-- dump date 20140619_014431 -- class Genbank::misc_feature -- table misc_feature_note -- id note 398527000001 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 398527000002 Catalytic domain of Protein Kinases; Region: PKc; cd00180 398527000003 active site 398527000004 ATP binding site [chemical binding]; other site 398527000005 substrate binding site [chemical binding]; other site 398527000006 activation loop (A-loop); other site 398527000007 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 398527000008 Caspase domain; Region: Peptidase_C14; pfam00656 398527000009 Uncharacterized conserved protein [Function unknown]; Region: COG1262 398527000010 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 398527000011 Domain of unknown function (DUF4399); Region: DUF4399; pfam14347 398527000012 Domain of unknown function (DUF4399); Region: DUF4399; pfam14347 398527000013 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 398527000014 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 398527000015 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 398527000016 phosphopeptide binding site; other site 398527000017 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 398527000018 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 398527000019 phosphopeptide binding site; other site 398527000020 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 398527000021 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 398527000022 HlyD family secretion protein; Region: HlyD_3; pfam13437 398527000023 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 398527000024 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 398527000025 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 398527000026 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 398527000027 ligand binding site [chemical binding]; other site 398527000028 flexible hinge region; other site 398527000029 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 398527000030 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 398527000031 ligand binding site [chemical binding]; other site 398527000032 flexible hinge region; other site 398527000033 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 398527000034 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 398527000035 putative active site [active] 398527000036 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 398527000037 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 398527000038 Walker A/P-loop; other site 398527000039 ATP binding site [chemical binding]; other site 398527000040 Q-loop/lid; other site 398527000041 ABC transporter signature motif; other site 398527000042 Walker B; other site 398527000043 D-loop; other site 398527000044 H-loop/switch region; other site 398527000045 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 398527000046 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527000047 Walker A motif; other site 398527000048 ATP binding site [chemical binding]; other site 398527000049 Walker B motif; other site 398527000050 arginine finger; other site 398527000051 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 398527000052 active site 398527000053 Protein phosphatase 2C; Region: PP2C; pfam00481 398527000054 Lecithin retinol acyltransferase; Region: LRAT; pfam04970 398527000055 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 398527000056 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527000057 The C-terminal substrate-binding domain of LysR-type trnascriptional regulator BlaA which involved in control of the beta-lactamase gene expression; contains the type 2 periplasmic binding fold; Region: PBP2_BlaA; cd08487 398527000058 putative dimerization interface [polypeptide binding]; other site 398527000059 putative substrate binding pocket [chemical binding]; other site 398527000060 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 398527000061 Predicted membrane protein [Function unknown]; Region: COG3918 398527000062 potassium-tellurite ethidium and proflavin transporter; Provisional; Region: PRK10764 398527000063 gating phenylalanine in ion channel; other site 398527000064 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 398527000065 Transcriptional regulator [Transcription]; Region: IclR; COG1414 398527000066 Bacterial transcriptional regulator; Region: IclR; pfam01614 398527000067 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 398527000068 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 398527000069 active site 398527000070 citrylCoA binding site [chemical binding]; other site 398527000071 oxalacetate binding site [chemical binding]; other site 398527000072 coenzyme A binding site [chemical binding]; other site 398527000073 catalytic triad [active] 398527000074 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 398527000075 CoA-transferase family III; Region: CoA_transf_3; pfam02515 398527000076 benzoate transport; Region: 2A0115; TIGR00895 398527000077 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527000078 putative substrate translocation pore; other site 398527000079 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527000080 putative substrate translocation pore; other site 398527000081 Response regulator receiver domain; Region: Response_reg; pfam00072 398527000082 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527000083 active site 398527000084 phosphorylation site [posttranslational modification] 398527000085 intermolecular recognition site; other site 398527000086 dimerization interface [polypeptide binding]; other site 398527000087 circadian clock protein KaiC; Reviewed; Region: PRK09302 398527000088 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 398527000089 ATP binding site [chemical binding]; other site 398527000090 Walker A motif; other site 398527000091 Walker B motif; other site 398527000092 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 398527000093 Walker A motif; other site 398527000094 ATP binding site [chemical binding]; other site 398527000095 Walker B motif; other site 398527000096 Tannase and feruloyl esterase; Region: Tannase; pfam07519 398527000097 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 398527000098 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 398527000099 eyelet of channel; other site 398527000100 trimer interface [polypeptide binding]; other site 398527000101 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 398527000102 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527000103 putative substrate translocation pore; other site 398527000104 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 398527000105 MarR family; Region: MarR_2; pfam12802 398527000106 p-hydroxycinnamoyl CoA hydratase/lyase; Validated; Region: PRK09120 398527000107 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 398527000108 substrate binding site [chemical binding]; other site 398527000109 oxyanion hole (OAH) forming residues; other site 398527000110 trimer interface [polypeptide binding]; other site 398527000111 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 398527000112 Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105 398527000113 NAD(P) binding site [chemical binding]; other site 398527000114 catalytic residues [active] 398527000115 feruloyl-CoA synthase; Reviewed; Region: PRK08180 398527000116 Feruloyl-CoA synthetase (FCS); Region: FCS; cd05921 398527000117 acyl-activating enzyme (AAE) consensus motif; other site 398527000118 putative AMP binding site [chemical binding]; other site 398527000119 putative active site [active] 398527000120 putative CoA binding site [chemical binding]; other site 398527000121 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 398527000122 active site 398527000123 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 398527000124 active site lid residues [active] 398527000125 substrate binding pocket [chemical binding]; other site 398527000126 catalytic residues [active] 398527000127 substrate-Mg2+ binding site; other site 398527000128 aspartate-rich region 1; other site 398527000129 aspartate-rich region 2; other site 398527000130 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 398527000131 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 398527000132 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 398527000133 Tetratricopeptide repeat; Region: TPR_12; pfam13424 398527000134 TPR repeat; Region: TPR_11; pfam13414 398527000135 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 398527000136 binding surface 398527000137 TPR motif; other site 398527000138 Tetratricopeptide repeat; Region: TPR_16; pfam13432 398527000139 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 398527000140 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527000141 dimer interface [polypeptide binding]; other site 398527000142 conserved gate region; other site 398527000143 putative PBP binding loops; other site 398527000144 ABC-ATPase subunit interface; other site 398527000145 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 398527000146 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 398527000147 Walker A/P-loop; other site 398527000148 ATP binding site [chemical binding]; other site 398527000149 Q-loop/lid; other site 398527000150 ABC transporter signature motif; other site 398527000151 Walker B; other site 398527000152 D-loop; other site 398527000153 H-loop/switch region; other site 398527000154 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 398527000155 NMT1/THI5 like; Region: NMT1; pfam09084 398527000156 membrane-bound complex binding site; other site 398527000157 hinge residues; other site 398527000158 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 398527000159 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527000160 active site 398527000161 phosphorylation site [posttranslational modification] 398527000162 intermolecular recognition site; other site 398527000163 dimerization interface [polypeptide binding]; other site 398527000164 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 398527000165 DNA binding site [nucleotide binding] 398527000166 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 398527000167 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 398527000168 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 398527000169 dimer interface [polypeptide binding]; other site 398527000170 phosphorylation site [posttranslational modification] 398527000171 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527000172 ATP binding site [chemical binding]; other site 398527000173 Mg2+ binding site [ion binding]; other site 398527000174 G-X-G motif; other site 398527000175 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 398527000176 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 398527000177 membrane-bound complex binding site; other site 398527000178 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 398527000179 sensor protein QseC; Provisional; Region: PRK10337 398527000180 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 398527000181 dimer interface [polypeptide binding]; other site 398527000182 phosphorylation site [posttranslational modification] 398527000183 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527000184 ATP binding site [chemical binding]; other site 398527000185 Mg2+ binding site [ion binding]; other site 398527000186 G-X-G motif; other site 398527000187 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 398527000188 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527000189 active site 398527000190 phosphorylation site [posttranslational modification] 398527000191 intermolecular recognition site; other site 398527000192 dimerization interface [polypeptide binding]; other site 398527000193 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 398527000194 DNA binding site [nucleotide binding] 398527000195 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 398527000196 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 398527000197 trimer interface [polypeptide binding]; other site 398527000198 eyelet of channel; other site 398527000199 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 398527000200 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 398527000201 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 398527000202 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 398527000203 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 398527000204 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 398527000205 putative ADP-binding pocket [chemical binding]; other site 398527000206 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 398527000207 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 398527000208 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 398527000209 tyrosine kinase; Provisional; Region: PRK11519 398527000210 Chain length determinant protein; Region: Wzz; pfam02706 398527000211 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 398527000212 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 398527000213 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 398527000214 Low molecular weight phosphatase family; Region: LMWPc; cd00115 398527000215 active site 398527000216 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 398527000217 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 398527000218 SLBB domain; Region: SLBB; pfam10531 398527000219 SLBB domain; Region: SLBB; pfam10531 398527000220 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 398527000221 Bacterial sugar transferase; Region: Bac_transf; pfam02397 398527000222 Phospholipid methyltransferase; Region: PEMT; cl17370 398527000223 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 398527000224 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 398527000225 putative active site [active] 398527000226 metal binding site [ion binding]; metal-binding site 398527000227 Uncharacterized conserved protein [Function unknown]; Region: COG1359 398527000228 extracytoplasmic-function sigma-70 factor; Validated; Region: PRK07037 398527000229 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 398527000230 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 398527000231 DNA binding residues [nucleotide binding] 398527000232 MbtH-like protein; Region: MbtH; cl01279 398527000233 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 398527000234 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 398527000235 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 398527000236 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 398527000237 Walker A/P-loop; other site 398527000238 ATP binding site [chemical binding]; other site 398527000239 Q-loop/lid; other site 398527000240 ABC transporter signature motif; other site 398527000241 Walker B; other site 398527000242 D-loop; other site 398527000243 H-loop/switch region; other site 398527000244 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 398527000245 FecCD transport family; Region: FecCD; pfam01032 398527000246 ABC-ATPase subunit interface; other site 398527000247 dimer interface [polypeptide binding]; other site 398527000248 putative PBP binding regions; other site 398527000249 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 398527000250 ABC-ATPase subunit interface; other site 398527000251 dimer interface [polypeptide binding]; other site 398527000252 putative PBP binding regions; other site 398527000253 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 398527000254 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 398527000255 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 398527000256 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 398527000257 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 398527000258 siderophore binding site; other site 398527000259 cyclic peptide transporter; Region: cyc_pep_trnsptr; TIGR01194 398527000260 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 398527000261 Walker A/P-loop; other site 398527000262 ATP binding site [chemical binding]; other site 398527000263 Q-loop/lid; other site 398527000264 ABC transporter signature motif; other site 398527000265 Walker B; other site 398527000266 D-loop; other site 398527000267 H-loop/switch region; other site 398527000268 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 398527000269 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 398527000270 acyl-activating enzyme (AAE) consensus motif; other site 398527000271 AMP binding site [chemical binding]; other site 398527000272 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 398527000273 Condensation domain; Region: Condensation; pfam00668 398527000274 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 398527000275 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 398527000276 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 398527000277 acyl-activating enzyme (AAE) consensus motif; other site 398527000278 AMP binding site [chemical binding]; other site 398527000279 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 398527000280 Condensation domain; Region: Condensation; pfam00668 398527000281 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 398527000282 Condensation domain; Region: Condensation; pfam00668 398527000283 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 398527000284 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 398527000285 acyl-activating enzyme (AAE) consensus motif; other site 398527000286 AMP binding site [chemical binding]; other site 398527000287 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 398527000288 Condensation domain; Region: Condensation; pfam00668 398527000289 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 398527000290 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 398527000291 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 398527000292 acyl-activating enzyme (AAE) consensus motif; other site 398527000293 AMP binding site [chemical binding]; other site 398527000294 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 398527000295 Condensation domain; Region: Condensation; pfam00668 398527000296 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 398527000297 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 398527000298 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 398527000299 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 398527000300 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 398527000301 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 398527000302 N-terminal plug; other site 398527000303 ligand-binding site [chemical binding]; other site 398527000304 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 398527000305 catalytic site [active] 398527000306 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527000307 putative substrate translocation pore; other site 398527000308 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527000309 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527000310 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 398527000311 putative effector binding pocket; other site 398527000312 putative dimerization interface [polypeptide binding]; other site 398527000313 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 398527000314 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 398527000315 N-terminal plug; other site 398527000316 ligand-binding site [chemical binding]; other site 398527000317 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 398527000318 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 398527000319 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 398527000320 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 398527000321 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527000322 D-galactonate transporter; Region: 2A0114; TIGR00893 398527000323 putative substrate translocation pore; other site 398527000324 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 398527000325 CoA binding domain; Region: CoA_binding_2; pfam13380 398527000326 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 398527000327 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 398527000328 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 398527000329 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 398527000330 active site 398527000331 Transcriptional regulator [Transcription]; Region: IclR; COG1414 398527000332 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 398527000333 Protein of unknown function (DUF3443); Region: DUF3443; pfam11925 398527000334 Protein of unknown function (DUF2844); Region: DUF2844; pfam11005 398527000335 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527000336 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527000337 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 398527000338 putative dimerization interface [polypeptide binding]; other site 398527000339 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 398527000340 Citrate transporter; Region: CitMHS; pfam03600 398527000341 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 398527000342 LysR family transcriptional regulator; Provisional; Region: PRK14997 398527000343 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527000344 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 398527000345 putative effector binding pocket; other site 398527000346 dimerization interface [polypeptide binding]; other site 398527000347 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 398527000348 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527000349 putative substrate translocation pore; other site 398527000350 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 398527000351 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 398527000352 FMN binding site [chemical binding]; other site 398527000353 active site 398527000354 substrate binding site [chemical binding]; other site 398527000355 catalytic residue [active] 398527000356 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527000357 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527000358 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 398527000359 putative effector binding pocket; other site 398527000360 putative dimerization interface [polypeptide binding]; other site 398527000361 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 398527000362 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 398527000363 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 398527000364 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 398527000365 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 398527000366 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 398527000367 NAD(P) binding site [chemical binding]; other site 398527000368 active site 398527000369 Transcriptional regulators [Transcription]; Region: FadR; COG2186 398527000370 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527000371 DNA-binding site [nucleotide binding]; DNA binding site 398527000372 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 398527000373 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527000374 D-galactonate transporter; Region: 2A0114; TIGR00893 398527000375 putative substrate translocation pore; other site 398527000376 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 398527000377 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 398527000378 active site 398527000379 tetramer interface [polypeptide binding]; other site 398527000380 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 398527000381 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 398527000382 putative active site [active] 398527000383 catalytic residue [active] 398527000384 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527000385 Major Facilitator Superfamily; Region: MFS_1; pfam07690 398527000386 putative substrate translocation pore; other site 398527000387 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527000388 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 398527000389 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 398527000390 Dehydroquinase class II; Region: DHquinase_II; pfam01220 398527000391 trimer interface [polypeptide binding]; other site 398527000392 active site 398527000393 dimer interface [polypeptide binding]; other site 398527000394 metabolite-proton symporter; Region: 2A0106; TIGR00883 398527000395 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527000396 putative substrate translocation pore; other site 398527000397 Transcriptional regulator [Transcription]; Region: IclR; COG1414 398527000398 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 398527000399 Bacterial transcriptional regulator; Region: IclR; pfam01614 398527000400 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 398527000401 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 398527000402 NAD(P) binding site [chemical binding]; other site 398527000403 active site 398527000404 Hydroxyquinol 1,2-dioxygenase (1,2-HQD) catalyzes the ring cleavage of hydroxyquinol (1,2,4-trihydroxybenzene), a intermediate in the degradation of a large variety of aromatic compounds including some polychloro- and nitroaromatic pollutants, to form...; Region: 1,2-HQD; cd03461 398527000405 chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465 398527000406 dimer interface [polypeptide binding]; other site 398527000407 active site 398527000408 NmrA-like family; Region: NmrA; pfam05368 398527000409 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 398527000410 NADP binding site [chemical binding]; other site 398527000411 active site 398527000412 regulatory binding site [polypeptide binding]; other site 398527000413 LysR family transcriptional regulator; Provisional; Region: PRK14997 398527000414 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527000415 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 398527000416 putative effector binding pocket; other site 398527000417 dimerization interface [polypeptide binding]; other site 398527000418 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 398527000419 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 398527000420 Cache domain; Region: Cache_2; pfam08269 398527000421 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 398527000422 dimer interface [polypeptide binding]; other site 398527000423 putative CheW interface [polypeptide binding]; other site 398527000424 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 398527000425 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 398527000426 eyelet of channel; other site 398527000427 trimer interface [polypeptide binding]; other site 398527000428 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 398527000429 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 398527000430 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 398527000431 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 398527000432 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 398527000433 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 398527000434 NAD(P) binding site [chemical binding]; other site 398527000435 active site 398527000436 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 398527000437 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 398527000438 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 398527000439 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 398527000440 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527000441 The C-terminal substrate binding domain of LysR-type transcriptional regulator HcaR in involved in 3-phenylpropionic acid catabolism, contains the type2 periplasmic binding fold; Region: PBP2_HcaR; cd08450 398527000442 putative dimerization interface [polypeptide binding]; other site 398527000443 putative substrate binding pocket [chemical binding]; other site 398527000444 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 398527000445 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 398527000446 active site 398527000447 allantoate amidohydrolase; Reviewed; Region: PRK12893 398527000448 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 398527000449 active site 398527000450 metal binding site [ion binding]; metal-binding site 398527000451 dimer interface [polypeptide binding]; other site 398527000452 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 398527000453 Coenzyme A binding pocket [chemical binding]; other site 398527000454 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 398527000455 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 398527000456 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 398527000457 DNA binding site [nucleotide binding] 398527000458 active site 398527000459 Leucine rich repeat; Region: LRR_8; pfam13855 398527000460 Tyrosine kinase, catalytic domain; Region: TyrKc; smart00219 398527000461 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 398527000462 active site 398527000463 ATP binding site [chemical binding]; other site 398527000464 substrate binding site [chemical binding]; other site 398527000465 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 398527000466 activation loop (A-loop); other site 398527000467 activation loop (A-loop); other site 398527000468 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 398527000469 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 398527000470 ligand binding site [chemical binding]; other site 398527000471 PRC-barrel domain; Region: PRC; pfam05239 398527000472 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 398527000473 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 398527000474 putative active site [active] 398527000475 Predicted ester cyclase [General function prediction only]; Region: COG5485 398527000476 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 398527000477 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 398527000478 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 398527000479 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 398527000480 putative Zn2+ binding site [ion binding]; other site 398527000481 putative DNA binding site [nucleotide binding]; other site 398527000482 methionine sulfoxide reductase A; Provisional; Region: PRK14054 398527000483 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 398527000484 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 398527000485 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527000486 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527000487 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 398527000488 putative effector binding pocket; other site 398527000489 dimerization interface [polypeptide binding]; other site 398527000490 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 398527000491 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 398527000492 FMN binding site [chemical binding]; other site 398527000493 substrate binding site [chemical binding]; other site 398527000494 putative catalytic residue [active] 398527000495 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 398527000496 active site 1 [active] 398527000497 dimer interface [polypeptide binding]; other site 398527000498 hexamer interface [polypeptide binding]; other site 398527000499 active site 2 [active] 398527000500 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 398527000501 classical (c) SDRs; Region: SDR_c; cd05233 398527000502 NAD(P) binding site [chemical binding]; other site 398527000503 active site 398527000504 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 398527000505 active site 398527000506 nucleophile elbow; other site 398527000507 Patatin phospholipase; Region: DUF3734; pfam12536 398527000508 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 398527000509 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 398527000510 HlyD family secretion protein; Region: HlyD_3; pfam13437 398527000511 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 398527000512 ligand binding site [chemical binding]; other site 398527000513 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 398527000514 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 398527000515 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 398527000516 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 398527000517 tetramer interface [polypeptide binding]; other site 398527000518 active site 398527000519 Mg2+/Mn2+ binding site [ion binding]; other site 398527000520 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 398527000521 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527000522 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 398527000523 dimerization interface [polypeptide binding]; other site 398527000524 substrate binding pocket [chemical binding]; other site 398527000525 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 398527000526 Predicted amidohydrolase [General function prediction only]; Region: COG0388 398527000527 active site 398527000528 catalytic triad [active] 398527000529 dimer interface [polypeptide binding]; other site 398527000530 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527000531 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527000532 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 398527000533 dimerization interface [polypeptide binding]; other site 398527000534 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 398527000535 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 398527000536 ligand binding site [chemical binding]; other site 398527000537 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 398527000538 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 398527000539 Walker A/P-loop; other site 398527000540 ATP binding site [chemical binding]; other site 398527000541 Q-loop/lid; other site 398527000542 ABC transporter signature motif; other site 398527000543 Walker B; other site 398527000544 D-loop; other site 398527000545 H-loop/switch region; other site 398527000546 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 398527000547 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 398527000548 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 398527000549 TM-ABC transporter signature motif; other site 398527000550 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 398527000551 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 398527000552 substrate binding site [chemical binding]; other site 398527000553 dimer interface [polypeptide binding]; other site 398527000554 ATP binding site [chemical binding]; other site 398527000555 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 398527000556 active site 398527000557 CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080 398527000558 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 398527000559 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 398527000560 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 398527000561 dimer interface [polypeptide binding]; other site 398527000562 phosphorylation site [posttranslational modification] 398527000563 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527000564 ATP binding site [chemical binding]; other site 398527000565 Mg2+ binding site [ion binding]; other site 398527000566 G-X-G motif; other site 398527000567 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 398527000568 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 398527000569 WHG domain; Region: WHG; pfam13305 398527000570 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 398527000571 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 398527000572 Walker A/P-loop; other site 398527000573 ATP binding site [chemical binding]; other site 398527000574 Q-loop/lid; other site 398527000575 ABC transporter signature motif; other site 398527000576 Walker B; other site 398527000577 D-loop; other site 398527000578 H-loop/switch region; other site 398527000579 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 398527000580 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 398527000581 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 398527000582 TM-ABC transporter signature motif; other site 398527000583 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 398527000584 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 398527000585 putative ligand binding site [chemical binding]; other site 398527000586 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 398527000587 Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324 398527000588 putative active site pocket [active] 398527000589 metal binding site [ion binding]; metal-binding site 398527000590 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 398527000591 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 398527000592 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 398527000593 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 398527000594 Protein of unknown function (DUF993); Region: DUF993; pfam06187 398527000595 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 398527000596 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 398527000597 NAD(P) binding site [chemical binding]; other site 398527000598 active site 398527000599 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 398527000600 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 398527000601 active site 398527000602 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 398527000603 Coenzyme A transferase; Region: CoA_trans; smart00882 398527000604 Coenzyme A transferase; Region: CoA_trans; cl17247 398527000605 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 398527000606 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 398527000607 Gluconobacter oxydans L-sorbosone dehydrogenase-like; Region: ALDH_SNDH; cd07118 398527000608 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 398527000609 NAD(P) binding site [chemical binding]; other site 398527000610 catalytic residues [active] 398527000611 choline dehydrogenase; Validated; Region: PRK02106 398527000612 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 398527000613 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 398527000614 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 398527000615 ligand binding site [chemical binding]; other site 398527000616 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 398527000617 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 398527000618 TM-ABC transporter signature motif; other site 398527000619 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 398527000620 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 398527000621 Walker A/P-loop; other site 398527000622 ATP binding site [chemical binding]; other site 398527000623 Q-loop/lid; other site 398527000624 ABC transporter signature motif; other site 398527000625 Walker B; other site 398527000626 D-loop; other site 398527000627 H-loop/switch region; other site 398527000628 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 398527000629 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 398527000630 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 398527000631 TM-ABC transporter signature motif; other site 398527000632 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 398527000633 Ligand binding site [chemical binding]; other site 398527000634 Electron transfer flavoprotein domain; Region: ETF; pfam01012 398527000635 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 398527000636 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 398527000637 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 398527000638 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 398527000639 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 398527000640 active site 398527000641 catalytic tetrad [active] 398527000642 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 398527000643 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 398527000644 active site residue [active] 398527000645 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 398527000646 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 398527000647 dimer interface [polypeptide binding]; other site 398527000648 decamer (pentamer of dimers) interface [polypeptide binding]; other site 398527000649 catalytic triad [active] 398527000650 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 398527000651 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 398527000652 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527000653 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 398527000654 dimerization interface [polypeptide binding]; other site 398527000655 substrate binding pocket [chemical binding]; other site 398527000656 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 398527000657 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 398527000658 dimerization interface [polypeptide binding]; other site 398527000659 NAD binding site [chemical binding]; other site 398527000660 ligand binding site [chemical binding]; other site 398527000661 catalytic site [active] 398527000662 Isochorismatase family; Region: Isochorismatase; pfam00857 398527000663 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 398527000664 catalytic triad [active] 398527000665 conserved cis-peptide bond; other site 398527000666 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 398527000667 hydrophobic ligand binding site; other site 398527000668 SET domain; Region: SET; pfam00856 398527000669 Predicted membrane protein [Function unknown]; Region: COG2261 398527000670 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 398527000671 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 398527000672 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 398527000673 Walker A/P-loop; other site 398527000674 ATP binding site [chemical binding]; other site 398527000675 Q-loop/lid; other site 398527000676 ABC transporter signature motif; other site 398527000677 Walker B; other site 398527000678 D-loop; other site 398527000679 H-loop/switch region; other site 398527000680 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 398527000681 Lipocalin-like domain; Region: Lipocalin_5; pfam13924 398527000682 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 398527000683 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 398527000684 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 398527000685 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 398527000686 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 398527000687 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 398527000688 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 398527000689 catalytic loop [active] 398527000690 iron binding site [ion binding]; other site 398527000691 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 398527000692 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 398527000693 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 398527000694 potential catalytic triad [active] 398527000695 conserved cys residue [active] 398527000696 Protein of unknown function (DUF1330); Region: DUF1330; pfam07045 398527000697 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 398527000698 Helix-turn-helix domain; Region: HTH_17; pfam12728 398527000699 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102 398527000700 active site 398527000701 coenzyme A binding site [chemical binding]; other site 398527000702 citrylCoA binding site [chemical binding]; other site 398527000703 dimer interface [polypeptide binding]; other site 398527000704 Citrate synthase; Region: Citrate_synt; pfam00285 398527000705 oxalacetate/citrate binding site [chemical binding]; other site 398527000706 catalytic triad [active] 398527000707 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 398527000708 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 398527000709 active site 398527000710 metal binding site [ion binding]; metal-binding site 398527000711 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527000712 D-galactonate transporter; Region: 2A0114; TIGR00893 398527000713 putative substrate translocation pore; other site 398527000714 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 398527000715 classical (c) SDRs; Region: SDR_c; cd05233 398527000716 NAD(P) binding site [chemical binding]; other site 398527000717 active site 398527000718 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 398527000719 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 398527000720 dimerization interface [polypeptide binding]; other site 398527000721 ligand binding site [chemical binding]; other site 398527000722 NADP binding site [chemical binding]; other site 398527000723 catalytic site [active] 398527000724 PRC-barrel domain; Region: PRC; pfam05239 398527000725 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 398527000726 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 398527000727 motif II; other site 398527000728 H-NS histone family; Region: Histone_HNS; pfam00816 398527000729 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 398527000730 Phasin protein; Region: Phasin_2; pfam09361 398527000731 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 398527000732 nudix motif; other site 398527000733 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 398527000734 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 398527000735 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 398527000736 active site 398527000737 homodimer interface [polypeptide binding]; other site 398527000738 homotetramer interface [polypeptide binding]; other site 398527000739 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 398527000740 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 398527000741 hydroxyglutarate oxidase; Provisional; Region: PRK11728 398527000742 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 398527000743 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 398527000744 conserved cys residue [active] 398527000745 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527000746 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 398527000747 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 398527000748 dimerization interface [polypeptide binding]; other site 398527000749 ligand binding site [chemical binding]; other site 398527000750 Hemerythrin-like domain; Region: Hr-like; cd12108 398527000751 Fe binding site [ion binding]; other site 398527000752 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 398527000753 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 398527000754 Walker A/P-loop; other site 398527000755 ATP binding site [chemical binding]; other site 398527000756 Q-loop/lid; other site 398527000757 ABC transporter signature motif; other site 398527000758 Walker B; other site 398527000759 D-loop; other site 398527000760 H-loop/switch region; other site 398527000761 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 398527000762 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 398527000763 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 398527000764 TM-ABC transporter signature motif; other site 398527000765 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 398527000766 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 398527000767 TM-ABC transporter signature motif; other site 398527000768 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 398527000769 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 398527000770 putative ligand binding site [chemical binding]; other site 398527000771 glutathione-dependent formaldehyde-activating enzyme; Provisional; Region: PRK05417 398527000772 S-formylglutathione hydrolase; Region: PLN02442 398527000773 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 398527000774 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527000775 DNA-binding site [nucleotide binding]; DNA binding site 398527000776 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 398527000777 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 398527000778 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527000779 homodimer interface [polypeptide binding]; other site 398527000780 catalytic residue [active] 398527000781 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 398527000782 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 398527000783 active site 398527000784 metal binding site [ion binding]; metal-binding site 398527000785 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 398527000786 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 398527000787 FMN-binding pocket [chemical binding]; other site 398527000788 flavin binding motif; other site 398527000789 phosphate binding motif [ion binding]; other site 398527000790 beta-alpha-beta structure motif; other site 398527000791 NAD binding pocket [chemical binding]; other site 398527000792 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 398527000793 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 398527000794 catalytic loop [active] 398527000795 iron binding site [ion binding]; other site 398527000796 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 398527000797 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 398527000798 iron-sulfur cluster [ion binding]; other site 398527000799 [2Fe-2S] cluster binding site [ion binding]; other site 398527000800 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 398527000801 hydrophobic ligand binding site; other site 398527000802 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 398527000803 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 398527000804 [2Fe-2S] cluster binding site [ion binding]; other site 398527000805 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 398527000806 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 398527000807 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 398527000808 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 398527000809 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 398527000810 inhibitor-cofactor binding pocket; inhibition site 398527000811 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527000812 catalytic residue [active] 398527000813 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 398527000814 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 398527000815 tetrameric interface [polypeptide binding]; other site 398527000816 NAD binding site [chemical binding]; other site 398527000817 catalytic residues [active] 398527000818 phenylhydantoinase; Validated; Region: PRK08323 398527000819 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 398527000820 tetramer interface [polypeptide binding]; other site 398527000821 active site 398527000822 FO synthase subunit 1; Reviewed; Region: cofG; PRK06245 398527000823 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 398527000824 FeS/SAM binding site; other site 398527000825 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase, CofH subunit; Region: F420_cofH; TIGR03551 398527000826 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 398527000827 FeS/SAM binding site; other site 398527000828 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 398527000829 phosphate binding site [ion binding]; other site 398527000830 dimer interface [polypeptide binding]; other site 398527000831 substrate binding site [chemical binding]; other site 398527000832 2-phospho-L-lactate guanylyltransferase; Region: F420_cofC; TIGR03552 398527000833 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478 398527000834 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 398527000835 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 398527000836 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 398527000837 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 398527000838 F420-dependent oxidoreductase, CPS_4043 family; Region: F420_CPS_4043; TIGR03842 398527000839 allantoate amidohydrolase; Reviewed; Region: PRK12893 398527000840 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 398527000841 active site 398527000842 metal binding site [ion binding]; metal-binding site 398527000843 dimer interface [polypeptide binding]; other site 398527000844 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 398527000845 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 398527000846 ligand binding site [chemical binding]; other site 398527000847 homodimer interface [polypeptide binding]; other site 398527000848 NAD(P) binding site [chemical binding]; other site 398527000849 trimer interface B [polypeptide binding]; other site 398527000850 trimer interface A [polypeptide binding]; other site 398527000851 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 398527000852 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 398527000853 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 398527000854 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527000855 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527000856 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 398527000857 putative effector binding pocket; other site 398527000858 dimerization interface [polypeptide binding]; other site 398527000859 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 398527000860 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 398527000861 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 398527000862 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 398527000863 trimer interface [polypeptide binding]; other site 398527000864 eyelet of channel; other site 398527000865 Phosphoesterase family; Region: Phosphoesterase; pfam04185 398527000866 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 398527000867 BNR repeat-like domain; Region: BNR_2; pfam13088 398527000868 Protein of unknown function (DUF1007); Region: DUF1007; cl01487 398527000869 High-affinity nickel-transport protein; Region: NicO; cl00964 398527000870 5-histidylcysteine sulfoxide synthase; Region: ovoA_Nterm; TIGR04344 398527000871 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 398527000872 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 398527000873 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 398527000874 ligand binding site [chemical binding]; other site 398527000875 flexible hinge region; other site 398527000876 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 398527000877 putative switch regulator; other site 398527000878 non-specific DNA interactions [nucleotide binding]; other site 398527000879 DNA binding site [nucleotide binding] 398527000880 sequence specific DNA binding site [nucleotide binding]; other site 398527000881 putative cAMP binding site [chemical binding]; other site 398527000882 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 398527000883 Ligand Binding Site [chemical binding]; other site 398527000884 Transcriptional regulators [Transcription]; Region: FadR; COG2186 398527000885 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527000886 DNA-binding site [nucleotide binding]; DNA binding site 398527000887 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 398527000888 Autoinducer synthetase; Region: Autoind_synth; cl17404 398527000889 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 398527000890 non-specific DNA binding site [nucleotide binding]; other site 398527000891 salt bridge; other site 398527000892 sequence-specific DNA binding site [nucleotide binding]; other site 398527000893 Autoinducer binding domain; Region: Autoind_bind; pfam03472 398527000894 LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541 398527000895 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 398527000896 DNA binding residues [nucleotide binding] 398527000897 dimerization interface [polypeptide binding]; other site 398527000898 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 398527000899 Strictosidine synthase; Region: Str_synth; pfam03088 398527000900 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 398527000901 hypothetical protein; Provisional; Region: PRK11622 398527000902 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 398527000903 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 398527000904 Walker A/P-loop; other site 398527000905 ATP binding site [chemical binding]; other site 398527000906 Q-loop/lid; other site 398527000907 ABC transporter signature motif; other site 398527000908 Walker B; other site 398527000909 D-loop; other site 398527000910 H-loop/switch region; other site 398527000911 TOBE domain; Region: TOBE_2; pfam08402 398527000912 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527000913 dimer interface [polypeptide binding]; other site 398527000914 conserved gate region; other site 398527000915 putative PBP binding loops; other site 398527000916 ABC-ATPase subunit interface; other site 398527000917 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 398527000918 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527000919 dimer interface [polypeptide binding]; other site 398527000920 conserved gate region; other site 398527000921 putative PBP binding loops; other site 398527000922 ABC-ATPase subunit interface; other site 398527000923 dihydroxy-acid dehydratase; Validated; Region: PRK06131 398527000924 short chain dehydrogenase; Provisional; Region: PRK12827 398527000925 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 398527000926 putative NAD(P) binding site [chemical binding]; other site 398527000927 homodimer interface [polypeptide binding]; other site 398527000928 Protein of unknown function (DUF3005); Region: DUF3005; pfam11448 398527000929 serine O-acetyltransferase; Region: cysE; TIGR01172 398527000930 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 398527000931 trimer interface [polypeptide binding]; other site 398527000932 active site 398527000933 substrate binding site [chemical binding]; other site 398527000934 CoA binding site [chemical binding]; other site 398527000935 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 398527000936 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 398527000937 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527000938 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 398527000939 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 398527000940 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 398527000941 trimer interface [polypeptide binding]; other site 398527000942 eyelet of channel; other site 398527000943 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 398527000944 stationary phase growth adaptation protein; Provisional; Region: PRK09717 398527000945 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 398527000946 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 398527000947 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 398527000948 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 398527000949 active site 398527000950 metal-binding site 398527000951 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527000952 putative transporter; Provisional; Region: PRK10504 398527000953 putative substrate translocation pore; other site 398527000954 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527000955 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 398527000956 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 398527000957 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 398527000958 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 398527000959 protein binding site [polypeptide binding]; other site 398527000960 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 398527000961 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 398527000962 active site 398527000963 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 398527000964 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 398527000965 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 398527000966 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 398527000967 putative NAD(P) binding site [chemical binding]; other site 398527000968 homodimer interface [polypeptide binding]; other site 398527000969 CHAD domain; Region: CHAD; pfam05235 398527000970 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 398527000971 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 398527000972 active site residue [active] 398527000973 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 398527000974 EamA-like transporter family; Region: EamA; pfam00892 398527000975 EamA-like transporter family; Region: EamA; pfam00892 398527000976 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 398527000977 GTP cyclohydrolase I; Provisional; Region: PLN03044 398527000978 active site 398527000979 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527000980 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527000981 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 398527000982 substrate binding pocket [chemical binding]; other site 398527000983 dimerization interface [polypeptide binding]; other site 398527000984 3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429 398527000985 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 398527000986 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 398527000987 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 398527000988 tetramer interface [polypeptide binding]; other site 398527000989 active site 398527000990 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 398527000991 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 398527000992 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 398527000993 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 398527000994 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 398527000995 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 398527000996 Walker A/P-loop; other site 398527000997 ATP binding site [chemical binding]; other site 398527000998 Q-loop/lid; other site 398527000999 ABC transporter signature motif; other site 398527001000 Walker B; other site 398527001001 D-loop; other site 398527001002 H-loop/switch region; other site 398527001003 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 398527001004 putative carbohydrate binding site [chemical binding]; other site 398527001005 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 398527001006 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 398527001007 putative homodimer interface [polypeptide binding]; other site 398527001008 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 398527001009 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 398527001010 Methyltransferase domain; Region: Methyltransf_31; pfam13847 398527001011 S-adenosylmethionine binding site [chemical binding]; other site 398527001012 Methyltransferase domain; Region: Methyltransf_12; pfam08242 398527001013 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 398527001014 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 398527001015 active site 398527001016 homodimer interface [polypeptide binding]; other site 398527001017 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 398527001018 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 398527001019 hypothetical protein; Provisional; Region: PRK04334 398527001020 Amino acid synthesis; Region: AA_synth; pfam06684 398527001021 Amino acid synthesis; Region: AA_synth; pfam06684 398527001022 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 398527001023 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 398527001024 TM-ABC transporter signature motif; other site 398527001025 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 398527001026 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 398527001027 TM-ABC transporter signature motif; other site 398527001028 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 398527001029 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 398527001030 Walker A/P-loop; other site 398527001031 ATP binding site [chemical binding]; other site 398527001032 Q-loop/lid; other site 398527001033 ABC transporter signature motif; other site 398527001034 Walker B; other site 398527001035 D-loop; other site 398527001036 H-loop/switch region; other site 398527001037 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 398527001038 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 398527001039 Walker A/P-loop; other site 398527001040 ATP binding site [chemical binding]; other site 398527001041 Q-loop/lid; other site 398527001042 ABC transporter signature motif; other site 398527001043 Walker B; other site 398527001044 D-loop; other site 398527001045 H-loop/switch region; other site 398527001046 Amidohydrolase; Region: Amidohydro_5; pfam13594 398527001047 Amidohydrolase; Region: Amidohydro_4; pfam13147 398527001048 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 398527001049 active site 398527001050 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 398527001051 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 398527001052 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 398527001053 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 398527001054 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 398527001055 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 398527001056 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 398527001057 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 398527001058 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 398527001059 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 398527001060 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_Arsenic_SBP_like; cd06330 398527001061 putative ligand binding site [chemical binding]; other site 398527001062 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 398527001063 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 398527001064 DNA binding residues [nucleotide binding] 398527001065 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 398527001066 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 398527001067 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 398527001068 S-adenosylmethionine binding site [chemical binding]; other site 398527001069 beta alanine--pyruvate transaminase; Provisional; Region: PRK09221 398527001070 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 398527001071 inhibitor-cofactor binding pocket; inhibition site 398527001072 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527001073 catalytic residue [active] 398527001074 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 398527001075 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527001076 DNA-binding site [nucleotide binding]; DNA binding site 398527001077 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 398527001078 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527001079 homodimer interface [polypeptide binding]; other site 398527001080 catalytic residue [active] 398527001081 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 398527001082 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 398527001083 FAD binding pocket [chemical binding]; other site 398527001084 conserved FAD binding motif [chemical binding]; other site 398527001085 phosphate binding motif [ion binding]; other site 398527001086 beta-alpha-beta structure motif; other site 398527001087 NAD binding pocket [chemical binding]; other site 398527001088 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 398527001089 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 398527001090 NAD(P) binding site [chemical binding]; other site 398527001091 active site 398527001092 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 398527001093 NmrA (a transcriptional regulator) and triphenylmethane reductase (TMR) like proteins, subgroup 1, atypical (a) SDRs; Region: NmrA_TMR_like_1_SDR_a; cd05231 398527001094 putative NADP binding site [chemical binding]; other site 398527001095 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 398527001096 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 398527001097 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 398527001098 classical (c) SDRs; Region: SDR_c; cd05233 398527001099 NAD(P) binding site [chemical binding]; other site 398527001100 active site 398527001101 NADH(P)-binding; Region: NAD_binding_10; pfam13460 398527001102 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 398527001103 NAD(P) binding site [chemical binding]; other site 398527001104 active site 398527001105 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 398527001106 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527001107 DNA-binding site [nucleotide binding]; DNA binding site 398527001108 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 398527001109 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527001110 homodimer interface [polypeptide binding]; other site 398527001111 catalytic residue [active] 398527001112 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 398527001113 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 398527001114 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 398527001115 Coenzyme A binding pocket [chemical binding]; other site 398527001116 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527001117 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527001118 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 398527001119 putative effector binding pocket; other site 398527001120 dimerization interface [polypeptide binding]; other site 398527001121 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 398527001122 NmrA-like family; Region: NmrA; pfam05368 398527001123 NAD(P) binding site [chemical binding]; other site 398527001124 active site 398527001125 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 398527001126 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 398527001127 active site 398527001128 metal binding site [ion binding]; metal-binding site 398527001129 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 398527001130 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 398527001131 catalytic site [active] 398527001132 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527001133 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527001134 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 398527001135 dimerization interface [polypeptide binding]; other site 398527001136 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 398527001137 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 398527001138 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 398527001139 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 398527001140 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 398527001141 active site 398527001142 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 398527001143 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 398527001144 SnoaL-like domain; Region: SnoaL_2; pfam12680 398527001145 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 398527001146 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 398527001147 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 398527001148 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556 398527001149 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 398527001150 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 398527001151 cobaltochelatase, CobT subunit; Region: CobT; TIGR01651 398527001152 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 398527001153 metal ion-dependent adhesion site (MIDAS); other site 398527001154 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 398527001155 sulfoacetaldehyde acetyltransferase; Validated; Region: PRK07525 398527001156 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 398527001157 PYR/PP interface [polypeptide binding]; other site 398527001158 dimer interface [polypeptide binding]; other site 398527001159 TPP binding site [chemical binding]; other site 398527001160 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 398527001161 Thiamine pyrophosphate (TPP) family, Xsc-like subfamily, TPP-binding module; composed of proteins similar to Alcaligenes defragrans sulfoacetaldehyde acetyltransferase (Xsc). Xsc plays a key role in the degradation of taurine, catalyzing the...; Region: TPP_Xsc_like; cd02013 398527001162 TPP-binding site; other site 398527001163 putative phosphonoacetaldehyde dehydrogenase; Region: PhnAcAld_DH; TIGR03250 398527001164 Streptomyces putative phosphonoformaldehyde dehydrogenase PhpJ-like; Region: ALDH_PhpJ; cd07146 398527001165 NAD(P) binding site [chemical binding]; other site 398527001166 catalytic residues [active] 398527001167 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 398527001168 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527001169 ABC-ATPase subunit interface; other site 398527001170 putative PBP binding loops; other site 398527001171 ABC-type taurine transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG4525 398527001172 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 398527001173 Walker A/P-loop; other site 398527001174 ATP binding site [chemical binding]; other site 398527001175 Q-loop/lid; other site 398527001176 ABC transporter signature motif; other site 398527001177 Walker B; other site 398527001178 D-loop; other site 398527001179 H-loop/switch region; other site 398527001180 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 398527001181 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 398527001182 substrate binding pocket [chemical binding]; other site 398527001183 membrane-bound complex binding site; other site 398527001184 hinge residues; other site 398527001185 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 398527001186 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527001187 DNA-binding site [nucleotide binding]; DNA binding site 398527001188 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 398527001189 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527001190 homodimer interface [polypeptide binding]; other site 398527001191 catalytic residue [active] 398527001192 Transcriptional regulator [Transcription]; Region: IclR; COG1414 398527001193 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 398527001194 Bacterial transcriptional regulator; Region: IclR; pfam01614 398527001195 Transcriptional regulator [Transcription]; Region: IclR; COG1414 398527001196 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 398527001197 Bacterial transcriptional regulator; Region: IclR; pfam01614 398527001198 choline dehydrogenase; Validated; Region: PRK02106 398527001199 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 398527001200 metabolite-proton symporter; Region: 2A0106; TIGR00883 398527001201 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527001202 putative substrate translocation pore; other site 398527001203 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 398527001204 putative active site [active] 398527001205 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 398527001206 Transcriptional regulator [Transcription]; Region: IclR; COG1414 398527001207 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 398527001208 Bacterial transcriptional regulator; Region: IclR; pfam01614 398527001209 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 398527001210 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 398527001211 putative catalytic cysteine [active] 398527001212 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 398527001213 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 398527001214 Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926 398527001215 acyl-activating enzyme (AAE) consensus motif; other site 398527001216 putative AMP binding site [chemical binding]; other site 398527001217 putative active site [active] 398527001218 putative CoA binding site [chemical binding]; other site 398527001219 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527001220 D-galactonate transporter; Region: 2A0114; TIGR00893 398527001221 putative substrate translocation pore; other site 398527001222 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 398527001223 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 398527001224 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 398527001225 Sulfate transporter family; Region: Sulfate_transp; pfam00916 398527001226 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 398527001227 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527001228 active site 398527001229 phosphorylation site [posttranslational modification] 398527001230 intermolecular recognition site; other site 398527001231 dimerization interface [polypeptide binding]; other site 398527001232 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 398527001233 DNA binding site [nucleotide binding] 398527001234 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 398527001235 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 398527001236 dimerization interface [polypeptide binding]; other site 398527001237 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 398527001238 dimer interface [polypeptide binding]; other site 398527001239 phosphorylation site [posttranslational modification] 398527001240 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527001241 ATP binding site [chemical binding]; other site 398527001242 G-X-G motif; other site 398527001243 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 398527001244 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 398527001245 Response regulator receiver domain; Region: Response_reg; pfam00072 398527001246 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527001247 