009119 MraW methylase family; Region: Methyltransf_5; cl17771 357348009120 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 357348009121 cell division protein MraZ; Reviewed; Region: PRK00326 357348009122 MraZ protein; Region: MraZ; pfam02381 357348009123 MraZ protein; Region: MraZ; pfam02381 357348009124 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 357348009125 diiron binding motif [ion binding]; other site 357348009126 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 357348009127 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 357348009128 trimer interface [polypeptide binding]; other site 357348009129 eyelet of channel; other site 357348009130 Transposase domain (DUF772); Region: DUF772; pfam05598 357348009131 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 357348009132 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 357348009133 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 357348009134 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 357348009135 acyl-activating enzyme (AAE) consensus motif; other site 357348009136 putative AMP binding site [chemical binding]; other site 357348009137 putative active site [active] 357348009138 putative CoA binding site [chemical binding]; other site 357348009139 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 357348009140 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 357348009141 putative [4Fe-4S] binding site [ion binding]; other site 357348009142 putative molybdopterin cofactor binding site [chemical binding]; other site 357348009143 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 357348009144 putative molybdopterin cofactor binding site; other site 357348009145 enoyl-CoA hydratase; Provisional; Region: PRK05862 357348009146 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 357348009147 substrate binding site [chemical binding]; other site 357348009148 oxyanion hole (OAH) forming residues; other site 357348009149 trimer interface [polypeptide binding]; other site 357348009150 phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288 357348009151 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 357348009152 NAD(P) binding site [chemical binding]; other site 357348009153 catalytic residues [active] 357348009154 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 357348009155 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 357348009156 dimer interface [polypeptide binding]; other site 357348009157 active site 357348009158 enoyl-CoA hydratase; Provisional; Region: PRK08140 357348009159 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 357348009160 substrate binding site [chemical binding]; other site 357348009161 oxyanion hole (OAH) forming residues; other site 357348009162 trimer interface [polypeptide binding]; other site 357348009163 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 357348009164 CoenzymeA binding site [chemical binding]; other site 357348009165 subunit interaction site [polypeptide binding]; other site 357348009166 PHB binding site; other site 357348009167 Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913 357348009168 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 357348009169 active site 357348009170 AMP binding site [chemical binding]; other site 357348009171 homodimer interface [polypeptide binding]; other site 357348009172 acyl-activating enzyme (AAE) consensus motif; other site 357348009173 CoA binding site [chemical binding]; other site 357348009174 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 357348009175 MltA specific insert domain; Region: MltA; smart00925 357348009176 3D domain; Region: 3D; pfam06725 357348009177 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 357348009178 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 357348009179 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 357348009180 substrate binding site [chemical binding]; other site 357348009181 hexamer interface [polypeptide binding]; other site 357348009182 metal binding site [ion binding]; metal-binding site 357348009183 phosphoglycolate phosphatase; Provisional; Region: PRK13222 357348009184 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 357348009185 motif II; other site 357348009186 anthranilate synthase component I; Provisional; Region: PRK13565 357348009187 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 357348009188 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 357348009189 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 357348009190 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 357348009191 glutamine binding [chemical binding]; other site 357348009192 catalytic triad [active] 357348009193 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 357348009194 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 357348009195 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 357348009196 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 357348009197 active site 357348009198 ribulose/triose binding site [chemical binding]; other site 357348009199 phosphate binding site [ion binding]; other site 357348009200 substrate (anthranilate) binding pocket [chemical binding]; other site 357348009201 product (indole) binding pocket [chemical binding]; other site 357348009202 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 357348009203 putative active site [active] 357348009204 putative metal binding residues [ion binding]; other site 357348009205 signature motif; other site 357348009206 putative triphosphate binding site [ion binding]; other site 357348009207 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 357348009208 ligand binding site [chemical binding]; other site 357348009209 active site 357348009210 UGI interface [polypeptide binding]; other site 357348009211 catalytic site [active] 357348009212 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 357348009213 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 357348009214 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 357348009215 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 357348009216 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 357348009217 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 357348009218 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 357348009219 dimerization domain [polypeptide binding]; other site 357348009220 dimer interface [polypeptide binding]; other site 357348009221 catalytic residues [active] 357348009222 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608 357348009223 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 357348009224 GTP-binding protein YchF; Reviewed; Region: PRK09601 357348009225 YchF GTPase; Region: YchF; cd01900 357348009226 G1 box; other site 357348009227 GTP/Mg2+ binding site [chemical binding]; other site 357348009228 Switch I region; other site 357348009229 G2 box; other site 357348009230 Switch II region; other site 357348009231 G3 box; other site 357348009232 G4 box; other site 357348009233 G5 box; other site 357348009234 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 357348009235 NADH dehydrogenase subunit B; Validated; Region: PRK06411 357348009236 Helix-turn-helix domain; Region: HTH_18; pfam12833 357348009237 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 357348009238 Spore germination protein; Region: Spore_permease; cl17796 357348009239 Protein of unknown function (DUF419); Region: DUF419; cl15265 357348009240 Protein of unknown function (DUF419); Region: DUF419; cl15265 357348009241 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 357348009242 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 357348009243 active site 357348009244 catalytic site [active] 357348009245 Protein of unknown function (DUF3761); Region: DUF3761; pfam12587 357348009246 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 357348009247 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357348009248 Walker A/P-loop; other site 357348009249 ATP binding site [chemical binding]; other site 357348009250 Q-loop/lid; other site 357348009251 ABC transporter signature motif; other site 357348009252 Walker B; other site 357348009253 D-loop; other site 357348009254 H-loop/switch region; other site 357348009255 ABC transporter; Region: ABC_tran_2; pfam12848 357348009256 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 357348009257 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 357348009258 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 357348009259 Isochorismatase family; Region: Isochorismatase; pfam00857 357348009260 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 357348009261 catalytic triad [active] 357348009262 conserved cis-peptide bond; other site 357348009263 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 357348009264 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 357348009265 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 357348009266 active site 357348009267 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 357348009268 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 357348009269 tRNA; other site 357348009270 putative tRNA binding site [nucleotide binding]; other site 357348009271 putative NADP binding site [chemical binding]; other site 357348009272 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 357348009273 peptide chain release factor 1; Validated; Region: prfA; PRK00591 357348009274 This domain is found in peptide chain release factors; Region: PCRF; smart00937 357348009275 RF-1 domain; Region: RF-1; pfam00472 357348009276 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 357348009277 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357348009278 S-adenosylmethionine binding site [chemical binding]; other site 357348009279 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 357348009280 putative GSH binding site [chemical binding]; other site 357348009281 catalytic residues [active] 357348009282 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 357348009283 Flavoprotein; Region: Flavoprotein; pfam02441 357348009284 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 357348009285 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 357348009286 putative active site [active] 357348009287 metal binding site [ion binding]; metal-binding site 357348009288 amino acid transporter; Region: 2A0306; TIGR00909 357348009289 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 357348009290 DNA-binding site [nucleotide binding]; DNA binding site 357348009291 RNA-binding motif; other site 357348009292 putative chaperone; Provisional; Region: PRK11678 357348009293 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 357348009294 nucleotide binding site [chemical binding]; other site 357348009295 putative NEF/HSP70 interaction site [polypeptide binding]; other site 357348009296 SBD interface [polypeptide binding]; other site 357348009297 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 357348009298 putative FMN binding site [chemical binding]; other site 357348009299 D-galactonate transporter; Region: 2A0114; TIGR00893 357348009300 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348009301 putative substrate translocation pore; other site 357348009302 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 357348009303 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 357348009304 Protein of unknown function (DUF1415); Region: DUF1415; pfam07209 357348009305 Methyltransferase domain; Region: Methyltransf_32; pfam13679 357348009306 Methyltransferase domain; Region: Methyltransf_31; pfam13847 357348009307 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 357348009308 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357348009309 S-adenosylmethionine binding site [chemical binding]; other site 357348009310 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 357348009311 Water Stress and Hypersensitive response; Region: WHy; smart00769 357348009312 Peptidase family M1; Region: Peptidase_M1; pfam01433 357348009313 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 357348009314 Zn binding site [ion binding]; other site 357348009315 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 357348009316 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 357348009317 HlyD family secretion protein; Region: HlyD_3; pfam13437 357348009318 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 357348009319 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 357348009320 putative active site [active] 357348009321 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 357348009322 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 357348009323 Walker A/P-loop; other site 357348009324 ATP binding site [chemical binding]; other site 357348009325 Q-loop/lid; other site 357348009326 ABC transporter signature motif; other site 357348009327 Walker B; other site 357348009328 D-loop; other site 357348009329 H-loop/switch region; other site 357348009330 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 357348009331 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 357348009332 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 357348009333 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 357348009334 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 357348009335 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 357348009336 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 357348009337 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611 357348009338 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 357348009339 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 357348009340 ligand binding site [chemical binding]; other site 357348009341 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 357348009342 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 357348009343 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 357348009344 Clp amino terminal domain; Region: Clp_N; pfam02861 357348009345 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357348009346 Walker A motif; other site 357348009347 ATP binding site [chemical binding]; other site 357348009348 Walker B motif; other site 357348009349 arginine finger; other site 357348009350 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357348009351 Walker A motif; other site 357348009352 ATP binding site [chemical binding]; other site 357348009353 Walker B motif; other site 357348009354 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 357348009355 type VI secretion protein, VC_A0111 family; Region: VI_chp_1; TIGR03347 357348009356 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 357348009357 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 357348009358 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3518 357348009359 Protein of unknown function (DUF796); Region: DUF796; pfam05638 357348009360 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 357348009361 Protein of unknown function (DUF877); Region: DUF877; pfam05943 357348009362 Protein of unknown function (DUF770); Region: DUF770; pfam05591 357348009363 TPR repeat; Region: TPR_11; pfam13414 357348009364 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357348009365 TPR motif; other site 357348009366 binding surface 357348009367 type VI secretion lipoprotein, VC_A0113 family; Region: VI_chp_3; TIGR03352 357348009368 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 357348009369 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 357348009370 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 357348009371 Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069 357348009372 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 357348009373 DNA methylase; Region: N6_N4_Mtase; pfam01555 357348009374 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 357348009375 Baseplate J-like protein; Region: Baseplate_J; cl01294 357348009376 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 357348009377 Transposase; Region: DDE_Tnp_ISL3; pfam01610 357348009378 PAAR motif; Region: PAAR_motif; pfam05488 357348009379 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 357348009380 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 357348009381 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 357348009382 ATP-binding site [chemical binding]; other site 357348009383 DEAD-like helicases superfamily; Region: DEXDc; smart00487 357348009384 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 357348009385 ATP binding site [chemical binding]; other site 357348009386 putative Mg++ binding site [ion binding]; other site 357348009387 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 357348009388 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 357348009389 nucleotide binding region [chemical binding]; other site 357348009390 ATP-binding site [chemical binding]; other site 357348009391 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 357348009392 ATP binding site [chemical binding]; other site 357348009393 putative Mg++ binding site [ion binding]; other site 357348009394 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 357348009395 nucleotide binding region [chemical binding]; other site 357348009396 ATP-binding site [chemical binding]; other site 357348009397 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 357348009398 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 357348009399 cofactor binding site; other site 357348009400 DNA binding site [nucleotide binding] 357348009401 substrate interaction site [chemical binding]; other site 357348009402 DNA binding domain, excisionase family; Region: excise; TIGR01764 357348009403 phage/plasmid-like protein TIGR03299; Region: LGT_TIGR03299 357348009404 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 357348009405 Transposase domain (DUF772); Region: DUF772; pfam05598 357348009406 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 357348009407 Methyltransferase domain; Region: Methyltransf_27; pfam13708 357348009408 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 357348009409 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 357348009410 non-specific DNA binding site [nucleotide binding]; other site 357348009411 salt bridge; other site 357348009412 sequence-specific DNA binding site [nucleotide binding]; other site 357348009413 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 357348009414 AAA domain; Region: AAA_25; pfam13481 357348009415 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 357348009416 Walker A motif; other site 357348009417 ATP binding site [chemical binding]; other site 357348009418 Walker B motif; other site 357348009419 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 357348009420 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 357348009421 DNA binding site [nucleotide binding] 357348009422 active site 357348009423 Int/Topo IB signature motif; other site 357348009424 Transposase domain (DUF772); Region: DUF772; pfam05598 357348009425 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 357348009426 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 357348009427 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 357348009428 stringent starvation protein A; Provisional; Region: sspA; PRK09481 357348009429 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 357348009430 C-terminal domain interface [polypeptide binding]; other site 357348009431 putative GSH binding site (G-site) [chemical binding]; other site 357348009432 dimer interface [polypeptide binding]; other site 357348009433 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 357348009434 dimer interface [polypeptide binding]; other site 357348009435 N-terminal domain interface [polypeptide binding]; other site 357348009436 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 357348009437 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 357348009438 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 357348009439 Qi binding site; other site 357348009440 intrachain domain interface; other site 357348009441 interchain domain interface [polypeptide binding]; other site 357348009442 heme bH binding site [chemical binding]; other site 357348009443 heme bL binding site [chemical binding]; other site 357348009444 Qo binding site; other site 357348009445 interchain domain interface [polypeptide binding]; other site 357348009446 intrachain domain interface; other site 357348009447 Qi binding site; other site 357348009448 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 357348009449 Qo binding site; other site 357348009450 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 357348009451 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 357348009452 [2Fe-2S] cluster binding site [ion binding]; other site 357348009453 Uncharacterized conserved protein [Function unknown]; Region: COG0327 357348009454 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 357348009455 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 357348009456 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 357348009457 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 357348009458 protein binding site [polypeptide binding]; other site 357348009459 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 357348009460 sec-independent translocase; Provisional; Region: tatB; PRK01919 357348009461 twin arginine translocase protein A; Provisional; Region: tatA; PRK02958 357348009462 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 357348009463 nucleotide binding site/active site [active] 357348009464 HIT family signature motif; other site 357348009465 catalytic residue [active] 357348009466 Predicted membrane protein [Function unknown]; Region: COG3671 357348009467 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 357348009468 metal binding site [ion binding]; metal-binding site 357348009469 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 357348009470 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 357348009471 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 357348009472 substrate binding site [chemical binding]; other site 357348009473 glutamase interaction surface [polypeptide binding]; other site 357348009474 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 357348009475 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 357348009476 catalytic residues [active] 357348009477 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 357348009478 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 357348009479 putative active site [active] 357348009480 oxyanion strand; other site 357348009481 catalytic triad [active] 357348009482 MarC family integral membrane protein; Region: MarC; cl00919 357348009483 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 357348009484 putative active site pocket [active] 357348009485 4-fold oligomerization interface [polypeptide binding]; other site 357348009486 metal binding residues [ion binding]; metal-binding site 357348009487 3-fold/trimer interface [polypeptide binding]; other site 357348009488 histidinol-phosphate aminotransferase; Provisional; Region: PRK04870 357348009489 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 357348009490 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348009491 homodimer interface [polypeptide binding]; other site 357348009492 catalytic residue [active] 357348009493 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 357348009494 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 357348009495 NAD binding site [chemical binding]; other site 357348009496 dimerization interface [polypeptide binding]; other site 357348009497 product binding site; other site 357348009498 substrate binding site [chemical binding]; other site 357348009499 zinc binding site [ion binding]; other site 357348009500 catalytic residues [active] 357348009501 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 357348009502 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 357348009503 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 357348009504 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 357348009505 hinge; other site 357348009506 active site 357348009507 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 357348009508 ABC-2 type transporter; Region: ABC2_membrane; cl17235 357348009509 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 357348009510 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 357348009511 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 357348009512 Walker A/P-loop; other site 357348009513 ATP binding site [chemical binding]; other site 357348009514 Q-loop/lid; other site 357348009515 ABC transporter signature motif; other site 357348009516 Walker B; other site 357348009517 D-loop; other site 357348009518 H-loop/switch region; other site 357348009519 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 357348009520 anti sigma factor interaction site; other site 357348009521 regulatory phosphorylation site [posttranslational modification]; other site 357348009522 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 357348009523 VacJ like lipoprotein; Region: VacJ; cl01073 357348009524 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 357348009525 mce related protein; Region: MCE; pfam02470 357348009526 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 357348009527 Permease; Region: Permease; pfam02405 357348009528 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 357348009529 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 357348009530 Walker A/P-loop; other site 357348009531 ATP binding site [chemical binding]; other site 357348009532 Q-loop/lid; other site 357348009533 ABC transporter signature motif; other site 357348009534 Walker B; other site 357348009535 D-loop; other site 357348009536 H-loop/switch region; other site 357348009537 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 357348009538 thiamine phosphate binding site [chemical binding]; other site 357348009539 active site 357348009540 pyrophosphate binding site [ion binding]; other site 357348009541 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 357348009542 ThiS interaction site; other site 357348009543 putative active site [active] 357348009544 tetramer interface [polypeptide binding]; other site 357348009545 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 357348009546 thiS-thiF/thiG interaction site; other site 357348009547 FAD dependent oxidoreductase; Region: DAO; pfam01266 357348009548 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 357348009549 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 357348009550 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 357348009551 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 357348009552 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 357348009553 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 357348009554 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 357348009555 amino acid carrier protein; Region: agcS; TIGR00835 357348009556 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 357348009557 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 357348009558 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 357348009559 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 357348009560 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 357348009561 active site 357348009562 dimer interface [polypeptide binding]; other site 357348009563 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 357348009564 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 357348009565 active site 357348009566 FMN binding site [chemical binding]; other site 357348009567 substrate binding site [chemical binding]; other site 357348009568 3Fe-4S cluster binding site [ion binding]; other site 357348009569 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 357348009570 domain interface; other site 357348009571 Transposase IS200 like; Region: Y1_Tnp; cl00848 357348009572 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 357348009573 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 357348009574 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 357348009575 active site 357348009576 catalytic site [active] 357348009577 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 357348009578 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 357348009579 Walker A/P-loop; other site 357348009580 ATP binding site [chemical binding]; other site 357348009581 Q-loop/lid; other site 357348009582 ABC transporter signature motif; other site 357348009583 Walker B; other site 357348009584 D-loop; other site 357348009585 H-loop/switch region; other site 357348009586 TOBE domain; Region: TOBE_2; pfam08402 357348009587 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 357348009588 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348009589 dimer interface [polypeptide binding]; other site 357348009590 conserved gate region; other site 357348009591 putative PBP binding loops; other site 357348009592 ABC-ATPase subunit interface; other site 357348009593 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348009594 dimer interface [polypeptide binding]; other site 357348009595 conserved gate region; other site 357348009596 putative PBP binding loops; other site 357348009597 ABC-ATPase subunit interface; other site 357348009598 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 357348009599 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 357348009600 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 357348009601 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 357348009602 Zn2+ binding site [ion binding]; other site 357348009603 Mg2+ binding site [ion binding]; other site 357348009604 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 357348009605 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 357348009606 active site 357348009607 dimer interface [polypeptide binding]; other site 357348009608 metal binding site [ion binding]; metal-binding site 357348009609 shikimate kinase; Reviewed; Region: aroK; PRK00131 357348009610 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 357348009611 ADP binding site [chemical binding]; other site 357348009612 magnesium binding site [ion binding]; other site 357348009613 putative shikimate binding site; other site 357348009614 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 357348009615 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 357348009616 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 357348009617 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 357348009618 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 357348009619 Transglycosylase; Region: Transgly; pfam00912 357348009620 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 357348009621 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 357348009622 putative iron binding site [ion binding]; other site 357348009623 diaminopimelate decarboxylase; Region: lysA; TIGR01048 357348009624 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 357348009625 active site 357348009626 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 357348009627 substrate binding site [chemical binding]; other site 357348009628 catalytic residues [active] 357348009629 dimer interface [polypeptide binding]; other site 357348009630 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 357348009631 TMAO/DMSO reductase; Reviewed; Region: PRK05363 357348009632 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 357348009633 Moco binding site; other site 357348009634 metal coordination site [ion binding]; other site 357348009635 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 357348009636 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 357348009637 ResB-like family; Region: ResB; pfam05140 357348009638 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 357348009639 ResB-like family; Region: ResB; pfam05140 357348009640 Cytochrome c553 [Energy production and conversion]; Region: COG2863 357348009641 Cytochrome c; Region: Cytochrom_C; cl11414 357348009642 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 357348009643 G1 box; other site 357348009644 GTP/Mg2+ binding site [chemical binding]; other site 357348009645 Switch I region; other site 357348009646 G2 box; other site 357348009647 G3 box; other site 357348009648 Switch II region; other site 357348009649 G4 box; other site 357348009650 G5 box; other site 357348009651 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 357348009652 dimer interface [polypeptide binding]; other site 357348009653 active site 357348009654 aspartate-rich active site metal binding site; other site 357348009655 allosteric magnesium binding site [ion binding]; other site 357348009656 Schiff base residues; other site 357348009657 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 357348009658 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 357348009659 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 357348009660 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 357348009661 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 357348009662 DsbD alpha interface [polypeptide binding]; other site 357348009663 catalytic residues [active] 357348009664 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 357348009665 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 357348009666 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 357348009667 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 357348009668 alphaNTD homodimer interface [polypeptide binding]; other site 357348009669 alphaNTD - beta interaction site [polypeptide binding]; other site 357348009670 alphaNTD - beta' interaction site [polypeptide binding]; other site 357348009671 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 357348009672 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 357348009673 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 357348009674 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 357348009675 RNA binding surface [nucleotide binding]; other site 357348009676 30S ribosomal protein S11; Validated; Region: PRK05309 357348009677 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 357348009678 30S ribosomal protein S13; Region: bact_S13; TIGR03631 357348009679 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 357348009680 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 357348009681 rRNA binding site [nucleotide binding]; other site 357348009682 predicted 30S ribosome binding site; other site 357348009683 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 357348009684 SecY translocase; Region: SecY; pfam00344 357348009685 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 357348009686 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 357348009687 23S rRNA binding site [nucleotide binding]; other site 357348009688 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 357348009689 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 357348009690 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 357348009691 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 357348009692 5S rRNA interface [nucleotide binding]; other site 357348009693 L27 interface [polypeptide binding]; other site 357348009694 23S rRNA interface [nucleotide binding]; other site 357348009695 L5 interface [polypeptide binding]; other site 357348009696 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 357348009697 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 357348009698 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 357348009699 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 357348009700 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 357348009701 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 357348009702 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 357348009703 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 357348009704 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 357348009705 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 357348009706 RNA binding site [nucleotide binding]; other site 357348009707 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 357348009708 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 357348009709 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 357348009710 23S rRNA interface [nucleotide binding]; other site 357348009711 putative translocon interaction site; other site 357348009712 signal recognition particle (SRP54) interaction site; other site 357348009713 L23 interface [polypeptide binding]; other site 357348009714 trigger factor interaction site; other site 357348009715 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 357348009716 23S rRNA interface [nucleotide binding]; other site 357348009717 5S rRNA interface [nucleotide binding]; other site 357348009718 putative antibiotic binding site [chemical binding]; other site 357348009719 L25 interface [polypeptide binding]; other site 357348009720 L27 interface [polypeptide binding]; other site 357348009721 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 357348009722 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 357348009723 G-X-X-G motif; other site 357348009724 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 357348009725 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 357348009726 putative translocon binding site; other site 357348009727 protein-rRNA interface [nucleotide binding]; other site 357348009728 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 357348009729 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 357348009730 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 357348009731 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 357348009732 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 357348009733 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 357348009734 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 357348009735 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 357348009736 elongation factor Tu; Reviewed; Region: PRK00049 357348009737 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 357348009738 G1 box; other site 357348009739 GEF interaction site [polypeptide binding]; other site 357348009740 GTP/Mg2+ binding site [chemical binding]; other site 357348009741 Switch I region; other site 357348009742 G2 box; other site 357348009743 G3 box; other site 357348009744 Switch II region; other site 357348009745 G4 box; other site 357348009746 G5 box; other site 357348009747 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 357348009748 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 357348009749 Antibiotic Binding Site [chemical binding]; other site 357348009750 elongation factor G; Reviewed; Region: PRK00007 357348009751 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 357348009752 G1 box; other site 357348009753 putative GEF interaction site [polypeptide binding]; other site 357348009754 GTP/Mg2+ binding site [chemical binding]; other site 357348009755 Switch I region; other site 357348009756 G2 box; other site 357348009757 G3 box; other site 357348009758 Switch II region; other site 357348009759 G4 box; other site 357348009760 G5 box; other site 357348009761 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 357348009762 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 357348009763 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 357348009764 30S ribosomal protein S7; Validated; Region: PRK05302 357348009765 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 357348009766 S17 interaction site [polypeptide binding]; other site 357348009767 S8 interaction site; other site 357348009768 16S rRNA interaction site [nucleotide binding]; other site 357348009769 streptomycin interaction site [chemical binding]; other site 357348009770 23S rRNA interaction site [nucleotide binding]; other site 357348009771 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 357348009772 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 357348009773 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 357348009774 ATP binding site [chemical binding]; other site 357348009775 putative Mg++ binding site [ion binding]; other site 357348009776 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 357348009777 nucleotide binding region [chemical binding]; other site 357348009778 ATP-binding site [chemical binding]; other site 357348009779 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 357348009780 HRDC domain; Region: HRDC; pfam00570 357348009781 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 357348009782 Transposase; Region: DDE_Tnp_ISL3; pfam01610 357348009783 Transposase; Region: HTH_Tnp_1; pfam01527 357348009784 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 357348009785 HTH-like domain; Region: HTH_21; pfam13276 357348009786 Integrase core domain; Region: rve; pfam00665 357348009787 Integrase core domain; Region: rve_3; pfam13683 357348009788 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 357348009789 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 357348009790 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 357348009791 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 357348009792 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 357348009793 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 357348009794 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 357348009795 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 357348009796 DNA binding site [nucleotide binding] 357348009797 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 357348009798 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 357348009799 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 357348009800 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 357348009801 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 357348009802 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 357348009803 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 357348009804 RPB3 interaction site [polypeptide binding]; other site 357348009805 RPB1 interaction site [polypeptide binding]; other site 357348009806 RPB11 interaction site [polypeptide binding]; other site 357348009807 RPB10 interaction site [polypeptide binding]; other site 357348009808 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 357348009809 peripheral dimer interface [polypeptide binding]; other site 357348009810 core dimer interface [polypeptide binding]; other site 357348009811 L10 interface [polypeptide binding]; other site 357348009812 L11 interface [polypeptide binding]; other site 357348009813 putative EF-Tu interaction site [polypeptide binding]; other site 357348009814 putative EF-G interaction site [polypeptide binding]; other site 357348009815 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 357348009816 23S rRNA interface [nucleotide binding]; other site 357348009817 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 357348009818 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 357348009819 mRNA/rRNA interface [nucleotide binding]; other site 357348009820 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 357348009821 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 357348009822 23S rRNA interface [nucleotide binding]; other site 357348009823 L7/L12 interface [polypeptide binding]; other site 357348009824 putative thiostrepton binding site; other site 357348009825 L25 interface [polypeptide binding]; other site 357348009826 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 357348009827 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 357348009828 putative homodimer interface [polypeptide binding]; other site 357348009829 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 357348009830 heterodimer interface [polypeptide binding]; other site 357348009831 homodimer interface [polypeptide binding]; other site 357348009832 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 357348009833 elongation factor Tu; Reviewed; Region: PRK00049 357348009834 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 357348009835 G1 box; other site 357348009836 GEF interaction site [polypeptide binding]; other site 357348009837 GTP/Mg2+ binding site [chemical binding]; other site 357348009838 Switch I region; other site 357348009839 G2 box; other site 357348009840 G3 box; other site 357348009841 Switch II region; other site 357348009842 G4 box; other site 357348009843 G5 box; other site 357348009844 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 357348009845 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 357348009846 Antibiotic Binding Site [chemical binding]; other site 357348009847 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 357348009848 active site 357348009849 catalytic triad [active] 357348009850 oxyanion hole [active] 357348009851 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 357348009852 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 357348009853 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 357348009854 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 357348009855 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 357348009856 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 357348009857 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 357348009858 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 357348009859 FAD binding pocket [chemical binding]; other site 357348009860 FAD binding motif [chemical binding]; other site 357348009861 phosphate binding motif [ion binding]; other site 357348009862 beta-alpha-beta structure motif; other site 357348009863 NAD(p) ribose binding residues [chemical binding]; other site 357348009864 NAD binding pocket [chemical binding]; other site 357348009865 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 357348009866 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 357348009867 catalytic loop [active] 357348009868 iron binding site [ion binding]; other site 357348009869 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 357348009870 Protein of unknown function; Region: DUF3658; pfam12395 357348009871 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 357348009872 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 357348009873 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 357348009874 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357348009875 Coenzyme A binding pocket [chemical binding]; other site 357348009876 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 357348009877 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 357348009878 putative DNA binding site [nucleotide binding]; other site 357348009879 putative Zn2+ binding site [ion binding]; other site 357348009880 AsnC family; Region: AsnC_trans_reg; pfam01037 357348009881 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 357348009882 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 357348009883 dimer interface [polypeptide binding]; other site 357348009884 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 357348009885 active site 357348009886 Fe binding site [ion binding]; other site 357348009887 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 357348009888 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 357348009889 dimer interface [polypeptide binding]; other site 357348009890 PYR/PP interface [polypeptide binding]; other site 357348009891 TPP binding site [chemical binding]; other site 357348009892 substrate binding site [chemical binding]; other site 357348009893 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 357348009894 TPP-binding site; other site 357348009895 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 357348009896 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 357348009897 Malic enzyme, N-terminal domain; Region: malic; pfam00390 357348009898 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 357348009899 putative NAD(P) binding site [chemical binding]; other site 357348009900 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 357348009901 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 357348009902 active site 357348009903 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 357348009904 substrate binding site [chemical binding]; other site 357348009905 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 357348009906 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 357348009907 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 357348009908 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 357348009909 Protein of unknown function (DUF2957); Region: DUF2957; pfam11170 357348009910 Protein of unknown function (DUF2957); Region: DUF2957; pfam11170 357348009911 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 357348009912 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357348009913 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348009914 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 357348009915 dimerization interface [polypeptide binding]; other site 357348009916 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 357348009917 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 357348009918 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 357348009919 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 357348009920 Uncharacterized conserved protein [Function unknown]; Region: COG1656 357348009921 Protein of unknown function DUF82; Region: DUF82; pfam01927 357348009922 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 357348009923 Spore germination protein; Region: Spore_permease; cl17796 357348009924 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 357348009925 HTH-like domain; Region: HTH_21; pfam13276 357348009926 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 357348009927 Integrase core domain; Region: rve; pfam00665 357348009928 Integrase core domain; Region: rve_3; pfam13683 357348009929 Transposase; Region: HTH_Tnp_1; pfam01527 357348009930 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 357348009931 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 357348009932 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 357348009933 haemagglutination activity domain; Region: Haemagg_act; pfam05860 357348009934 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 357348009935 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 357348009936 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 357348009937 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 357348009938 RES domain; Region: RES; pfam08808 357348009939 Transposase; Region: HTH_Tnp_1; pfam01527 357348009940 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 357348009941 HTH-like domain; Region: HTH_21; pfam13276 357348009942 Integrase core domain; Region: rve; pfam00665 357348009943 Integrase core domain; Region: rve_3; pfam13683 357348009944 Transposase; Region: HTH_Tnp_1; pfam01527 357348009945 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 357348009946 HTH-like domain; Region: HTH_21; pfam13276 357348009947 Integrase core domain; Region: rve; pfam00665 357348009948 Integrase core domain; Region: rve_3; pfam13683 357348009949 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 357348009950 putative active site [active] 357348009951 putative metal-binding site [ion binding]; other site 357348009952 Part of AAA domain; Region: AAA_19; pfam13245 357348009953 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 357348009954 Transposase domain (DUF772); Region: DUF772; pfam05598 357348009955 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 357348009956 DEAD-like helicases superfamily; Region: DEXDc; smart00487 357348009957 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 357348009958 ATP binding site [chemical binding]; other site 357348009959 putative Mg++ binding site [ion binding]; other site 357348009960 helicase superfamily c-terminal domain; Region: HELICc; smart00490 357348009961 nucleotide binding region [chemical binding]; other site 357348009962 ATP-binding site [chemical binding]; other site 357348009963 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 357348009964 active site 357348009965 DNA binding site [nucleotide binding] 357348009966 Int/Topo IB signature motif; other site 357348009967 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 357348009968 Cytochrome c; Region: Cytochrom_C; cl11414 357348009969 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 357348009970 BON domain; Region: BON; pfam04972 357348009971 BON domain; Region: BON; pfam04972 357348009972 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 357348009973 dimer interface [polypeptide binding]; other site 357348009974 active site 357348009975 hypothetical protein; Provisional; Region: PRK14673 357348009976 Predicted methyltransferases [General function prediction only]; Region: COG0313 357348009977 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 357348009978 putative SAM binding site [chemical binding]; other site 357348009979 putative homodimer interface [polypeptide binding]; other site 357348009980 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 357348009981 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 357348009982 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 357348009983 active site 357348009984 catalytic site [active] 357348009985 substrate binding site [chemical binding]; other site 357348009986 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 357348009987 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 357348009988 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 357348009989 putative DNA binding site [nucleotide binding]; other site 357348009990 putative Zn2+ binding site [ion binding]; other site 357348009991 AsnC family; Region: AsnC_trans_reg; pfam01037 357348009992 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 357348009993 Cation efflux family; Region: Cation_efflux; pfam01545 357348009994 H-NS histone family; Region: Histone_HNS; pfam00816 357348009995 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 357348009996 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 357348009997 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 357348009998 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 357348009999 dimerization interface [polypeptide binding]; other site 357348010000 ligand binding site [chemical binding]; other site 357348010001 Nitronate monooxygenase; Region: NMO; pfam03060 357348010002 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 357348010003 FMN binding site [chemical binding]; other site 357348010004 substrate binding site [chemical binding]; other site 357348010005 putative catalytic residue [active] 357348010006 Dienelactone hydrolase family; Region: DLH; pfam01738 357348010007 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 357348010008 Amidase; Region: Amidase; cl11426 357348010009 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 357348010010 FAD binding site [chemical binding]; other site 357348010011 Predicted membrane protein [Function unknown]; Region: COG1950 357348010012 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 357348010013 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 357348010014 homotetramer interface [polypeptide binding]; other site 357348010015 ligand binding site [chemical binding]; other site 357348010016 catalytic site [active] 357348010017 NAD binding site [chemical binding]; other site 357348010018 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 357348010019 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 357348010020 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 357348010021 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 357348010022 DNA binding residues [nucleotide binding] 357348010023 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 357348010024 flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14722 357348010025 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 357348010026 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 357348010027 FHIPEP family; Region: FHIPEP; pfam00771 357348010028 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 357348010029 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 357348010030 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 357348010031 dimer interface [polypeptide binding]; other site 357348010032 Protein of unknown function (DUF3443); Region: DUF3443; pfam11925 357348010033 Protein of unknown function (DUF2844); Region: DUF2844; pfam11005 357348010034 chemotaxis regulator CheZ; Provisional; Region: PRK11166 357348010035 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 357348010036 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348010037 active site 357348010038 phosphorylation site [posttranslational modification] 357348010039 intermolecular recognition site; other site 357348010040 dimerization interface [polypeptide binding]; other site 357348010041 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 357348010042 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348010043 active site 357348010044 phosphorylation site [posttranslational modification] 357348010045 intermolecular recognition site; other site 357348010046 dimerization interface [polypeptide binding]; other site 357348010047 CheB methylesterase; Region: CheB_methylest; pfam01339 357348010048 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13489 357348010049 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 357348010050 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 357348010051 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357348010052 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 357348010053 dimer interface [polypeptide binding]; other site 357348010054 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 357348010055 dimerization interface [polypeptide binding]; other site 357348010056 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 357348010057 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 357348010058 dimer interface [polypeptide binding]; other site 357348010059 putative CheW interface [polypeptide binding]; other site 357348010060 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 357348010061 putative CheA interaction surface; other site 357348010062 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 357348010063 putative binding surface; other site 357348010064 active site 357348010065 CheY binding; Region: CheY-binding; pfam09078 357348010066 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 357348010067 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357348010068 ATP binding site [chemical binding]; other site 357348010069 Mg2+ binding site [ion binding]; other site 357348010070 G-X-G motif; other site 357348010071 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 357348010072 Response regulator receiver domain; Region: Response_reg; pfam00072 357348010073 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348010074 active site 357348010075 phosphorylation site [posttranslational modification] 357348010076 intermolecular recognition site; other site 357348010077 dimerization interface [polypeptide binding]; other site 357348010078 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 357348010079 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 357348010080 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 357348010081 ligand binding site [chemical binding]; other site 357348010082 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 357348010083 flagellar motor protein MotA; Validated; Region: PRK09110 357348010084 transcriptional activator FlhC; Provisional; Region: PRK12722 357348010085 transcriptional activator FlhD; Provisional; Region: PRK02909 357348010086 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357348010087 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 357348010088 putative ADP-binding pocket [chemical binding]; other site 357348010089 H-NS histone family; Region: Histone_HNS; pfam00816 357348010090 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 357348010091 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 357348010092 amphipathic channel; other site 357348010093 Asn-Pro-Ala signature motifs; other site 357348010094 putative hydrolase; Provisional; Region: PRK10976 357348010095 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 357348010096 active site 357348010097 motif I; other site 357348010098 motif II; other site 357348010099 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 357348010100 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 357348010101 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 357348010102 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 357348010103 flagellin; Reviewed; Region: PRK08869 357348010104 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 357348010105 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 357348010106 flagellar capping protein; Reviewed; Region: fliD; PRK08032 357348010107 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 357348010108 Tetratricopeptide repeat; Region: TPR_16; pfam13432 357348010109 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357348010110 TPR motif; other site 357348010111 binding surface 357348010112 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357348010113 binding surface 357348010114 TPR motif; other site 357348010115 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 357348010116 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357348010117 TPR motif; other site 357348010118 binding surface 357348010119 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 357348010120 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 357348010121 inhibitor-cofactor binding pocket; inhibition site 357348010122 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348010123 catalytic residue [active] 357348010124 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 357348010125 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 357348010126 dimer interface [polypeptide binding]; other site 357348010127 active site 357348010128 CoA binding pocket [chemical binding]; other site 357348010129 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 357348010130 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 357348010131 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 357348010132 dimer interface [polypeptide binding]; other site 357348010133 active site 357348010134 CoA binding pocket [chemical binding]; other site 357348010135 short chain dehydrogenase; Provisional; Region: PRK06500 357348010136 classical (c) SDRs; Region: SDR_c; cd05233 357348010137 NAD(P) binding site [chemical binding]; other site 357348010138 active site 357348010139 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 357348010140 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 357348010141 putative trimer interface [polypeptide binding]; other site 357348010142 putative CoA binding site [chemical binding]; other site 357348010143 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 357348010144 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 357348010145 [2Fe-2S] cluster binding site [ion binding]; other site 357348010146 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 357348010147 alpha subunit interface [polypeptide binding]; other site 357348010148 active site 357348010149 substrate binding site [chemical binding]; other site 357348010150 Fe binding site [ion binding]; other site 357348010151 Methyltransferase domain; Region: Methyltransf_23; pfam13489 357348010152 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 357348010153 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 357348010154 acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397 357348010155 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4380 357348010156 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259 357348010157 Uncharacterized protein involved in formation of curli polymers [Cell envelope biogenesis, outer membrane]; Region: CsgG; COG1462 357348010158 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 357348010159 Cache domain; Region: Cache_1; pfam02743 357348010160 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 357348010161 dimerization interface [polypeptide binding]; other site 357348010162 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 