active site 398527001248 phosphorylation site [posttranslational modification] 398527001249 intermolecular recognition site; other site 398527001250 dimerization interface [polypeptide binding]; other site 398527001251 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 398527001252 dimerization interface [polypeptide binding]; other site 398527001253 putative DNA binding site [nucleotide binding]; other site 398527001254 putative Zn2+ binding site [ion binding]; other site 398527001255 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 398527001256 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 398527001257 active site 398527001258 FMN binding site [chemical binding]; other site 398527001259 substrate binding site [chemical binding]; other site 398527001260 homotetramer interface [polypeptide binding]; other site 398527001261 catalytic residue [active] 398527001262 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 398527001263 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 398527001264 DNA binding residues [nucleotide binding] 398527001265 RNA polymerase sigma factor; Provisional; Region: PRK12537 398527001266 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 398527001267 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 398527001268 DNA binding residues [nucleotide binding] 398527001269 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 398527001270 RibD C-terminal domain; Region: RibD_C; cl17279 398527001271 Domain of unknown function (DUF4410); Region: DUF4410; pfam14366 398527001272 Phasin protein; Region: Phasin_2; pfam09361 398527001273 Protein of unknown function (DUF2844); Region: DUF2844; pfam11005 398527001274 Protein of unknown function (DUF3443); Region: DUF3443; pfam11925 398527001275 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 398527001276 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 398527001277 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 398527001278 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 398527001279 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 398527001280 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 398527001281 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 398527001282 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 398527001283 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 398527001284 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 398527001285 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 398527001286 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 398527001287 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 398527001288 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 398527001289 Transcriptional regulator [Transcription]; Region: IclR; COG1414 398527001290 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 398527001291 Bacterial transcriptional regulator; Region: IclR; pfam01614 398527001292 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 398527001293 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 398527001294 substrate binding pocket [chemical binding]; other site 398527001295 membrane-bound complex binding site; other site 398527001296 hinge residues; other site 398527001297 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 398527001298 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527001299 dimer interface [polypeptide binding]; other site 398527001300 conserved gate region; other site 398527001301 putative PBP binding loops; other site 398527001302 ABC-ATPase subunit interface; other site 398527001303 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 398527001304 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 398527001305 Walker A/P-loop; other site 398527001306 ATP binding site [chemical binding]; other site 398527001307 Q-loop/lid; other site 398527001308 ABC transporter signature motif; other site 398527001309 Walker B; other site 398527001310 D-loop; other site 398527001311 H-loop/switch region; other site 398527001312 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 398527001313 putative active site [active] 398527001314 putative metal binding site [ion binding]; other site 398527001315 Transcriptional regulators [Transcription]; Region: MarR; COG1846 398527001316 MarR family; Region: MarR_2; cl17246 398527001317 Transcriptional regulators [Transcription]; Region: MarR; COG1846 398527001318 MarR family; Region: MarR_2; pfam12802 398527001319 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 398527001320 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 398527001321 HlyD family secretion protein; Region: HlyD_3; pfam13437 398527001322 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 398527001323 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527001324 putative substrate translocation pore; other site 398527001325 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527001326 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 398527001327 putative acyltransferase; Provisional; Region: PRK05790 398527001328 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 398527001329 dimer interface [polypeptide binding]; other site 398527001330 active site 398527001331 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 398527001332 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 398527001333 Nucleoside recognition; Region: Gate; pfam07670 398527001334 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 398527001335 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 398527001336 active site 398527001337 catalytic motif [active] 398527001338 Zn binding site [ion binding]; other site 398527001339 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 398527001340 active site 398527001341 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 398527001342 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 398527001343 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 398527001344 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 398527001345 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 398527001346 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 398527001347 hydroxyglutarate oxidase; Provisional; Region: PRK11728 398527001348 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 398527001349 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 398527001350 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 398527001351 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 398527001352 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 398527001353 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527001354 dimer interface [polypeptide binding]; other site 398527001355 conserved gate region; other site 398527001356 putative PBP binding loops; other site 398527001357 ABC-ATPase subunit interface; other site 398527001358 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 398527001359 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527001360 dimer interface [polypeptide binding]; other site 398527001361 conserved gate region; other site 398527001362 putative PBP binding loops; other site 398527001363 ABC-ATPase subunit interface; other site 398527001364 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 398527001365 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 398527001366 Walker A/P-loop; other site 398527001367 ATP binding site [chemical binding]; other site 398527001368 Q-loop/lid; other site 398527001369 ABC transporter signature motif; other site 398527001370 Walker B; other site 398527001371 D-loop; other site 398527001372 H-loop/switch region; other site 398527001373 TOBE domain; Region: TOBE_2; pfam08402 398527001374 Transcriptional regulator [Transcription]; Region: IclR; COG1414 398527001375 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 398527001376 Bacterial transcriptional regulator; Region: IclR; pfam01614 398527001377 outer membrane porin, OprD family; Region: OprD; pfam03573 398527001378 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 398527001379 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 398527001380 Walker A/P-loop; other site 398527001381 ATP binding site [chemical binding]; other site 398527001382 Q-loop/lid; other site 398527001383 ABC transporter signature motif; other site 398527001384 Walker B; other site 398527001385 D-loop; other site 398527001386 H-loop/switch region; other site 398527001387 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 398527001388 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 398527001389 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 398527001390 Walker A/P-loop; other site 398527001391 ATP binding site [chemical binding]; other site 398527001392 Q-loop/lid; other site 398527001393 ABC transporter signature motif; other site 398527001394 Walker B; other site 398527001395 D-loop; other site 398527001396 H-loop/switch region; other site 398527001397 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 398527001398 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 398527001399 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 398527001400 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527001401 dimer interface [polypeptide binding]; other site 398527001402 conserved gate region; other site 398527001403 putative PBP binding loops; other site 398527001404 ABC-ATPase subunit interface; other site 398527001405 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 398527001406 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527001407 dimer interface [polypeptide binding]; other site 398527001408 conserved gate region; other site 398527001409 putative PBP binding loops; other site 398527001410 ABC-ATPase subunit interface; other site 398527001411 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 398527001412 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 398527001413 peptide binding site [polypeptide binding]; other site 398527001414 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 398527001415 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 398527001416 non-specific DNA binding site [nucleotide binding]; other site 398527001417 salt bridge; other site 398527001418 sequence-specific DNA binding site [nucleotide binding]; other site 398527001419 Cupin domain; Region: Cupin_2; pfam07883 398527001420 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 398527001421 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527001422 putative substrate translocation pore; other site 398527001423 POT family; Region: PTR2; cl17359 398527001424 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 398527001425 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527001426 DNA-binding site [nucleotide binding]; DNA binding site 398527001427 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 398527001428 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527001429 homodimer interface [polypeptide binding]; other site 398527001430 catalytic residue [active] 398527001431 Bacterial DNA-binding protein; Region: Bac_DNA_binding; pfam00216 398527001432 IHF dimer interface [polypeptide binding]; other site 398527001433 IHF - DNA interface [nucleotide binding]; other site 398527001434 Uncharacterized conserved protein [Function unknown]; Region: COG2308 398527001435 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 398527001436 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 398527001437 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 398527001438 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 398527001439 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 398527001440 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 398527001441 Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765 398527001442 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 398527001443 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 398527001444 trimer interface [polypeptide binding]; other site 398527001445 eyelet of channel; other site 398527001446 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 398527001447 PA2301 is an uncharacterized Pseudomonas aeruginosa protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's...; Region: PA2301; cd04939 398527001448 putative deacylase active site [active] 398527001449 Cache domain; Region: Cache_2; pfam08269 398527001450 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 398527001451 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 398527001452 dimer interface [polypeptide binding]; other site 398527001453 putative CheW interface [polypeptide binding]; other site 398527001454 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 398527001455 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 398527001456 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 398527001457 Sulfate transporter family; Region: Sulfate_transp; pfam00916 398527001458 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 398527001459 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 398527001460 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 398527001461 FAD binding domain; Region: FAD_binding_4; pfam01565 398527001462 Berberine and berberine like; Region: BBE; pfam08031 398527001463 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642 398527001464 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 398527001465 NAD(P) binding site [chemical binding]; other site 398527001466 active site 398527001467 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 398527001468 putative active site [active] 398527001469 putative metal binding site [ion binding]; other site 398527001470 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 398527001471 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 398527001472 ATP binding site [chemical binding]; other site 398527001473 putative Mg++ binding site [ion binding]; other site 398527001474 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 398527001475 nucleotide binding region [chemical binding]; other site 398527001476 ATP-binding site [chemical binding]; other site 398527001477 DEAD/H associated; Region: DEAD_assoc; pfam08494 398527001478 Predicted amidohydrolase [General function prediction only]; Region: COG0388 398527001479 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 398527001480 active site 398527001481 catalytic triad [active] 398527001482 dimer interface [polypeptide binding]; other site 398527001483 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 398527001484 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 398527001485 Protein of unknown function, DUF488; Region: DUF488; pfam04343 398527001486 H-NS histone family; Region: Histone_HNS; pfam00816 398527001487 H-NS histone family; Region: Histone_HNS; pfam00816 398527001488 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 398527001489 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 398527001490 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 398527001491 putative active site [active] 398527001492 catalytic site [active] 398527001493 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 398527001494 putative active site [active] 398527001495 catalytic site [active] 398527001496 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 398527001497 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 398527001498 Uncharacterized conserved protein [Function unknown]; Region: COG1262 398527001499 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 398527001500 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 398527001501 Sulfatase; Region: Sulfatase; cl17466 398527001502 Sulfatase; Region: Sulfatase; cl17466 398527001503 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 398527001504 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527001505 active site 398527001506 phosphorylation site [posttranslational modification] 398527001507 intermolecular recognition site; other site 398527001508 dimerization interface [polypeptide binding]; other site 398527001509 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 398527001510 DNA binding residues [nucleotide binding] 398527001511 dimerization interface [polypeptide binding]; other site 398527001512 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 398527001513 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 398527001514 Histidine kinase; Region: HisKA_3; pfam07730 398527001515 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527001516 ATP binding site [chemical binding]; other site 398527001517 Mg2+ binding site [ion binding]; other site 398527001518 G-X-G motif; other site 398527001519 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 398527001520 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 398527001521 Na binding site [ion binding]; other site 398527001522 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 398527001523 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 398527001524 Protein of unknown function (DUF3348); Region: DUF3348; pfam11828 398527001525 Domain of unknown function (DUF802); Region: DUF802; pfam05650 398527001526 hypothetical protein; Provisional; Region: PRK09040 398527001527 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 398527001528 ligand binding site [chemical binding]; other site 398527001529 Protein of unknown function (DUF2894); Region: DUF2894; pfam11445 398527001530 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 398527001531 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 398527001532 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 398527001533 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527001534 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 398527001535 dimerization interface [polypeptide binding]; other site 398527001536 tellurium resistance terB-like protein; Region: terB_like; cl11965 398527001537 metal binding site [ion binding]; metal-binding site 398527001538 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 398527001539 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 398527001540 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 398527001541 dimerization interface [polypeptide binding]; other site 398527001542 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 398527001543 dimer interface [polypeptide binding]; other site 398527001544 phosphorylation site [posttranslational modification] 398527001545 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527001546 ATP binding site [chemical binding]; other site 398527001547 Mg2+ binding site [ion binding]; other site 398527001548 G-X-G motif; other site 398527001549 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 398527001550 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527001551 active site 398527001552 phosphorylation site [posttranslational modification] 398527001553 intermolecular recognition site; other site 398527001554 dimerization interface [polypeptide binding]; other site 398527001555 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 398527001556 DNA binding site [nucleotide binding] 398527001557 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 398527001558 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 398527001559 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 398527001560 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 398527001561 catalytic residues [active] 398527001562 methionine sulfoxide reductase A; Provisional; Region: PRK13014 398527001563 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 398527001564 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 398527001565 motif II; other site 398527001566 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527001567 active site 398527001568 phosphorylation site [posttranslational modification] 398527001569 intermolecular recognition site; other site 398527001570 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 398527001571 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527001572 ATP binding site [chemical binding]; other site 398527001573 G-X-G motif; other site 398527001574 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 398527001575 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 398527001576 active site 398527001577 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 398527001578 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 398527001579 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 398527001580 Uncharacterized conserved protein [Function unknown]; Region: COG3246 398527001581 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 398527001582 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 398527001583 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 398527001584 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 398527001585 conserved cys residue [active] 398527001586 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527001587 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 398527001588 Predicted transcriptional regulators [Transcription]; Region: COG1733 398527001589 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 398527001590 Bacterial protein of unknown function (DUF934); Region: DUF934; pfam06073 398527001591 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 398527001592 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 398527001593 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 398527001594 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 398527001595 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 398527001596 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527001597 DNA-binding site [nucleotide binding]; DNA binding site 398527001598 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 398527001599 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527001600 homodimer interface [polypeptide binding]; other site 398527001601 catalytic residue [active] 398527001602 succinic semialdehyde dehydrogenase; Region: PLN02278 398527001603 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 398527001604 tetramerization interface [polypeptide binding]; other site 398527001605 NAD(P) binding site [chemical binding]; other site 398527001606 catalytic residues [active] 398527001607 4-aminobutyrate aminotransferase; Provisional; Region: PRK07495 398527001608 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 398527001609 inhibitor-cofactor binding pocket; inhibition site 398527001610 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527001611 catalytic residue [active] 398527001612 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 398527001613 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527001614 DNA-binding site [nucleotide binding]; DNA binding site 398527001615 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 398527001616 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527001617 homodimer interface [polypeptide binding]; other site 398527001618 catalytic residue [active] 398527001619 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 398527001620 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 398527001621 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 398527001622 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527001623 dimer interface [polypeptide binding]; other site 398527001624 conserved gate region; other site 398527001625 ABC-ATPase subunit interface; other site 398527001626 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 398527001627 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 398527001628 substrate binding pocket [chemical binding]; other site 398527001629 membrane-bound complex binding site; other site 398527001630 hinge residues; other site 398527001631 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 398527001632 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 398527001633 Walker A/P-loop; other site 398527001634 ATP binding site [chemical binding]; other site 398527001635 Q-loop/lid; other site 398527001636 ABC transporter signature motif; other site 398527001637 Walker B; other site 398527001638 D-loop; other site 398527001639 H-loop/switch region; other site 398527001640 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_7; cd03862 398527001641 putative active site [active] 398527001642 Zn binding site [ion binding]; other site 398527001643 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 398527001644 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 398527001645 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 398527001646 Cation efflux family; Region: Cation_efflux; pfam01545 398527001647 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 398527001648 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 398527001649 active site 398527001650 catalytic tetrad [active] 398527001651 Purine nucleoside permease (NUP); Region: NUP; pfam06516 398527001652 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 398527001653 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527001654 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527001655 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 398527001656 putative effector binding pocket; other site 398527001657 putative dimerization interface [polypeptide binding]; other site 398527001658 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 398527001659 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 398527001660 substrate binding pocket [chemical binding]; other site 398527001661 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 398527001662 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 398527001663 HlyD family secretion protein; Region: HlyD_3; pfam13437 398527001664 AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873 398527001665 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 398527001666 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 398527001667 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 398527001668 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 398527001669 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 398527001670 active site 398527001671 non-prolyl cis peptide bond; other site 398527001672 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 398527001673 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 398527001674 Walker A/P-loop; other site 398527001675 ATP binding site [chemical binding]; other site 398527001676 Q-loop/lid; other site 398527001677 ABC transporter signature motif; other site 398527001678 Walker B; other site 398527001679 D-loop; other site 398527001680 H-loop/switch region; other site 398527001681 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 398527001682 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527001683 dimer interface [polypeptide binding]; other site 398527001684 conserved gate region; other site 398527001685 ABC-ATPase subunit interface; other site 398527001686 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 398527001687 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 398527001688 Flavin binding site [chemical binding]; other site 398527001689 manganese transport protein MntH; Reviewed; Region: PRK00701 398527001690 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 398527001691 transcriptional activator FlhC; Provisional; Region: PRK12860 398527001692 transcriptional activator FlhD; Provisional; Region: PRK02909 398527001693 Predicted transporter component [General function prediction only]; Region: COG2391 398527001694 Sulphur transport; Region: Sulf_transp; pfam04143 398527001695 Sulphur transport; Region: Sulf_transp; pfam04143 398527001696 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 398527001697 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 398527001698 Coenzyme A binding pocket [chemical binding]; other site 398527001699 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 398527001700 non-specific DNA binding site [nucleotide binding]; other site 398527001701 salt bridge; other site 398527001702 sequence-specific DNA binding site [nucleotide binding]; other site 398527001703 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 398527001704 putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683 398527001705 SnoaL-like domain; Region: SnoaL_2; pfam12680 398527001706 Fucose dissimilation pathway protein FucU [Carbohydrate transport and metabolism]; Region: FucU; COG4154 398527001707 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 398527001708 dimer interface [polypeptide binding]; other site 398527001709 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 398527001710 metal binding site [ion binding]; metal-binding site 398527001711 Predicted membrane protein [Function unknown]; Region: COG2259 398527001712 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527001713 putative substrate translocation pore; other site 398527001714 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527001715 metabolite-proton symporter; Region: 2A0106; TIGR00883 398527001716 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527001717 putative substrate translocation pore; other site 398527001718 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 398527001719 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527001720 active site 398527001721 phosphorylation site [posttranslational modification] 398527001722 intermolecular recognition site; other site 398527001723 dimerization interface [polypeptide binding]; other site 398527001724 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 398527001725 DNA binding site [nucleotide binding] 398527001726 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 398527001727 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 398527001728 inhibitor site; inhibition site 398527001729 active site 398527001730 dimer interface [polypeptide binding]; other site 398527001731 catalytic residue [active] 398527001732 hydroxyproline-2-epimerase; Provisional; Region: PRK13970 398527001733 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 398527001734 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 398527001735 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 398527001736 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 398527001737 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 398527001738 PAS fold; Region: PAS_4; pfam08448 398527001739 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 398527001740 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527001741 MarR family; Region: MarR_2; cl17246 398527001742 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 398527001743 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 398527001744 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 398527001745 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 398527001746 dimer interface [polypeptide binding]; other site 398527001747 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 398527001748 active site 398527001749 Fe binding site [ion binding]; other site 398527001750 Dehydroquinase class II; Region: DHquinase_II; pfam01220 398527001751 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 398527001752 active site 398527001753 trimer interface [polypeptide binding]; other site 398527001754 dimer interface [polypeptide binding]; other site 398527001755 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 398527001756 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 398527001757 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 398527001758 shikimate binding site; other site 398527001759 NAD(P) binding site [chemical binding]; other site 398527001760 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527001761 D-galactonate transporter; Region: 2A0114; TIGR00893 398527001762 putative substrate translocation pore; other site 398527001763 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527001764 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 398527001765 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 398527001766 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 398527001767 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 398527001768 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5343 398527001769 Anti-sigma-K factor rskA; Region: RskA; pfam10099 398527001770 RNA polymerase sigma factor; Provisional; Region: PRK12514 398527001771 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 398527001772 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 398527001773 DNA binding residues [nucleotide binding] 398527001774 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 398527001775 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 398527001776 inhibitor site; inhibition site 398527001777 active site 398527001778 dimer interface [polypeptide binding]; other site 398527001779 catalytic residue [active] 398527001780 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527001781 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527001782 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 398527001783 putative dimerization interface [polypeptide binding]; other site 398527001784 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 398527001785 Transglycosylase; Region: Transgly; pfam00912 398527001786 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 398527001787 MarR family; Region: MarR_2; pfam12802 398527001788 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 398527001789 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 398527001790 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 398527001791 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 398527001792 Walker A/P-loop; other site 398527001793 ATP binding site [chemical binding]; other site 398527001794 Q-loop/lid; other site 398527001795 ABC transporter signature motif; other site 398527001796 Walker B; other site 398527001797 D-loop; other site 398527001798 H-loop/switch region; other site 398527001799 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 398527001800 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 398527001801 TM-ABC transporter signature motif; other site 398527001802 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 398527001803 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 398527001804 ligand binding site [chemical binding]; other site 398527001805 Flagellar regulator YcgR; Region: YcgR; pfam07317 398527001806 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 398527001807 PilZ domain; Region: PilZ; pfam07238 398527001808 Transcriptional regulators [Transcription]; Region: PurR; COG1609 398527001809 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 398527001810 DNA binding site [nucleotide binding] 398527001811 domain linker motif; other site 398527001812 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 398527001813 dimerization interface [polypeptide binding]; other site 398527001814 ligand binding site [chemical binding]; other site 398527001815 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 398527001816 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 398527001817 Walker A/P-loop; other site 398527001818 ATP binding site [chemical binding]; other site 398527001819 Q-loop/lid; other site 398527001820 ABC transporter signature motif; other site 398527001821 Walker B; other site 398527001822 D-loop; other site 398527001823 H-loop/switch region; other site 398527001824 TOBE domain; Region: TOBE_2; pfam08402 398527001825 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 398527001826 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 398527001827 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 398527001828 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 398527001829 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 398527001830 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 398527001831 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527001832 dimer interface [polypeptide binding]; other site 398527001833 conserved gate region; other site 398527001834 putative PBP binding loops; other site 398527001835 ABC-ATPase subunit interface; other site 398527001836 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 398527001837 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527001838 dimer interface [polypeptide binding]; other site 398527001839 conserved gate region; other site 398527001840 putative PBP binding loops; other site 398527001841 ABC-ATPase subunit interface; other site 398527001842 Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461 398527001843 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 398527001844 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 398527001845 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 398527001846 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 398527001847 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 398527001848 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 398527001849 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 398527001850 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 398527001851 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 398527001852 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 398527001853 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 398527001854 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 398527001855 ligand binding site [chemical binding]; other site 398527001856 flexible hinge region; other site 398527001857 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 398527001858 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 398527001859 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 398527001860 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 398527001861 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 398527001862 ligand binding site [chemical binding]; other site 398527001863 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 398527001864 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 398527001865 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 398527001866 catalytic residues [active] 398527001867 Uncharacterized conserved protein [Function unknown]; Region: COG3791 398527001868 osmolarity response regulator; Provisional; Region: ompR; PRK09468 398527001869 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527001870 active site 398527001871 phosphorylation site [posttranslational modification] 398527001872 intermolecular recognition site; other site 398527001873 dimerization interface [polypeptide binding]; other site 398527001874 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 398527001875 DNA binding site [nucleotide binding] 398527001876 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 398527001877 dimerization interface [polypeptide binding]; other site 398527001878 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527001879 ATP binding site [chemical binding]; other site 398527001880 Mg2+ binding site [ion binding]; other site 398527001881 G-X-G motif; other site 398527001882 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 398527001883 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 398527001884 ligand binding site [chemical binding]; other site 398527001885 flexible hinge region; other site 398527001886 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 398527001887 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 398527001888 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 398527001889 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 398527001890 Uncharacterized protein conserved in bacteria (DUF2322); Region: DUF2322; pfam10084 398527001891 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 398527001892 active site 398527001893 metal binding site [ion binding]; metal-binding site 398527001894 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 398527001895 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 398527001896 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 398527001897 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 398527001898 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 398527001899 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 398527001900 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 398527001901 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 398527001902 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 398527001903 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 398527001904 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 398527001905 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 398527001906 ATP binding site [chemical binding]; other site 398527001907 Walker A motif; other site 398527001908 hexamer interface [polypeptide binding]; other site 398527001909 Walker B motif; other site 398527001910 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 398527001911 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 398527001912 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 398527001913 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 398527001914 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 398527001915 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 398527001916 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 398527001917 TadE-like protein; Region: TadE; pfam07811 398527001918 TadE-like protein; Region: TadE; pfam07811 398527001919 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 398527001920 metal ion-dependent adhesion site (MIDAS); other site 398527001921 Phospholipid methyltransferase; Region: PEMT; cl17370 398527001922 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 398527001923 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 398527001924 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 398527001925 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 398527001926 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 398527001927 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 398527001928 N-terminal plug; other site 398527001929 ligand-binding site [chemical binding]; other site 398527001930 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 398527001931 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 398527001932 binding surface 398527001933 TPR motif; other site 398527001934 TPR repeat; Region: TPR_11; pfam13414 398527001935 Tetratricopeptide repeat; Region: TPR_17; pfam13431 398527001936 Tetratricopeptide repeat; Region: TPR_12; pfam13424 398527001937 TPR repeat; Region: TPR_11; pfam13414 398527001938 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 398527001939 binding surface 398527001940 TPR motif; other site 398527001941 TPR repeat; Region: TPR_11; pfam13414 398527001942 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 398527001943 binding surface 398527001944 TPR motif; other site 398527001945 TPR repeat; Region: TPR_11; pfam13414 398527001946 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 398527001947 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527001948 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527001949 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 398527001950 dimerization interface [polypeptide binding]; other site 398527001951 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 398527001952 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 398527001953 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 398527001954 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 398527001955 trimer interface [polypeptide binding]; other site 398527001956 eyelet of channel; other site 398527001957 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 398527001958 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 398527001959 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 398527001960 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 398527001961 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 398527001962 non-specific DNA binding site [nucleotide binding]; other site 398527001963 salt bridge; other site 398527001964 sequence-specific DNA binding site [nucleotide binding]; other site 398527001965 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 398527001966 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 398527001967 trimer interface [polypeptide binding]; other site 398527001968 eyelet of channel; other site 398527001969 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 398527001970 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 398527001971 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 398527001972 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 398527001973 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 398527001974 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 398527001975 Transcriptional regulators [Transcription]; Region: GntR; COG1802 398527001976 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527001977 DNA-binding site [nucleotide binding]; DNA binding site 398527001978 FCD domain; Region: FCD; pfam07729 398527001979 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 398527001980 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527001981 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527001982 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 398527001983 putative dimerization interface [polypeptide binding]; other site 398527001984 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 398527001985 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 398527001986 substrate binding site [chemical binding]; other site 398527001987 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 398527001988 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 398527001989 substrate binding site [chemical binding]; other site 398527001990 ligand binding site [chemical binding]; other site 398527001991 benzoate transport; Region: 2A0115; TIGR00895 398527001992 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527001993 putative substrate translocation pore; other site 398527001994 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527001995 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 398527001996 Transcriptional regulators [Transcription]; Region: FadR; COG2186 398527001997 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527001998 DNA-binding site [nucleotide binding]; DNA binding site 398527001999 FCD domain; Region: FCD; pfam07729 398527002000 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 398527002001 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 398527002002 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527002003 putative substrate translocation pore; other site 398527002004 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 398527002005 GAF domain; Region: GAF; pfam01590 398527002006 GAF domain; Region: GAF_2; pfam13185 398527002007 benzoate transport; Region: 2A0115; TIGR00895 398527002008 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527002009 putative substrate translocation pore; other site 398527002010 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 398527002011 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 398527002012 DNA polymerase II; Reviewed; Region: PRK05762 398527002013 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 398527002014 active site 398527002015 catalytic site [active] 398527002016 substrate binding site [chemical binding]; other site 398527002017 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 398527002018 active site 398527002019 metal-binding site 398527002020 PRC-barrel domain; Region: PRC; pfam05239 398527002021 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 398527002022 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 398527002023 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 398527002024 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 398527002025 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 398527002026 Protein of unknown function (DUF3138); Region: DUF3138; pfam11336 398527002027 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 398527002028 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 398527002029 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527002030 dimer interface [polypeptide binding]; other site 398527002031 conserved gate region; other site 398527002032 putative PBP binding loops; other site 398527002033 ABC-ATPase subunit interface; other site 398527002034 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527002035 dimer interface [polypeptide binding]; other site 398527002036 conserved gate region; other site 398527002037 putative PBP binding loops; other site 398527002038 ABC-ATPase subunit interface; other site 398527002039 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 398527002040 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 398527002041 Walker A/P-loop; other site 398527002042 ATP binding site [chemical binding]; other site 398527002043 Q-loop/lid; other site 398527002044 ABC transporter signature motif; other site 398527002045 Walker B; other site 398527002046 D-loop; other site 398527002047 H-loop/switch region; other site 398527002048 TOBE domain; Region: TOBE_2; pfam08402 398527002049 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 398527002050 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 398527002051 putative aminotransferase; Validated; Region: PRK07480 398527002052 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 398527002053 inhibitor-cofactor binding pocket; inhibition site 398527002054 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527002055 catalytic residue [active] 398527002056 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 398527002057 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 398527002058 Peptidase C26; Region: Peptidase_C26; pfam07722 398527002059 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 398527002060 catalytic triad [active] 398527002061 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 398527002062 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 398527002063 non-specific DNA binding site [nucleotide binding]; other site 398527002064 salt bridge; other site 398527002065 sequence-specific DNA binding site [nucleotide binding]; other site 398527002066 Cupin domain; Region: Cupin_2; pfam07883 398527002067 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 398527002068 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 398527002069 NAD(P) binding site [chemical binding]; other site 398527002070 catalytic residues [active] 398527002071 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527002072 Major Facilitator Superfamily; Region: MFS_1; pfam07690 398527002073 putative substrate translocation pore; other site 398527002074 Transcriptional regulators [Transcription]; Region: MarR; COG1846 398527002075 MarR family; Region: MarR_2; pfam12802 398527002076 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 398527002077 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 398527002078 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 398527002079 active site residue [active] 398527002080 Cupin domain; Region: Cupin_2; cl17218 398527002081 PA26 p53-induced protein (sestrin); Region: PA26; pfam04636 398527002082 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 398527002083 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 398527002084 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 398527002085 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527002086 putative substrate translocation pore; other site 398527002087 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 398527002088 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527002089 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 398527002090 dimerization interface [polypeptide binding]; other site 398527002091 substrate binding pocket [chemical binding]; other site 398527002092 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 398527002093 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]; Region: COG5001 398527002094 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 398527002095 metal binding site [ion binding]; metal-binding site 398527002096 active site 398527002097 I-site; other site 398527002098 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 398527002099 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 398527002100 IHF dimer interface [polypeptide binding]; other site 398527002101 IHF - DNA interface [nucleotide binding]; other site 398527002102 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 398527002103 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 398527002104 Protein of unknown function DUF72; Region: DUF72; pfam01904 398527002105 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 398527002106 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 398527002107 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 398527002108 isovaleryl-CoA dehydrogenase; Region: PLN02519 398527002109 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 398527002110 substrate binding site [chemical binding]; other site 398527002111 FAD binding site [chemical binding]; other site 398527002112 catalytic base [active] 398527002113 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 398527002114 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 398527002115 enoyl-CoA hydratase; Provisional; Region: PRK05995 398527002116 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 398527002117 substrate binding site [chemical binding]; other site 398527002118 oxyanion hole (OAH) forming residues; other site 398527002119 trimer interface [polypeptide binding]; other site 398527002120 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 398527002121 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 398527002122 ATP-grasp domain; Region: ATP-grasp_4; cl17255 398527002123 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 398527002124 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 398527002125 carboxyltransferase (CT) interaction site; other site 398527002126 biotinylation site [posttranslational modification]; other site 398527002127 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 398527002128 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 398527002129 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 398527002130 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 398527002131 S-adenosylmethionine binding site [chemical binding]; other site 398527002132 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 398527002133 putative uracil binding site [chemical binding]; other site 398527002134 putative active site [active] 398527002135 Protein of unknown function, DUF488; Region: DUF488; pfam04343 398527002136 CAAX protease self-immunity; Region: Abi; pfam02517 398527002137 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 398527002138 active site 398527002139 barstar interaction site; other site 398527002140 aspartate racemase; Region: asp_race; TIGR00035 398527002141 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 398527002142 tyrosine kinase; Provisional; Region: PRK11519 398527002143 Chain length determinant protein; Region: Wzz; pfam02706 398527002144 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 398527002145 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 398527002146 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 398527002147 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 398527002148 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 398527002149 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 398527002150 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 398527002151 NAD binding site [chemical binding]; other site 398527002152 substrate binding site [chemical binding]; other site 398527002153 homodimer interface [polypeptide binding]; other site 398527002154 active site 398527002155 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 398527002156 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 398527002157 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 398527002158 putative ADP-binding pocket [chemical binding]; other site 398527002159 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 398527002160 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 398527002161 putative ADP-binding pocket [chemical binding]; other site 398527002162 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 398527002163 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 398527002164 putative ADP-binding pocket [chemical binding]; other site 398527002165 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u1; cd10925 398527002166 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 398527002167 NodB motif; other site 398527002168 putative active site [active] 398527002169 putative catalytic site [active] 398527002170 putative Zn binding site [ion binding]; other site 398527002171 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 398527002172 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 398527002173 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 398527002174 putative ADP-binding pocket [chemical binding]; other site 398527002175 This subfamily is composed of uncharacterized bacterial glycosyltransferases in the MraY-like family. This family contains both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases, which...; Region: GT_MraY_like; cd06912 398527002176 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 398527002177 Mg++ binding site [ion binding]; other site 398527002178 putative catalytic motif [active] 398527002179 Transcriptional regulators [Transcription]; Region: FadR; COG2186 398527002180 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527002181 DNA-binding site [nucleotide binding]; DNA binding site 398527002182 FCD domain; Region: FCD; pfam07729 398527002183 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 398527002184 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 398527002185 glutaminase active site [active] 398527002186 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 398527002187 dimer interface [polypeptide binding]; other site 398527002188 active site 398527002189 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 398527002190 dimer interface [polypeptide binding]; other site 398527002191 active site 398527002192 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 398527002193 active site 398527002194 catalytic triad [active] 398527002195 oxyanion hole [active] 398527002196 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 398527002197 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 398527002198 acyl-activating enzyme (AAE) consensus motif; other site 398527002199 AMP binding site [chemical binding]; other site 398527002200 active site 398527002201 CoA binding site [chemical binding]; other site 398527002202 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 398527002203 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 398527002204 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 398527002205 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 398527002206 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 398527002207 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 398527002208 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 398527002209 putative active site pocket [active] 398527002210 putative metal binding site [ion binding]; other site 398527002211 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527002212 metabolite-proton symporter; Region: 2A0106; TIGR00883 398527002213 putative substrate translocation pore; other site 398527002214 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 398527002215 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 398527002216 putative NAD(P) binding site [chemical binding]; other site 398527002217 catalytic Zn binding site [ion binding]; other site 398527002218 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527002219 D-galactonate transporter; Region: 2A0114; TIGR00893 398527002220 putative substrate translocation pore; other site 398527002221 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 398527002222 Transcriptional regulators [Transcription]; Region: GntR; COG1802 398527002223 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527002224 DNA-binding site [nucleotide binding]; DNA binding site 398527002225 FCD domain; Region: FCD; pfam07729 398527002226 ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]; Region: APA2; COG4360 398527002227 ATP adenylyltransferase; Region: ATP_transf; pfam09830 398527002228 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 398527002229 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 398527002230 conserved cys residue [active] 398527002231 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527002232 Predicted amidohydrolase [General function prediction only]; Region: COG0388 398527002233 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 398527002234 putative active site [active] 398527002235 catalytic triad [active] 398527002236 putative dimer interface [polypeptide binding]; other site 398527002237 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 398527002238 active site clefts [active] 398527002239 zinc binding site [ion binding]; other site 398527002240 dimer interface [polypeptide binding]; other site 398527002241 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 398527002242 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 398527002243 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 398527002244 Domain of unknown function (DUF336); Region: DUF336; cl01249 398527002245 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 398527002246 putative dimer interface [polypeptide binding]; other site 398527002247 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 398527002248 ligand binding site [chemical binding]; other site 398527002249 Zn binding site [ion binding]; other site 398527002250 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 398527002251 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 398527002252 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 398527002253 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 398527002254 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 398527002255 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 398527002256 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 398527002257 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 398527002258 AMP-binding enzyme; Region: AMP-binding; pfam00501 398527002259 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 398527002260 acyl-activating enzyme (AAE) consensus motif; other site 398527002261 active site 398527002262 AMP binding site [chemical binding]; other site 398527002263 CoA binding site [chemical binding]; other site 398527002264 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 398527002265 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 398527002266 trimer interface [polypeptide binding]; other site 398527002267 eyelet of channel; other site 398527002268 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 398527002269 heme binding pocket [chemical binding]; other site 398527002270 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 398527002271 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 398527002272 substrate binding pocket [chemical binding]; other site 398527002273 membrane-bound complex binding site; other site 398527002274 hinge residues; other site 398527002275 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 398527002276 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 398527002277 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 398527002278 Protein export membrane protein; Region: SecD_SecF; cl14618 398527002279 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 398527002280 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 398527002281 HlyD family secretion protein; Region: HlyD_3; pfam13437 398527002282 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 398527002283 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 398527002284 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 398527002285 Walker A/P-loop; other site 398527002286 ATP binding site [chemical binding]; other site 398527002287 Q-loop/lid; other site 398527002288 ABC transporter signature motif; other site 398527002289 Walker B; other site 398527002290 D-loop; other site 398527002291 H-loop/switch region; other site 398527002292 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527002293 active site 398527002294 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 398527002295 phosphorylation site [posttranslational modification] 398527002296 intermolecular recognition site; other site 398527002297 dimerization interface [polypeptide binding]; other site 398527002298 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 398527002299 dimer interface [polypeptide binding]; other site 398527002300 phosphorylation site [posttranslational modification] 398527002301 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527002302 ATP binding site [chemical binding]; other site 398527002303 G-X-G motif; other site 398527002304 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 398527002305 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527002306 ATP binding site [chemical binding]; other site 398527002307 Mg2+ binding site [ion binding]; other site 398527002308 G-X-G motif; other site 398527002309 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 398527002310 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527002311 active site 398527002312 phosphorylation site [posttranslational modification] 398527002313 intermolecular recognition site; other site 398527002314 dimerization interface [polypeptide binding]; other site 398527002315 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 398527002316 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527002317 active site 398527002318 phosphorylation site [posttranslational modification] 398527002319 intermolecular recognition site; other site 398527002320 dimerization interface [polypeptide binding]; other site 398527002321 Protein of unknown function (DUF3563); Region: DUF3563; pfam12086 398527002322 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 398527002323 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 398527002324 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 398527002325 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527002326 active site 398527002327 phosphorylation site [posttranslational modification] 398527002328 intermolecular recognition site; other site 398527002329 dimerization interface [polypeptide binding]; other site 398527002330 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 398527002331 DNA binding site [nucleotide binding] 398527002332 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 398527002333 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 398527002334 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 398527002335 active site 398527002336 LssY C-terminus; Region: LssY_C; pfam14067 398527002337 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 398527002338 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 398527002339 Zn2+ binding site [ion binding]; other site 398527002340 Mg2+ binding site [ion binding]; other site 398527002341 OsmC-like protein; Region: OsmC; cl00767 398527002342 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 398527002343 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 398527002344 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 398527002345 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 398527002346 putative DNA binding site [nucleotide binding]; other site 398527002347 putative Zn2+ binding site [ion binding]; other site 398527002348 AsnC family; Region: AsnC_trans_reg; pfam01037 398527002349 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 398527002350 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 398527002351 hypothetical protein; Provisional; Region: PRK02237 398527002352 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 398527002353 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 398527002354 peptidase domain interface [polypeptide binding]; other site 398527002355 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 398527002356 active site 398527002357 catalytic triad [active] 398527002358 calcium binding site [ion binding]; other site 398527002359 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 398527002360 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 398527002361 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 398527002362 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 398527002363 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 398527002364 homodimer interface [polypeptide binding]; other site 398527002365 NAD binding pocket [chemical binding]; other site 398527002366 ATP binding pocket [chemical binding]; other site 398527002367 Mg binding site [ion binding]; other site 398527002368 active-site loop [active] 398527002369 ABC1 family; Region: ABC1; cl17513 398527002370 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 398527002371 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 398527002372 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 398527002373 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 398527002374 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 398527002375 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 398527002376 2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT; Region: PhnT; TIGR03258 398527002377 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 398527002378 Walker A/P-loop; other site 398527002379 ATP binding site [chemical binding]; other site 398527002380 Q-loop/lid; other site 398527002381 ABC transporter signature motif; other site 398527002382 Walker B; other site 398527002383 D-loop; other site 398527002384 H-loop/switch region; other site 398527002385 TOBE domain; Region: TOBE_2; pfam08402 398527002386 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 398527002387 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527002388 dimer interface [polypeptide binding]; other site 398527002389 conserved gate region; other site 398527002390 putative PBP binding loops; other site 398527002391 ABC-ATPase subunit interface; other site 398527002392 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527002393 dimer interface [polypeptide binding]; other site 398527002394 conserved gate region; other site 398527002395 ABC-ATPase subunit interface; other site 398527002396 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 398527002397 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527002398 DNA-binding site [nucleotide binding]; DNA binding site 398527002399 FCD domain; Region: FCD; pfam07729 398527002400 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 398527002401 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 398527002402 putative phosphonoacetaldehyde dehydrogenase; Region: PhnAcAld_DH; TIGR03250 398527002403 Streptomyces putative phosphonoformaldehyde dehydrogenase PhpJ-like; Region: ALDH_PhpJ; cd07146 398527002404 NAD(P) binding site [chemical binding]; other site 398527002405 catalytic residues [active] 398527002406 phosphonate degradation operons associated HDIG domain protein; Region: Phn-HD; TIGR03276 398527002407 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527002408 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527002409 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 398527002410 putative effector binding pocket; other site 398527002411 dimerization interface [polypeptide binding]; other site 398527002412 Fusaric acid resistance protein family; Region: FUSC; pfam04632 398527002413 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 398527002414 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 398527002415 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 398527002416 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 398527002417 MgtC family; Region: MgtC; pfam02308 398527002418 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 398527002419 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 398527002420 putative active site [active] 398527002421 putative metal binding site [ion binding]; other site 398527002422 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 398527002423 putative FMN binding site [chemical binding]; other site 398527002424 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 398527002425 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 398527002426 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 398527002427 putative ligand binding site [chemical binding]; other site 398527002428 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 398527002429 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 398527002430 Walker A/P-loop; other site 398527002431 ATP binding site [chemical binding]; other site 398527002432 Q-loop/lid; other site 398527002433 ABC transporter signature motif; other site 398527002434 Walker B; other site 398527002435 D-loop; other site 398527002436 H-loop/switch region; other site 398527002437 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 398527002438 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 398527002439 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 398527002440 TM-ABC transporter signature motif; other site 398527002441 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 398527002442 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 398527002443 TM-ABC transporter signature motif; other site 398527002444 benzoate transport; Region: 2A0115; TIGR00895 398527002445 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527002446 putative substrate translocation pore; other site 398527002447 hypothetical protein; Provisional; Region: PRK05463 398527002448 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527002449 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527002450 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 398527002451 dimerization interface [polypeptide binding]; other site 398527002452 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 398527002453 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 398527002454 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293 398527002455 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 398527002456 malonate decarboxylase, gamma subunit; Region: malonate_gamma; TIGR03134 398527002457 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 398527002458 malonate decarboxylase subunit delta; Provisional; Region: PRK01220 398527002459 triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237 398527002460 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 398527002461 Coenzyme A transferase; Region: CoA_trans; cl17247 398527002462 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 398527002463 Transcriptional regulators [Transcription]; Region: GntR; COG1802 398527002464 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527002465 DNA-binding site [nucleotide binding]; DNA binding site 398527002466 FCD domain; Region: FCD; pfam07729 398527002467 benzoate transport; Region: 2A0115; TIGR00895 398527002468 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527002469 putative substrate translocation pore; other site 398527002470 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 398527002471 EamA-like transporter family; Region: EamA; pfam00892 398527002472 EamA-like transporter family; Region: EamA; pfam00892 398527002473 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527002474 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 398527002475 dimerization interface [polypeptide binding]; other site 398527002476 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 398527002477 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 398527002478 Walker A/P-loop; other site 398527002479 ATP binding site [chemical binding]; other site 398527002480 Q-loop/lid; other site 398527002481 ABC transporter signature motif; other site 398527002482 Walker B; other site 398527002483 D-loop; other site 398527002484 H-loop/switch region; other site 398527002485 TOBE domain; Region: TOBE_2; pfam08402 398527002486 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 398527002487 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527002488 dimer interface [polypeptide binding]; other site 398527002489 conserved gate region; other site 398527002490 ABC-ATPase subunit interface; other site 398527002491 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527002492 dimer interface [polypeptide binding]; other site 398527002493 conserved gate region; other site 398527002494 putative PBP binding loops; other site 398527002495 ABC-ATPase subunit interface; other site 398527002496 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 398527002497 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 398527002498 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 398527002499 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 398527002500 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 398527002501 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 398527002502 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 398527002503 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 398527002504 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 398527002505 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 398527002506 substrate binding pocket [chemical binding]; other site 398527002507 membrane-bound complex binding site; other site 398527002508 hinge residues; other site 398527002509 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 398527002510 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527002511 dimer interface [polypeptide binding]; other site 398527002512 conserved gate region; other site 398527002513 putative PBP binding loops; other site 398527002514 ABC-ATPase subunit interface; other site 398527002515 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527002516 dimer interface [polypeptide binding]; other site 398527002517 conserved gate region; other site 398527002518 putative PBP binding loops; other site 398527002519 ABC-ATPase subunit interface; other site 398527002520 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 398527002521 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 398527002522 Walker A/P-loop; other site 398527002523 ATP binding site [chemical binding]; other site 398527002524 Q-loop/lid; other site 398527002525 ABC transporter signature motif; other site 398527002526 Walker B; other site 398527002527 D-loop; other site 398527002528 H-loop/switch region; other site 398527002529 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 398527002530 active sites [active] 398527002531 tetramer interface [polypeptide binding]; other site 398527002532 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 398527002533 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527002534 DNA-binding site [nucleotide binding]; DNA binding site 398527002535 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 398527002536 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 398527002537 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527002538 DNA-binding site [nucleotide binding]; DNA binding site 398527002539 UTRA domain; Region: UTRA; pfam07702 398527002540 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 398527002541 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 398527002542 Walker A/P-loop; other site 398527002543 ATP binding site [chemical binding]; other site 398527002544 Q-loop/lid; other site 398527002545 ABC transporter signature motif; other site 398527002546 Walker B; other site 398527002547 D-loop; other site 398527002548 H-loop/switch region; other site 398527002549 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527002550 dimer interface [polypeptide binding]; other site 398527002551 conserved gate region; other site 398527002552 putative PBP binding loops; other site 398527002553 ABC-ATPase subunit interface; other site 398527002554 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527002555 dimer interface [polypeptide binding]; other site 398527002556 conserved gate region; other site 398527002557 putative PBP binding loops; other site 398527002558 ABC-ATPase subunit interface; other site 398527002559 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 398527002560 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 398527002561 substrate binding pocket [chemical binding]; other site 398527002562 membrane-bound complex binding site; other site 398527002563 hinge residues; other site 398527002564 oxidase reductase; Provisional; Region: PTZ00273 398527002565 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 398527002566 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 398527002567 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 398527002568 FAD binding domain; Region: FAD_binding_4; pfam01565 398527002569 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 398527002570 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 398527002571 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 398527002572 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 398527002573 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 398527002574 dimer interface [polypeptide binding]; other site 398527002575 phosphorylation site [posttranslational modification] 398527002576 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527002577 ATP binding site [chemical binding]; other site 398527002578 Mg2+ binding site [ion binding]; other site 398527002579 G-X-G motif; other site 398527002580 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 398527002581 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527002582 active site 398527002583 phosphorylation site [posttranslational modification] 398527002584 intermolecular recognition site; other site 398527002585 dimerization interface [polypeptide binding]; other site 398527002586 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 398527002587 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527002588 active site 398527002589 phosphorylation site [posttranslational modification] 398527002590 intermolecular recognition site; other site 398527002591 dimerization interface [polypeptide binding]; other site 398527002592 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 398527002593 DNA binding residues [nucleotide binding] 398527002594 dimerization interface [polypeptide binding]; other site 398527002595 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 398527002596 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 398527002597 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 398527002598 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 398527002599 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 398527002600 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 398527002601 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 398527002602 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 398527002603 extended (e) SDRs; Region: SDR_e; cd08946 398527002604 NAD(P) binding site [chemical binding]; other site 398527002605 active site 398527002606 substrate binding site [chemical binding]; other site 398527002607 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527002608 D-galactonate transporter; Region: 2A0114; TIGR00893 398527002609 putative substrate translocation pore; other site 398527002610 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 398527002611 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 398527002612 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 398527002613 tartronate semialdehyde reductase; Provisional; Region: PRK15059 398527002614 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 398527002615 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 398527002616 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 398527002617 dimer interface [polypeptide binding]; other site 398527002618 NADP binding site [chemical binding]; other site 398527002619 catalytic residues [active] 398527002620 Transcriptional regulators [Transcription]; Region: FadR; COG2186 398527002621 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527002622 DNA-binding site [nucleotide binding]; DNA binding site 398527002623 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 398527002624 D-galactonate transporter; Region: 2A0114; TIGR00893 398527002625 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527002626 putative substrate translocation pore; other site 398527002627 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527002628 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 398527002629 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 398527002630 putative active site [active] 398527002631 catalytic residue [active] 398527002632 galactarate dehydratase; Region: galactar-dH20; TIGR03248 398527002633 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 398527002634 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 398527002635 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 398527002636 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 398527002637 NAD(P) binding site [chemical binding]; other site 398527002638 active site 398527002639 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 398527002640 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 398527002641 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 398527002642 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 398527002643 DctM-like transporters; Region: DctM; pfam06808 398527002644 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 398527002645 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 398527002646 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 398527002647 trimer interface [polypeptide binding]; other site 398527002648 eyelet of channel; other site 398527002649 4-oxalocrotonate tautomerase; Provisional; Region: PRK00745 398527002650 active site 1 [active] 398527002651 dimer interface [polypeptide binding]; other site 398527002652 hexamer interface [polypeptide binding]; other site 398527002653 active site 2 [active] 398527002654 aldolase II superfamily protein; Provisional; Region: PRK07044 398527002655 intersubunit interface [polypeptide binding]; other site 398527002656 active site 398527002657 Zn2+ binding site [ion binding]; other site 398527002658 Urea transporter; Region: UT; cl01829 398527002659 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 398527002660 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 398527002661 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 398527002662 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 398527002663 short chain dehydrogenase; Provisional; Region: PRK07832 398527002664 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 398527002665 NAD(P) binding site [chemical binding]; other site 398527002666 active site 398527002667 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 398527002668 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 398527002669 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 398527002670 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 398527002671 substrate binding pocket [chemical binding]; other site 398527002672 membrane-bound complex binding site; other site 398527002673 hinge residues; other site 398527002674 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg2; cd04778 398527002675 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 398527002676 DNA binding residues [nucleotide binding] 398527002677 putative dimer interface [polypeptide binding]; other site 398527002678 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 398527002679 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 398527002680 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 398527002681 Coenzyme A binding pocket [chemical binding]; other site 398527002682 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 398527002683 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 398527002684 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 398527002685 EamA-like transporter family; Region: EamA; pfam00892 398527002686 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 398527002687 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 398527002688 Major Facilitator Superfamily; Region: MFS_1; pfam07690 398527002689 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527002690 putative substrate translocation pore; other site 398527002691 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527002692 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 398527002693 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 398527002694 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 398527002695 hypothetical protein; Validated; Region: PRK08245 398527002696 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 398527002697 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527002698 active site 398527002699 phosphorylation site [posttranslational modification] 398527002700 intermolecular recognition site; other site 398527002701 dimerization interface [polypeptide binding]; other site 398527002702 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 398527002703 metal binding site 2 [ion binding]; metal-binding site 398527002704 putative DNA binding helix; other site 398527002705 metal binding site 1 [ion binding]; metal-binding site 398527002706 dimer interface [polypeptide binding]; other site 398527002707 structural Zn2+ binding site [ion binding]; other site 398527002708 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 398527002709 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 398527002710 putative C-terminal domain interface [polypeptide binding]; other site 398527002711 putative GSH binding site (G-site) [chemical binding]; other site 398527002712 putative dimer interface [polypeptide binding]; other site 398527002713 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 398527002714 putative N-terminal domain interface [polypeptide binding]; other site 398527002715 putative dimer interface [polypeptide binding]; other site 398527002716 putative substrate binding pocket (H-site) [chemical binding]; other site 398527002717 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 398527002718 Family description; Region: UvrD_C_2; pfam13538 398527002719 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 398527002720 active site 398527002721 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 398527002722 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 398527002723 dimer interface [polypeptide binding]; other site 398527002724 phosphorylation site [posttranslational modification] 398527002725 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 398527002726 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527002727 ATP binding site [chemical binding]; other site 398527002728 Mg2+ binding site [ion binding]; other site 398527002729 G-X-G motif; other site 398527002730 Response regulator receiver domain; Region: Response_reg; pfam00072 398527002731 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527002732 active site 398527002733 phosphorylation site [posttranslational modification] 398527002734 intermolecular recognition site; other site 398527002735 dimerization interface [polypeptide binding]; other site 398527002736 BetR domain; Region: BetR; pfam08667 398527002737 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527002738 active site 398527002739 phosphorylation site [posttranslational modification] 398527002740 intermolecular recognition site; other site 398527002741 HipA N-terminal domain; Region: Couple_hipA; pfam13657 398527002742 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 398527002743 HipA-like N-terminal domain; Region: HipA_N; pfam07805 398527002744 HipA-like C-terminal domain; Region: HipA_C; pfam07804 398527002745 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 398527002746 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 398527002747 non-specific DNA binding site [nucleotide binding]; other site 398527002748 salt bridge; other site 398527002749 sequence-specific DNA binding site [nucleotide binding]; other site 398527002750 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 398527002751 hydroxyglutarate oxidase; Provisional; Region: PRK11728 398527002752 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 398527002753 Ion channel; Region: Ion_trans_2; pfam07885 398527002754 TrkA-N domain; Region: TrkA_N; pfam02254 398527002755 ornithine cyclodeaminase; Validated; Region: PRK07340 398527002756 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 398527002757 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 398527002758 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 398527002759 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 398527002760 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 398527002761 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 398527002762 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 398527002763 type VI secretion lipoprotein, VC_A0113 family; Region: VI_chp_3; TIGR03352 398527002764 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 398527002765 TPR motif; other site 398527002766 binding surface 398527002767 Protein of unknown function (DUF770); Region: DUF770; pfam05591 398527002768 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 398527002769 Protein of unknown function (DUF877); Region: DUF877; pfam05943 398527002770 Protein of unknown function (DUF796); Region: DUF796; pfam05638 398527002771 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3518 398527002772 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 398527002773 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 398527002774 type VI secretion protein, VC_A0111 family; Region: VI_chp_1; TIGR03347 398527002775 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 398527002776 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527002777 Walker A motif; other site 398527002778 ATP binding site [chemical binding]; other site 398527002779 Walker B motif; other site 398527002780 arginine finger; other site 398527002781 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527002782 Walker A motif; other site 398527002783 ATP binding site [chemical binding]; other site 398527002784 Walker B motif; other site 398527002785 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 398527002786 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 398527002787 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 398527002788 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 398527002789 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 398527002790 ligand binding site [chemical binding]; other site 398527002791 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611 398527002792 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 398527002793 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 398527002794 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 398527002795 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 398527002796 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 398527002797 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 398527002798 active site 398527002799 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527002800 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527002801 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 398527002802 putative effector binding pocket; other site 398527002803 putative dimerization interface [polypeptide binding]; other site 398527002804 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 398527002805 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 398527002806 putative NAD(P) binding site [chemical binding]; other site 398527002807 putative substrate binding site [chemical binding]; other site 398527002808 catalytic Zn binding site [ion binding]; other site 398527002809 structural Zn binding site [ion binding]; other site 398527002810 dimer interface [polypeptide binding]; other site 398527002811 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 398527002812 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 398527002813 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527002814 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 398527002815 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 398527002816 Moco binding site; other site 398527002817 metal coordination site [ion binding]; other site 398527002818 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 398527002819 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 398527002820 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527002821 active site 398527002822 phosphorylation site [posttranslational modification] 398527002823 intermolecular recognition site; other site 398527002824 dimerization interface [polypeptide binding]; other site 398527002825 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 398527002826 DNA binding site [nucleotide binding] 398527002827 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 398527002828 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 398527002829 dimerization interface [polypeptide binding]; other site 398527002830 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 398527002831 dimer interface [polypeptide binding]; other site 398527002832 phosphorylation site [posttranslational modification] 398527002833 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527002834 ATP binding site [chemical binding]; other site 398527002835 Mg2+ binding site [ion binding]; other site 398527002836 G-X-G motif; other site 398527002837 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 398527002838 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 398527002839 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 398527002840 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 398527002841 PhnA protein; Region: PhnA; pfam03831 398527002842 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 398527002843 Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405 398527002844 PAS domain; Region: PAS_9; pfam13426 398527002845 PAS domain; Region: PAS_9; pfam13426 398527002846 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 398527002847 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 398527002848 metal binding site [ion binding]; metal-binding site 398527002849 active site 398527002850 I-site; other site 398527002851 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 398527002852 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 398527002853 putative ligand binding site [chemical binding]; other site 398527002854 NAD binding site [chemical binding]; other site 398527002855 catalytic site [active] 398527002856 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 398527002857 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 398527002858 molybdopterin cofactor binding site; other site 398527002859 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 398527002860 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 398527002861 The MopB_CT_2 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is...; Region: MopB_CT_2; cd02783 398527002862 putative molybdopterin cofactor binding site; other site 398527002863 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 398527002864 4Fe-4S binding domain; Region: Fer4; pfam00037 398527002865 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 398527002866 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 398527002867 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 398527002868 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 398527002869 active site 398527002870 dimer interface [polypeptide binding]; other site 398527002871 effector binding site; other site 398527002872 Domain of unknown function (DUF3331); Region: DUF3331; pfam11811 398527002873 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 398527002874 Putative esterase; Region: Esterase; pfam00756 398527002875 OpgC protein; Region: OpgC_C; pfam10129 398527002876 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 398527002877 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 398527002878 trimer interface [polypeptide binding]; other site 398527002879 eyelet of channel; other site 398527002880 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 398527002881 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 398527002882 dimer interface [polypeptide binding]; other site 398527002883 ADP-ribose binding site [chemical binding]; other site 398527002884 active site 398527002885 nudix motif; other site 398527002886 metal binding site [ion binding]; metal-binding site 398527002887 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 398527002888 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 398527002889 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 398527002890 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 398527002891 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 398527002892 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 398527002893 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 398527002894 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 398527002895 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 398527002896 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 398527002897 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 398527002898 Cytochrome c; Region: Cytochrom_C; pfam00034 398527002899 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 398527002900 hydrophobic ligand binding site; other site 398527002901 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 398527002902 Peptidase family M23; Region: Peptidase_M23; pfam01551 398527002903 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 398527002904 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 398527002905 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 398527002906 catalytic loop [active] 398527002907 iron binding site [ion binding]; other site 398527002908 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 398527002909 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 398527002910 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 398527002911 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 398527002912 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 398527002913 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 398527002914 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 398527002915 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 398527002916 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 398527002917 Cytochrome c; Region: Cytochrom_C; pfam00034 398527002918 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 398527002919 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527002920 dimer interface [polypeptide binding]; other site 398527002921 conserved gate region; other site 398527002922 putative PBP binding loops; other site 398527002923 ABC-ATPase subunit interface; other site 398527002924 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 398527002925 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527002926 dimer interface [polypeptide binding]; other site 398527002927 conserved gate region; other site 398527002928 putative PBP binding loops; other site 398527002929 ABC-ATPase subunit interface; other site 398527002930 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 398527002931 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 398527002932 substrate binding pocket [chemical binding]; other site 398527002933 membrane-bound complex binding site; other site 398527002934 hinge residues; other site 398527002935 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 398527002936 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 398527002937 Walker A/P-loop; other site 398527002938 ATP binding site [chemical binding]; other site 398527002939 Q-loop/lid; other site 398527002940 ABC transporter signature motif; other site 398527002941 Walker B; other site 398527002942 D-loop; other site 398527002943 H-loop/switch region; other site 398527002944 TOBE domain; Region: TOBE_2; pfam08402 398527002945 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 398527002946 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527002947 dimer interface [polypeptide binding]; other site 398527002948 conserved gate region; other site 398527002949 putative PBP binding loops; other site 398527002950 ABC-ATPase subunit interface; other site 398527002951 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 398527002952 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527002953 dimer interface [polypeptide binding]; other site 398527002954 conserved gate region; other site 398527002955 putative PBP binding loops; other site 398527002956 ABC-ATPase subunit interface; other site 398527002957 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 398527002958 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 398527002959 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 398527002960 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527002961 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 398527002962 substrate binding pocket [chemical binding]; other site 398527002963 dimerization interface [polypeptide binding]; other site 398527002964 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 398527002965 BON domain; Region: BON; pfam04972 398527002966 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 398527002967 active site 398527002968 DNA binding site [nucleotide binding] 398527002969 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 398527002970 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 398527002971 FOG: CBS domain [General function prediction only]; Region: COG0517 398527002972 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 398527002973 dimerization interface [polypeptide binding]; other site 398527002974 active site 398527002975 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 398527002976 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 398527002977 NAD(P) binding site [chemical binding]; other site 398527002978 active site 398527002979 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 398527002980 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527002981 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 398527002982 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 398527002983 Putative zinc-finger; Region: zf-HC2; pfam13490 398527002984 RNA polymerase sigma factor; Provisional; Region: PRK12511 398527002985 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 398527002986 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 398527002987 DNA binding residues [nucleotide binding] 398527002988 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 398527002989 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 398527002990 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 398527002991 putative heme binding pocket [chemical binding]; other site 398527002992 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 398527002993 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 398527002994 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 398527002995 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 398527002996 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 398527002997 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 398527002998 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 398527002999 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 398527003000 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 398527003001 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 398527003002 ATP binding site [chemical binding]; other site 398527003003 putative Mg++ binding site [ion binding]; other site 398527003004 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 398527003005 nucleotide binding region [chemical binding]; other site 398527003006 ATP-binding site [chemical binding]; other site 398527003007 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 398527003008 Peptidase family M23; Region: Peptidase_M23; pfam01551 398527003009 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 398527003010 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 398527003011 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 398527003012 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527003013 active site 398527003014 phosphorylation site [posttranslational modification] 398527003015 intermolecular recognition site; other site 398527003016 dimerization interface [polypeptide binding]; other site 398527003017 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 398527003018 DNA binding site [nucleotide binding] 398527003019 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4254 398527003020 FecR protein; Region: FecR; pfam04773 398527003021 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 398527003022 CHASE2 domain; Region: CHASE2; pfam05226 398527003023 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 398527003024 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 398527003025 dimer interface [polypeptide binding]; other site 398527003026 phosphorylation site [posttranslational modification] 398527003027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527003028 ATP binding site [chemical binding]; other site 398527003029 Mg2+ binding site [ion binding]; other site 398527003030 G-X-G motif; other site 398527003031 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 398527003032 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 398527003033 putative FMN binding site [chemical binding]; other site 398527003034 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 398527003035 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 398527003036 catalytic triad [active] 398527003037 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 398527003038 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 398527003039 homodimer interface [polypeptide binding]; other site 398527003040 Walker A motif; other site 398527003041 ATP binding site [chemical binding]; other site 398527003042 hydroxycobalamin binding site [chemical binding]; other site 398527003043 Walker B motif; other site 398527003044 cobalamin biosynthesis protein CbiG; Provisional; Region: PRK07027 398527003045 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 398527003046 active site 398527003047 SAM binding site [chemical binding]; other site 398527003048 homodimer interface [polypeptide binding]; other site 398527003049 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 398527003050 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 398527003051 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 398527003052 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 398527003053 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 398527003054 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 398527003055 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 398527003056 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527003057 Walker A motif; other site 398527003058 ATP binding site [chemical binding]; other site 398527003059 Walker B motif; other site 398527003060 arginine finger; other site 398527003061 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 398527003062 metal ion-dependent adhesion site (MIDAS); other site 398527003063 Flagellar protein YcgR; Region: YcgR_2; pfam12945 398527003064 PilZ domain; Region: PilZ; pfam07238 398527003065 Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143 398527003066 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 398527003067 FtsX-like permease family; Region: FtsX; pfam02687 398527003068 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 398527003069 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 398527003070 FtsX-like permease family; Region: FtsX; pfam02687 398527003071 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 398527003072 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 398527003073 Walker A/P-loop; other site 398527003074 ATP binding site [chemical binding]; other site 398527003075 Q-loop/lid; other site 398527003076 ABC transporter signature motif; other site 398527003077 Walker B; other site 398527003078 D-loop; other site 398527003079 H-loop/switch region; other site 398527003080 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 398527003081 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 398527003082 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 398527003083 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 398527003084 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 398527003085 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 398527003086 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 398527003087 D-pathway; other site 398527003088 Putative ubiquinol binding site [chemical binding]; other site 398527003089 Low-spin heme (heme b) binding site [chemical binding]; other site 398527003090 Putative water exit pathway; other site 398527003091 Binuclear center (heme o3/CuB) [ion binding]; other site 398527003092 K-pathway; other site 398527003093 Putative proton exit pathway; other site 398527003094 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 398527003095 Subunit I/III interface [polypeptide binding]; other site 398527003096 Subunit III/IV interface [polypeptide binding]; other site 398527003097 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 398527003098 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 398527003099 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 398527003100 active site 398527003101 HIGH motif; other site 398527003102 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 398527003103 active site 398527003104 KMSKS motif; other site 398527003105 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 398527003106 Uncharacterized conserved protein [Function unknown]; Region: COG2128 398527003107 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 398527003108 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 398527003109 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 398527003110 motif II; other site 398527003111 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 398527003112 Phosphoesterase family; Region: Phosphoesterase; pfam04185 398527003113 RNA polymerase sigma factor; Reviewed; Region: PRK05602 398527003114 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 398527003115 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 398527003116 Heavy-metal resistance; Region: Metal_resist; pfam13801 398527003117 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 398527003118 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 398527003119 Flavin Reductases; Region: FlaRed; cl00801 398527003120 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 398527003121 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 398527003122 active site 398527003123 non-prolyl cis peptide bond; other site 398527003124 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 398527003125 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 398527003126 non-specific DNA binding site [nucleotide binding]; other site 398527003127 salt bridge; other site 398527003128 sequence-specific DNA binding site [nucleotide binding]; other site 398527003129 BON domain; Region: BON; pfam04972 398527003130 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 398527003131 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 398527003132 active site 398527003133 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 398527003134 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 398527003135 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 398527003136 NAD(P) binding site [chemical binding]; other site 398527003137 active site 398527003138 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314 398527003139 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 398527003140 Putative long-chain fatty acid CoA ligase; Region: LC_FACS_like; cd05935 398527003141 acyl-activating enzyme (AAE) consensus motif; other site 398527003142 putative AMP binding site [chemical binding]; other site 398527003143 putative active site [active] 398527003144 putative CoA binding site [chemical binding]; other site 398527003145 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527003146 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527003147 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 398527003148 putative effector binding pocket; other site 398527003149 putative dimerization interface [polypeptide binding]; other site 398527003150 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 398527003151 tartrate dehydrogenase; Region: TTC; TIGR02089 398527003152 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 398527003153 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527003154 putative substrate translocation pore; other site 398527003155 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 398527003156 diiron binding motif [ion binding]; other site 398527003157 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 398527003158 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 398527003159 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 398527003160 Walker A/P-loop; other site 398527003161 ATP binding site [chemical binding]; other site 398527003162 Q-loop/lid; other site 398527003163 ABC transporter signature motif; other site 398527003164 Walker B; other site 398527003165 D-loop; other site 398527003166 H-loop/switch region; other site 398527003167 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 398527003168 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527003169 dimer interface [polypeptide binding]; other site 398527003170 conserved gate region; other site 398527003171 putative PBP binding loops; other site 398527003172 ABC-ATPase subunit interface; other site 398527003173 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 398527003174 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 398527003175 conserved cys residue [active] 398527003176 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 398527003177 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 398527003178 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 398527003179 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 398527003180 RHS Repeat; Region: RHS_repeat; pfam05593 398527003181 RHS Repeat; Region: RHS_repeat; pfam05593 398527003182 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 398527003183 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 398527003184 conserved cys residue [active] 398527003185 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 398527003186 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527003187 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 398527003188 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 398527003189 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 398527003190 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 398527003191 hydroxyglutarate oxidase; Provisional; Region: PRK11728 398527003192 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 398527003193 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 398527003194 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 398527003195 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 398527003196 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 398527003197 Sarcosine oxidase gamma subunit [Amino acid transport and metabolism]; Region: COG4583 398527003198 benzoate transport; Region: 2A0115; TIGR00895 398527003199 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527003200 putative substrate translocation pore; other site 398527003201 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527003202 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 398527003203 catalytic residue [active] 398527003204 Cupin domain; Region: Cupin_2; pfam07883 398527003205 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 398527003206 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 398527003207 choline dehydrogenase; Validated; Region: PRK02106 398527003208 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 398527003209 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 398527003210 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 398527003211 tetrameric interface [polypeptide binding]; other site 398527003212 NAD binding site [chemical binding]; other site 398527003213 catalytic residues [active] 398527003214 transcriptional regulator BetI; Validated; Region: PRK00767 398527003215 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 398527003216 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 398527003217 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 398527003218 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 398527003219 NAD binding site [chemical binding]; other site 398527003220 catalytic Zn binding site [ion binding]; other site 398527003221 structural Zn binding site [ion binding]; other site 398527003222 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 398527003223 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 398527003224 conserved cys residue [active] 398527003225 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527003226 serine hydroxymethyltransferase; Reviewed; Region: PRK13034 398527003227 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 398527003228 dimer interface [polypeptide binding]; other site 398527003229 active site 398527003230 glycine-pyridoxal phosphate binding site [chemical binding]; other site 398527003231 folate binding site [chemical binding]; other site 398527003232 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 398527003233 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 398527003234 active site 398527003235 dimer interface [polypeptide binding]; other site 398527003236 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 398527003237 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 398527003238 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 398527003239 putative active site [active] 398527003240 putative FMN binding site [chemical binding]; other site 398527003241 putative substrate binding site [chemical binding]; other site 398527003242 putative catalytic residue [active] 398527003243 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 398527003244 Domain of unknown function (DUF3483); Region: DUF3483; pfam11982 398527003245 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 398527003246 Cysteine-rich domain; Region: CCG; pfam02754 398527003247 Cysteine-rich domain; Region: CCG; pfam02754 398527003248 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 398527003249 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 398527003250 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 398527003251 Electron transfer flavoprotein domain; Region: ETF; pfam01012 398527003252 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 398527003253 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 398527003254 [2Fe-2S] cluster binding site [ion binding]; other site 398527003255 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 398527003256 putative alpha subunit interface [polypeptide binding]; other site 398527003257 putative active site [active] 398527003258 putative substrate binding site [chemical binding]; other site 398527003259 Fe binding site [ion binding]; other site 398527003260 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 398527003261 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 398527003262 FAD binding pocket [chemical binding]; other site 398527003263 FAD binding motif [chemical binding]; other site 398527003264 phosphate binding motif [ion binding]; other site 398527003265 beta-alpha-beta structure motif; other site 398527003266 NAD binding pocket [chemical binding]; other site 398527003267 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 398527003268 catalytic loop [active] 398527003269 iron binding site [ion binding]; other site 398527003270 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 398527003271 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 398527003272 formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011 398527003273 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 398527003274 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 398527003275 putative active site [active] 398527003276 putative substrate binding site [chemical binding]; other site 398527003277 putative cosubstrate binding site; other site 398527003278 catalytic site [active] 398527003279 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 398527003280 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527003281 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 398527003282 dimerization interface [polypeptide binding]; other site 398527003283 substrate binding pocket [chemical binding]; other site 398527003284 choline-sulfatase; Region: chol_sulfatase; TIGR03417 398527003285 Sulfatase; Region: Sulfatase; cl17466 398527003286 Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411 398527003287 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 398527003288 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 398527003289 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 398527003290 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 398527003291 trimer interface [polypeptide binding]; other site 398527003292 eyelet of channel; other site 398527003293 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527003294 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527003295 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 398527003296 putative effector binding pocket; other site 398527003297 dimerization interface [polypeptide binding]; other site 398527003298 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 398527003299 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 398527003300 putative C-terminal domain interface [polypeptide binding]; other site 398527003301 putative GSH binding site (G-site) [chemical binding]; other site 398527003302 putative dimer interface [polypeptide binding]; other site 398527003303 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 398527003304 putative N-terminal domain interface [polypeptide binding]; other site 398527003305 putative dimer interface [polypeptide binding]; other site 398527003306 putative substrate binding pocket (H-site) [chemical binding]; other site 398527003307 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 398527003308 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 398527003309 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 398527003310 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 398527003311 FAD binding pocket [chemical binding]; other site 398527003312 FAD binding motif [chemical binding]; other site 398527003313 phosphate binding motif [ion binding]; other site 398527003314 beta-alpha-beta structure motif; other site 398527003315 NAD binding pocket [chemical binding]; other site 398527003316 Heme binding pocket [chemical binding]; other site 398527003317 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 398527003318 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 398527003319 catalytic loop [active] 398527003320 iron binding site [ion binding]; other site 398527003321 Epoxide hydrolase N terminus; Region: EHN; pfam06441 398527003322 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 398527003323 Transcriptional regulators [Transcription]; Region: MarR; COG1846 398527003324 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 398527003325 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 398527003326 Coenzyme A binding pocket [chemical binding]; other site 398527003327 Cache domain; Region: Cache_1; pfam02743 398527003328 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 398527003329 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 398527003330 metal binding site [ion binding]; metal-binding site 398527003331 active site 398527003332 I-site; other site 398527003333 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 398527003334 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 398527003335 conserved cys residue [active] 398527003336 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527003337 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527003338 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 398527003339 Probable cobalt transporter subunit (CbtB); Region: CbtB; cl09723 398527003340 nitrile hydratase accessory protein; Region: nitrile_acc; TIGR03889 398527003341 Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979 398527003342 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 398527003343 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 398527003344 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 398527003345 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 398527003346 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 398527003347 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 398527003348 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 398527003349 Bacterial transcriptional activator domain; Region: BTAD; smart01043 398527003350 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 398527003351 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 398527003352 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 398527003353 Uncharacterized conserved protein [Function unknown]; Region: COG1262 398527003354 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 398527003355 Sulfatase; Region: Sulfatase; pfam00884 398527003356 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 398527003357 Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter hydrocarbonoclasticus isoprenoid Coenzyme A synthetase; Region: LC_FACS_bac; cd05932 398527003358 acyl-activating enzyme (AAE) consensus motif; other site 398527003359 putative AMP binding site [chemical binding]; other site 398527003360 putative active site [active] 398527003361 putative CoA binding site [chemical binding]; other site 398527003362 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 398527003363 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 398527003364 DNA binding residues [nucleotide binding] 398527003365 dimerization interface [polypeptide binding]; other site 398527003366 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 398527003367 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 398527003368 substrate binding site [chemical binding]; other site 398527003369 oxyanion hole (OAH) forming residues; other site 398527003370 trimer interface [polypeptide binding]; other site 398527003371 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 398527003372 lipid-transfer protein; Provisional; Region: PRK08256 398527003373 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 398527003374 active site 398527003375 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 398527003376 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 398527003377 active site 398527003378 lipid-transfer protein; Provisional; Region: PRK08256 398527003379 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 398527003380 active site 398527003381 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 398527003382 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 398527003383 FAD binding site [chemical binding]; other site 398527003384 substrate binding site [chemical binding]; other site 398527003385 catalytic base [active] 398527003386 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 398527003387 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 398527003388 active site 398527003389 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 398527003390 putative active site [active] 398527003391 putative catalytic site [active] 398527003392 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 398527003393 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 398527003394 NAD(P) binding site [chemical binding]; other site 398527003395 active site 398527003396 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 398527003397 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 398527003398 active site 398527003399 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 398527003400 CoA-transferase family III; Region: CoA_transf_3; pfam02515 398527003401 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 398527003402 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 398527003403 trimer interface [polypeptide binding]; other site 398527003404 eyelet of channel; other site 398527003405 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 398527003406 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 398527003407 NAD(P) binding site [chemical binding]; other site 398527003408 active site 398527003409 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 398527003410 glutathione-dependent formaldehyde-activating enzyme; Provisional; Region: PRK05417 398527003411 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 398527003412 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 398527003413 substrate binding site [chemical binding]; other site 398527003414 catalytic Zn binding site [ion binding]; other site 398527003415 NAD binding site [chemical binding]; other site 398527003416 structural Zn binding site [ion binding]; other site 398527003417 dimer interface [polypeptide binding]; other site 398527003418 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 398527003419 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 398527003420 hexamer interface [polypeptide binding]; other site 398527003421 ligand binding site [chemical binding]; other site 398527003422 putative active site [active] 398527003423 NAD(P) binding site [chemical binding]; other site 398527003424 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 398527003425 Glutaredoxin-like domain protein; Region: GlrX_arch; TIGR02187 398527003426 catalytic residue [active] 398527003427 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 398527003428 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527003429 metabolite-proton symporter; Region: 2A0106; TIGR00883 398527003430 putative substrate translocation pore; other site 398527003431 hypothetical protein; Provisional; Region: PRK07079 398527003432 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679 398527003433 metal binding site [ion binding]; metal-binding site 398527003434 putative dimer interface [polypeptide binding]; other site 398527003435 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527003436 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527003437 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 398527003438 dimerization interface [polypeptide binding]; other site 398527003439 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 398527003440 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 398527003441 FMN binding site [chemical binding]; other site 398527003442 active site 398527003443 substrate binding site [chemical binding]; other site 398527003444 catalytic residue [active] 398527003445 Uncharacterized conserved protein [Function unknown]; Region: COG2128 398527003446 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 398527003447 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527003448 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527003449 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 398527003450 putative effector binding pocket; other site 398527003451 dimerization interface [polypeptide binding]; other site 398527003452 Protein of unknown function (DUF1109); Region: DUF1109; pfam06532 398527003453 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 398527003454 hypothetical protein; Provisional; Region: PRK05409 398527003455 Predicted integral membrane protein [Function unknown]; Region: COG5572 398527003456 Protein of unknown function (DUF1109); Region: DUF1109; pfam06532 398527003457 RNA polymerase sigma factor; Provisional; Region: PRK12536 398527003458 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 398527003459 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 398527003460 DNA binding residues [nucleotide binding] 398527003461 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 398527003462 C-terminal domain interface [polypeptide binding]; other site 398527003463 GSH binding site (G-site) [chemical binding]; other site 398527003464 dimer interface [polypeptide binding]; other site 398527003465 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 398527003466 N-terminal domain interface [polypeptide binding]; other site 398527003467 dimer interface [polypeptide binding]; other site 398527003468 substrate binding pocket (H-site) [chemical binding]; other site 398527003469 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 398527003470 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 398527003471 Flagellin N-methylase; Region: FliB; pfam03692 398527003472 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 398527003473 catalytic residues [active] 398527003474 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 398527003475 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 398527003476 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 398527003477 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 398527003478 Zn2+ binding site [ion binding]; other site 398527003479 Mg2+ binding site [ion binding]; other site 398527003480 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 398527003481 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 398527003482 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 398527003483 DsbD alpha interface [polypeptide binding]; other site 398527003484 catalytic residues [active] 398527003485 Protein of unknown function (DUF1223); Region: DUF1223; pfam06764 398527003486 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 398527003487 putative catalytic residues [active] 398527003488 RNA polymerase sigma factor; Provisional; Region: PRK12536 398527003489 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 398527003490 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 398527003491 DNA binding residues [nucleotide binding] 398527003492 Protein of unknown function (DUF1109); Region: DUF1109; pfam06532 398527003493 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 398527003494 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 398527003495 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 398527003496 active site 398527003497 nucleophile elbow; other site 398527003498 Predicted membrane protein [Function unknown]; Region: COG2259 398527003499 Predicted integral membrane protein [Function unknown]; Region: COG5572 398527003500 Predicted membrane protein [Function unknown]; Region: COG2259 398527003501 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 398527003502 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 398527003503 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 398527003504 PAS domain; Region: PAS_9; pfam13426 398527003505 putative active site [active] 398527003506 heme pocket [chemical binding]; other site 398527003507 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 398527003508 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527003509 Walker A motif; other site 398527003510 ATP binding site [chemical binding]; other site 398527003511 Walker B motif; other site 398527003512 arginine finger; other site 398527003513 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 398527003514 Protein of unknown function, DUF485; Region: DUF485; pfam04341 398527003515 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 398527003516 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 398527003517 Na binding site [ion binding]; other site 398527003518 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 398527003519 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 398527003520 motif II; other site 398527003521 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 398527003522 putative catalytic residues [active] 398527003523 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 398527003524 EamA-like transporter family; Region: EamA; pfam00892 398527003525 EamA-like transporter family; Region: EamA; pfam00892 398527003526 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 398527003527 C-terminal domain interface [polypeptide binding]; other site 398527003528 GSH binding site (G-site) [chemical binding]; other site 398527003529 dimer interface [polypeptide binding]; other site 398527003530 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 398527003531 substrate binding pocket (H-site) [chemical binding]; other site 398527003532 N-terminal domain interface [polypeptide binding]; other site 398527003533 putative S-transferase; Provisional; Region: PRK11752 398527003534 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 398527003535 C-terminal domain interface [polypeptide binding]; other site 398527003536 GSH binding site (G-site) [chemical binding]; other site 398527003537 dimer interface [polypeptide binding]; other site 398527003538 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 398527003539 dimer interface [polypeptide binding]; other site 398527003540 N-terminal domain interface [polypeptide binding]; other site 398527003541 active site 398527003542 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 398527003543 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 398527003544 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 398527003545 metabolite-proton symporter; Region: 2A0106; TIGR00883 398527003546 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 398527003547 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 398527003548 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 398527003549 classical (c) SDRs; Region: SDR_c; cd05233 398527003550 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 398527003551 NAD(P) binding site [chemical binding]; other site 398527003552 active site 398527003553 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 398527003554 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527003555 putative substrate translocation pore; other site 398527003556 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527003557 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527003558 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 398527003559 dimerization interface [polypeptide binding]; other site 398527003560 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 398527003561 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 398527003562 tetramer interface [polypeptide binding]; other site 398527003563 active site 398527003564 Mg2+/Mn2+ binding site [ion binding]; other site 398527003565 benzoate transport; Region: 2A0115; TIGR00895 398527003566 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527003567 putative substrate translocation pore; other site 398527003568 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527003569 Transcriptional regulators [Transcription]; Region: GntR; COG1802 398527003570 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527003571 DNA-binding site [nucleotide binding]; DNA binding site 398527003572 FCD domain; Region: FCD; pfam07729 398527003573 DinB family; Region: DinB; cl17821 398527003574 DinB superfamily; Region: DinB_2; pfam12867 398527003575 Transcriptional regulators [Transcription]; Region: GntR; COG1802 398527003576 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527003577 DNA-binding site [nucleotide binding]; DNA binding site 398527003578 FCD domain; Region: FCD; pfam07729 398527003579 enoyl-CoA hydratase; Provisional; Region: PRK06494 398527003580 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 398527003581 substrate binding site [chemical binding]; other site 398527003582 trimer interface [polypeptide binding]; other site 398527003583 oxyanion hole (OAH) forming residues; other site 398527003584 benzoate transport; Region: 2A0115; TIGR00895 398527003585 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527003586 putative substrate translocation pore; other site 398527003587 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 398527003588 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 398527003589 NAD(P) binding site [chemical binding]; other site 398527003590 catalytic residues [active] 398527003591 Helix-turn-helix domain; Region: HTH_28; pfam13518 398527003592 Winged helix-turn helix; Region: HTH_29; pfam13551 398527003593 Homeodomain-like domain; Region: HTH_32; pfam13565 398527003594 Integrase core domain; Region: rve; pfam00665 398527003595 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4688 398527003596 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 398527003597 active site 398527003598 catalytic residues [active] 398527003599 DNA binding site [nucleotide binding] 398527003600 Int/Topo IB signature motif; other site 398527003601 Winged helix-turn helix; Region: HTH_29; pfam13551 398527003602 Integrase core domain; Region: rve; pfam00665 398527003603 AAA domain; Region: AAA_22; pfam13401 398527003604 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527003605 Walker A motif; other site 398527003606 ATP binding site [chemical binding]; other site 398527003607 Walker B motif; other site 398527003608 arginine finger; other site 398527003609 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 398527003610 active site 398527003611 Int/Topo IB signature motif; other site 398527003612 DNA binding site [nucleotide binding] 398527003613 Phosphoesterase family; Region: Phosphoesterase; pfam04185 398527003614 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 398527003615 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 398527003616 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 398527003617 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 398527003618 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 398527003619 TM-ABC transporter signature motif; other site 398527003620 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 398527003621 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 398527003622 Walker A/P-loop; other site 398527003623 ATP binding site [chemical binding]; other site 398527003624 Q-loop/lid; other site 398527003625 ABC transporter signature motif; other site 398527003626 Walker B; other site 398527003627 D-loop; other site 398527003628 H-loop/switch region; other site 398527003629 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 398527003630 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 398527003631 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 398527003632 ligand binding site [chemical binding]; other site 398527003633 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 398527003634 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 398527003635 TM-ABC transporter signature motif; other site 398527003636 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 398527003637 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 398527003638 substrate binding site [chemical binding]; other site 398527003639 dimer interface [polypeptide binding]; other site 398527003640 ATP binding site [chemical binding]; other site 398527003641 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 398527003642 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 398527003643 NAD(P) binding site [chemical binding]; other site 398527003644 catalytic residues [active] 398527003645 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 398527003646 NAD(P) binding site [chemical binding]; other site 398527003647 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 398527003648 intersubunit interface [polypeptide binding]; other site 398527003649 active site 398527003650 catalytic residue [active] 398527003651 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 398527003652 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 398527003653 Walker A/P-loop; other site 398527003654 ATP binding site [chemical binding]; other site 398527003655 Q-loop/lid; other site 398527003656 ABC transporter signature motif; other site 398527003657 Walker B; other site 398527003658 D-loop; other site 398527003659 H-loop/switch region; other site 398527003660 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 398527003661 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 398527003662 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 398527003663 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 398527003664 TM-ABC transporter signature motif; other site 398527003665 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_7; cd06316 398527003666 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 398527003667 putative ligand binding site [chemical binding]; other site 398527003668 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 398527003669 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 398527003670 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 398527003671 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 398527003672 HlyD family secretion protein; Region: HlyD_3; pfam13437 398527003673 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 398527003674 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 398527003675 putative DNA binding site [nucleotide binding]; other site 398527003676 dimerization interface [polypeptide binding]; other site 398527003677 putative Zn2+ binding site [ion binding]; other site 398527003678 Homeodomain-like domain; Region: HTH_23; pfam13384 398527003679 Domain of Unknown Function (DUF1521); Region: DUF1521; pfam07481 398527003680 Flagellar biosynthesis/type III secretory pathway ATPase [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliI; COG1157 398527003681 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 398527003682 Walker A motif; other site 398527003683 ATP binding site [chemical binding]; other site 398527003684 Walker B motif; other site 398527003685 FHIPEP family; Region: FHIPEP; pfam00771 398527003686 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 398527003687 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 398527003688 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 398527003689 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 398527003690 type III secretion protein, HrpO family; Region: fliQ_rel_III; TIGR01403 398527003691 type III secretion system protein YscR; Provisional; Region: PRK12797 398527003692 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 398527003693 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 398527003694 Flagellar assembly protein FliH; Region: FliH; pfam02108 398527003695 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 398527003696 type III secretion outer membrane pore, YscC/HrcC family; Region: type_III_yscC; TIGR02516 398527003697 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 398527003698 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 398527003699 Ribbon-helix-helix domain; Region: RHH_4; pfam13467 398527003700 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 398527003701 HAMP domain; Region: HAMP; pfam00672 398527003702 dimerization interface [polypeptide binding]; other site 398527003703 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 398527003704 dimer interface [polypeptide binding]; other site 398527003705 phosphorylation site [posttranslational modification] 398527003706 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527003707 ATP binding site [chemical binding]; other site 398527003708 Mg2+ binding site [ion binding]; other site 398527003709 G-X-G motif; other site 398527003710 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 398527003711 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527003712 active site 398527003713 phosphorylation site [posttranslational modification] 398527003714 intermolecular recognition site; other site 398527003715 dimerization interface [polypeptide binding]; other site 398527003716 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 398527003717 DNA binding site [nucleotide binding] 398527003718 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 398527003719 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 398527003720 Walker A/P-loop; other site 398527003721 ATP binding site [chemical binding]; other site 398527003722 Q-loop/lid; other site 398527003723 ABC transporter signature motif; other site 398527003724 Walker B; other site 398527003725 D-loop; other site 398527003726 H-loop/switch region; other site 398527003727 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 398527003728 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527003729 dimer interface [polypeptide binding]; other site 398527003730 conserved gate region; other site 398527003731 putative PBP binding loops; other site 398527003732 ABC-ATPase subunit interface; other site 398527003733 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 398527003734 Amidase; Region: Amidase; cl11426 398527003735 urea carboxylase; Region: urea_carbox; TIGR02712 398527003736 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 398527003737 ATP-grasp domain; Region: ATP-grasp_4; cl17255 398527003738 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 398527003739 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 398527003740 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 398527003741 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 398527003742 carboxyltransferase (CT) interaction site; other site 398527003743 biotinylation site [posttranslational modification]; other site 398527003744 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 398527003745 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 398527003746 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 398527003747 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 398527003748 oxidase reductase; Provisional; Region: PTZ00273 398527003749 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 398527003750 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 398527003751 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 398527003752 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 398527003753 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 398527003754 rod shape-determining protein MreB; Provisional; Region: PRK13927 398527003755 MreB and similar proteins; Region: MreB_like; cd10225 398527003756 nucleotide binding site [chemical binding]; other site 398527003757 Mg binding site [ion