357348010163 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 357348010164 dimer interface [polypeptide binding]; other site 357348010165 putative CheW interface [polypeptide binding]; other site 357348010166 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 357348010167 FAD binding domain; Region: FAD_binding_4; pfam01565 357348010168 Berberine and berberine like; Region: BBE; pfam08031 357348010169 Chitin binding domain; Region: Chitin_bind_3; pfam03067 357348010170 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 357348010171 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 357348010172 Transposase domain (DUF772); Region: DUF772; pfam05598 357348010173 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 357348010174 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 357348010175 active site 357348010176 DNA binding site [nucleotide binding] 357348010177 Int/Topo IB signature motif; other site 357348010178 Cytochrome c; Region: Cytochrom_C; cl11414 357348010179 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 357348010180 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 357348010181 Part of AAA domain; Region: AAA_19; pfam13245 357348010182 Family description; Region: UvrD_C_2; pfam13538 357348010183 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 357348010184 oxyanion hole [active] 357348010185 active site 357348010186 catalytic triad [active] 357348010187 putative oxidoreductase; Provisional; Region: PRK11579 357348010188 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 357348010189 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 357348010190 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 357348010191 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 357348010192 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 357348010193 lipoyl attachment site [posttranslational modification]; other site 357348010194 glycine dehydrogenase; Provisional; Region: PRK05367 357348010195 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 357348010196 tetramer interface [polypeptide binding]; other site 357348010197 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348010198 catalytic residue [active] 357348010199 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 357348010200 tetramer interface [polypeptide binding]; other site 357348010201 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348010202 catalytic residue [active] 357348010203 Alginate lyase; Region: Alginate_lyase; pfam05426 357348010204 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 357348010205 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 357348010206 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 357348010207 thiamine pyrophosphate protein; Validated; Region: PRK08199 357348010208 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 357348010209 PYR/PP interface [polypeptide binding]; other site 357348010210 dimer interface [polypeptide binding]; other site 357348010211 TPP binding site [chemical binding]; other site 357348010212 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 357348010213 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 357348010214 TPP-binding site [chemical binding]; other site 357348010215 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 357348010216 Helix-turn-helix domain; Region: HTH_18; pfam12833 357348010217 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 357348010218 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 357348010219 NAD(P) binding site [chemical binding]; other site 357348010220 catalytic residues [active] 357348010221 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 357348010222 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 357348010223 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 357348010224 ethanolamine permease; Region: 2A0305; TIGR00908 357348010225 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 357348010226 Acyltransferase family; Region: Acyl_transf_3; pfam01757 357348010227 Conserved TM helix; Region: TM_helix; pfam05552 357348010228 Conserved TM helix; Region: TM_helix; pfam05552 357348010229 Conserved TM helix; Region: TM_helix; pfam05552 357348010230 Double zinc ribbon; Region: DZR; pfam12773 357348010231 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 357348010232 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 357348010233 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 357348010234 Soluble P-type ATPase [General function prediction only]; Region: COG4087 357348010235 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 357348010236 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 357348010237 DNA binding residues [nucleotide binding] 357348010238 dimer interface [polypeptide binding]; other site 357348010239 putative metal binding site [ion binding]; other site 357348010240 Predicted transcriptional regulators [Transcription]; Region: COG1695 357348010241 Transcriptional regulator PadR-like family; Region: PadR; cl17335 357348010242 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 357348010243 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 357348010244 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 357348010245 substrate binding pocket [chemical binding]; other site 357348010246 membrane-bound complex binding site; other site 357348010247 hinge residues; other site 357348010248 putative aminotransferase; Provisional; Region: PRK12414 357348010249 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 357348010250 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348010251 homodimer interface [polypeptide binding]; other site 357348010252 catalytic residue [active] 357348010253 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 357348010254 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 357348010255 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 357348010256 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 357348010257 active site 357348010258 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 357348010259 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 357348010260 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 357348010261 acyl-activating enzyme (AAE) consensus motif; other site 357348010262 acyl-activating enzyme (AAE) consensus motif; other site 357348010263 putative AMP binding site [chemical binding]; other site 357348010264 putative active site [active] 357348010265 putative CoA binding site [chemical binding]; other site 357348010266 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 357348010267 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 357348010268 dimerization interface [polypeptide binding]; other site 357348010269 ligand binding site [chemical binding]; other site 357348010270 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 357348010271 Predicted transcriptional regulator [Transcription]; Region: COG3905 357348010272 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 357348010273 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 357348010274 Glutamate binding site [chemical binding]; other site 357348010275 NAD binding site [chemical binding]; other site 357348010276 catalytic residues [active] 357348010277 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 357348010278 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 357348010279 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 357348010280 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 357348010281 ATP binding site [chemical binding]; other site 357348010282 putative Mg++ binding site [ion binding]; other site 357348010283 nucleotide binding region [chemical binding]; other site 357348010284 helicase superfamily c-terminal domain; Region: HELICc; smart00490 357348010285 ATP-binding site [chemical binding]; other site 357348010286 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 357348010287 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 357348010288 substrate binding site [chemical binding]; other site 357348010289 active site 357348010290 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 357348010291 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 357348010292 substrate binding pocket [chemical binding]; other site 357348010293 membrane-bound complex binding site; other site 357348010294 hinge residues; other site 357348010295 CoA binding domain; Region: CoA_binding; cl17356 357348010296 AMP-binding domain protein; Validated; Region: PRK08315 357348010297 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 357348010298 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 357348010299 acyl-activating enzyme (AAE) consensus motif; other site 357348010300 putative AMP binding site [chemical binding]; other site 357348010301 putative active site [active] 357348010302 putative CoA binding site [chemical binding]; other site 357348010303 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 357348010304 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 357348010305 gamma subunit interface [polypeptide binding]; other site 357348010306 epsilon subunit interface [polypeptide binding]; other site 357348010307 LBP interface [polypeptide binding]; other site 357348010308 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 357348010309 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 357348010310 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 357348010311 alpha subunit interaction interface [polypeptide binding]; other site 357348010312 Walker A motif; other site 357348010313 ATP binding site [chemical binding]; other site 357348010314 Walker B motif; other site 357348010315 inhibitor binding site; inhibition site 357348010316 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 357348010317 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 357348010318 core domain interface [polypeptide binding]; other site 357348010319 delta subunit interface [polypeptide binding]; other site 357348010320 epsilon subunit interface [polypeptide binding]; other site 357348010321 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 357348010322 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 357348010323 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 357348010324 beta subunit interaction interface [polypeptide binding]; other site 357348010325 Walker A motif; other site 357348010326 ATP binding site [chemical binding]; other site 357348010327 Walker B motif; other site 357348010328 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 357348010329 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 357348010330 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 357348010331 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 357348010332 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 357348010333 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 357348010334 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 357348010335 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 357348010336 ATP synthase I chain; Region: ATP_synt_I; cl09170 357348010337 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 357348010338 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 357348010339 transmembrane helices; other site 357348010340 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 357348010341 ParB-like nuclease domain; Region: ParBc; pfam02195 357348010342 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 357348010343 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 357348010344 P-loop; other site 357348010345 Magnesium ion binding site [ion binding]; other site 357348010346 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 357348010347 Magnesium ion binding site [ion binding]; other site 357348010348 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 357348010349 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 357348010350 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 357348010351 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 357348010352 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 357348010353 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 357348010354 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 357348010355 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 357348010356 Walker A/P-loop; other site 357348010357 ATP binding site [chemical binding]; other site 357348010358 Q-loop/lid; other site 357348010359 ABC transporter signature motif; other site 357348010360 Walker B; other site 357348010361 D-loop; other site 357348010362 H-loop/switch region; other site 357348010363 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 357348010364 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 357348010365 TM-ABC transporter signature motif; other site 357348010366 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 357348010367 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 357348010368 Walker A/P-loop; other site 357348010369 ATP binding site [chemical binding]; other site 357348010370 Q-loop/lid; other site 357348010371 ABC transporter signature motif; other site 357348010372 Walker B; other site 357348010373 D-loop; other site 357348010374 H-loop/switch region; other site 357348010375 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 357348010376 TM-ABC transporter signature motif; other site 357348010377 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 357348010378 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 357348010379 putative ligand binding site [chemical binding]; other site 357348010380 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 357348010381 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 357348010382 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 357348010383 TM-ABC transporter signature motif; other site 357348010384 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 357348010385 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 357348010386 TM-ABC transporter signature motif; other site 357348010387 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 357348010388 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 357348010389 putative ligand binding site [chemical binding]; other site 357348010390 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 357348010391 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 357348010392 Walker A/P-loop; other site 357348010393 ATP binding site [chemical binding]; other site 357348010394 Q-loop/lid; other site 357348010395 ABC transporter signature motif; other site 357348010396 Walker B; other site 357348010397 D-loop; other site 357348010398 H-loop/switch region; other site 357348010399 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 357348010400 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 357348010401 Walker A/P-loop; other site 357348010402 ATP binding site [chemical binding]; other site 357348010403 Q-loop/lid; other site 357348010404 ABC transporter signature motif; other site 357348010405 Walker B; other site 357348010406 D-loop; other site 357348010407 H-loop/switch region; other site 357348010408 choline dehydrogenase; Validated; Region: PRK02106 357348010409 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 357348010410 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 357348010411 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 357348010412 tetrameric interface [polypeptide binding]; other site 357348010413 NAD binding site [chemical binding]; other site 357348010414 catalytic residues [active] 357348010415 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357348010416 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348010417 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 357348010418 dimerization interface [polypeptide binding]; other site 357348010419 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 357348010420 putative active site [active] 357348010421 putative metal binding residues [ion binding]; other site 357348010422 signature motif; other site 357348010423 putative triphosphate binding site [ion binding]; other site 357348010424 dimer interface [polypeptide binding]; other site 357348010425 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 357348010426 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 357348010427 putative DNA binding site [nucleotide binding]; other site 357348010428 putative Zn2+ binding site [ion binding]; other site 357348010429 AsnC family; Region: AsnC_trans_reg; pfam01037 357348010430 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 357348010431 cofactor binding site; other site 357348010432 metal binding site [ion binding]; metal-binding site 357348010433 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 357348010434 aromatic arch; other site 357348010435 DCoH dimer interaction site [polypeptide binding]; other site 357348010436 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 357348010437 DCoH tetramer interaction site [polypeptide binding]; other site 357348010438 substrate binding site [chemical binding]; other site 357348010439 Protein of unknown function (DUF3717); Region: DUF3717; pfam12512 357348010440 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 357348010441 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348010442 active site 357348010443 phosphorylation site [posttranslational modification] 357348010444 intermolecular recognition site; other site 357348010445 dimerization interface [polypeptide binding]; other site 357348010446 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357348010447 DNA binding site [nucleotide binding] 357348010448 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 357348010449 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357348010450 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357348010451 dimer interface [polypeptide binding]; other site 357348010452 phosphorylation site [posttranslational modification] 357348010453 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357348010454 ATP binding site [chemical binding]; other site 357348010455 Mg2+ binding site [ion binding]; other site 357348010456 G-X-G motif; other site 357348010457 Proteins containing SET domain [General function prediction only]; Region: COG2940 357348010458 SET domain; Region: SET; pfam00856 357348010459 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 357348010460 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 357348010461 active site 357348010462 FMN binding site [chemical binding]; other site 357348010463 substrate binding site [chemical binding]; other site 357348010464 homotetramer interface [polypeptide binding]; other site 357348010465 catalytic residue [active] 357348010466 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 357348010467 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 357348010468 catalytic triad [active] 357348010469 Transcriptional regulators [Transcription]; Region: MarR; COG1846 357348010470 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 357348010471 putative DNA binding site [nucleotide binding]; other site 357348010472 putative Zn2+ binding site [ion binding]; other site 357348010473 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 357348010474 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 357348010475 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 357348010476 active site 357348010477 Int/Topo IB signature motif; other site 357348010478 catalytic residues [active] 357348010479 DNA binding site [nucleotide binding] 357348010480 Protein of unknown function (DUF2471); Region: DUF2471; pfam10616 357348010481 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 357348010482 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 357348010483 non-specific DNA binding site [nucleotide binding]; other site 357348010484 salt bridge; other site 357348010485 sequence-specific DNA binding site [nucleotide binding]; other site 357348010486 Cupin domain; Region: Cupin_2; pfam07883 357348010487 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 357348010488 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 357348010489 substrate-cofactor binding pocket; other site 357348010490 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348010491 catalytic residue [active] 357348010492 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 357348010493 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 357348010494 NAD(P) binding site [chemical binding]; other site 357348010495 Uncharacterized conserved protein [Function unknown]; Region: COG2353 357348010496 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 357348010497 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 357348010498 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 357348010499 SnoaL-like domain; Region: SnoaL_2; pfam12680 357348010500 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_7; cd06910 357348010501 putative active site [active] 357348010502 Zn binding site [ion binding]; other site 357348010503 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 357348010504 tartrate dehydrogenase; Region: TTC; TIGR02089 357348010505 transcriptional activator TtdR; Provisional; Region: PRK09801 357348010506 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348010507 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 357348010508 putative effector binding pocket; other site 357348010509 putative dimerization interface [polypeptide binding]; other site 357348010510 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 357348010511 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 357348010512 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 357348010513 putative C-terminal domain interface [polypeptide binding]; other site 357348010514 putative GSH binding site (G-site) [chemical binding]; other site 357348010515 putative dimer interface [polypeptide binding]; other site 357348010516 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 357348010517 putative N-terminal domain interface [polypeptide binding]; other site 357348010518 putative dimer interface [polypeptide binding]; other site 357348010519 putative substrate binding pocket (H-site) [chemical binding]; other site 357348010520 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 357348010521 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 357348010522 nucleophile elbow; other site 357348010523 Patatin phospholipase; Region: DUF3734; pfam12536 357348010524 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK13394 357348010525 classical (c) SDRs; Region: SDR_c; cd05233 357348010526 NAD(P) binding site [chemical binding]; other site 357348010527 active site 357348010528 acetoacetate decarboxylase; Provisional; Region: PRK02265 357348010529 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 357348010530 active site 357348010531 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 357348010532 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 357348010533 FAD binding pocket [chemical binding]; other site 357348010534 FAD binding motif [chemical binding]; other site 357348010535 phosphate binding motif [ion binding]; other site 357348010536 NAD binding pocket [chemical binding]; other site 357348010537 Predicted transcriptional regulators [Transcription]; Region: COG1695 357348010538 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 357348010539 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 357348010540 Cytochrome P450; Region: p450; cl12078 357348010541 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 357348010542 Protein of unknown function (DUF692); Region: DUF692; cl01263 357348010543 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 357348010544 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 357348010545 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 357348010546 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 357348010547 FeS/SAM binding site; other site 357348010548 Methyltransferase domain; Region: Methyltransf_31; pfam13847 357348010549 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357348010550 S-adenosylmethionine binding site [chemical binding]; other site 357348010551 Lysine efflux permease [General function prediction only]; Region: COG1279 357348010552 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 357348010553 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348010554 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 357348010555 dimerization interface [polypeptide binding]; other site 357348010556 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 357348010557 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 357348010558 ligand binding site [chemical binding]; other site 357348010559 flexible hinge region; other site 357348010560 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 357348010561 putative switch regulator; other site 357348010562 non-specific DNA interactions [nucleotide binding]; other site 357348010563 DNA binding site [nucleotide binding] 357348010564 sequence specific DNA binding site [nucleotide binding]; other site 357348010565 putative cAMP binding site [chemical binding]; other site 357348010566 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 357348010567 Ligand Binding Site [chemical binding]; other site 357348010568 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 357348010569 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 357348010570 dimer interface [polypeptide binding]; other site 357348010571 NADP binding site [chemical binding]; other site 357348010572 catalytic residues [active] 357348010573 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 357348010574 Strictosidine synthase; Region: Str_synth; pfam03088 357348010575 Protein of unknown function (DUF3005); Region: DUF3005; pfam11448 357348010576 Transcriptional activator HlyU; Region: HlyU; cl02273 357348010577 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 357348010578 serine O-acetyltransferase; Region: cysE; TIGR01172 357348010579 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 357348010580 trimer interface [polypeptide binding]; other site 357348010581 active site 357348010582 substrate binding site [chemical binding]; other site 357348010583 CoA binding site [chemical binding]; other site 357348010584 short chain dehydrogenase; Provisional; Region: PRK09134 357348010585 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357348010586 NAD(P) binding site [chemical binding]; other site 357348010587 active site 357348010588 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 357348010589 GTP cyclohydrolase I; Provisional; Region: PLN03044 357348010590 active site 357348010591 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357348010592 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348010593 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 357348010594 substrate binding pocket [chemical binding]; other site 357348010595 dimerization interface [polypeptide binding]; other site 357348010596 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 357348010597 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 357348010598 3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429 357348010599 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 357348010600 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 357348010601 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 357348010602 tetramer interface [polypeptide binding]; other site 357348010603 active site 357348010604 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 357348010605 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 357348010606 benzoate transport; Region: 2A0115; TIGR00895 357348010607 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348010608 putative substrate translocation pore; other site 357348010609 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348010610 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 357348010611 Uncharacterized conserved protein [Function unknown]; Region: COG3391 357348010612 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 357348010613 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 357348010614 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 357348010615 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 357348010616 Chromate resistance exported protein; Region: Chrome_Resist; pfam09828 357348010617 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 357348010618 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 357348010619 Chromate transporter; Region: Chromate_transp; pfam02417 357348010620 Chromate resistance exported protein; Region: Chrome_Resist; pfam09828 357348010621 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 357348010622 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 357348010623 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 357348010624 RNA polymerase sigma factor; Provisional; Region: PRK11922 357348010625 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 357348010626 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 357348010627 DNA binding residues [nucleotide binding] 357348010628 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 357348010629 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 357348010630 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 357348010631 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357348010632 Walker A/P-loop; other site 357348010633 ATP binding site [chemical binding]; other site 357348010634 Q-loop/lid; other site 357348010635 ABC transporter signature motif; other site 357348010636 Walker B; other site 357348010637 D-loop; other site 357348010638 H-loop/switch region; other site 357348010639 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357348010640 Walker A/P-loop; other site 357348010641 ATP binding site [chemical binding]; other site 357348010642 Q-loop/lid; other site 357348010643 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 357348010644 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 357348010645 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 357348010646 H-NS histone family; Region: Histone_HNS; pfam00816 357348010647 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 357348010648 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 357348010649 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348010650 putative substrate translocation pore; other site 357348010651 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 357348010652 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357348010653 dimer interface [polypeptide binding]; other site 357348010654 phosphorylation site [posttranslational modification] 357348010655 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357348010656 ATP binding site [chemical binding]; other site 357348010657 Mg2+ binding site [ion binding]; other site 357348010658 G-X-G motif; other site 357348010659 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 357348010660 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348010661 active site 357348010662 phosphorylation site [posttranslational modification] 357348010663 intermolecular recognition site; other site 357348010664 dimerization interface [polypeptide binding]; other site 357348010665 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357348010666 Walker A motif; other site 357348010667 ATP binding site [chemical binding]; other site 357348010668 Walker B motif; other site 357348010669 arginine finger; other site 357348010670 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 357348010671 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 357348010672 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357348010673 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357348010674 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 357348010675 Phosphoesterase family; Region: Phosphoesterase; pfam04185 357348010676 Domain of unknown function (DUF756); Region: DUF756; pfam05506 357348010677 Domain of unknown function (DUF756); Region: DUF756; pfam05506 357348010678 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 357348010679 RNA polymerase sigma factor; Reviewed; Region: PRK12527 357348010680 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 357348010681 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357348010682 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348010683 dimer interface [polypeptide binding]; other site 357348010684 conserved gate region; other site 357348010685 putative PBP binding loops; other site 357348010686 ABC-ATPase subunit interface; other site 357348010687 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 357348010688 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 357348010689 H-NS histone family; Region: Histone_HNS; pfam00816 357348010690 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 357348010691 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 357348010692 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 357348010693 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 357348010694 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 357348010695 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253 357348010696 Protein of unknown function (DUF3274); Region: DUF3274; pfam11678 357348010697 Protein of unknown function (DUF2875); Region: DUF2875; pfam11394 357348010698 Uncharacterized conserved protein [Function unknown]; Region: COG4104 357348010699 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 357348010700 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 357348010701 catalytic residues [active] 357348010702 Integral membrane protein (DUF2244); Region: DUF2244; pfam10003 357348010703 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 357348010704 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 357348010705 Subunit I/III interface [polypeptide binding]; other site 357348010706 D-pathway; other site 357348010707 Subunit I/VIIc interface [polypeptide binding]; other site 357348010708 Subunit I/IV interface [polypeptide binding]; other site 357348010709 Subunit I/II interface [polypeptide binding]; other site 357348010710 Low-spin heme (heme a) binding site [chemical binding]; other site 357348010711 Subunit I/VIIa interface [polypeptide binding]; other site 357348010712 Subunit I/VIa interface [polypeptide binding]; other site 357348010713 Dimer interface; other site 357348010714 Putative water exit pathway; other site 357348010715 Binuclear center (heme a3/CuB) [ion binding]; other site 357348010716 K-pathway; other site 357348010717 Subunit I/Vb interface [polypeptide binding]; other site 357348010718 Putative proton exit pathway; other site 357348010719 Subunit I/VIb interface; other site 357348010720 Subunit I/VIc interface [polypeptide binding]; other site 357348010721 Electron transfer pathway; other site 357348010722 Subunit I/VIIIb interface [polypeptide binding]; other site 357348010723 Subunit I/VIIb interface [polypeptide binding]; other site 357348010724 Haemagglutinin; Region: HIM; pfam05662 357348010725 YadA-like C-terminal region; Region: YadA; pfam03895 357348010726 PhoPQ-activated pathogenicity-related protein; Region: PhoPQ_related; cl01750 357348010727 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 357348010728 YfaZ precursor; Region: YfaZ; pfam07437 357348010729 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 357348010730 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 357348010731 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 357348010732 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 357348010733 PapC N-terminal domain; Region: PapC_N; pfam13954 357348010734 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 357348010735 PapC C-terminal domain; Region: PapC_C; pfam13953 357348010736 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 357348010737 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 357348010738 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 357348010739 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 357348010740 ligand binding site [chemical binding]; other site 357348010741 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 357348010742 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 357348010743 Protein of unknown function (DUF877); Region: DUF877; pfam05943 357348010744 Protein of unknown function (DUF796); Region: DUF796; pfam05638 357348010745 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 357348010746 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 357348010747 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 357348010748 hypothetical protein; Provisional; Region: PRK08126 357348010749 type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349 357348010750 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 357348010751 ligand binding site [chemical binding]; other site 357348010752 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 357348010753 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 357348010754 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 357348010755 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 357348010756 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 357348010757 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 357348010758 PAAR motif; Region: PAAR_motif; pfam05488 357348010759 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 357348010760 RHS Repeat; Region: RHS_repeat; cl11982 357348010761 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 357348010762 RHS Repeat; Region: RHS_repeat; cl11982 357348010763 RHS protein; Region: RHS; pfam03527 357348010764 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 357348010765 Fimbrial protein; Region: Fimbrial; pfam00419 357348010766 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 357348010767 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 357348010768 type VI secretion protein, VC_A0111 family; Region: VI_chp_1; TIGR03347 357348010769 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 357348010770 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 357348010771 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 357348010772 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 357348010773 ImpE protein; Region: ImpE; pfam07024 357348010774 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 357348010775 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357348010776 Walker A motif; other site 357348010777 ATP binding site [chemical binding]; other site 357348010778 Walker B motif; other site 357348010779 arginine finger; other site 357348010780 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357348010781 Walker A motif; other site 357348010782 ATP binding site [chemical binding]; other site 357348010783 Walker B motif; other site 357348010784 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 357348010785 Cache domain; Region: Cache_1; pfam02743 357348010786 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357348010787 dimer interface [polypeptide binding]; other site 357348010788 phosphorylation site [posttranslational modification] 357348010789 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357348010790 ATP binding site [chemical binding]; other site 357348010791 Mg2+ binding site [ion binding]; other site 357348010792 G-X-G motif; other site 357348010793 Response regulator receiver domain; Region: Response_reg; pfam00072 357348010794 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348010795 active site 357348010796 phosphorylation site [posttranslational modification] 357348010797 intermolecular recognition site; other site 357348010798 dimerization interface [polypeptide binding]; other site 357348010799 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 357348010800 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348010801 active site 357348010802 phosphorylation site [posttranslational modification] 357348010803 intermolecular recognition site; other site 357348010804 dimerization interface [polypeptide binding]; other site 357348010805 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 357348010806 DNA binding residues [nucleotide binding] 357348010807 dimerization interface [polypeptide binding]; other site 357348010808 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 357348010809 PapC N-terminal domain; Region: PapC_N; pfam13954 357348010810 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 357348010811 PapC C-terminal domain; Region: PapC_C; pfam13953 357348010812 putative fimbrial chaperone protein; Provisional; Region: PRK09918 357348010813 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 357348010814 Protein of unknown function (DUF1120); Region: DUF1120; cl05856 357348010815 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 357348010816 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348010817 active site 357348010818 phosphorylation site [posttranslational modification] 357348010819 intermolecular recognition site; other site 357348010820 dimerization interface [polypeptide binding]; other site 357348010821 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 357348010822 DNA binding residues [nucleotide binding] 357348010823 dimerization interface [polypeptide binding]; other site 357348010824 H-NS histone family; Region: Histone_HNS; pfam00816 357348010825 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 357348010826 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 357348010827 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348010828 putative substrate translocation pore; other site 357348010829 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 357348010830 pyruvate kinase; Provisional; Region: PRK06247 357348010831 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 357348010832 domain interfaces; other site 357348010833 active site 357348010834 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 357348010835 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 357348010836 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 357348010837 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 357348010838 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 357348010839 acyl-activating enzyme (AAE) consensus motif; other site 357348010840 AMP binding site [chemical binding]; other site 357348010841 active site 357348010842 CoA binding site [chemical binding]; other site 357348010843 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 357348010844 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 357348010845 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 357348010846 extended (e) SDRs; Region: SDR_e; cd08946 357348010847 NAD(P) binding site [chemical binding]; other site 357348010848 active site 357348010849 substrate binding site [chemical binding]; other site 357348010850 SnoaL-like domain; Region: SnoaL_2; pfam12680 357348010851 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 357348010852 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357348010853 S-adenosylmethionine binding site [chemical binding]; other site 357348010854 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348010855 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 357348010856 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 357348010857 substrate binding pocket [chemical binding]; other site 357348010858 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 357348010859 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 357348010860 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 357348010861 metal binding site [ion binding]; metal-binding site 357348010862 active site 357348010863 I-site; other site 357348010864 mercuric reductase; Validated; Region: PRK06370 357348010865 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 357348010866 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 357348010867 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 357348010868 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 357348010869 putative ligand binding site [chemical binding]; other site 357348010870 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 357348010871 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 357348010872 TM-ABC transporter signature motif; other site 357348010873 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 357348010874 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 357348010875 Walker A/P-loop; other site 357348010876 ATP binding site [chemical binding]; other site 357348010877 Q-loop/lid; other site 357348010878 ABC transporter signature motif; other site 357348010879 Walker B; other site 357348010880 D-loop; other site 357348010881 H-loop/switch region; other site 357348010882 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 357348010883 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 357348010884 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 357348010885 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 357348010886 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430 357348010887 Domain interface; other site 357348010888 glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535 357348010889 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 357348010890 Alpha-amylase, C-terminal CBM20 (carbohydrate-binding module, family 20) domain. This domain is found in several bacterial and fungal alpha-amylases including the maltopentaose-forming amylases (G5-amylases). Most alpha-amylases have, in addition to the...; Region: CBM20_alpha_amylase; cd05808 357348010891 starch-binding site 2 [chemical binding]; other site 357348010892 starch-binding site 1 [chemical binding]; other site 357348010893 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 357348010894 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 357348010895 ATP binding site [chemical binding]; other site 357348010896 Mg++ binding site [ion binding]; other site 357348010897 motif III; other site 357348010898 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 357348010899 nucleotide binding region [chemical binding]; other site 357348010900 ATP-binding site [chemical binding]; other site 357348010901 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 357348010902 putative RNA binding site [nucleotide binding]; other site 357348010903 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 357348010904 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348010905 metabolite-proton symporter; Region: 2A0106; TIGR00883 357348010906 putative substrate translocation pore; other site 357348010907 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 357348010908 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 357348010909 metal binding site [ion binding]; metal-binding site 357348010910 putative dimer interface [polypeptide binding]; other site 357348010911 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 357348010912 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348010913 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 357348010914 dimerization interface [polypeptide binding]; other site 357348010915 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 357348010916 Fatty acid desaturase protein family subgroup, a delta-12 acyl-lipid desaturase-like, DesA-like, yet uncharacterized subgroup of membrane fatty acid desaturase proteins found in alpha-, beta-, and gamma-proteobacteria. Sequences of this domain family...; Region: DesA_FADS-like; cd03509 357348010917 putative di-iron ligands [ion binding]; other site 357348010918 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 357348010919 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 357348010920 substrate binding pocket [chemical binding]; other site 357348010921 membrane-bound complex binding site; other site 357348010922 hinge residues; other site 357348010923 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 357348010924 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 357348010925 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357348010926 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348010927 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 357348010928 dimerization interface [polypeptide binding]; other site 357348010929 short chain dehydrogenase; Provisional; Region: PRK07023 357348010930 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357348010931 NAD(P) binding site [chemical binding]; other site 357348010932 active site 357348010933 SnoaL-like domain; Region: SnoaL_2; pfam12680 357348010934 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 357348010935 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 357348010936 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 357348010937 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561 357348010938 Pyoverdine/dityrosine biosynthesis protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: DIT1; COG3207 357348010939 Pyoverdine/dityrosine biosynthesis protein; Region: DIT1_PvcA; pfam05141 357348010940 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 357348010941 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 357348010942 substrate binding pocket [chemical binding]; other site 357348010943 active site 357348010944 iron coordination sites [ion binding]; other site 357348010945 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 357348010946 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 357348010947 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 357348010948 active site 357348010949 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 357348010950 dimer interface [polypeptide binding]; other site 357348010951 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 357348010952 Ligand Binding Site [chemical binding]; other site 357348010953 Molecular Tunnel; other site 357348010954 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 357348010955 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 357348010956 NADP binding site [chemical binding]; other site 357348010957 dimer interface [polypeptide binding]; other site 357348010958 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 357348010959 putative active site [active] 357348010960 putative metal binding site [ion binding]; other site 357348010961 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357348010962 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348010963 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 357348010964 putative effector binding pocket; other site 357348010965 dimerization interface [polypeptide binding]; other site 357348010966 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 357348010967 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 357348010968 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 357348010969 hypothetical protein; Provisional; Region: PRK08126 357348010970 type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349 357348010971 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 357348010972 ligand binding site [chemical binding]; other site 357348010973 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 357348010974 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 357348010975 type VI secretion lipoprotein, VC_A0113 family; Region: VI_chp_3; TIGR03352 357348010976 Protein of unknown function (DUF796); Region: DUF796; pfam05638 357348010977 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 357348010978 Protein of unknown function (DUF877); Region: DUF877; pfam05943 357348010979 Protein of unknown function (DUF770); Region: DUF770; pfam05591 357348010980 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357348010981 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 357348010982 Walker A motif; other site 357348010983 ATP binding site [chemical binding]; other site 357348010984 Walker B motif; other site 357348010985 arginine finger; other site 357348010986 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357348010987 Walker A motif; other site 357348010988 ATP binding site [chemical binding]; other site 357348010989 Walker B motif; other site 357348010990 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 357348010991 ImpE protein; Region: ImpE; pfam07024 357348010992 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 357348010993 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 357348010994 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 357348010995 type VI secretion protein, VC_A0111 family; Region: VI_chp_1; TIGR03347 357348010996 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 357348010997 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 357348010998 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 357348010999 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 357348011000 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 357348011001 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 357348011002 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 357348011003 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 357348011004 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 357348011005 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 357348011006 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 357348011007 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 357348011008 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 357348011009 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 357348011010 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 357348011011 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 357348011012 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 357348011013 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 357348011014 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 357348011015 Protein of unknown function (DUF3540); Region: DUF3540; pfam12059 357348011016 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 357348011017 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 357348011018 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357348011019 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348011020 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_3; cd08461 357348011021 putative substrate binding pocket [chemical binding]; other site 357348011022 putative dimerization interface [polypeptide binding]; other site 357348011023 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 357348011024 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 357348011025 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 357348011026 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357348011027 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084 357348011028 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 357348011029 homodimer interface [polypeptide binding]; other site 357348011030 substrate-cofactor binding pocket; other site 357348011031 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348011032 catalytic residue [active] 357348011033 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 357348011034 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 357348011035 dimer interface [polypeptide binding]; other site 357348011036 putative metal binding site [ion binding]; other site 357348011037 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 357348011038 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 357348011039 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 357348011040 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 357348011041 acetyl-CoA carboxylase biotin carboxylase subunit; Provisional; Region: PRK12833 357348011042 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 357348011043 ATP-grasp domain; Region: ATP-grasp_4; cl17255 357348011044 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 357348011045 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 357348011046 carboxyltransferase (CT) interaction site; other site 357348011047 biotinylation site [posttranslational modification]; other site 357348011048 uncharacterized proteins similar to the Aspergillus nidulans lactam utilization protein LamB; Region: LamB_YcsF_like_2; cd11664 357348011049 putative active site [active] 357348011050 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357348011051 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348011052 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 357348011053 putative substrate binding pocket [chemical binding]; other site 357348011054 dimerization interface [polypeptide binding]; other site 357348011055 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 357348011056 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 357348011057 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 357348011058 active site 357348011059 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 357348011060 TAP-like protein; Region: Abhydrolase_4; pfam08386 357348011061 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357348011062 S-adenosylmethionine binding site [chemical binding]; other site 357348011063 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 357348011064 dimerization interface [polypeptide binding]; other site 357348011065 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 357348011066 dimer interface [polypeptide binding]; other site 357348011067 putative CheW interface [polypeptide binding]; other site 357348011068 Propionate catabolism activator; Region: PrpR_N; pfam06506 357348011069 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 357348011070 putative active site [active] 357348011071 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357348011072 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 357348011073 Walker A motif; other site 357348011074 ATP binding site [chemical binding]; other site 357348011075 Walker B motif; other site 357348011076 arginine finger; other site 357348011077 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 357348011078 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 357348011079 tetramer interface [polypeptide binding]; other site 357348011080 active site 357348011081 Mg2+/Mn2+ binding site [ion binding]; other site 357348011082 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 357348011083 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 357348011084 dimer interface [polypeptide binding]; other site 357348011085 active site 357348011086 citrylCoA binding site [chemical binding]; other site 357348011087 oxalacetate/citrate binding site [chemical binding]; other site 357348011088 coenzyme A binding site [chemical binding]; other site 357348011089 catalytic triad [active] 357348011090 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 357348011091 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 357348011092 substrate binding site [chemical binding]; other site 357348011093 ligand binding site [chemical binding]; other site 357348011094 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 357348011095 substrate binding site [chemical binding]; other site 357348011096 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 357348011097 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 357348011098 CoenzymeA binding site [chemical binding]; other site 357348011099 subunit interaction site [polypeptide binding]; other site 357348011100 PHB binding site; other site 357348011101 Domain of unknown function (DUF1843); Region: DUF1843; pfam08898 357348011102 Domain of unknown function (DUF1842); Region: DUF1842; pfam08896 357348011103 Domain of unknown function (DUF1843); Region: DUF1843; pfam08898 357348011104 Domain of unknown function (DUF1842); Region: DUF1842; pfam08896 357348011105 Domain of unknown function (DUF1843); Region: DUF1843; pfam08898 357348011106 Y_X(10)_GDL-associated radical SAM protein; Region: rad_SAM_trio; TIGR03913 357348011107 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 357348011108 FeS/SAM binding site; other site 357348011109 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 357348011110 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 357348011111 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 357348011112 dimer interface [polypeptide binding]; other site 357348011113 ligand binding site [chemical binding]; other site 357348011114 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 357348011115 dimer interface [polypeptide binding]; other site 357348011116 putative CheW interface [polypeptide binding]; other site 357348011117 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348011118 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 357348011119 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 357348011120 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348011121 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 357348011122 dimerization interface [polypeptide binding]; other site 357348011123 substrate binding pocket [chemical binding]; other site 357348011124 dimerization interface [polypeptide binding]; other site 357348011125 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 357348011126 putative active cleft [active] 357348011127 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 357348011128 MgtC family; Region: MgtC; pfam02308 357348011129 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 357348011130 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357348011131 Coenzyme A binding pocket [chemical binding]; other site 357348011132 Protein of unknown function (DUF4087); Region: DUF4087; pfam13316 357348011133 Heavy-metal-associated domain; Region: HMA; pfam00403 357348011134 metal-binding site [ion binding] 357348011135 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 357348011136 metal-binding site [ion binding] 357348011137 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 357348011138 metal-binding site [ion binding] 357348011139 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 357348011140 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 357348011141 metal-binding site [ion binding] 357348011142 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 357348011143 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 357348011144 Uncharacterized conserved protein [Function unknown]; Region: COG5361 357348011145 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 357348011146 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 357348011147 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 357348011148 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 357348011149 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 357348011150 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 357348011151 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 357348011152 Sulfatase; Region: Sulfatase; cl17466 357348011153 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 357348011154 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 357348011155 active site 357348011156 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 357348011157 active site lid residues [active] 357348011158 substrate binding pocket [chemical binding]; other site 357348011159 catalytic residues [active] 357348011160 substrate-Mg2+ binding site; other site 357348011161 aspartate-rich region 1; other site 357348011162 aspartate-rich region 2; other site 357348011163 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 357348011164 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 357348011165 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 357348011166 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 357348011167 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 357348011168 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 357348011169 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 357348011170 tetramer interface [polypeptide binding]; other site 357348011171 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348011172 catalytic residue [active] 357348011173 chromosome replication initiation inhibitor protein; Provisional; Region: PRK13348 357348011174 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348011175 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 357348011176 putative dimerization interface [polypeptide binding]; other site 357348011177 Transglycosylase; Region: Transgly; pfam00912 357348011178 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 357348011179 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 357348011180 Predicted membrane protein [Function unknown]; Region: COG2860 357348011181 UPF0126 domain; Region: UPF0126; pfam03458 357348011182 UPF0126 domain; Region: UPF0126; pfam03458 357348011183 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13547 357348011184 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 357348011185 Walker A/P-loop; other site 357348011186 ATP binding site [chemical binding]; other site 357348011187 Q-loop/lid; other site 357348011188 ABC transporter signature motif; other site 357348011189 Walker B; other site 357348011190 D-loop; other site 357348011191 H-loop/switch region; other site 357348011192 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 357348011193 putative PBP binding regions; other site 357348011194 ABC-ATPase subunit interface; other site 357348011195 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 357348011196 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 357348011197 intersubunit interface [polypeptide binding]; other site 357348011198 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 357348011199 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 357348011200 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 357348011201 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 357348011202 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 357348011203 N-terminal plug; other site 357348011204 ligand-binding site [chemical binding]; other site 357348011205 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 357348011206 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348011207 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 357348011208 dimerization interface [polypeptide binding]; other site 357348011209 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348011210 dimer interface [polypeptide binding]; other site 357348011211 conserved gate region; other site 357348011212 putative PBP binding loops; other site 357348011213 ABC-ATPase subunit interface; other site 357348011214 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 357348011215 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 357348011216 Walker A/P-loop; other site 357348011217 ATP binding site [chemical binding]; other site 357348011218 Q-loop/lid; other site 357348011219 ABC transporter signature motif; other site 357348011220 Walker B; other site 357348011221 D-loop; other site 357348011222 H-loop/switch region; other site 357348011223 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 357348011224 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 357348011225 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348011226 dimer interface [polypeptide binding]; other site 357348011227 conserved gate region; other site 357348011228 putative PBP binding loops; other site 357348011229 ABC-ATPase subunit interface; other site 357348011230 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 357348011231 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 357348011232 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 357348011233 trimer interface [polypeptide binding]; other site 357348011234 eyelet of channel; other site 357348011235 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 357348011236 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 357348011237 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 357348011238 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 357348011239 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 357348011240 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 357348011241 Walker A/P-loop; other site 357348011242 ATP binding site [chemical binding]; other site 357348011243 Q-loop/lid; other site 357348011244 ABC transporter signature motif; other site 357348011245 Walker B; other site 357348011246 D-loop; other site 357348011247 H-loop/switch region; other site 357348011248 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 357348011249 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 357348011250 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 357348011251 TM-ABC transporter signature motif; other site 357348011252 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 357348011253 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 357348011254 putative ligand binding site [chemical binding]; other site 357348011255 short chain dehydrogenase; Provisional; Region: PRK06841 357348011256 classical (c) SDRs; Region: SDR_c; cd05233 357348011257 NAD(P) binding site [chemical binding]; other site 357348011258 active site 357348011259 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 357348011260 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH2; cd08256 357348011261 putative NAD(P) binding site [chemical binding]; other site 357348011262 catalytic Zn binding site [ion binding]; other site 357348011263 structural Zn binding site [ion binding]; other site 357348011264 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 357348011265 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 357348011266 DAK2 domain; Region: Dak2; cl03685 357348011267 Protein of unknown function (DUF2866); Region: DUF2866; pfam11065 357348011268 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 357348011269 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 357348011270 trimer interface [polypeptide binding]; other site 357348011271 eyelet of channel; other site 357348011272 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 357348011273 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 357348011274 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 357348011275 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 357348011276 active site 357348011277 Zn binding site [ion binding]; other site 357348011278 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 357348011279 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 357348011280 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 357348011281 substrate binding pocket [chemical binding]; other site 357348011282 membrane-bound complex binding site; other site 357348011283 hinge residues; other site 357348011284 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 357348011285 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348011286 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 357348011287 dimerization interface [polypeptide binding]; other site 357348011288 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 357348011289 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 357348011290 metal binding site [ion binding]; metal-binding site 357348011291 putative dimer interface [polypeptide binding]; other site 357348011292 metabolite-proton symporter; Region: 2A0106; TIGR00883 357348011293 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348011294 putative substrate translocation pore; other site 357348011295 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 357348011296 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 357348011297 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 357348011298 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 357348011299 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 357348011300 Bacterial transcriptional regulator; Region: IclR; pfam01614 357348011301 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 357348011302 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 357348011303 dimer interface [polypeptide binding]; other site 357348011304 active site 357348011305 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 357348011306 PAS domain; Region: PAS_9; pfam13426 357348011307 putative active site [active] 357348011308 heme pocket [chemical binding]; other site 357348011309 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 357348011310 dimer interface [polypeptide binding]; other site 357348011311 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 357348011312 putative CheW interface [polypeptide binding]; other site 357348011313 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 357348011314 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357348011315 S-adenosylmethionine binding site [chemical binding]; other site 357348011316 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 357348011317 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 357348011318 hydrophobic ligand binding site; other site 357348011319 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 357348011320 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 357348011321 iron-sulfur cluster [ion binding]; other site 357348011322 [2Fe-2S] cluster binding site [ion binding]; other site 357348011323 succinic semialdehyde dehydrogenase; Region: PLN02278 357348011324 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 357348011325 tetramerization interface [polypeptide binding]; other site 357348011326 NAD(P) binding site [chemical binding]; other site 357348011327 catalytic residues [active] 357348011328 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 357348011329 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 357348011330 inhibitor-cofactor binding pocket; inhibition site 357348011331 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348011332 catalytic residue [active] 357348011333 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 357348011334 DNA-binding site [nucleotide binding]; DNA binding site 357348011335 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 357348011336 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 357348011337 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348011338 homodimer interface [polypeptide binding]; other site 357348011339 catalytic residue [active] 357348011340 Predicted membrane protein [Function unknown]; Region: COG1288; cl17886 357348011341 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 357348011342 Transcriptional regulator [Transcription]; Region: IclR; COG1414 357348011343 Bacterial transcriptional regulator; Region: IclR; pfam01614 357348011344 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 357348011345 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 357348011346 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 357348011347 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 357348011348 EamA-like transporter family; Region: EamA; cl17759 357348011349 selenophosphate synthetase; Provisional; Region: PRK00943 357348011350 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 357348011351 dimerization interface [polypeptide binding]; other site 357348011352 putative ATP binding site [chemical binding]; other site 357348011353 Purine nucleoside permease (NUP); Region: NUP; pfam06516 357348011354 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 357348011355 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357348011356 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348011357 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 357348011358 putative effector binding pocket; other site 357348011359 putative dimerization interface [polypeptide binding]; other site 357348011360 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 357348011361 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 357348011362 substrate binding pocket [chemical binding]; other site 357348011363 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 357348011364 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 357348011365 HlyD family secretion protein; Region: HlyD_3; pfam13437 357348011366 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 357348011367 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 357348011368 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 357348011369 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 357348011370 Transcriptional regulators [Transcription]; Region: GntR; COG1802 357348011371 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 357348011372 DNA-binding site [nucleotide binding]; DNA binding site 357348011373 FCD domain; Region: FCD; pfam07729 357348011374 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357348011375 Coenzyme A binding pocket [chemical binding]; other site 357348011376 Membrane transport protein; Region: Mem_trans; cl09117 357348011377 acyl-CoA synthetase; Validated; Region: PRK05850 357348011378 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 357348011379 acyl-activating enzyme (AAE) consensus motif; other site 357348011380 active site 357348011381 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 357348011382 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 357348011383 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 357348011384 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 357348011385 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 357348011386 acyl-activating enzyme (AAE) consensus motif; other site 357348011387 AMP binding site [chemical binding]; other site 357348011388 active site 357348011389 CoA binding site [chemical binding]; other site 357348011390 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 357348011391 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 357348011392 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 357348011393 catalytic residue [active] 357348011394 Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882 357348011395 Ketol-acid reductoisomerase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvC; COG0059 357348011396 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 357348011397 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 357348011398 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 357348011399 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 357348011400 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 357348011401 active site 357348011402 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 357348011403 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 357348011404 putative NADP binding site [chemical binding]; other site 357348011405 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 357348011406 active site 357348011407 Methyltransferase domain; Region: Methyltransf_12; pfam08242 357348011408 Methyltransferase domain; Region: Methyltransf_23; pfam13489 357348011409 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 357348011410 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 357348011411 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 357348011412 active site 357348011413 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 357348011414 Condensation domain; Region: Condensation; pfam00668 357348011415 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 357348011416 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 357348011417 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 357348011418 thioester reductase domain; Region: Thioester-redct; TIGR01746 357348011419 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 357348011420 putative NAD(P) binding site [chemical binding]; other site 357348011421 active site 357348011422 putative substrate binding site [chemical binding]; other site 357348011423 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 357348011424 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 357348011425 tetrameric interface [polypeptide binding]; other site 357348011426 NAD binding site [chemical binding]; other site 357348011427 catalytic residues [active] 357348011428 substrate binding site [chemical binding]; other site 357348011429 hypothetical protein; Provisional; Region: PRK07036 357348011430 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 357348011431 inhibitor-cofactor binding pocket; inhibition site 357348011432 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348011433 catalytic residue [active] 357348011434 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 357348011435 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317 357348011436 Cysteine-rich motif following a subset of SET domains; Region: PostSET; smart00508 357348011437 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 357348011438 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 357348011439 AMP-binding enzyme; Region: AMP-binding; pfam00501 357348011440 acyl-activating enzyme (AAE) consensus motif; other site 357348011441 AMP binding site [chemical binding]; other site 357348011442 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 357348011443 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 357348011444 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 357348011445 active site 357348011446 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 357348011447 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 357348011448 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 357348011449 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357348011450 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 357348011451 NAD(P) binding site [chemical binding]; other site 357348011452 active site 357348011453 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 357348011454 Autoinducer binding domain; Region: Autoind_bind; pfam03472 357348011455 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 357348011456 DNA binding residues [nucleotide binding] 357348011457 dimerization interface [polypeptide binding]; other site 357348011458 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 357348011459 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 357348011460 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 357348011461 active site 357348011462 non-prolyl cis peptide bond; other site 357348011463 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 357348011464 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 357348011465 Walker A/P-loop; other site 357348011466 ATP binding site [chemical binding]; other site 357348011467 Q-loop/lid; other site 357348011468 ABC transporter signature motif; other site 357348011469 Walker B; other site 357348011470 D-loop; other site 357348011471 H-loop/switch region; other site 357348011472 NIL domain; Region: NIL; pfam09383 357348011473 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348011474 dimer interface [polypeptide binding]; other site 357348011475 conserved gate region; other site 357348011476 ABC-ATPase subunit interface; other site 357348011477 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 357348011478 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 357348011479 Flavin binding site [chemical binding]; other site 357348011480 transcriptional regulator NanR; Provisional; Region: PRK03837 357348011481 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 357348011482 DNA-binding site [nucleotide binding]; DNA binding site 357348011483 FCD domain; Region: FCD; pfam07729 357348011484 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 357348011485 Cysteine-rich domain; Region: CCG; pfam02754 357348011486 Cysteine-rich domain; Region: CCG; pfam02754 357348011487 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 357348011488 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 357348011489 4Fe-4S binding domain; Region: Fer4; pfam00037 357348011490 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 357348011491 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 357348011492 glycolate transporter; Provisional; Region: PRK09695 357348011493 L-lactate permease; Region: Lactate_perm; cl00701 357348011494 Predicted membrane protein [Function unknown]; Region: COG2259 357348011495 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348011496 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348011497 metabolite-proton symporter; Region: 2A0106; TIGR00883 357348011498 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348011499 putative substrate translocation pore; other site 357348011500 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 357348011501 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 357348011502 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 357348011503 dimer interface [polypeptide binding]; other site 357348011504 NADP binding site [chemical binding]; other site 357348011505 catalytic residues [active] 357348011506 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 357348011507 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 357348011508 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 357348011509 inhibitor site; inhibition site 357348011510 active site 357348011511 dimer interface [polypeptide binding]; other site 357348011512 catalytic residue [active] 357348011513 hydroxyproline-2-epimerase; Provisional; Region: PRK13970 357348011514 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 357348011515 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 357348011516 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 357348011517 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 357348011518 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 357348011519 PAS fold; Region: PAS_4; pfam08448 357348011520 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 357348011521 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357348011522 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 357348011523 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 357348011524 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 357348011525 dimer interface [polypeptide binding]; other site 357348011526 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 357348011527 active site 357348011528 Fe binding site [ion binding]; other site 357348011529 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 357348011530 Dehydroquinase class II; Region: DHquinase_II; pfam01220 357348011531 active site 357348011532 trimer interface [polypeptide binding]; other site 357348011533 dimer interface [polypeptide binding]; other site 357348011534 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 357348011535 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 357348011536 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 357348011537 shikimate binding site; other site 357348011538 NAD(P) binding site [chemical binding]; other site 357348011539 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348011540 D-galactonate transporter; Region: 2A0114; TIGR00893 357348011541 putative substrate translocation pore; other site 357348011542 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348011543 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 357348011544 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 357348011545 catalytic residue [active] 357348011546 2-aminoethylphosphonate ABC transporter, periplasmic 2-aminoethylphosphonate binding protein; Region: PhnS; TIGR03227 357348011547 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 357348011548 2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT; Region: PhnT; TIGR03258 357348011549 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357348011550 Walker A/P-loop; other site 357348011551 ATP binding site [chemical binding]; other site 357348011552 Q-loop/lid; other site 357348011553 ABC transporter signature motif; other site 357348011554 Walker B; other site 357348011555 D-loop; other site 357348011556 H-loop/switch region; other site 357348011557 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 357348011558 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348011559 dimer interface [polypeptide binding]; other site 357348011560 conserved gate region; other site 357348011561 putative PBP binding loops; other site 357348011562 ABC-ATPase subunit interface; other site 357348011563 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 357348011564 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 357348011565 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 357348011566 putative phosphonoacetaldehyde dehydrogenase; Region: PhnAcAld_DH; TIGR03250 357348011567 Streptomyces putative phosphonoformaldehyde dehydrogenase PhpJ-like; Region: ALDH_PhpJ; cd07146 357348011568 NAD(P) binding site [chemical binding]; other site 357348011569 catalytic residues [active] 357348011570 phosphonate degradation operons associated HDIG domain protein; Region: Phn-HD; TIGR03276 357348011571 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 357348011572 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 357348011573 DNA binding residues [nucleotide binding] 357348011574 dimer interface [polypeptide binding]; other site 357348011575 copper binding site [ion binding]; other site 357348011576 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 357348011577 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 357348011578 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 357348011579 active site 357348011580 catalytic tetrad [active] 357348011581 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK13394 357348011582 classical (c) SDRs; Region: SDR_c; cd05233 357348011583 NAD(P) binding site [chemical binding]; other site 357348011584 active site 357348011585 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 357348011586 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 357348011587 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348011588 homodimer interface [polypeptide binding]; other site 357348011589 catalytic residue [active] 357348011590 excinuclease ABC subunit B; Provisional; Region: PRK05298 357348011591 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 357348011592 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 357348011593 ATP-binding site [chemical binding]; other site 357348011594 ATP binding site [chemical binding]; other site 357348011595 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 357348011596 nucleotide binding region [chemical binding]; other site 357348011597 ATP-binding site [chemical binding]; other site 357348011598 Ultra-violet resistance protein B; Region: UvrB; pfam12344 357348011599 UvrB/uvrC motif; Region: UVR; pfam02151 357348011600 Fe2+ transport protein; Region: Iron_transport; pfam10634 357348011601 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 357348011602 Iron permease FTR1 family; Region: FTR1; cl00475 357348011603 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 357348011604 4Fe-4S binding domain; Region: Fer4_5; pfam12801 357348011605 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 357348011606 Hemin uptake protein hemP; Region: hemP; pfam10636 357348011607 DUF1857, an uncharacterized ligand-binding domain of the SRPBCC domain superfamily; Region: SRPBCC_DUF1857; cd08863 357348011608 putative hydrophobic ligand binding site [chemical binding]; other site 357348011609 Pirin-related protein [General function prediction only]; Region: COG1741 357348011610 Pirin; Region: Pirin; pfam02678 357348011611 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 357348011612 LysR family transcriptional regulator; Provisional; Region: PRK14997 357348011613 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348011614 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 357348011615 putative effector binding pocket; other site 357348011616 putative dimerization interface [polypeptide binding]; other site 357348011617 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 357348011618 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 357348011619 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 357348011620 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 357348011621 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 357348011622 glutamate racemase; Provisional; Region: PRK00865 357348011623 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 357348011624 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 357348011625 heme binding site [chemical binding]; other site 357348011626 ferroxidase pore; other site 357348011627 ferroxidase diiron center [ion binding]; other site 357348011628 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 357348011629 Fumarase C-terminus; Region: Fumerase_C; pfam05683 357348011630 hypothetical protein; Provisional; Region: PRK05208 357348011631 EamA-like transporter family; Region: EamA; pfam00892 357348011632 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 357348011633 EamA-like transporter family; Region: EamA; pfam00892 357348011634 acetyl-CoA synthetase; Provisional; Region: PRK00174 357348011635 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 357348011636 active site 357348011637 CoA binding site [chemical binding]; other site 357348011638 acyl-activating enzyme (AAE) consensus motif; other site 357348011639 AMP binding site [chemical binding]; other site 357348011640 acetate binding site [chemical binding]; other site 357348011641 Domain of unknown function (DUF4212); Region: DUF4212; pfam13937 357348011642 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 357348011643 probable sodium:solute symporter, VC_2705 subfamily; Region: Na_symport_lg; TIGR03648 357348011644 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 357348011645 SPFH domain / Band 7 family; Region: Band_7; pfam01145 357348011646 Integrase core domain; Region: rve; pfam00665 357348011647 Integrase core domain; Region: rve_3; pfam13683 357348011648 Protein of unknown function (DUF497); Region: DUF497; pfam04365 357348011649 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 357348011650 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 357348011651 Integrase core domain; Region: rve; pfam00665 357348011652 Integrase core domain; Region: rve_3; pfam13683 357348011653 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 357348011654 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 357348011655 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 357348011656 DNA-binding interface [nucleotide binding]; DNA binding site 357348011657 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 357348011658 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 357348011659 active site 357348011660 metal binding site [ion binding]; metal-binding site 357348011661 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 357348011662 Integrase core domain; Region: rve; pfam00665 357348011663 Integrase core domain; Region: rve_3; pfam13683 357348011664 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 357348011665 Bacterial Ig-like domain; Region: Big_5; pfam13205 357348011666 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 357348011667 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 357348011668 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 357348011669 PYR/PP interface [polypeptide binding]; other site 357348011670 dimer interface [polypeptide binding]; other site 357348011671 TPP binding site [chemical binding]; other site 357348011672 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 357348011673 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 357348011674 TPP-binding site [chemical binding]; other site 357348011675 dimer interface [polypeptide binding]; other site 357348011676 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 357348011677 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 357348011678 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 357348011679 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 357348011680 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 357348011681 SLBB domain; Region: SLBB; pfam10531 357348011682 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 357348011683 Chain length determinant protein; Region: Wzz; pfam02706 357348011684 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 357348011685 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 357348011686 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 357348011687 substrate binding site; other site 357348011688 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 357348011689 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 357348011690 NAD binding site [chemical binding]; other site 357348011691 homotetramer interface [polypeptide binding]; other site 357348011692 homodimer interface [polypeptide binding]; other site 357348011693 substrate binding site [chemical binding]; other site 357348011694 active site 357348011695 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 357348011696 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 357348011697 inhibitor-cofactor binding pocket; inhibition site 357348011698 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348011699 catalytic residue [active] 357348011700 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 357348011701 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 357348011702 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 357348011703 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 357348011704 inhibitor-cofactor binding pocket; inhibition site 357348011705 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348011706 catalytic residue [active] 357348011707 Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513 357348011708 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 357348011709 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 357348011710 active site 357348011711 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 357348011712 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 357348011713 putative active site [active] 357348011714 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 357348011715 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 357348011716 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 357348011717 putative active site [active] 357348011718 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 357348011719 trimer interface [polypeptide binding]; other site 357348011720 active site 357348011721 substrate binding site [chemical binding]; other site 357348011722 CoA binding site [chemical binding]; other site 357348011723 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 357348011724 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 357348011725 active site 357348011726 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357348011727 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348011728 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 357348011729 putative effector binding pocket; other site 357348011730 dimerization interface [polypeptide binding]; other site 357348011731 Pirin-related protein [General function prediction only]; Region: COG1741 357348011732 Pirin; Region: Pirin; pfam02678 357348011733 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 357348011734 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 357348011735 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 357348011736 ligand binding site [chemical binding]; other site 357348011737 flexible hinge region; other site 357348011738 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 357348011739 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357348011740 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357348011741 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357348011742 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357348011743 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357348011744 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 357348011745 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348011746 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 357348011747 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357348011748 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348011749 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 357348011750 putative effector binding pocket; other site 357348011751 dimerization interface [polypeptide binding]; other site 357348011752 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 357348011753 Isochorismatase family; Region: Isochorismatase; pfam00857 357348011754 catalytic triad [active] 357348011755 dimer interface [polypeptide binding]; other site 357348011756 conserved cis-peptide bond; other site 357348011757 Protein of unknown function (DUF1427); Region: DUF1427; pfam07235 357348011758 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 357348011759 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 357348011760 active site 357348011761 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 357348011762 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 357348011763 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 357348011764 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 357348011765 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 357348011766 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 357348011767 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 357348011768 NAD binding site [chemical binding]; other site 357348011769 active site 357348011770 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 357348011771 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 357348011772 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 357348011773 DNA-binding site [nucleotide binding]; DNA binding site 357348011774 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 357348011775 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348011776 homodimer interface [polypeptide binding]; other site 357348011777 catalytic residue [active] 357348011778 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 357348011779 Putative amidotransferase; Region: DUF4066; pfam13278 357348011780 conserved cys residue [active] 357348011781 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 357348011782 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 357348011783 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 357348011784 hypothetical protein; Provisional; Region: PRK08609 357348011785 active site 357348011786 primer binding site [nucleotide binding]; other site 357348011787 NTP binding site [chemical binding]; other site 357348011788 metal binding triad [ion binding]; metal-binding site 357348011789 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 357348011790 active site 357348011791 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 357348011792 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 357348011793 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 357348011794 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 357348011795 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 357348011796 CopC domain; Region: CopC; pfam04234 357348011797 Copper resistance protein D; Region: CopD; pfam05425 357348011798 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 357348011799 HAMP domain; Region: HAMP; pfam00672 357348011800 dimerization interface [polypeptide binding]; other site 357348011801 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 357348011802 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 357348011803 dimer interface [polypeptide binding]; other site 357348011804 putative CheW interface [polypeptide binding]; other site 357348011805 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 357348011806 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 357348011807 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 357348011808 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 357348011809 Protein of unknown function (DUF3138); Region: DUF3138; pfam11336 357348011810 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 357348011811 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 357348011812 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348011813 dimer interface [polypeptide binding]; other site 357348011814 conserved gate region; other site 357348011815 putative PBP binding loops; other site 357348011816 ABC-ATPase subunit interface; other site 357348011817 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 357348011818 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348011819 dimer interface [polypeptide binding]; other site 357348011820 conserved gate region; other site 357348011821 putative PBP binding loops; other site 357348011822 ABC-ATPase subunit interface; other site 357348011823 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 357348011824 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357348011825 Walker A/P-loop; other site 357348011826 ATP binding site [chemical binding]; other site 357348011827 Q-loop/lid; other site 357348011828 ABC transporter signature motif; other site 357348011829 Walker B; other site 357348011830 D-loop; other site 357348011831 H-loop/switch region; other site 357348011832 TOBE domain; Region: TOBE_2; pfam08402 357348011833 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 357348011834 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 357348011835 putative aminotransferase; Validated; Region: PRK07480 357348011836 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 357348011837 inhibitor-cofactor binding pocket; inhibition site 357348011838 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348011839 catalytic residue [active] 357348011840 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 357348011841 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 357348011842 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 357348011843 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 357348011844 catalytic triad [active] 357348011845 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 357348011846 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 357348011847 non-specific DNA binding site [nucleotide binding]; other site 357348011848 salt bridge; other site 357348011849 sequence-specific DNA binding site [nucleotide binding]; other site 357348011850 Cupin domain; Region: Cupin_2; pfam07883 357348011851 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 357348011852 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 357348011853 NAD(P) binding site [chemical binding]; other site 357348011854 catalytic residues [active] 357348011855 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 357348011856 agmatinase; Region: agmatinase; TIGR01230 357348011857 oligomer interface [polypeptide binding]; other site 357348011858 putative active site [active] 357348011859 Mn binding site [ion binding]; other site 357348011860 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 357348011861 oligomerisation interface [polypeptide binding]; other site 357348011862 mobile loop; other site 357348011863 roof hairpin; other site 357348011864 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 357348011865 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 357348011866 ring oligomerisation interface [polypeptide binding]; other site 357348011867 ATP/Mg binding site [chemical binding]; other site 357348011868 stacking interactions; other site 357348011869 hinge regions; other site 357348011870 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 357348011871 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 357348011872 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 357348011873 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 357348011874 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 357348011875 active site 357348011876 dimer interface [polypeptide binding]; other site 357348011877 effector binding site; other site 357348011878 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 357348011879 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 357348011880 acyl-activating enzyme (AAE) consensus motif; other site 357348011881 AMP binding site [chemical binding]; other site 357348011882 active site 357348011883 CoA binding site [chemical binding]; other site 357348011884 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 357348011885 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 357348011886 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 357348011887 active site 357348011888 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 357348011889 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 357348011890 dimer interface [polypeptide binding]; other site 357348011891 active site 357348011892 CoA binding pocket [chemical binding]; other site 357348011893 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 357348011894 acyl-CoA synthetase; Validated; Region: PRK05850 357348011895 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 357348011896 acyl-activating enzyme (AAE) consensus motif; other site 357348011897 active site 357348011898 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 357348011899 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 357348011900 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 357348011901 active site 357348011902 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 357348011903 MAPEG family; Region: MAPEG; cl09190 357348011904 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895 357348011905 putative hydrophobic ligand binding site [chemical binding]; other site 357348011906 Integrase core domain; Region: rve_3; pfam13683 357348011907 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 357348011908 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 357348011909 catalytic residue [active] 357348011910 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 357348011911 catalytic residues [active] 357348011912 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 357348011913 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 357348011914 peroxiredoxin; Region: AhpC; TIGR03137 357348011915 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 357348011916 dimer interface [polypeptide binding]; other site 357348011917 decamer (pentamer of dimers) interface [polypeptide binding]; other site 357348011918 catalytic triad [active] 357348011919 peroxidatic and resolving cysteines [active] 357348011920 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 357348011921 Chitin binding domain; Region: Chitin_bind_3; pfam03067 357348011922 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 357348011923 putative FMN binding site [chemical binding]; other site 357348011924 Uncharacterized conserved protein [Function unknown]; Region: COG2308 357348011925 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 357348011926 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 357348011927 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 357348011928 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 357348011929 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 357348011930 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 357348011931 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 357348011932 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 357348011933 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 357348011934 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 357348011935 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; pfam04174 357348011936 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 357348011937 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 357348011938 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 357348011939 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 357348011940 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 357348011941 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 357348011942 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 357348011943 DNA-binding site [nucleotide binding]; DNA binding site 357348011944 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 357348011945 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348011946 homodimer interface [polypeptide binding]; other site 357348011947 catalytic residue [active] 357348011948 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 357348011949 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348011950 putative substrate translocation pore; other site 357348011951 Predicted membrane protein [Function unknown]; Region: COG1289 357348011952 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 357348011953 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 357348011954 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 357348011955 conserved cys residue [active] 357348011956 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357348011957 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 357348011958 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 357348011959 conserved cys residue [active] 357348011960 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 357348011961 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 357348011962 catalytic residue [active] 357348011963 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 357348011964 phosphonopyruvate decarboxylase; Region: Ppyr-DeCO2ase; TIGR03297 357348011965 PYR/PP interface [polypeptide binding]; other site 357348011966 dimer interface [polypeptide binding]; other site 357348011967 TPP binding site [chemical binding]; other site 357348011968 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 357348011969 TPP-binding site [chemical binding]; other site 357348011970 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 357348011971 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 357348011972 tetramer interface [polypeptide binding]; other site 357348011973 active site 357348011974 Mg2+/Mn2+ binding site [ion binding]; other site 357348011975 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 357348011976 active site 357348011977 metal-binding site 357348011978 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 357348011979 active site 357348011980 metal-binding site 357348011981 putative membrane protein; Region: HpnL; TIGR03476 357348011982 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 357348011983 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 357348011984 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 357348011985 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 357348011986 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 357348011987 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 357348011988 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 357348011989 type VI secretion protein, VC_A0107 family; Region: VI_chp_5; TIGR03358 357348011990 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 357348011991 Protein of unknown function (DUF877); Region: DUF877; pfam05943 357348011992 Protein of unknown function (DUF796); Region: DUF796; pfam05638 357348011993 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 357348011994 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 357348011995 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 357348011996 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 357348011997 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 357348011998 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357348011999 Walker A motif; other site 357348012000 ATP binding site [chemical binding]; other site 357348012001 Walker B motif; other site 357348012002 arginine finger; other site 357348012003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 357348012004 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357348012005 Walker A motif; other site 357348012006 ATP binding site [chemical binding]; other site 357348012007 Walker B motif; other site 357348012008 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 357348012009 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 357348012010 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 357348012011 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 357348012012 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 357348012013 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 357348012014 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 357348012015 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; cl02212 357348012016 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 357348012017 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 357348012018 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 357348012019 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 357348012020 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 357348012021 Protein of unknown function (DUF3540); Region: DUF3540; pfam12059 357348012022 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 357348012023 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 357348012024 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 357348012025 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 357348012026 hypothetical protein; Provisional; Region: PRK14693 357348012027 type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349 357348012028 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 357348012029 ligand binding site [chemical binding]; other site 357348012030 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 357348012031 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 357348012032 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 357348012033 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 357348012034 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 357348012035 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 357348012036 active site 357348012037 TDP-binding site; other site 357348012038 acceptor substrate-binding pocket; other site 357348012039 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 357348012040 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348012041 putative substrate translocation pore; other site 357348012042 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348012043 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 357348012044 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 357348012045 Ligand binding site; other site 357348012046 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 357348012047 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 357348012048 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 357348012049 HlyD family secretion protein; Region: HlyD_3; pfam13437 357348012050 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 357348012051 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 357348012052 substrate binding [chemical binding]; other site 357348012053 active site 357348012054 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 357348012055 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 357348012056 active site 357348012057 Transcriptional regulators [Transcription]; Region: PurR; COG1609 357348012058 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 357348012059 DNA binding site [nucleotide binding] 357348012060 domain linker motif; other site 357348012061 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 357348012062 ligand binding site [chemical binding]; other site 357348012063 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 357348012064 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 357348012065 NAD binding site [chemical binding]; other site 357348012066 catalytic Zn binding site [ion binding]; other site 357348012067 structural Zn binding site [ion binding]; other site 357348012068 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 357348012069 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 357348012070 conserved cys residue [active] 357348012071 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357348012072 serine hydroxymethyltransferase; Reviewed; Region: PRK13034 357348012073 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 357348012074 dimer interface [polypeptide binding]; other site 357348012075 active site 357348012076 glycine-pyridoxal phosphate binding site [chemical binding]; other site 357348012077 folate binding site [chemical binding]; other site 357348012078 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 357348012079 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 357348012080 active site 357348012081 dimer interface [polypeptide binding]; other site 357348012082 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 357348012083 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 357348012084 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 357348012085 putative active site [active] 357348012086 putative FMN binding site [chemical binding]; other site 357348012087 putative substrate binding site [chemical binding]; other site 357348012088 putative catalytic residue [active] 357348012089 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 357348012090 Domain of unknown function (DUF3483); Region: DUF3483; pfam11982 357348012091 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 357348012092 Cysteine-rich domain; Region: CCG; pfam02754 357348012093 Cysteine-rich domain; Region: CCG; pfam02754 357348012094 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 357348012095 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 357348012096 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 357348012097 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 357348012098 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 357348012099 [2Fe-2S] cluster binding site [ion binding]; other site 357348012100 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 357348012101 putative alpha subunit interface [polypeptide binding]; other site 357348012102 putative active site [active] 357348012103 putative substrate binding site [chemical binding]; other site 357348012104 Fe binding site [ion binding]; other site 357348012105 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 357348012106 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 357348012107 FAD binding pocket [chemical binding]; other site 357348012108 FAD binding motif [chemical binding]; other site 357348012109 phosphate binding motif [ion binding]; other site 357348012110 beta-alpha-beta structure motif; other site 357348012111 NAD binding pocket [chemical binding]; other site 357348012112 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 357348012113 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 357348012114 catalytic loop [active] 357348012115 iron binding site [ion binding]; other site 357348012116 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 357348012117 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 357348012118 Amino acid permease; Region: AA_permease_2; pfam13520 357348012119 formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011 357348012120 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 357348012121 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 357348012122 putative active site [active] 357348012123 putative substrate binding site [chemical binding]; other site 357348012124 putative cosubstrate binding site; other site 357348012125 catalytic site [active] 357348012126 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 357348012127 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348012128 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 357348012129 substrate binding pocket [chemical binding]; other site 357348012130 dimerization interface [polypeptide binding]; other site 357348012131 choline-sulfatase; Region: chol_sulfatase; TIGR03417 357348012132 Sulfatase; Region: Sulfatase; cl17466 357348012133 Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411 357348012134 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 357348012135 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 357348012136 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 357348012137 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 357348012138 trimer interface [polypeptide binding]; other site 357348012139 eyelet of channel; other site 357348012140 M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase; Region: M28_AAP; cd03879 357348012141 Peptidase family M28; Region: Peptidase_M28; pfam04389 357348012142 active site 357348012143 metal binding site [ion binding]; metal-binding site 357348012144 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 357348012145 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 357348012146 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 357348012147 Zn binding site [ion binding]; other site 357348012148 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 357348012149 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 357348012150 conserved cys residue [active] 357348012151 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357348012152 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 357348012153 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 357348012154 Uncharacterized conserved protein [Function unknown]; Region: COG3246 357348012155 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 357348012156 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 357348012157 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 357348012158 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 357348012159 active site 357348012160 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 357348012161 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 357348012162 short chain dehydrogenase; Provisional; Region: PRK06197 357348012163 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 357348012164 putative NAD(P) binding site [chemical binding]; other site 357348012165 active site 357348012166 Domain of unknown function (DUF3331); Region: DUF3331; pfam11811 357348012167 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 357348012168 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 357348012169 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 357348012170 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 357348012171 dimerization interface [polypeptide binding]; other site 357348012172 ligand binding site [chemical binding]; other site 357348012173 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 357348012174 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 357348012175 TM-ABC transporter signature motif; other site 357348012176 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 357348012177 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 357348012178 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 357348012179 TM-ABC transporter signature motif; other site 357348012180 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 357348012181 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 357348012182 Walker A/P-loop; other site 357348012183 ATP binding site [chemical binding]; other site 357348012184 Q-loop/lid; other site 357348012185 ABC transporter signature motif; other site 357348012186 Walker B; other site 357348012187 D-loop; other site 357348012188 H-loop/switch region; other site 357348012189 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 357348012190 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 357348012191 Walker A/P-loop; other site 357348012192 ATP binding site [chemical binding]; other site 357348012193 Q-loop/lid; other site 357348012194 ABC transporter signature motif; other site 357348012195 Walker B; other site 357348012196 D-loop; other site 357348012197 H-loop/switch region; other site 357348012198 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 357348012199 Peptidase family M23; Region: Peptidase_M23; pfam01551 357348012200 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 357348012201 salicylate biosynthesis isochorismate synthase; Validated; Region: PRK07054 357348012202 chorismate binding enzyme; Region: Chorismate_bind; cl10555 357348012203 isochorismate-pyruvate lyase; Reviewed; Region: PRK07075 357348012204 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 357348012205 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 357348012206 nucleophilic elbow; other site 357348012207 catalytic triad; other site 357348012208 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 357348012209 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 357348012210 acyl-activating enzyme (AAE) consensus motif; other site 357348012211 active site 357348012212 AMP binding site [chemical binding]; other site 357348012213 substrate binding site [chemical binding]; other site 357348012214 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 357348012215 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357348012216 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 