binding]; other site 398527003758 putative protofilament interaction site [polypeptide binding]; other site 398527003759 RodZ interaction site [polypeptide binding]; other site 398527003760 Transcriptional regulators [Transcription]; Region: FadR; COG2186 398527003761 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527003762 DNA-binding site [nucleotide binding]; DNA binding site 398527003763 FCD domain; Region: FCD; pfam07729 398527003764 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 398527003765 Isochorismatase family; Region: Isochorismatase; pfam00857 398527003766 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 398527003767 catalytic triad [active] 398527003768 conserved cis-peptide bond; other site 398527003769 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 398527003770 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 398527003771 Walker A/P-loop; other site 398527003772 ATP binding site [chemical binding]; other site 398527003773 Q-loop/lid; other site 398527003774 ABC transporter signature motif; other site 398527003775 Walker B; other site 398527003776 D-loop; other site 398527003777 H-loop/switch region; other site 398527003778 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 398527003779 Isochorismatase family; Region: Isochorismatase; pfam00857 398527003780 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 398527003781 catalytic triad [active] 398527003782 conserved cis-peptide bond; other site 398527003783 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 398527003784 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 398527003785 TM-ABC transporter signature motif; other site 398527003786 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 398527003787 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 398527003788 TM-ABC transporter signature motif; other site 398527003789 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 398527003790 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 398527003791 putative ligand binding site [chemical binding]; other site 398527003792 allophanate hydrolase; Provisional; Region: PRK08186 398527003793 Amidase; Region: Amidase; cl11426 398527003794 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 398527003795 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 398527003796 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 398527003797 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 398527003798 TM-ABC transporter signature motif; other site 398527003799 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 398527003800 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 398527003801 TM-ABC transporter signature motif; other site 398527003802 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 398527003803 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 398527003804 Walker A/P-loop; other site 398527003805 ATP binding site [chemical binding]; other site 398527003806 Q-loop/lid; other site 398527003807 ABC transporter signature motif; other site 398527003808 Walker B; other site 398527003809 D-loop; other site 398527003810 H-loop/switch region; other site 398527003811 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 398527003812 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 398527003813 Periplasmic binding component of a family of basic membrane lipoproteins from Borrelia and various putative lipoproteins from other bacteria; Region: PBP1_BmpA_like; cd06304 398527003814 ligand binding site [chemical binding]; other site 398527003815 Isochorismatase family; Region: Isochorismatase; pfam00857 398527003816 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 398527003817 catalytic triad [active] 398527003818 conserved cis-peptide bond; other site 398527003819 Amidase; Region: Amidase; cl11426 398527003820 indole-3-acetamide amidohydrolase; Region: PLN02722 398527003821 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 398527003822 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 398527003823 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 398527003824 Transcriptional regulators [Transcription]; Region: GntR; COG1802 398527003825 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527003826 DNA-binding site [nucleotide binding]; DNA binding site 398527003827 FCD domain; Region: FCD; pfam07729 398527003828 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases; Region: CE4_PuuE_like; cd10979 398527003829 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 398527003830 putative active site [active] 398527003831 putative catalytic site [active] 398527003832 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 398527003833 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 398527003834 Walker A/P-loop; other site 398527003835 ATP binding site [chemical binding]; other site 398527003836 Q-loop/lid; other site 398527003837 ABC transporter signature motif; other site 398527003838 Walker B; other site 398527003839 D-loop; other site 398527003840 H-loop/switch region; other site 398527003841 TOBE domain; Region: TOBE_2; pfam08402 398527003842 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 398527003843 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 398527003844 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527003845 dimer interface [polypeptide binding]; other site 398527003846 conserved gate region; other site 398527003847 putative PBP binding loops; other site 398527003848 ABC-ATPase subunit interface; other site 398527003849 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 398527003850 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527003851 dimer interface [polypeptide binding]; other site 398527003852 conserved gate region; other site 398527003853 putative PBP binding loops; other site 398527003854 ABC-ATPase subunit interface; other site 398527003855 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 398527003856 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 398527003857 Flavin binding site [chemical binding]; other site 398527003858 Esterase/lipase [General function prediction only]; Region: COG1647 398527003859 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 398527003860 hypothetical protein; Provisional; Region: PRK11239 398527003861 Protein of unknown function, DUF480; Region: DUF480; pfam04337 398527003862 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 398527003863 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 398527003864 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 398527003865 sequence-specific DNA binding site [nucleotide binding]; other site 398527003866 salt bridge; other site 398527003867 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 398527003868 Coenzyme A binding pocket [chemical binding]; other site 398527003869 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 398527003870 CoenzymeA binding site [chemical binding]; other site 398527003871 subunit interaction site [polypeptide binding]; other site 398527003872 PHB binding site; other site 398527003873 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 398527003874 BON domain; Region: BON; pfam04972 398527003875 propionate/acetate kinase; Provisional; Region: PRK12379 398527003876 Acetokinase family; Region: Acetate_kinase; cl17229 398527003877 putative phosphoketolase; Provisional; Region: PRK05261 398527003878 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 398527003879 TPP-binding site; other site 398527003880 XFP C-terminal domain; Region: XFP_C; pfam09363 398527003881 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 398527003882 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 398527003883 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 398527003884 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 398527003885 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 398527003886 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 398527003887 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527003888 Major Facilitator Superfamily; Region: MFS_1; pfam07690 398527003889 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 398527003890 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 398527003891 catalytic residues [active] 398527003892 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 398527003893 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 398527003894 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 398527003895 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 398527003896 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 398527003897 dimer interface [polypeptide binding]; other site 398527003898 phosphorylation site [posttranslational modification] 398527003899 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527003900 ATP binding site [chemical binding]; other site 398527003901 Mg2+ binding site [ion binding]; other site 398527003902 G-X-G motif; other site 398527003903 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527003904 Response regulator receiver domain; Region: Response_reg; pfam00072 398527003905 active site 398527003906 phosphorylation site [posttranslational modification] 398527003907 intermolecular recognition site; other site 398527003908 dimerization interface [polypeptide binding]; other site 398527003909 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 398527003910 iron-sulfur cluster [ion binding]; other site 398527003911 [2Fe-2S] cluster binding site [ion binding]; other site 398527003912 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 398527003913 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 398527003914 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 398527003915 Domain of unknown function DUF20; Region: UPF0118; pfam01594 398527003916 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 398527003917 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 398527003918 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 398527003919 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 398527003920 active site 398527003921 catalytic site [active] 398527003922 PRC-barrel domain; Region: PRC; pfam05239 398527003923 Response regulator receiver domain; Region: Response_reg; pfam00072 398527003924 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527003925 active site 398527003926 phosphorylation site [posttranslational modification] 398527003927 intermolecular recognition site; other site 398527003928 dimerization interface [polypeptide binding]; other site 398527003929 ATP-dependent DNA ligase; Validated; Region: PRK09247 398527003930 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 398527003931 active site 398527003932 DNA binding site [nucleotide binding] 398527003933 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 398527003934 DNA binding site [nucleotide binding] 398527003935 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 398527003936 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 398527003937 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 398527003938 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 398527003939 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 398527003940 catalytic site [active] 398527003941 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 398527003942 PAS domain; Region: PAS_9; pfam13426 398527003943 putative active site [active] 398527003944 heme pocket [chemical binding]; other site 398527003945 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 398527003946 PAS fold; Region: PAS_3; pfam08447 398527003947 putative active site [active] 398527003948 heme pocket [chemical binding]; other site 398527003949 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 398527003950 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 398527003951 putative active site [active] 398527003952 heme pocket [chemical binding]; other site 398527003953 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 398527003954 dimer interface [polypeptide binding]; other site 398527003955 phosphorylation site [posttranslational modification] 398527003956 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527003957 ATP binding site [chemical binding]; other site 398527003958 Mg2+ binding site [ion binding]; other site 398527003959 G-X-G motif; other site 398527003960 Response regulator receiver domain; Region: Response_reg; pfam00072 398527003961 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527003962 active site 398527003963 phosphorylation site [posttranslational modification] 398527003964 intermolecular recognition site; other site 398527003965 dimerization interface [polypeptide binding]; other site 398527003966 Predicted ATPase [General function prediction only]; Region: COG1485 398527003967 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 398527003968 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 398527003969 TPP-binding site [chemical binding]; other site 398527003970 dimer interface [polypeptide binding]; other site 398527003971 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 398527003972 PYR/PP interface [polypeptide binding]; other site 398527003973 dimer interface [polypeptide binding]; other site 398527003974 TPP binding site [chemical binding]; other site 398527003975 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 398527003976 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 398527003977 anti-TRAP (AT) protein specific to Bacilli; Region: anti-TRAP; cd10748 398527003978 TRAP binding interface [polypeptide binding]; other site 398527003979 Zn binding site [ion binding]; other site 398527003980 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 398527003981 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 398527003982 putative molybdopterin cofactor binding site [chemical binding]; other site 398527003983 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 398527003984 putative molybdopterin cofactor binding site; other site 398527003985 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 398527003986 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 398527003987 trimer interface [polypeptide binding]; other site 398527003988 eyelet of channel; other site 398527003989 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 398527003990 Walker A motif; other site 398527003991 ATP binding site [chemical binding]; other site 398527003992 Walker B motif; other site 398527003993 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 398527003994 metal ion-dependent adhesion site (MIDAS); other site 398527003995 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 398527003996 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 398527003997 putative active site [active] 398527003998 putative dimer interface [polypeptide binding]; other site 398527003999 MarC family integral membrane protein; Region: MarC; cl00919 398527004000 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 398527004001 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 398527004002 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 398527004003 Na binding site [ion binding]; other site 398527004004 glycogen synthase; Provisional; Region: glgA; PRK00654 398527004005 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 398527004006 ADP-binding pocket [chemical binding]; other site 398527004007 homodimer interface [polypeptide binding]; other site 398527004008 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 398527004009 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 398527004010 active site 398527004011 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 398527004012 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 398527004013 C-terminal domain interface [polypeptide binding]; other site 398527004014 GSH binding site (G-site) [chemical binding]; other site 398527004015 dimer interface [polypeptide binding]; other site 398527004016 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 398527004017 N-terminal domain interface [polypeptide binding]; other site 398527004018 dimer interface [polypeptide binding]; other site 398527004019 substrate binding pocket (H-site) [chemical binding]; other site 398527004020 Phytochelatin synthase; Region: Phytochelatin; pfam05023 398527004021 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 398527004022 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 398527004023 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 398527004024 metal binding site [ion binding]; metal-binding site 398527004025 active site 398527004026 I-site; other site 398527004027 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 398527004028 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 398527004029 FMN binding site [chemical binding]; other site 398527004030 active site 398527004031 substrate binding site [chemical binding]; other site 398527004032 catalytic residue [active] 398527004033 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 398527004034 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 398527004035 putative NAD(P) binding site [chemical binding]; other site 398527004036 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527004037 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527004038 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 398527004039 putative effector binding pocket; other site 398527004040 dimerization interface [polypeptide binding]; other site 398527004041 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 398527004042 putative catalytic residues [active] 398527004043 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 398527004044 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 398527004045 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 398527004046 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 398527004047 active site 398527004048 metal binding site [ion binding]; metal-binding site 398527004049 short chain dehydrogenase; Provisional; Region: PRK06172 398527004050 classical (c) SDRs; Region: SDR_c; cd05233 398527004051 NAD(P) binding site [chemical binding]; other site 398527004052 active site 398527004053 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 398527004054 GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051 398527004055 putative C-terminal domain interface [polypeptide binding]; other site 398527004056 putative GSH binding site (G-site) [chemical binding]; other site 398527004057 putative dimer interface [polypeptide binding]; other site 398527004058 C-terminal, alpha helical domain of GTT2-like Glutathione S-transferases; Region: GST_C_GTT2_like; cd03182 398527004059 putative N-terminal domain interface [polypeptide binding]; other site 398527004060 putative dimer interface [polypeptide binding]; other site 398527004061 putative substrate binding pocket (H-site) [chemical binding]; other site 398527004062 Peptidase family M1; Region: Peptidase_M1; pfam01433 398527004063 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 398527004064 Zn binding site [ion binding]; other site 398527004065 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 398527004066 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 398527004067 active site 398527004068 catalytic tetrad [active] 398527004069 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 398527004070 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 398527004071 C-terminal domain interface [polypeptide binding]; other site 398527004072 GSH binding site (G-site) [chemical binding]; other site 398527004073 dimer interface [polypeptide binding]; other site 398527004074 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 398527004075 N-terminal domain interface [polypeptide binding]; other site 398527004076 dimer interface [polypeptide binding]; other site 398527004077 substrate binding pocket (H-site) [chemical binding]; other site 398527004078 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 398527004079 putative hydrophobic ligand binding site [chemical binding]; other site 398527004080 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 398527004081 dimerization interface [polypeptide binding]; other site 398527004082 putative DNA binding site [nucleotide binding]; other site 398527004083 putative Zn2+ binding site [ion binding]; other site 398527004084 transcriptional regulator; Provisional; Region: PRK10632 398527004085 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527004086 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 398527004087 putative effector binding pocket; other site 398527004088 putative dimerization interface [polypeptide binding]; other site 398527004089 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 398527004090 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 398527004091 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 398527004092 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 398527004093 dimerization interface [polypeptide binding]; other site 398527004094 ligand binding site [chemical binding]; other site 398527004095 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 398527004096 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527004097 DNA-binding site [nucleotide binding]; DNA binding site 398527004098 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 398527004099 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 398527004100 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527004101 homodimer interface [polypeptide binding]; other site 398527004102 catalytic residue [active] 398527004103 TIGR03118 family protein; Region: PEPCTERM_chp_1 398527004104 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 398527004105 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527004106 Walker A motif; other site 398527004107 ATP binding site [chemical binding]; other site 398527004108 Walker B motif; other site 398527004109 arginine finger; other site 398527004110 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 398527004111 Epoxide hydrolase N terminus; Region: EHN; pfam06441 398527004112 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 398527004113 LrgA family; Region: LrgA; pfam03788 398527004114 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 398527004115 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 398527004116 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971 398527004117 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 398527004118 EamA-like transporter family; Region: EamA; pfam00892 398527004119 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 398527004120 Trehalase; Region: Trehalase; cl17346 398527004121 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 398527004122 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 398527004123 active site clefts [active] 398527004124 zinc binding site [ion binding]; other site 398527004125 dimer interface [polypeptide binding]; other site 398527004126 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 398527004127 active site clefts [active] 398527004128 zinc binding site [ion binding]; other site 398527004129 dimer interface [polypeptide binding]; other site 398527004130 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 398527004131 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 398527004132 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 398527004133 trimer interface [polypeptide binding]; other site 398527004134 eyelet of channel; other site 398527004135 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 398527004136 Major Facilitator Superfamily; Region: MFS_1; pfam07690 398527004137 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527004138 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527004139 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 398527004140 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 398527004141 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527004142 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 398527004143 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 398527004144 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527004145 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 398527004146 dimerization interface [polypeptide binding]; other site 398527004147 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 398527004148 agmatinase; Region: agmatinase; TIGR01230 398527004149 oligomer interface [polypeptide binding]; other site 398527004150 putative active site [active] 398527004151 Mn binding site [ion binding]; other site 398527004152 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 398527004153 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 398527004154 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 398527004155 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527004156 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 398527004157 putative dimerization interface [polypeptide binding]; other site 398527004158 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 398527004159 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 398527004160 THF binding site; other site 398527004161 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 398527004162 substrate binding site [chemical binding]; other site 398527004163 THF binding site; other site 398527004164 zinc-binding site [ion binding]; other site 398527004165 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 398527004166 active site 398527004167 SAM binding site [chemical binding]; other site 398527004168 homodimer interface [polypeptide binding]; other site 398527004169 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 398527004170 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 398527004171 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 398527004172 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 398527004173 active site 398527004174 putative homodimer interface [polypeptide binding]; other site 398527004175 SAM binding site [chemical binding]; other site 398527004176 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 398527004177 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 398527004178 S-adenosylmethionine binding site [chemical binding]; other site 398527004179 precorrin-3B synthase; Region: CobG; TIGR02435 398527004180 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 398527004181 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 398527004182 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 398527004183 Precorrin-8X methylmutase; Region: CbiC; pfam02570 398527004184 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 398527004185 active site 398527004186 SAM binding site [chemical binding]; other site 398527004187 homodimer interface [polypeptide binding]; other site 398527004188 Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073 398527004189 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 398527004190 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 398527004191 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 398527004192 active site 398527004193 SAM binding site [chemical binding]; other site 398527004194 homodimer interface [polypeptide binding]; other site 398527004195 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 398527004196 Protein of unknown function (DUF796); Region: DUF796; pfam05638 398527004197 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 398527004198 AAA domain; Region: AAA_23; pfam13476 398527004199 Walker A/P-loop; other site 398527004200 ATP binding site [chemical binding]; other site 398527004201 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 398527004202 active site 398527004203 metal binding site [ion binding]; metal-binding site 398527004204 DNA binding site [nucleotide binding] 398527004205 Predicted membrane protein [Function unknown]; Region: COG2733 398527004206 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 398527004207 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 398527004208 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 398527004209 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 398527004210 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 398527004211 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 398527004212 aldolase II superfamily protein; Provisional; Region: PRK07044 398527004213 intersubunit interface [polypeptide binding]; other site 398527004214 active site 398527004215 Zn2+ binding site [ion binding]; other site 398527004216 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 398527004217 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 398527004218 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527004219 homodimer interface [polypeptide binding]; other site 398527004220 catalytic residue [active] 398527004221 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527004222 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527004223 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 398527004224 putative dimerization interface [polypeptide binding]; other site 398527004225 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 398527004226 DNA binding residues [nucleotide binding] 398527004227 dimerization interface [polypeptide binding]; other site 398527004228 Response regulator receiver domain; Region: Response_reg; pfam00072 398527004229 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527004230 active site 398527004231 phosphorylation site [posttranslational modification] 398527004232 intermolecular recognition site; other site 398527004233 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 398527004234 dimerization interface [polypeptide binding]; other site 398527004235 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 398527004236 dimer interface [polypeptide binding]; other site 398527004237 phosphorylation site [posttranslational modification] 398527004238 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527004239 ATP binding site [chemical binding]; other site 398527004240 Mg2+ binding site [ion binding]; other site 398527004241 G-X-G motif; other site 398527004242 CheB methylesterase; Region: CheB_methylest; pfam01339 398527004243 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 398527004244 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 398527004245 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 398527004246 CHASE3 domain; Region: CHASE3; pfam05227 398527004247 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 398527004248 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 398527004249 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 398527004250 dimer interface [polypeptide binding]; other site 398527004251 phosphorylation site [posttranslational modification] 398527004252 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527004253 ATP binding site [chemical binding]; other site 398527004254 Mg2+ binding site [ion binding]; other site 398527004255 G-X-G motif; other site 398527004256 Response regulator receiver domain; Region: Response_reg; pfam00072 398527004257 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527004258 active site 398527004259 phosphorylation site [posttranslational modification] 398527004260 intermolecular recognition site; other site 398527004261 dimerization interface [polypeptide binding]; other site 398527004262 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 398527004263 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527004264 active site 398527004265 phosphorylation site [posttranslational modification] 398527004266 intermolecular recognition site; other site 398527004267 dimerization interface [polypeptide binding]; other site 398527004268 Response regulator receiver domain; Region: Response_reg; pfam00072 398527004269 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527004270 active site 398527004271 phosphorylation site [posttranslational modification] 398527004272 intermolecular recognition site; other site 398527004273 dimerization interface [polypeptide binding]; other site 398527004274 hydroperoxidase II; Provisional; Region: katE; PRK11249 398527004275 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 398527004276 tetramer interface [polypeptide binding]; other site 398527004277 heme binding pocket [chemical binding]; other site 398527004278 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 398527004279 domain interactions; other site 398527004280 MltA-interacting protein MipA; Region: MipA; cl01504 398527004281 methionine sulfoxide reductase A; Provisional; Region: PRK13014 398527004282 methionine sulfoxide reductase B; Provisional; Region: PRK00222 398527004283 SelR domain; Region: SelR; pfam01641 398527004284 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 398527004285 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 398527004286 putative DNA binding site [nucleotide binding]; other site 398527004287 putative Zn2+ binding site [ion binding]; other site 398527004288 AsnC family; Region: AsnC_trans_reg; pfam01037 398527004289 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 398527004290 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 398527004291 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527004292 catalytic residue [active] 398527004293 LysR family transcriptional regulator; Provisional; Region: PRK14997 398527004294 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527004295 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 398527004296 putative effector binding pocket; other site 398527004297 dimerization interface [polypeptide binding]; other site 398527004298 Pirin-related protein [General function prediction only]; Region: COG1741 398527004299 Pirin; Region: Pirin; pfam02678 398527004300 Predicted membrane protein [Function unknown]; Region: COG2259 398527004301 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 398527004302 Fatty acid desaturase; Region: FA_desaturase; pfam00487 398527004303 Di-iron ligands [ion binding]; other site 398527004304 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 398527004305 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 398527004306 catalytic residue [active] 398527004307 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 398527004308 catalytic residues [active] 398527004309 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 398527004310 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 398527004311 peroxiredoxin; Region: AhpC; TIGR03137 398527004312 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 398527004313 dimer interface [polypeptide binding]; other site 398527004314 decamer (pentamer of dimers) interface [polypeptide binding]; other site 398527004315 catalytic triad [active] 398527004316 peroxidatic and resolving cysteines [active] 398527004317 Propionate catabolism activator; Region: PrpR_N; pfam06506 398527004318 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 398527004319 PAS domain; Region: PAS; smart00091 398527004320 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527004321 Walker A motif; other site 398527004322 ATP binding site [chemical binding]; other site 398527004323 Walker B motif; other site 398527004324 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 398527004325 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 398527004326 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 398527004327 tetramer interface [polypeptide binding]; other site 398527004328 active site 398527004329 Mg2+/Mn2+ binding site [ion binding]; other site 398527004330 putative transporter; Provisional; Region: PRK10504 398527004331 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527004332 putative substrate translocation pore; other site 398527004333 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 398527004334 Coenzyme A binding pocket [chemical binding]; other site 398527004335 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 398527004336 Cation efflux family; Region: Cation_efflux; cl00316 398527004337 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 398527004338 SnoaL-like domain; Region: SnoaL_2; pfam12680 398527004339 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527004340 Major Facilitator Superfamily; Region: MFS_1; pfam07690 398527004341 putative substrate translocation pore; other site 398527004342 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527004343 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527004344 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527004345 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 398527004346 dimerization interface [polypeptide binding]; other site 398527004347 substrate binding pocket [chemical binding]; other site 398527004348 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 398527004349 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 398527004350 active site 398527004351 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 398527004352 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 398527004353 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 398527004354 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 398527004355 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 398527004356 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527004357 Walker A motif; other site 398527004358 ATP binding site [chemical binding]; other site 398527004359 Walker B motif; other site 398527004360 arginine finger; other site 398527004361 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 398527004362 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527004363 putative substrate translocation pore; other site 398527004364 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527004365 NIPSNAP; Region: NIPSNAP; pfam07978 398527004366 Mechanosensitive ion channel; Region: MS_channel; pfam00924 398527004367 DEAD/DEAH box helicase; Region: DEAD; pfam00270 398527004368 ATP binding site [chemical binding]; other site 398527004369 DEAD_2; Region: DEAD_2; pfam06733 398527004370 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 398527004371 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 398527004372 This model contains proteins with the VRR-NUC domain; Region: VRR_NUC; smart00990 398527004373 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 398527004374 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527004375 D-galactonate transporter; Region: 2A0114; TIGR00893 398527004376 ectoine utilization protein EutE; Region: ectoine_eutE; TIGR02994 398527004377 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_2; cd06252 398527004378 putative active site [active] 398527004379 Zn binding site [ion binding]; other site 398527004380 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527004381 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527004382 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 398527004383 dimerization interface [polypeptide binding]; other site 398527004384 substrate binding pocket [chemical binding]; other site 398527004385 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 398527004386 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 398527004387 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 398527004388 4Fe-4S binding domain; Region: Fer4; pfam00037 398527004389 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 398527004390 Cysteine-rich domain; Region: CCG; pfam02754 398527004391 Cysteine-rich domain; Region: CCG; pfam02754 398527004392 HipA N-terminal domain; Region: Couple_hipA; pfam13657 398527004393 HipA-like N-terminal domain; Region: HipA_N; pfam07805 398527004394 HipA-like C-terminal domain; Region: HipA_C; pfam07804 398527004395 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 398527004396 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 398527004397 non-specific DNA binding site [nucleotide binding]; other site 398527004398 salt bridge; other site 398527004399 sequence-specific DNA binding site [nucleotide binding]; other site 398527004400 Transcriptional regulators [Transcription]; Region: FadR; COG2186 398527004401 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527004402 DNA-binding site [nucleotide binding]; DNA binding site 398527004403 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 398527004404 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 398527004405 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 398527004406 aspartate aminotransferase; Provisional; Region: PRK05764 398527004407 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 398527004408 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527004409 homodimer interface [polypeptide binding]; other site 398527004410 catalytic residue [active] 398527004411 RNA polymerase factor sigma-54; Provisional; Region: PRK12469 398527004412 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 398527004413 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 398527004414 periplasmic protein; Provisional; Region: PRK10568 398527004415 Domain of unknown function (DUF2383); Region: DUF2383; cl17556 398527004416 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 398527004417 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 398527004418 intracellular protease, PfpI family; Region: PfpI; TIGR01382 398527004419 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 398527004420 proposed catalytic triad [active] 398527004421 conserved cys residue [active] 398527004422 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 398527004423 DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659 398527004424 active site 398527004425 DNA binding site [nucleotide binding] 398527004426 Int/Topo IB signature motif; other site 398527004427 catalytic residues [active] 398527004428 PRC-barrel domain; Region: PRC; pfam05239 398527004429 Protein of unknown function (DUF3175); Region: DUF3175; pfam11373 398527004430 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 398527004431 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 398527004432 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 398527004433 Cupin; Region: Cupin_6; pfam12852 398527004434 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 398527004435 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 398527004436 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 398527004437 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 398527004438 active site 398527004439 catalytic tetrad [active] 398527004440 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 398527004441 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 398527004442 ATP binding site [chemical binding]; other site 398527004443 putative Mg++ binding site [ion binding]; other site 398527004444 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 398527004445 nucleotide binding region [chemical binding]; other site 398527004446 ATP-binding site [chemical binding]; other site 398527004447 DEAD/H associated; Region: DEAD_assoc; pfam08494 398527004448 RNase II stability modulator; Provisional; Region: PRK10060 398527004449 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 398527004450 putative active site [active] 398527004451 heme pocket [chemical binding]; other site 398527004452 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 398527004453 metal binding site [ion binding]; metal-binding site 398527004454 active site 398527004455 I-site; other site 398527004456 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 398527004457 enoyl-CoA hydratase; Validated; Region: PRK08788 398527004458 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 398527004459 substrate binding site [chemical binding]; other site 398527004460 oxyanion hole (OAH) forming residues; other site 398527004461 trimer interface [polypeptide binding]; other site 398527004462 putative dehydrogenase; Provisional; Region: PRK10098 398527004463 hypothetical protein; Provisional; Region: PRK07907 398527004464 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682 398527004465 metal binding site [ion binding]; metal-binding site 398527004466 putative dimer interface [polypeptide binding]; other site 398527004467 Superinfection immunity protein; Region: Imm_superinfect; pfam14373 398527004468 Uncharacterized small protein (DUF2158); Region: DUF2158; pfam09926 398527004469 Heat-labile enterotoxin alpha chain; Region: Enterotoxin_a; pfam01375 398527004470 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527004471 putative substrate translocation pore; other site 398527004472 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527004473 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 398527004474 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 398527004475 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 398527004476 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 398527004477 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 398527004478 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 398527004479 hypothetical protein; Provisional; Region: PRK07483 398527004480 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 398527004481 inhibitor-cofactor binding pocket; inhibition site 398527004482 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527004483 catalytic residue [active] 398527004484 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 398527004485 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 398527004486 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 398527004487 putative active site [active] 398527004488 Transcriptional regulators [Transcription]; Region: FadR; COG2186 398527004489 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527004490 DNA-binding site [nucleotide binding]; DNA binding site 398527004491 FCD domain; Region: FCD; pfam07729 398527004492 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 398527004493 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 398527004494 Walker A/P-loop; other site 398527004495 ATP binding site [chemical binding]; other site 398527004496 Q-loop/lid; other site 398527004497 ABC transporter signature motif; other site 398527004498 Walker B; other site 398527004499 D-loop; other site 398527004500 H-loop/switch region; other site 398527004501 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 398527004502 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 398527004503 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 398527004504 TM-ABC transporter signature motif; other site 398527004505 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 398527004506 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 398527004507 putative ligand binding site [chemical binding]; other site 398527004508 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 398527004509 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 398527004510 active site 398527004511 catalytic tetrad [active] 398527004512 Amidohydrolase; Region: Amidohydro_2; pfam04909 398527004513 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 398527004514 active site 398527004515 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 398527004516 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 398527004517 putative NAD(P) binding site [chemical binding]; other site 398527004518 catalytic Zn binding site [ion binding]; other site 398527004519 structural Zn binding site [ion binding]; other site 398527004520 altronate oxidoreductase; Provisional; Region: PRK03643 398527004521 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 398527004522 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 398527004523 galactarate dehydratase; Region: galactar-dH20; TIGR03248 398527004524 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 398527004525 Domain of unknown function (DUF718); Region: DUF718; pfam05336 398527004526 Protein required for attachment to host cells; Region: Host_attach; pfam10116 398527004527 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 398527004528 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 398527004529 FMN binding site [chemical binding]; other site 398527004530 active site 398527004531 substrate binding site [chemical binding]; other site 398527004532 catalytic residue [active] 398527004533 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 398527004534 NADH(P)-binding; Region: NAD_binding_10; pfam13460 398527004535 NAD(P) binding site [chemical binding]; other site 398527004536 putative active site [active] 398527004537 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 398527004538 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 398527004539 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527004540 PRC-barrel domain; Region: PRC; pfam05239 398527004541 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 398527004542 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 398527004543 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 398527004544 putative dimer interface [polypeptide binding]; other site 398527004545 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 398527004546 Clp amino terminal domain; Region: Clp_N; pfam02861 398527004547 Clp amino terminal domain; Region: Clp_N; pfam02861 398527004548 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527004549 Walker A motif; other site 398527004550 ATP binding site [chemical binding]; other site 398527004551 Walker B motif; other site 398527004552 arginine finger; other site 398527004553 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527004554 Walker A motif; other site 398527004555 ATP binding site [chemical binding]; other site 398527004556 Walker B motif; other site 398527004557 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 398527004558 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 398527004559 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 398527004560 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 398527004561 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 398527004562 Phosphate-starvation-inducible E; Region: PsiE; pfam06146 398527004563 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 398527004564 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527004565 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527004566 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 398527004567 putative effector binding pocket; other site 398527004568 dimerization interface [polypeptide binding]; other site 398527004569 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 398527004570 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 398527004571 catalytic residues [active] 398527004572 hypothetical protein; Provisional; Region: PRK07236 398527004573 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 398527004574 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527004575 Major Facilitator Superfamily; Region: MFS_1; pfam07690 398527004576 putative substrate translocation pore; other site 398527004577 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 398527004578 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 398527004579 Cytochrome c; Region: Cytochrom_C; pfam00034 398527004580 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 398527004581 Cytochrome c; Region: Cytochrom_C; pfam00034 398527004582 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 398527004583 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 398527004584 catalytic loop [active] 398527004585 iron binding site [ion binding]; other site 398527004586 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 398527004587 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 398527004588 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 398527004589 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 398527004590 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 398527004591 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527004592 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527004593 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 398527004594 substrate binding pocket [chemical binding]; other site 398527004595 dimerization interface [polypeptide binding]; other site 398527004596 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 398527004597 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 398527004598 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 398527004599 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 398527004600 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 398527004601 active site 398527004602 metal binding site [ion binding]; metal-binding site 398527004603 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 398527004604 active site 398527004605 catalytic site [active] 398527004606 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 398527004607 CoA-transferase family III; Region: CoA_transf_3; pfam02515 398527004608 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 398527004609 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 398527004610 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 398527004611 shikimate binding site; other site 398527004612 NAD(P) binding site [chemical binding]; other site 398527004613 Cache domain; Region: Cache_1; pfam02743 398527004614 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 398527004615 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 398527004616 metal binding site [ion binding]; metal-binding site 398527004617 active site 398527004618 I-site; other site 398527004619 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 398527004620 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 398527004621 putative NAD(P) binding site [chemical binding]; other site 398527004622 putative substrate binding site [chemical binding]; other site 398527004623 catalytic Zn binding site [ion binding]; other site 398527004624 structural Zn binding site [ion binding]; other site 398527004625 dimer interface [polypeptide binding]; other site 398527004626 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 398527004627 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 398527004628 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 398527004629 Coenzyme A binding pocket [chemical binding]; other site 398527004630 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 398527004631 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 398527004632 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 398527004633 NAD binding site [chemical binding]; other site 398527004634 catalytic residues [active] 398527004635 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 398527004636 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 398527004637 metal binding site [ion binding]; metal-binding site 398527004638 putative dimer interface [polypeptide binding]; other site 398527004639 citrate-proton symporter; Provisional; Region: PRK15075 398527004640 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527004641 putative substrate translocation pore; other site 398527004642 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 398527004643 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 398527004644 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 398527004645 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 398527004646 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527004647 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527004648 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 398527004649 putative dimerization interface [polypeptide binding]; other site 398527004650 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 398527004651 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 398527004652 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 398527004653 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 398527004654 dimer interface [polypeptide binding]; other site 398527004655 active site 398527004656 citrylCoA binding site [chemical binding]; other site 398527004657 NADH binding [chemical binding]; other site 398527004658 cationic pore residues; other site 398527004659 oxalacetate/citrate binding site [chemical binding]; other site 398527004660 coenzyme A binding site [chemical binding]; other site 398527004661 catalytic triad [active] 398527004662 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 398527004663 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 398527004664 catalytic site [active] 398527004665 rod shape-determining protein MreB; Provisional; Region: PRK13930 398527004666 MreB and similar proteins; Region: MreB_like; cd10225 398527004667 nucleotide binding site [chemical binding]; other site 398527004668 Mg binding site [ion binding]; other site 398527004669 putative protofilament interaction site [polypeptide binding]; other site 398527004670 RodZ interaction site [polypeptide binding]; other site 398527004671 putative hydrolase; Provisional; Region: PRK11460 398527004672 Predicted esterase [General function prediction only]; Region: COG0400 398527004673 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 398527004674 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527004675 putative substrate translocation pore; other site 398527004676 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527004677 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 398527004678 Helix-turn-helix domain; Region: HTH_18; pfam12833 398527004679 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527004680 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 398527004681 glutaminase; Provisional; Region: PRK00971 398527004682 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 398527004683 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 398527004684 putative NAD(P) binding site [chemical binding]; other site 398527004685 dimer interface [polypeptide binding]; other site 398527004686 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 398527004687 active site 398527004688 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 398527004689 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 398527004690 trimer interface [polypeptide binding]; other site 398527004691 eyelet of channel; other site 398527004692 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 398527004693 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 398527004694 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 398527004695 ligand binding site [chemical binding]; other site 398527004696 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 398527004697 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 398527004698 LemA family; Region: LemA; cl00742 398527004699 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 398527004700 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 398527004701 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 398527004702 BON domain; Region: BON; pfam04972 398527004703 BON domain; Region: BON; pfam04972 398527004704 Phasin protein; Region: Phasin_2; cl11491 398527004705 FOG: CBS domain [General function prediction only]; Region: COG0517 398527004706 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 398527004707 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 398527004708 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 398527004709 PAS domain; Region: PAS_9; pfam13426 398527004710 putative active site [active] 398527004711 heme pocket [chemical binding]; other site 398527004712 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 398527004713 Histidine kinase; Region: HisKA_3; pfam07730 398527004714 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527004715 ATP binding site [chemical binding]; other site 398527004716 Mg2+ binding site [ion binding]; other site 398527004717 G-X-G motif; other site 398527004718 Lecithin retinol acyltransferase; Region: LRAT; pfam04970 398527004719 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 398527004720 Ligand Binding Site [chemical binding]; other site 398527004721 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 398527004722 core domain interface [polypeptide binding]; other site 398527004723 delta subunit interface [polypeptide binding]; other site 398527004724 epsilon subunit interface [polypeptide binding]; other site 398527004725 F0F1 ATP synthase subunit alpha; Provisional; Region: PRK13343 398527004726 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 398527004727 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 398527004728 Walker A motif; other site 398527004729 ATP binding site [chemical binding]; other site 398527004730 Walker B motif; other site 398527004731 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 398527004732 alternate F1F0 ATPase, F0 subunit B; Region: alt_F1F0_F0_B; TIGR03321 398527004733 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 398527004734 F0F1 ATP synthase subunit C; Provisional; Region: PRK13468 398527004735 F0F1 ATP synthase subunit A; Provisional; Region: PRK13421 398527004736 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 398527004737 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 398527004738 F0F1 ATP synthase subunit epsilon; Provisional; Region: PRK13447 398527004739 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 398527004740 gamma subunit interface [polypeptide binding]; other site 398527004741 epsilon subunit interface [polypeptide binding]; other site 398527004742 LBP interface [polypeptide binding]; other site 398527004743 F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597 398527004744 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 398527004745 alpha subunit interaction interface [polypeptide binding]; other site 398527004746 Walker A motif; other site 398527004747 ATP binding site [chemical binding]; other site 398527004748 Walker B motif; other site 398527004749 inhibitor binding site; inhibition site 398527004750 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 398527004751 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 398527004752 BON domain; Region: BON; pfam04972 398527004753 BON domain; Region: BON; pfam04972 398527004754 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 398527004755 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 398527004756 catalytic Zn binding site [ion binding]; other site 398527004757 structural Zn binding site [ion binding]; other site 398527004758 NAD(P) binding site [chemical binding]; other site 398527004759 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 398527004760 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 398527004761 NAD(P) binding site [chemical binding]; other site 398527004762 homotetramer interface [polypeptide binding]; other site 398527004763 homodimer interface [polypeptide binding]; other site 398527004764 active site 398527004765 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 398527004766 Ligand Binding Site [chemical binding]; other site 398527004767 Ion channel; Region: Ion_trans_2; pfam07885 398527004768 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 398527004769 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 398527004770 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 398527004771 arginine deiminase; Provisional; Region: PRK01388 398527004772 ornithine carbamoyltransferase; Validated; Region: PRK02102 398527004773 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 398527004774 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 398527004775 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 398527004776 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 398527004777 putative substrate binding site [chemical binding]; other site 398527004778 nucleotide binding site [chemical binding]; other site 398527004779 nucleotide binding site [chemical binding]; other site 398527004780 homodimer interface [polypeptide binding]; other site 398527004781 bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190 398527004782 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 398527004783 dimer interaction site [polypeptide binding]; other site 398527004784 substrate-binding tunnel; other site 398527004785 active site 398527004786 catalytic site [active] 398527004787 substrate binding site [chemical binding]; other site 398527004788 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 398527004789 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 398527004790 Ligand Binding Site [chemical binding]; other site 398527004791 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 398527004792 Ligand Binding Site [chemical binding]; other site 398527004793 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 398527004794 Ligand Binding Site [chemical binding]; other site 398527004795 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 398527004796 Ligand Binding Site [chemical binding]; other site 398527004797 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 398527004798 Ligand Binding Site [chemical binding]; other site 398527004799 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 398527004800 Ligand Binding Site [chemical binding]; other site 398527004801 sensory histidine kinase UhpB; Provisional; Region: PRK11644 398527004802 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 398527004803 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527004804 active site 398527004805 phosphorylation site [posttranslational modification] 398527004806 intermolecular recognition site; other site 398527004807 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 398527004808 DNA binding residues [nucleotide binding] 398527004809 dimerization interface [polypeptide binding]; other site 398527004810 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 398527004811 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 398527004812 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 398527004813 NADPH bind site [chemical binding]; other site 398527004814 putative FMN binding site [chemical binding]; other site 398527004815 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 398527004816 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 398527004817 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 398527004818 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 398527004819 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 398527004820 Walker A/P-loop; other site 398527004821 ATP binding site [chemical binding]; other site 398527004822 Q-loop/lid; other site 398527004823 ABC transporter signature motif; other site 398527004824 Walker B; other site 398527004825 D-loop; other site 398527004826 H-loop/switch region; other site 398527004827 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 398527004828 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 398527004829 FtsX-like permease family; Region: FtsX; pfam02687 398527004830 Protein of unknown function (DUF2964); Region: DUF2964; pfam11177 398527004831 acetyl-CoA synthetase; Provisional; Region: PRK00174 398527004832 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 398527004833 active site 398527004834 CoA binding site [chemical binding]; other site 398527004835 acyl-activating enzyme (AAE) consensus motif; other site 398527004836 AMP binding site [chemical binding]; other site 398527004837 acetate binding site [chemical binding]; other site 398527004838 Predicted membrane protein [Function unknown]; Region: COG1584 398527004839 Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551 398527004840 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 398527004841 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 398527004842 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 398527004843 putative FMN binding site [chemical binding]; other site 398527004844 NADPH bind site [chemical binding]; other site 398527004845 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 398527004846 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 398527004847 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 398527004848 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 398527004849 Beta-Casp domain; Region: Beta-Casp; smart01027 398527004850 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 398527004851 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 398527004852 FMN binding site [chemical binding]; other site 398527004853 dimer interface [polypeptide binding]; other site 398527004854 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 398527004855 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 398527004856 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 398527004857 Sulfate transporter family; Region: Sulfate_transp; pfam00916 398527004858 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 398527004859 Predicted transporter component [General function prediction only]; Region: COG2391 398527004860 Predicted membrane protein (DUF2335); Region: DUF2335; cl02210 398527004861 Sulphur transport; Region: Sulf_transp; pfam04143 398527004862 Predicted transporter component [General function prediction only]; Region: COG2391 398527004863 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 398527004864 Ligand Binding Site [chemical binding]; other site 398527004865 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 398527004866 Ligand Binding Site [chemical binding]; other site 398527004867 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 398527004868 putative active site [active] 398527004869 putative metal binding site [ion binding]; other site 398527004870 Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200 398527004871 Beta-lactamase; Region: Beta-lactamase; pfam00144 398527004872 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 398527004873 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 398527004874 Hemerythrin-like domain; Region: Hr-like; cd12108 398527004875 Fe binding site [ion binding]; other site 398527004876 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 398527004877 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 398527004878 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 398527004879 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 398527004880 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 398527004881 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 398527004882 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 398527004883 CreA protein; Region: CreA; pfam05981 398527004884 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 398527004885 dimerization interface [polypeptide binding]; other site 398527004886 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 398527004887 PAS domain; Region: PAS_9; pfam13426 398527004888 putative active site [active] 398527004889 heme pocket [chemical binding]; other site 398527004890 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 398527004891 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 398527004892 metal binding site [ion binding]; metal-binding site 398527004893 active site 398527004894 I-site; other site 398527004895 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 398527004896 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 398527004897 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 398527004898 NAD binding site [chemical binding]; other site 398527004899 ligand binding site [chemical binding]; other site 398527004900 catalytic site [active] 398527004901 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 398527004902 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527004903 putative substrate translocation pore; other site 398527004904 aldolase II superfamily protein; Provisional; Region: PRK07044 398527004905 intersubunit interface [polypeptide binding]; other site 398527004906 active site 398527004907 Zn2+ binding site [ion binding]; other site 398527004908 metabolite-proton symporter; Region: 2A0106; TIGR00883 398527004909 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527004910 putative substrate translocation pore; other site 398527004911 tricarballylate utilization protein B; Provisional; Region: PRK15033 398527004912 tricarballylate dehydrogenase; Validated; Region: PRK08274 398527004913 Predicted oxidoreductase [General function prediction only]; Region: COG3573 398527004914 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527004915 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527004916 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 398527004917 putative dimerization interface [polypeptide binding]; other site 398527004918 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527004919 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527004920 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 398527004921 dimerization interface [polypeptide binding]; other site 398527004922 Predicted transcriptional regulators [Transcription]; Region: COG1695 398527004923 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 398527004924 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 398527004925 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 398527004926 FAD binding pocket [chemical binding]; other site 398527004927 FAD binding motif [chemical binding]; other site 398527004928 phosphate binding motif [ion binding]; other site 398527004929 NAD binding pocket [chemical binding]; other site 398527004930 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 398527004931 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 398527004932 DAK2 domain; Region: Dak2; cl03685 398527004933 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 398527004934 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 398527004935 Walker A/P-loop; other site 398527004936 ATP binding site [chemical binding]; other site 398527004937 Q-loop/lid; other site 398527004938 ABC transporter signature motif; other site 398527004939 Walker B; other site 398527004940 D-loop; other site 398527004941 H-loop/switch region; other site 398527004942 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 398527004943 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 398527004944 Walker A/P-loop; other site 398527004945 ATP binding site [chemical binding]; other site 398527004946 Q-loop/lid; other site 398527004947 ABC transporter signature motif; other site 398527004948 Walker B; other site 398527004949 D-loop; other site 398527004950 H-loop/switch region; other site 398527004951 TOBE domain; Region: TOBE_2; pfam08402 398527004952 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 398527004953 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527004954 dimer interface [polypeptide binding]; other site 398527004955 conserved gate region; other site 398527004956 putative PBP binding loops; other site 398527004957 ABC-ATPase subunit interface; other site 398527004958 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 398527004959 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527004960 dimer interface [polypeptide binding]; other site 398527004961 conserved gate region; other site 398527004962 putative PBP binding loops; other site 398527004963 ABC-ATPase subunit interface; other site 398527004964 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 398527004965 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 398527004966 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 398527004967 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 398527004968 DNA binding site [nucleotide binding] 398527004969 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 398527004970 putative ligand binding site [chemical binding]; other site 398527004971 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 398527004972 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 398527004973 Domain of unknown function DUF20; Region: UPF0118; pfam01594 398527004974 CsbD-like; Region: CsbD; pfam05532 398527004975 CsbD-like; Region: CsbD; pfam05532 398527004976 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 398527004977 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 398527004978 substrate binding site [chemical binding]; other site 398527004979 oxyanion hole (OAH) forming residues; other site 398527004980 trimer interface [polypeptide binding]; other site 398527004981 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 398527004982 enoyl-CoA hydratase; Provisional; Region: PRK09076 398527004983 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 398527004984 substrate binding site [chemical binding]; other site 398527004985 oxyanion hole (OAH) forming residues; other site 398527004986 trimer interface [polypeptide binding]; other site 398527004987 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 398527004988 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 398527004989 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 398527004990 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 398527004991 tetrameric interface [polypeptide binding]; other site 398527004992 NAD binding site [chemical binding]; other site 398527004993 catalytic residues [active] 398527004994 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 398527004995 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_1; cd05974 398527004996 active site 398527004997 acyl-activating enzyme (AAE) consensus motif; other site 398527004998 putative CoA binding site [chemical binding]; other site 398527004999 AMP binding site [chemical binding]; other site 398527005000 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 398527005001 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 398527005002 active site 398527005003 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 