357348012217 Condensation domain; Region: Condensation; pfam00668 357348012218 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 357348012219 Nonribosomal peptide synthase; Region: NRPS; pfam08415 357348012220 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 357348012221 acyl-activating enzyme (AAE) consensus motif; other site 357348012222 AMP binding site [chemical binding]; other site 357348012223 Methyltransferase domain; Region: Methyltransf_12; pfam08242 357348012224 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 357348012225 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 357348012226 Condensation domain; Region: Condensation; pfam00668 357348012227 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 357348012228 Nonribosomal peptide synthase; Region: NRPS; pfam08415 357348012229 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 357348012230 acyl-activating enzyme (AAE) consensus motif; other site 357348012231 AMP binding site [chemical binding]; other site 357348012232 Methyltransferase domain; Region: Methyltransf_12; pfam08242 357348012233 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 357348012234 thiazolinyl imide reductase; Region: thiaz-red; TIGR01761 357348012235 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 357348012236 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 357348012237 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357348012238 Walker A/P-loop; other site 357348012239 ATP binding site [chemical binding]; other site 357348012240 Q-loop/lid; other site 357348012241 ABC transporter signature motif; other site 357348012242 Walker B; other site 357348012243 D-loop; other site 357348012244 H-loop/switch region; other site 357348012245 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 357348012246 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357348012247 Walker A/P-loop; other site 357348012248 ATP binding site [chemical binding]; other site 357348012249 Q-loop/lid; other site 357348012250 ABC transporter signature motif; other site 357348012251 Walker B; other site 357348012252 D-loop; other site 357348012253 H-loop/switch region; other site 357348012254 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism]; Region: FhuE; COG4773 357348012255 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 357348012256 N-terminal plug; other site 357348012257 ligand-binding site [chemical binding]; other site 357348012258 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 357348012259 siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718 357348012260 Acetyl-coenzyme A transporter 1; Region: Acatn; pfam13000 357348012261 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 357348012262 catalytic loop [active] 357348012263 iron binding site [ion binding]; other site 357348012264 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 357348012265 GAF domain; Region: GAF; pfam01590 357348012266 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357348012267 Walker A motif; other site 357348012268 ATP binding site [chemical binding]; other site 357348012269 Walker B motif; other site 357348012270 arginine finger; other site 357348012271 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 357348012272 Protein of unknown function (DUF2964); Region: DUF2964; pfam11177 357348012273 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 357348012274 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 357348012275 TIGR02594 family protein; Region: TIGR02594 357348012276 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 357348012277 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 357348012278 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348012279 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 357348012280 dimerization interface [polypeptide binding]; other site 357348012281 substrate binding pocket [chemical binding]; other site 357348012282 putative phosphonoacetaldehyde dehydrogenase; Region: PhnAcAld_DH; TIGR03250 357348012283 Streptomyces putative phosphonoformaldehyde dehydrogenase PhpJ-like; Region: ALDH_PhpJ; cd07146 357348012284 NAD(P) binding site [chemical binding]; other site 357348012285 catalytic residues [active] 357348012286 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 357348012287 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 357348012288 active site 357348012289 iron coordination sites [ion binding]; other site 357348012290 substrate binding pocket [chemical binding]; other site 357348012291 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 357348012292 phosphonopyruvate decarboxylase; Region: Ppyr-DeCO2ase; TIGR03297 357348012293 PYR/PP interface [polypeptide binding]; other site 357348012294 dimer interface [polypeptide binding]; other site 357348012295 TPP binding site [chemical binding]; other site 357348012296 Thiamine pyrophosphate (TPP) family, PpyrDC subfamily, TPP-binding module; composed of proteins similar to phosphonopyruvate decarboxylase (PpyrDC) proteins. PpyrDC is a homotrimeric enzyme which functions in the biosynthesis of C-P compounds such as...; Region: TPP_PpyrDC; cd03371 357348012297 TPP-binding site; other site 357348012298 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 357348012299 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 357348012300 tetramer interface [polypeptide binding]; other site 357348012301 active site 357348012302 Mg2+/Mn2+ binding site [ion binding]; other site 357348012303 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 357348012304 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 357348012305 short chain dehydrogenase; Validated; Region: PRK05855 357348012306 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 357348012307 classical (c) SDRs; Region: SDR_c; cd05233 357348012308 NAD(P) binding site [chemical binding]; other site 357348012309 active site 357348012310 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 357348012311 active site 357348012312 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 357348012313 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 357348012314 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 357348012315 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 357348012316 active site 357348012317 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 357348012318 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 357348012319 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357348012320 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357348012321 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 357348012322 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 357348012323 active site 357348012324 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 357348012325 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_1; cd05974 357348012326 active site 357348012327 acyl-activating enzyme (AAE) consensus motif; other site 357348012328 putative CoA binding site [chemical binding]; other site 357348012329 AMP binding site [chemical binding]; other site 357348012330 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 357348012331 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 357348012332 tetrameric interface [polypeptide binding]; other site 357348012333 NAD binding site [chemical binding]; other site 357348012334 catalytic residues [active] 357348012335 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 357348012336 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 357348012337 enoyl-CoA hydratase; Provisional; Region: PRK09076 357348012338 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 357348012339 substrate binding site [chemical binding]; other site 357348012340 oxyanion hole (OAH) forming residues; other site 357348012341 trimer interface [polypeptide binding]; other site 357348012342 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 357348012343 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 357348012344 substrate binding site [chemical binding]; other site 357348012345 oxyanion hole (OAH) forming residues; other site 357348012346 trimer interface [polypeptide binding]; other site 357348012347 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 357348012348 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 357348012349 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 357348012350 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 357348012351 Walker A/P-loop; other site 357348012352 ATP binding site [chemical binding]; other site 357348012353 Q-loop/lid; other site 357348012354 ABC transporter signature motif; other site 357348012355 Walker B; other site 357348012356 D-loop; other site 357348012357 H-loop/switch region; other site 357348012358 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 357348012359 FtsX-like permease family; Region: FtsX; pfam02687 357348012360 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 357348012361 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 357348012362 HlyD family secretion protein; Region: HlyD_3; pfam13437 357348012363 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 357348012364 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 357348012365 active site 357348012366 dimer interface [polypeptide binding]; other site 357348012367 non-prolyl cis peptide bond; other site 357348012368 insertion regions; other site 357348012369 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 357348012370 B1 nucleotide binding pocket [chemical binding]; other site 357348012371 B2 nucleotide binding pocket [chemical binding]; other site 357348012372 CAS motifs; other site 357348012373 active site 357348012374 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 357348012375 glutaminase; Provisional; Region: PRK00971 357348012376 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 357348012377 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348012378 active site 357348012379 phosphorylation site [posttranslational modification] 357348012380 intermolecular recognition site; other site 357348012381 dimerization interface [polypeptide binding]; other site 357348012382 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357348012383 DNA binding site [nucleotide binding] 357348012384 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357348012385 dimer interface [polypeptide binding]; other site 357348012386 phosphorylation site [posttranslational modification] 357348012387 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357348012388 ATP binding site [chemical binding]; other site 357348012389 Mg2+ binding site [ion binding]; other site 357348012390 G-X-G motif; other site 357348012391 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 357348012392 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 357348012393 active site 357348012394 nucleophile elbow; other site 357348012395 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 357348012396 Surface antigen; Region: Bac_surface_Ag; pfam01103 357348012397 rod shape-determining protein MreB; Provisional; Region: PRK13930 357348012398 MreB and similar proteins; Region: MreB_like; cd10225 357348012399 nucleotide binding site [chemical binding]; other site 357348012400 Mg binding site [ion binding]; other site 357348012401 putative protofilament interaction site [polypeptide binding]; other site 357348012402 RodZ interaction site [polypeptide binding]; other site 357348012403 Cytochrome c; Region: Cytochrom_C; cl11414 357348012404 HD domain; Region: HD_3; pfam13023 357348012405 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 357348012406 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 357348012407 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 357348012408 substrate binding pocket [chemical binding]; other site 357348012409 aspartate-rich region 1; other site 357348012410 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 357348012411 putative dimer interface [polypeptide binding]; other site 357348012412 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 357348012413 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 357348012414 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 357348012415 C-terminal domain interface [polypeptide binding]; other site 357348012416 GSH binding site (G-site) [chemical binding]; other site 357348012417 dimer interface [polypeptide binding]; other site 357348012418 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 357348012419 N-terminal domain interface [polypeptide binding]; other site 357348012420 dimer interface [polypeptide binding]; other site 357348012421 substrate binding pocket (H-site) [chemical binding]; other site 357348012422 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 357348012423 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357348012424 dimer interface [polypeptide binding]; other site 357348012425 phosphorylation site [posttranslational modification] 357348012426 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357348012427 ATP binding site [chemical binding]; other site 357348012428 Mg2+ binding site [ion binding]; other site 357348012429 G-X-G motif; other site 357348012430 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 357348012431 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348012432 active site 357348012433 phosphorylation site [posttranslational modification] 357348012434 intermolecular recognition site; other site 357348012435 dimerization interface [polypeptide binding]; other site 357348012436 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357348012437 DNA binding site [nucleotide binding] 357348012438 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 357348012439 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 357348012440 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 357348012441 putative active site [active] 357348012442 Uncharacterized small protein (DUF2158); Region: DUF2158; pfam09926 357348012443 Superinfection immunity protein; Region: Imm_superinfect; pfam14373 357348012444 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 357348012445 active site residue [active] 357348012446 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 357348012447 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 357348012448 conserved cys residue [active] 357348012449 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357348012450 hypothetical protein; Provisional; Region: PRK07907 357348012451 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682 357348012452 metal binding site [ion binding]; metal-binding site 357348012453 putative dimer interface [polypeptide binding]; other site 357348012454 TfoX N-terminal domain; Region: TfoX_N; pfam04993 357348012455 NnrU protein; Region: NnrU; pfam07298 357348012456 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 357348012457 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 357348012458 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 357348012459 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 357348012460 Integrase core domain; Region: rve_3; pfam13683 357348012461 VirK protein; Region: VirK; pfam06903 357348012462 Protein of unknown function (DUF1153); Region: DUF1153; pfam06627 357348012463 Integrase core domain; Region: rve_3; pfam13683 357348012464 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 357348012465 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 357348012466 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 357348012467 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 357348012468 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348012469 putative substrate translocation pore; other site 357348012470 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348012471 Trehalase; Region: Trehalase; cl17346 357348012472 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 357348012473 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 357348012474 Subunit I/III interface [polypeptide binding]; other site 357348012475 Autoinducer binding domain; Region: Autoind_bind; pfam03472 357348012476 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 357348012477 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 357348012478 DNA binding residues [nucleotide binding] 357348012479 dimerization interface [polypeptide binding]; other site 357348012480 Autoinducer binding domain; Region: Autoind_bind; pfam03472 357348012481 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 357348012482 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 357348012483 active site 357348012484 dimer interface [polypeptide binding]; other site 357348012485 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 357348012486 Ligand Binding Site [chemical binding]; other site 357348012487 Molecular Tunnel; other site 357348012488 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 357348012489 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357348012490 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 357348012491 DNA binding site [nucleotide binding] 357348012492 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 357348012493 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 357348012494 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 357348012495 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 357348012496 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 357348012497 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 357348012498 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 357348012499 catalytic loop [active] 357348012500 iron binding site [ion binding]; other site 357348012501 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 357348012502 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 357348012503 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 357348012504 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357348012505 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357348012506 SnoaL-like domain; Region: SnoaL_2; pfam12680 357348012507 Protein of unknown function (DUF3564); Region: DUF3564; pfam12087 357348012508 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 357348012509 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 357348012510 Flavin binding site [chemical binding]; other site 357348012511 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 357348012512 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 357348012513 active site 357348012514 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 357348012515 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 357348012516 active site 357348012517 non-prolyl cis peptide bond; other site 357348012518 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 357348012519 dimerization interface [polypeptide binding]; other site 357348012520 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357348012521 dimer interface [polypeptide binding]; other site 357348012522 phosphorylation site [posttranslational modification] 357348012523 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357348012524 ATP binding site [chemical binding]; other site 357348012525 Mg2+ binding site [ion binding]; other site 357348012526 G-X-G motif; other site 357348012527 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 357348012528 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348012529 active site 357348012530 phosphorylation site [posttranslational modification] 357348012531 intermolecular recognition site; other site 357348012532 dimerization interface [polypeptide binding]; other site 357348012533 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357348012534 DNA binding site [nucleotide binding] 357348012535 MltA-interacting protein MipA; Region: MipA; cl01504 357348012536 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 357348012537 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357348012538 NAD(P) binding site [chemical binding]; other site 357348012539 active site 357348012540 MarR family; Region: MarR_2; cl17246 357348012541 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 357348012542 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 357348012543 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 357348012544 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 357348012545 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 357348012546 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 357348012547 NAD binding site [chemical binding]; other site 357348012548 catalytic residues [active] 357348012549 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 357348012550 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 357348012551 putative active site [active] 357348012552 putative metal binding site [ion binding]; other site 357348012553 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 357348012554 putative substrate binding pocket [chemical binding]; other site 357348012555 trimer interface [polypeptide binding]; other site 357348012556 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 357348012557 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 357348012558 Helix-turn-helix domain; Region: HTH_18; pfam12833 357348012559 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357348012560 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 357348012561 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 357348012562 NAD(P) binding site [chemical binding]; other site 357348012563 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 357348012564 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 357348012565 trimer interface [polypeptide binding]; other site 357348012566 eyelet of channel; other site 357348012567 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 357348012568 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 357348012569 Walker A/P-loop; other site 357348012570 ATP binding site [chemical binding]; other site 357348012571 Q-loop/lid; other site 357348012572 ABC transporter signature motif; other site 357348012573 Walker B; other site 357348012574 D-loop; other site 357348012575 H-loop/switch region; other site 357348012576 TOBE domain; Region: TOBE_2; pfam08402 357348012577 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 357348012578 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348012579 dimer interface [polypeptide binding]; other site 357348012580 conserved gate region; other site 357348012581 ABC-ATPase subunit interface; other site 357348012582 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348012583 dimer interface [polypeptide binding]; other site 357348012584 conserved gate region; other site 357348012585 putative PBP binding loops; other site 357348012586 ABC-ATPase subunit interface; other site 357348012587 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 357348012588 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 357348012589 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 357348012590 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348012591 active site 357348012592 phosphorylation site [posttranslational modification] 357348012593 intermolecular recognition site; other site 357348012594 dimerization interface [polypeptide binding]; other site 357348012595 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357348012596 DNA binding site [nucleotide binding] 357348012597 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 357348012598 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357348012599 dimer interface [polypeptide binding]; other site 357348012600 phosphorylation site [posttranslational modification] 357348012601 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357348012602 ATP binding site [chemical binding]; other site 357348012603 Mg2+ binding site [ion binding]; other site 357348012604 G-X-G motif; other site 357348012605 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 357348012606 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 357348012607 MOSC domain; Region: MOSC; pfam03473 357348012608 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 357348012609 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 357348012610 trimer interface [polypeptide binding]; other site 357348012611 eyelet of channel; other site 357348012612 enoyl-CoA hydratase; Validated; Region: PRK08139 357348012613 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 357348012614 substrate binding site [chemical binding]; other site 357348012615 oxyanion hole (OAH) forming residues; other site 357348012616 trimer interface [polypeptide binding]; other site 357348012617 alanine racemase; Reviewed; Region: PRK13340 357348012618 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 357348012619 active site 357348012620 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 357348012621 substrate binding site [chemical binding]; other site 357348012622 catalytic residues [active] 357348012623 dimer interface [polypeptide binding]; other site 357348012624 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 357348012625 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 357348012626 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 357348012627 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 357348012628 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 357348012629 Protein of unknown function (DUF3455); Region: DUF3455; pfam11937 357348012630 Esterase/lipase [General function prediction only]; Region: COG1647 357348012631 MASE1; Region: MASE1; pfam05231 357348012632 PAS fold; Region: PAS_3; pfam08447 357348012633 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 357348012634 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 357348012635 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 357348012636 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 357348012637 potential catalytic triad [active] 357348012638 conserved cys residue [active] 357348012639 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 357348012640 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 357348012641 active site 357348012642 FMN binding site [chemical binding]; other site 357348012643 substrate binding site [chemical binding]; other site 357348012644 homotetramer interface [polypeptide binding]; other site 357348012645 catalytic residue [active] 357348012646 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07533 357348012647 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 357348012648 NAD binding site [chemical binding]; other site 357348012649 homotetramer interface [polypeptide binding]; other site 357348012650 homodimer interface [polypeptide binding]; other site 357348012651 substrate binding site [chemical binding]; other site 357348012652 active site 357348012653 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 357348012654 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 357348012655 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 357348012656 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357348012657 NAD(P) binding site [chemical binding]; other site 357348012658 active site 357348012659 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 357348012660 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 357348012661 DNA-binding site [nucleotide binding]; DNA binding site 357348012662 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 357348012663 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348012664 homodimer interface [polypeptide binding]; other site 357348012665 catalytic residue [active] 357348012666 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 357348012667 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357348012668 ATP binding site [chemical binding]; other site 357348012669 Mg2+ binding site [ion binding]; other site 357348012670 G-X-G motif; other site 357348012671 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 357348012672 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 357348012673 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 357348012674 ligand binding site [chemical binding]; other site 357348012675 flexible hinge region; other site 357348012676 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 357348012677 acyl-CoA synthetase; Validated; Region: PRK08162 357348012678 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 357348012679 acyl-activating enzyme (AAE) consensus motif; other site 357348012680 putative active site [active] 357348012681 AMP binding site [chemical binding]; other site 357348012682 putative CoA binding site [chemical binding]; other site 357348012683 Cache domain; Region: Cache_1; pfam02743 357348012684 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 357348012685 dimer interface [polypeptide binding]; other site 357348012686 putative CheW interface [polypeptide binding]; other site 357348012687 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 357348012688 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 357348012689 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 357348012690 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 357348012691 DXD motif; other site 357348012692 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 357348012693 HlyD family secretion protein; Region: HlyD_3; pfam13437 357348012694 HlyD family secretion protein; Region: HlyD_3; pfam13437 357348012695 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 357348012696 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357348012697 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348012698 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 357348012699 dimerization interface [polypeptide binding]; other site 357348012700 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 357348012701 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 357348012702 inhibitor-cofactor binding pocket; inhibition site 357348012703 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348012704 catalytic residue [active] 357348012705 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 357348012706 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 357348012707 tetrameric interface [polypeptide binding]; other site 357348012708 NAD binding site [chemical binding]; other site 357348012709 catalytic residues [active] 357348012710 Secretory lipase; Region: LIP; pfam03583 357348012711 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 357348012712 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 357348012713 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 357348012714 trimer interface [polypeptide binding]; other site 357348012715 eyelet of channel; other site 357348012716 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 357348012717 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 357348012718 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 357348012719 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 357348012720 DNA binding residues [nucleotide binding] 357348012721 dimerization interface [polypeptide binding]; other site 357348012722 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 357348012723 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 357348012724 homodimer interface [polypeptide binding]; other site 357348012725 homotetramer interface [polypeptide binding]; other site 357348012726 active site pocket [active] 357348012727 cleavage site 357348012728 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 357348012729 Fusaric acid resistance protein family; Region: FUSC; pfam04632 357348012730 transcriptional regulator; Provisional; Region: PRK10632 357348012731 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348012732 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 357348012733 putative effector binding pocket; other site 357348012734 dimerization interface [polypeptide binding]; other site 357348012735 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 357348012736 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 357348012737 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 357348012738 trimer interface [polypeptide binding]; other site 357348012739 eyelet of channel; other site 357348012740 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 357348012741 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 357348012742 cytosine permease; Provisional; Region: codB; PRK11017 357348012743 Na binding site [ion binding]; other site 357348012744 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 357348012745 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 357348012746 cytosine deaminase; Provisional; Region: PRK09230 357348012747 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 357348012748 active site 357348012749 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348012750 putative substrate translocation pore; other site 357348012751 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 357348012752 short chain dehydrogenase; Provisional; Region: PRK12829 357348012753 classical (c) SDRs; Region: SDR_c; cd05233 357348012754 NAD(P) binding site [chemical binding]; other site 357348012755 active site 357348012756 Transcriptional regulators [Transcription]; Region: GntR; COG1802 357348012757 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 357348012758 FCD domain; Region: FCD; pfam07729 357348012759 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 357348012760 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 357348012761 putative ion selectivity filter; other site 357348012762 putative pore gating glutamate residue; other site 357348012763 H-type lectin domain; Region: H_lectin; pfam09458 357348012764 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 357348012765 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 357348012766 Phosphoesterase family; Region: Phosphoesterase; pfam04185 357348012767 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 357348012768 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 357348012769 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 357348012770 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 357348012771 active site 357348012772 phosphorylation site [posttranslational modification] 357348012773 intermolecular recognition site; other site 357348012774 dimerization interface [polypeptide binding]; other site 357348012775 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 357348012776 DNA binding residues [nucleotide binding] 357348012777 dimerization interface [polypeptide binding]; other site 357348012778 MarR family; Region: MarR_2; cl17246 357348012779 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 357348012780 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 357348012781 dimerization interface [polypeptide binding]; other site 357348012782 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 357348012783 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 357348012784 TM-ABC transporter signature motif; other site 357348012785 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 357348012786 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 357348012787 Uncharacterized conserved protein [Function unknown]; Region: COG5649 357348012788 p-hydroxycinnamoyl CoA hydratase/lyase; Validated; Region: PRK09120 357348012789 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 357348012790 substrate binding site [chemical binding]; other site 357348012791 oxyanion hole (OAH) forming residues; other site 357348012792 trimer interface [polypeptide binding]; other site 357348012793 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 357348012794 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 357348012795 NAD(P) binding site [chemical binding]; other site 357348012796 catalytic residues [active] 357348012797 feruloyl-CoA synthase; Reviewed; Region: PRK08180 357348012798 Feruloyl-CoA synthetase (FCS); Region: FCS; cd05921 357348012799 acyl-activating enzyme (AAE) consensus motif; other site 357348012800 putative active site [active] 357348012801 putative AMP binding site [chemical binding]; other site 357348012802 putative CoA binding site [chemical binding]; other site 357348012803 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 357348012804 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348012805 putative substrate translocation pore; other site 357348012806 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 357348012807 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 357348012808 trimer interface [polypeptide binding]; other site 357348012809 eyelet of channel; other site 357348012810 Tannase and feruloyl esterase; Region: Tannase; pfam07519 357348012811 Transcriptional regulator [Transcription]; Region: IclR; COG1414 357348012812 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 357348012813 Bacterial transcriptional regulator; Region: IclR; pfam01614 357348012814 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 357348012815 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 357348012816 ligand binding site [chemical binding]; other site 357348012817 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 357348012818 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 357348012819 Walker A/P-loop; other site 357348012820 ATP binding site [chemical binding]; other site 357348012821 Q-loop/lid; other site 357348012822 ABC transporter signature motif; other site 357348012823 Walker B; other site 357348012824 D-loop; other site 357348012825 H-loop/switch region; other site 357348012826 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 357348012827 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 357348012828 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 357348012829 TM-ABC transporter signature motif; other site 357348012830 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 357348012831 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 357348012832 Amidohydrolase; Region: Amidohydro_2; pfam04909 357348012833 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 357348012834 active site 357348012835 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 357348012836 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 357348012837 NAD binding site [chemical binding]; other site 357348012838 homotetramer interface [polypeptide binding]; other site 357348012839 homodimer interface [polypeptide binding]; other site 357348012840 active site 357348012841 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 357348012842 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 357348012843 short chain dehydrogenase; Provisional; Region: PRK08628 357348012844 classical (c) SDRs; Region: SDR_c; cd05233 357348012845 NAD(P) binding site [chemical binding]; other site 357348012846 active site 357348012847 Domain of unknown function (DUF718); Region: DUF718; cl01281 357348012848 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 357348012849 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 357348012850 trimer interface [polypeptide binding]; other site 357348012851 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 357348012852 YadA-like C-terminal region; Region: YadA; pfam03895 357348012853 H-NS histone family; Region: Histone_HNS; pfam00816 357348012854 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 357348012855 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 357348012856 Transcriptional regulator [Transcription]; Region: IclR; COG1414 357348012857 Bacterial transcriptional regulator; Region: IclR; pfam01614 357348012858 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 357348012859 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 357348012860 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 357348012861 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 357348012862 CoenzymeA binding site [chemical binding]; other site 357348012863 subunit interaction site [polypeptide binding]; other site 357348012864 PHB binding site; other site 357348012865 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 357348012866 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 357348012867 dimerization interface [polypeptide binding]; other site 357348012868 ligand binding site [chemical binding]; other site 357348012869 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 357348012870 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 357348012871 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 357348012872 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 357348012873 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 357348012874 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 357348012875 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 357348012876 metal binding site [ion binding]; metal-binding site 357348012877 active site 357348012878 I-site; other site 357348012879 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 357348012880 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 357348012881 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 357348012882 AsnC family; Region: AsnC_trans_reg; pfam01037 357348012883 aromatic amino acid transporter; Provisional; Region: PRK10238 357348012884 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 357348012885 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 357348012886 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348012887 homodimer interface [polypeptide binding]; other site 357348012888 catalytic residue [active] 357348012889 Protein of unknown function, DUF488; Region: DUF488; cl01246 357348012890 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 357348012891 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 357348012892 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 357348012893 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 357348012894 PAS fold; Region: PAS; pfam00989 357348012895 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 357348012896 putative active site [active] 357348012897 heme pocket [chemical binding]; other site 357348012898 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357348012899 ATP binding site [chemical binding]; other site 357348012900 G-X-G motif; other site 357348012901 Response regulator receiver domain; Region: Response_reg; pfam00072 357348012902 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348012903 active site 357348012904 phosphorylation site [posttranslational modification] 357348012905 intermolecular recognition site; other site 357348012906 dimerization interface [polypeptide binding]; other site 357348012907 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 357348012908 Transglycosylase; Region: Transgly; pfam00912 357348012909 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 357348012910 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 357348012911 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 357348012912 MG2 domain; Region: A2M_N; pfam01835 357348012913 Alpha-2-macroglobulin family; Region: A2M; pfam00207 357348012914 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 357348012915 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 357348012916 putative active site pocket [active] 357348012917 dimerization interface [polypeptide binding]; other site 357348012918 putative catalytic residue [active] 357348012919 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 357348012920 active site 357348012921 HIGH motif; other site 357348012922 nucleotide binding site [chemical binding]; other site 357348012923 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 357348012924 active site 357348012925 KMSKS motif; other site 357348012926 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 357348012927 tRNA binding surface [nucleotide binding]; other site 357348012928 anticodon binding site; other site 357348012929 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357348012930 S-adenosylmethionine binding site [chemical binding]; other site 357348012931 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 357348012932 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 357348012933 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 357348012934 substrate binding pocket [chemical binding]; other site 357348012935 active site 357348012936 iron coordination sites [ion binding]; other site 357348012937 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357348012938 S-adenosylmethionine binding site [chemical binding]; other site 357348012939 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 357348012940 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 357348012941 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 357348012942 catalytic residue [active] 357348012943 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 357348012944 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 357348012945 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 357348012946 putative monooxygenase; Reviewed; Region: PRK07045 357348012947 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 357348012948 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 357348012949 sequence-specific DNA binding site [nucleotide binding]; other site 357348012950 salt bridge; other site 357348012951 Cupin domain; Region: Cupin_2; pfam07883 357348012952 Protein of unknown function (DUF2964); Region: DUF2964; pfam11177 357348012953 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 357348012954 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 357348012955 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348012956 active site 357348012957 phosphorylation site [posttranslational modification] 357348012958 intermolecular recognition site; other site 357348012959 dimerization interface [polypeptide binding]; other site 357348012960 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 357348012961 DNA binding residues [nucleotide binding] 357348012962 dimerization interface [polypeptide binding]; other site 357348012963 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 357348012964 Ligand Binding Site [chemical binding]; other site 357348012965 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 357348012966 Ligand Binding Site [chemical binding]; other site 357348012967 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 357348012968 Ligand Binding Site [chemical binding]; other site 357348012969 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 357348012970 Ligand Binding Site [chemical binding]; other site 357348012971 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 357348012972 Ligand Binding Site [chemical binding]; other site 357348012973 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 357348012974 Ligand Binding Site [chemical binding]; other site 357348012975 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 357348012976 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 357348012977 catalytic Zn binding site [ion binding]; other site 357348012978 structural Zn binding site [ion binding]; other site 357348012979 NAD(P) binding site [chemical binding]; other site 357348012980 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 357348012981 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 357348012982 active site residue [active] 357348012983 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357348012984 NAD(P) binding site [chemical binding]; other site 357348012985 active site 357348012986 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 357348012987 Spore germination protein; Region: Spore_permease; cl17796 357348012988 DNA-binding protein H-NS [General function prediction only]; Region: Hns; COG2916 357348012989 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 357348012990 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 357348012991 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 357348012992 Flavin binding site [chemical binding]; other site 357348012993 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 357348012994 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 357348012995 Protein of unknown function (DUF3088); Region: DUF3088; pfam11287 357348012996 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 357348012997 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 357348012998 active site 357348012999 non-prolyl cis peptide bond; other site 357348013000 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 357348013001 active site 357348013002 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 357348013003 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 357348013004 substrate binding site [chemical binding]; other site 357348013005 dimer interface [polypeptide binding]; other site 357348013006 ATP binding site [chemical binding]; other site 357348013007 This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990 357348013008 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 357348013009 DEAD_2; Region: DEAD_2; pfam06733 357348013010 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 357348013011 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 357348013012 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 357348013013 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 357348013014 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 357348013015 flagellar capping protein; Reviewed; Region: fliD; PRK08032 357348013016 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 357348013017 transcriptional regulator; Provisional; Region: PRK10632 357348013018 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348013019 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 357348013020 putative effector binding pocket; other site 357348013021 dimerization interface [polypeptide binding]; other site 357348013022 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 357348013023 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 357348013024 catalytic residues [active] 357348013025 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 357348013026 dimerization interface [polypeptide binding]; other site 357348013027 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 357348013028 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 357348013029 active site 357348013030 catalytic tetrad [active] 357348013031 Molybdenum cofactor biosynthesis protein F; Region: MoaF; pfam10703 357348013032 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 357348013033 classical (c) SDRs; Region: SDR_c; cd05233 357348013034 NAD(P) binding site [chemical binding]; other site 357348013035 active site 357348013036 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 357348013037 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 357348013038 DNA binding residues [nucleotide binding] 357348013039 dimerization interface [polypeptide binding]; other site 357348013040 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 357348013041 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 357348013042 NAD(P) binding site [chemical binding]; other site 357348013043 catalytic residues [active] 357348013044 hypothetical protein; Provisional; Region: PRK07481 357348013045 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 357348013046 inhibitor-cofactor binding pocket; inhibition site 357348013047 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348013048 catalytic residue [active] 357348013049 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 357348013050 Protein of unknown function (DUF3156); Region: DUF3156; pfam11354 357348013051 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357348013052 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357348013053 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 357348013054 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 357348013055 eyelet of channel; other site 357348013056 trimer interface [polypeptide binding]; other site 357348013057 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 357348013058 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357348013059 Coenzyme A binding pocket [chemical binding]; other site 357348013060 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 357348013061 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 357348013062 FMN binding site [chemical binding]; other site 357348013063 active site 357348013064 substrate binding site [chemical binding]; other site 357348013065 catalytic residue [active] 357348013066 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 357348013067 putative DNA binding site [nucleotide binding]; other site 357348013068 dimerization interface [polypeptide binding]; other site 357348013069 putative Zn2+ binding site [ion binding]; other site 357348013070 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 357348013071 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 357348013072 trimer interface [polypeptide binding]; other site 357348013073 eyelet of channel; other site 357348013074 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 357348013075 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 357348013076 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 357348013077 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 357348013078 FOG: CBS domain [General function prediction only]; Region: COG0517 357348013079 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 357348013080 dimerization interface [polypeptide binding]; other site 357348013081 active site 357348013082 Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205 357348013083 NADH/NADPH cofactor binding site [chemical binding]; other site 357348013084 Autoinducer synthetase; Region: Autoind_synth; cl17404 357348013085 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 357348013086 Autoinducer binding domain; Region: Autoind_bind; pfam03472 357348013087 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 357348013088 DNA binding residues [nucleotide binding] 357348013089 dimerization interface [polypeptide binding]; other site 357348013090 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 357348013091 MgtC family; Region: MgtC; pfam02308 357348013092 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 357348013093 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 357348013094 putative active site [active] 357348013095 putative metal binding site [ion binding]; other site 357348013096 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 357348013097 putative FMN binding site [chemical binding]; other site 357348013098 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 357348013099 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 357348013100 Transcriptional regulator [Transcription]; Region: IclR; COG1414 357348013101 Bacterial transcriptional regulator; Region: IclR; pfam01614 357348013102 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 357348013103 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 357348013104 trimer interface [polypeptide binding]; other site 357348013105 eyelet of channel; other site 357348013106 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 357348013107 [2Fe-2S] cluster binding site [ion binding]; other site 357348013108 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 357348013109 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 357348013110 [2Fe-2S] cluster binding site [ion binding]; other site 357348013111 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 357348013112 hydrophobic ligand binding site; other site 357348013113 short chain dehydrogenase; Provisional; Region: PRK12939 357348013114 classical (c) SDRs; Region: SDR_c; cd05233 357348013115 NAD(P) binding site [chemical binding]; other site 357348013116 active site 357348013117 Cupin domain; Region: Cupin_2; pfam07883 357348013118 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 357348013119 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 357348013120 Transcriptional regulator [Transcription]; Region: IclR; COG1414 357348013121 Bacterial transcriptional regulator; Region: IclR; pfam01614 357348013122 short chain dehydrogenase; Provisional; Region: PRK07062 357348013123 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 357348013124 putative NAD(P) binding site [chemical binding]; other site 357348013125 putative active site [active] 357348013126 hypothetical protein; Provisional; Region: PRK07064 357348013127 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 357348013128 PYR/PP interface [polypeptide binding]; other site 357348013129 dimer interface [polypeptide binding]; other site 357348013130 TPP binding site [chemical binding]; other site 357348013131 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 357348013132 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 357348013133 TPP-binding site [chemical binding]; other site 357348013134 L-aspartate dehydrogenase; Provisional; Region: PRK13303 357348013135 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 357348013136 Domain of unknown function DUF108; Region: DUF108; pfam01958 357348013137 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 357348013138 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 357348013139 NAD(P) binding site [chemical binding]; other site 357348013140 catalytic residues [active] 357348013141 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 357348013142 active site 357348013143 metal binding site [ion binding]; metal-binding site 357348013144 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 357348013145 C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360 357348013146 putative active site [active] 357348013147 putative metal binding site [ion binding]; other site 357348013148 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 357348013149 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 357348013150 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 357348013151 benzoate transport; Region: 2A0115; TIGR00895 357348013152 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348013153 putative substrate translocation pore; other site 357348013154 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348013155 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 357348013156 trimer interface [polypeptide binding]; other site 357348013157 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 357348013158 trimer interface [polypeptide binding]; other site 357348013159 Haemagglutinin; Region: HIM; pfam05662 357348013160 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 357348013161 trimer interface [polypeptide binding]; other site 357348013162 Haemagglutinin; Region: HIM; pfam05662 357348013163 Haemagglutinin; Region: HIM; pfam05662 357348013164 YadA-like C-terminal region; Region: YadA; pfam03895 357348013165 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 357348013166 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 357348013167 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 357348013168 ligand binding site [chemical binding]; other site 357348013169 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 357348013170 Ligand Binding Site [chemical binding]; other site 357348013171 amidase; Provisional; Region: PRK07486 357348013172 Amidase; Region: Amidase; pfam01425 357348013173 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 357348013174 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 357348013175 dimerization interface [polypeptide binding]; other site 357348013176 putative DNA binding site [nucleotide binding]; other site 357348013177 putative Zn2+ binding site [ion binding]; other site 357348013178 AsnC family; Region: AsnC_trans_reg; pfam01037 357348013179 methionine gamma-lyase; Validated; Region: PRK07049 357348013180 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 357348013181 homodimer interface [polypeptide binding]; other site 357348013182 substrate-cofactor binding pocket; other site 357348013183 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348013184 catalytic residue [active] 357348013185 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 357348013186 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 357348013187 Predicted transcriptional regulator [Transcription]; Region: COG1959 357348013188 Transcriptional regulator; Region: Rrf2; pfam02082 357348013189 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 357348013190 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 357348013191 putative transposase OrfB; Reviewed; Region: PHA02517 357348013192 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357348013193 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348013194 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 357348013195 dimerization interface [polypeptide binding]; other site 357348013196 hypothetical protein; Provisional; Region: PRK07079 357348013197 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679 357348013198 metal binding site [ion binding]; metal-binding site 357348013199 putative dimer interface [polypeptide binding]; other site 357348013200 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348013201 metabolite-proton symporter; Region: 2A0106; TIGR00883 357348013202 putative substrate translocation pore; other site 357348013203 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 357348013204 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 357348013205 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 357348013206 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 357348013207 short chain dehydrogenase; Provisional; Region: PRK07832 357348013208 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357348013209 NAD(P) binding site [chemical binding]; other site 357348013210 active site 357348013211 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 357348013212 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 357348013213 YhhN-like protein; Region: YhhN; pfam07947 357348013214 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 357348013215 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 357348013216 substrate binding pocket [chemical binding]; other site 357348013217 membrane-bound complex binding site; other site 357348013218 hinge residues; other site 357348013219 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg2; cd04778 357348013220 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 357348013221 DNA binding residues [nucleotide binding] 357348013222 putative dimer interface [polypeptide binding]; other site 357348013223 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 357348013224 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357348013225 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 357348013226 Coenzyme A binding pocket [chemical binding]; other site 357348013227 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 357348013228 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348013229 putative substrate translocation pore; other site 357348013230 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 357348013231 Tar ligand binding domain homologue; Region: TarH; pfam02203 357348013232 dimer interface [polypeptide binding]; other site 357348013233 ligand binding site [chemical binding]; other site 357348013234 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 357348013235 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 357348013236 dimerization interface [polypeptide binding]; other site 357348013237 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 357348013238 dimer interface [polypeptide binding]; other site 357348013239 putative CheW interface [polypeptide binding]; other site 357348013240 Family description; Region: UvrD_C_2; pfam13538 357348013241 BetR domain; Region: BetR; pfam08667 357348013242 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348013243 active site 357348013244 phosphorylation site [posttranslational modification] 357348013245 intermolecular recognition site; other site 357348013246 dimerization interface [polypeptide binding]; other site 357348013247 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 357348013248 hydroxyglutarate oxidase; Provisional; Region: PRK11728 357348013249 Ion channel; Region: Ion_trans_2; pfam07885 357348013250 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 357348013251 TrkA-N domain; Region: TrkA_N; pfam02254 357348013252 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 357348013253 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 357348013254 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 357348013255 ornithine cyclodeaminase; Validated; Region: PRK07340 357348013256 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 357348013257 Putative esterase; Region: Esterase; pfam00756 357348013258 OpgC protein; Region: OpgC_C; pfam10129 357348013259 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 357348013260 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 357348013261 trimer interface [polypeptide binding]; other site 357348013262 eyelet of channel; other site 357348013263 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357348013264 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348013265 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 357348013266 putative dimerization interface [polypeptide binding]; other site 357348013267 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 357348013268 Peptidase family M23; Region: Peptidase_M23; pfam01551 357348013269 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 357348013270 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 357348013271 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348013272 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 357348013273 substrate binding pocket [chemical binding]; other site 357348013274 dimerization interface [polypeptide binding]; other site 357348013275 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 357348013276 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 357348013277 Walker A/P-loop; other site 357348013278 ATP binding site [chemical binding]; other site 357348013279 Q-loop/lid; other site 357348013280 ABC transporter signature motif; other site 357348013281 Walker B; other site 357348013282 D-loop; other site 357348013283 H-loop/switch region; other site 357348013284 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 357348013285 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 357348013286 Walker A/P-loop; other site 357348013287 ATP binding site [chemical binding]; other site 357348013288 Q-loop/lid; other site 357348013289 ABC transporter signature motif; other site 357348013290 Walker B; other site 357348013291 D-loop; other site 357348013292 H-loop/switch region; other site 357348013293 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 357348013294 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348013295 dimer interface [polypeptide binding]; other site 357348013296 conserved gate region; other site 357348013297 putative PBP binding loops; other site 357348013298 ABC-ATPase subunit interface; other site 357348013299 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 357348013300 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348013301 dimer interface [polypeptide binding]; other site 357348013302 conserved gate region; other site 357348013303 putative PBP binding loops; other site 357348013304 ABC-ATPase subunit interface; other site 357348013305 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 357348013306 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 357348013307 D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178 357348013308 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 357348013309 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 357348013310 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 357348013311 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 357348013312 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 357348013313 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 357348013314 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 357348013315 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 357348013316 PAAR motif; Region: PAAR_motif; pfam05488 357348013317 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 357348013318 RHS Repeat; Region: RHS_repeat; cl11982 357348013319 RHS Repeat; Region: RHS_repeat; pfam05593 357348013320 RHS Repeat; Region: RHS_repeat; cl11982 357348013321 RHS Repeat; Region: RHS_repeat; pfam05593 357348013322 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 357348013323 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 357348013324 RHS Repeat; Region: RHS_repeat; pfam05593 357348013325 RHS Repeat; Region: RHS_repeat; cl11982 357348013326 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 357348013327 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 357348013328 catalytic triad [active] 357348013329 putative active site [active] 357348013330 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 357348013331 Autotransporter beta-domain; Region: Autotransporter; smart00869 357348013332 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 357348013333 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 357348013334 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 357348013335 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 357348013336 Cupin; Region: Cupin_1; smart00835 357348013337 Cupin; Region: Cupin_1; smart00835 357348013338 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 357348013339 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 357348013340 Predicted membrane protein [Function unknown]; Region: COG4682 357348013341 yiaA/B two helix domain; Region: YiaAB; pfam05360 357348013342 yiaA/B two helix domain; Region: YiaAB; pfam05360 357348013343 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 357348013344 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 357348013345 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 357348013346 putative molybdopterin cofactor binding site [chemical binding]; other site 357348013347 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 357348013348 putative molybdopterin cofactor binding site; other site 357348013349 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 357348013350 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 357348013351 DNA-binding site [nucleotide binding]; DNA binding site 357348013352 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 357348013353 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348013354 homodimer interface [polypeptide binding]; other site 357348013355 catalytic residue [active] 357348013356 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 357348013357 magnesium-transporting ATPase; Provisional; Region: PRK15122 357348013358 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 357348013359 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 357348013360 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 357348013361 Soluble P-type ATPase [General function prediction only]; Region: COG4087 357348013362 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 357348013363 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 357348013364 active site 357348013365 catalytic triad [active] 357348013366 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 357348013367 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 357348013368 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 357348013369 Cytochrome c; Region: Cytochrom_C; pfam00034 357348013370 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 357348013371 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 357348013372 Cytochrome c; Region: Cytochrom_C; pfam00034 357348013373 Predicted membrane protein [Function unknown]; Region: COG2259 357348013374 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 357348013375 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 357348013376 trimer interface [polypeptide binding]; other site 357348013377 eyelet of channel; other site 357348013378 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 357348013379 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 357348013380 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348013381 dimer interface [polypeptide binding]; other site 357348013382 conserved gate region; other site 357348013383 putative PBP binding loops; other site 357348013384 ABC-ATPase subunit interface; other site 357348013385 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348013386 dimer interface [polypeptide binding]; other site 357348013387 conserved gate region; other site 357348013388 putative PBP binding loops; other site 357348013389 ABC-ATPase subunit interface; other site 357348013390 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 357348013391 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 357348013392 Walker A/P-loop; other site 357348013393 ATP binding site [chemical binding]; other site 357348013394 Q-loop/lid; other site 357348013395 ABC transporter signature motif; other site 357348013396 Walker B; other site 357348013397 D-loop; other site 357348013398 H-loop/switch region; other site 357348013399 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 357348013400 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 357348013401 putative active site [active] 357348013402 Uncharacterized conserved protein [Function unknown]; Region: COG3791 357348013403 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348013404 putative substrate translocation pore; other site 357348013405 Histidine kinase; Region: His_kinase; pfam06580 357348013406 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357348013407 ATP binding site [chemical binding]; other site 357348013408 Mg2+ binding site [ion binding]; other site 357348013409 G-X-G motif; other site 357348013410 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348013411 Response regulator receiver domain; Region: Response_reg; pfam00072 357348013412 active site 357348013413 phosphorylation site [posttranslational modification] 357348013414 intermolecular recognition site; other site 357348013415 dimerization interface [polypeptide binding]; other site 357348013416 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 357348013417 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 357348013418 tetramer interface [polypeptide binding]; other site 357348013419 heme binding pocket [chemical binding]; other site 357348013420 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357348013421 Methyltransferase domain; Region: Methyltransf_31; pfam13847 357348013422 S-adenosylmethionine binding site [chemical binding]; other site 357348013423 Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119 357348013424 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357348013425 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 357348013426 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 357348013427 iron-sulfur cluster [ion binding]; other site 357348013428 [2Fe-2S] cluster binding site [ion binding]; other site 357348013429 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 357348013430 hydrophobic ligand binding site; other site 357348013431 TPR repeat; Region: TPR_11; pfam13414 357348013432 polyketide beta-ketoacyl:acyl carrier protein synthase; Validated; Region: PRK07103 357348013433 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 357348013434 dimer interface [polypeptide binding]; other site 357348013435 active site 357348013436 acyl carrier protein; Validated; Region: PRK07117 357348013437 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 357348013438 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 357348013439 substrate binding site [chemical binding]; other site 357348013440 oxyanion hole (OAH) forming residues; other site 357348013441 trimer interface [polypeptide binding]; other site 357348013442 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 357348013443 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 357348013444 substrate binding site [chemical binding]; other site 357348013445 oxyanion hole (OAH) forming residues; other site 357348013446 trimer interface [polypeptide binding]; other site 357348013447 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 357348013448 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 357348013449 dimer interface [polypeptide binding]; other site 357348013450 active site 357348013451 Transposase; Region: DEDD_Tnp_IS110; pfam01548 357348013452 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 357348013453 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 357348013454 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 357348013455 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 357348013456 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 357348013457 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 357348013458 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 357348013459 active site 357348013460 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 357348013461 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 357348013462 KR domain; Region: KR; pfam08659 357348013463 putative NADP binding site [chemical binding]; other site 357348013464 active site 357348013465 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 357348013466 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 357348013467 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 357348013468 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 357348013469 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 357348013470 catalytic residue [active] 357348013471 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 357348013472 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 357348013473 active site 357348013474 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 357348013475 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 357348013476 active site 357348013477 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 357348013478 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 357348013479 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 357348013480 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 357348013481 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 357348013482 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 357348013483 active site 357348013484 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 357348013485 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 357348013486 putative NADP binding site [chemical binding]; other site 357348013487 KR domain; Region: KR; pfam08659 357348013488 active site 357348013489 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 357348013490 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 357348013491 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 357348013492 active site 357348013493 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 357348013494 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 357348013495 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 357348013496 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 357348013497 active site 357348013498 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357348013499 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 357348013500 NAD(P) binding site [chemical binding]; other site 357348013501 Methyltransferase domain; Region: Methyltransf_12; pfam08242 357348013502 Methyltransferase domain; Region: Methyltransf_23; pfam13489 357348013503 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 357348013504 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 357348013505 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 357348013506 active site 357348013507 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 357348013508 Condensation domain; Region: Condensation; pfam00668 357348013509 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 357348013510 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 357348013511 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 357348013512 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 357348013513 acyl-activating enzyme (AAE) consensus motif; other site 357348013514 AMP binding site [chemical binding]; other site 357348013515 active site 357348013516 CoA binding site [chemical binding]; other site 357348013517 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 357348013518 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 357348013519 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 357348013520 active site 357348013521 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 357348013522 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357348013523 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 357348013524 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 357348013525 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 357348013526 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 357348013527 active site 357348013528 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 357348013529 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 357348013530 putative NADP binding site [chemical binding]; other site 357348013531 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 357348013532 active site 357348013533 Methyltransferase domain; Region: Methyltransf_23; pfam13489 357348013534 Methyltransferase domain; Region: Methyltransf_12; pfam08242 357348013535 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 357348013536 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 357348013537 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 357348013538 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 357348013539 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 357348013540 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 357348013541 catalytic residue [active] 357348013542 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 357348013543 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 357348013544 active site 357348013545 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 357348013546 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 357348013547 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 357348013548 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 357348013549 Cl- selectivity filter; other site 357348013550 Cl- binding residues [ion binding]; other site 357348013551 pore gating glutamate residue; other site 357348013552 FOG: CBS domain [General function prediction only]; Region: COG0517 357348013553 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 357348013554 MarR family; Region: MarR_2; pfam12802 357348013555 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 357348013556 HPP family; Region: HPP; pfam04982 357348013557 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 357348013558 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357348013559 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348013560 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 357348013561 putative effector binding pocket; other site 357348013562 dimerization interface [polypeptide binding]; other site 357348013563 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 357348013564 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 357348013565 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 357348013566 CAAX protease self-immunity; Region: Abi; cl00558 357348013567 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 357348013568 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 357348013569 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357348013570 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357348013571 RNA polymerase sigma factor; Provisional; Region: PRK12547 357348013572 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 357348013573 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 357348013574 DNA binding residues [nucleotide binding] 357348013575 YceI-like domain; Region: YceI; pfam04264 357348013576 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 357348013577 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 357348013578 RNA polymerase sigma factor; Provisional; Region: PRK12528 357348013579 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 357348013580 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 357348013581 DNA binding residues [nucleotide binding] 357348013582 fec operon regulator FecR; Reviewed; Region: PRK09774 357348013583 FecR protein; Region: FecR; pfam04773 357348013584 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 357348013585 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 357348013586 N-terminal plug; other site 357348013587 ligand-binding site [chemical binding]; other site 357348013588 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 357348013589 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 357348013590 TM-ABC transporter signature motif; other site 357348013591 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 357348013592 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 357348013593 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 357348013594 Walker A/P-loop; other site 357348013595 ATP binding site [chemical binding]; other site 357348013596 Q-loop/lid; other site 357348013597 ABC transporter signature motif; other site 357348013598 Walker B; other site 357348013599 D-loop; other site 357348013600 H-loop/switch region; other site 357348013601 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 357348013602 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 357348013603 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 357348013604 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 357348013605 putative ligand binding site [chemical binding]; other site 357348013606 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 357348013607 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 357348013608 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 357348013609 active site 357348013610 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 357348013611 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348013612 putative substrate translocation pore; other site 357348013613 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 357348013614 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 357348013615 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 357348013616 dimerization interface [polypeptide binding]; other site 357348013617 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357348013618 dimer interface [polypeptide binding]; other site 357348013619 phosphorylation site [posttranslational modification] 357348013620 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357348013621 ATP binding site [chemical binding]; other site 357348013622 Mg2+ binding site [ion binding]; other site 357348013623 G-X-G motif; other site 357348013624 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 357348013625 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348013626 active site 357348013627 phosphorylation site [posttranslational modification] 357348013628 intermolecular recognition site; other site 357348013629 dimerization interface [polypeptide binding]; other site 357348013630 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357348013631 DNA binding site [nucleotide binding] 357348013632 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 357348013633 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 357348013634 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 357348013635 HlyD family secretion protein; Region: HlyD_3; pfam13437 357348013636 Outer membrane efflux protein; Region: OEP; pfam02321 357348013637 Outer membrane efflux protein; Region: OEP; pfam02321 357348013638 Adenosine specific kinase; Region: Adenosine_kin; pfam04008 357348013639 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 357348013640 putative deacylase active site [active] 357348013641 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 357348013642 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 357348013643 hexamer interface [polypeptide binding]; other site 357348013644 ligand binding site [chemical binding]; other site 357348013645 putative active site [active] 357348013646 NAD(P) binding site [chemical binding]; other site 357348013647 H-NS histone family; Region: Histone_HNS; pfam00816 357348013648 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 357348013649 ProQ/FINO family; Region: ProQ; pfam04352 357348013650 Activator of osmoprotectant transporter ProP [Signal transduction mechanisms]; Region: ProQ; COG3109 357348013651 putative RNA binding sites [nucleotide binding]; other site 357348013652 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 357348013653 Domain of unknown function (DUF2760); Region: DUF2760; pfam10816 357348013654 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 357348013655 nucleotide binding site [chemical binding]; other site 357348013656 putative NEF/HSP70 interaction site [polypeptide binding]; other site 357348013657 SBD interface [polypeptide binding]; other site 357348013658 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 357348013659 nucleotide binding site [chemical binding]; other site 357348013660 putative NEF/HSP70 interaction site [polypeptide binding]; other site 357348013661 SBD interface [polypeptide binding]; other site 357348013662 DNA-K related protein; Region: DUF3731; pfam12531 357348013663 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 357348013664 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 357348013665 putative active site [active] 357348013666 putative metal binding site [ion binding]; other site 357348013667 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 357348013668 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 357348013669 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 357348013670 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 357348013671 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 357348013672 Soluble P-type ATPase [General function prediction only]; Region: COG4087 357348013673 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 357348013674 Methyltransferase domain; Region: Methyltransf_31; pfam13847 357348013675 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357348013676 S-adenosylmethionine binding site [chemical binding]; other site 357348013677 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 357348013678 Mannan-binding protein; Region: MVL; pfam12151 357348013679 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 357348013680 dimer interface [polypeptide binding]; other site 357348013681 substrate binding site [chemical binding]; other site 357348013682 ATP binding site [chemical binding]; other site 357348013683 Methyltransferase domain; Region: Methyltransf_11; pfam08241 357348013684 Thymidylate synthase; Region: Thymidylat_synt; pfam00303 357348013685 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 357348013686 dimerization interface [polypeptide binding]; other site 357348013687 active site 357348013688 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 357348013689 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 357348013690 nudix motif; other site 357348013691 Methyltransferase domain; Region: Methyltransf_31; pfam13847 357348013692 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357348013693 S-adenosylmethionine binding site [chemical binding]; other site 357348013694 Protein of unknown function (DUF971); Region: DUF971; cl01414 357348013695 gamma-butyrobetaine hydroxylase; Region: carnitine_bodg; TIGR02409 357348013696 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 357348013697 substrate binding pocket [chemical binding]; other site 357348013698 active site 357348013699 iron coordination sites [ion binding]; other site 357348013700 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 357348013701 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 357348013702 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 357348013703 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 357348013704 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357348013705 Walker A motif; other site 357348013706 ATP binding site [chemical binding]; other site 357348013707 Walker B motif; other site 357348013708 arginine finger; other site 357348013709 Peptidase family M41; Region: Peptidase_M41; pfam01434 357348013710 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 357348013711 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 357348013712 active site 357348013713 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 357348013714 Predicted transcriptional regulator [Transcription]; Region: COG2345 357348013715 MarR family; Region: MarR_2; pfam12802 357348013716 Transcriptional regulator PadR-like family; Region: PadR; cl17335 357348013717 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 357348013718 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 357348013719 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 357348013720 HlyD family secretion protein; Region: HlyD_3; pfam13437 357348013721 multidrug efflux protein; Reviewed; Region: PRK09579 357348013722 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 357348013723 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 357348013724 dimerization interface [polypeptide binding]; other site 357348013725 active site 357348013726 FOG: WD40 repeat [General function prediction only]; Region: COG2319 357348013727 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 357348013728 structural tetrad; other site 357348013729 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 357348013730 structural tetrad; other site 357348013731 FOG: WD40 repeat [General function prediction only]; Region: COG2319 357348013732 Methyltransferase domain; Region: Methyltransf_23; pfam13489 357348013733 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357348013734 S-adenosylmethionine binding site [chemical binding]; other site 357348013735 Uncharacterized conserved protein [Function unknown]; Region: COG1262 357348013736 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 357348013737 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 357348013738 catalytic motif [active] 357348013739 Zn binding site [ion binding]; other site 357348013740 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 357348013741 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357348013742 S-adenosylmethionine binding site [chemical binding]; other site 357348013743 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 357348013744 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 357348013745 active site 357348013746 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348013747 putative substrate translocation pore; other site 357348013748 Predicted small integral membrane protein (DUF2165); Region: DUF2165; cl02290 357348013749 PAS fold; Region: PAS_4; pfam08448 357348013750 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 357348013751 DNA binding residues [nucleotide binding] 357348013752 dimerization interface [polypeptide binding]; other site 357348013753 SnoaL-like domain; Region: SnoaL_2; pfam12680 357348013754 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 357348013755 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 357348013756 active site 357348013757 FMN binding site [chemical binding]; other site 357348013758 2,4-decadienoyl-CoA binding site; other site 357348013759 catalytic residue [active] 357348013760 4Fe-4S cluster binding site [ion binding]; other site 357348013761 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 357348013762 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 357348013763 Predicted transcriptional regulators [Transcription]; Region: COG1695 357348013764 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 357348013765 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 357348013766 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 357348013767 substrate binding site [chemical binding]; other site 357348013768 multimerization interface [polypeptide binding]; other site 357348013769 ATP binding site [chemical binding]; other site 357348013770 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 357348013771 substrate binding pocket [chemical binding]; other site 357348013772 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 357348013773 active site 357348013774 iron coordination sites [ion binding]; other site 357348013775 Membrane transport protein; Region: Mem_trans; cl09117 357348013776 Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191 357348013777 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 357348013778 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 357348013779 Ligand Binding Site [chemical binding]; other site 357348013780 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 357348013781 Ligand Binding Site [chemical binding]; other site 357348013782 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 357348013783 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 357348013784 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 357348013785 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 357348013786 hydrogenase 4 subunit F; Validated; Region: PRK06458 357348013787 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 357348013788 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899 357348013789 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 357348013790 NADH dehydrogenase; Region: NADHdh; cl00469 357348013791 hydrogenase 4 subunit B; Validated; Region: PRK06521 357348013792 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 357348013793 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 357348013794 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 357348013795 regulatory phosphorylation site [posttranslational modification]; other site 357348013796 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357348013797 S-adenosylmethionine binding site [chemical binding]; other site 357348013798 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 357348013799 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 357348013800 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348013801 putative substrate translocation pore; other site 357348013802 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 357348013803 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 357348013804 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 357348013805 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 357348013806 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 357348013807 4Fe-4S binding domain; Region: Fer4; cl02805 357348013808 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 357348013809 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 357348013810 [4Fe-4S] binding site [ion binding]; other site 357348013811 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 357348013812 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 357348013813 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 357348013814 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 357348013815 molybdopterin cofactor binding site; other site 357348013816 CHASE domain; Region: CHASE; cl01369 357348013817 PAS domain S-box; Region: sensory_box; TIGR00229 357348013818 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 357348013819 putative active site [active] 357348013820 heme pocket [chemical binding]; other site 357348013821 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 357348013822 Histidine kinase; Region: HisKA_3; pfam07730 357348013823 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357348013824 ATP binding site [chemical binding]; other site 357348013825 Mg2+ binding site [ion binding]; other site 357348013826 G-X-G motif; other site 357348013827 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 357348013828 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348013829 active site 357348013830 phosphorylation site [posttranslational modification] 357348013831 intermolecular recognition site; other site 357348013832 dimerization interface [polypeptide binding]; other site 357348013833 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 357348013834 DNA binding residues [nucleotide binding] 357348013835 dimerization interface [polypeptide binding]; other site 357348013836 Response regulator receiver domain; Region: Response_reg; pfam00072 357348013837 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348013838 active site 357348013839 phosphorylation site [posttranslational modification] 357348013840 intermolecular recognition site; other site 357348013841 dimerization interface [polypeptide binding]; other site 357348013842 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 357348013843 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 357348013844 ligand binding site [chemical binding]; other site 357348013845 flexible hinge region; other site 357348013846 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 357348013847 putative switch regulator; other site 357348013848 non-specific DNA interactions [nucleotide binding]; other site 357348013849 DNA binding site [nucleotide binding] 357348013850 sequence specific DNA binding site [nucleotide binding]; other site 357348013851 putative cAMP binding site [chemical binding]; other site 357348013852 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 357348013853 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 357348013854 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 357348013855 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 357348013856 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 357348013857 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348013858 putative substrate translocation pore; other site 357348013859 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 357348013860 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 357348013861 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 357348013862 Predicted membrane protein (DUF2070); Region: DUF2070; pfam09843 357348013863 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 357348013864 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 357348013865 active site 357348013866 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 357348013867 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 357348013868 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 357348013869 acyl-activating enzyme (AAE) consensus motif; other site 357348013870 AMP binding site [chemical binding]; other site 357348013871 active site 357348013872 CoA binding site [chemical binding]; other site 357348013873 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 357348013874 Condensation domain; Region: Condensation; pfam00668 357348013875 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 357348013876 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 357348013877 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 357348013878 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 357348013879 active site 357348013880 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 357348013881 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 357348013882 putative NADP binding site [chemical binding]; other site 357348013883 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357348013884 NAD(P) binding site [chemical binding]; other site 357348013885 active site 357348013886 active site 357348013887 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 357348013888 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 357348013889 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 357348013890 active site 357348013891 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 357348013892 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 357348013893 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357348013894 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 357348013895 NAD(P) binding site [chemical binding]; other site 357348013896 active site 357348013897 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 357348013898 Condensation domain; Region: Condensation; pfam00668 357348013899 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 357348013900 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 357348013901 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 357348013902 acyl-activating enzyme (AAE) consensus motif; other site 357348013903 AMP binding site [chemical binding]; other site 357348013904 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 357348013905 Condensation domain; Region: Condensation; pfam00668 357348013906 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 357348013907 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 357348013908 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 357348013909 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 357348013910 active site 357348013911 Zn binding site [ion binding]; other site 357348013912 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 357348013913 Autoinducer binding domain; Region: Autoind_bind; pfam03472 357348013914 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 357348013915 DNA binding residues [nucleotide binding] 357348013916 dimerization interface [polypeptide binding]; other site 357348013917 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 357348013918 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 357348013919 Autoinducer synthetase; Region: Autoind_synth; cl17404 357348013920 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 357348013921 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 357348013922 acyl-activating enzyme (AAE) consensus motif; other site 357348013923 AMP binding site [chemical binding]; other site 357348013924 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 357348013925 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 357348013926 shikimate transporter; Provisional; Region: PRK09952 357348013927 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 357348013928 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 357348013929 acyl-CoA synthetase; Validated; Region: PRK05850 357348013930 acyl-activating enzyme (AAE) consensus motif; other site 357348013931 active site 357348013932 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 357348013933 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 357348013934 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 357348013935 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 357348013936 catalytic residue [active] 357348013937 Condensation domain; Region: Condensation; pfam00668 357348013938 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 357348013939 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 357348013940 acyl-activating enzyme (AAE) consensus motif; other site 357348013941 AMP binding site [chemical binding]; other site 357348013942 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 357348013943 Condensation domain; Region: Condensation; pfam00668 357348013944 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 357348013945 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 357348013946 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 357348013947 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 357348013948 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 357348013949 acyl-activating enzyme (AAE) consensus motif; other site 357348013950 AMP binding site [chemical binding]; other site 357348013951 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 357348013952 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 357348013953 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 357348013954 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 357348013955 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 357348013956 active site 357348013957 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 357348013958 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 357348013959 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 357348013960 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 357348013961 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 357348013962 catalytic residue [active] 357348013963 Condensation domain; Region: Condensation; pfam00668 357348013964 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 357348013965 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 357348013966 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 357348013967 acyl-activating enzyme (AAE) consensus motif; other site 357348013968 AMP binding site [chemical binding]; other site 357348013969 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 357348013970 Condensation domain; Region: Condensation; pfam00668 357348013971 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 357348013972 major capsid protein; Region: PHA00665 357348013973 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 357348013974 DNA-binding site [nucleotide binding]; DNA binding site 357348013975 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 357348013976 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 357348013977 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348013978 homodimer interface [polypeptide binding]; other site 357348013979 catalytic residue [active] 357348013980 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 357348013981 Uncharacterized conserved protein [Function unknown]; Region: COG2128 357348013982 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 357348013983 Predicted small secreted protein [Function unknown]; Region: COG5510 357348013984 aspartate carbamoyltransferase; Provisional; Region: PRK11891 357348013985 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 357348013986 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 357348013987 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 357348013988 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 357348013989 N-terminal plug; other site 357348013990 ligand-binding site [chemical binding]; other site 357348013991 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 357348013992 Sel1 repeat; Region: Sel1; cl02723 357348013993 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 357348013994 Transposase, Mutator family; Region: Transposase_mut; pfam00872 357348013995 Uncharacterized conserved protein [Function unknown]; Region: COG4104 357348013996 Protein of unknown function (DUF2875); Region: DUF2875; pfam11394 357348013997 Protein of unknown function (DUF3274); Region: DUF3274; pfam11678 357348013998 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 357348013999 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 357348014000 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 357348014001 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 357348014002 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253 357348014003 H-NS histone family; Region: Histone_HNS; pfam00816 357348014004 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 357348014005 metabolite-proton symporter; Region: 2A0106; TIGR00883 357348014006 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348014007 putative substrate translocation pore; other site 357348014008 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 357348014009 thiamine phosphate binding site [chemical binding]; other site 357348014010 active site 357348014011 pyrophosphate binding site [ion binding]; other site 357348014012 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 357348014013 metal-binding site 357348014014 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 357348014015 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 357348014016 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 357348014017 dimer interface [polypeptide binding]; other site 357348014018 putative CheW interface [polypeptide binding]; other site 357348014019 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 357348014020 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 357348014021 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 357348014022 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 357348014023 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 357348014024 ligand binding site [chemical binding]; other site 357348014025 short chain dehydrogenase; Provisional; Region: PRK07074 357348014026 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357348014027 NAD(P) binding site [chemical binding]; other site 357348014028 active site 357348014029 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 357348014030 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 357348014031 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 357348014032 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 357348014033 substrate binding pocket [chemical binding]; other site 357348014034 chain length determination region; other site 357348014035 substrate-Mg2+ binding site; other site 357348014036 catalytic residues [active] 357348014037 aspartate-rich region 1; other site 357348014038 active site lid residues [active] 357348014039 aspartate-rich region 2; other site 357348014040 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 357348014041 substrate binding pocket [chemical binding]; other site 357348014042 substrate-Mg2+ binding site; other site 357348014043 aspartate-rich region 1; other site 357348014044 aspartate-rich region 2; other site 357348014045 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 357348014046 putative cation:proton antiport protein; Provisional; Region: PRK10669 357348014047 TrkA-N domain; Region: TrkA_N; pfam02254 357348014048 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 357348014049 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 357348014050 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 357348014051 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 357348014052 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 357348014053 dimer interface [polypeptide binding]; other site 357348014054 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 357348014055 Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834 357348014056 Cl binding site [ion binding]; other site 357348014057 oligomer interface [polypeptide binding]; other site 357348014058 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 357348014059 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 357348014060 Electron transfer DM13; Region: DM13; pfam10517 357348014061 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 357348014062 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 357348014063 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 357348014064 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 357348014065 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348014066 dimer interface [polypeptide binding]; other site 357348014067 conserved gate region; other site 357348014068 putative PBP binding loops; other site 357348014069 ABC-ATPase subunit interface; other site 357348014070 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 357348014071 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 357348014072 inhibitor binding site; inhibition site 357348014073 catalytic Zn binding site [ion binding]; other site 357348014074 structural Zn binding site [ion binding]; other site 357348014075 NADP binding site [chemical binding]; other site 357348014076 tetramer interface [polypeptide binding]; other site 357348014077 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 357348014078 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357348014079 Walker A/P-loop; other site 357348014080 ATP binding site [chemical binding]; other site 357348014081 Q-loop/lid; other site 357348014082 ABC transporter signature motif; other site 357348014083 Walker B; other site 357348014084 D-loop; other site 357348014085 H-loop/switch region; other site 357348014086 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 357348014087 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 357348014088 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357348014089 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357348014090 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 357348014091 N- and C-terminal domain interface [polypeptide binding]; other site 357348014092 active site 357348014093 MgATP binding site [chemical binding]; other site 357348014094 catalytic site [active] 357348014095 metal binding site [ion binding]; metal-binding site 357348014096 xylulose binding site [chemical binding]; other site 357348014097 homodimer interface [polypeptide binding]; other site 357348014098 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 357348014099 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 357348014100 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 357348014101 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 357348014102 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 357348014103 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 357348014104 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 357348014105 [4Fe-4S] binding site [ion binding]; other site 357348014106 molybdopterin cofactor binding site; other site 357348014107 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 357348014108 molybdopterin cofactor binding site; other site 357348014109 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 357348014110 Flavodoxin; Region: Flavodoxin_1; pfam00258 357348014111 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 357348014112 FAD binding pocket [chemical binding]; other site 357348014113 FAD binding motif [chemical binding]; other site 357348014114 catalytic residues [active] 357348014115 NAD binding pocket [chemical binding]; other site 357348014116 phosphate binding motif [ion binding]; other site 357348014117 beta-alpha-beta structure motif; other site 357348014118 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 357348014119 nitrite reductase subunit NirD; Provisional; Region: PRK14989 357348014120 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 357348014121 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 357348014122 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 357348014123 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 357348014124 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 357348014125 active site 357348014126 SAM binding site [chemical binding]; other site 357348014127 homodimer interface [polypeptide binding]; other site 357348014128 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 357348014129 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348014130 active site 357348014131 phosphorylation site [posttranslational modification] 357348014132 intermolecular recognition site; other site 357348014133 dimerization interface [polypeptide binding]; other site 357348014134 ANTAR domain; Region: ANTAR; pfam03861 357348014135 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 357348014136 NMT1-like family; Region: NMT1_2; pfam13379 357348014137 GTP cyclohydrolase I; Reviewed; Region: PRK12606 357348014138 GTP cyclohydrolase I; Provisional; Region: PLN03044 357348014139 active site 357348014140 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 357348014141 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 357348014142 active site 357348014143 Zn binding site [ion binding]; other site 357348014144 allantoate amidohydrolase; Reviewed; Region: PRK12893 357348014145 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 357348014146 active site 357348014147 metal binding site [ion binding]; metal-binding site 357348014148 dimer interface [polypeptide binding]; other site 357348014149 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348014150 metabolite-proton symporter; Region: 2A0106; TIGR00883 357348014151 putative substrate translocation pore; other site 357348014152 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357348014153 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348014154 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 357348014155 dimerization interface [polypeptide binding]; other site 357348014156 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357348014157 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348014158 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 357348014159 putative effector binding pocket; other site 357348014160 putative dimerization interface [polypeptide binding]; other site 357348014161 short chain dehydrogenase; Provisional; Region: PRK12937 357348014162 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 357348014163 NADP binding site [chemical binding]; other site 357348014164 homodimer interface [polypeptide binding]; other site 357348014165 active site 357348014166 substrate binding site [chemical binding]; other site 357348014167 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 357348014168 CoA-transferase family III; Region: CoA_transf_3; pfam02515 357348014169 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 357348014170 Prostaglandin dehydrogenases; Region: PGDH; cd05288 357348014171 NAD(P) binding site [chemical binding]; other site 357348014172 substrate binding site [chemical binding]; other site 357348014173 dimer interface [polypeptide binding]; other site 357348014174 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 357348014175 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 357348014176 dimer interface [polypeptide binding]; other site 357348014177 active site 357348014178 metal binding site [ion binding]; metal-binding site 357348014179 Peptidase M66; Region: Peptidase_M66; pfam10462 357348014180 Uncharacterized protein conserved in bacteria (DUF2322); Region: DUF2322; pfam10084 357348014181 Protein of unknown function (DUF3348); Region: DUF3348; pfam11828 357348014182 Domain of unknown function (DUF802); Region: DUF802; pfam05650 357348014183 hypothetical protein; Provisional; Region: PRK09040 357348014184 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 357348014185 ligand binding site [chemical binding]; other site 357348014186 Protein of unknown function (DUF2894); Region: DUF2894; pfam11445 357348014187 Protein of unknown function (DUF2894); Region: DUF2894; pfam11445 357348014188 Condensation domain; Region: Condensation; pfam00668 357348014189 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 357348014190 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 357348014191 acyl-activating enzyme (AAE) consensus motif; other site 357348014192 AMP binding site [chemical binding]; other site 357348014193 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 357348014194 MbtH-like protein; Region: MbtH; pfam03621 357348014195 Major Facilitator Superfamily; Region: MFS_1; pfam07690 357348014196 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 357348014197 Condensation domain; Region: Condensation; pfam00668 357348014198 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 357348014199 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 357348014200 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 357348014201 acyl-activating enzyme (AAE) consensus motif; other site 357348014202 AMP binding site [chemical binding]; other site 357348014203 Condensation domain; Region: Condensation; pfam00668 357348014204 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 357348014205 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 357348014206 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 357348014207 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 357348014208 acyl-activating enzyme (AAE) consensus motif; other site 357348014209 AMP binding site [chemical binding]; other site 357348014210 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 357348014211 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 357348014212 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 357348014213 active site 357348014214 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 357348014215 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 357348014216 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 357348014217 KR domain; Region: KR; pfam08659 357348014218 putative NADP binding site [chemical binding]; other site 357348014219 active site 357348014220 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 357348014221 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 357348014222 Biofilm formation and stress response factor; Region: BsmA; pfam10014 357348014223 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 357348014224 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 357348014225 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 357348014226 active site 357348014227 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 357348014228 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 357348014229 active site 357348014230 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 357348014231 acyl-CoA synthetase; Validated; Region: PRK05850 357348014232 acyl-activating enzyme (AAE) consensus motif; other site 357348014233 active site 357348014234 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 357348014235 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 357348014236 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 357348014237 DNA binding residues [nucleotide binding] 357348014238 Uncharacterized conserved protein [Function unknown]; Region: COG1739 357348014239 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 357348014240 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 357348014241 EamA-like transporter family; Region: EamA; pfam00892 357348014242 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 357348014243 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 357348014244 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 357348014245 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 357348014246 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 357348014247 threonine dehydratase; Reviewed; Region: PRK09224 357348014248 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 357348014249 tetramer interface [polypeptide binding]; other site 357348014250 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348014251 catalytic residue [active] 357348014252 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 357348014253 putative Ile/Val binding site [chemical binding]; other site 357348014254 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 357348014255 putative Ile/Val binding site [chemical binding]; other site 357348014256 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 357348014257 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 357348014258 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 357348014259 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 357348014260 linker region; other site 357348014261 HlyD family secretion protein; Region: HlyD_3; pfam13437 357348014262 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 357348014263 putative acyl-acceptor binding pocket; other site 357348014264 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 357348014265 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 357348014266 putative active site [active] 357348014267 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 357348014268 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 357348014269 Walker A/P-loop; other site 357348014270 ATP binding site [chemical binding]; other site 357348014271 Q-loop/lid; other site 357348014272 ABC transporter signature motif; other site 357348014273 Walker B; other site 357348014274 D-loop; other site 357348014275 H-loop/switch region; other site 357348014276 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 357348014277 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 357348014278 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 357348014279 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 357348014280 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 357348014281 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 357348014282 ATP binding site [chemical binding]; other site 357348014283 putative Mg++ binding site [ion binding]; other site 357348014284 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 357348014285 nucleotide binding region [chemical binding]; other site 357348014286 ATP-binding site [chemical binding]; other site 357348014287 DEAD/H associated; Region: DEAD_assoc; pfam08494 357348014288 