398527005004 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 398527005005 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527005006 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 398527005007 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 398527005008 dimer interface [polypeptide binding]; other site 398527005009 active site residues [active] 398527005010 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 398527005011 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 398527005012 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 398527005013 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 398527005014 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 398527005015 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 398527005016 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 398527005017 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 398527005018 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 398527005019 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 398527005020 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 398527005021 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527005022 Walker A motif; other site 398527005023 ATP binding site [chemical binding]; other site 398527005024 Walker B motif; other site 398527005025 arginine finger; other site 398527005026 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 398527005027 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 398527005028 catalytic loop [active] 398527005029 iron binding site [ion binding]; other site 398527005030 Protein of unknown function (DUF1653); Region: DUF1653; cl01949 398527005031 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 398527005032 YheO-like PAS domain; Region: PAS_6; pfam08348 398527005033 HTH domain; Region: HTH_22; pfam13309 398527005034 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 398527005035 rRNA binding site [nucleotide binding]; other site 398527005036 predicted 30S ribosome binding site; other site 398527005037 Transcriptional regulators [Transcription]; Region: GntR; COG1802 398527005038 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527005039 DNA-binding site [nucleotide binding]; DNA binding site 398527005040 FCD domain; Region: FCD; pfam07729 398527005041 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 398527005042 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD_like; cd08296 398527005043 putative NAD(P) binding site [chemical binding]; other site 398527005044 putative substrate binding site [chemical binding]; other site 398527005045 catalytic Zn binding site [ion binding]; other site 398527005046 structural Zn binding site [ion binding]; other site 398527005047 translation initiation factor Sui1; Validated; Region: PRK06824 398527005048 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 398527005049 putative rRNA binding site [nucleotide binding]; other site 398527005050 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 398527005051 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 398527005052 metal binding site [ion binding]; metal-binding site 398527005053 active site 398527005054 I-site; other site 398527005055 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 398527005056 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 398527005057 tetrameric interface [polypeptide binding]; other site 398527005058 NAD binding site [chemical binding]; other site 398527005059 catalytic residues [active] 398527005060 putative cyanate transporter; Provisional; Region: cynX; PRK09705 398527005061 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 398527005062 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527005063 active site 398527005064 phosphorylation site [posttranslational modification] 398527005065 intermolecular recognition site; other site 398527005066 dimerization interface [polypeptide binding]; other site 398527005067 ANTAR domain; Region: ANTAR; pfam03861 398527005068 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 398527005069 NMT1-like family; Region: NMT1_2; pfam13379 398527005070 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 398527005071 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 398527005072 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 398527005073 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527005074 dimer interface [polypeptide binding]; other site 398527005075 conserved gate region; other site 398527005076 ABC-ATPase subunit interface; other site 398527005077 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527005078 dimer interface [polypeptide binding]; other site 398527005079 conserved gate region; other site 398527005080 putative PBP binding loops; other site 398527005081 ABC-ATPase subunit interface; other site 398527005082 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 398527005083 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 398527005084 Walker A/P-loop; other site 398527005085 ATP binding site [chemical binding]; other site 398527005086 Q-loop/lid; other site 398527005087 ABC transporter signature motif; other site 398527005088 Walker B; other site 398527005089 D-loop; other site 398527005090 H-loop/switch region; other site 398527005091 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 398527005092 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 398527005093 trimer interface [polypeptide binding]; other site 398527005094 eyelet of channel; other site 398527005095 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 398527005096 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 398527005097 ligand binding site [chemical binding]; other site 398527005098 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 398527005099 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 398527005100 TM-ABC transporter signature motif; other site 398527005101 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 398527005102 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 398527005103 TM-ABC transporter signature motif; other site 398527005104 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 398527005105 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 398527005106 Walker A/P-loop; other site 398527005107 ATP binding site [chemical binding]; other site 398527005108 Q-loop/lid; other site 398527005109 ABC transporter signature motif; other site 398527005110 Walker B; other site 398527005111 D-loop; other site 398527005112 H-loop/switch region; other site 398527005113 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 398527005114 Amidohydrolase; Region: Amidohydro_2; pfam04909 398527005115 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 398527005116 Domain of unknown function (DUF718); Region: DUF718; pfam05336 398527005117 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 398527005118 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527005119 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 398527005120 putative dimerization interface [polypeptide binding]; other site 398527005121 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 398527005122 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 398527005123 NAD(P) binding site [chemical binding]; other site 398527005124 active site 398527005125 L-rhamnonate dehydratase; Provisional; Region: PRK15440 398527005126 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 398527005127 putative active site pocket [active] 398527005128 putative metal binding site [ion binding]; other site 398527005129 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527005130 Major Facilitator Superfamily; Region: MFS_1; pfam07690 398527005131 putative substrate translocation pore; other site 398527005132 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 398527005133 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 398527005134 NAD(P) binding site [chemical binding]; other site 398527005135 active site 398527005136 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 398527005137 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 398527005138 NAD(P) binding site [chemical binding]; other site 398527005139 active site 398527005140 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 398527005141 Proline racemase; Region: Pro_racemase; pfam05544 398527005142 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 398527005143 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 398527005144 dimerization interface [polypeptide binding]; other site 398527005145 ligand binding site [chemical binding]; other site 398527005146 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 398527005147 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 398527005148 putative acyl-acceptor binding pocket; other site 398527005149 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 398527005150 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 398527005151 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527005152 putative substrate translocation pore; other site 398527005153 Bacteriophage holin; Region: Phage_holin_1; cl02344 398527005154 H-NS histone family; Region: Histone_HNS; pfam00816 398527005155 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 398527005156 Low molecular weight phosphatase family; Region: LMWPc; cl00105 398527005157 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 398527005158 active site 398527005159 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 398527005160 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 398527005161 putative active site pocket [active] 398527005162 dimerization interface [polypeptide binding]; other site 398527005163 putative catalytic residue [active] 398527005164 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 398527005165 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 398527005166 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 398527005167 HSP70 interaction site [polypeptide binding]; other site 398527005168 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 398527005169 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 398527005170 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 398527005171 dinuclear metal binding motif [ion binding]; other site 398527005172 indole acetimide hydrolase; Validated; Region: PRK07488 398527005173 Amidase; Region: Amidase; cl11426 398527005174 CDP-diacylglycerol pyrophosphatase; Region: CDH; pfam02611 398527005175 Fatty acid desaturase protein family subgroup, a delta-12 acyl-lipid desaturase-like, DesA-like, yet uncharacterized subgroup of membrane fatty acid desaturase proteins found in alpha-, beta-, and gamma-proteobacteria. Sequences of this domain family...; Region: DesA_FADS-like; cd03509 398527005176 Fatty acid desaturase; Region: FA_desaturase; pfam00487 398527005177 putative di-iron ligands [ion binding]; other site 398527005178 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527005179 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527005180 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 398527005181 putative effector binding pocket; other site 398527005182 putative dimerization interface [polypeptide binding]; other site 398527005183 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 398527005184 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 398527005185 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 398527005186 Phosphoglycerate mutase family; Region: PGAM; smart00855 398527005187 catalytic core [active] 398527005188 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 398527005189 Found in ATP-dependent protease La (LON); Region: LON; smart00464 398527005190 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527005191 Walker A motif; other site 398527005192 ATP binding site [chemical binding]; other site 398527005193 Walker B motif; other site 398527005194 arginine finger; other site 398527005195 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 398527005196 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 398527005197 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 398527005198 putative dimer interface [polypeptide binding]; other site 398527005199 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 398527005200 TOBE domain; Region: TOBE; cl01440 398527005201 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 398527005202 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 398527005203 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 398527005204 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 398527005205 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 398527005206 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 398527005207 dinuclear metal binding motif [ion binding]; other site 398527005208 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527005209 active site 398527005210 phosphorylation site [posttranslational modification] 398527005211 intermolecular recognition site; other site 398527005212 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 398527005213 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 398527005214 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 398527005215 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 398527005216 putative dimer interface [polypeptide binding]; other site 398527005217 Tar ligand binding domain homologue; Region: TarH; pfam02203 398527005218 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 398527005219 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 398527005220 dimerization interface [polypeptide binding]; other site 398527005221 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 398527005222 dimer interface [polypeptide binding]; other site 398527005223 putative CheW interface [polypeptide binding]; other site 398527005224 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 398527005225 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 398527005226 dimer interface [polypeptide binding]; other site 398527005227 NADP binding site [chemical binding]; other site 398527005228 catalytic residues [active] 398527005229 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 398527005230 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527005231 Major Facilitator Superfamily; Region: MFS_1; pfam07690 398527005232 putative substrate translocation pore; other site 398527005233 hypothetical protein; Validated; Region: PRK08245 398527005234 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 398527005235 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 398527005236 trimer interface [polypeptide binding]; other site 398527005237 eyelet of channel; other site 398527005238 Predicted dehydrogenase [General function prediction only]; Region: COG0579 398527005239 hydroxyglutarate oxidase; Provisional; Region: PRK11728 398527005240 Transcriptional regulators [Transcription]; Region: FadR; COG2186 398527005241 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527005242 DNA-binding site [nucleotide binding]; DNA binding site 398527005243 FCD domain; Region: FCD; pfam07729 398527005244 metabolite-proton symporter; Region: 2A0106; TIGR00883 398527005245 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527005246 putative substrate translocation pore; other site 398527005247 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 398527005248 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 398527005249 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 398527005250 active site 398527005251 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 398527005252 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527005253 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 398527005254 putative dimerization interface [polypeptide binding]; other site 398527005255 KduI/IolB family; Region: KduI; pfam04962 398527005256 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 398527005257 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 398527005258 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 398527005259 mannonate dehydratase; Provisional; Region: PRK03906 398527005260 mannonate dehydratase; Region: uxuA; TIGR00695 398527005261 PAS fold; Region: PAS_4; pfam08448 398527005262 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 398527005263 putative active site [active] 398527005264 heme pocket [chemical binding]; other site 398527005265 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 398527005266 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 398527005267 metal binding site [ion binding]; metal-binding site 398527005268 active site 398527005269 I-site; other site 398527005270 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 398527005271 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 398527005272 Amidase; Region: Amidase; cl11426 398527005273 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 398527005274 classical (c) SDRs; Region: SDR_c; cd05233 398527005275 NAD(P) binding site [chemical binding]; other site 398527005276 active site 398527005277 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 398527005278 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 398527005279 active site 398527005280 dimerization interface [polypeptide binding]; other site 398527005281 ANTAR domain; Region: ANTAR; pfam03861 398527005282 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 398527005283 Periplasmic binding domain of amidase (AmiC) that belongs to the type I periplasmic binding fold protein family; Region: PBP1_AmiC; cd06357 398527005284 ligand binding site [chemical binding]; other site 398527005285 regulator interaction site; other site 398527005286 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 398527005287 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 398527005288 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 398527005289 Walker A/P-loop; other site 398527005290 ATP binding site [chemical binding]; other site 398527005291 Q-loop/lid; other site 398527005292 ABC transporter signature motif; other site 398527005293 Walker B; other site 398527005294 D-loop; other site 398527005295 H-loop/switch region; other site 398527005296 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 398527005297 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 398527005298 Walker A/P-loop; other site 398527005299 ATP binding site [chemical binding]; other site 398527005300 Q-loop/lid; other site 398527005301 ABC transporter signature motif; other site 398527005302 Walker B; other site 398527005303 D-loop; other site 398527005304 H-loop/switch region; other site 398527005305 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 398527005306 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 398527005307 TM-ABC transporter signature motif; other site 398527005308 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 398527005309 TM-ABC transporter signature motif; other site 398527005310 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 398527005311 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_Amide_Urea_BP_like; cd06356 398527005312 putative ligand binding site [chemical binding]; other site 398527005313 Predicted transcriptional regulators [Transcription]; Region: COG1733 398527005314 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 398527005315 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 398527005316 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 398527005317 putative NAD(P) binding site [chemical binding]; other site 398527005318 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 398527005319 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 398527005320 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 398527005321 putative DNA binding site [nucleotide binding]; other site 398527005322 putative Zn2+ binding site [ion binding]; other site 398527005323 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 398527005324 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 398527005325 putative metal binding site [ion binding]; other site 398527005326 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 398527005327 Low molecular weight phosphatase family; Region: LMWPc; cd00115 398527005328 active site 398527005329 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 398527005330 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 398527005331 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 398527005332 Beta-lactamase; Region: Beta-lactamase; pfam00144 398527005333 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 398527005334 CoA binding domain; Region: CoA_binding_2; pfam13380 398527005335 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 398527005336 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 398527005337 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 398527005338 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 398527005339 substrate binding site [chemical binding]; other site 398527005340 oxyanion hole (OAH) forming residues; other site 398527005341 trimer interface [polypeptide binding]; other site 398527005342 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527005343 D-galactonate transporter; Region: 2A0114; TIGR00893 398527005344 putative substrate translocation pore; other site 398527005345 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 398527005346 Transcriptional regulator [Transcription]; Region: IclR; COG1414 398527005347 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 398527005348 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527005349 ATP binding site [chemical binding]; other site 398527005350 Mg2+ binding site [ion binding]; other site 398527005351 G-X-G motif; other site 398527005352 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 398527005353 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 398527005354 dimer interface [polypeptide binding]; other site 398527005355 phosphorylation site [posttranslational modification] 398527005356 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527005357 ATP binding site [chemical binding]; other site 398527005358 Mg2+ binding site [ion binding]; other site 398527005359 G-X-G motif; other site 398527005360 Response regulator receiver domain; Region: Response_reg; pfam00072 398527005361 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527005362 active site 398527005363 phosphorylation site [posttranslational modification] 398527005364 intermolecular recognition site; other site 398527005365 dimerization interface [polypeptide binding]; other site 398527005366 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 398527005367 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 398527005368 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 398527005369 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527005370 ATP binding site [chemical binding]; other site 398527005371 Mg2+ binding site [ion binding]; other site 398527005372 G-X-G motif; other site 398527005373 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 398527005374 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 398527005375 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 398527005376 Transcriptional regulator [Transcription]; Region: IclR; COG1414 398527005377 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 398527005378 putative DNA binding site [nucleotide binding]; other site 398527005379 putative Zn2+ binding site [ion binding]; other site 398527005380 Bacterial transcriptional regulator; Region: IclR; pfam01614 398527005381 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527005382 metabolite-proton symporter; Region: 2A0106; TIGR00883 398527005383 putative substrate translocation pore; other site 398527005384 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 398527005385 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527005386 DNA-binding site [nucleotide binding]; DNA binding site 398527005387 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 398527005388 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527005389 homodimer interface [polypeptide binding]; other site 398527005390 catalytic residue [active] 398527005391 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 398527005392 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 398527005393 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527005394 DNA-binding site [nucleotide binding]; DNA binding site 398527005395 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 398527005396 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527005397 homodimer interface [polypeptide binding]; other site 398527005398 catalytic residue [active] 398527005399 Transcriptional regulator [Transcription]; Region: IclR; COG1414 398527005400 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 398527005401 Bacterial transcriptional regulator; Region: IclR; pfam01614 398527005402 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527005403 metabolite-proton symporter; Region: 2A0106; TIGR00883 398527005404 putative substrate translocation pore; other site 398527005405 Cupin domain; Region: Cupin_2; cl17218 398527005406 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 398527005407 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 398527005408 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 398527005409 shikimate binding site; other site 398527005410 NAD(P) binding site [chemical binding]; other site 398527005411 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 398527005412 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 398527005413 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 398527005414 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 398527005415 galactarate dehydratase; Region: galactar-dH20; TIGR03248 398527005416 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 398527005417 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 398527005418 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 398527005419 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 398527005420 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 398527005421 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527005422 metabolite-proton symporter; Region: 2A0106; TIGR00883 398527005423 putative substrate translocation pore; other site 398527005424 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527005425 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 398527005426 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 398527005427 trimer interface [polypeptide binding]; other site 398527005428 eyelet of channel; other site 398527005429 Fumarylacetoacetate (FAA) hydrolase family protein [General function prediction only]; Region: COG3970 398527005430 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 398527005431 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 398527005432 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 398527005433 NAD(P) binding site [chemical binding]; other site 398527005434 catalytic residues [active] 398527005435 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 398527005436 putative DNA binding site [nucleotide binding]; other site 398527005437 dimerization interface [polypeptide binding]; other site 398527005438 putative Zn2+ binding site [ion binding]; other site 398527005439 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 398527005440 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 398527005441 FMN binding site [chemical binding]; other site 398527005442 active site 398527005443 substrate binding site [chemical binding]; other site 398527005444 catalytic residue [active] 398527005445 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 398527005446 Coenzyme A binding pocket [chemical binding]; other site 398527005447 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 398527005448 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 398527005449 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 398527005450 putative hydrophobic ligand binding site [chemical binding]; other site 398527005451 CLM binding site; other site 398527005452 L1 loop; other site 398527005453 DNA binding site [nucleotide binding] 398527005454 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 398527005455 dimerization interface [polypeptide binding]; other site 398527005456 putative DNA binding site [nucleotide binding]; other site 398527005457 putative Zn2+ binding site [ion binding]; other site 398527005458 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 398527005459 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 398527005460 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 398527005461 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 398527005462 putative DNA binding site [nucleotide binding]; other site 398527005463 putative Zn2+ binding site [ion binding]; other site 398527005464 Isochorismatase family; Region: Isochorismatase; pfam00857 398527005465 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 398527005466 catalytic triad [active] 398527005467 conserved cis-peptide bond; other site 398527005468 H+ Antiporter protein; Region: 2A0121; TIGR00900 398527005469 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527005470 putative substrate translocation pore; other site 398527005471 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 398527005472 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 398527005473 tetrameric interface [polypeptide binding]; other site 398527005474 NAD binding site [chemical binding]; other site 398527005475 catalytic residues [active] 398527005476 transcriptional activator TtdR; Provisional; Region: PRK09801 398527005477 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527005478 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 398527005479 putative effector binding pocket; other site 398527005480 putative dimerization interface [polypeptide binding]; other site 398527005481 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527005482 metabolite-proton symporter; Region: 2A0106; TIGR00883 398527005483 putative substrate translocation pore; other site 398527005484 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 398527005485 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 398527005486 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 398527005487 Dehydroquinase class II; Region: DHquinase_II; pfam01220 398527005488 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 398527005489 trimer interface [polypeptide binding]; other site 398527005490 active site 398527005491 dimer interface [polypeptide binding]; other site 398527005492 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527005493 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527005494 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 398527005495 putative effector binding pocket; other site 398527005496 putative dimerization interface [polypeptide binding]; other site 398527005497 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 398527005498 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 398527005499 motif II; other site 398527005500 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 1; Region: PLPDE_III_DSD_D-TA_like_1; cd06812 398527005501 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 398527005502 active site 398527005503 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 398527005504 dimer interface [polypeptide binding]; other site 398527005505 substrate binding site [chemical binding]; other site 398527005506 catalytic residue [active] 398527005507 MarR family; Region: MarR_2; cl17246 398527005508 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 398527005509 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 398527005510 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 398527005511 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 398527005512 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 398527005513 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 398527005514 NAD binding site [chemical binding]; other site 398527005515 catalytic residues [active] 398527005516 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 398527005517 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 398527005518 putative active site [active] 398527005519 putative metal binding site [ion binding]; other site 398527005520 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 398527005521 putative substrate binding pocket [chemical binding]; other site 398527005522 trimer interface [polypeptide binding]; other site 398527005523 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 398527005524 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 398527005525 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 398527005526 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 398527005527 metal binding site [ion binding]; metal-binding site 398527005528 active site 398527005529 I-site; other site 398527005530 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 398527005531 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 398527005532 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 398527005533 metal binding site [ion binding]; metal-binding site 398527005534 active site 398527005535 I-site; other site 398527005536 Cellulose synthase subunit D; Region: Cellsynth_D; pfam03500 398527005537 cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371 398527005538 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 398527005539 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 398527005540 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 398527005541 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 398527005542 DXD motif; other site 398527005543 PilZ domain; Region: PilZ; pfam07238 398527005544 cellulose synthase regulator protein; Provisional; Region: PRK11114 398527005545 endo-1,4-D-glucanase; Provisional; Region: PRK11097 398527005546 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 398527005547 binding surface 398527005548 TPR motif; other site 398527005549 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 398527005550 binding surface 398527005551 TPR motif; other site 398527005552 Tetratricopeptide repeat; Region: TPR_16; pfam13432 398527005553 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 398527005554 TPR motif; other site 398527005555 binding surface 398527005556 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 398527005557 TPR motif; other site 398527005558 binding surface 398527005559 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 398527005560 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 398527005561 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 398527005562 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 398527005563 PAS fold; Region: PAS_3; pfam08447 398527005564 putative active site [active] 398527005565 heme pocket [chemical binding]; other site 398527005566 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 398527005567 dimer interface [polypeptide binding]; other site 398527005568 phosphorylation site [posttranslational modification] 398527005569 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527005570 ATP binding site [chemical binding]; other site 398527005571 G-X-G motif; other site 398527005572 Response regulator receiver domain; Region: Response_reg; pfam00072 398527005573 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527005574 active site 398527005575 phosphorylation site [posttranslational modification] 398527005576 intermolecular recognition site; other site 398527005577 dimerization interface [polypeptide binding]; other site 398527005578 Response regulator receiver domain; Region: Response_reg; pfam00072 398527005579 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527005580 active site 398527005581 phosphorylation site [posttranslational modification] 398527005582 intermolecular recognition site; other site 398527005583 dimerization interface [polypeptide binding]; other site 398527005584 Protein of unknown function DUF72; Region: DUF72; pfam01904 398527005585 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527005586 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527005587 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 398527005588 dimerization interface [polypeptide binding]; other site 398527005589 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 398527005590 dimerization interface [polypeptide binding]; other site 398527005591 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 398527005592 dimer interface [polypeptide binding]; other site 398527005593 phosphorylation site [posttranslational modification] 398527005594 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527005595 ATP binding site [chemical binding]; other site 398527005596 Mg2+ binding site [ion binding]; other site 398527005597 G-X-G motif; other site 398527005598 osmolarity response regulator; Provisional; Region: ompR; PRK09468 398527005599 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527005600 active site 398527005601 phosphorylation site [posttranslational modification] 398527005602 intermolecular recognition site; other site 398527005603 dimerization interface [polypeptide binding]; other site 398527005604 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 398527005605 DNA binding site [nucleotide binding] 398527005606 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 398527005607 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 398527005608 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 398527005609 HlyD family secretion protein; Region: HlyD_3; pfam13437 398527005610 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 398527005611 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 398527005612 pseudo EF-hand loop; other site 398527005613 peptide binding pocket; other site 398527005614 Ca2+ binding site [ion binding]; other site 398527005615 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 398527005616 transmembrane helices; other site 398527005617 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 398527005618 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 398527005619 PAS fold; Region: PAS_3; pfam08447 398527005620 putative active site [active] 398527005621 heme pocket [chemical binding]; other site 398527005622 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 398527005623 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 398527005624 metal binding site [ion binding]; metal-binding site 398527005625 active site 398527005626 I-site; other site 398527005627 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 398527005628 YceI-like domain; Region: YceI; smart00867 398527005629 Uncharacterized conserved protein [Function unknown]; Region: COG2353 398527005630 Predicted permeases [General function prediction only]; Region: COG0679 398527005631 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527005632 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527005633 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 398527005634 dimerization interface [polypeptide binding]; other site 398527005635 short chain dehydrogenase; Provisional; Region: PRK06500 398527005636 classical (c) SDRs; Region: SDR_c; cd05233 398527005637 NAD(P) binding site [chemical binding]; other site 398527005638 active site 398527005639 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 398527005640 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 398527005641 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 398527005642 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 398527005643 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 398527005644 catalytic residue [active] 398527005645 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 398527005646 active site 398527005647 DNA polymerase IV; Validated; Region: PRK02406 398527005648 DNA binding site [nucleotide binding] 398527005649 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 398527005650 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 398527005651 dimer interface [polypeptide binding]; other site 398527005652 phosphorylation site [posttranslational modification] 398527005653 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527005654 ATP binding site [chemical binding]; other site 398527005655 Mg2+ binding site [ion binding]; other site 398527005656 G-X-G motif; other site 398527005657 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 398527005658 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527005659 active site 398527005660 phosphorylation site [posttranslational modification] 398527005661 intermolecular recognition site; other site 398527005662 dimerization interface [polypeptide binding]; other site 398527005663 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 398527005664 DNA binding site [nucleotide binding] 398527005665 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 398527005666 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 398527005667 HlyD family secretion protein; Region: HlyD_3; pfam13437 398527005668 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 398527005669 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 398527005670 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 398527005671 putative metal binding site [ion binding]; other site 398527005672 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527005673 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527005674 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427 398527005675 putative dimerization interface [polypeptide binding]; other site 398527005676 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 398527005677 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375 398527005678 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 398527005679 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 398527005680 Sulfate transporter family; Region: Sulfate_transp; pfam00916 398527005681 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 398527005682 RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145 398527005683 ATP binding site [chemical binding]; other site 398527005684 Transcriptional regulators [Transcription]; Region: PurR; COG1609 398527005685 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 398527005686 DNA binding site [nucleotide binding] 398527005687 domain linker motif; other site 398527005688 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 398527005689 dimerization interface (closed form) [polypeptide binding]; other site 398527005690 ligand binding site [chemical binding]; other site 398527005691 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 398527005692 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 398527005693 Walker A/P-loop; other site 398527005694 ATP binding site [chemical binding]; other site 398527005695 Q-loop/lid; other site 398527005696 ABC transporter signature motif; other site 398527005697 Walker B; other site 398527005698 D-loop; other site 398527005699 H-loop/switch region; other site 398527005700 TOBE domain; Region: TOBE_2; pfam08402 398527005701 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 398527005702 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527005703 dimer interface [polypeptide binding]; other site 398527005704 conserved gate region; other site 398527005705 putative PBP binding loops; other site 398527005706 ABC-ATPase subunit interface; other site 398527005707 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527005708 dimer interface [polypeptide binding]; other site 398527005709 conserved gate region; other site 398527005710 putative PBP binding loops; other site 398527005711 ABC-ATPase subunit interface; other site 398527005712 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 398527005713 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 398527005714 beta-galactosidase; Region: BGL; TIGR03356 398527005715 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 398527005716 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 398527005717 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 398527005718 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 398527005719 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 398527005720 conserved cys residue [active] 398527005721 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 398527005722 active site residue [active] 398527005723 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 398527005724 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 398527005725 trimer interface [polypeptide binding]; other site 398527005726 eyelet of channel; other site 398527005727 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 398527005728 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 398527005729 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 398527005730 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 398527005731 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 398527005732 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 398527005733 metal binding site [ion binding]; metal-binding site 398527005734 active site 398527005735 I-site; other site 398527005736 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 398527005737 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 398527005738 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 398527005739 Peptidase family M23; Region: Peptidase_M23; pfam01551 398527005740 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 398527005741 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 398527005742 dimer interface [polypeptide binding]; other site 398527005743 active site 398527005744 catalytic residue [active] 398527005745 aspartate carbamoyltransferase; Provisional; Region: PRK11891 398527005746 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 398527005747 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 398527005748 Predicted esterase [General function prediction only]; Region: COG0627 398527005749 S-formylglutathione hydrolase; Region: PLN02442 398527005750 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 398527005751 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 398527005752 putative DNA binding site [nucleotide binding]; other site 398527005753 putative Zn2+ binding site [ion binding]; other site 398527005754 AsnC family; Region: AsnC_trans_reg; pfam01037 398527005755 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 398527005756 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 398527005757 motif II; other site 398527005758 Phosphotransferase enzyme family; Region: APH; pfam01636 398527005759 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 398527005760 active site 398527005761 ATP binding site [chemical binding]; other site 398527005762 substrate binding site [chemical binding]; other site 398527005763 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 398527005764 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 398527005765 inhibitor-cofactor binding pocket; inhibition site 398527005766 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527005767 catalytic residue [active] 398527005768 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 398527005769 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 398527005770 hydroxyglutarate oxidase; Provisional; Region: PRK11728 398527005771 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 398527005772 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 398527005773 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 398527005774 homotrimer interaction site [polypeptide binding]; other site 398527005775 putative active site [active] 398527005776 transcriptional regulator; Provisional; Region: PRK10632 398527005777 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527005778 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 398527005779 dimerization interface [polypeptide binding]; other site 398527005780 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 398527005781 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 398527005782 active site 398527005783 catalytic tetrad [active] 398527005784 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527005785 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527005786 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 398527005787 dimerization interface [polypeptide binding]; other site 398527005788 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 398527005789 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527005790 active site 398527005791 phosphorylation site [posttranslational modification] 398527005792 intermolecular recognition site; other site 398527005793 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 398527005794 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 398527005795 dimer interface [polypeptide binding]; other site 398527005796 phosphorylation site [posttranslational modification] 398527005797 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527005798 ATP binding site [chemical binding]; other site 398527005799 Mg2+ binding site [ion binding]; other site 398527005800 G-X-G motif; other site 398527005801 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 398527005802 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 398527005803 Coenzyme A binding pocket [chemical binding]; other site 398527005804 lipoyl synthase; Provisional; Region: PRK12928 398527005805 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 398527005806 FeS/SAM binding site; other site 398527005807 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 398527005808 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 398527005809 E3 interaction surface; other site 398527005810 lipoyl attachment site [posttranslational modification]; other site 398527005811 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 398527005812 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 398527005813 alpha subunit interface [polypeptide binding]; other site 398527005814 TPP binding site [chemical binding]; other site 398527005815 heterodimer interface [polypeptide binding]; other site 398527005816 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 398527005817 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 398527005818 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 398527005819 tetramer interface [polypeptide binding]; other site 398527005820 TPP-binding site [chemical binding]; other site 398527005821 heterodimer interface [polypeptide binding]; other site 398527005822 phosphorylation loop region [posttranslational modification] 398527005823 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 398527005824 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 398527005825 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527005826 Walker A motif; other site 398527005827 ATP binding site [chemical binding]; other site 398527005828 Walker B motif; other site 398527005829 arginine finger; other site 398527005830 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 398527005831 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 398527005832 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 398527005833 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 398527005834 dimer interface [polypeptide binding]; other site 398527005835 active site 398527005836 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 398527005837 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 398527005838 putative NAD(P) binding site [chemical binding]; other site 398527005839 active site 398527005840 putative substrate binding site [chemical binding]; other site 398527005841 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 398527005842 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 398527005843 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527005844 putative substrate translocation pore; other site 398527005845 putative aldolase; Validated; Region: PRK08130 398527005846 intersubunit interface [polypeptide binding]; other site 398527005847 active site 398527005848 Zn2+ binding site [ion binding]; other site 398527005849 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 398527005850 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 398527005851 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 398527005852 Transcriptional regulators [Transcription]; Region: FadR; COG2186 398527005853 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527005854 DNA-binding site [nucleotide binding]; DNA binding site 398527005855 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 398527005856 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 398527005857 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 398527005858 Bacterial transcriptional regulator; Region: IclR; pfam01614 398527005859 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527005860 metabolite-proton symporter; Region: 2A0106; TIGR00883 398527005861 putative substrate translocation pore; other site 398527005862 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 398527005863 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 398527005864 metal binding site [ion binding]; metal-binding site 398527005865 putative dimer interface [polypeptide binding]; other site 398527005866 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 398527005867 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527005868 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 398527005869 dimerization interface [polypeptide binding]; other site 398527005870 Guanylate kinase; Region: Guanylate_kin; pfam00625 398527005871 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 398527005872 active site 398527005873 putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223 398527005874 phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325 398527005875 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527005876 DNA-binding site [nucleotide binding]; DNA binding site 398527005877 UTRA domain; Region: UTRA; pfam07702 398527005878 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 398527005879 carbon-phosphorus lyase complex subunit; Validated; Region: phnH; PRK10147 398527005880 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 398527005881 Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007 398527005882 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 398527005883 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 398527005884 Walker A/P-loop; other site 398527005885 ATP binding site [chemical binding]; other site 398527005886 Q-loop/lid; other site 398527005887 ABC transporter signature motif; other site 398527005888 Walker B; other site 398527005889 D-loop; other site 398527005890 H-loop/switch region; other site 398527005891 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 398527005892 phosphonate C-P lyase system protein PhnL; Region: CP_lyasePhnL; TIGR02324 398527005893 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 398527005894 Walker A/P-loop; other site 398527005895 ATP binding site [chemical binding]; other site 398527005896 Q-loop/lid; other site 398527005897 ABC transporter signature motif; other site 398527005898 Walker B; other site 398527005899 D-loop; other site 398527005900 H-loop/switch region; other site 398527005901 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 398527005902 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 398527005903 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 398527005904 active site 398527005905 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 398527005906 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 398527005907 metal binding site [ion binding]; metal-binding site 398527005908 active site 398527005909 I-site; other site 398527005910 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 398527005911 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 398527005912 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 398527005913 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 398527005914 substrate binding pocket [chemical binding]; other site 398527005915 membrane-bound complex binding site; other site 398527005916 hinge residues; other site 398527005917 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 398527005918 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 398527005919 active site 398527005920 Zn binding site [ion binding]; other site 398527005921 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 398527005922 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 398527005923 trimer interface [polypeptide binding]; other site 398527005924 eyelet of channel; other site 398527005925 aldolase II superfamily protein; Provisional; Region: PRK07044 398527005926 active site 398527005927 intersubunit interface [polypeptide binding]; other site 398527005928 Zn2+ binding site [ion binding]; other site 398527005929 OsmC-like protein; Region: OsmC; pfam02566 398527005930 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 398527005931 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 398527005932 HlyD family secretion protein; Region: HlyD_3; pfam13437 398527005933 multidrug efflux protein; Reviewed; Region: PRK09579 398527005934 Phosphoesterase family; Region: Phosphoesterase; pfam04185 398527005935 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 398527005936 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 398527005937 substrate binding pocket [chemical binding]; other site 398527005938 membrane-bound complex binding site; other site 398527005939 hinge residues; other site 398527005940 Protein of unknown function (DUF3443); Region: DUF3443; pfam11925 398527005941 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 398527005942 homodimer interface [polypeptide binding]; other site 398527005943 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 398527005944 active site pocket [active] 398527005945 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527005946 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527005947 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 398527005948 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 398527005949 tetramer interface [polypeptide binding]; other site 398527005950 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527005951 catalytic residue [active] 398527005952 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 398527005953 Peptidase family M23; Region: Peptidase_M23; pfam01551 398527005954 Cupin domain; Region: Cupin_2; cl17218 398527005955 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 398527005956 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 398527005957 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 398527005958 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 398527005959 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 398527005960 S-adenosylmethionine binding site [chemical binding]; other site 398527005961 NAD-dependent deacetylase; Provisional; Region: PRK05333 398527005962 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 398527005963 Oxidoreductase-like protein, N-terminal; Region: Oxidored-like; pfam09791 398527005964 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 398527005965 classical (c) SDRs; Region: SDR_c; cd05233 398527005966 NAD(P) binding site [chemical binding]; other site 398527005967 active site 398527005968 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 398527005969 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 398527005970 NodB motif; other site 398527005971 active site 398527005972 catalytic site [active] 398527005973 metal binding site [ion binding]; metal-binding site 398527005974 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 398527005975 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 398527005976 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 398527005977 flagellar motor stator protein MotA; Region: MotA1; TIGR03818 398527005978 flagellar motor protein MotB; Validated; Region: motB; PRK09041 398527005979 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 398527005980 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 398527005981 ligand binding site [chemical binding]; other site 398527005982 CsbD-like; Region: CsbD; pfam05532 398527005983 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 398527005984 putative catalytic site [active] 398527005985 putative phosphate binding site [ion binding]; other site 398527005986 active site 398527005987 metal binding site A [ion binding]; metal-binding site 398527005988 DNA binding site [nucleotide binding] 398527005989 putative AP binding site [nucleotide binding]; other site 398527005990 putative metal binding site B [ion binding]; other site 398527005991 3HB-oligomer hydrolase (3HBOH); Region: 3HBOH; pfam10605 398527005992 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 398527005993 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 398527005994 catalytic loop [active] 398527005995 iron binding site [ion binding]; other site 398527005996 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 398527005997 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 398527005998 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 398527005999 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 398527006000 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 398527006001 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 398527006002 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 398527006003 Ligand binding site; other site 398527006004 metal-binding site 398527006005 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 398527006006 CoenzymeA binding site [chemical binding]; other site 398527006007 subunit interaction site [polypeptide binding]; other site 398527006008 PHB binding site; other site 398527006009 Domain of unknown function (DUF4130; Region: DUF4130; cl14836 398527006010 Domain of unknown function (DUF4130; Region: DUF4130; cl14836 398527006011 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 398527006012 Fe-S cluster binding site [ion binding]; other site 398527006013 active site 398527006014 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 398527006015 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12650 398527006016 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 398527006017 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 398527006018 catalytic residue [active] 398527006019 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 398527006020 phosphonopyruvate decarboxylase; Region: Ppyr-DeCO2ase; TIGR03297 398527006021 PYR/PP interface [polypeptide binding]; other site 398527006022 dimer interface [polypeptide binding]; other site 398527006023 TPP binding site [chemical binding]; other site 398527006024 Thiamine pyrophosphate (TPP) family, PpyrDC subfamily, TPP-binding module; composed of proteins similar to phosphonopyruvate decarboxylase (PpyrDC) proteins. PpyrDC is a homotrimeric enzyme which functions in the biosynthesis of C-P compounds such as...; Region: TPP_PpyrDC; cd03371 398527006025 TPP-binding site; other site 398527006026 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 398527006027 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 398527006028 tetramer interface [polypeptide binding]; other site 398527006029 active site 398527006030 Mg2+/Mn2+ binding site [ion binding]; other site 398527006031 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 398527006032 active site 398527006033 metal-binding site 398527006034 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 398527006035 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 398527006036 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 398527006037 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 398527006038 dimer interface [polypeptide binding]; other site 398527006039 putative CheW interface [polypeptide binding]; other site 398527006040 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 398527006041 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 398527006042 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 398527006043 Protein of unknown function, DUF484; Region: DUF484; cl17449 398527006044 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 398527006045 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 398527006046 metal binding site [ion binding]; metal-binding site 398527006047 active site 398527006048 I-site; other site 398527006049 Protein of unknown function (DUF2866); Region: DUF2866; pfam11065 398527006050 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 398527006051 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 398527006052 putative catalytic residue [active] 398527006053 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 398527006054 Uncharacterized conserved protein [Function unknown]; Region: COG1739 398527006055 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 398527006056 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 398527006057 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 398527006058 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 398527006059 trimer interface [polypeptide binding]; other site 398527006060 active site 398527006061 substrate binding site [chemical binding]; other site 398527006062 CoA binding site [chemical binding]; other site 398527006063 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 398527006064 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 398527006065 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 398527006066 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 398527006067 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 398527006068 putative ADP-binding pocket [chemical binding]; other site 398527006069 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 398527006070 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 398527006071 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 398527006072 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 398527006073 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 398527006074 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 398527006075 tyrosine kinase; Provisional; Region: PRK11519 398527006076 Chain length determinant protein; Region: Wzz; pfam02706 398527006077 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 398527006078 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 398527006079 Low molecular weight phosphatase family; Region: LMWPc; cd00115 398527006080 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 398527006081 active site 398527006082 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 398527006083 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 398527006084 SLBB domain; Region: SLBB; pfam10531 398527006085 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 398527006086 Bacterial sugar transferase; Region: Bac_transf; pfam02397 398527006087 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 398527006088 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 398527006089 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 398527006090 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 398527006091 Pseudomonas fluorescens 4-hydroxymuconic semialdehyde dehydrogenase-like; Region: ALDH_HMSADH_HapE; cd07115 398527006092 NAD(P) binding site [chemical binding]; other site 398527006093 catalytic residues [active] 398527006094 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527006095 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527006096 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 398527006097 putative dimerization interface [polypeptide binding]; other site 398527006098 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 398527006099 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527006100 putative substrate translocation pore; other site 398527006101 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527006102 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527006103 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 398527006104 putative dimerization interface [polypeptide binding]; other site 398527006105 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 398527006106 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 398527006107 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 398527006108 formyl-coenzyme A transferase; Provisional; Region: PRK05398 398527006109 CoA-transferase family III; Region: CoA_transf_3; pfam02515 398527006110 Transcriptional regulators [Transcription]; Region: GntR; COG1802 398527006111 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527006112 DNA-binding site [nucleotide binding]; DNA binding site 398527006113 FCD domain; Region: FCD; pfam07729 398527006114 shikimate transporter; Provisional; Region: PRK09952 398527006115 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527006116 putative substrate translocation pore; other site 398527006117 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 398527006118 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527006119 YadA-like C-terminal region; Region: YadA; pfam03895 398527006120 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 398527006121 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 398527006122 dimer interface [polypeptide binding]; other site 398527006123 phosphorylation site [posttranslational modification] 398527006124 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527006125 ATP binding site [chemical binding]; other site 398527006126 Mg2+ binding site [ion binding]; other site 398527006127 G-X-G motif; other site 398527006128 Protein of unknown function (DUF3830); Region: DUF3830; pfam12903 398527006129 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 398527006130 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527006131 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527006132 Autoinducer binding domain; Region: Autoind_bind; pfam03472 398527006133 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 398527006134 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 398527006135 DNA binding residues [nucleotide binding] 398527006136 dimerization interface [polypeptide binding]; other site 398527006137 amidase; Provisional; Region: PRK07486 398527006138 Amidase; Region: Amidase; pfam01425 398527006139 ABC-2 type transporter; Region: ABC2_membrane; cl17235 398527006140 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 398527006141 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 398527006142 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 398527006143 Walker A/P-loop; other site 398527006144 ATP binding site [chemical binding]; other site 398527006145 Q-loop/lid; other site 398527006146 ABC transporter signature motif; other site 398527006147 Walker B; other site 398527006148 D-loop; other site 398527006149 H-loop/switch region; other site 398527006150 Tannase and feruloyl esterase; Region: Tannase; pfam07519 398527006151 OpgC protein; Region: OpgC_C; pfam10129 398527006152 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 398527006153 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 398527006154 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527006155 Walker A motif; other site 398527006156 ATP binding site [chemical binding]; other site 398527006157 Walker B motif; other site 398527006158 arginine finger; other site 398527006159 Peptidase family M41; Region: Peptidase_M41; pfam01434 398527006160 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 398527006161 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 398527006162 FMN binding site [chemical binding]; other site 398527006163 substrate binding site [chemical binding]; other site 398527006164 putative catalytic residue [active] 398527006165 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 398527006166 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 398527006167 transmembrane helices; other site 398527006168 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527006169 sugar efflux transporter; Region: 2A0120; TIGR00899 398527006170 putative substrate translocation pore; other site 398527006171 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 398527006172 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 398527006173 active site 398527006174 metal binding site [ion binding]; metal-binding site 398527006175 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 398527006176 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 398527006177 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527006178 active site 398527006179 phosphorylation site [posttranslational modification] 398527006180 intermolecular recognition site; other site 398527006181 dimerization interface [polypeptide binding]; other site 398527006182 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527006183 Walker A motif; other site 398527006184 ATP binding site [chemical binding]; other site 398527006185 Walker B motif; other site 398527006186 arginine finger; other site 398527006187 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 398527006188 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 398527006189 dimer interface [polypeptide binding]; other site 398527006190 phosphorylation site [posttranslational modification] 398527006191 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527006192 ATP binding site [chemical binding]; other site 398527006193 Mg2+ binding site [ion binding]; other site 398527006194 G-X-G motif; other site 398527006195 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 398527006196 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 398527006197 active site 398527006198 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 398527006199 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 398527006200 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 398527006201 shikimate binding site; other site 398527006202 NAD(P) binding site [chemical binding]; other site 398527006203 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 398527006204 Walker A/P-loop; other site 398527006205 ATP binding site [chemical binding]; other site 398527006206 ABC transporter; Region: ABC_tran; pfam00005 398527006207 Q-loop/lid; other site 398527006208 ABC transporter signature motif; other site 398527006209 Walker B; other site 398527006210 D-loop; other site 398527006211 H-loop/switch region; other site 398527006212 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 398527006213 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 398527006214 putative NAD(P) binding site [chemical binding]; other site 398527006215 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 398527006216 GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914 398527006217 GDP-Fucose binding site [chemical binding]; other site 398527006218 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 398527006219 Tetratricopeptide repeat; Region: TPR_16; pfam13432 398527006220 binding surface 398527006221 TPR motif; other site 398527006222 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 398527006223 binding surface 398527006224 TPR motif; other site 398527006225 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 398527006226 binding surface 398527006227 Tetratricopeptide repeat; Region: TPR_16; pfam13432 398527006228 TPR motif; other site 398527006229 ADP-heptose:LPS heptosyl transferase I; Provisional; Region: PRK10964; cl15782 398527006230 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 398527006231 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 398527006232 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 398527006233 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 398527006234 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 398527006235 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 398527006236 metal-binding site [ion binding] 398527006237 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3544 398527006238 Cupin; Region: Cupin_6; pfam12852 398527006239 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527006240 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 398527006241 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527006242 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 398527006243 S-adenosylmethionine binding site [chemical binding]; other site 398527006244 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 398527006245 2-methylisocitrate dehydratase, Fe/S-dependent; Region: 2met_isocit_dHY; TIGR02333 398527006246 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 398527006247 substrate binding site [chemical binding]; other site 398527006248 ligand binding site [chemical binding]; other site 398527006249 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 398527006250 substrate binding site [chemical binding]; other site 398527006251 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 398527006252 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 398527006253 dimer interface [polypeptide binding]; other site 398527006254 active site 398527006255 citrylCoA binding site [chemical binding]; other site 398527006256 oxalacetate/citrate binding site [chemical binding]; other site 398527006257 coenzyme A binding site [chemical binding]; other site 398527006258 catalytic triad [active] 398527006259 Propionate catabolism activator; Region: PrpR_N; pfam06506 398527006260 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 