putative transporter; Provisional; Region: PRK11021 357348014289 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 357348014290 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 357348014291 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 357348014292 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 357348014293 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 357348014294 S-adenosylmethionine binding site [chemical binding]; other site 357348014295 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 357348014296 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 357348014297 metal binding site [ion binding]; metal-binding site 357348014298 active site 357348014299 I-site; other site 357348014300 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 357348014301 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348014302 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 357348014303 dimerization interface [polypeptide binding]; other site 357348014304 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 357348014305 heterodimer interface [polypeptide binding]; other site 357348014306 multimer interface [polypeptide binding]; other site 357348014307 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 357348014308 active site 357348014309 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 357348014310 active site 357348014311 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 357348014312 SxDxEG motif; other site 357348014313 active site 357348014314 metal binding site [ion binding]; metal-binding site 357348014315 homopentamer interface [polypeptide binding]; other site 357348014316 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 357348014317 homotetramer interface [polypeptide binding]; other site 357348014318 DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group represents...; Region: DmpA_OAT; cl00603 357348014319 cleavage site 357348014320 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 357348014321 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 357348014322 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348014323 dimer interface [polypeptide binding]; other site 357348014324 conserved gate region; other site 357348014325 putative PBP binding loops; other site 357348014326 ABC-ATPase subunit interface; other site 357348014327 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 357348014328 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348014329 dimer interface [polypeptide binding]; other site 357348014330 conserved gate region; other site 357348014331 putative PBP binding loops; other site 357348014332 ABC-ATPase subunit interface; other site 357348014333 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 357348014334 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 357348014335 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 357348014336 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 357348014337 Walker A/P-loop; other site 357348014338 ATP binding site [chemical binding]; other site 357348014339 Q-loop/lid; other site 357348014340 ABC transporter signature motif; other site 357348014341 Walker B; other site 357348014342 D-loop; other site 357348014343 H-loop/switch region; other site 357348014344 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 357348014345 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 357348014346 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 357348014347 Walker A/P-loop; other site 357348014348 ATP binding site [chemical binding]; other site 357348014349 Q-loop/lid; other site 357348014350 ABC transporter signature motif; other site 357348014351 Walker B; other site 357348014352 D-loop; other site 357348014353 H-loop/switch region; other site 357348014354 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 357348014355 Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked...; Region: Ntn_Asparaginase_2_like; cl00635 357348014356 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 357348014357 catalytic nucleophile [active] 357348014358 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 357348014359 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 357348014360 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 357348014361 putative active site [active] 357348014362 BCCT family transporter; Region: BCCT; pfam02028 357348014363 Beta-lactamase; Region: Beta-lactamase; pfam00144 357348014364 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 357348014365 Phosphoesterase family; Region: Phosphoesterase; pfam04185 357348014366 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 357348014367 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 357348014368 active site 357348014369 HIGH motif; other site 357348014370 nucleotide binding site [chemical binding]; other site 357348014371 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 357348014372 active site 357348014373 KMSKS motif; other site 357348014374 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 357348014375 tRNA binding surface [nucleotide binding]; other site 357348014376 anticodon binding site; other site 357348014377 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 357348014378 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 357348014379 EamA-like transporter family; Region: EamA; pfam00892 357348014380 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 357348014381 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 357348014382 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 357348014383 FAD binding domain; Region: FAD_binding_4; pfam01565 357348014384 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 357348014385 Methyltransferase domain; Region: Methyltransf_31; pfam13847 357348014386 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357348014387 S-adenosylmethionine binding site [chemical binding]; other site 357348014388 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 357348014389 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357348014390 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357348014391 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 357348014392 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 357348014393 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348014394 catalytic residue [active] 357348014395 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 357348014396 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 357348014397 putative DNA binding site [nucleotide binding]; other site 357348014398 putative Zn2+ binding site [ion binding]; other site 357348014399 AsnC family; Region: AsnC_trans_reg; pfam01037 357348014400 LabA_like proteins; Region: LabA_like; cd06167 357348014401 putative metal binding site [ion binding]; other site 357348014402 Uncharacterized conserved protein [Function unknown]; Region: COG1432 357348014403 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 357348014404 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348014405 putative substrate translocation pore; other site 357348014406 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 357348014407 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 357348014408 DNA-binding site [nucleotide binding]; DNA binding site 357348014409 UTRA domain; Region: UTRA; pfam07702 357348014410 benzoate transport; Region: 2A0115; TIGR00895 357348014411 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348014412 putative substrate translocation pore; other site 357348014413 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 357348014414 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 357348014415 active site 357348014416 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 357348014417 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 357348014418 active site 357348014419 metal binding site [ion binding]; metal-binding site 357348014420 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 357348014421 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 357348014422 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 357348014423 Protein of unknown function (DUF3079); Region: DUF3079; pfam11278 357348014424 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 357348014425 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357348014426 Coenzyme A binding pocket [chemical binding]; other site 357348014427 Predicted transporter component [General function prediction only]; Region: COG2391 357348014428 Sulphur transport; Region: Sulf_transp; pfam04143 357348014429 Predicted transporter component [General function prediction only]; Region: COG2391 357348014430 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 357348014431 dimerization interface [polypeptide binding]; other site 357348014432 putative DNA binding site [nucleotide binding]; other site 357348014433 putative Zn2+ binding site [ion binding]; other site 357348014434 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 357348014435 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 357348014436 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 357348014437 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 357348014438 catalytic residue [active] 357348014439 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 357348014440 non-specific DNA binding site [nucleotide binding]; other site 357348014441 salt bridge; other site 357348014442 sequence-specific DNA binding site [nucleotide binding]; other site 357348014443 serine O-acetyltransferase; Region: cysE; TIGR01172 357348014444 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 357348014445 trimer interface [polypeptide binding]; other site 357348014446 active site 357348014447 substrate binding site [chemical binding]; other site 357348014448 CoA binding site [chemical binding]; other site 357348014449 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 357348014450 active site residue [active] 357348014451 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 357348014452 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 357348014453 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 357348014454 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 357348014455 HlyD family secretion protein; Region: HlyD_3; pfam13437 357348014456 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 357348014457 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 357348014458 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 357348014459 Ligand binding site; other site 357348014460 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 357348014461 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348014462 putative substrate translocation pore; other site 357348014463 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348014464 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 357348014465 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 357348014466 active site 357348014467 TDP-binding site; other site 357348014468 acceptor substrate-binding pocket; other site 357348014469 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 357348014470 transcriptional regulator BetI; Validated; Region: PRK00767 357348014471 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 357348014472 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 357348014473 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 357348014474 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 357348014475 NAD(P) binding site [chemical binding]; other site 357348014476 catalytic residues [active] 357348014477 choline dehydrogenase; Validated; Region: PRK02106 357348014478 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 357348014479 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 357348014480 benzoate transport; Region: 2A0115; TIGR00895 357348014481 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348014482 putative substrate translocation pore; other site 357348014483 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348014484 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 357348014485 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348014486 active site 357348014487 phosphorylation site [posttranslational modification] 357348014488 intermolecular recognition site; other site 357348014489 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 357348014490 PAS fold; Region: PAS_3; pfam08447 357348014491 putative active site [active] 357348014492 heme pocket [chemical binding]; other site 357348014493 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 357348014494 Histidine kinase; Region: HisKA_3; pfam07730 357348014495 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357348014496 ATP binding site [chemical binding]; other site 357348014497 Mg2+ binding site [ion binding]; other site 357348014498 G-X-G motif; other site 357348014499 Response regulator receiver domain; Region: Response_reg; pfam00072 357348014500 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348014501 active site 357348014502 phosphorylation site [posttranslational modification] 357348014503 intermolecular recognition site; other site 357348014504 dimerization interface [polypeptide binding]; other site 357348014505 CHASE3 domain; Region: CHASE3; pfam05227 357348014506 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 357348014507 PAS domain; Region: PAS_9; pfam13426 357348014508 putative active site [active] 357348014509 heme pocket [chemical binding]; other site 357348014510 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 357348014511 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 357348014512 putative active site [active] 357348014513 heme pocket [chemical binding]; other site 357348014514 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357348014515 dimer interface [polypeptide binding]; other site 357348014516 phosphorylation site [posttranslational modification] 357348014517 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357348014518 ATP binding site [chemical binding]; other site 357348014519 Mg2+ binding site [ion binding]; other site 357348014520 G-X-G motif; other site 357348014521 OsmC-like protein; Region: OsmC; cl00767 357348014522 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 357348014523 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 357348014524 putative ligand binding site [chemical binding]; other site 357348014525 NAD binding site [chemical binding]; other site 357348014526 catalytic site [active] 357348014527 Protein of unknown function (DUF3761); Region: DUF3761; pfam12587 357348014528 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 357348014529 DNA-binding site [nucleotide binding]; DNA binding site 357348014530 RNA-binding motif; other site 357348014531 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 357348014532 Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539 357348014533 active site 357348014534 Sarcosine oxidase gamma subunit [Amino acid transport and metabolism]; Region: COG4583 357348014535 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 357348014536 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 357348014537 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 357348014538 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 357348014539 Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311 357348014540 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 357348014541 hydroxyglutarate oxidase; Provisional; Region: PRK11728 357348014542 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 357348014543 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 357348014544 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 357348014545 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 357348014546 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 357348014547 conserved cys residue [active] 357348014548 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357348014549 hypothetical protein; Provisional; Region: PRK11239 357348014550 Protein of unknown function, DUF480; Region: DUF480; pfam04337 357348014551 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 357348014552 C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases; Region: GST_C_Sigma_like; cd03192 357348014553 dimer interface [polypeptide binding]; other site 357348014554 N-terminal domain interface [polypeptide binding]; other site 357348014555 substrate binding pocket (H-site) [chemical binding]; other site 357348014556 Low affinity iron permease; Region: Iron_permease; pfam04120 357348014557 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 357348014558 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 357348014559 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 357348014560 Domain of unknown function (DUF305); Region: DUF305; pfam03713 357348014561 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 357348014562 MgtC family; Region: MgtC; pfam02308 357348014563 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 357348014564 putative active site [active] 357348014565 catalytic site [active] 357348014566 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 357348014567 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 357348014568 putative active site [active] 357348014569 catalytic site [active] 357348014570 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 357348014571 Uncharacterized conserved protein [Function unknown]; Region: COG0398 357348014572 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 357348014573 putative catalytic site [active] 357348014574 putative metal binding site [ion binding]; other site 357348014575 putative phosphate binding site [ion binding]; other site 357348014576 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 357348014577 type II secretion system protein D; Region: type_II_gspD; TIGR02517 357348014578 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 357348014579 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 357348014580 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 357348014581 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357348014582 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 357348014583 Bacterial type III secretion protein (HrpB7); Region: HrpB7; cl09720 357348014584 type III secretion system ATPase; Provisional; Region: PRK09099 357348014585 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 357348014586 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 357348014587 Walker A motif; other site 357348014588 ATP binding site [chemical binding]; other site 357348014589 Walker B motif; other site 357348014590 type III secretion system protein HrpB; Validated; Region: PRK09098 357348014591 Flagellar assembly protein FliH; Region: FliH; pfam02108 357348014592 type III secretion protein HrpB4; Region: HrpB4; TIGR02560 357348014593 Bacterial type III secretion protein (HrpB4); Region: HrpB4; pfam09502 357348014594 type III secretion apparatus lipoprotein, YscJ/HrcJ family; Region: III_secr_YscJ; TIGR02544 357348014595 type III secretion protein HrpB2; Region: HrpB2; TIGR02558 357348014596 type III secretion protein HrpB1/HrpK; Region: HrpB1_HrpK; TIGR02561 357348014597 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 357348014598 TPR motif; other site 357348014599 binding surface 357348014600 type III secretion system protein HrcU; Validated; Region: PRK09108 357348014601 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 357348014602 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 357348014603 FHIPEP family; Region: FHIPEP; pfam00771 357348014604 type III secretion protein HpaP; Region: HpaP; TIGR02557 357348014605 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 357348014606 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 357348014607 type III secretion system protein YscR; Provisional; Region: PRK12797 357348014608 Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794 357348014609 type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500 357348014610 Tir chaperone protein (CesT) family; Region: CesT; cl08444 357348014611 Cupin domain; Region: Cupin_2; cl17218 357348014612 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 357348014613 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 357348014614 Transcriptional regulators [Transcription]; Region: FadR; COG2186 357348014615 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 357348014616 DNA-binding site [nucleotide binding]; DNA binding site 357348014617 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 357348014618 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 357348014619 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 357348014620 putative aldolase; Validated; Region: PRK08130 357348014621 intersubunit interface [polypeptide binding]; other site 357348014622 active site 357348014623 Zn2+ binding site [ion binding]; other site 357348014624 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348014625 D-galactonate transporter; Region: 2A0114; TIGR00893 357348014626 putative substrate translocation pore; other site 357348014627 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 357348014628 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 357348014629 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 357348014630 putative NAD(P) binding site [chemical binding]; other site 357348014631 active site 357348014632 putative substrate binding site [chemical binding]; other site 357348014633 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 357348014634 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 357348014635 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 357348014636 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 357348014637 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 357348014638 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 357348014639 conserved cys residue [active] 357348014640 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357348014641 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348014642 dimer interface [polypeptide binding]; other site 357348014643 conserved gate region; other site 357348014644 putative PBP binding loops; other site 357348014645 ABC-ATPase subunit interface; other site 357348014646 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 357348014647 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 357348014648 Walker A/P-loop; other site 357348014649 ATP binding site [chemical binding]; other site 357348014650 Q-loop/lid; other site 357348014651 ABC transporter signature motif; other site 357348014652 Walker B; other site 357348014653 D-loop; other site 357348014654 H-loop/switch region; other site 357348014655 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 357348014656 Predicted flavoprotein [General function prediction only]; Region: COG0431 357348014657 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 357348014658 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 357348014659 dimerization interface [polypeptide binding]; other site 357348014660 putative DNA binding site [nucleotide binding]; other site 357348014661 putative Zn2+ binding site [ion binding]; other site 357348014662 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 357348014663 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 357348014664 putative metal binding site [ion binding]; other site 357348014665 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 357348014666 Low molecular weight phosphatase family; Region: LMWPc; cd00115 357348014667 active site 357348014668 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 357348014669 arsenical-resistance protein; Region: acr3; TIGR00832 357348014670 YadA-like C-terminal region; Region: YadA; pfam03895 357348014671 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357348014672 binding surface 357348014673 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 357348014674 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 357348014675 Haemagglutinin; Region: HIM; pfam05662 357348014676 YadA-like C-terminal region; Region: YadA; pfam03895 357348014677 Protein of unknown function (DUF2827); Region: DUF2827; pfam10933 357348014678 Protein of unknown function (DUF2827); Region: DUF2827; pfam10933 357348014679 Protein of unknown function (DUF2827); Region: DUF2827; pfam10933 357348014680 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 357348014681 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 357348014682 ATP-grasp domain; Region: ATP-grasp_4; cl17255 357348014683 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 357348014684 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 357348014685 carboxyltransferase (CT) interaction site; other site 357348014686 biotinylation site [posttranslational modification]; other site 357348014687 enoyl-CoA hydratase; Provisional; Region: PRK05995 357348014688 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 357348014689 substrate binding site [chemical binding]; other site 357348014690 oxyanion hole (OAH) forming residues; other site 357348014691 trimer interface [polypeptide binding]; other site 357348014692 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 357348014693 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 357348014694 isovaleryl-CoA dehydrogenase; Region: PLN02519 357348014695 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 357348014696 substrate binding site [chemical binding]; other site 357348014697 FAD binding site [chemical binding]; other site 357348014698 catalytic base [active] 357348014699 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 357348014700 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 357348014701 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 357348014702 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 357348014703 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 357348014704 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 357348014705 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 357348014706 Multicopper oxidase; Region: Cu-oxidase; pfam00394 357348014707 Cytochrome c; Region: Cytochrom_C; pfam00034 357348014708 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 357348014709 [2Fe-2S] cluster binding site [ion binding]; other site 357348014710 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 357348014711 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 357348014712 alpha subunit interface [polypeptide binding]; other site 357348014713 active site 357348014714 substrate binding site [chemical binding]; other site 357348014715 Fe binding site [ion binding]; other site 357348014716 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 357348014717 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 357348014718 dimer interface [polypeptide binding]; other site 357348014719 active site 357348014720 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 357348014721 catalytic residues [active] 357348014722 substrate binding site [chemical binding]; other site 357348014723 Protein of unknown function (DUF3326); Region: DUF3326; pfam11805 357348014724 Cupin-like domain; Region: Cupin_8; pfam13621 357348014725 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 357348014726 benzoate transport; Region: 2A0115; TIGR00895 357348014727 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348014728 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348014729 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 357348014730 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 357348014731 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 357348014732 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357348014733 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 357348014734 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 357348014735 dimer interface [polypeptide binding]; other site 357348014736 phosphorylation site [posttranslational modification] 357348014737 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357348014738 ATP binding site [chemical binding]; other site 357348014739 Mg2+ binding site [ion binding]; other site 357348014740 G-X-G motif; other site 357348014741 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 357348014742 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348014743 active site 357348014744 phosphorylation site [posttranslational modification] 357348014745 intermolecular recognition site; other site 357348014746 dimerization interface [polypeptide binding]; other site 357348014747 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357348014748 DNA binding site [nucleotide binding] 357348014749 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 357348014750 Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029 357348014751 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 357348014752 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 357348014753 Flavodoxin; Region: Flavodoxin_1; pfam00258 357348014754 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR_like2; cd06201 357348014755 FAD binding pocket [chemical binding]; other site 357348014756 FAD binding motif [chemical binding]; other site 357348014757 catalytic residues [active] 357348014758 NAD binding pocket [chemical binding]; other site 357348014759 phosphate binding motif [ion binding]; other site 357348014760 beta-alpha-beta structure motif; other site 357348014761 ApbE family; Region: ApbE; pfam02424 357348014762 ApbE family; Region: ApbE; pfam02424 357348014763 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 357348014764 aldehyde dehydrogenase family 7 member; Region: PLN02315 357348014765 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 357348014766 tetrameric interface [polypeptide binding]; other site 357348014767 NAD binding site [chemical binding]; other site 357348014768 catalytic residues [active] 357348014769 aminotransferase A; Validated; Region: PRK07683 357348014770 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 357348014771 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348014772 homodimer interface [polypeptide binding]; other site 357348014773 catalytic residue [active] 357348014774 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 357348014775 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 357348014776 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348014777 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 357348014778 dimerization interface [polypeptide binding]; other site 357348014779 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 357348014780 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 357348014781 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 357348014782 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 357348014783 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 357348014784 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 357348014785 putative active site [active] 357348014786 catalytic site [active] 357348014787 Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173 357348014788 putative active site [active] 357348014789 catalytic site [active] 357348014790 PLD-like domain; Region: PLDc_2; pfam13091 357348014791 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 357348014792 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 357348014793 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 357348014794 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348014795 D-galactonate transporter; Region: 2A0114; TIGR00893 357348014796 putative substrate translocation pore; other site 357348014797 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348014798 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 357348014799 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 357348014800 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 357348014801 Transcriptional regulators [Transcription]; Region: GntR; COG1802 357348014802 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 357348014803 DNA-binding site [nucleotide binding]; DNA binding site 357348014804 FCD domain; Region: FCD; pfam07729 357348014805 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 357348014806 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 357348014807 putative active site pocket [active] 357348014808 putative metal binding site [ion binding]; other site 357348014809 putative oxidoreductase; Provisional; Region: PRK10083 357348014810 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 357348014811 putative NAD(P) binding site [chemical binding]; other site 357348014812 catalytic Zn binding site [ion binding]; other site 357348014813 structural Zn binding site [ion binding]; other site 357348014814 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 357348014815 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 357348014816 homodimer interface [polypeptide binding]; other site 357348014817 NAD binding pocket [chemical binding]; other site 357348014818 ATP binding pocket [chemical binding]; other site 357348014819 Mg binding site [ion binding]; other site 357348014820 active-site loop [active] 357348014821 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 357348014822 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 357348014823 hypothetical protein; Provisional; Region: PRK02399 357348014824 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 357348014825 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 357348014826 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 357348014827 putative hydrophobic ligand binding site [chemical binding]; other site 357348014828 protein interface [polypeptide binding]; other site 357348014829 gate; other site 357348014830 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 357348014831 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 357348014832 Multicopper oxidase; Region: Cu-oxidase; pfam00394 357348014833 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 357348014834 Cytochrome c; Region: Cytochrom_C; pfam00034 357348014835 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 357348014836 Uncharacterized conserved protein [Function unknown]; Region: COG1262 357348014837 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 357348014838 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 357348014839 Cu(I) binding site [ion binding]; other site 357348014840 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 357348014841 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 357348014842 amidase catalytic site [active] 357348014843 Zn binding residues [ion binding]; other site 357348014844 substrate binding site [chemical binding]; other site 357348014845 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 357348014846 ADP-heptose:LPS heptosyl transferase I; Provisional; Region: PRK10964; cl15782 357348014847 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 357348014848 trimer interface [polypeptide binding]; other site 357348014849 Haemagglutinin; Region: HIM; pfam05662 357348014850 YadA-like C-terminal region; Region: YadA; pfam03895 357348014851 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 357348014852 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 357348014853 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 357348014854 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348014855 active site 357348014856 phosphorylation site [posttranslational modification] 357348014857 intermolecular recognition site; other site 357348014858 dimerization interface [polypeptide binding]; other site 357348014859 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357348014860 DNA binding site [nucleotide binding] 357348014861 MASE1; Region: MASE1; cl17823 357348014862 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357348014863 dimer interface [polypeptide binding]; other site 357348014864 phosphorylation site [posttranslational modification] 357348014865 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357348014866 ATP binding site [chemical binding]; other site 357348014867 G-X-G motif; other site 357348014868 Protein of unknown function (DUF770); Region: DUF770; pfam05591 357348014869 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 357348014870 Protein of unknown function (DUF877); Region: DUF877; pfam05943 357348014871 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 357348014872 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 357348014873 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 357348014874 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 357348014875 type VI secretion protein, VC_A0111 family; Region: VI_chp_1; TIGR03347 357348014876 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357348014877 Walker A motif; other site 357348014878 ATP binding site [chemical binding]; other site 357348014879 Walker B motif; other site 357348014880 arginine finger; other site 357348014881 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357348014882 Walker A motif; other site 357348014883 ATP binding site [chemical binding]; other site 357348014884 Walker B motif; other site 357348014885 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 357348014886 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 357348014887 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 357348014888 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 357348014889 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; cl02212 357348014890 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 357348014891 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 357348014892 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 357348014893 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 357348014894 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 357348014895 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 357348014896 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 357348014897 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 357348014898 Protein of unknown function (DUF3540); Region: DUF3540; pfam12059 357348014899 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 357348014900 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 357348014901 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 357348014902 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 357348014903 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 357348014904 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 357348014905 Bacterial Ig-like domain; Region: Big_5; pfam13205 357348014906 Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly...; Region: Peptidase_C19; cl02553 357348014907 active site 357348014908 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 357348014909 active site 357348014910 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357348014911 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357348014912 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 357348014913 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348014914 active site 357348014915 phosphorylation site [posttranslational modification] 357348014916 intermolecular recognition site; other site 357348014917 dimerization interface [polypeptide binding]; other site 357348014918 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 357348014919 DNA binding residues [nucleotide binding] 357348014920 dimerization interface [polypeptide binding]; other site 357348014921 chaperone protein SicP; Provisional; Region: PRK15329 357348014922 SicP binding; Region: SicP-binding; pfam09119 357348014923 type III secretion protein BopE; Provisional; Region: PRK15278 357348014924 SopE GEF domain; Region: SopE_GEF; pfam07487 357348014925 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 357348014926 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 357348014927 N-acetyl-D-glucosamine binding site [chemical binding]; other site 357348014928 catalytic residue [active] 357348014929 Phosphopantetheine attachment site; Region: PP-binding; cl09936 357348014930 type III effector protein IpaD/SipD/SspD; Region: SipD_IpaD_SspD; TIGR02553 357348014931 H-NS histone family; Region: Histone_HNS; pfam00816 357348014932 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 357348014933 Salmonella-Shigella invasin protein C (IpaC_SipC); Region: IpaC_SipC; pfam09599 357348014934 Secretion system effector C (SseC) like family; Region: SseC; pfam04888 357348014935 chaperone protein SicA; Provisional; Region: PRK15331 357348014936 Tetratricopeptide repeat; Region: TPR_3; pfam07720 357348014937 Tetratricopeptide repeat; Region: TPR_3; pfam07720 357348014938 type III secretion system protein SpaS; Validated; Region: PRK08156 357348014939 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 357348014940 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 357348014941 type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796 357348014942 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 357348014943 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 357348014944 ATP synthase SpaL; Validated; Region: PRK08149 357348014945 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 357348014946 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 357348014947 Walker A motif; other site 357348014948 ATP binding site [chemical binding]; other site 357348014949 Walker B motif; other site 357348014950 Invasion protein B family; Region: Invas_SpaK; cl04129 357348014951 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 357348014952 type III secretion system protein InvA; Provisional; Region: PRK15337 357348014953 type III secretion regulator YopN/LcrE/InvE/MxiC; Region: LcrE; TIGR02568 357348014954 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 357348014955 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 357348014956 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 357348014957 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 357348014958 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357348014959 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357348014960 type III secretion system protein PrgH/EprH; Region: PrgH; TIGR02554 357348014961 Type III secretion system protein PrgH-EprH (PrgH); Region: PrgH; pfam09480 357348014962 Type III secretion needle MxiH like; Region: MxiH; cl09641 357348014963 type III secretion system needle complex protein PrgJ; Provisional; Region: PRK15325 357348014964 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 357348014965 type III secretion apparatus protein OrgA/MxiK; Region: OrgA_MxiK; TIGR02555 357348014966 type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499 357348014967 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 357348014968 DNA binding site [nucleotide binding] 357348014969 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 357348014970 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 357348014971 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 357348014972 active site 357348014973 Zn binding site [ion binding]; other site 357348014974 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 357348014975 MarR family; Region: MarR_2; cl17246 357348014976 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 357348014977 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 357348014978 dimer interface [polypeptide binding]; other site 357348014979 putative metal binding site [ion binding]; other site 357348014980 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 357348014981 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348014982 putative substrate translocation pore; other site 357348014983 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357348014984 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348014985 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 357348014986 dimerization interface [polypeptide binding]; other site 357348014987 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 357348014988 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 357348014989 phosphate binding site [ion binding]; other site 357348014990 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 357348014991 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 357348014992 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 357348014993 peptidase domain interface [polypeptide binding]; other site 357348014994 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 357348014995 active site 357348014996 catalytic triad [active] 357348014997 calcium binding site [ion binding]; other site 357348014998 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 357348014999 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 357348015000 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 357348015001 putative DNA binding site [nucleotide binding]; other site 357348015002 putative Zn2+ binding site [ion binding]; other site 357348015003 AsnC family; Region: AsnC_trans_reg; pfam01037 357348015004 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 357348015005 putative hydrophobic ligand binding site [chemical binding]; other site 357348015006 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 357348015007 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 357348015008 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859 357348015009 acyl-CoA ligase (AMP-forming), exosortase A-associated; Region: ligase_PEP_1; TIGR03098 357348015010 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 357348015011 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_6; cd05922 357348015012 putative AMP binding site [chemical binding]; other site 357348015013 putative active site [active] 357348015014 acyl-activating enzyme (AAE) consensus motif; other site 357348015015 putative CoA binding site [chemical binding]; other site 357348015016 Autoinducer binding domain; Region: Autoind_bind; pfam03472 357348015017 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 357348015018 DNA binding residues [nucleotide binding] 357348015019 dimerization interface [polypeptide binding]; other site 357348015020 Autoinducer synthetase; Region: Autoind_synth; cl17404 357348015021 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 357348015022 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 357348015023 putative active site [active] 357348015024 putative FMN binding site [chemical binding]; other site 357348015025 putative substrate binding site [chemical binding]; other site 357348015026 putative catalytic residue [active] 357348015027 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 357348015028 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348015029 dimer interface [polypeptide binding]; other site 357348015030 conserved gate region; other site 357348015031 putative PBP binding loops; other site 357348015032 ABC-ATPase subunit interface; other site 357348015033 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 357348015034 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 357348015035 Walker A/P-loop; other site 357348015036 ATP binding site [chemical binding]; other site 357348015037 Q-loop/lid; other site 357348015038 ABC transporter signature motif; other site 357348015039 Walker B; other site 357348015040 D-loop; other site 357348015041 H-loop/switch region; other site 357348015042 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 357348015043 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 357348015044 substrate binding pocket [chemical binding]; other site 357348015045 membrane-bound complex binding site; other site 357348015046 hinge residues; other site 357348015047 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 357348015048 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 357348015049 active site 357348015050 iron coordination sites [ion binding]; other site 357348015051 substrate binding pocket [chemical binding]; other site 357348015052 cellulose synthase operon protein YhjU; Region: cellulose_yhjU; TIGR03368 357348015053 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 357348015054 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 357348015055 DXD motif; other site 357348015056 PilZ domain; Region: PilZ; pfam07238 357348015057 cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371 357348015058 cellulose biosynthesis protein BcsE; Region: cellulose_bcsE; TIGR03369 357348015059 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 357348015060 endo-1,4-D-glucanase; Provisional; Region: PRK11097 357348015061 cellulose synthase regulator protein; Provisional; Region: PRK11114 357348015062 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 357348015063 non-specific DNA binding site [nucleotide binding]; other site 357348015064 salt bridge; other site 357348015065 sequence-specific DNA binding site [nucleotide binding]; other site 357348015066 HipA N-terminal domain; Region: couple_hipA; TIGR03071 357348015067 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 357348015068 HipA-like N-terminal domain; Region: HipA_N; pfam07805 357348015069 HipA-like C-terminal domain; Region: HipA_C; pfam07804 357348015070 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357348015071 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348015072 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 357348015073 dimerization interface [polypeptide binding]; other site 357348015074 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 357348015075 agmatinase; Region: agmatinase; TIGR01230 357348015076 oligomer interface [polypeptide binding]; other site 357348015077 putative active site [active] 357348015078 Mn binding site [ion binding]; other site 357348015079 type II secretion system protein D; Region: type_II_gspD; TIGR02517 357348015080 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 357348015081 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 357348015082 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 357348015083 Bacterial shufflon protein, N-terminal constant region; Region: Shufflon_N; pfam04917 357348015084 PilM; Region: PilM; pfam07419 357348015085 PilS N terminal; Region: PilS; pfam08805 357348015086 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 357348015087 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 357348015088 Type II/IV secretion system protein; Region: T2SE; pfam00437 357348015089 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 357348015090 Walker A motif; other site 357348015091 ATP binding site [chemical binding]; other site 357348015092 Walker B motif; other site 357348015093 type IV pilus biogenesis protein PilP; Region: pilP_fam; TIGR03021 357348015094 type IVB pilus formation outer membrane protein, R64 PilN family; Region: pilus_B_mal_scr; TIGR02520 357348015095 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 357348015096 Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671 357348015097 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 357348015098 Walker A motif; other site 357348015099 ATP binding site [chemical binding]; other site 357348015100 Walker B motif; other site 357348015101 type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516 357348015102 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 357348015103 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348015104 active site 357348015105 phosphorylation site [posttranslational modification] 357348015106 intermolecular recognition site; other site 357348015107 dimerization interface [polypeptide binding]; other site 357348015108 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357348015109 DNA binding site [nucleotide binding] 357348015110 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357348015111 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357348015112 ATP binding site [chemical binding]; other site 357348015113 Mg2+ binding site [ion binding]; other site 357348015114 G-X-G motif; other site 357348015115 Bacterial type III secretion protein (HrpB1_HrpK); Region: HrpB1_HrpK; pfam09613 357348015116 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 357348015117 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357348015118 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357348015119 Tir chaperone protein (CesT) family; Region: CesT; cl08444 357348015120 Type III secretory pathway, component EscS [Intracellular trafficking and secretion]; Region: EscS; COG4794 357348015121 type III secretion system protein YscR; Provisional; Region: PRK12797 357348015122 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 357348015123 type III secretion protein HpaP; Region: HpaP; TIGR02557 357348015124 type III secretion protein, HrcV family; Region: hrcV; TIGR01399 357348015125 FHIPEP family; Region: FHIPEP; pfam00771 357348015126 type III secretion system protein HrcU; Validated; Region: PRK09108 357348015127 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 357348015128 type III secretion protein HrpB1/HrpK; Region: HrpB1_HrpK; TIGR02561 357348015129 type III secretion protein HrpB2; Region: HrpB2; TIGR02558 357348015130 type III secretion apparatus lipoprotein, YscJ/HrcJ family; Region: III_secr_YscJ; TIGR02544 357348015131 type III secretion protein HrpB4; Region: HrpB4; TIGR02560 357348015132 Bacterial type III secretion protein (HrpB4); Region: HrpB4; pfam09502 357348015133 type III secretion system protein HrpB; Validated; Region: PRK09098 357348015134 Flagellar assembly protein FliH; Region: FliH; pfam02108 357348015135 type III secretion system ATPase; Provisional; Region: PRK09099 357348015136 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 357348015137 Walker A motif; other site 357348015138 ATP binding site [chemical binding]; other site 357348015139 Walker B motif; other site 357348015140 type III secretion protein HrpB7; Region: HrpB7; TIGR02559 357348015141 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 357348015142 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 357348015143 substrate binding pocket [chemical binding]; other site 357348015144 active site 357348015145 iron coordination sites [ion binding]; other site 357348015146 Condensation domain; Region: Condensation; pfam00668 357348015147 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 357348015148 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 357348015149 acyl-activating enzyme (AAE) consensus motif; other site 357348015150 AMP binding site [chemical binding]; other site 357348015151 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 357348015152 Condensation domain; Region: Condensation; pfam00668 357348015153 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 357348015154 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 357348015155 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 357348015156 acyl-activating enzyme (AAE) consensus motif; other site 357348015157 AMP binding site [chemical binding]; other site 357348015158 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 357348015159 Condensation domain; Region: Condensation; pfam00668 357348015160 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 357348015161 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 357348015162 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 357348015163 acyl-activating enzyme (AAE) consensus motif; other site 357348015164 AMP binding site [chemical binding]; other site 357348015165 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 357348015166 Condensation domain; Region: Condensation; pfam00668 357348015167 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 357348015168 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 357348015169 acyl-activating enzyme (AAE) consensus motif; other site 357348015170 AMP binding site [chemical binding]; other site 357348015171 active site 357348015172 CoA binding site [chemical binding]; other site 357348015173 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 357348015174 Condensation domain; Region: Condensation; pfam00668 357348015175 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 357348015176 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 357348015177 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 357348015178 acyl-activating enzyme (AAE) consensus motif; other site 357348015179 AMP binding site [chemical binding]; other site 357348015180 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 357348015181 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 357348015182 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 357348015183 Condensation domain; Region: Condensation; pfam00668 357348015184 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 357348015185 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 357348015186 acyl-activating enzyme (AAE) consensus motif; other site 357348015187 AMP binding site [chemical binding]; other site 357348015188 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 357348015189 Condensation domain; Region: Condensation; pfam00668 357348015190 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 357348015191 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 357348015192 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 357348015193 acyl-activating enzyme (AAE) consensus motif; other site 357348015194 AMP binding site [chemical binding]; other site 357348015195 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 357348015196 Condensation domain; Region: Condensation; pfam00668 357348015197 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 357348015198 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 357348015199 acyl-activating enzyme (AAE) consensus motif; other site 357348015200 AMP binding site [chemical binding]; other site 357348015201 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 357348015202 Condensation domain; Region: Condensation; pfam00668 357348015203 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 357348015204 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 357348015205 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 357348015206 acyl-activating enzyme (AAE) consensus motif; other site 357348015207 AMP binding site [chemical binding]; other site 357348015208 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 357348015209 Condensation domain; Region: Condensation; pfam00668 357348015210 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 357348015211 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 357348015212 acyl-activating enzyme (AAE) consensus motif; other site 357348015213 AMP binding site [chemical binding]; other site 357348015214 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 357348015215 Condensation domain; Region: Condensation; pfam00668 357348015216 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 357348015217 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 357348015218 acyl-activating enzyme (AAE) consensus motif; other site 357348015219 AMP binding site [chemical binding]; other site 357348015220 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 357348015221 Condensation domain; Region: Condensation; pfam00668 357348015222 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 357348015223 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 357348015224 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 357348015225 acyl-activating enzyme (AAE) consensus motif; other site 357348015226 AMP binding site [chemical binding]; other site 357348015227 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 357348015228 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 357348015229 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 357348015230 inhibitor-cofactor binding pocket; inhibition site 357348015231 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348015232 catalytic residue [active] 357348015233 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348015234 putative substrate translocation pore; other site 357348015235 pyruvate dehydrogenase; Provisional; Region: PRK09124 357348015236 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 357348015237 PYR/PP interface [polypeptide binding]; other site 357348015238 tetramer interface [polypeptide binding]; other site 357348015239 dimer interface [polypeptide binding]; other site 357348015240 TPP binding site [chemical binding]; other site 357348015241 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 357348015242 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 357348015243 TPP-binding site [chemical binding]; other site 357348015244 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 357348015245 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 357348015246 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 357348015247 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 357348015248 putative active site [active] 357348015249 putative catalytic site [active] 357348015250 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 357348015251 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357348015252 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348015253 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 357348015254 putative dimerization interface [polypeptide binding]; other site 357348015255 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357348015256 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348015257 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 357348015258 putative effector binding pocket; other site 357348015259 dimerization interface [polypeptide binding]; other site 357348015260 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348015261 putative substrate translocation pore; other site 357348015262 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 357348015263 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357348015264 ATP binding site [chemical binding]; other site 357348015265 Mg2+ binding site [ion binding]; other site 357348015266 G-X-G motif; other site 357348015267 Uncharacterized conserved protein [Function unknown]; Region: COG3287 357348015268 FIST N domain; Region: FIST; pfam08495 357348015269 FIST C domain; Region: FIST_C; pfam10442 357348015270 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 357348015271 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348015272 active site 357348015273 phosphorylation site [posttranslational modification] 357348015274 intermolecular recognition site; other site 357348015275 dimerization interface [polypeptide binding]; other site 357348015276 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 357348015277 Zn2+ binding site [ion binding]; other site 357348015278 Mg2+ binding site [ion binding]; other site 357348015279 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820 357348015280 Ricin-type beta-trefoil; Region: RICIN; smart00458 357348015281 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 357348015282 putative sugar binding sites [chemical binding]; other site 357348015283 Q-X-W motif; other site 357348015284 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 357348015285 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 357348015286 putative sugar binding sites [chemical binding]; other site 357348015287 Q-X-W motif; other site 357348015288 Kelch motif; Region: Kelch_6; pfam13964 357348015289 C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851 357348015290 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 357348015291 Cu(I) binding site [ion binding]; other site 357348015292 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 357348015293 active site 357348015294 nucleophile elbow; other site 357348015295 benzoate transport; Region: 2A0115; TIGR00895 357348015296 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 357348015297 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 357348015298 Cytochrome P450; Region: p450; cl12078 357348015299 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 357348015300 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 357348015301 FMN-binding pocket [chemical binding]; other site 357348015302 flavin binding motif; other site 357348015303 phosphate binding motif [ion binding]; other site 357348015304 beta-alpha-beta structure motif; other site 357348015305 NAD binding pocket [chemical binding]; other site 357348015306 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 357348015307 catalytic loop [active] 357348015308 iron binding site [ion binding]; other site 357348015309 H+ Antiporter protein; Region: 2A0121; TIGR00900 357348015310 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348015311 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 357348015312 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 357348015313 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 357348015314 Amidase; Region: Amidase; cl11426 357348015315 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 357348015316 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 357348015317 G1 box; other site 357348015318 putative GEF interaction site [polypeptide binding]; other site 357348015319 GTP/Mg2+ binding site [chemical binding]; other site 357348015320 Switch I region; other site 357348015321 G2 box; other site 357348015322 G3 box; other site 357348015323 Switch II region; other site 357348015324 G4 box; other site 357348015325 G5 box; other site 357348015326 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 357348015327 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 357348015328 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 357348015329 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 357348015330 selenocysteine synthase; Provisional; Region: PRK04311 357348015331 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 357348015332 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 357348015333 catalytic residue [active] 357348015334 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 357348015335 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 357348015336 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 357348015337 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 357348015338 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 357348015339 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 357348015340 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 357348015341 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 357348015342 [4Fe-4S] binding site [ion binding]; other site 357348015343 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 357348015344 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 357348015345 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 357348015346 molybdopterin cofactor binding site; other site 357348015347 Uncharacterized conserved protein [Function unknown]; Region: COG1434 357348015348 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 357348015349 putative active site [active] 357348015350 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 357348015351 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 357348015352 substrate binding pocket [chemical binding]; other site 357348015353 membrane-bound complex binding site; other site 357348015354 hinge residues; other site 357348015355 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348015356 dimer interface [polypeptide binding]; other site 357348015357 conserved gate region; other site 357348015358 putative PBP binding loops; other site 357348015359 ABC-ATPase subunit interface; other site 357348015360 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 357348015361 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 357348015362 Walker A/P-loop; other site 357348015363 ATP binding site [chemical binding]; other site 357348015364 Q-loop/lid; other site 357348015365 ABC transporter signature motif; other site 357348015366 Walker B; other site 357348015367 D-loop; other site 357348015368 H-loop/switch region; other site 357348015369 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 357348015370 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 357348015371 active site 357348015372 non-prolyl cis peptide bond; other site 357348015373 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 357348015374 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 357348015375 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 357348015376 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 357348015377 substrate binding pocket [chemical binding]; other site 357348015378 membrane-bound complex binding site; other site 357348015379 hinge residues; other site 357348015380 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 357348015381 ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994 357348015382 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_2; cd06252 357348015383 putative active site [active] 357348015384 Zn binding site [ion binding]; other site 357348015385 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 357348015386 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 357348015387 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 357348015388 trimer interface [polypeptide binding]; other site 357348015389 eyelet of channel; other site 357348015390 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 357348015391 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 357348015392 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 357348015393 active site 357348015394 tetramer interface; other site 357348015395 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 357348015396 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357348015397 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 357348015398 putative ADP-binding pocket [chemical binding]; other site 357348015399 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 357348015400 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357348015401 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 357348015402 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 357348015403 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 357348015404 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 357348015405 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 357348015406 NADP-binding site; other site 357348015407 homotetramer interface [polypeptide binding]; other site 357348015408 substrate binding site [chemical binding]; other site 357348015409 homodimer interface [polypeptide binding]; other site 357348015410 active site 357348015411 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 357348015412 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357348015413 NAD(P) binding site [chemical binding]; other site 357348015414 active site 357348015415 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 357348015416 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 357348015417 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 357348015418 homodimer interface [polypeptide binding]; other site 357348015419 substrate-cofactor binding pocket; other site 357348015420 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348015421 catalytic residue [active] 357348015422 amidophosphoribosyltransferase; Provisional; Region: PRK09246 357348015423 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 357348015424 active site 357348015425 tetramer interface [polypeptide binding]; other site 357348015426 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 357348015427 active site 357348015428 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 357348015429 Colicin V production protein; Region: Colicin_V; pfam02674 357348015430 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147 357348015431 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 357348015432 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 357348015433 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 357348015434 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 357348015435 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 357348015436 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 357348015437 substrate binding site [chemical binding]; other site 357348015438 active site 357348015439 catalytic residues [active] 357348015440 heterodimer interface [polypeptide binding]; other site 357348015441 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 357348015442 DNA methylase; Region: N6_N4_Mtase; pfam01555 357348015443 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 357348015444 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 357348015445 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348015446 catalytic residue [active] 357348015447 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 357348015448 active site 357348015449 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 357348015450 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 357348015451 dimerization interface 3.5A [polypeptide binding]; other site 357348015452 active site 357348015453 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 357348015454 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 357348015455 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 357348015456 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 357348015457 tartrate dehydrogenase; Region: TTC; TIGR02089 357348015458 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 357348015459 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 357348015460 substrate binding site [chemical binding]; other site 357348015461 Predicted small secreted protein [Function unknown]; Region: COG5510 357348015462 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 357348015463 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 357348015464 substrate binding site [chemical binding]; other site 357348015465 ligand binding site [chemical binding]; other site 357348015466 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 357348015467 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 357348015468 active site 357348015469 non-prolyl cis peptide bond; other site 357348015470 cyclase homology domain; Region: CHD; cd07302 357348015471 nucleotidyl binding site; other site 357348015472 metal binding site [ion binding]; metal-binding site 357348015473 dimer interface [polypeptide binding]; other site 357348015474 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 357348015475 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 357348015476 putative DNA binding site [nucleotide binding]; other site 357348015477 putative Zn2+ binding site [ion binding]; other site 357348015478 AsnC family; Region: AsnC_trans_reg; pfam01037 357348015479 2-oxoacid dehydrogenase subunit E1; Provisional; Region: PRK13012 357348015480 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 357348015481 dimer interface [polypeptide binding]; other site 357348015482 TPP-binding site [chemical binding]; other site 357348015483 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 357348015484 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 357348015485 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 357348015486 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 357348015487 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 357348015488 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357348015489 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 357348015490 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 357348015491 dimer interface [polypeptide binding]; other site 357348015492 active site 357348015493 citrylCoA binding site [chemical binding]; other site 357348015494 NADH binding [chemical binding]; other site 357348015495 cationic pore residues; other site 357348015496 oxalacetate/citrate binding site [chemical binding]; other site 357348015497 coenzyme A binding site [chemical binding]; other site 357348015498 catalytic triad [active] 357348015499 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 357348015500 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 357348015501 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057 357348015502 L-aspartate oxidase; Provisional; Region: PRK06175 357348015503 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 357348015504 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 357348015505 SdhC subunit interface [polypeptide binding]; other site 357348015506 proximal heme binding site [chemical binding]; other site 357348015507 cardiolipin binding site; other site 357348015508 Iron-sulfur protein interface; other site 357348015509 proximal quinone binding site [chemical binding]; other site 357348015510 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 357348015511 Iron-sulfur protein interface; other site 357348015512 proximal quinone binding site [chemical binding]; other site 357348015513 SdhD (CybS) interface [polypeptide binding]; other site 357348015514 proximal heme binding site [chemical binding]; other site 357348015515 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 357348015516 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 357348015517 DNA-binding site [nucleotide binding]; DNA binding site 357348015518 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 357348015519 malate dehydrogenase; Provisional; Region: PRK05442 357348015520 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 357348015521 NAD(P) binding site [chemical binding]; other site 357348015522 dimer interface [polypeptide binding]; other site 357348015523 malate binding site [chemical binding]; other site 357348015524 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 357348015525 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 357348015526 2-methylcitrate dehydratase; Region: prpD; TIGR02330 357348015527 aconitate hydratase; Provisional; Region: acnA; PRK12881 357348015528 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 357348015529 substrate binding site [chemical binding]; other site 357348015530 ligand binding site [chemical binding]; other site 357348015531 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 357348015532 substrate binding site [chemical binding]; other site 357348015533 haemagglutination activity domain; Region: Haemagg_act; pfam05860 357348015534 Inositol polyphosphate kinase; Region: IPK; cl12283 357348015535 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 357348015536 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 357348015537 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 357348015538 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 357348015539 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 357348015540 Cytochrome c [Energy production and conversion]; Region: COG3258 357348015541 Cytochrome c; Region: Cytochrom_C; pfam00034 357348015542 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 357348015543 Common central domain of tyrosinase; Region: Tyrosinase; pfam00264 357348015544 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 357348015545 peptidase domain interface [polypeptide binding]; other site 357348015546 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 357348015547 active site 357348015548 catalytic triad [active] 357348015549 calcium binding site [ion binding]; other site 357348015550 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 357348015551 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348015552 putative PBP binding loops; other site 357348015553 dimer interface [polypeptide binding]; other site 357348015554 ABC-ATPase subunit interface; other site 357348015555 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348015556 dimer interface [polypeptide binding]; other site 357348015557 conserved gate region; other site 357348015558 putative PBP binding loops; other site 357348015559 ABC-ATPase subunit interface; other site 357348015560 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 357348015561 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 357348015562 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 357348015563 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357348015564 Walker A/P-loop; other site 357348015565 ATP binding site [chemical binding]; other site 357348015566 Q-loop/lid; other site 357348015567 ABC transporter signature motif; other site 357348015568 Walker B; other site 357348015569 D-loop; other site 357348015570 H-loop/switch region; other site 357348015571 TOBE domain; Region: TOBE_2; pfam08402 357348015572 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 357348015573 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 357348015574 DNA-binding site [nucleotide binding]; DNA binding site 357348015575 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 357348015576 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348015577 homodimer interface [polypeptide binding]; other site 357348015578 catalytic residue [active] 357348015579 lipase chaperone; Provisional; Region: PRK01294 357348015580 Proteobacterial lipase chaperone protein; Region: Lipase_chap; cl02224 357348015581 Lipase (class 2); Region: Lipase_2; pfam01674 357348015582 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 357348015583 PGAP1-like protein; Region: PGAP1; pfam07819 357348015584 TonB-dependent copper receptor; Region: TonB-copper; TIGR01778 357348015585 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 357348015586 N-terminal plug; other site 357348015587 ligand-binding site [chemical binding]; other site 357348015588 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 357348015589 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 357348015590 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 357348015591 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 357348015592 E3 interaction surface; other site 357348015593 lipoyl attachment site [posttranslational modification]; other site 357348015594 Cupin domain; Region: Cupin_2; cl17218 357348015595 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 357348015596 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 357348015597 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 357348015598 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 357348015599 Protein of unknown function (DUF938); Region: DUF938; pfam06080 357348015600 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 357348015601 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 357348015602 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 357348015603 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 357348015604 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357348015605 S-adenosylmethionine binding site [chemical binding]; other site 357348015606 Methyltransferase domain; Region: Methyltransf_31; pfam13847 357348015607 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 357348015608 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 357348015609 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 357348015610 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 357348015611 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 357348015612 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 357348015613 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 357348015614 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 357348015615 DNA binding residues [nucleotide binding] 357348015616 DNA primase; Validated; Region: dnaG; PRK05667 357348015617 CHC2 zinc finger; Region: zf-CHC2; pfam01807 357348015618 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 357348015619 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 357348015620 active site 357348015621 metal binding site [ion binding]; metal-binding site 357348015622 interdomain interaction site; other site 357348015623 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 357348015624 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 357348015625 Yqey-like protein; Region: YqeY; pfam09424 357348015626 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 357348015627 Predicted flavoproteins [General function prediction only]; Region: COG2081 357348015628 UGMP family protein; Validated; Region: PRK09604 357348015629 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 357348015630 putative GTP cyclohydrolase; Provisional; Region: PRK13674 357348015631 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 357348015632 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 357348015633 TPP-binding site; other site 357348015634 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 357348015635 PYR/PP interface [polypeptide binding]; other site 357348015636 dimer interface [polypeptide binding]; other site 357348015637 TPP binding site [chemical binding]; other site 357348015638 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 357348015639 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 357348015640 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 357348015641 substrate binding pocket [chemical binding]; other site 357348015642 chain length determination region; other site 357348015643 substrate-Mg2+ binding site; other site 357348015644 catalytic residues [active] 357348015645 aspartate-rich region 1; other site 357348015646 active site lid residues [active] 357348015647 aspartate-rich region 2; other site 357348015648 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 357348015649 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 357348015650 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 357348015651 [2Fe-2S] cluster binding site [ion binding]; other site 357348015652 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 357348015653 alpha subunit interface [polypeptide binding]; other site 357348015654 active site 357348015655 substrate binding site [chemical binding]; other site 357348015656 Fe binding site [ion binding]; other site 357348015657 Transposase domain (DUF772); Region: DUF772; pfam05598 357348015658 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 357348015659 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 357348015660 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 357348015661 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 357348015662 active site residue [active] 357348015663 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 357348015664 active site residue [active] 357348015665 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 357348015666 Predicted membrane protein [Function unknown]; Region: COG4655 357348015667 Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977 357348015668 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 357348015669 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 357348015670 DNA polymerase I; Provisional; Region: PRK05755 357348015671 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 357348015672 active site 357348015673 metal binding site 1 [ion binding]; metal-binding site 357348015674 putative 5' ssDNA interaction site; other site 357348015675 metal binding site 3; metal-binding site 357348015676 metal binding site 2 [ion binding]; metal-binding site 357348015677 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 357348015678 putative DNA binding site [nucleotide binding]; other site 357348015679 putative metal binding site [ion binding]; other site 357348015680 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 357348015681 active site 357348015682 catalytic site [active] 357348015683 substrate binding site [chemical binding]; other site 357348015684 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 357348015685 active site 357348015686 DNA binding site [nucleotide binding] 357348015687 catalytic site [active] 357348015688 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 357348015689 Uncharacterized conserved protein [Function unknown]; Region: COG1683 357348015690 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 357348015691 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 357348015692 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 357348015693 active site 357348015694 Int/Topo IB signature motif; other site 357348015695 DNA binding site [nucleotide binding] 357348015696 AMP nucleosidase; Provisional; Region: PRK08292 357348015697 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 357348015698 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 357348015699 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 357348015700 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 357348015701 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 357348015702 putative active site [active] 357348015703 putative substrate binding site [chemical binding]; other site 357348015704 ATP binding site [chemical binding]; other site 357348015705 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 357348015706 MarR family; Region: MarR; pfam01047 357348015707 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 357348015708 Protein of unknown function (DUF3563); Region: DUF3563; pfam12086 357348015709 Esterase PHB depolymerase; Region: Esterase_phd; pfam10503 357348015710 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 357348015711 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 357348015712 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348015713 putative PBP binding loops; other site 357348015714 dimer interface [polypeptide binding]; other site 357348015715 ABC-ATPase subunit interface; other site 357348015716 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357348015717 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 357348015718 Walker A/P-loop; other site 357348015719 ATP binding site [chemical binding]; other site 357348015720 Q-loop/lid; other site 357348015721 ABC transporter signature motif; other site 357348015722 Walker B; other site 357348015723 D-loop; other site 357348015724 H-loop/switch region; other site 357348015725 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 357348015726 molybdenum-pterin binding domain; Region: Mop; TIGR00638 357348015727 TOBE domain; Region: TOBE; cl01440 357348015728 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 357348015729 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 357348015730 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 357348015731 dimer interface [polypeptide binding]; other site 357348015732 hexamer interface [polypeptide binding]; other site 357348015733 active site 2 [active] 357348015734 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348015735 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 357348015736 dimerization interface [polypeptide binding]; other site 357348015737 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 357348015738 EamA-like transporter family; Region: EamA; pfam00892 357348015739 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357348015740 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357348015741 dimer interface [polypeptide binding]; other site 357348015742 phosphorylation site [posttranslational modification] 357348015743 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 357348015744 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 357348015745 Domain of unknown function DUF21; Region: DUF21; pfam01595 357348015746 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 357348015747 Transporter associated domain; Region: CorC_HlyC; smart01091 357348015748 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 357348015749 thiamine phosphate binding site [chemical binding]; other site 357348015750 active site 357348015751 pyrophosphate binding site [ion binding]; other site 357348015752 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 357348015753 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 357348015754 active site 357348015755 catalytic site [active] 357348015756 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 357348015757 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357348015758 S-adenosylmethionine binding site [chemical binding]; other site 357348015759 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 357348015760 putative deacylase active site [active] 357348015761 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 357348015762 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 357348015763 phosphate binding site [ion binding]; other site 357348015764 Homeodomain-like domain; Region: HTH_23; pfam13384 357348015765 Winged helix-turn helix; Region: HTH_29; pfam13551 357348015766 Winged helix-turn helix; Region: HTH_33; pfam13592 357348015767 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 357348015768 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 357348015769 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357348015770 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357348015771 Autoinducer binding domain; Region: Autoind_bind; pfam03472 357348015772 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 357348015773 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 357348015774 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 357348015775 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 357348015776 active site 357348015777 catalytic residues [active] 357348015778 metal binding site [ion binding]; metal-binding site 357348015779 DmpG-like communication domain; Region: DmpG_comm; pfam07836 357348015780 acetaldehyde dehydrogenase (acetylating); Region: ac_ald_DH_ac; TIGR03215 357348015781 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 357348015782 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 357348015783 Thioesterase domain; Region: Thioesterase; pfam00975 357348015784 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 357348015785 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 357348015786 homodimer interface [polypeptide binding]; other site 357348015787 substrate-cofactor binding pocket; other site 357348015788 catalytic residue [active] 357348015789 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 357348015790 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 357348015791 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 357348015792 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 357348015793 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 357348015794 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 357348015795 acyl-activating enzyme (AAE) consensus motif; other site 357348015796 AMP binding site [chemical binding]; other site 357348015797 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 357348015798 dimerization interface [polypeptide binding]; other site 357348015799 putative DNA binding site [nucleotide binding]; other site 357348015800 putative Zn2+ binding site [ion binding]; other site 357348015801 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_5; cd08898 357348015802 putative hydrophobic ligand binding site [chemical binding]; other site 357348015803 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 357348015804 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 357348015805 active site 357348015806 metal binding site [ion binding]; metal-binding site 357348015807 RES domain; Region: RES; smart00953 357348015808 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 357348015809 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 357348015810 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 357348015811 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 357348015812 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 357348015813 Cupin domain; Region: Cupin_2; cl17218 357348015814 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357348015815 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357348015816 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357348015817 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 357348015818 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357348015819 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 357348015820 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 357348015821 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 357348015822 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357348015823 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 357348015824 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 357348015825 active site 357348015826 tyrosine kinase; Provisional; Region: PRK11519 357348015827 Chain length determinant protein; Region: Wzz; cl15801 357348015828 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 357348015829 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 357348015830 polysaccharide export protein Wza; Provisional; Region: PRK15078 357348015831 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 357348015832 SLBB domain; Region: SLBB; pfam10531 357348015833 SLBB domain; Region: SLBB; pfam10531 357348015834 Low molecular weight phosphatase family; Region: LMWPc; cl00105 357348015835 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 357348015836 active site 357348015837 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 357348015838 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 357348015839 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 357348015840 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 357348015841 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 357348015842 Bacterial sugar transferase; Region: Bac_transf; pfam02397 357348015843 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 357348015844 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 357348015845 Substrate binding site; other site 357348015846 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 357348015847 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 357348015848 Protein of unknown function (DUF3501); Region: DUF3501; pfam12007 357348015849 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 357348015850 Cysteine-rich domain; Region: CCG; pfam02754 357348015851 Cysteine-rich domain; Region: CCG; pfam02754 357348015852 Rubrerythrin [Energy production and conversion]; Region: COG1592 357348015853 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 357348015854 binuclear metal center [ion binding]; other site 357348015855 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 357348015856 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 357348015857 amidase catalytic site [active] 357348015858 Zn binding residues [ion binding]; other site 357348015859 substrate binding site [chemical binding]; other site 357348015860 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 357348015861 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 357348015862 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 357348015863 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 357348015864 putative hydrophobic ligand binding site [chemical binding]; other site 357348015865 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 357348015866 YCII-related domain; Region: YCII; cl00999 357348015867 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 357348015868 generic binding surface I; other site 357348015869 generic binding surface II; other site 357348015870 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 357348015871 putative active site [active] 357348015872 putative catalytic site [active] 357348015873 putative Mg binding site IVb [ion binding]; other site 357348015874 putative phosphate binding site [ion binding]; other site 357348015875 putative DNA binding site [nucleotide binding]; other site 357348015876 putative Mg binding site IVa [ion binding]; other site 357348015877 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 357348015878 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 357348015879 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 357348015880 Domain of unknown function DUF20; Region: UPF0118; pfam01594 357348015881 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 357348015882 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 357348015883 N-terminal plug; other site 357348015884 ligand-binding site [chemical binding]; other site 357348015885 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348015886 putative substrate translocation pore; other site 357348015887 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 357348015888 Prostaglandin dehydrogenases; Region: PGDH; cd05288 357348015889 NAD(P) binding site [chemical binding]; other site 357348015890 substrate binding site [chemical binding]; other site 357348015891 dimer interface [polypeptide binding]; other site 357348015892 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357348015893 short chain dehydrogenase; Validated; Region: PRK07069 357348015894 NAD(P) binding site [chemical binding]; other site 357348015895 active site 357348015896 short chain dehydrogenase; Provisional; Region: PRK07035 357348015897 classical (c) SDRs; Region: SDR_c; cd05233 357348015898 NAD(P) binding site [chemical binding]; other site 357348015899 active site 357348015900 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 357348015901 catalytic core [active] 357348015902 Phosphotransferase enzyme family; Region: APH; pfam01636 357348015903 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 357348015904 putative active site [active] 357348015905 putative substrate binding site [chemical binding]; other site 357348015906 ATP binding site [chemical binding]; other site 357348015907 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 357348015908 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 357348015909 active site 357348015910 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357348015911 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348015912 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 357348015913 substrate binding pocket [chemical binding]; other site 357348015914 dimerization interface [polypeptide binding]; other site 357348015915 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 357348015916 Domain of unknown function (DUF3472); Region: DUF3472; pfam11958 357348015917 Dyp-type peroxidase family; Region: Dyp_perox_fam; TIGR01413 357348015918 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 357348015919 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 357348015920 Walker A/P-loop; other site 357348015921 ATP binding site [chemical binding]; other site 357348015922 Q-loop/lid; other site 357348015923 ABC transporter signature motif; other site 357348015924 Walker B; other site 357348015925 D-loop; other site 357348015926 H-loop/switch region; other site 357348015927 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 357348015928 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 357348015929 conserved cys residue [active] 357348015930 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 357348015931 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 357348015932 conserved cys residue [active] 357348015933 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357348015934 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 357348015935 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 357348015936 active site 357348015937 HIGH motif; other site 357348015938 dimer interface [polypeptide binding]; other site 357348015939 KMSKS motif; other site 357348015940 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 357348015941 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 357348015942 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357348015943 CAAX protease self-immunity; Region: Abi; pfam02517 357348015944 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 357348015945 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 357348015946 Cl- selectivity filter; other site 357348015947 Cl- binding residues [ion binding]; other site 357348015948 pore gating glutamate residue; other site 357348015949 dimer interface [polypeptide binding]; other site 357348015950 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 357348015951 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 357348015952 motif II; other site 357348015953 chemotaxis-specific methylesterase; Provisional; Region: PRK12555 357348015954 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348015955 active site 357348015956 phosphorylation site [posttranslational modification] 357348015957 intermolecular recognition site; other site 357348015958 CheB methylesterase; Region: CheB_methylest; pfam01339 357348015959 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 357348015960 putative binding surface; other site 357348015961 active site 357348015962 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 357348015963 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357348015964 ATP binding site [chemical binding]; other site 357348015965 Mg2+ binding site [ion binding]; other site 357348015966 G-X-G motif; other site 357348015967 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 357348015968 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348015969 Response regulator receiver domain; Region: Response_reg; pfam00072 357348015970 active site 357348015971 phosphorylation site [posttranslational modification] 357348015972 intermolecular recognition site; other site 357348015973 dimerization interface [polypeptide binding]; other site 357348015974 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 357348015975 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 357348015976 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357348015977 S-adenosylmethionine binding site [chemical binding]; other site 357348015978 TPR repeat; Region: TPR_11; pfam13414 357348015979 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 357348015980 binding surface 357348015981 TPR motif; other site 357348015982 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 357348015983 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 357348015984 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 357348015985 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 357348015986 dimerization interface [polypeptide binding]; other site 357348015987 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 357348015988 dimer interface [polypeptide binding]; other site 357348015989 putative CheW interface [polypeptide binding]; other site 357348015990 Response regulator receiver domain; Region: Response_reg; pfam00072 357348015991 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348015992 active site 357348015993 phosphorylation site [posttranslational modification] 357348015994 intermolecular recognition site; other site 357348015995 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357348015996 dimerization interface [polypeptide binding]; other site 357348015997 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357348015998 dimer interface [polypeptide binding]; other site 357348015999 phosphorylation site [posttranslational modification] 357348016000 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357348016001 ATP binding site [chemical binding]; other site 357348016002 Mg2+ binding site [ion binding]; other site 357348016003 G-X-G motif; other site 357348016004 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 357348016005 active site 357348016006 catalytic site [active] 357348016007 Aldehyde dehydrogenase family 21A1-like; Region: ALDH_F21_RNP123; cd07147 357348016008 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 357348016009 NAD(P) binding site [chemical binding]; other site 357348016010 catalytic residues [active] 357348016011 acetolactate synthase; Reviewed; Region: PRK08322 357348016012 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 357348016013 PYR/PP interface [polypeptide binding]; other site 357348016014 dimer interface [polypeptide binding]; other site 357348016015 TPP binding site [chemical binding]; other site 357348016016 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 357348016017 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 357348016018 TPP-binding site [chemical binding]; other site 357348016019 dimer interface [polypeptide binding]; other site 357348016020 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 357348016021 Protein of unknown function (DUF445); Region: DUF445; pfam04286 357348016022 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 357348016023 PLD-like domain; Region: PLDc_2; pfam13091 357348016024 putative active site [active] 357348016025 catalytic site [active] 357348016026 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 357348016027 PLD-like domain; Region: PLDc_2; pfam13091 357348016028 putative active site [active] 357348016029 catalytic site [active] 357348016030 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 357348016031 HIT family signature motif; other site 357348016032 catalytic residue [active] 357348016033 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 357348016034 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 357348016035 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 357348016036 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 357348016037 [2Fe-2S] cluster binding site [ion binding]; other site 357348016038 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 357348016039 inter-subunit interface; other site 357348016040 Rieske non-heme iron oxygenase (RO) family, Ortho-halobenzoate-1,2-dioxygenase (OHBDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of OHBDO, salicylate 5-hydroxylase (S5H); Region: Rieske_RO_Alpha_OHBDO_like; cd03545 357348016041 C-terminal catalytic domain of the large/alpha subunit (ahdA1c) of a ring-hydroxylating dioxygenase from Sphingomonas sp. strain P2 and related proteins; Region: RHO_alpha_C_ahdA1c-like; cd08880 357348016042 putative alpha subunit interface [polypeptide binding]; other site 357348016043 putative active site [active] 357348016044 putative substrate binding site [chemical binding]; other site 357348016045 Fe binding site [ion binding]; other site 357348016046 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357348016047 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 357348016048 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348016049 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 357348016050 dimerization interface [polypeptide binding]; other site 357348016051 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 357348016052 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 357348016053 octamer interface [polypeptide binding]; other site 357348016054 active site 357348016055 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 357348016056 Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460 357348016057 dimer interface [polypeptide binding]; other site 357348016058 active site 357348016059 muconolactone delta-isomerase; Region: muco_delta; TIGR03221 357348016060 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 357348016061 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 357348016062 Subunit I/III interface [polypeptide binding]; other site 357348016063 Subunit III/IV interface [polypeptide binding]; other site 357348016064 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 357348016065 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 357348016066 D-pathway; other site 357348016067 Putative ubiquinol binding site [chemical binding]; other site 357348016068 Low-spin heme (heme b) binding site [chemical binding]; other site 357348016069 Putative water exit pathway; other site 357348016070 Binuclear center (heme o3/CuB) [ion binding]; other site 357348016071 K-pathway; other site 357348016072 Putative proton exit pathway; other site 357348016073 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 357348016074 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 357348016075 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 357348016076 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 357348016077 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 357348016078 active site 357348016079 FMN binding site [chemical binding]; other site 357348016080 2,4-decadienoyl-CoA binding site; other site 357348016081 catalytic residue [active] 357348016082 4Fe-4S cluster binding site [ion binding]; other site 357348016083 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 357348016084 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 357348016085 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 357348016086 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 357348016087 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 357348016088 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357348016089 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348016090 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 357348016091 dimerization interface [polypeptide binding]; other site 357348016092 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357348016093 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 357348016094 NAD(P) binding site [chemical binding]; other site 357348016095 active site 357348016096 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 357348016097 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348016098 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in benzoate catabolism; contains the type 2 periplasmic binding fold; Region: PBP2_BenM_CatM_CatR; cd08445 357348016099 dimerizarion interface [polypeptide binding]; other site 357348016100 CrgA pocket; other site 357348016101 substrate binding pocket [chemical binding]; other site 357348016102 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 357348016103 Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542 357348016104 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 357348016105 putative alpha subunit interface [polypeptide binding]; other site 357348016106 putative active site [active] 357348016107 putative substrate binding site [chemical binding]; other site 357348016108 Fe binding site [ion binding]; other site 357348016109 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 357348016110 inter-subunit interface; other site 357348016111 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 357348016112 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 357348016113 catalytic loop [active] 357348016114 iron binding site [ion binding]; other site 357348016115 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 357348016116 FAD binding pocket [chemical binding]; other site 357348016117 FAD binding motif [chemical binding]; other site 357348016118 phosphate binding motif [ion binding]; other site 357348016119 beta-alpha-beta structure motif; other site 357348016120 NAD binding pocket [chemical binding]; other site 357348016121 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 357348016122 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937 357348016123 putative NAD(P) binding site [chemical binding]; other site 357348016124 active site 357348016125 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 357348016126 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 357348016127 nucleophilic elbow; other site 357348016128 catalytic triad; other site 357348016129 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 357348016130 Isochorismatase family; Region: Isochorismatase; pfam00857 357348016131 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 357348016132 catalytic triad [active] 357348016133 conserved cis-peptide bond; other site 357348016134 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 357348016135 Asp-box motif; other site 357348016136 lysine transporter; Provisional; Region: PRK10836 357348016137 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 357348016138 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 357348016139 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 357348016140 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 357348016141 Beta-Casp domain; Region: Beta-Casp; smart01027 357348016142 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 357348016143 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 357348016144 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 357348016145 NAD(P) binding site [chemical binding]; other site 357348016146 homotetramer interface [polypeptide binding]; other site 357348016147 homodimer interface [polypeptide binding]; other site 357348016148 active site 357348016149 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 357348016150 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 357348016151 ligand binding site [chemical binding]; other site 357348016152 flexible hinge region; other site 357348016153 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 357348016154 putative switch regulator; other site 357348016155 non-specific DNA interactions [nucleotide binding]; other site 357348016156 DNA binding site [nucleotide binding] 357348016157 sequence specific DNA binding site [nucleotide binding]; other site 357348016158 putative cAMP binding site [chemical binding]; other site 357348016159 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 357348016160 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 357348016161 putative NAD(P) binding site [chemical binding]; other site 357348016162 putative substrate binding site [chemical binding]; other site 357348016163 catalytic Zn binding site [ion binding]; other site 357348016164 structural Zn binding site [ion binding]; other site 357348016165 Protein of unknown function (DUF3562); Region: DUF3562; pfam12085 357348016166 Protein of unknown function (DUF3564); Region: DUF3564; pfam12087 357348016167 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 357348016168 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 357348016169 BON domain; Region: BON; pfam04972 357348016170 BON domain; Region: BON; pfam04972 357348016171 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 357348016172 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 357348016173 ligand-binding site [chemical binding]; other site 357348016174 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 357348016175 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 357348016176 dimer interface [polypeptide binding]; other site 357348016177 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 357348016178 putative CheW interface [polypeptide binding]; other site 357348016179 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 357348016180 putative active site [active] 357348016181 putative metal binding site [ion binding]; other site 357348016182 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 357348016183 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 357348016184 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 357348016185 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 357348016186 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 357348016187 Walker A/P-loop; other site 357348016188 ATP binding site [chemical binding]; other site 357348016189 Q-loop/lid; other site 357348016190 ABC transporter signature motif; other site 357348016191 Walker B; other site 357348016192 D-loop; other site 357348016193 H-loop/switch region; other site 357348016194 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 357348016195 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 357348016196 FtsX-like permease family; Region: FtsX; pfam02687 357348016197 Protein of unknown function (DUF2964); Region: DUF2964; pfam11177 357348016198 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 357348016199 Ligand Binding Site [chemical binding]; other site 357348016200 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 357348016201 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 357348016202 HlyD family secretion protein; Region: HlyD; pfam00529 357348016203 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 357348016204 Proteobacterial lipase chaperone protein; Region: Lipase_chap; cl02224 357348016205 HlyD family secretion protein; Region: HlyD_3; pfam13437 357348016206 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 357348016207 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 357348016208 Walker A/P-loop; other site 357348016209 ATP binding site [chemical binding]; other site 357348016210 Q-loop/lid; other site 357348016211 ABC transporter signature motif; other site 357348016212 Walker B; other site 357348016213 D-loop; other site 357348016214 H-loop/switch region; other site 357348016215 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 357348016216 Walker A/P-loop; other site 357348016217 ATP binding site [chemical binding]; other site 357348016218 Q-loop/lid; other site 357348016219 ABC transporter signature motif; other site 357348016220 Walker B; other site 357348016221 D-loop; other site 357348016222 H-loop/switch region; other site 357348016223 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 357348016224 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 357348016225 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 357348016226 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 357348016227 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 357348016228 PAS fold; Region: PAS_4; pfam08448 357348016229 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357348016230 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357348016231 dimer interface [polypeptide binding]; other site 357348016232 phosphorylation site [posttranslational modification] 357348016233 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357348016234 ATP binding site [chemical binding]; other site 357348016235 Mg2+ binding site [ion binding]; other site 357348016236 G-X-G motif; other site 357348016237 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 357348016238 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348016239 active site 357348016240 phosphorylation site [posttranslational modification] 357348016241 intermolecular recognition site; other site 357348016242 dimerization interface [polypeptide binding]; other site 357348016243 Cache domain; Region: Cache_2; pfam08269 357348016244 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 357348016245 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 357348016246 dimer interface [polypeptide binding]; other site 357348016247 putative CheW interface [polypeptide binding]; other site 357348016248 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 357348016249 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 357348016250 NAD binding site [chemical binding]; other site 357348016251 substrate binding site [chemical binding]; other site 357348016252 catalytic Zn binding site [ion binding]; other site 357348016253 tetramer interface [polypeptide binding]; other site 357348016254 structural Zn binding site [ion binding]; other site 357348016255 ATP synthase; Region: ATP-synt; pfam00231 357348016256 core domain interface [polypeptide binding]; other site 357348016257 delta subunit interface [polypeptide binding]; other site 357348016258 epsilon subunit interface [polypeptide binding]; other site 357348016259 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 357348016260 type III secretion apparatus H+-transporting two-sector ATPase; Region: III_secr_ATP; TIGR02546 357348016261 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 357348016262 Walker A motif; other site 357348016263 ATP binding site [chemical binding]; other site 357348016264 Walker B motif; other site 357348016265 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 357348016266 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 357348016267 F0F1 ATP synthase subunit C; Provisional; Region: PRK13468 357348016268 F0F1 ATP synthase subunit A; Provisional; Region: PRK13421 357348016269 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 357348016270 F0F1 ATP synthase subunit epsilon; Provisional; Region: PRK13447 357348016271 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 357348016272 gamma subunit interface [polypeptide binding]; other site 357348016273 epsilon subunit interface [polypeptide binding]; other site 357348016274 LBP interface [polypeptide binding]; other site 357348016275 F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597 357348016276 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 357348016277 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 357348016278 alpha subunit interaction interface [polypeptide binding]; other site 357348016279 Walker A motif; other site 357348016280 ATP binding site [chemical binding]; other site 357348016281 Walker B motif; other site 357348016282 inhibitor binding site; inhibition site 357348016283 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 357348016284 Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551 357348016285 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 357348016286 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 357348016287 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190 357348016288 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 357348016289 dimer interaction site [polypeptide binding]; other site 357348016290 substrate-binding tunnel; other site 357348016291 active site 357348016292 catalytic site [active] 357348016293 substrate binding site [chemical binding]; other site 357348016294 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 357348016295 acetate kinase; Provisional; Region: PRK07058 357348016296 propionate/acetate kinase; Provisional; Region: PRK12379 357348016297 6-phosphofructokinase 2; Provisional; Region: PRK10294 357348016298 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 357348016299 putative substrate binding site [chemical binding]; other site 357348016300 putative ATP binding site [chemical binding]; other site 357348016301 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 357348016302 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 357348016303 BON domain; Region: BON; pfam04972 357348016304 BON domain; Region: BON; pfam04972 357348016305 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 357348016306 active site 357348016307 catalytic motif [active] 357348016308 Zn binding site [ion binding]; other site 357348016309 thymidine phosphorylase; Region: T_phosphoryl; TIGR02643 357348016310 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 357348016311 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 357348016312 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 357348016313 deoxyribose-phosphate aldolase; Provisional; Region: PRK05283 357348016314 catalytic residue [active] 357348016315 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 357348016316 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 357348016317 Nucleoside recognition; Region: Gate; pfam07670 357348016318 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 357348016319 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 357348016320 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 357348016321 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 357348016322 putative C-terminal domain interface [polypeptide binding]; other site 357348016323 putative GSH binding site (G-site) [chemical binding]; other site 357348016324 putative dimer interface [polypeptide binding]; other site 357348016325 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 357348016326 putative N-terminal domain interface [polypeptide binding]; other site 357348016327 putative dimer interface [polypeptide binding]; other site 357348016328 putative substrate binding pocket (H-site) [chemical binding]; other site 357348016329 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357348016330 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348016331 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 357348016332 putative effector binding pocket; other site 357348016333 dimerization interface [polypeptide binding]; other site 357348016334 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 357348016335 short chain dehydrogenase; Provisional; Region: PRK06181 357348016336 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357348016337 NAD(P) binding site [chemical binding]; other site 357348016338 active site 357348016339 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 357348016340 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 357348016341 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 357348016342 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 357348016343 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 357348016344 metal binding site [ion binding]; metal-binding site 357348016345 active site 357348016346 I-site; other site 357348016347 Protein of unknown function (DUF3268); Region: DUF3268; pfam11672 357348016348 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 