398527006261 PAS domain; Region: PAS; smart00091 398527006262 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527006263 Walker A motif; other site 398527006264 ATP binding site [chemical binding]; other site 398527006265 Walker B motif; other site 398527006266 arginine finger; other site 398527006267 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 398527006268 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 398527006269 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527006270 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 398527006271 hydroxyglutarate oxidase; Provisional; Region: PRK11728 398527006272 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 398527006273 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 398527006274 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 398527006275 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 398527006276 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 398527006277 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 398527006278 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 398527006279 Walker A/P-loop; other site 398527006280 ATP binding site [chemical binding]; other site 398527006281 Q-loop/lid; other site 398527006282 ABC transporter signature motif; other site 398527006283 Walker B; other site 398527006284 D-loop; other site 398527006285 H-loop/switch region; other site 398527006286 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 398527006287 Walker A/P-loop; other site 398527006288 ATP binding site [chemical binding]; other site 398527006289 Q-loop/lid; other site 398527006290 ABC transporter signature motif; other site 398527006291 Walker B; other site 398527006292 D-loop; other site 398527006293 H-loop/switch region; other site 398527006294 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 398527006295 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 398527006296 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527006297 dimer interface [polypeptide binding]; other site 398527006298 conserved gate region; other site 398527006299 ABC-ATPase subunit interface; other site 398527006300 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 398527006301 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527006302 dimer interface [polypeptide binding]; other site 398527006303 conserved gate region; other site 398527006304 putative PBP binding loops; other site 398527006305 ABC-ATPase subunit interface; other site 398527006306 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 398527006307 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 398527006308 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 398527006309 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 398527006310 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 398527006311 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 398527006312 motif II; other site 398527006313 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 398527006314 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 398527006315 Coenzyme A binding pocket [chemical binding]; other site 398527006316 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 398527006317 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 398527006318 putative ligand binding site [chemical binding]; other site 398527006319 NAD binding site [chemical binding]; other site 398527006320 dimerization interface [polypeptide binding]; other site 398527006321 catalytic site [active] 398527006322 hypothetical protein; Provisional; Region: PRK05965 398527006323 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 398527006324 inhibitor-cofactor binding pocket; inhibition site 398527006325 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527006326 catalytic residue [active] 398527006327 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 398527006328 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 398527006329 putative DNA binding site [nucleotide binding]; other site 398527006330 putative Zn2+ binding site [ion binding]; other site 398527006331 AsnC family; Region: AsnC_trans_reg; pfam01037 398527006332 transcriptional activator TtdR; Provisional; Region: PRK09801 398527006333 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527006334 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 398527006335 putative effector binding pocket; other site 398527006336 putative dimerization interface [polypeptide binding]; other site 398527006337 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 398527006338 tartrate dehydrogenase; Region: TTC; TIGR02089 398527006339 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 398527006340 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 398527006341 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 398527006342 trimer interface [polypeptide binding]; other site 398527006343 eyelet of channel; other site 398527006344 benzoate transport; Region: 2A0115; TIGR00895 398527006345 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527006346 putative substrate translocation pore; other site 398527006347 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527006348 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 398527006349 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 398527006350 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 398527006351 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 398527006352 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 398527006353 Protein of unknown function (DUF3380); Region: DUF3380; pfam11860 398527006354 succinic semialdehyde dehydrogenase; Region: PLN02278 398527006355 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 398527006356 tetramerization interface [polypeptide binding]; other site 398527006357 NAD(P) binding site [chemical binding]; other site 398527006358 catalytic residues [active] 398527006359 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527006360 metabolite-proton symporter; Region: 2A0106; TIGR00883 398527006361 putative substrate translocation pore; other site 398527006362 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 398527006363 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 398527006364 active site 398527006365 Flavin Reductases; Region: FlaRed; cl00801 398527006366 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527006367 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527006368 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 398527006369 substrate binding pocket [chemical binding]; other site 398527006370 dimerization interface [polypeptide binding]; other site 398527006371 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 398527006372 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527006373 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 398527006374 dimerization interface [polypeptide binding]; other site 398527006375 substrate binding pocket [chemical binding]; other site 398527006376 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 398527006377 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527006378 putative substrate translocation pore; other site 398527006379 Amidohydrolase; Region: Amidohydro_2; pfam04909 398527006380 hypothetical protein; Validated; Region: PRK06201 398527006381 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 398527006382 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 398527006383 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527006384 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 398527006385 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527006386 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 398527006387 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 398527006388 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 398527006389 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527006390 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 398527006391 dimerization interface [polypeptide binding]; other site 398527006392 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 398527006393 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 398527006394 DNA binding site [nucleotide binding] 398527006395 Predicted ATPase [General function prediction only]; Region: COG3903 398527006396 Domain of unknown function (DUF3331); Region: DUF3331; pfam11811 398527006397 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 398527006398 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 398527006399 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 398527006400 ligand binding site [chemical binding]; other site 398527006401 flexible hinge region; other site 398527006402 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 398527006403 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 398527006404 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 398527006405 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 398527006406 Protein of unknown function (DUF1427); Region: DUF1427; pfam07235 398527006407 HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401 398527006408 Mechanosensitive ion channel; Region: MS_channel; pfam00924 398527006409 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 398527006410 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 398527006411 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 398527006412 ligand binding site [chemical binding]; other site 398527006413 flexible hinge region; other site 398527006414 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 398527006415 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 398527006416 active site 398527006417 Isochorismatase family; Region: Isochorismatase; pfam00857 398527006418 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 398527006419 catalytic triad [active] 398527006420 dimer interface [polypeptide binding]; other site 398527006421 conserved cis-peptide bond; other site 398527006422 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 398527006423 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 398527006424 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 398527006425 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527006426 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 398527006427 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527006428 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 398527006429 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 398527006430 DNA binding site [nucleotide binding] 398527006431 AAA ATPase domain; Region: AAA_16; pfam13191 398527006432 Predicted ATPase [General function prediction only]; Region: COG3903 398527006433 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527006434 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 398527006435 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 398527006436 dimerization interface [polypeptide binding]; other site 398527006437 substrate binding pocket [chemical binding]; other site 398527006438 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 398527006439 TPP-binding site [chemical binding]; other site 398527006440 dimer interface [polypeptide binding]; other site 398527006441 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 398527006442 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 398527006443 PYR/PP interface [polypeptide binding]; other site 398527006444 dimer interface [polypeptide binding]; other site 398527006445 TPP binding site [chemical binding]; other site 398527006446 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 398527006447 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 398527006448 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 398527006449 NAD(P) binding site [chemical binding]; other site 398527006450 active site 398527006451 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 398527006452 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 398527006453 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 398527006454 DctM-like transporters; Region: DctM; pfam06808 398527006455 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 398527006456 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 398527006457 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 398527006458 TPP-binding site [chemical binding]; other site 398527006459 dimer interface [polypeptide binding]; other site 398527006460 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 398527006461 PYR/PP interface [polypeptide binding]; other site 398527006462 dimer interface [polypeptide binding]; other site 398527006463 TPP binding site [chemical binding]; other site 398527006464 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 398527006465 glycerate dehydrogenase; Provisional; Region: PRK06932 398527006466 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 398527006467 putative ligand binding site [chemical binding]; other site 398527006468 putative NAD binding site [chemical binding]; other site 398527006469 catalytic site [active] 398527006470 short chain dehydrogenase; Provisional; Region: PRK06500 398527006471 classical (c) SDRs; Region: SDR_c; cd05233 398527006472 NAD(P) binding site [chemical binding]; other site 398527006473 active site 398527006474 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 398527006475 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 398527006476 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 398527006477 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 398527006478 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527006479 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 398527006480 dimerization interface [polypeptide binding]; other site 398527006481 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 398527006482 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 398527006483 Walker A/P-loop; other site 398527006484 ATP binding site [chemical binding]; other site 398527006485 Q-loop/lid; other site 398527006486 ABC transporter signature motif; other site 398527006487 Walker B; other site 398527006488 D-loop; other site 398527006489 H-loop/switch region; other site 398527006490 TOBE domain; Region: TOBE_2; pfam08402 398527006491 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 398527006492 Haloacid dehalogenase superfamily, subfamily IA, variant 2 with 3rd motif like haloacid dehalogenase; Region: HAD-SF-IA-v2; TIGR01493 398527006493 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 398527006494 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 398527006495 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527006496 dimer interface [polypeptide binding]; other site 398527006497 conserved gate region; other site 398527006498 putative PBP binding loops; other site 398527006499 ABC-ATPase subunit interface; other site 398527006500 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 398527006501 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527006502 dimer interface [polypeptide binding]; other site 398527006503 conserved gate region; other site 398527006504 putative PBP binding loops; other site 398527006505 ABC-ATPase subunit interface; other site 398527006506 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 398527006507 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 398527006508 NAD binding site [chemical binding]; other site 398527006509 catalytic residues [active] 398527006510 choline dehydrogenase; Validated; Region: PRK02106 398527006511 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 398527006512 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 398527006513 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 398527006514 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 398527006515 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 398527006516 substrate binding pocket [chemical binding]; other site 398527006517 membrane-bound complex binding site; other site 398527006518 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 398527006519 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 398527006520 substrate binding pocket [chemical binding]; other site 398527006521 membrane-bound complex binding site; other site 398527006522 hinge residues; other site 398527006523 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 398527006524 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 398527006525 C-terminal domain interface [polypeptide binding]; other site 398527006526 GSH binding site (G-site) [chemical binding]; other site 398527006527 dimer interface [polypeptide binding]; other site 398527006528 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 398527006529 dimer interface [polypeptide binding]; other site 398527006530 N-terminal domain interface [polypeptide binding]; other site 398527006531 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 398527006532 GAF domain; Region: GAF; pfam01590 398527006533 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527006534 Walker A motif; other site 398527006535 ATP binding site [chemical binding]; other site 398527006536 Walker B motif; other site 398527006537 arginine finger; other site 398527006538 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 398527006539 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 398527006540 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 398527006541 heme-binding site [chemical binding]; other site 398527006542 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 398527006543 FAD binding pocket [chemical binding]; other site 398527006544 FAD binding motif [chemical binding]; other site 398527006545 phosphate binding motif [ion binding]; other site 398527006546 beta-alpha-beta structure motif; other site 398527006547 NAD binding pocket [chemical binding]; other site 398527006548 Heme binding pocket [chemical binding]; other site 398527006549 phasin family protein; Region: phasin; TIGR01841 398527006550 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 398527006551 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 398527006552 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 398527006553 NAD(P) binding site [chemical binding]; other site 398527006554 active site 398527006555 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 398527006556 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527006557 DNA-binding site [nucleotide binding]; DNA binding site 398527006558 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 398527006559 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527006560 homodimer interface [polypeptide binding]; other site 398527006561 catalytic residue [active] 398527006562 Low affinity iron permease; Region: Iron_permease; pfam04120 398527006563 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 398527006564 Uncharacterized conserved protein [Function unknown]; Region: COG5476 398527006565 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 398527006566 MlrC C-terminus; Region: MlrC_C; pfam07171 398527006567 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527006568 D-galactonate transporter; Region: 2A0114; TIGR00893 398527006569 putative substrate translocation pore; other site 398527006570 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527006571 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527006572 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 398527006573 dimerization interface [polypeptide binding]; other site 398527006574 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 398527006575 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 398527006576 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 398527006577 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 398527006578 DNA binding residues [nucleotide binding] 398527006579 dimerization interface [polypeptide binding]; other site 398527006580 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 398527006581 homodimer interface [polypeptide binding]; other site 398527006582 homotetramer interface [polypeptide binding]; other site 398527006583 active site pocket [active] 398527006584 cleavage site 398527006585 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 398527006586 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 398527006587 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 398527006588 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 398527006589 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527006590 ATP binding site [chemical binding]; other site 398527006591 Mg2+ binding site [ion binding]; other site 398527006592 G-X-G motif; other site 398527006593 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 398527006594 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 398527006595 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 398527006596 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 398527006597 Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454 398527006598 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527006599 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527006600 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 398527006601 putative effector binding pocket; other site 398527006602 dimerization interface [polypeptide binding]; other site 398527006603 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 398527006604 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527006605 DNA-binding site [nucleotide binding]; DNA binding site 398527006606 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 398527006607 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527006608 homodimer interface [polypeptide binding]; other site 398527006609 catalytic residue [active] 398527006610 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 398527006611 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 398527006612 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 398527006613 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 398527006614 Clp amino terminal domain; Region: Clp_N; pfam02861 398527006615 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527006616 Walker A motif; other site 398527006617 ATP binding site [chemical binding]; other site 398527006618 Walker B motif; other site 398527006619 arginine finger; other site 398527006620 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527006621 Walker A motif; other site 398527006622 ATP binding site [chemical binding]; other site 398527006623 Walker B motif; other site 398527006624 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 398527006625 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 398527006626 Protein required for attachment to host cells; Region: Host_attach; pfam10116 398527006627 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 398527006628 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527006629 putative substrate translocation pore; other site 398527006630 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527006631 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527006632 LysR substrate binding domain; Region: LysR_substrate; pfam03466 398527006633 dimerization interface [polypeptide binding]; other site 398527006634 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 398527006635 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 398527006636 putative NAD(P) binding site [chemical binding]; other site 398527006637 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 398527006638 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527006639 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 398527006640 DNA-binding site [nucleotide binding]; DNA binding site 398527006641 FCD domain; Region: FCD; pfam07729 398527006642 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527006643 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527006644 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 398527006645 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 398527006646 Domain of unknown function (DUF336); Region: DUF336; pfam03928 398527006647 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 398527006648 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 398527006649 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 398527006650 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 398527006651 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 398527006652 Cytochrome c; Region: Cytochrom_C; pfam00034 398527006653 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 398527006654 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 398527006655 trimer interface [polypeptide binding]; other site 398527006656 eyelet of channel; other site 398527006657 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 398527006658 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 398527006659 NAD(P) binding site [chemical binding]; other site 398527006660 active site 398527006661 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527006662 D-galactonate transporter; Region: 2A0114; TIGR00893 398527006663 putative substrate translocation pore; other site 398527006664 putative sialic acid transporter; Region: 2A0112; TIGR00891 398527006665 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527006666 putative substrate translocation pore; other site 398527006667 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 398527006668 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527006669 DNA-binding site [nucleotide binding]; DNA binding site 398527006670 FCD domain; Region: FCD; pfam07729 398527006671 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 398527006672 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 398527006673 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527006674 DNA-binding site [nucleotide binding]; DNA binding site 398527006675 UTRA domain; Region: UTRA; pfam07702 398527006676 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 398527006677 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 398527006678 active site 398527006679 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527006680 D-galactonate transporter; Region: 2A0114; TIGR00893 398527006681 putative substrate translocation pore; other site 398527006682 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 398527006683 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 398527006684 Mechanosensitive ion channel; Region: MS_channel; pfam00924 398527006685 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_6; cd07824 398527006686 putative hydrophobic ligand binding site [chemical binding]; other site 398527006687 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 398527006688 MarR family; Region: MarR_2; pfam12802 398527006689 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 398527006690 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 398527006691 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 398527006692 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 398527006693 TM-ABC transporter signature motif; other site 398527006694 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 398527006695 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 398527006696 Walker A/P-loop; other site 398527006697 ATP binding site [chemical binding]; other site 398527006698 Q-loop/lid; other site 398527006699 ABC transporter signature motif; other site 398527006700 Walker B; other site 398527006701 D-loop; other site 398527006702 H-loop/switch region; other site 398527006703 Chromate transporter; Region: Chromate_transp; pfam02417 398527006704 Chromate transporter; Region: Chromate_transp; pfam02417 398527006705 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 398527006706 The Death Domain Superfamily of protein-protein interaction domains; Region: DD_superfamily; cl14633 398527006707 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 398527006708 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 398527006709 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527006710 active site 398527006711 phosphorylation site [posttranslational modification] 398527006712 intermolecular recognition site; other site 398527006713 dimerization interface [polypeptide binding]; other site 398527006714 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 398527006715 DNA binding residues [nucleotide binding] 398527006716 dimerization interface [polypeptide binding]; other site 398527006717 Response regulator receiver domain; Region: Response_reg; pfam00072 398527006718 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527006719 active site 398527006720 phosphorylation site [posttranslational modification] 398527006721 intermolecular recognition site; other site 398527006722 dimerization interface [polypeptide binding]; other site 398527006723 PAS domain S-box; Region: sensory_box; TIGR00229 398527006724 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 398527006725 putative active site [active] 398527006726 heme pocket [chemical binding]; other site 398527006727 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 398527006728 Histidine kinase; Region: HisKA_3; pfam07730 398527006729 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527006730 ATP binding site [chemical binding]; other site 398527006731 Mg2+ binding site [ion binding]; other site 398527006732 G-X-G motif; other site 398527006733 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 398527006734 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 398527006735 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 398527006736 dimer interface [polypeptide binding]; other site 398527006737 phosphorylation site [posttranslational modification] 398527006738 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527006739 ATP binding site [chemical binding]; other site 398527006740 Mg2+ binding site [ion binding]; other site 398527006741 G-X-G motif; other site 398527006742 Response regulator receiver domain; Region: Response_reg; pfam00072 398527006743 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527006744 active site 398527006745 phosphorylation site [posttranslational modification] 398527006746 intermolecular recognition site; other site 398527006747 dimerization interface [polypeptide binding]; other site 398527006748 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 398527006749 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 398527006750 putative active site [active] 398527006751 heme pocket [chemical binding]; other site 398527006752 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 398527006753 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 398527006754 putative active site [active] 398527006755 heme pocket [chemical binding]; other site 398527006756 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 398527006757 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 398527006758 putative active site [active] 398527006759 heme pocket [chemical binding]; other site 398527006760 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 398527006761 putative active site [active] 398527006762 heme pocket [chemical binding]; other site 398527006763 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 398527006764 Histidine kinase; Region: HisKA_3; pfam07730 398527006765 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527006766 ATP binding site [chemical binding]; other site 398527006767 Mg2+ binding site [ion binding]; other site 398527006768 G-X-G motif; other site 398527006769 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527006770 D-galactonate transporter; Region: 2A0114; TIGR00893 398527006771 putative substrate translocation pore; other site 398527006772 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 398527006773 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 398527006774 inhibitor site; inhibition site 398527006775 active site 398527006776 dimer interface [polypeptide binding]; other site 398527006777 catalytic residue [active] 398527006778 Transcriptional regulators [Transcription]; Region: PurR; COG1609 398527006779 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 398527006780 DNA binding site [nucleotide binding] 398527006781 domain linker motif; other site 398527006782 This group includes the ligand-binding domain of putative DNA transcription repressors which are highly similar to that of the repressor specific for gluconate (GntR), a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_1; cd06273 398527006783 putative ligand binding site [chemical binding]; other site 398527006784 putative dimerization interface [polypeptide binding]; other site 398527006785 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 398527006786 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527006787 ATP binding site [chemical binding]; other site 398527006788 Mg2+ binding site [ion binding]; other site 398527006789 G-X-G motif; other site 398527006790 Response regulator receiver domain; Region: Response_reg; pfam00072 398527006791 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527006792 active site 398527006793 phosphorylation site [posttranslational modification] 398527006794 intermolecular recognition site; other site 398527006795 dimerization interface [polypeptide binding]; other site 398527006796 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 398527006797 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527006798 active site 398527006799 phosphorylation site [posttranslational modification] 398527006800 intermolecular recognition site; other site 398527006801 dimerization interface [polypeptide binding]; other site 398527006802 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 398527006803 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 398527006804 active site 398527006805 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 398527006806 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 398527006807 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527006808 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527006809 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 398527006810 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 398527006811 conserved cys residue [active] 398527006812 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527006813 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527006814 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 398527006815 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 398527006816 NADP binding site [chemical binding]; other site 398527006817 active site 398527006818 putative substrate binding site [chemical binding]; other site 398527006819 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 398527006820 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 398527006821 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 398527006822 substrate binding site; other site 398527006823 tetramer interface; other site 398527006824 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 398527006825 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 398527006826 NAD binding site [chemical binding]; other site 398527006827 substrate binding site [chemical binding]; other site 398527006828 homodimer interface [polypeptide binding]; other site 398527006829 active site 398527006830 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527006831 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 398527006832 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527006833 KpsF/GutQ family protein; Region: kpsF; TIGR00393 398527006834 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 398527006835 putative active site [active] 398527006836 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 398527006837 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 398527006838 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 398527006839 Ligand binding site; other site 398527006840 oligomer interface; other site 398527006841 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 398527006842 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 398527006843 active site 398527006844 motif I; other site 398527006845 motif II; other site 398527006846 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK12457 398527006847 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 398527006848 tyrosine kinase; Provisional; Region: PRK11519 398527006849 Chain length determinant protein; Region: Wzz; pfam02706 398527006850 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 398527006851 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 398527006852 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 398527006853 Low molecular weight phosphatase family; Region: LMWPc; cd00115 398527006854 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 398527006855 active site 398527006856 polysaccharide export protein Wza; Provisional; Region: PRK15078 398527006857 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 398527006858 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 398527006859 Bacterial sugar transferase; Region: Bac_transf; pfam02397 398527006860 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 398527006861 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 398527006862 NAD(P) binding site [chemical binding]; other site 398527006863 active site 398527006864 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 398527006865 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 398527006866 active site 398527006867 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 398527006868 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 398527006869 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 398527006870 putative lipopolysaccharide biosynthesis O-acetyl transferase WbbJ; Provisional; Region: PRK09677 398527006871 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 398527006872 trimer interface [polypeptide binding]; other site 398527006873 active site 398527006874 substrate binding site [chemical binding]; other site 398527006875 CoA binding site [chemical binding]; other site 398527006876 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 398527006877 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 398527006878 Substrate binding site; other site 398527006879 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 398527006880 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 398527006881 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 398527006882 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 398527006883 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 398527006884 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 398527006885 conserved cys residue [active] 398527006886 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527006887 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527006888 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 398527006889 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 398527006890 active site 398527006891 tetramer interface; other site 398527006892 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 398527006893 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 398527006894 hypothetical protein; Provisional; Region: PRK11667 398527006895 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527006896 D-galactonate transporter; Region: 2A0114; TIGR00893 398527006897 putative substrate translocation pore; other site 398527006898 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 398527006899 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527006900 putative substrate translocation pore; other site 398527006901 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 398527006902 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 398527006903 active site 398527006904 tetramer interface [polypeptide binding]; other site 398527006905 Transcriptional regulators [Transcription]; Region: GntR; COG1802 398527006906 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527006907 DNA-binding site [nucleotide binding]; DNA binding site 398527006908 FCD domain; Region: FCD; pfam07729 398527006909 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 398527006910 conserved cys residue [active] 398527006911 Predicted acetyltransferase [General function prediction only]; Region: COG3393 398527006912 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 398527006913 Coenzyme A binding pocket [chemical binding]; other site 398527006914 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 398527006915 exosortase A system-associated hydrolase 1; Region: hydr1_PEP; TIGR03100 398527006916 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 398527006917 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 398527006918 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527006919 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527006920 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 398527006921 dimerization interface [polypeptide binding]; other site 398527006922 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 398527006923 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527006924 dimer interface [polypeptide binding]; other site 398527006925 conserved gate region; other site 398527006926 putative PBP binding loops; other site 398527006927 ABC-ATPase subunit interface; other site 398527006928 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 398527006929 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527006930 dimer interface [polypeptide binding]; other site 398527006931 conserved gate region; other site 398527006932 putative PBP binding loops; other site 398527006933 ABC-ATPase subunit interface; other site 398527006934 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 398527006935 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 398527006936 Walker A/P-loop; other site 398527006937 ATP binding site [chemical binding]; other site 398527006938 Q-loop/lid; other site 398527006939 ABC transporter signature motif; other site 398527006940 Walker B; other site 398527006941 D-loop; other site 398527006942 H-loop/switch region; other site 398527006943 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 398527006944 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 398527006945 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 398527006946 Walker A/P-loop; other site 398527006947 ATP binding site [chemical binding]; other site 398527006948 Q-loop/lid; other site 398527006949 ABC transporter signature motif; other site 398527006950 Walker B; other site 398527006951 D-loop; other site 398527006952 H-loop/switch region; other site 398527006953 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 398527006954 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 398527006955 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 398527006956 Predicted acyl esterases [General function prediction only]; Region: COG2936 398527006957 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 398527006958 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 398527006959 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 398527006960 trimer interface [polypeptide binding]; other site 398527006961 eyelet of channel; other site 398527006962 D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178 398527006963 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 398527006964 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 398527006965 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 398527006966 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527006967 dimer interface [polypeptide binding]; other site 398527006968 conserved gate region; other site 398527006969 putative PBP binding loops; other site 398527006970 ABC-ATPase subunit interface; other site 398527006971 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 398527006972 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527006973 dimer interface [polypeptide binding]; other site 398527006974 conserved gate region; other site 398527006975 putative PBP binding loops; other site 398527006976 ABC-ATPase subunit interface; other site 398527006977 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 398527006978 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 398527006979 Walker A/P-loop; other site 398527006980 ATP binding site [chemical binding]; other site 398527006981 Q-loop/lid; other site 398527006982 ABC transporter signature motif; other site 398527006983 Walker B; other site 398527006984 D-loop; other site 398527006985 H-loop/switch region; other site 398527006986 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 398527006987 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 398527006988 Walker A/P-loop; other site 398527006989 ATP binding site [chemical binding]; other site 398527006990 Q-loop/lid; other site 398527006991 ABC transporter signature motif; other site 398527006992 Walker B; other site 398527006993 D-loop; other site 398527006994 H-loop/switch region; other site 398527006995 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 398527006996 FOG: CBS domain [General function prediction only]; Region: COG0517 398527006997 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 398527006998 BON domain; Region: BON; pfam04972 398527006999 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 398527007000 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 398527007001 Chromate transporter; Region: Chromate_transp; pfam02417 398527007002 myosin-cross-reactive antigen; Provisional; Region: PRK13977 398527007003 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 398527007004 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 398527007005 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 398527007006 Ligand Binding Site [chemical binding]; other site 398527007007 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 398527007008 Ligand Binding Site [chemical binding]; other site 398527007009 PAS domain S-box; Region: sensory_box; TIGR00229 398527007010 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 398527007011 putative active site [active] 398527007012 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 398527007013 heme pocket [chemical binding]; other site 398527007014 Histidine kinase; Region: HisKA_3; pfam07730 398527007015 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527007016 ATP binding site [chemical binding]; other site 398527007017 Mg2+ binding site [ion binding]; other site 398527007018 G-X-G motif; other site 398527007019 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 398527007020 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527007021 active site 398527007022 phosphorylation site [posttranslational modification] 398527007023 intermolecular recognition site; other site 398527007024 dimerization interface [polypeptide binding]; other site 398527007025 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 398527007026 DNA binding residues [nucleotide binding] 398527007027 dimerization interface [polypeptide binding]; other site 398527007028 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 398527007029 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527007030 active site 398527007031 phosphorylation site [posttranslational modification] 398527007032 intermolecular recognition site; other site 398527007033 dimerization interface [polypeptide binding]; other site 398527007034 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 398527007035 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 398527007036 ligand binding site [chemical binding]; other site 398527007037 flexible hinge region; other site 398527007038 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 398527007039 putative switch regulator; other site 398527007040 non-specific DNA interactions [nucleotide binding]; other site 398527007041 DNA binding site [nucleotide binding] 398527007042 sequence specific DNA binding site [nucleotide binding]; other site 398527007043 putative cAMP binding site [chemical binding]; other site 398527007044 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 398527007045 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 398527007046 putative NAD(P) binding site [chemical binding]; other site 398527007047 putative substrate binding site [chemical binding]; other site 398527007048 catalytic Zn binding site [ion binding]; other site 398527007049 structural Zn binding site [ion binding]; other site 398527007050 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 398527007051 Cytochrome c; Region: Cytochrom_C; cl11414 398527007052 Protein of unknown function (DUF3564); Region: DUF3564; pfam12087 398527007053 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 398527007054 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 398527007055 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 398527007056 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 398527007057 HSP70 interaction site [polypeptide binding]; other site 398527007058 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 398527007059 substrate binding site [polypeptide binding]; other site 398527007060 dimer interface [polypeptide binding]; other site 398527007061 Malonate transporter MadL subunit; Region: MadL; cl04273 398527007062 malonate transporter, MadM subunit; Region: malonate_madM; TIGR00808 398527007063 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527007064 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527007065 The C-terminal substrate-binding domian of LysR-type transcriptional regulator MdcR, which involved in the malonate catabolism contains the type 2 periplasmic binding fold; Region: PBP2_MdcR; cd08416 398527007066 putative dimerization interface [polypeptide binding]; other site 398527007067 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 398527007068 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 398527007069 ATP binding site [chemical binding]; other site 398527007070 putative Mg++ binding site [ion binding]; other site 398527007071 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 398527007072 nucleotide binding region [chemical binding]; other site 398527007073 ATP-binding site [chemical binding]; other site 398527007074 Protein of unknown function DUF72; Region: DUF72; pfam01904 398527007075 Cupin; Region: Cupin_6; pfam12852 398527007076 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 398527007077 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527007078 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527007079 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 398527007080 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 398527007081 NADP binding site [chemical binding]; other site 398527007082 active site 398527007083 steroid binding site; other site 398527007084 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 398527007085 C factor cell-cell signaling protein; Provisional; Region: PRK09009 398527007086 NADP binding site [chemical binding]; other site 398527007087 substrate binding site [chemical binding]; other site 398527007088 active site 398527007089 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 398527007090 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 398527007091 PYR/PP interface [polypeptide binding]; other site 398527007092 dimer interface [polypeptide binding]; other site 398527007093 TPP binding site [chemical binding]; other site 398527007094 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 398527007095 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 398527007096 TPP-binding site [chemical binding]; other site 398527007097 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 398527007098 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 398527007099 dimer interface [polypeptide binding]; other site 398527007100 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 398527007101 putative CheW interface [polypeptide binding]; other site 398527007102 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 398527007103 HetN oxidoreductase-like, classical (c) SDR; Region: HetN_like_SDR_c; cd08932 398527007104 putative NAD(P) binding site [chemical binding]; other site 398527007105 active site 398527007106 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 398527007107 hydroxyglutarate oxidase; Provisional; Region: PRK11728 398527007108 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 398527007109 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527007110 dimer interface [polypeptide binding]; other site 398527007111 conserved gate region; other site 398527007112 putative PBP binding loops; other site 398527007113 ABC-ATPase subunit interface; other site 398527007114 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 398527007115 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 398527007116 substrate binding pocket [chemical binding]; other site 398527007117 membrane-bound complex binding site; other site 398527007118 hinge residues; other site 398527007119 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 398527007120 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 398527007121 Walker A/P-loop; other site 398527007122 ATP binding site [chemical binding]; other site 398527007123 Q-loop/lid; other site 398527007124 ABC transporter signature motif; other site 398527007125 Walker B; other site 398527007126 D-loop; other site 398527007127 H-loop/switch region; other site 398527007128 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 398527007129 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 398527007130 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 398527007131 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527007132 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 398527007133 putative dimerization interface [polypeptide binding]; other site 398527007134 rod shape-determining protein MreB; Provisional; Region: PRK13930 398527007135 MreB and similar proteins; Region: MreB_like; cd10225 398527007136 nucleotide binding site [chemical binding]; other site 398527007137 Mg binding site [ion binding]; other site 398527007138 putative protofilament interaction site [polypeptide binding]; other site 398527007139 RodZ interaction site [polypeptide binding]; other site 398527007140 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 398527007141 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 398527007142 Ligand binding site [chemical binding]; other site 398527007143 Electron transfer flavoprotein domain; Region: ETF; pfam01012 398527007144 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 398527007145 putative ligand binding site [chemical binding]; other site 398527007146 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 398527007147 putative NAD binding site [chemical binding]; other site 398527007148 catalytic site [active] 398527007149 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 398527007150 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 398527007151 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 398527007152 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 398527007153 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 398527007154 MOSC domain; Region: MOSC; pfam03473 398527007155 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298 398527007156 active site 398527007157 Protein of unknown function (DUF3047); Region: DUF3047; pfam11249 398527007158 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 398527007159 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 398527007160 Na binding site [ion binding]; other site 398527007161 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 398527007162 agmatinase; Region: agmatinase; TIGR01230 398527007163 oligomer interface [polypeptide binding]; other site 398527007164 putative active site [active] 398527007165 Mn binding site [ion binding]; other site 398527007166 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527007167 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527007168 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 398527007169 dimerization interface [polypeptide binding]; other site 398527007170 Protein of unknown function (DUF1504); Region: DUF1504; pfam07399 398527007171 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 398527007172 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 398527007173 putative ion selectivity filter; other site 398527007174 putative pore gating glutamate residue; other site 398527007175 putative H+/Cl- coupling transport residue; other site 398527007176 Domain of unknown function (DUF4396); Region: DUF4396; pfam14342 398527007177 Transcriptional regulators [Transcription]; Region: MarR; COG1846 398527007178 MarR family; Region: MarR_2; pfam12802 398527007179 Domain of unknown function (DUF1840); Region: DUF1840; pfam08895 398527007180 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 398527007181 Ligand Binding Site [chemical binding]; other site 398527007182 hypothetical protein; Provisional; Region: PRK10316 398527007183 YfdX protein; Region: YfdX; pfam10938 398527007184 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 398527007185 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 398527007186 short chain dehydrogenase; Provisional; Region: PRK07109 398527007187 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 398527007188 putative NAD(P) binding site [chemical binding]; other site 398527007189 active site 398527007190 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 398527007191 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 398527007192 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 398527007193 [2Fe-2S] cluster binding site [ion binding]; other site 398527007194 thiamine pyrophosphate protein; Provisional; Region: PRK08273 398527007195 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 398527007196 PYR/PP interface [polypeptide binding]; other site 398527007197 dimer interface [polypeptide binding]; other site 398527007198 tetramer interface [polypeptide binding]; other site 398527007199 TPP binding site [chemical binding]; other site 398527007200 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 398527007201 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 398527007202 TPP-binding site [chemical binding]; other site 398527007203 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 3. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_3; cd03328 398527007204 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 398527007205 putative active site pocket [active] 398527007206 putative metal binding site [ion binding]; other site 398527007207 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 398527007208 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 398527007209 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 398527007210 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 398527007211 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 398527007212 DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990 398527007213 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527007214 DNA-binding site [nucleotide binding]; DNA binding site 398527007215 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 398527007216 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 398527007217 FAD binding domain; Region: FAD_binding_4; pfam01565 398527007218 FAD binding domain; Region: FAD_binding_4; pfam01565 398527007219 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 398527007220 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 398527007221 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 398527007222 Cysteine-rich domain; Region: CCG; pfam02754 398527007223 Cysteine-rich domain; Region: CCG; pfam02754 398527007224 Domain of unknown function (DUF336); Region: DUF336; cl01249 398527007225 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 398527007226 active site 398527007227 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 398527007228 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 398527007229 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 398527007230 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 398527007231 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 398527007232 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 398527007233 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 398527007234 NAD binding site [chemical binding]; other site 398527007235 ligand binding site [chemical binding]; other site 398527007236 catalytic site [active] 398527007237 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 398527007238 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 398527007239 phosphate binding site [ion binding]; other site 398527007240 dihydroxy-acid dehydratase; Provisional; Region: PRK13017 398527007241 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 398527007242 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 398527007243 trimer interface [polypeptide binding]; other site 398527007244 eyelet of channel; other site 398527007245 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527007246 metabolite-proton symporter; Region: 2A0106; TIGR00883 398527007247 putative substrate translocation pore; other site 398527007248 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 398527007249 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 398527007250 trimer interface [polypeptide binding]; other site 398527007251 eyelet of channel; other site 398527007252 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 398527007253 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 398527007254 dimerization interface [polypeptide binding]; other site 398527007255 ligand binding site [chemical binding]; other site 398527007256 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527007257 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527007258 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 398527007259 dimerization interface [polypeptide binding]; other site 398527007260 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 398527007261 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 398527007262 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 398527007263 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 398527007264 catalytic residue [active] 398527007265 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 398527007266 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 398527007267 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 398527007268 TM-ABC transporter signature motif; other site 398527007269 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 398527007270 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 398527007271 TM-ABC transporter signature motif; other site 398527007272 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 398527007273 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 398527007274 Walker A/P-loop; other site 398527007275 ATP binding site [chemical binding]; other site 398527007276 Q-loop/lid; other site 398527007277 ABC transporter signature motif; other site 398527007278 Walker B; other site 398527007279 D-loop; other site 398527007280 H-loop/switch region; other site 398527007281 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 398527007282 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 398527007283 Walker A/P-loop; other site 398527007284 ATP binding site [chemical binding]; other site 398527007285 Q-loop/lid; other site 398527007286 ABC transporter signature motif; other site 398527007287 Walker B; other site 398527007288 D-loop; other site 398527007289 H-loop/switch region; other site 398527007290 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 398527007291 active site 398527007292 substrate binding pocket [chemical binding]; other site 398527007293 homodimer interaction site [polypeptide binding]; other site 398527007294 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 398527007295 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 398527007296 inhibitor-cofactor binding pocket; inhibition site 398527007297 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527007298 catalytic residue [active] 398527007299 tetracycline repressor protein TetR; Provisional; Region: PRK13756 398527007300 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 398527007301 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 398527007302 indole acetimide hydrolase; Validated; Region: PRK07488 398527007303 Amidase; Region: Amidase; cl11426 398527007304 Tar ligand binding domain homologue; Region: TarH; pfam02203 398527007305 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 398527007306 dimerization interface [polypeptide binding]; other site 398527007307 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 398527007308 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 398527007309 dimer interface [polypeptide binding]; other site 398527007310 putative CheW interface [polypeptide binding]; other site 398527007311 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 398527007312 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 398527007313 active site 398527007314 catalytic tetrad [active] 398527007315 NmrA (a transcriptional regulator) and triphenylmethane reductase (TMR) like proteins, subgroup 1, atypical (a) SDRs; Region: NmrA_TMR_like_1_SDR_a; cd05231 398527007316 NmrA-like family; Region: NmrA; pfam05368 398527007317 putative NADP binding site [chemical binding]; other site 398527007318 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 398527007319 Beta-lactamase; Region: Beta-lactamase; pfam00144 398527007320 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527007321 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527007322 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 398527007323 putative effector binding pocket; other site 398527007324 dimerization interface [polypeptide binding]; other site 398527007325 Transcriptional regulators [Transcription]; Region: PurR; COG1609 398527007326 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 398527007327 DNA binding site [nucleotide binding] 398527007328 domain linker motif; other site 398527007329 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 398527007330 Winged helix-turn helix; Region: HTH_29; pfam13551 398527007331 Helix-turn-helix domain; Region: HTH_28; pfam13518 398527007332 Integrase core domain; Region: rve; pfam00665 398527007333 Integrase core domain; Region: rve_3; pfam13683 398527007334 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 398527007335 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 398527007336 trimer interface [polypeptide binding]; other site 398527007337 putative metal binding site [ion binding]; other site 398527007338 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 398527007339 Na binding site [ion binding]; other site 398527007340 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 398527007341 CoA-transferase family III; Region: CoA_transf_3; pfam02515 398527007342 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 398527007343 FAD binding domain; Region: FAD_binding_4; pfam01565 398527007344 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 398527007345 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194 398527007346 putative active site [active] 398527007347 metal binding site [ion binding]; metal-binding site 398527007348 NIPSNAP; Region: NIPSNAP; pfam07978 398527007349 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 398527007350 Integrase core domain; Region: rve; pfam00665 398527007351 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 398527007352 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527007353 Walker A motif; other site 398527007354 ATP binding site [chemical binding]; other site 398527007355 Walker B motif; other site 398527007356 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 398527007357 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 398527007358 Transposase; Region: HTH_Tnp_1; pfam01527 398527007359 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 398527007360 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 398527007361 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 398527007362 acyl-activating enzyme (AAE) consensus motif; other site 398527007363 AMP binding site [chemical binding]; other site 398527007364 active site 398527007365 CoA binding site [chemical binding]; other site 398527007366 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 398527007367 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 398527007368 putative NAD(P) binding site [chemical binding]; other site 398527007369 putative active site [active] 398527007370 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 398527007371 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 398527007372 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 398527007373 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 398527007374 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 398527007375 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 398527007376 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 398527007377 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 398527007378 acyl-activating enzyme (AAE) consensus motif; other site 398527007379 AMP binding site [chemical binding]; other site 398527007380 active site 398527007381 CoA binding site [chemical binding]; other site 398527007382 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 398527007383 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 398527007384 Walker A/P-loop; other site 398527007385 ATP binding site [chemical binding]; other site 398527007386 Q-loop/lid; other site 398527007387 ABC transporter signature motif; other site 398527007388 Walker B; other site 398527007389 D-loop; other site 398527007390 H-loop/switch region; other site 398527007391 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 398527007392 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 398527007393 Walker A/P-loop; other site 398527007394 ATP binding site [chemical binding]; other site 398527007395 Q-loop/lid; other site 398527007396 ABC transporter signature motif; other site 398527007397 Walker B; other site 398527007398 D-loop; other site 398527007399 H-loop/switch region; other site 398527007400 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 398527007401 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 398527007402 TM-ABC transporter signature motif; other site 398527007403 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 398527007404 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 398527007405 TM-ABC transporter signature motif; other site 398527007406 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 398527007407 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_3; cd06336 398527007408 putative ligand binding site [chemical binding]; other site 398527007409 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 398527007410 classical (c) SDRs; Region: SDR_c; cd05233 398527007411 NAD(P) binding site [chemical binding]; other site 398527007412 active site 398527007413 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 398527007414 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 398527007415 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 398527007416 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 398527007417 ligand binding site [chemical binding]; other site 398527007418 NAD binding site [chemical binding]; other site 398527007419 dimerization interface [polypeptide binding]; other site 398527007420 catalytic site [active] 398527007421 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 398527007422 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 398527007423 active site pocket [active] 398527007424 Cupin domain; Region: Cupin_2; cl17218 398527007425 Transcriptional regulators [Transcription]; Region: FadR; COG2186 398527007426 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527007427 DNA-binding site [nucleotide binding]; DNA binding site 398527007428 FCD domain; Region: FCD; pfam07729 398527007429 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527007430 D-galactonate transporter; Region: 2A0114; TIGR00893 398527007431 putative substrate translocation pore; other site 398527007432 AAA domain; Region: AAA_22; pfam13401 398527007433 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527007434 Walker A motif; other site 398527007435 ATP binding site [chemical binding]; other site 398527007436 Walker B motif; other site 398527007437 arginine finger; other site 398527007438 Winged helix-turn helix; Region: HTH_29; pfam13551 398527007439 Integrase core domain; Region: rve; pfam00665 398527007440 DEAD-like helicases superfamily; Region: DEXDc; smart00487 398527007441 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 398527007442 ATP-binding site [chemical binding]; other site 398527007443 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176 398527007444 PLD-like domain; Region: PLDc_2; pfam13091 398527007445 putative homodimer interface [polypeptide binding]; other site 398527007446 putative active site [active] 398527007447 catalytic site [active] 398527007448 NACHT domain; Region: NACHT; pfam05729 398527007449 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 398527007450 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 398527007451 Family description; Region: UvrD_C_2; pfam13538 398527007452 Part of AAA domain; Region: AAA_19; pfam13245 398527007453 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 398527007454 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 398527007455 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 398527007456 putative active site [active] 398527007457 putative metal-binding site [ion binding]; other site 398527007458 Domain of unknown function (DUF932); Region: DUF932; cl12129 398527007459 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 398527007460 active site 398527007461 catalytic residues [active] 398527007462 DNA binding site [nucleotide binding] 398527007463 Int/Topo IB signature motif; other site 398527007464 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 398527007465 active site 398527007466 catalytic residues [active] 398527007467 DNA binding site [nucleotide binding] 398527007468 Int/Topo IB signature motif; other site 398527007469 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 398527007470 Domain of unknown function (DUF932); Region: DUF932; cl12129 398527007471 ParB-like nuclease domain; Region: ParBc; pfam02195 398527007472 conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743 398527007473 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 398527007474 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 398527007475 non-specific DNA binding site [nucleotide binding]; other site 398527007476 salt bridge; other site 398527007477 sequence-specific DNA binding site [nucleotide binding]; other site 398527007478 type IV secretion system T-DNA border endonuclease VirD2; Provisional; Region: PRK13863 398527007479 Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707 398527007480 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 398527007481 active site 398527007482 metal binding site [ion binding]; metal-binding site 398527007483 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 398527007484 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 398527007485 Walker A motif; other site 398527007486 ATP binding site [chemical binding]; other site 398527007487 Walker B motif; other site 398527007488 conjugal transfer coupling protein TraG; Provisional; Region: PRK13876 398527007489 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 398527007490 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 398527007491 Walker A motif; other site 398527007492 hexamer interface [polypeptide binding]; other site 398527007493 ATP binding site [chemical binding]; other site 398527007494 Walker B motif; other site 398527007495 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 398527007496 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 398527007497 VirB7 interaction site; other site 398527007498 VirB8 protein; Region: VirB8; pfam04335 398527007499 P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791 398527007500 Type IV secretion system proteins; Region: T4SS; pfam07996 398527007501 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 398527007502 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 398527007503 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 398527007504 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 398527007505 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 398527007506 N-acetyl-D-glucosamine binding site [chemical binding]; other site 398527007507 catalytic residue [active] 398527007508 Condensation domain; Region: Condensation; pfam00668 398527007509 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 398527007510 ACT domain; Region: ACT_3; pfam10000 398527007511 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3602 398527007512 Family description; Region: ACT_7; pfam13840 398527007513 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 398527007514 Fatty acid desaturase; Region: FA_desaturase; pfam00487 398527007515 putative di-iron ligands [ion binding]; other site 398527007516 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 398527007517 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 