357348016349 peptidase domain interface [polypeptide binding]; other site 357348016350 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 357348016351 active site 357348016352 catalytic triad [active] 357348016353 calcium binding site [ion binding]; other site 357348016354 Phospholipid methyltransferase; Region: PEMT; cl17370 357348016355 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 357348016356 cryptic autophosphorylating protein tyrosine kinase Etk; Provisional; Region: PRK09841 357348016357 Chain length determinant protein; Region: Wzz; pfam02706 357348016358 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 357348016359 Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790 357348016360 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 357348016361 putative metal binding site [ion binding]; other site 357348016362 putative homodimer interface [polypeptide binding]; other site 357348016363 putative homotetramer interface [polypeptide binding]; other site 357348016364 putative homodimer-homodimer interface [polypeptide binding]; other site 357348016365 putative allosteric switch controlling residues; other site 357348016366 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 357348016367 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 357348016368 Catalytic domain, repeat 1, of Deoxyribonuclease II and similar proteins; Region: PLDc_DNaseII_1; cd09120 357348016369 Deoxyribonuclease II; Region: DNase_II; pfam03265 357348016370 putative active site [active] 357348016371 catalytic site [active] 357348016372 Catalytic domain, repeat 2, of Deoxyribonuclease II and similar proteins; Region: PLDc_DNaseII_2; cd09121 357348016373 putative active site [active] 357348016374 catalytic site [active] 357348016375 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 357348016376 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 357348016377 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 357348016378 active site 357348016379 metal binding site [ion binding]; metal-binding site 357348016380 Ferritin-like; Region: Ferritin-like; pfam12902 357348016381 aldolase II superfamily protein; Provisional; Region: PRK07044 357348016382 intersubunit interface [polypeptide binding]; other site 357348016383 active site 357348016384 Zn2+ binding site [ion binding]; other site 357348016385 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 357348016386 putative uracil binding site [chemical binding]; other site 357348016387 putative active site [active] 357348016388 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 357348016389 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 357348016390 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 357348016391 active site 357348016392 catalytic triad [active] 357348016393 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 357348016394 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348016395 active site 357348016396 phosphorylation site [posttranslational modification] 357348016397 intermolecular recognition site; other site 357348016398 dimerization interface [polypeptide binding]; other site 357348016399 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 357348016400 DNA binding site [nucleotide binding] 357348016401 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 357348016402 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 357348016403 dimerization interface [polypeptide binding]; other site 357348016404 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357348016405 dimer interface [polypeptide binding]; other site 357348016406 phosphorylation site [posttranslational modification] 357348016407 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357348016408 ATP binding site [chemical binding]; other site 357348016409 Mg2+ binding site [ion binding]; other site 357348016410 G-X-G motif; other site 357348016411 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 357348016412 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 357348016413 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 357348016414 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 357348016415 Phosphoesterase family; Region: Phosphoesterase; pfam04185 357348016416 Iron permease FTR1 family; Region: FTR1; cl00475 357348016417 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 357348016418 CTP synthase; Region: PyrG; TIGR00337 357348016419 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 357348016420 substrate binding pocket [chemical binding]; other site 357348016421 membrane-bound complex binding site; other site 357348016422 hinge residues; other site 357348016423 Predicted metal-binding protein [General function prediction only]; Region: COG3019 357348016424 Transposase; Region: HTH_Tnp_1; pfam01527 357348016425 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 357348016426 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 357348016427 Domain of unknown function (DUF1864); Region: DUF1864; pfam08933 357348016428 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 357348016429 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 357348016430 This alignment model represents the N-terminal rieske domain of the oxygenase alpha subunit of aminopyrrolnitrin oxygenase (PrnD). PrnD is a novel Rieske N-oxygenase that catalyzes the final step in the pyrrolnitrin biosynthetic pathway, the oxidation...; Region: Rieske_RO_Alpha_PrnD; cd03537 357348016431 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 357348016432 Transposase, Mutator family; Region: Transposase_mut; pfam00872 357348016433 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 357348016434 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 357348016435 glutaminase active site [active] 357348016436 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 357348016437 dimer interface [polypeptide binding]; other site 357348016438 active site 357348016439 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 357348016440 dimer interface [polypeptide binding]; other site 357348016441 active site 357348016442 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 357348016443 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 357348016444 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 357348016445 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 357348016446 DXD motif; other site 357348016447 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 357348016448 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 357348016449 active site 357348016450 homodimer interface [polypeptide binding]; other site 357348016451 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 357348016452 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348016453 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 357348016454 dimerization interface [polypeptide binding]; other site 357348016455 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 357348016456 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 357348016457 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828 357348016458 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 357348016459 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 357348016460 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 357348016461 catalytic residue [active] 357348016462 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 357348016463 D-mannose binding lectin; Region: B_lectin; pfam01453 357348016464 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 357348016465 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 357348016466 NAD binding site [chemical binding]; other site 357348016467 catalytic Zn binding site [ion binding]; other site 357348016468 structural Zn binding site [ion binding]; other site 357348016469 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 357348016470 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 357348016471 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 357348016472 catalytic residue [active] 357348016473 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_2; cd07805 357348016474 N- and C-terminal domain interface [polypeptide binding]; other site 357348016475 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 357348016476 active site 357348016477 MgATP binding site [chemical binding]; other site 357348016478 catalytic site [active] 357348016479 metal binding site [ion binding]; metal-binding site 357348016480 xylulose binding site [chemical binding]; other site 357348016481 putative homodimer interface [polypeptide binding]; other site 357348016482 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 357348016483 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 357348016484 Transposase domain (DUF772); Region: DUF772; pfam05598 357348016485 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 357348016486 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 357348016487 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 357348016488 active site 357348016489 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 357348016490 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 357348016491 NAD(P) binding site [chemical binding]; other site 357348016492 substrate binding site [chemical binding]; other site 357348016493 homotetramer interface [polypeptide binding]; other site 357348016494 active site 357348016495 homodimer interface [polypeptide binding]; other site 357348016496 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 357348016497 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 357348016498 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 357348016499 active site 357348016500 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 357348016501 enoyl-CoA hydratase; Provisional; Region: PRK07468 357348016502 substrate binding site [chemical binding]; other site 357348016503 oxyanion hole (OAH) forming residues; other site 357348016504 trimer interface [polypeptide binding]; other site 357348016505 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 357348016506 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 357348016507 ATP-grasp domain; Region: ATP-grasp_4; cl17255 357348016508 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 357348016509 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 357348016510 carboxyltransferase (CT) interaction site; other site 357348016511 biotinylation site [posttranslational modification]; other site 357348016512 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 357348016513 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 357348016514 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 357348016515 acyl-activating enzyme (AAE) consensus motif; other site 357348016516 AMP binding site [chemical binding]; other site 357348016517 active site 357348016518 CoA binding site [chemical binding]; other site 357348016519 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 357348016520 Fatty acid desaturase; Region: FA_desaturase; pfam00487 357348016521 Di-iron ligands [ion binding]; other site 357348016522 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 357348016523 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 357348016524 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 357348016525 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357348016526 S-adenosylmethionine binding site [chemical binding]; other site 357348016527 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 357348016528 Fatty acid desaturase; Region: FA_desaturase; pfam00487 357348016529 Di-iron ligands [ion binding]; other site 357348016530 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 357348016531 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 357348016532 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 357348016533 active site 357348016534 acyl-CoA synthetase; Validated; Region: PRK05850 357348016535 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 357348016536 acyl-activating enzyme (AAE) consensus motif; other site 357348016537 active site 357348016538 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 357348016539 CoenzymeA binding site [chemical binding]; other site 357348016540 subunit interaction site [polypeptide binding]; other site 357348016541 PHB binding site; other site 357348016542 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 357348016543 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 357348016544 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 357348016545 dimer interface [polypeptide binding]; other site 357348016546 ADP-ribose binding site [chemical binding]; other site 357348016547 active site 357348016548 nudix motif; other site 357348016549 metal binding site [ion binding]; metal-binding site 357348016550 DDE domain; Region: DDE_Tnp_IS240; pfam13610 357348016551 Protein of unknown function (DUF1153); Region: DUF1153; pfam06627 357348016552 HTH-like domain; Region: HTH_21; pfam13276 357348016553 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 357348016554 Integrase core domain; Region: rve; pfam00665 357348016555 Integrase core domain; Region: rve_3; pfam13683 357348016556 Transposase; Region: HTH_Tnp_1; pfam01527 357348016557 Domain of Unknown Function (DUF746); Region: DUF746; pfam05344 357348016558 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 357348016559 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 357348016560 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 357348016561 haemagglutination activity domain; Region: Haemagg_act; pfam05860 357348016562 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 357348016563 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 357348016564 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 357348016565 RHS Repeat; Region: RHS_repeat; pfam05593 357348016566 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 357348016567 RHS Repeat; Region: RHS_repeat; pfam05593 357348016568 RHS Repeat; Region: RHS_repeat; pfam05593 357348016569 RHS Repeat; Region: RHS_repeat; pfam05593 357348016570 RHS Repeat; Region: RHS_repeat; pfam05593 357348016571 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 357348016572 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 357348016573 RHS Repeat; Region: RHS_repeat; cl11982 357348016574 RHS Repeat; Region: RHS_repeat; pfam05593 357348016575 RHS protein; Region: RHS; pfam03527 357348016576 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 357348016577 SCP1.201-like deaminase; Region: SCP1201-deam; pfam14428 357348016578 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 357348016579 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 357348016580 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 357348016581 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 357348016582 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 357348016583 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 357348016584 Transposase; Region: HTH_Tnp_1; pfam01527 357348016585 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 357348016586 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 357348016587 Melibiase; Region: Melibiase; pfam02065 357348016588 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 357348016589 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348016590 dimer interface [polypeptide binding]; other site 357348016591 conserved gate region; other site 357348016592 putative PBP binding loops; other site 357348016593 ABC-ATPase subunit interface; other site 357348016594 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 357348016595 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348016596 dimer interface [polypeptide binding]; other site 357348016597 conserved gate region; other site 357348016598 putative PBP binding loops; other site 357348016599 ABC-ATPase subunit interface; other site 357348016600 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 357348016601 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 357348016602 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 357348016603 Transcriptional regulators [Transcription]; Region: PurR; COG1609 357348016604 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 357348016605 DNA binding site [nucleotide binding] 357348016606 domain linker motif; other site 357348016607 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 357348016608 dimerization interface [polypeptide binding]; other site 357348016609 ligand binding site [chemical binding]; other site 357348016610 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 357348016611 RHS Repeat; Region: RHS_repeat; cl11982 357348016612 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 357348016613 RHS Repeat; Region: RHS_repeat; pfam05593 357348016614 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 357348016615 Domain of Unknown Function (DUF746); Region: DUF746; pfam05344 357348016616 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 357348016617 Domain of Unknown Function (DUF746); Region: DUF746; pfam05344 357348016618 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 357348016619 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 357348016620 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 357348016621 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 357348016622 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 357348016623 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357348016624 Walker A motif; other site 357348016625 ATP binding site [chemical binding]; other site 357348016626 Walker B motif; other site 357348016627 arginine finger; other site 357348016628 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357348016629 Walker A motif; other site 357348016630 ATP binding site [chemical binding]; other site 357348016631 Walker B motif; other site 357348016632 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 357348016633 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 357348016634 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 357348016635 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 357348016636 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 357348016637 Protein of unknown function (DUF796); Region: DUF796; pfam05638 357348016638 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 357348016639 Protein of unknown function (DUF877); Region: DUF877; pfam05943 357348016640 Protein of unknown function (DUF770); Region: DUF770; pfam05591 357348016641 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 357348016642 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 357348016643 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 357348016644 Catalytic domain of Protein Kinases; Region: PKc; cd00180 357348016645 active site 357348016646 ATP binding site [chemical binding]; other site 357348016647 substrate binding site [chemical binding]; other site 357348016648 activation loop (A-loop); other site 357348016649 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; pfam09867 357348016650 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 357348016651 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 357348016652 G1 box; other site 357348016653 GTP/Mg2+ binding site [chemical binding]; other site 357348016654 G2 box; other site 357348016655 G3 box; other site 357348016656 Switch II region; other site 357348016657 G4 box; other site 357348016658 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 357348016659 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 357348016660 hypothetical protein; Provisional; Region: PRK07033 357348016661 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 357348016662 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 357348016663 ligand binding site [chemical binding]; other site 357348016664 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 357348016665 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 357348016666 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 357348016667 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 357348016668 phosphopeptide binding site; other site 357348016669 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 357348016670 hypothetical protein; Provisional; Region: PRK07538 357348016671 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 357348016672 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 357348016673 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 357348016674 NAD(P) binding site [chemical binding]; other site 357348016675 active site 357348016676 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 357348016677 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348016678 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 357348016679 dimerization interface [polypeptide binding]; other site 357348016680 substrate binding pocket [chemical binding]; other site 357348016681 D-serine dehydratase; Provisional; Region: PRK02991 357348016682 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 357348016683 catalytic residue [active] 357348016684 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 357348016685 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348016686 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 357348016687 dimerization interface [polypeptide binding]; other site 357348016688 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 357348016689 dimerization interface [polypeptide binding]; other site 357348016690 putative DNA binding site [nucleotide binding]; other site 357348016691 putative Zn2+ binding site [ion binding]; other site 357348016692 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 357348016693 active site residue [active] 357348016694 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 357348016695 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348016696 Major Facilitator Superfamily; Region: MFS_1; pfam07690 357348016697 putative substrate translocation pore; other site 357348016698 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 357348016699 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 357348016700 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 357348016701 catalytic residue [active] 357348016702 metabolite-proton symporter; Region: 2A0106; TIGR00883 357348016703 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348016704 putative substrate translocation pore; other site 357348016705 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348016706 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 357348016707 dimerization interface [polypeptide binding]; other site 357348016708 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 357348016709 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 357348016710 phosphate binding site [ion binding]; other site 357348016711 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 357348016712 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 357348016713 Transcriptional regulator [Transcription]; Region: IclR; COG1414 357348016714 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 357348016715 Bacterial transcriptional regulator; Region: IclR; pfam01614 357348016716 indole acetimide hydrolase; Validated; Region: PRK07488 357348016717 Amidase; Region: Amidase; pfam01425 357348016718 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 357348016719 CoA binding domain; Region: CoA_binding_2; pfam13380 357348016720 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 357348016721 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 357348016722 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 357348016723 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357348016724 Coenzyme A binding pocket [chemical binding]; other site 357348016725 H-NS histone family; Region: Histone_HNS; pfam00816 357348016726 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 357348016727 PAS fold; Region: PAS_4; pfam08448 357348016728 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 357348016729 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357348016730 Walker B motif; other site 357348016731 arginine finger; other site 357348016732 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 357348016733 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 357348016734 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 357348016735 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 357348016736 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 357348016737 active site residue [active] 357348016738 outer membrane porin, OprD family; Region: OprD; pfam03573 357348016739 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 357348016740 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 357348016741 Walker A/P-loop; other site 357348016742 ATP binding site [chemical binding]; other site 357348016743 Q-loop/lid; other site 357348016744 ABC transporter signature motif; other site 357348016745 Walker B; other site 357348016746 D-loop; other site 357348016747 H-loop/switch region; other site 357348016748 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 357348016749 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 357348016750 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 357348016751 Walker A/P-loop; other site 357348016752 ATP binding site [chemical binding]; other site 357348016753 Q-loop/lid; other site 357348016754 ABC transporter signature motif; other site 357348016755 Walker B; other site 357348016756 D-loop; other site 357348016757 H-loop/switch region; other site 357348016758 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 357348016759 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 357348016760 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348016761 dimer interface [polypeptide binding]; other site 357348016762 conserved gate region; other site 357348016763 putative PBP binding loops; other site 357348016764 ABC-ATPase subunit interface; other site 357348016765 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 357348016766 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348016767 dimer interface [polypeptide binding]; other site 357348016768 conserved gate region; other site 357348016769 putative PBP binding loops; other site 357348016770 ABC-ATPase subunit interface; other site 357348016771 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 357348016772 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 357348016773 peptide binding site [polypeptide binding]; other site 357348016774 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 357348016775 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 357348016776 non-specific DNA binding site [nucleotide binding]; other site 357348016777 salt bridge; other site 357348016778 sequence-specific DNA binding site [nucleotide binding]; other site 357348016779 Cupin domain; Region: Cupin_2; pfam07883 357348016780 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 357348016781 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348016782 putative substrate translocation pore; other site 357348016783 POT family; Region: PTR2; cl17359 357348016784 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 357348016785 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 357348016786 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348016787 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 357348016788 substrate binding pocket [chemical binding]; other site 357348016789 dimerization interface [polypeptide binding]; other site 357348016790 Putative cyclase; Region: Cyclase; cl00814 357348016791 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 357348016792 CoA-transferase family III; Region: CoA_transf_3; pfam02515 357348016793 Transcriptional regulator [Transcription]; Region: IclR; COG1414 357348016794 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 357348016795 Bacterial transcriptional regulator; Region: IclR; pfam01614 357348016796 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 357348016797 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 357348016798 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 357348016799 trimer interface [polypeptide binding]; other site 357348016800 eyelet of channel; other site 357348016801 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 357348016802 2-methylcitrate dehydratase; Region: prpD; TIGR02330 357348016803 OpgC protein; Region: OpgC_C; pfam10129 357348016804 Protein kinase essential for the initiation of DNA replication [DNA replication, recombination, and repair / Cell division and chromosome partitioning]; Region: DBF4; COG5067 357348016805 Predicted permeases [General function prediction only]; Region: RarD; COG2962 357348016806 acylphosphatase; Provisional; Region: PRK14424 357348016807 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 357348016808 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 357348016809 putative NADP binding site [chemical binding]; other site 357348016810 putative substrate binding site [chemical binding]; other site 357348016811 active site 357348016812 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 357348016813 active site 357348016814 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 357348016815 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 357348016816 LytB protein; Region: LYTB; pfam02401 357348016817 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 357348016818 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 357348016819 FeS/SAM binding site; other site 357348016820 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 357348016821 Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; pfam08883 357348016822 aminotransferase; Validated; Region: PRK07046 357348016823 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 357348016824 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 357348016825 catalytic residue [active] 357348016826 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 357348016827 sequence-specific DNA binding site [nucleotide binding]; other site 357348016828 salt bridge; other site 357348016829 Protein of unknown function (DUF466); Region: DUF466; pfam04328 357348016830 carbon starvation protein A; Provisional; Region: PRK15015 357348016831 Carbon starvation protein CstA; Region: CstA; pfam02554 357348016832 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 357348016833 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 357348016834 Uncharacterized conserved protein [Function unknown]; Region: COG5476 357348016835 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 357348016836 MlrC C-terminus; Region: MlrC_C; pfam07171 357348016837 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357348016838 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348016839 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 357348016840 dimerization interface [polypeptide binding]; other site 357348016841 ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha); and similar proteins; Region: ChaP_like; cd08351 357348016842 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 357348016843 metal binding site [ion binding]; metal-binding site 357348016844 SnoaL-like domain; Region: SnoaL_2; pfam12680 357348016845 Predicted membrane protein [Function unknown]; Region: COG2246 357348016846 GtrA-like protein; Region: GtrA; pfam04138 357348016847 Methyltransferase domain; Region: Methyltransf_23; pfam13489 357348016848 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 357348016849 S-adenosylmethionine binding site [chemical binding]; other site 357348016850 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 357348016851 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 357348016852 Ligand binding site; other site 357348016853 Putative Catalytic site; other site 357348016854 DXD motif; other site 357348016855 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 357348016856 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 357348016857 Flp/Fap pilin component; Region: Flp_Fap; cl01585 357348016858 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 357348016859 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 357348016860 active site 357348016861 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 357348016862 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 357348016863 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 357348016864 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 357348016865 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 357348016866 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 357348016867 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 357348016868 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 357348016869 TadE-like protein; Region: TadE; pfam07811 357348016870 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 357348016871 TadE-like protein; Region: TadE; pfam07811 357348016872 AAA domain; Region: AAA_31; pfam13614 357348016873 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 357348016874 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 357348016875 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 357348016876 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 357348016877 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 357348016878 ATP binding site [chemical binding]; other site 357348016879 Walker A motif; other site 357348016880 hexamer interface [polypeptide binding]; other site 357348016881 Walker B motif; other site 357348016882 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 357348016883 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 357348016884 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 357348016885 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 357348016886 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 357348016887 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 357348016888 putative DNA binding site [nucleotide binding]; other site 357348016889 putative Zn2+ binding site [ion binding]; other site 357348016890 AsnC family; Region: AsnC_trans_reg; pfam01037 357348016891 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 357348016892 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 357348016893 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348016894 homodimer interface [polypeptide binding]; other site 357348016895 catalytic residue [active] 357348016896 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 357348016897 homotrimer interaction site [polypeptide binding]; other site 357348016898 putative active site [active] 357348016899 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 357348016900 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 357348016901 trimer interface [polypeptide binding]; other site 357348016902 eyelet of channel; other site 357348016903 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 357348016904 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 357348016905 DNA-binding site [nucleotide binding]; DNA binding site 357348016906 Transcriptional regulators [Transcription]; Region: FadR; COG2186 357348016907 Uncharacterized conserved protein [Function unknown]; Region: COG5476 357348016908 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 357348016909 MlrC C-terminus; Region: MlrC_C; pfam07171 357348016910 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 357348016911 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348016912 putative substrate translocation pore; other site 357348016913 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357348016914 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348016915 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 357348016916 dimerization interface [polypeptide binding]; other site 357348016917 Protein of unknown function (DUF3175); Region: DUF3175; pfam11373 357348016918 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 357348016919 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 357348016920 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 357348016921 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 357348016922 active site 357348016923 DNA binding site [nucleotide binding] 357348016924 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 357348016925 DNA binding site [nucleotide binding] 357348016926 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 357348016927 nucleotide binding site [chemical binding]; other site 357348016928 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 357348016929 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 357348016930 putative DNA binding site [nucleotide binding]; other site 357348016931 putative homodimer interface [polypeptide binding]; other site 357348016932 Predicted membrane protein [Function unknown]; Region: COG2323 357348016933 hydroperoxidase II; Provisional; Region: katE; PRK11249 357348016934 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 357348016935 tetramer interface [polypeptide binding]; other site 357348016936 heme binding pocket [chemical binding]; other site 357348016937 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 357348016938 domain interactions; other site 357348016939 Protein of unknown function (DUF3022); Region: DUF3022; pfam11226 357348016940 RNA polymerase factor sigma-54; Provisional; Region: PRK12469 357348016941 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 357348016942 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 357348016943 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 357348016944 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 357348016945 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 357348016946 dimanganese center [ion binding]; other site 357348016947 Domain of unknown function (DUF892); Region: DUF892; pfam05974 357348016948 Protein of unknown function (DUF3005); Region: DUF3005; pfam11448 357348016949 MltA-interacting protein MipA; Region: MipA; cl01504 357348016950 FOG: CBS domain [General function prediction only]; Region: COG0517 357348016951 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 357348016952 PRC-barrel domain; Region: PRC; pfam05239 357348016953 Response regulator receiver domain; Region: Response_reg; pfam00072 357348016954 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348016955 active site 357348016956 phosphorylation site [posttranslational modification] 357348016957 intermolecular recognition site; other site 357348016958 dimerization interface [polypeptide binding]; other site 357348016959 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 357348016960 Fe-S cluster binding site [ion binding]; other site 357348016961 active site 357348016962 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 357348016963 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 357348016964 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 357348016965 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 357348016966 NAD binding site [chemical binding]; other site 357348016967 catalytic Zn binding site [ion binding]; other site 357348016968 structural Zn binding site [ion binding]; other site 357348016969 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 357348016970 short chain dehydrogenase; Provisional; Region: PRK06701 357348016971 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 357348016972 NAD binding site [chemical binding]; other site 357348016973 metal binding site [ion binding]; metal-binding site 357348016974 active site 357348016975 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 357348016976 short chain dehydrogenase; Provisional; Region: PRK07109 357348016977 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 357348016978 putative NAD(P) binding site [chemical binding]; other site 357348016979 active site 357348016980 BON domain; Region: BON; pfam04972 357348016981 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 357348016982 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 357348016983 putative ADP-binding pocket [chemical binding]; other site 357348016984 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 357348016985 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 357348016986 NAD binding site [chemical binding]; other site 357348016987 putative substrate binding site 2 [chemical binding]; other site 357348016988 putative substrate binding site 1 [chemical binding]; other site 357348016989 active site 357348016990 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 357348016991 PAS domain; Region: PAS_9; pfam13426 357348016992 putative active site [active] 357348016993 heme pocket [chemical binding]; other site 357348016994 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 357348016995 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 357348016996 putative active site [active] 357348016997 heme pocket [chemical binding]; other site 357348016998 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357348016999 dimer interface [polypeptide binding]; other site 357348017000 phosphorylation site [posttranslational modification] 357348017001 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357348017002 ATP binding site [chemical binding]; other site 357348017003 Mg2+ binding site [ion binding]; other site 357348017004 G-X-G motif; other site 357348017005 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 357348017006 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348017007 active site 357348017008 phosphorylation site [posttranslational modification] 357348017009 intermolecular recognition site; other site 357348017010 dimerization interface [polypeptide binding]; other site 357348017011 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 357348017012 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 357348017013 active site 357348017014 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 357348017015 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348017016 active site 357348017017 phosphorylation site [posttranslational modification] 357348017018 intermolecular recognition site; other site 357348017019 dimerization interface [polypeptide binding]; other site 357348017020 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357348017021 Walker A motif; other site 357348017022 ATP binding site [chemical binding]; other site 357348017023 Walker B motif; other site 357348017024 arginine finger; other site 357348017025 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 357348017026 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 357348017027 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 357348017028 Walker A motif; other site 357348017029 ATP binding site [chemical binding]; other site 357348017030 Walker B motif; other site 357348017031 arginine finger; other site 357348017032 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 357348017033 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 357348017034 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 357348017035 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 357348017036 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 357348017037 putative active site [active] 357348017038 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 357348017039 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 357348017040 active site 357348017041 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 357348017042 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 357348017043 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 357348017044 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 357348017045 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 357348017046 putative active site [active] 357348017047 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 357348017048 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 357348017049 active site 357348017050 motif I; other site 357348017051 motif II; other site 357348017052 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 357348017053 classical (c) SDRs; Region: SDR_c; cd05233 357348017054 NAD(P) binding site [chemical binding]; other site 357348017055 active site 357348017056 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 357348017057 Transposase; Region: DDE_Tnp_ISL3; pfam01610 357348017058 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 357348017059 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 357348017060 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357348017061 Walker A/P-loop; other site 357348017062 ATP binding site [chemical binding]; other site 357348017063 Q-loop/lid; other site 357348017064 ABC transporter signature motif; other site 357348017065 Walker B; other site 357348017066 D-loop; other site 357348017067 H-loop/switch region; other site 357348017068 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 357348017069 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348017070 Response regulator receiver domain; Region: Response_reg; pfam00072 357348017071 active site 357348017072 phosphorylation site [posttranslational modification] 357348017073 intermolecular recognition site; other site 357348017074 dimerization interface [polypeptide binding]; other site 357348017075 BON domain; Region: BON; pfam04972 357348017076 Phophatidylserine decarboxylase; Region: PSDC; pfam12588 357348017077 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; pfam02666 357348017078 succinate dehydrogenase iron-sulfur subunit; Provisional; Region: PRK12575 357348017079 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 357348017080 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 357348017081 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 357348017082 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 357348017083 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 357348017084 active site 357348017085 non-prolyl cis peptide bond; other site 357348017086 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 357348017087 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 357348017088 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 357348017089 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348017090 putative substrate translocation pore; other site 357348017091 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 357348017092 Autoinducer binding domain; Region: Autoind_bind; pfam03472 357348017093 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 357348017094 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 357348017095 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 357348017096 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 357348017097 E3 interaction surface; other site 357348017098 lipoyl attachment site [posttranslational modification]; other site 357348017099 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 357348017100 e3 binding domain; Region: E3_binding; pfam02817 357348017101 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 357348017102 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 357348017103 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 357348017104 alpha subunit interface [polypeptide binding]; other site 357348017105 TPP binding site [chemical binding]; other site 357348017106 heterodimer interface [polypeptide binding]; other site 357348017107 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 357348017108 2-oxoisovalerate dehydrogenase E1 alpha subunit N terminal; Region: OxoDH_E1alpha_N; pfam12573 357348017109 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 357348017110 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 357348017111 tetramer interface [polypeptide binding]; other site 357348017112 TPP-binding site [chemical binding]; other site 357348017113 heterodimer interface [polypeptide binding]; other site 357348017114 phosphorylation loop region [posttranslational modification] 357348017115 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 357348017116 putative hydrophobic ligand binding site [chemical binding]; other site 357348017117 protein interface [polypeptide binding]; other site 357348017118 gate; other site 357348017119 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 357348017120 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 357348017121 hydrophobic ligand binding site; other site 357348017122 Transcriptional regulator [Transcription]; Region: LysR; COG0583 357348017123 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 357348017124 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 357348017125 substrate binding pocket [chemical binding]; other site 357348017126 dimerization interface [polypeptide binding]; other site 357348017127 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 357348017128 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 357348017129 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 357348017130 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 357348017131 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 357348017132 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 357348017133 nucleophile elbow; other site 357348017134 Patatin phospholipase; Region: DUF3734; pfam12536 357348017135 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 357348017136 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 357348017137 ribonucleotide reductase-like protein; Provisional; Region: PRK06948 357348017138 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 357348017139 active site 357348017140 dimer interface [polypeptide binding]; other site 357348017141 effector binding site; other site 357348017142 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 357348017143 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 357348017144 AAA domain; Region: AAA_33; pfam13671 357348017145 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 357348017146 FMN binding site [chemical binding]; other site 357348017147 dimer interface [polypeptide binding]; other site 357348017148 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 357348017149 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 357348017150 Sulfate transporter family; Region: Sulfate_transp; pfam00916 357348017151 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 357348017152 FOG: CBS domain [General function prediction only]; Region: COG0517 357348017153 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 357348017154 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 357348017155 putative FMN binding site [chemical binding]; other site 357348017156 NADPH bind site [chemical binding]; other site 357348017157 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 357348017158 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 357348017159 putative dimer interface [polypeptide binding]; other site 357348017160 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 357348017161 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 357348017162 trimer interface [polypeptide binding]; other site 357348017163 eyelet of channel; other site 357348017164 putative acyl-CoA synthetase; Provisional; Region: PRK06018 357348017165 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 357348017166 acyl-activating enzyme (AAE) consensus motif; other site 357348017167 AMP binding site [chemical binding]; other site 357348017168 active site 357348017169 CoA binding site [chemical binding]; other site 357348017170 AAA ATPase domain; Region: AAA_16; pfam13191 357348017171 AAA domain; Region: AAA_22; pfam13401 357348017172 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 357348017173 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 357348017174 DNA binding residues [nucleotide binding] 357348017175 dimerization interface [polypeptide binding]; other site 357348017176 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 357348017177 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 357348017178 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 357348017179 NADP binding site [chemical binding]; other site 357348017180 dimer interface [polypeptide binding]; other site 357348017181 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 357348017182 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 357348017183 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 357348017184 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 357348017185 D-galactonate transporter; Region: 2A0114; TIGR00893 357348017186 putative substrate translocation pore; other site 357348017187 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 357348017188 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 357348017189 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 357348017190 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 357348017191 catalytic residues [active] 357348017192 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 357348017193 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 357348017194 molybdopterin cofactor binding site; other site 357348017195 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 357348017196 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 357348017197 The MopB_CT_2 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is...; Region: MopB_CT_2; cd02783 357348017198 putative molybdopterin cofactor binding site; other site 357348017199 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 357348017200 4Fe-4S binding domain; Region: Fer4; pfam00037 357348017201 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 357348017202 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 357348017203 putative active site [active] 357348017204 putative metal binding site [ion binding]; other site 357348017205 Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200 357348017206 Transglycosylase; Region: Transgly; pfam00912 357348017207 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 357348017208 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 357348017209 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 357348017210 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 357348017211 catalytic residues [active] 357348017212 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 357348017213 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 357348017214 trimer interface [polypeptide binding]; other site 357348017215 eyelet of channel; other site 357348017216 amidase; Provisional; Region: PRK08137 357348017217 Amidase; Region: Amidase; cl11426 357348017218 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 357348017219 putative acetyltransferase YhhY; Provisional; Region: PRK10140 357348017220 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357348017221 Coenzyme A binding pocket [chemical binding]; other site 357348017222 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 357348017223 putative acetyltransferase YhhY; Provisional; Region: PRK10140 357348017224 Coenzyme A binding pocket [chemical binding]; other site 357348017225 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 357348017226 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 357348017227 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 357348017228 D-loop; other site 357348017229 H-loop/switch region; other site 357348017230 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 357348017231 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 357348017232 Histidine kinase; Region: HisKA_3; pfam07730 357348017233 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 357348017234 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 357348017235 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348017236 active site 357348017237 phosphorylation site [posttranslational modification] 357348017238 intermolecular recognition site; other site 357348017239 dimerization interface [polypeptide binding]; other site 357348017240 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 357348017241 DNA binding residues [nucleotide binding] 357348017242 dimerization interface [polypeptide binding]; other site 357348017243 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 357348017244 Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C [Coenzyme metabolism]; Region: COG5424 357348017245 PAS domain; Region: PAS_9; pfam13426 357348017246 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 357348017247 putative active site [active] 357348017248 heme pocket [chemical binding]; other site 357348017249 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 357348017250 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 357348017251 metal binding site [ion binding]; metal-binding site 357348017252 active site 357348017253 I-site; other site 357348017254 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 357348017255 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 357348017256 Lipase (class 2); Region: Lipase_2; pfam01674 357348017257 PGAP1-like protein; Region: PGAP1; pfam07819 357348017258 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 357348017259 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 357348017260 Domain of unknown function (DUF4345); Region: DUF4345; pfam14248 357348017261 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 357348017262 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 357348017263 FtsX-like permease family; Region: FtsX; pfam02687 357348017264 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 357348017265 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 357348017266 Walker A/P-loop; other site 357348017267 ATP binding site [chemical binding]; other site 357348017268 Q-loop/lid; other site 357348017269 ABC transporter signature motif; other site 357348017270 Walker B; other site 357348017271 D-loop; other site 357348017272 H-loop/switch region; other site 357348017273 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 357348017274 Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743 357348017275 Cytochrome P450; Region: p450; cl12078 357348017276 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 357348017277 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 357348017278 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 357348017279 putative NADP binding site [chemical binding]; other site 357348017280 active site 357348017281 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 357348017282 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 357348017283 putative NAD(P) binding site [chemical binding]; other site 357348017284 active site 357348017285 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 357348017286 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 357348017287 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 357348017288 active site 357348017289 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 357348017290 active site 357348017291 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 357348017292 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 357348017293 putative NADP binding site [chemical binding]; other site 357348017294 active site 357348017295 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 357348017296 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 357348017297 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 357348017298 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 357348017299 VacJ like lipoprotein; Region: VacJ; cl01073 357348017300 hypothetical protein; Provisional; Region: PRK07483 357348017301 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 357348017302 inhibitor-cofactor binding pocket; inhibition site 357348017303 pyridoxal 5'-phosphate binding site [chemical binding]; other site 357348017304 catalytic residue [active] 357348017305 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 357348017306 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 357348017307 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 357348017308 Walker A/P-loop; other site 357348017309 ATP binding site [chemical binding]; other site 357348017310 Q-loop/lid; other site 357348017311 ABC transporter signature motif; other site 357348017312 Walker B; other site 357348017313 D-loop; other site 357348017314 H-loop/switch region; other site 357348017315 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 357348017316 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 357348017317 dimer interface [polypeptide binding]; other site 357348017318 conserved gate region; other site 357348017319 putative PBP binding loops; other site 357348017320 ABC-ATPase subunit interface; other site 357348017321 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 357348017322 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 357348017323 substrate binding pocket [chemical binding]; other site 357348017324 membrane-bound complex binding site; other site 357348017325 hinge residues; other site 357348017326 hypothetical protein; Provisional; Region: PRK07077 357348017327 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 357348017328 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 357348017329 Active site cavity [active] 357348017330 catalytic acid [active] 357348017331 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 357348017332 active site lid residues [active] 357348017333 substrate binding pocket [chemical binding]; other site 357348017334 catalytic residues [active] 357348017335 substrate-Mg2+ binding site; other site 357348017336 aspartate-rich region 1; other site 357348017337 aspartate-rich region 2; other site 357348017338 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 357348017339 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 357348017340 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 357348017341 PAS fold; Region: PAS_4; pfam08448 357348017342 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 357348017343 putative active site [active] 357348017344 heme pocket [chemical binding]; other site 357348017345 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 357348017346 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 357348017347 metal binding site [ion binding]; metal-binding site 357348017348 active site 357348017349 I-site; other site 357348017350 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348017351 Response regulator receiver domain; Region: Response_reg; pfam00072 357348017352 active site 357348017353 phosphorylation site [posttranslational modification] 357348017354 intermolecular recognition site; other site 357348017355 dimerization interface [polypeptide binding]; other site 357348017356 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 357348017357 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 357348017358 dimer interface [polypeptide binding]; other site 357348017359 phosphorylation site [posttranslational modification] 357348017360 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 357348017361 ATP binding site [chemical binding]; other site 357348017362 Mg2+ binding site [ion binding]; other site 357348017363 G-X-G motif; other site 357348017364 Response regulator receiver domain; Region: Response_reg; pfam00072 357348017365 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 357348017366 active site 357348017367 phosphorylation site [posttranslational modification] 357348017368 intermolecular recognition site; other site 357348017369 dimerization interface [polypeptide binding]; other site 357348017370 Predicted flavoprotein [General function prediction only]; Region: COG0431 357348017371 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 357348017372 RNA polymerase sigma factor; Provisional; Region: PRK12545 357348017373 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 357348017374 DNA binding residues [nucleotide binding] 357348017375 Putative zinc-finger; Region: zf-HC2; pfam13490 357348017376 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 357348017377 ArsC family; Region: ArsC; pfam03960 357348017378 catalytic residues [active] 357348017379 ParA-like protein; Provisional; Region: PHA02518 357348017380 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 357348017381 P-loop; other site 357348017382 Magnesium ion binding site [ion binding]; other site 357348017383 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 357348017384 ParB-like nuclease domain; Region: ParB; smart00470 357348017385 Initiator Replication protein; Region: Rep_3; pfam01051