398527007518 chromosome replication initiation inhibitor protein; Provisional; Region: PRK13348 398527007519 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527007520 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 398527007521 dimerization interface [polypeptide binding]; other site 398527007522 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 398527007523 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 398527007524 dimer interface [polypeptide binding]; other site 398527007525 putative CheW interface [polypeptide binding]; other site 398527007526 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 398527007527 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 398527007528 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 398527007529 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 398527007530 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 398527007531 Transposase; Region: HTH_Tnp_1; pfam01527 398527007532 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 398527007533 Predicted membrane protein [Function unknown]; Region: COG3817 398527007534 Protein of unknown function (DUF979); Region: DUF979; pfam06166 398527007535 Protein of unknown function (DUF969); Region: DUF969; pfam06149 398527007536 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 398527007537 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 398527007538 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527007539 homodimer interface [polypeptide binding]; other site 398527007540 catalytic residue [active] 398527007541 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 398527007542 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527007543 Walker A motif; other site 398527007544 ATP binding site [chemical binding]; other site 398527007545 Walker B motif; other site 398527007546 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 398527007547 Integrase core domain; Region: rve; pfam00665 398527007548 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 398527007549 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 398527007550 trimer interface [polypeptide binding]; other site 398527007551 eyelet of channel; other site 398527007552 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 398527007553 hydroxyglutarate oxidase; Provisional; Region: PRK11728 398527007554 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 398527007555 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 398527007556 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 398527007557 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 398527007558 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 398527007559 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 398527007560 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 398527007561 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 398527007562 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 398527007563 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 398527007564 putative DNA binding site [nucleotide binding]; other site 398527007565 putative Zn2+ binding site [ion binding]; other site 398527007566 AsnC family; Region: AsnC_trans_reg; pfam01037 398527007567 LrgA family; Region: LrgA; cl00608 398527007568 LrgB-like family; Region: LrgB; pfam04172 398527007569 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 398527007570 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527007571 dimer interface [polypeptide binding]; other site 398527007572 conserved gate region; other site 398527007573 putative PBP binding loops; other site 398527007574 ABC-ATPase subunit interface; other site 398527007575 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 398527007576 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527007577 dimer interface [polypeptide binding]; other site 398527007578 conserved gate region; other site 398527007579 putative PBP binding loops; other site 398527007580 ABC-ATPase subunit interface; other site 398527007581 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 398527007582 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 398527007583 Walker A/P-loop; other site 398527007584 ATP binding site [chemical binding]; other site 398527007585 Q-loop/lid; other site 398527007586 ABC transporter signature motif; other site 398527007587 Walker B; other site 398527007588 D-loop; other site 398527007589 H-loop/switch region; other site 398527007590 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 398527007591 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 398527007592 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 398527007593 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527007594 The C-terminal substrate binding domain of LysR, transcriptional regulator for lysine biosynthesis, contains the type 2 periplasmic binding fold; Region: PBP2_LysR; cd08456 398527007595 putative dimerization interface [polypeptide binding]; other site 398527007596 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 398527007597 active site 398527007598 Int/Topo IB signature motif; other site 398527007599 DNA binding site [nucleotide binding] 398527007600 integrase; Provisional; Region: PRK09692 398527007601 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 398527007602 active site 398527007603 Int/Topo IB signature motif; other site 398527007604 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 398527007605 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 398527007606 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 398527007607 active site 398527007608 Int/Topo IB signature motif; other site 398527007609 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 398527007610 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 398527007611 G1 box; other site 398527007612 putative GEF interaction site [polypeptide binding]; other site 398527007613 GTP/Mg2+ binding site [chemical binding]; other site 398527007614 Switch I region; other site 398527007615 G2 box; other site 398527007616 G3 box; other site 398527007617 Switch II region; other site 398527007618 G4 box; other site 398527007619 G5 box; other site 398527007620 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 398527007621 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 398527007622 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 398527007623 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 398527007624 selenocysteine synthase; Provisional; Region: PRK04311 398527007625 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 398527007626 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 398527007627 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 398527007628 catalytic residue [active] 398527007629 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 398527007630 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 398527007631 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 398527007632 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 398527007633 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 398527007634 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 398527007635 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 398527007636 molybdopterin cofactor binding site; other site 398527007637 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 398527007638 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 398527007639 molybdopterin cofactor binding site; other site 398527007640 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 398527007641 selenophosphate synthetase; Provisional; Region: PRK00943 398527007642 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 398527007643 dimerization interface [polypeptide binding]; other site 398527007644 putative ATP binding site [chemical binding]; other site 398527007645 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 398527007646 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 398527007647 active site residue [active] 398527007648 AAA domain; Region: AAA_17; pfam13207 398527007649 Predicted permease; Region: DUF318; cl17795 398527007650 dihydroxyacetone kinase; Provisional; Region: PRK14479 398527007651 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 398527007652 DAK2 domain; Region: Dak2; pfam02734 398527007653 Uncharacterized conserved protein [Function unknown]; Region: COG5476 398527007654 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 398527007655 MlrC C-terminus; Region: MlrC_C; pfam07171 398527007656 allantoate amidohydrolase; Reviewed; Region: PRK12893 398527007657 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 398527007658 active site 398527007659 metal binding site [ion binding]; metal-binding site 398527007660 dimer interface [polypeptide binding]; other site 398527007661 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 398527007662 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 398527007663 Walker A/P-loop; other site 398527007664 ATP binding site [chemical binding]; other site 398527007665 Q-loop/lid; other site 398527007666 ABC transporter signature motif; other site 398527007667 Walker B; other site 398527007668 D-loop; other site 398527007669 H-loop/switch region; other site 398527007670 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 398527007671 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 398527007672 Walker A/P-loop; other site 398527007673 ATP binding site [chemical binding]; other site 398527007674 Q-loop/lid; other site 398527007675 ABC transporter signature motif; other site 398527007676 Walker B; other site 398527007677 D-loop; other site 398527007678 H-loop/switch region; other site 398527007679 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 398527007680 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 398527007681 TM-ABC transporter signature motif; other site 398527007682 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 398527007683 TM-ABC transporter signature motif; other site 398527007684 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 398527007685 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 398527007686 putative ligand binding site [chemical binding]; other site 398527007687 Transcriptional regulators [Transcription]; Region: FadR; COG2186 398527007688 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527007689 DNA-binding site [nucleotide binding]; DNA binding site 398527007690 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 398527007691 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 398527007692 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 398527007693 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 398527007694 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 398527007695 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 398527007696 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 398527007697 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 398527007698 Transposase; Region: HTH_Tnp_1; pfam01527 398527007699 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 398527007700 AAA domain; Region: AAA_22; pfam13401 398527007701 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527007702 Walker A motif; other site 398527007703 ATP binding site [chemical binding]; other site 398527007704 Walker B motif; other site 398527007705 arginine finger; other site 398527007706 Winged helix-turn helix; Region: HTH_29; pfam13551 398527007707 Integrase core domain; Region: rve; pfam00665 398527007708 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 398527007709 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 398527007710 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 398527007711 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 398527007712 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 398527007713 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 398527007714 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 398527007715 DNA binding residues [nucleotide binding] 398527007716 PRC-barrel domain; Region: PRC; pfam05239 398527007717 Peptidase family M48; Region: Peptidase_M48; cl12018 398527007718 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 398527007719 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 398527007720 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 398527007721 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 398527007722 Predicted secreted protein [Function unknown]; Region: COG5445 398527007723 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 398527007724 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 398527007725 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 398527007726 MG2 domain; Region: A2M_N; pfam01835 398527007727 Alpha-2-macroglobulin family; Region: A2M; pfam00207 398527007728 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 398527007729 Protein of unknown function (DUF1175); Region: DUF1175; cl14898 398527007730 Uncharacterized protein conserved in bacteria (DUF2138); Region: DUF2138; pfam09909 398527007731 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 398527007732 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 398527007733 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527007734 homodimer interface [polypeptide binding]; other site 398527007735 catalytic residue [active] 398527007736 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 398527007737 hydroxyglutarate oxidase; Provisional; Region: PRK11728 398527007738 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 398527007739 aldehyde dehydrogenase family 7 member; Region: PLN02315 398527007740 tetrameric interface [polypeptide binding]; other site 398527007741 NAD binding site [chemical binding]; other site 398527007742 catalytic residues [active] 398527007743 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527007744 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527007745 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 398527007746 putative dimerization interface [polypeptide binding]; other site 398527007747 Response regulator receiver domain; Region: Response_reg; pfam00072 398527007748 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527007749 active site 398527007750 phosphorylation site [posttranslational modification] 398527007751 intermolecular recognition site; other site 398527007752 dimerization interface [polypeptide binding]; other site 398527007753 benzoate transport; Region: 2A0115; TIGR00895 398527007754 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527007755 putative substrate translocation pore; other site 398527007756 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527007757 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 398527007758 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 398527007759 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 398527007760 CoA-transferase family III; Region: CoA_transf_3; pfam02515 398527007761 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 398527007762 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 398527007763 active site 398527007764 Uncharacterized conserved protein [Function unknown]; Region: COG3777 398527007765 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 398527007766 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 398527007767 putative active site [active] 398527007768 putative catalytic site [active] 398527007769 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3826 398527007770 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 398527007771 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 398527007772 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 398527007773 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 398527007774 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 398527007775 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 398527007776 Probable cobalt transporter subunit (CbtA); Region: CbtA; pfam09490 398527007777 Phosphoglycerate mutase family; Region: PGAM; smart00855 398527007778 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 398527007779 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527007780 metabolite-proton symporter; Region: 2A0106; TIGR00883 398527007781 putative substrate translocation pore; other site 398527007782 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 398527007783 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 398527007784 trimer interface [polypeptide binding]; other site 398527007785 eyelet of channel; other site 398527007786 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 398527007787 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527007788 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 398527007789 putative dimerization interface [polypeptide binding]; other site 398527007790 putative substrate binding pocket [chemical binding]; other site 398527007791 RecA-superfamily ATPases implicated in signal transduction [Signal transduction mechanisms]; Region: RAD55; COG0467 398527007792 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 398527007793 Walker A motif; other site 398527007794 ATP binding site [chemical binding]; other site 398527007795 Walker B motif; other site 398527007796 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 398527007797 KaiC; Region: KaiC; pfam06745 398527007798 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 398527007799 Walker A motif; other site 398527007800 Walker A motif; other site 398527007801 ATP binding site [chemical binding]; other site 398527007802 ATP binding site [chemical binding]; other site 398527007803 Walker B motif; other site 398527007804 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 398527007805 dimer interface [polypeptide binding]; other site 398527007806 phosphorylation site [posttranslational modification] 398527007807 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527007808 ATP binding site [chemical binding]; other site 398527007809 G-X-G motif; other site 398527007810 Response regulator receiver domain; Region: Response_reg; pfam00072 398527007811 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527007812 active site 398527007813 phosphorylation site [posttranslational modification] 398527007814 intermolecular recognition site; other site 398527007815 dimerization interface [polypeptide binding]; other site 398527007816 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 398527007817 Fusaric acid resistance protein family; Region: FUSC; pfam04632 398527007818 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 398527007819 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 398527007820 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 398527007821 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 398527007822 HlyD family secretion protein; Region: HlyD_3; pfam13437 398527007823 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 398527007824 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 398527007825 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 398527007826 catalytic loop [active] 398527007827 iron binding site [ion binding]; other site 398527007828 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 398527007829 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 398527007830 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 398527007831 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 398527007832 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 398527007833 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 398527007834 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 398527007835 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 398527007836 TM-ABC transporter signature motif; other site 398527007837 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 398527007838 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 398527007839 Walker A/P-loop; other site 398527007840 ATP binding site [chemical binding]; other site 398527007841 Q-loop/lid; other site 398527007842 ABC transporter signature motif; other site 398527007843 Walker B; other site 398527007844 D-loop; other site 398527007845 H-loop/switch region; other site 398527007846 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 398527007847 D-xylose ABC transporter, substrate-binding protein; Region: xylF; TIGR02634 398527007848 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 398527007849 putative ligand binding site [chemical binding]; other site 398527007850 xylose isomerase; Provisional; Region: PRK05474 398527007851 xylose isomerase; Region: xylose_isom_A; TIGR02630 398527007852 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 398527007853 putative dimerization interface [polypeptide binding]; other site 398527007854 putative ligand binding site [chemical binding]; other site 398527007855 Transcriptional regulators [Transcription]; Region: PurR; COG1609 398527007856 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 398527007857 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527007858 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 398527007859 active site 398527007860 catalytic residues [active] 398527007861 Domain of unknown function (DUF4148); Region: DUF4148; pfam13663 398527007862 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 398527007863 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 398527007864 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 398527007865 Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile. CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902 398527007866 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 398527007867 TIGR02594 family protein; Region: TIGR02594 398527007868 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 398527007869 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 398527007870 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 398527007871 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 398527007872 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 398527007873 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 398527007874 dimer interface [polypeptide binding]; other site 398527007875 putative CheW interface [polypeptide binding]; other site 398527007876 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527007877 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527007878 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 398527007879 dimerization interface [polypeptide binding]; other site 398527007880 Sulfatase; Region: Sulfatase; cl17466 398527007881 choline-sulfatase; Region: chol_sulfatase; TIGR03417 398527007882 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527007883 metabolite-proton symporter; Region: 2A0106; TIGR00883 398527007884 putative substrate translocation pore; other site 398527007885 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 398527007886 FAD binding domain; Region: FAD_binding_4; pfam01565 398527007887 YCII-related domain; Region: YCII; cl00999 398527007888 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527007889 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527007890 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 398527007891 putative effector binding pocket; other site 398527007892 dimerization interface [polypeptide binding]; other site 398527007893 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 398527007894 TAP-like protein; Region: Abhydrolase_4; pfam08386 398527007895 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 398527007896 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 398527007897 active site 398527007898 non-prolyl cis peptide bond; other site 398527007899 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 398527007900 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 398527007901 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 398527007902 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 398527007903 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 398527007904 NAD(P) binding site [chemical binding]; other site 398527007905 active site 398527007906 short chain dehydrogenase; Provisional; Region: PRK06172 398527007907 classical (c) SDRs; Region: SDR_c; cd05233 398527007908 NAD(P) binding site [chemical binding]; other site 398527007909 active site 398527007910 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 398527007911 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 398527007912 active site 398527007913 DNA binding site [nucleotide binding] 398527007914 Int/Topo IB signature motif; other site 398527007915 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 398527007916 Putative transposase; Region: Y2_Tnp; pfam04986 398527007917 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 398527007918 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 398527007919 catalytic residues [active] 398527007920 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 398527007921 classical (c) SDRs; Region: SDR_c; cd05233 398527007922 NAD(P) binding site [chemical binding]; other site 398527007923 active site 398527007924 Predicted transcriptional regulators [Transcription]; Region: COG1733 398527007925 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 398527007926 glutathione S-transferase; Provisional; Region: PRK15113 398527007927 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 398527007928 C-terminal domain interface [polypeptide binding]; other site 398527007929 GSH binding site (G-site) [chemical binding]; other site 398527007930 dimer interface [polypeptide binding]; other site 398527007931 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 398527007932 putative substrate binding pocket (H-site) [chemical binding]; other site 398527007933 N-terminal domain interface [polypeptide binding]; other site 398527007934 Carboxylesterase family; Region: COesterase; pfam00135 398527007935 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 398527007936 substrate binding pocket [chemical binding]; other site 398527007937 catalytic triad [active] 398527007938 Uncharacterized conserved protein [Function unknown]; Region: COG5361 398527007939 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 398527007940 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 398527007941 Uncharacterized conserved protein [Function unknown]; Region: COG5361 398527007942 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 398527007943 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 398527007944 H-NS histone family; Region: Histone_HNS; pfam00816 398527007945 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 398527007946 Helix-turn-helix domain; Region: HTH_18; pfam12833 398527007947 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527007948 Predicted periplasmic protein (DUF2092); Region: DUF2092; pfam09865 398527007949 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 398527007950 Uncharacterized conserved protein [Function unknown]; Region: COG5361 398527007951 Response regulator receiver domain; Region: Response_reg; pfam00072 398527007952 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527007953 active site 398527007954 phosphorylation site [posttranslational modification] 398527007955 intermolecular recognition site; other site 398527007956 dimerization interface [polypeptide binding]; other site 398527007957 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 398527007958 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527007959 active site 398527007960 phosphorylation site [posttranslational modification] 398527007961 intermolecular recognition site; other site 398527007962 dimerization interface [polypeptide binding]; other site 398527007963 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 398527007964 DNA binding residues [nucleotide binding] 398527007965 dimerization interface [polypeptide binding]; other site 398527007966 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 398527007967 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 398527007968 dimer interface [polypeptide binding]; other site 398527007969 phosphorylation site [posttranslational modification] 398527007970 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527007971 ATP binding site [chemical binding]; other site 398527007972 Mg2+ binding site [ion binding]; other site 398527007973 G-X-G motif; other site 398527007974 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 398527007975 Sulfatase; Region: Sulfatase; pfam00884 398527007976 Peptidase C1-like family; Region: Peptidase_C1_2; cl17447 398527007977 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 398527007978 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 398527007979 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 398527007980 FeS/SAM binding site; other site 398527007981 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 398527007982 Domain of unknown function (DUF3331); Region: DUF3331; pfam11811 398527007983 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 398527007984 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 398527007985 DNA binding residues [nucleotide binding] 398527007986 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 398527007987 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 398527007988 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 398527007989 active site residue [active] 398527007990 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 398527007991 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 398527007992 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 398527007993 Mechanosensitive ion channel; Region: MS_channel; pfam00924 398527007994 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 398527007995 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 398527007996 ligand binding site [chemical binding]; other site 398527007997 flexible hinge region; other site 398527007998 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 398527007999 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 398527008000 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 398527008001 DNA binding site [nucleotide binding] 398527008002 Predicted ATPase [General function prediction only]; Region: COG3903 398527008003 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 398527008004 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527008005 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527008006 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 398527008007 putative effector binding pocket; other site 398527008008 dimerization interface [polypeptide binding]; other site 398527008009 short chain dehydrogenase; Provisional; Region: PRK06500 398527008010 classical (c) SDRs; Region: SDR_c; cd05233 398527008011 NAD(P) binding site [chemical binding]; other site 398527008012 active site 398527008013 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 398527008014 substrate binding site [chemical binding]; other site 398527008015 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 398527008016 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 398527008017 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 398527008018 Cupin; Region: Cupin_6; pfam12852 398527008019 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 398527008020 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527008021 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 398527008022 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 398527008023 Methyltransferase domain; Region: Methyltransf_31; pfam13847 398527008024 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 398527008025 S-adenosylmethionine binding site [chemical binding]; other site 398527008026 Methyltransferase domain; Region: Methyltransf_23; pfam13489 398527008027 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 398527008028 S-adenosylmethionine binding site [chemical binding]; other site 398527008029 Nucleotide-diphospho-sugar transferase; Region: Nucleotid_trans; pfam03407 398527008030 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 398527008031 S-adenosylmethionine binding site [chemical binding]; other site 398527008032 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 398527008033 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 398527008034 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 398527008035 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 398527008036 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 398527008037 Walker A/P-loop; other site 398527008038 ATP binding site [chemical binding]; other site 398527008039 Q-loop/lid; other site 398527008040 ABC transporter signature motif; other site 398527008041 Walker B; other site 398527008042 D-loop; other site 398527008043 H-loop/switch region; other site 398527008044 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 398527008045 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 398527008046 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 398527008047 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 398527008048 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 398527008049 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 398527008050 NAD(P) binding site [chemical binding]; other site 398527008051 active site 398527008052 amino acid transporter; Region: 2A0306; TIGR00909 398527008053 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 398527008054 hypothetical protein; Provisional; Region: PRK11469 398527008055 Domain of unknown function DUF; Region: DUF204; pfam02659 398527008056 Domain of unknown function DUF; Region: DUF204; pfam02659 398527008057 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 398527008058 CHASE domain; Region: CHASE; pfam03924 398527008059 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 398527008060 PAS domain; Region: PAS_9; pfam13426 398527008061 putative active site [active] 398527008062 heme pocket [chemical binding]; other site 398527008063 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 398527008064 PAS domain; Region: PAS_9; pfam13426 398527008065 putative active site [active] 398527008066 heme pocket [chemical binding]; other site 398527008067 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 398527008068 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 398527008069 metal binding site [ion binding]; metal-binding site 398527008070 active site 398527008071 I-site; other site 398527008072 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 398527008073 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 398527008074 substrate binding pocket [chemical binding]; other site 398527008075 membrane-bound complex binding site; other site 398527008076 hinge residues; other site 398527008077 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 398527008078 SnoaL-like domain; Region: SnoaL_3; pfam13474 398527008079 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 398527008080 putative heme binding pocket [chemical binding]; other site 398527008081 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 398527008082 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 398527008083 Predicted small integral membrane protein (DUF2160); Region: DUF2160; pfam09928 398527008084 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 398527008085 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527008086 dimer interface [polypeptide binding]; other site 398527008087 conserved gate region; other site 398527008088 putative PBP binding loops; other site 398527008089 ABC-ATPase subunit interface; other site 398527008090 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527008091 dimer interface [polypeptide binding]; other site 398527008092 conserved gate region; other site 398527008093 putative PBP binding loops; other site 398527008094 ABC-ATPase subunit interface; other site 398527008095 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 398527008096 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 398527008097 Walker A/P-loop; other site 398527008098 ATP binding site [chemical binding]; other site 398527008099 Q-loop/lid; other site 398527008100 ABC transporter signature motif; other site 398527008101 Walker B; other site 398527008102 D-loop; other site 398527008103 H-loop/switch region; other site 398527008104 TOBE domain; Region: TOBE_2; pfam08402 398527008105 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 398527008106 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 398527008107 Walker A/P-loop; other site 398527008108 ATP binding site [chemical binding]; other site 398527008109 Q-loop/lid; other site 398527008110 ABC transporter signature motif; other site 398527008111 Walker B; other site 398527008112 D-loop; other site 398527008113 H-loop/switch region; other site 398527008114 TOBE domain; Region: TOBE_2; pfam08402 398527008115 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 398527008116 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 398527008117 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 398527008118 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 398527008119 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 398527008120 C-terminal, alpha helical domain of Metaxin and related proteins; Region: GST_C_Metaxin; cd03193 398527008121 putative N-terminal domain interface [polypeptide binding]; other site 398527008122 Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847 398527008123 active site 398527008124 catalytic triad [active] 398527008125 oxyanion hole [active] 398527008126 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 398527008127 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 398527008128 aspartate racemase; Region: asp_race; TIGR00035 398527008129 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; pfam01177 398527008130 aspartate racemase; Region: asp_race; TIGR00035 398527008131 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 398527008132 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 398527008133 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527008134 putative substrate translocation pore; other site 398527008135 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 398527008136 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 398527008137 PYR/PP interface [polypeptide binding]; other site 398527008138 dimer interface [polypeptide binding]; other site 398527008139 TPP binding site [chemical binding]; other site 398527008140 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 398527008141 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 398527008142 TPP-binding site; other site 398527008143 dimer interface [polypeptide binding]; other site 398527008144 formyl-coenzyme A transferase; Provisional; Region: PRK05398 398527008145 CoA-transferase family III; Region: CoA_transf_3; pfam02515 398527008146 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 398527008147 PAS fold; Region: PAS_3; pfam08447 398527008148 putative active site [active] 398527008149 heme pocket [chemical binding]; other site 398527008150 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527008151 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527008152 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 398527008153 putative effector binding pocket; other site 398527008154 putative dimerization interface [polypeptide binding]; other site 398527008155 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 398527008156 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 398527008157 FMN binding site [chemical binding]; other site 398527008158 substrate binding site [chemical binding]; other site 398527008159 putative catalytic residue [active] 398527008160 drug efflux system protein MdtG; Provisional; Region: PRK09874 398527008161 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527008162 putative substrate translocation pore; other site 398527008163 PBP superfamily domain; Region: PBP_like_2; cl17296 398527008164 CHAD domain; Region: CHAD; pfam05235 398527008165 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 398527008166 Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834 398527008167 Cl binding site [ion binding]; other site 398527008168 oligomer interface [polypeptide binding]; other site 398527008169 PBP superfamily domain; Region: PBP_like_2; cl17296 398527008170 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 398527008171 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 398527008172 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 398527008173 non-specific DNA binding site [nucleotide binding]; other site 398527008174 salt bridge; other site 398527008175 sequence-specific DNA binding site [nucleotide binding]; other site 398527008176 Cupin domain; Region: Cupin_2; pfam07883 398527008177 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 398527008178 FAD binding domain; Region: FAD_binding_4; pfam01565 398527008179 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 398527008180 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 398527008181 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 398527008182 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527008183 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 398527008184 dimerization interface [polypeptide binding]; other site 398527008185 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 398527008186 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 398527008187 dimer interface [polypeptide binding]; other site 398527008188 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 398527008189 active site 398527008190 Fe binding site [ion binding]; other site 398527008191 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 398527008192 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527008193 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 398527008194 putative dimerization interface [polypeptide binding]; other site 398527008195 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 398527008196 heterodimer interface [polypeptide binding]; other site 398527008197 multimer interface [polypeptide binding]; other site 398527008198 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 398527008199 active site 398527008200 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 398527008201 heterodimer interface [polypeptide binding]; other site 398527008202 active site 398527008203 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 398527008204 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 398527008205 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 398527008206 LysE type translocator; Region: LysE; cl00565 398527008207 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 398527008208 DNA-binding site [nucleotide binding]; DNA binding site 398527008209 RNA-binding motif; other site 398527008210 acyl-CoA synthetase; Validated; Region: PRK08162 398527008211 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 398527008212 acyl-activating enzyme (AAE) consensus motif; other site 398527008213 putative active site [active] 398527008214 AMP binding site [chemical binding]; other site 398527008215 putative CoA binding site [chemical binding]; other site 398527008216 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 398527008217 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 398527008218 ligand binding site [chemical binding]; other site 398527008219 flexible hinge region; other site 398527008220 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 398527008221 Cache domain; Region: Cache_2; pfam08269 398527008222 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 398527008223 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 398527008224 dimer interface [polypeptide binding]; other site 398527008225 putative CheW interface [polypeptide binding]; other site 398527008226 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 398527008227 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 398527008228 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 398527008229 trimer interface [polypeptide binding]; other site 398527008230 eyelet of channel; other site 398527008231 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 398527008232 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 398527008233 eyelet of channel; other site 398527008234 trimer interface [polypeptide binding]; other site 398527008235 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 398527008236 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 398527008237 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 398527008238 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 398527008239 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 398527008240 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 398527008241 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 398527008242 DNA binding residues [nucleotide binding] 398527008243 DNA primase; Validated; Region: dnaG; PRK05667 398527008244 CHC2 zinc finger; Region: zf-CHC2; pfam01807 398527008245 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 398527008246 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 398527008247 active site 398527008248 metal binding site [ion binding]; metal-binding site 398527008249 interdomain interaction site; other site 398527008250 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 398527008251 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879 398527008252 Yqey-like protein; Region: YqeY; pfam09424 398527008253 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 398527008254 HI0933-like protein; Region: HI0933_like; pfam03486 398527008255 UGMP family protein; Validated; Region: PRK09604 398527008256 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 398527008257 putative GTP cyclohydrolase; Provisional; Region: PRK13674 398527008258 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 398527008259 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 398527008260 TPP-binding site; other site 398527008261 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 398527008262 PYR/PP interface [polypeptide binding]; other site 398527008263 dimer interface [polypeptide binding]; other site 398527008264 TPP binding site [chemical binding]; other site 398527008265 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 398527008266 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 398527008267 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 398527008268 substrate binding pocket [chemical binding]; other site 398527008269 chain length determination region; other site 398527008270 substrate-Mg2+ binding site; other site 398527008271 catalytic residues [active] 398527008272 aspartate-rich region 1; other site 398527008273 active site lid residues [active] 398527008274 aspartate-rich region 2; other site 398527008275 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 398527008276 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 398527008277 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 398527008278 [2Fe-2S] cluster binding site [ion binding]; other site 398527008279 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 398527008280 alpha subunit interface [polypeptide binding]; other site 398527008281 active site 398527008282 substrate binding site [chemical binding]; other site 398527008283 Fe binding site [ion binding]; other site 398527008284 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 398527008285 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 398527008286 active site residue [active] 398527008287 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 398527008288 active site residue [active] 398527008289 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 398527008290 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 398527008291 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 398527008292 DNA polymerase I; Provisional; Region: PRK05755 398527008293 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 398527008294 active site 398527008295 metal binding site 1 [ion binding]; metal-binding site 398527008296 putative 5' ssDNA interaction site; other site 398527008297 metal binding site 3; metal-binding site 398527008298 metal binding site 2 [ion binding]; metal-binding site 398527008299 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 398527008300 putative DNA binding site [nucleotide binding]; other site 398527008301 putative metal binding site [ion binding]; other site 398527008302 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 398527008303 active site 398527008304 catalytic site [active] 398527008305 substrate binding site [chemical binding]; other site 398527008306 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 398527008307 active site 398527008308 DNA binding site [nucleotide binding] 398527008309 catalytic site [active] 398527008310 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 398527008311 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 398527008312 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527008313 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 398527008314 dimerization interface [polypeptide binding]; other site 398527008315 substrate binding pocket [chemical binding]; other site 398527008316 Chromate transporter; Region: Chromate_transp; pfam02417 398527008317 Chromate transporter; Region: Chromate_transp; pfam02417 398527008318 AMP nucleosidase; Provisional; Region: PRK08292 398527008319 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 398527008320 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 398527008321 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 398527008322 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 398527008323 putative active site [active] 398527008324 putative substrate binding site [chemical binding]; other site 398527008325 ATP binding site [chemical binding]; other site 398527008326 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 398527008327 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 398527008328 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 398527008329 putative DNA binding site [nucleotide binding]; other site 398527008330 putative Zn2+ binding site [ion binding]; other site 398527008331 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 398527008332 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 398527008333 DNA photolyase; Region: DNA_photolyase; pfam00875 398527008334 TspO/MBR family; Region: TspO_MBR; pfam03073 398527008335 Protein of unknown function (DUF3563); Region: DUF3563; pfam12086 398527008336 Esterase PHB depolymerase; Region: Esterase_phd; pfam10503 398527008337 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 398527008338 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 398527008339 active site 398527008340 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 398527008341 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 398527008342 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527008343 dimer interface [polypeptide binding]; other site 398527008344 conserved gate region; other site 398527008345 putative PBP binding loops; other site 398527008346 ABC-ATPase subunit interface; other site 398527008347 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 398527008348 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 398527008349 Walker A/P-loop; other site 398527008350 ATP binding site [chemical binding]; other site 398527008351 Q-loop/lid; other site 398527008352 ABC transporter signature motif; other site 398527008353 Walker B; other site 398527008354 D-loop; other site 398527008355 H-loop/switch region; other site 398527008356 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 398527008357 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 398527008358 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 398527008359 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 398527008360 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 398527008361 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 398527008362 NAD(P) binding site [chemical binding]; other site 398527008363 active site 398527008364 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 398527008365 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 398527008366 trimer interface [polypeptide binding]; other site 398527008367 eyelet of channel; other site 398527008368 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 398527008369 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 398527008370 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 398527008371 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527008372 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 398527008373 dimerization interface [polypeptide binding]; other site 398527008374 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 398527008375 RES domain; Region: RES; smart00953 398527008376 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 398527008377 active site 398527008378 metal binding site [ion binding]; metal-binding site 398527008379 Cytochrome c; Region: Cytochrom_C; pfam00034 398527008380 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 398527008381 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 398527008382 Cytochrome c; Region: Cytochrom_C; pfam00034 398527008383 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 398527008384 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 398527008385 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 398527008386 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 398527008387 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 398527008388 active site 398527008389 catalytic site [active] 398527008390 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 398527008391 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 398527008392 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 398527008393 active site 398527008394 homodimer interface [polypeptide binding]; other site 398527008395 catalytic site [active] 398527008396 acceptor binding site [chemical binding]; other site 398527008397 trehalose synthase; Region: treS_nterm; TIGR02456 398527008398 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 398527008399 active site 398527008400 catalytic site [active] 398527008401 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 398527008402 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 398527008403 glycogen branching enzyme; Provisional; Region: PRK05402 398527008404 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 398527008405 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 398527008406 active site 398527008407 catalytic site [active] 398527008408 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 398527008409 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 398527008410 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 398527008411 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 398527008412 active site 398527008413 catalytic site [active] 398527008414 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 398527008415 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 398527008416 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 398527008417 catalytic site [active] 398527008418 active site 398527008419 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 398527008420 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 398527008421 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 398527008422 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 398527008423 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 398527008424 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 398527008425 active site 398527008426 catalytic site [active] 398527008427 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 398527008428 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 398527008429 Domain of unknown function DUF21; Region: DUF21; pfam01595 398527008430 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 398527008431 Transporter associated domain; Region: CorC_HlyC; smart01091 398527008432 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 398527008433 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 398527008434 dimer interface [polypeptide binding]; other site 398527008435 phosphorylation site [posttranslational modification] 398527008436 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 398527008437 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 398527008438 Cupin domain; Region: Cupin_2; cl17218 398527008439 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527008440 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 398527008441 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527008442 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 398527008443 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 398527008444 homodimer interface [polypeptide binding]; other site 398527008445 substrate-cofactor binding pocket; other site 398527008446 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527008447 catalytic residue [active] 398527008448 amidophosphoribosyltransferase; Provisional; Region: PRK09246 398527008449 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 398527008450 active site 398527008451 tetramer interface [polypeptide binding]; other site 398527008452 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 398527008453 active site 398527008454 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 398527008455 Colicin V production protein; Region: Colicin_V; pfam02674 398527008456 Sporulation related domain; Region: SPOR; pfam05036 398527008457 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 398527008458 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 398527008459 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 398527008460 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 398527008461 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 398527008462 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 398527008463 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 398527008464 substrate binding site [chemical binding]; other site 398527008465 active site 398527008466 catalytic residues [active] 398527008467 heterodimer interface [polypeptide binding]; other site 398527008468 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 398527008469 DNA methylase; Region: N6_N4_Mtase; pfam01555 398527008470 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 398527008471 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 398527008472 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527008473 catalytic residue [active] 398527008474 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 398527008475 active site 398527008476 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 398527008477 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 398527008478 dimerization interface 3.5A [polypeptide binding]; other site 398527008479 active site 398527008480 FimV C-terminal domain; Region: FimV_Cterm; TIGR03504 398527008481 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 398527008482 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 398527008483 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 398527008484 tartrate dehydrogenase; Region: TTC; TIGR02089 398527008485 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 398527008486 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 398527008487 substrate binding site [chemical binding]; other site 398527008488 Predicted small secreted protein [Function unknown]; Region: COG5510 398527008489 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 398527008490 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 398527008491 substrate binding site [chemical binding]; other site 398527008492 ligand binding site [chemical binding]; other site 398527008493 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 398527008494 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 398527008495 dimer interface [polypeptide binding]; other site 398527008496 active site 398527008497 citrylCoA binding site [chemical binding]; other site 398527008498 NADH binding [chemical binding]; other site 398527008499 cationic pore residues; other site 398527008500 oxalacetate/citrate binding site [chemical binding]; other site 398527008501 coenzyme A binding site [chemical binding]; other site 398527008502 catalytic triad [active] 398527008503 Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110 398527008504 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 398527008505 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 398527008506 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07057 398527008507 L-aspartate oxidase; Provisional; Region: PRK06175 398527008508 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 398527008509 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 398527008510 SdhC subunit interface [polypeptide binding]; other site 398527008511 proximal heme binding site [chemical binding]; other site 398527008512 cardiolipin binding site; other site 398527008513 Iron-sulfur protein interface; other site 398527008514 proximal quinone binding site [chemical binding]; other site 398527008515 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 398527008516 Iron-sulfur protein interface; other site 398527008517 proximal quinone binding site [chemical binding]; other site 398527008518 SdhD (CybS) interface [polypeptide binding]; other site 398527008519 proximal heme binding site [chemical binding]; other site 398527008520 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 398527008521 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527008522 DNA-binding site [nucleotide binding]; DNA binding site 398527008523 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 398527008524 malate dehydrogenase; Provisional; Region: PRK05442 398527008525 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 398527008526 NAD(P) binding site [chemical binding]; other site 398527008527 dimer interface [polypeptide binding]; other site 398527008528 malate binding site [chemical binding]; other site 398527008529 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 398527008530 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 398527008531 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 398527008532 dimer interface [polypeptide binding]; other site 398527008533 active site 398527008534 citrylCoA binding site [chemical binding]; other site 398527008535 oxalacetate/citrate binding site [chemical binding]; other site 398527008536 coenzyme A binding site [chemical binding]; other site 398527008537 catalytic triad [active] 398527008538 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 398527008539 2-methylcitrate dehydratase; Region: prpD; TIGR02330 398527008540 aconitate hydratase; Provisional; Region: acnA; PRK12881 398527008541 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 398527008542 substrate binding site [chemical binding]; other site 398527008543 ligand binding site [chemical binding]; other site 398527008544 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 398527008545 substrate binding site [chemical binding]; other site 398527008546 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 398527008547 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 398527008548 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 398527008549 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527008550 active site 398527008551 phosphorylation site [posttranslational modification] 398527008552 intermolecular recognition site; other site 398527008553 dimerization interface [polypeptide binding]; other site 398527008554 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 398527008555 DNA binding residues [nucleotide binding] 398527008556 dimerization interface [polypeptide binding]; other site 398527008557 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 398527008558 ligand binding site [chemical binding]; other site 398527008559 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 398527008560 trimer interface [polypeptide binding]; other site 398527008561 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 398527008562 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 398527008563 trimer interface [polypeptide binding]; other site 398527008564 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 398527008565 trimer interface [polypeptide binding]; other site 398527008566 YadA-like C-terminal region; Region: YadA; pfam03895 398527008567 acyl-CoA synthetase; Validated; Region: PRK08162 398527008568 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 398527008569 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 398527008570 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 398527008571 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 398527008572 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 398527008573 phosphopeptide binding site; other site 398527008574 Type II/IV secretion system protein; Region: T2SE; pfam00437 398527008575 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 398527008576 ATP binding site [chemical binding]; other site 398527008577 Walker A motif; other site 398527008578 hexamer interface [polypeptide binding]; other site 398527008579 Walker B motif; other site 398527008580 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 398527008581 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 398527008582 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 398527008583 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 398527008584 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 398527008585 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 398527008586 TadE-like protein; Region: TadE; pfam07811 398527008587 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 398527008588 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 398527008589 N-acetyl-D-glucosamine binding site [chemical binding]; other site 398527008590 catalytic residue [active] 398527008591 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 398527008592 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 398527008593 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527008594 active site 398527008595 phosphorylation site [posttranslational modification] 398527008596 intermolecular recognition site; other site 398527008597 dimerization interface [polypeptide binding]; other site 398527008598 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 398527008599 DNA binding residues [nucleotide binding] 398527008600 dimerization interface [polypeptide binding]; other site 398527008601 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 398527008602 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 398527008603 ligand binding site [chemical binding]; other site 398527008604 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 398527008605 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527008606 dimer interface [polypeptide binding]; other site 398527008607 conserved gate region; other site 398527008608 putative PBP binding loops; other site 398527008609 ABC-ATPase subunit interface; other site 398527008610 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527008611 dimer interface [polypeptide binding]; other site 398527008612 conserved gate region; other site 398527008613 putative PBP binding loops; other site 398527008614 ABC-ATPase subunit interface; other site 398527008615 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 398527008616 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 398527008617 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 398527008618 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 398527008619 Walker A/P-loop; other site 398527008620 ATP binding site [chemical binding]; other site 398527008621 Q-loop/lid; other site 398527008622 ABC transporter signature motif; other site 398527008623 Walker B; other site 398527008624 D-loop; other site 398527008625 H-loop/switch region; other site 398527008626 TOBE domain; Region: TOBE_2; pfam08402 398527008627 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 398527008628 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527008629 DNA-binding site [nucleotide binding]; DNA binding site 398527008630 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 398527008631 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527008632 homodimer interface [polypeptide binding]; other site 398527008633 catalytic residue [active] 398527008634 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 398527008635 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 398527008636 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 398527008637 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 398527008638 Uncharacterized conserved protein [Function unknown]; Region: COG5361 398527008639 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 398527008640 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 398527008641 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 398527008642 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 398527008643 metal-binding site [ion binding] 398527008644 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 398527008645 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 398527008646 metal-binding site [ion binding] 398527008647 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 398527008648 Cache domain; Region: Cache_1; pfam02743 398527008649 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 398527008650 dimerization interface [polypeptide binding]; other site 398527008651 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 398527008652 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 398527008653 dimer interface [polypeptide binding]; other site 398527008654 putative CheW interface [polypeptide binding]; other site 398527008655 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 398527008656 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 398527008657 putative C-terminal domain interface [polypeptide binding]; other site 398527008658 putative GSH binding site (G-site) [chemical binding]; other site 398527008659 putative dimer interface [polypeptide binding]; other site 398527008660 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 398527008661 putative N-terminal domain interface [polypeptide binding]; other site 398527008662 putative dimer interface [polypeptide binding]; other site 398527008663 putative substrate binding pocket (H-site) [chemical binding]; other site 398527008664 polyhydroxyalkanoate depolymerase, intracellular; Region: PHB_depoly_PhaZ; TIGR01849 398527008665 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 398527008666 Cupin domain; Region: Cupin_2; cl17218 398527008667 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 398527008668 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 398527008669 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 398527008670 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 398527008671 MgtC family; Region: MgtC; pfam02308 398527008672 dimerization interface [polypeptide binding]; other site 398527008673 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 398527008674 putative active cleft [active] 398527008675 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 398527008676 active site 398527008677 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 398527008678 DNA-binding site [nucleotide binding]; DNA binding site 398527008679 RNA-binding motif; other site 398527008680 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 398527008681 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 398527008682 dimer interface [polypeptide binding]; other site 398527008683 ligand binding site [chemical binding]; other site 398527008684 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 398527008685 dimerization interface [polypeptide binding]; other site 398527008686 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 398527008687 dimer interface [polypeptide binding]; other site 398527008688 putative CheW interface [polypeptide binding]; other site 398527008689 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 398527008690 CoenzymeA binding site [chemical binding]; other site 398527008691 subunit interaction site [polypeptide binding]; other site 398527008692 PHB binding site; other site 398527008693 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 398527008694 dimerization interface [polypeptide binding]; other site 398527008695 putative DNA binding site [nucleotide binding]; other site 398527008696 putative Zn2+ binding site [ion binding]; other site 398527008697 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 398527008698 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 398527008699 catalytic residue [active] 398527008700 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 398527008701 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 398527008702 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 398527008703 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 398527008704 NAD binding site [chemical binding]; other site 398527008705 homotetramer interface [polypeptide binding]; other site 398527008706 homodimer interface [polypeptide binding]; other site 398527008707 active site 398527008708 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 398527008709 Amidohydrolase; Region: Amidohydro_2; pfam04909 398527008710 active site 398527008711 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 398527008712 active site 398527008713 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 398527008714 catalytic tetrad [active] 398527008715 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 398527008716 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 398527008717 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 398527008718 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 398527008719 TM-ABC transporter signature motif; other site 398527008720 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 398527008721 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 398527008722 Walker A/P-loop; other site 398527008723 ATP binding site [chemical binding]; other site 398527008724 Q-loop/lid; other site 398527008725 ABC transporter signature motif; other site 398527008726 Walker B; other site 398527008727 D-loop; other site 398527008728 H-loop/switch region; other site 398527008729 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 398527008730 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 398527008731 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 398527008732 ligand binding site [chemical binding]; other site 398527008733 Transcriptional regulator [Transcription]; Region: IclR; COG1414 398527008734 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 398527008735 Bacterial transcriptional regulator; Region: IclR; pfam01614 398527008736 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 398527008737 CoA binding domain; Region: CoA_binding_2; pfam13380 398527008738 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 398527008739 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 398527008740 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 398527008741 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 398527008742 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527008743 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 398527008744 dimerization interface [polypeptide binding]; other site 398527008745 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 398527008746 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 398527008747 G1 box; other site 398527008748 putative GEF interaction site [polypeptide binding]; other site 398527008749 GTP/Mg2+ binding site [chemical binding]; other site 398527008750 Switch I region; other site 398527008751 G2 box; other site 398527008752 G3 box; other site 398527008753 Switch II region; other site 398527008754 G4 box; other site 398527008755 G5 box; other site 398527008756 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 398527008757 Fimbrial protein; Region: Fimbrial; pfam00419 398527008758 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 398527008759 PapC N-terminal domain; Region: PapC_N; pfam13954 398527008760 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 398527008761 PapC C-terminal domain; Region: PapC_C; pfam13953 398527008762 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 398527008763 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 398527008764 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 398527008765 benzoate transport; Region: 2A0115; TIGR00895 398527008766 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527008767 putative substrate translocation pore; other site 398527008768 succinic semialdehyde dehydrogenase; Region: PLN02278 398527008769 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 398527008770 tetramerization interface [polypeptide binding]; other site 398527008771 NAD(P) binding site [chemical binding]; other site 398527008772 catalytic residues [active] 398527008773 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 398527008774 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 398527008775 active site 398527008776 catalytic tetrad [active] 398527008777 Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714 398527008778 H-NS histone family; Region: Histone_HNS; pfam00816 398527008779 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 398527008780 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 398527008781 Beta-lactamase; Region: Beta-lactamase; pfam00144 398527008782 PAS fold; Region: PAS_4; pfam08448 398527008783 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 398527008784 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 398527008785 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527008786 Walker A motif; other site 398527008787 ATP binding site [chemical binding]; other site 398527008788 Walker B motif; other site 398527008789 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 398527008790 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 398527008791 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 398527008792 homotrimer interaction site [polypeptide binding]; other site 398527008793 putative active site [active] 398527008794 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 398527008795 dimer interface [polypeptide binding]; other site 398527008796 phosphorylation site [posttranslational modification] 398527008797 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527008798 ATP binding site [chemical binding]; other site 398527008799 Mg2+ binding site [ion binding]; other site 398527008800 G-X-G motif; other site 398527008801 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527008802 active site 398527008803 phosphorylation site [posttranslational modification] 398527008804 intermolecular recognition site; other site 398527008805 dimerization interface [polypeptide binding]; other site 398527008806 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 398527008807 PAS domain; Region: PAS_9; pfam13426 398527008808 putative active site [active] 398527008809 heme pocket [chemical binding]; other site 398527008810 HAMP domain; Region: HAMP; pfam00672 398527008811 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 398527008812 dimer interface [polypeptide binding]; other site 398527008813 putative CheW interface [polypeptide binding]; other site 398527008814 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 398527008815 DinB superfamily; Region: DinB_2; pfam12867 398527008816 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 398527008817 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 398527008818 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 398527008819 active site residue [active] 398527008820 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 398527008821 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 398527008822 ligand binding site [chemical binding]; other site 398527008823 flexible hinge region; other site 398527008824 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 398527008825 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 398527008826 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 398527008827 Uncharacterized conserved protein [Function unknown]; Region: COG3391 398527008828 EamA-like transporter family; Region: EamA; pfam00892 398527008829 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 398527008830 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 398527008831 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527008832 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 398527008833 FAD binding domain; Region: FAD_binding_4; pfam01565 398527008834 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 398527008835 Cysteine-rich domain; Region: CCG; pfam02754 398527008836 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 398527008837 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527008838 D-galactonate transporter; Region: 2A0114; TIGR00893 398527008839 putative substrate translocation pore; other site 398527008840 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 398527008841 homodimer interface [polypeptide binding]; other site 398527008842 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527008843 catalytic residue [active] 398527008844 Transcriptional regulators [Transcription]; Region: GntR; COG1802 398527008845 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527008846 DNA-binding site [nucleotide binding]; DNA binding site 398527008847 FCD domain; Region: FCD; pfam07729 398527008848 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 398527008849 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527008850 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 398527008851 dimerization interface [polypeptide binding]; other site 398527008852 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 398527008853 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 398527008854 Walker A/P-loop; other site 398527008855 ATP binding site [chemical binding]; other site 398527008856 Q-loop/lid; other site 398527008857 ABC transporter signature motif; other site 398527008858 Walker B; other site 398527008859 D-loop; other site 398527008860 H-loop/switch region; other site 398527008861 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527008862 dimer interface [polypeptide binding]; other site 398527008863 conserved gate region; other site 398527008864 putative PBP binding loops; other site 398527008865 ABC-ATPase subunit interface; other site 398527008866 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 398527008867 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527008868 dimer interface [polypeptide binding]; other site 398527008869 conserved gate region; other site 398527008870 putative PBP binding loops; other site 398527008871 ABC-ATPase subunit interface; other site 398527008872 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 398527008873 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 398527008874 substrate binding pocket [chemical binding]; other site 398527008875 membrane-bound complex binding site; other site 398527008876 hinge residues; other site 398527008877 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 398527008878 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527008879 The C-terminal substrate-domain of LysR-type transcriptional regulators involved in the catabolism of opines and that of related regulators, contains the type 2 periplasmic binding fold; Region: PBP2_LysR_opines_like; cd08415 398527008880 putative dimerization interface [polypeptide binding]; other site 398527008881 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 398527008882 metal binding site [ion binding]; metal-binding site 398527008883 active site 398527008884 I-site; other site 398527008885 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 398527008886 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 398527008887 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 398527008888 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527008889 D-galactonate transporter; Region: 2A0114; TIGR00893 398527008890 putative substrate translocation pore; other site 398527008891 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 398527008892 active site 398527008893 catalytic residues [active] 398527008894 metal binding site [ion binding]; metal-binding site 398527008895 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 398527008896 CoA-transferase family III; Region: CoA_transf_3; pfam02515 398527008897 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527008898 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527008899 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 398527008900 putative dimerization interface [polypeptide binding]; other site 398527008901 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 398527008902 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 398527008903 conserved cys residue [active] 398527008904 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527008905 short chain dehydrogenase; Provisional; Region: PRK07023 398527008906 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 398527008907 NAD(P) binding site [chemical binding]; other site 398527008908 active site 398527008909 osmolarity response regulator; Provisional; Region: ompR; PRK09468 398527008910 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527008911 active site 398527008912 phosphorylation site [posttranslational modification] 398527008913 intermolecular recognition site; other site 398527008914 dimerization interface [polypeptide binding]; other site 398527008915 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 398527008916 DNA binding site [nucleotide binding] 398527008917 Response regulator receiver domain; Region: Response_reg; pfam00072 398527008918 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527008919 active site 398527008920 phosphorylation site [posttranslational modification] 398527008921 intermolecular recognition site; other site 398527008922 dimerization interface [polypeptide binding]; other site 398527008923 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 398527008924 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 398527008925 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 398527008926 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 398527008927 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 398527008928 dimerization interface [polypeptide binding]; other site 398527008929 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 398527008930 putative binding surface; other site 398527008931 active site 398527008932 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527008933 ATP binding site [chemical binding]; other site 398527008934 Mg2+ binding site [ion binding]; other site 398527008935 G-X-G motif; other site 398527008936 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 398527008937 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 398527008938 putative active site [active] 398527008939 catalytic site [active] 398527008940 Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173 398527008941 putative active site [active] 398527008942 catalytic site [active] 398527008943 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 398527008944 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 398527008945 active site 398527008946 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 398527008947 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 398527008948 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 398527008949 Protein export membrane protein; Region: SecD_SecF; cl14618 398527008950 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 398527008951 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 398527008952 HlyD family secretion protein; Region: HlyD_3; pfam13437 398527008953 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 398527008954 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527008955 active site 398527008956 phosphorylation site [posttranslational modification] 398527008957 intermolecular recognition site; other site 398527008958 dimerization interface [polypeptide binding]; other site 398527008959 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 398527008960 DNA binding site [nucleotide binding] 398527008961 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 398527008962 dimerization interface [polypeptide binding]; other site 398527008963 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 398527008964 dimer interface [polypeptide binding]; other site 398527008965 phosphorylation site [posttranslational modification] 398527008966 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527008967 ATP binding site [chemical binding]; other site 398527008968 Mg2+ binding site [ion binding]; other site 398527008969 G-X-G motif; other site 398527008970 Superinfection immunity protein; Region: Imm_superinfect; pfam14373 398527008971 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 398527008972 SnoaL-like domain; Region: SnoaL_2; pfam12680 398527008973 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 398527008974 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 398527008975 YceI-like domain; Region: YceI; smart00867 398527008976 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 398527008977 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 398527008978 NAD(P) binding site [chemical binding]; other site 398527008979 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 398527008980 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 398527008981 substrate-cofactor binding pocket; other site 398527008982 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527008983 catalytic residue [active] 398527008984 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 398527008985 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 398527008986 non-specific DNA binding site [nucleotide binding]; other site 398527008987 salt bridge; other site 398527008988 sequence-specific DNA binding site [nucleotide binding]; other site 398527008989 Cupin domain; Region: Cupin_2; pfam07883 398527008990 Protein of unknown function (DUF2471); Region: DUF2471; pfam10616 398527008991 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 398527008992 active site 398527008993 catalytic residues [active] 398527008994 Int/Topo IB signature motif; other site 398527008995 DNA binding site [nucleotide binding] 398527008996 Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740 398527008997 Initiator Replication protein; Region: Rep_3; pfam01051 398527008998 ParB-like nuclease domain; Region: ParB; smart00470 398527008999 ParA-like protein; Provisional; Region: PHA02518 398527009000 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 398527009001 P-loop; other site 398527009002 Magnesium ion binding site [ion binding]; other site 398527009003 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 398527009004 ArsC family; Region: ArsC; pfam03960 398527009005 catalytic residues [active] 398527009006 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 398527009007 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 398527009008 substrate binding pocket [chemical binding]; other site 398527009009 membrane-bound complex binding site; other site 398527009010 fructuronate transporter; Provisional; Region: PRK10034; cl15264 398527009011 GntP family permease; Region: GntP_permease; pfam02447 398527009012 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 398527009013 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 398527009014 Putative zinc-finger; Region: zf-HC2; pfam13490 398527009015 RNA polymerase sigma factor; Provisional; Region: PRK12545 398527009016 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 398527009017 DNA binding residues [nucleotide binding] 398527009018 Predicted flavoprotein [General function prediction only]; Region: COG0431 398527009019 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 398527009020 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 398527009021 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527009022 ATP binding site [chemical binding]; other site 398527009023 Mg2+ binding site [ion binding]; other site 398527009024 G-X-G motif; other site 398527009025 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 398527009026 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527009027 active site 398527009028 phosphorylation site [posttranslational modification] 398527009029 intermolecular recognition site; other site 398527009030 dimerization interface [polypeptide binding]; other site 398527009031 Response regulator receiver domain; Region: Response_reg; pfam00072 398527009032 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527009033 active site 398527009034 phosphorylation site [posttranslational modification] 398527009035 intermolecular recognition site; other site 398527009036 dimerization interface [polypeptide binding]; other site 398527009037 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 398527009038 CheC-like family; Region: CheC; pfam04509 398527009039 PAS fold; Region: PAS; pfam00989 398527009040 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 398527009041 putative active site [active] 398527009042 heme pocket [chemical binding]; other site 398527009043 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 398527009044 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 398527009045 metal binding site [ion binding]; metal-binding site 398527009046 active site 398527009047 I-site; other site 398527009048 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 398527009049 active site lid residues [active] 398527009050 substrate binding pocket [chemical binding]; other site 398527009051 catalytic residues [active] 398527009052 substrate-Mg2+ binding site; other site 398527009053 aspartate-rich region 1; other site 398527009054 aspartate-rich region 2; other site 398527009055 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 398527009056 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 398527009057 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 398527009058 Active site cavity [active] 398527009059 catalytic acid [active] 398527009060 hypothetical protein; Provisional; Region: PRK07077 398527009061 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 398527009062 VacJ like lipoprotein; Region: VacJ; cl01073 398527009063 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 398527009064 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 398527009065 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 398527009066 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 398527009067 FeS/SAM binding site; other site 398527009068 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 398527009069 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 398527009070 LytB protein; Region: LYTB; pfam02401 398527009071 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 398527009072 active site lid residues [active] 398527009073 substrate binding pocket [chemical binding]; other site 398527009074 catalytic residues [active] 398527009075 substrate-Mg2+ binding site; other site 398527009076 aspartate-rich region 1; other site 398527009077 aspartate-rich region 2; other site 398527009078 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 398527009079 active site 398527009080 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 398527009081 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 398527009082 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 398527009083 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 398527009084 putative NADP binding site [chemical binding]; other site 398527009085 putative substrate binding site [chemical binding]; other site 398527009086 active site 398527009087 acylphosphatase; Provisional; Region: PRK14424 398527009088 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 398527009089 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 398527009090 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 398527009091 Predicted permeases [General function prediction only]; Region: RarD; COG2962 398527009092 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 398527009093 Predicted membrane protein [Function unknown]; Region: COG4539 398527009094 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 398527009095 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 398527009096 ligand binding site [chemical binding]; other site 398527009097 flexible hinge region; other site 398527009098 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 398527009099 putative switch regulator; other site 398527009100 non-specific DNA interactions [nucleotide binding]; other site 398527009101 DNA binding site [nucleotide binding] 398527009102 sequence specific DNA binding site [nucleotide binding]; other site 398527009103 putative cAMP binding site [chemical binding]; other site 398527009104 Methyltransferase domain; Region: Methyltransf_23; pfam13489 398527009105 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 398527009106 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 398527009107 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 398527009108 active site 398527009109 substrate binding site [chemical binding]; other site 398527009110 Mg2+ binding site [ion binding]; other site 398527009111 Protein of unknown function (DUF3564); Region: DUF3564; pfam12087 398527009112 Domain of unknown function (DUF4410); Region: DUF4410; pfam14366 398527009113 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 398527009114 acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397 398527009115 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 398527009116 Transcriptional regulator [Transcription]; Region: IclR; COG1414 398527009117 Bacterial transcriptional regulator; Region: IclR; pfam01614 398527009118 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 398527009119 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 398527009120 trimer interface [polypeptide binding]; other site 398527009121 eyelet of channel; other site 398527009122 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 398527009123 [2Fe-2S] cluster binding site [ion binding]; other site 398527009124 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 398527009125 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 398527009126 [2Fe-2S] cluster binding site [ion binding]; other site 398527009127 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 398527009128 hydrophobic ligand binding site; other site 398527009129 short chain dehydrogenase; Provisional; Region: PRK12939 398527009130 classical (c) SDRs; Region: SDR_c; cd05233 398527009131 NAD(P) binding site [chemical binding]; other site 398527009132 active site 398527009133 Cupin domain; Region: Cupin_2; pfam07883 398527009134 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 398527009135 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 398527009136 catalytic site [active] 398527009137 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 398527009138 Transcriptional regulator [Transcription]; Region: IclR; COG1414 398527009139 Bacterial transcriptional regulator; Region: IclR; pfam01614 398527009140 short chain dehydrogenase; Provisional; Region: PRK07062 398527009141 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 398527009142 putative NAD(P) binding site [chemical binding]; other site 398527009143 putative active site [active] 398527009144 hypothetical protein; Provisional; Region: PRK07064 398527009145 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 398527009146 PYR/PP interface [polypeptide binding]; other site 398527009147 dimer interface [polypeptide binding]; other site 398527009148 TPP binding site [chemical binding]; other site 398527009149 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 398527009150 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 398527009151 TPP-binding site [chemical binding]; other site 398527009152 L-aspartate dehydrogenase; Provisional; Region: PRK13303 398527009153 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 398527009154 Domain of unknown function DUF108; Region: DUF108; pfam01958 398527009155 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 398527009156 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 398527009157 NAD(P) binding site [chemical binding]; other site 398527009158 catalytic residues [active] 398527009159 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 398527009160 active site 398527009161 metal binding site [ion binding]; metal-binding site 398527009162 C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360 398527009163 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 398527009164 putative active site [active] 398527009165 putative metal binding site [ion binding]; other site 398527009166 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 398527009167 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 398527009168 benzoate transport; Region: 2A0115; TIGR00895 398527009169 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527009170 putative substrate translocation pore; other site 398527009171 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527009172 RHS Repeat; Region: RHS_repeat; pfam05593 398527009173 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 398527009174 RHS Repeat; Region: RHS_repeat; cl11982 398527009175 RHS Repeat; Region: RHS_repeat; cl11982 398527009176 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 398527009177 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 398527009178 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 398527009179 HSP70 interaction site [polypeptide binding]; other site 398527009180 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 398527009181 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 398527009182 nucleotide binding site [chemical binding]; other site 398527009183 putative NEF/HSP70 interaction site [polypeptide binding]; other site 398527009184 SBD interface [polypeptide binding]; other site 398527009185 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 398527009186 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 398527009187 Coenzyme A binding pocket [chemical binding]; other site 398527009188 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 398527009189 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 398527009190 hydroxyglutarate oxidase; Provisional; Region: PRK11728 398527009191 Protein of unknown function (DUF3562); Region: DUF3562; pfam12085 398527009192 EamA-like transporter family; Region: EamA; pfam00892 398527009193 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 398527009194 EamA-like transporter family; Region: EamA; pfam00892 398527009195 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 398527009196 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 398527009197 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 398527009198 Methyltransferase domain; Region: Methyltransf_11; pfam08241 398527009199 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 398527009200 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 398527009201 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 398527009202 DXD motif; other site 398527009203 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 398527009204 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 398527009205 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 398527009206 [2Fe-2S] cluster binding site [ion binding]; other site 398527009207 Rubredoxin; Region: Rubredoxin; pfam00301 398527009208 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 398527009209 iron binding site [ion binding]; other site 398527009210 short chain dehydrogenase; Provisional; Region: PRK06180 398527009211 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 398527009212 NADP binding site [chemical binding]; other site 398527009213 active site 398527009214 steroid binding site; other site 398527009215 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 398527009216 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527009217 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 398527009218 dimerization interface [polypeptide binding]; other site 398527009219 diaminopimelate decarboxylase; Provisional; Region: PRK11165 398527009220 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 398527009221 active site 398527009222 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 398527009223 substrate binding site [chemical binding]; other site 398527009224 catalytic residues [active] 398527009225 dimer interface [polypeptide binding]; other site 398527009226 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 398527009227 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527009228 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 398527009229 dimerization interface [polypeptide binding]; other site 398527009230 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 398527009231 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 398527009232 substrate binding pocket [chemical binding]; other site 398527009233 membrane-bound complex binding site; other site 398527009234 hinge residues; other site 398527009235 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like subfamily; subgroup includes Pseudomonas aeruginosa AotO; Region: M14_PaAOTO_like; cd06250 398527009236 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 398527009237 active site 398527009238 Zn binding site [ion binding]; other site 398527009239 Cupin domain; Region: Cupin_2; pfam07883 398527009240 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 398527009241 Phosphoesterase family; Region: Phosphoesterase; pfam04185 398527009242 Domain of unknown function (DUF756); Region: DUF756; pfam05506 398527009243 Domain of unknown function (DUF756); Region: DUF756; pfam05506 398527009244 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 398527009245 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 398527009246 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 398527009247 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 398527009248 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 398527009249 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 398527009250 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 398527009251 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 398527009252 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 398527009253 nucleotide binding site [chemical binding]; other site 398527009254 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 398527009255 substrate binding site [chemical binding]; other site 398527009256 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 398527009257 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 398527009258 active site 398527009259 catalytic tetrad [active] 398527009260 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 398527009261 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 398527009262 N-terminal plug; other site 398527009263 ligand-binding site [chemical binding]; other site 398527009264 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 398527009265 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295 398527009266 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 398527009267 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 398527009268 dimer interface [polypeptide binding]; other site 398527009269 phosphorylation site [posttranslational modification] 398527009270 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527009271 ATP binding site [chemical binding]; other site 398527009272 Mg2+ binding site [ion binding]; other site 398527009273 G-X-G motif; other site 398527009274 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 398527009275 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527009276 active site 398527009277 phosphorylation site [posttranslational modification] 398527009278 intermolecular recognition site; other site 398527009279 dimerization interface [polypeptide binding]; other site 398527009280 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 398527009281 GAF domain; Region: GAF; pfam01590 398527009282 PAS domain S-box; Region: sensory_box; TIGR00229 398527009283 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 398527009284 putative active site [active] 398527009285 heme pocket [chemical binding]; other site 398527009286 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 398527009287 dimer interface [polypeptide binding]; other site 398527009288 phosphorylation site [posttranslational modification] 398527009289 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527009290 ATP binding site [chemical binding]; other site 398527009291 Mg2+ binding site [ion binding]; other site 398527009292 G-X-G motif; other site 398527009293 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527009294 active site 398527009295 phosphorylation site [posttranslational modification] 398527009296 intermolecular recognition site; other site 398527009297 dimerization interface [polypeptide binding]; other site 398527009298 Response regulator receiver domain; Region: Response_reg; pfam00072 398527009299 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527009300 active site 398527009301 phosphorylation site [posttranslational modification] 398527009302 intermolecular recognition site; other site 398527009303 dimerization interface [polypeptide binding]; other site 398527009304 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 398527009305 putative FMN binding site [chemical binding]; other site 398527009306 High potential iron-sulfur protein; Region: HIPIP; pfam01355 398527009307 Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; pfam08883 398527009308 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 398527009309 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 398527009310 Coenzyme A binding pocket [chemical binding]; other site 398527009311 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 398527009312 YCII-related domain; Region: YCII; cl00999 398527009313 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 398527009314 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 398527009315 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 398527009316 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 398527009317 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 398527009318 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 398527009319 S-adenosylmethionine binding site [chemical binding]; other site 398527009320 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 398527009321 Domain of unknown function (DUF4337); Region: DUF4337; pfam14235 398527009322 Protein of unknown function (DUF1427); Region: DUF1427; pfam07235 398527009323 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 398527009324 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 398527009325 putative NAD(P) binding site [chemical binding]; other site 398527009326 Cupin domain; Region: Cupin_2; cl17218 398527009327 Helix-turn-helix domain; Region: HTH_18; pfam12833 398527009328 Predicted permeases [General function prediction only]; Region: COG0679 398527009329 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 398527009330 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527009331 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 398527009332 dimerization interface [polypeptide binding]; other site 398527009333 substrate binding pocket [chemical binding]; other site 398527009334 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 398527009335 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 398527009336 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 398527009337 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 398527009338 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 398527009339 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527009340 DNA-binding site [nucleotide binding]; DNA binding site 398527009341 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 398527009342 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527009343 homodimer interface [polypeptide binding]; other site 398527009344 catalytic residue [active] 398527009345 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 398527009346 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 398527009347 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG4551 398527009348 active site 398527009349 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 398527009350 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 398527009351 Coenzyme A binding pocket [chemical binding]; other site 398527009352 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 398527009353 active site 398527009354 dimer interface [polypeptide binding]; other site 398527009355 motif 1; other site 398527009356 motif 2; other site 398527009357 motif 3; other site 398527009358 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 398527009359 anticodon binding site; other site 398527009360 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 398527009361 amidohydrolase; Provisional; Region: PRK12393 398527009362 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 398527009363 active site 398527009364 putative substrate binding pocket [chemical binding]; other site 398527009365 xanthine permease; Region: pbuX; TIGR03173 398527009366 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 398527009367 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 398527009368 P-loop, Walker A motif; other site 398527009369 Base recognition motif; other site 398527009370 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 398527009371 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 398527009372 Flavoprotein; Region: Flavoprotein; pfam02441 398527009373 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 398527009374 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 398527009375 active site 398527009376 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 398527009377 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 398527009378 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527009379 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 398527009380 dimerization interface [polypeptide binding]; other site 398527009381 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 398527009382 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527009383 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 398527009384 dimerization interface [polypeptide binding]; other site 398527009385 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 398527009386 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 398527009387 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 398527009388 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 398527009389 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 398527009390 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 398527009391 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527009392 D-galactonate transporter; Region: 2A0114; TIGR00893 398527009393 putative substrate translocation pore; other site 398527009394 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 398527009395 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527009396 DNA-binding site [nucleotide binding]; DNA binding site 398527009397 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 398527009398 benzoate transport; Region: 2A0115; TIGR00895 398527009399 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527009400 putative substrate translocation pore; other site 398527009401 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 398527009402 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 398527009403 active site 398527009404 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 398527009405 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 398527009406 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 398527009407 ABC transporter; Region: ABC_tran_2; pfam12848 398527009408 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 398527009409 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 398527009410 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 398527009411 DEAD-like helicases superfamily; Region: DEXDc; smart00487 398527009412 ATP binding site [chemical binding]; other site 398527009413 Mg++ binding site [ion binding]; other site 398527009414 motif III; other site 398527009415 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 398527009416 nucleotide binding region [chemical binding]; other site 398527009417 ATP-binding site [chemical binding]; other site 398527009418 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 398527009419 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 398527009420 hexamer interface [polypeptide binding]; other site 398527009421 ligand binding site [chemical binding]; other site 398527009422 putative active site [active] 398527009423 NAD(P) binding site [chemical binding]; other site 398527009424 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527009425 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 398527009426 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527009427 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 398527009428 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527009429 Major Facilitator Superfamily; Region: MFS_1; pfam07690 398527009430 putative substrate translocation pore; other site 398527009431 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 398527009432 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 398527009433 putative C-terminal domain interface [polypeptide binding]; other site 398527009434 putative GSH binding site (G-site) [chemical binding]; other site 398527009435 putative dimer interface [polypeptide binding]; other site 398527009436 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 398527009437 putative N-terminal domain interface [polypeptide binding]; other site 398527009438 putative dimer interface [polypeptide binding]; other site 398527009439 putative substrate binding pocket (H-site) [chemical binding]; other site 398527009440 Dienelactone hydrolase family; Region: DLH; pfam01738 398527009441 SnoaL-like domain; Region: SnoaL_2; pfam12680 398527009442 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 398527009443 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 398527009444 acyl-activating enzyme (AAE) consensus motif; other site 398527009445 AMP binding site [chemical binding]; other site 398527009446 active site 398527009447 CoA binding site [chemical binding]; other site 398527009448 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 398527009449 homotrimer interaction site [polypeptide binding]; other site 398527009450 putative active site [active] 398527009451 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 398527009452 active site 398527009453 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 398527009454 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 398527009455 active site 398527009456 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 398527009457 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 398527009458 substrate binding site [chemical binding]; other site 398527009459 oxyanion hole (OAH) forming residues; other site 398527009460 trimer interface [polypeptide binding]; other site 398527009461 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 398527009462 MarR family; Region: MarR; pfam01047 398527009463 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 398527009464 classical (c) SDRs; Region: SDR_c; cd05233 398527009465 NAD(P) binding site [chemical binding]; other site 398527009466 active site 398527009467 salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255 398527009468 hypothetical protein; Provisional; Region: PRK07236 398527009469 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 398527009470 active site 398527009471 FMN binding site [chemical binding]; other site 398527009472 substrate binding site [chemical binding]; other site 398527009473 homotetramer interface [polypeptide binding]; other site 398527009474 catalytic residue [active] 398527009475 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 398527009476 Uncharacterized conserved protein [Function unknown]; Region: COG5361 398527009477 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 398527009478 Glycine-zipper containing OmpA-like membrane domain; Region: Gly-zipper_OmpA; pfam13436 398527009479 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 398527009480 homodimer interface [polypeptide binding]; other site 398527009481 oligomer interface [polypeptide binding]; other site 398527009482 chemical substrate binding site [chemical binding]; other site 398527009483 metal binding site [ion binding]; metal-binding site 398527009484 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527009485 Major Facilitator Superfamily; Region: MFS_1; pfam07690 398527009486 putative substrate translocation pore; other site 398527009487 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527009488 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 398527009489 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 398527009490 putative NAD(P) binding site [chemical binding]; other site 398527009491 putative active site [active] 398527009492 haloalkane dehalogenase; Provisional; Region: PRK03592 398527009493 Sulfatase; Region: Sulfatase; cl17466 398527009494 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 398527009495 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 398527009496 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 398527009497 CGNR zinc finger; Region: zf-CGNR; pfam11706 398527009498 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 398527009499 ArsC family; Region: ArsC; pfam03960 398527009500 catalytic residues [active] 398527009501 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 398527009502 arsenical-resistance protein; Region: acr3; TIGR00832 398527009503 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 398527009504 putative DNA binding site [nucleotide binding]; other site 398527009505 putative Zn2+ binding site [ion binding]; other site 398527009506 Src homology 2 (SH2) domain; Region: SH2; cl15255 398527009507 hydrophobic binding pocket [polypeptide binding]; other site 398527009508 Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979 398527009509 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 398527009510 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 398527009511 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 398527009512 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 398527009513 nitrile hydratase accessory protein; Region: nitrile_acc; TIGR03889 398527009514 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 398527009515 homotrimer interaction site [polypeptide binding]; other site 398527009516 putative active site [active] 398527009517 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895 398527009518 putative hydrophobic ligand binding site [chemical binding]; other site 398527009519 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG3837 398527009520 Domain of unknown function (DU1801); Region: DUF1801; cl17490 398527009521 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 398527009522 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 398527009523 active site 398527009524 HIGH motif; other site 398527009525 dimer interface [polypeptide binding]; other site 398527009526 KMSKS motif; other site 398527009527 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 398527009528 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 398527009529 NAD binding site [chemical binding]; other site 398527009530 catalytic residues [active] 398527009531 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527009532 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527009533 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 398527009534 putative effector binding pocket; other site 398527009535 putative dimerization interface [polypeptide binding]; other site 398527009536 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 398527009537 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 398527009538 metal binding site [ion binding]; metal-binding site 398527009539 active site 398527009540 I-site; other site 398527009541 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 398527009542 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 398527009543 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 398527009544 active site 398527009545 metal binding site [ion binding]; metal-binding site 398527009546 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 398527009547 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 398527009548 metal binding site 2 [ion binding]; metal-binding site 398527009549 putative DNA binding helix; other site 398527009550 metal binding site 1 [ion binding]; metal-binding site 398527009551 dimer interface [polypeptide binding]; other site 398527009552 structural Zn2+ binding site [ion binding]; other site 398527009553 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 398527009554 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 398527009555 trimer interface [polypeptide binding]; other site 398527009556 eyelet of channel; other site 398527009557 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 398527009558 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 398527009559 catalytic residues [active] 398527009560 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 398527009561 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 398527009562 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527009563 dimer interface [polypeptide binding]; other site 398527009564 conserved gate region; other site 398527009565 putative PBP binding loops; other site 398527009566 ABC-ATPase subunit interface; other site 398527009567 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 398527009568 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527009569 dimer interface [polypeptide binding]; other site 398527009570 conserved gate region; other site 398527009571 putative PBP binding loops; other site 398527009572 ABC-ATPase subunit interface; other site 398527009573 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 398527009574 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 398527009575 short chain dehydrogenase; Provisional; Region: PRK07074 398527009576 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 398527009577 NAD(P) binding site [chemical binding]; other site 398527009578 active site 398527009579 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 398527009580 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 398527009581 Walker A/P-loop; other site 398527009582 ATP binding site [chemical binding]; other site 398527009583 Q-loop/lid; other site 398527009584 ABC transporter signature motif; other site 398527009585 Walker B; other site 398527009586 D-loop; other site 398527009587 H-loop/switch region; other site 398527009588 TOBE domain; Region: TOBE_2; pfam08402 398527009589 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 398527009590 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 398527009591 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 398527009592 putative active site [active] 398527009593 Bacterial transcriptional regulator; Region: IclR; pfam01614 398527009594 Transcriptional regulator [Transcription]; Region: IclR; COG1414 398527009595 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 398527009596 Bacterial transcriptional regulator; Region: IclR; pfam01614 398527009597 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 398527009598 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 398527009599 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 398527009600 Protein of unknown function (DUF2783); Region: DUF2783; pfam10932 398527009601 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 398527009602 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 398527009603 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 398527009604 putative FMN binding site [chemical binding]; other site 398527009605 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 398527009606 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 398527009607 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 398527009608 putative DNA binding site [nucleotide binding]; other site 398527009609 putative Zn2+ binding site [ion binding]; other site 398527009610 AsnC family; Region: AsnC_trans_reg; pfam01037 398527009611 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 398527009612 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 398527009613 DNA binding site [nucleotide binding] 398527009614 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 398527009615 putative ligand binding site [chemical binding]; other site 398527009616 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 398527009617 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 398527009618 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 398527009619 DctM-like transporters; Region: DctM; pfam06808 398527009620 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 398527009621 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 398527009622 dimer interface [polypeptide binding]; other site 398527009623 substrate binding site [chemical binding]; other site 398527009624 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 398527009625 metal binding site [ion binding]; metal-binding site 398527009626 Ribulose 1,5-bisphosphate carboxylase, large subunit [Carbohydrate transport and metabolism]; Region: RbcL; COG1850 398527009627 Ribulose bisphosphate carboxylase like proteins from nonphototrophic bacteria; Region: RLP_NonPhot; cd08207 398527009628 dimer interface [polypeptide binding]; other site 398527009629 active site 398527009630 catalytic residue [active] 398527009631 metal binding site [ion binding]; metal-binding site 398527009632 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 398527009633 glucose-1-dehydrogenase; Provisional; Region: PRK08936 398527009634 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 398527009635 NAD binding site [chemical binding]; other site 398527009636 homodimer interface [polypeptide binding]; other site 398527009637 active site 398527009638 Protein of unknown function (DUF3309); Region: DUF3309; pfam11752 398527009639 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527009640 putative substrate translocation pore; other site 398527009641 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 398527009642 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 398527009643 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527009644 Major Facilitator Superfamily; Region: MFS_1; pfam07690 398527009645 putative substrate translocation pore; other site 398527009646 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527009647 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 398527009648 Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671 398527009649 type IVB pilus formation outer membrane protein, R64 PilN family; Region: pilus_B_mal_scr; TIGR02520 398527009650 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 398527009651 Type II/IV secretion system protein; Region: T2SE; pfam00437 398527009652 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 398527009653 Walker A motif; other site 398527009654 ATP binding site [chemical binding]; other site 398527009655 Walker B motif; other site 398527009656 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 398527009657 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 398527009658 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527009659 ATP binding site [chemical binding]; other site 398527009660 Mg2+ binding site [ion binding]; other site 398527009661 G-X-G motif; other site 398527009662 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527009663 active site 398527009664 phosphorylation site [posttranslational modification] 398527009665 intermolecular recognition site; other site 398527009666 dimerization interface [polypeptide binding]; other site 398527009667 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 398527009668 MarR family; Region: MarR; pfam01047 398527009669 MarR family; Region: MarR_2; cl17246 398527009670 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 398527009671 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 398527009672 FMN-binding pocket [chemical binding]; other site 398527009673 flavin binding motif; other site 398527009674 phosphate binding motif [ion binding]; other site 398527009675 beta-alpha-beta structure motif; other site 398527009676 NAD binding pocket [chemical binding]; other site 398527009677 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 398527009678 catalytic loop [active] 398527009679 iron binding site [ion binding]; other site 398527009680 Rieske non-heme iron oxygenase (RO) family, Phthalate 4,5-dioxygenase (PhDO)-like subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of PhDO and similar proteins including 3-chlorobenzoate 3; Region: Rieske_RO_Alpha_PhDO_like; cd03479 398527009681 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 398527009682 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 398527009683 hydrophobic ligand binding site; other site 398527009684 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527009685 D-galactonate transporter; Region: 2A0114; TIGR00893 398527009686 putative substrate translocation pore; other site 398527009687 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 398527009688 substrate binding pocket [chemical binding]; other site 398527009689 dimerization interface [polypeptide binding]; other site 398527009690 AAA domain; Region: AAA_22; pfam13401 398527009691 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527009692 Walker A motif; other site 398527009693 ATP binding site [chemical binding]; other site 398527009694 Walker B motif; other site 398527009695 arginine finger; other site 398527009696 Winged helix-turn helix; Region: HTH_29; pfam13551 398527009697 Integrase core domain; Region: rve; pfam00665 398527009698 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 398527009699 NAD(P) binding site [chemical binding]; other site 398527009700 active site 398527009701 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 398527009702 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527009703 active site 398527009704 phosphorylation site [posttranslational modification] 398527009705 intermolecular recognition site; other site 398527009706 dimerization interface [polypeptide binding]; other site 398527009707 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 398527009708 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527009709 active site 398527009710 phosphorylation site [posttranslational modification] 398527009711 intermolecular recognition site; other site 398527009712 dimerization interface [polypeptide binding]; other site 398527009713 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 398527009714 DNA binding residues [nucleotide binding] 398527009715 dimerization interface [polypeptide binding]; other site 398527009716 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 398527009717 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 398527009718 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 398527009719 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 398527009720 putative active site [active] 398527009721 heme pocket [chemical binding]; other site 398527009722 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 398527009723 putative active site [active] 398527009724 heme pocket [chemical binding]; other site 398527009725 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 398527009726 dimer interface [polypeptide binding]; other site 398527009727 phosphorylation site [posttranslational modification] 398527009728 Rci recombinase, C-terminal catalytic domain. Rci enzymes are found in IncI1 incompatibility group plasmids such as R64. These recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain...; Region: INT_Rci; cd00796 398527009729 catalytic residues [active] 398527009730 Int/Topo IB signature motif; other site 398527009731 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 398527009732 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 398527009733 non-specific DNA binding site [nucleotide binding]; other site 398527009734 salt bridge; other site 398527009735 sequence-specific DNA binding site [nucleotide binding]; other site 398527009736 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 398527009737 Toxin co-regulated pilus biosynthesis protein Q; Region: TcpQ; pfam10671 398527009738 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 398527009739 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 398527009740 non-specific DNA binding site [nucleotide binding]; other site 398527009741 salt bridge; other site 398527009742 sequence-specific DNA binding site [nucleotide binding]; other site 398527009743 conjugal transfer ATPase TrbE; Provisional; Region: PRK13873 398527009744 Zeta toxin; Region: Zeta_toxin; pfam06414 398527009745 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 398527009746 Methyltransferase domain; Region: Methyltransf_27; pfam13708 398527009747 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 398527009748 S-adenosylmethionine binding site [chemical binding]; other site 398527009749 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 398527009750 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12652 398527009751 plasmid partitioning protein; Provisional; Region: PRK13832 398527009752 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 398527009753 Domain of unknown function (DUF932); Region: DUF932; cl12129 398527009754 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 398527009755 active site 398527009756 catalytic residues [active] 398527009757 DNA binding site [nucleotide binding] 398527009758 Int/Topo IB signature motif; other site 398527009759 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 398527009760 active site 398527009761 catalytic residues [active] 398527009762 DNA binding site [nucleotide binding] 398527009763 Int/Topo IB signature motif; other site 398527009764 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 398527009765 Domain of unknown function (DUF932); Region: DUF932; cl12129 398527009766 KicB killing factor; Region: KicB; cl11468 398527009767 Protein of unknown function (DUF3717); Region: DUF3717; pfam12512 398527009768 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 398527009769 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 398527009770 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 398527009771 Walker A motif; other site 398527009772 ATP binding site [chemical binding]; other site 398527009773 Walker B motif; other site 398527009774 TrwC relaxase; Region: TrwC; pfam08751 398527009775 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 398527009776 AAA domain; Region: AAA_30; pfam13604 398527009777 Family description; Region: UvrD_C_2; pfam13538 398527009778 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 398527009779 N-acetyl-D-glucosamine binding site [chemical binding]; other site 398527009780 catalytic residue [active] 398527009781 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 398527009782 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 398527009783 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 398527009784 Type IV secretion system proteins; Region: T4SS; pfam07996 398527009785 P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791 398527009786 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 398527009787 VirB8 protein; Region: VirB8; pfam04335 398527009788 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 398527009789 VirB7 interaction site; other site 398527009790 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 398527009791 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 398527009792 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 398527009793 Walker A motif; other site 398527009794 ATP binding site [chemical binding]; other site 398527009795 Walker B motif; other site 398527009796 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 398527009797 catalytic site [active] 398527009798 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 398527009799 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 398527009800 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 398527009801 DNA binding site [nucleotide binding] 398527009802 Int/Topo IB signature motif; other site 398527009803 active site 398527009804 catalytic residues [active] 398527009805 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 398527009806 DNA binding site [nucleotide binding] 398527009807 active site 398527009808 Int/Topo IB signature motif; other site 398527009809 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 398527009810 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 398527009811 putative active site [active] 398527009812 catalytic site [active] 398527009813 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 398527009814 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 398527009815 active site 398527009816 DNA binding site [nucleotide binding] 398527009817 Int/Topo IB signature motif; other site 398527009818 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 398527009819 DNA binding site [nucleotide binding] 398527009820 Int/Topo IB signature motif; other site 398527009821 active site 398527009822 catalytic residues [active] 398527009823 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 398527009824 active site 398527009825 DNA binding site [nucleotide binding] 398527009826 Int/Topo IB signature motif; other site 398527009827 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 398527009828 putative active site [active] 398527009829 H-NS histone family; Region: Histone_HNS; pfam00816 398527009830 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 398527009831 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 398527009832 active site 398527009833 putative substrate binding region [chemical binding]; other site 398527009834 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 398527009835 DNA-binding interface [nucleotide binding]; DNA binding site 398527009836 Replication initiator protein A; Region: RPA; pfam10134 398527009837 SprT-like family; Region: SprT-like; pfam10263 398527009838 H-NS histone family; Region: Histone_HNS; pfam00816 398527009839 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 398527009840 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 398527009841 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 398527009842 N-acetyl-D-glucosamine binding site [chemical binding]; other site 398527009843 catalytic residue [active] 398527009844 DnaA N-terminal domain; Region: DnaA_N; pfam11638 398527009845 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 398527009846 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527009847 Walker A motif; other site 398527009848 ATP binding site [chemical binding]; other site 398527009849 Walker B motif; other site 398527009850 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 398527009851 arginine finger; other site 398527009852 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 398527009853 DnaA box-binding interface [nucleotide binding]; other site 398527009854 DNA polymerase III subunit beta; Validated; Region: PRK05643 398527009855 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 398527009856 putative DNA binding surface [nucleotide binding]; other site 398527009857 dimer interface [polypeptide binding]; other site 398527009858 beta-clamp/clamp loader binding surface; other site 398527009859 beta-clamp/translesion DNA polymerase binding surface; other site 398527009860 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 398527009861 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527009862 ATP binding site [chemical binding]; other site 398527009863 Mg2+ binding site [ion binding]; other site 398527009864 G-X-G motif; other site 398527009865 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 398527009866 anchoring element; other site 398527009867 dimer interface [polypeptide binding]; other site 398527009868 ATP binding site [chemical binding]; other site 398527009869 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 398527009870 active site 398527009871 putative metal-binding site [ion binding]; other site 398527009872 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 398527009873 PAAR motif; Region: PAAR_motif; pfam05488 398527009874 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 398527009875 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 398527009876 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 398527009877 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 398527009878 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 398527009879 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 398527009880 PAAR motif; Region: PAAR_motif; pfam05488 398527009881 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4924 398527009882 Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795 398527009883 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 398527009884 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 398527009885 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 398527009886 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 398527009887 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 398527009888 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 398527009889 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 398527009890 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 398527009891 putative active site [active] 398527009892 putative NTP binding site [chemical binding]; other site 398527009893 putative nucleic acid binding site [nucleotide binding]; other site 398527009894 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 398527009895 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527009896 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 398527009897 ethanolamine permease; Region: 2A0305; TIGR00908 398527009898 hypothetical protein; Provisional; Region: PHA02764 398527009899 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 398527009900 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 398527009901 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 398527009902 Protein of unknown function (DUF779); Region: DUF779; pfam05610 398527009903 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 398527009904 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 398527009905 NAD(P) binding site [chemical binding]; other site 398527009906 catalytic residues [active] 398527009907 Helix-turn-helix domain; Region: HTH_18; pfam12833 398527009908 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527009909 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 398527009910 Heavy-metal-associated domain; Region: HMA; pfam00403 398527009911 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 398527009912 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 398527009913 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 398527009914 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 398527009915 DNA binding residues [nucleotide binding] 398527009916 dimer interface [polypeptide binding]; other site 398527009917 putative metal binding site [ion binding]; other site 398527009918 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 398527009919 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 398527009920 ATP binding site [chemical binding]; other site 398527009921 Mg++ binding site [ion binding]; other site 398527009922 motif III; other site 398527009923 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 398527009924 nucleotide binding region [chemical binding]; other site 398527009925 ATP-binding site [chemical binding]; other site 398527009926 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 398527009927 putative RNA binding site [nucleotide binding]; other site 398527009928 putative aminotransferase; Provisional; Region: PRK12414 398527009929 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 398527009930 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527009931 homodimer interface [polypeptide binding]; other site 398527009932 catalytic residue [active] 398527009933 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 398527009934 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 398527009935 substrate binding pocket [chemical binding]; other site 398527009936 membrane-bound complex binding site; other site 398527009937 hinge residues; other site 398527009938 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 398527009939 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527009940 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 398527009941 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527009942 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 398527009943 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 398527009944 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527009945 putative substrate translocation pore; other site 398527009946 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 398527009947 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 398527009948 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527009949 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527009950 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 398527009951 putative effector binding pocket; other site 398527009952 putative dimerization interface [polypeptide binding]; other site 398527009953 putative amidase; Provisional; Region: PRK06169 398527009954 Amidase; Region: Amidase; pfam01425 398527009955 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 398527009956 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 398527009957 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 398527009958 allantoate amidohydrolase; Reviewed; Region: PRK09290 398527009959 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 398527009960 active site 398527009961 metal binding site [ion binding]; metal-binding site 398527009962 dimer interface [polypeptide binding]; other site 398527009963 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 398527009964 active site 398527009965 ATP binding site [chemical binding]; other site 398527009966 Phosphotransferase enzyme family; Region: APH; pfam01636 398527009967 substrate binding site [chemical binding]; other site 398527009968 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 398527009969 Phosphotransferase enzyme family; Region: APH; pfam01636 398527009970 active site 398527009971 ATP binding site [chemical binding]; other site 398527009972 substrate binding site [chemical binding]; other site 398527009973 dimer interface [polypeptide binding]; other site 398527009974 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 398527009975 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 398527009976 Na binding site [ion binding]; other site 398527009977 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 398527009978 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 398527009979 inhibitor-cofactor binding pocket; inhibition site 398527009980 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527009981 catalytic residue [active] 398527009982 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 398527009983 Periplasmic binding domain of amidase (AmiC) that belongs to the type I periplasmic binding fold protein family; Region: PBP1_AmiC; cd06357 398527009984 ligand binding site [chemical binding]; other site 398527009985 regulator interaction site; other site 398527009986 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 398527009987 ANTAR domain; Region: ANTAR; pfam03861 398527009988 Predicted amidohydrolase [General function prediction only]; Region: COG0388 398527009989 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_2; cd07580 398527009990 putative active site [active] 398527009991 catalytic triad [active] 398527009992 putative dimer interface [polypeptide binding]; other site 398527009993 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 398527009994 Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358 398527009995 putative ligand binding site [chemical binding]; other site 398527009996 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 398527009997 TM-ABC transporter signature motif; other site 398527009998 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 398527009999 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 398527010000 TM-ABC transporter signature motif; other site 398527010001 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 398527010002 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 398527010003 Walker A/P-loop; other site 398527010004 ATP binding site [chemical binding]; other site 398527010005 Q-loop/lid; other site 398527010006 ABC transporter signature motif; other site 398527010007 Walker B; other site 398527010008 D-loop; other site 398527010009 H-loop/switch region; other site 398527010010 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 398527010011 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 398527010012 Walker A/P-loop; other site 398527010013 ATP binding site [chemical binding]; other site 398527010014 Q-loop/lid; other site 398527010015 ABC transporter signature motif; other site 398527010016 Walker B; other site 398527010017 D-loop; other site 398527010018 H-loop/switch region; other site 398527010019 bifunctional urease subunit gamma/beta; Reviewed; Region: PRK13192 398527010020 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 398527010021 alpha-gamma subunit interface [polypeptide binding]; other site 398527010022 beta-gamma subunit interface [polypeptide binding]; other site 398527010023 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 398527010024 alpha-beta subunit interface [polypeptide binding]; other site 398527010025 urease subunit alpha; Reviewed; Region: ureC; PRK13207 398527010026 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 398527010027 active site 398527010028 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 398527010029 UreD urease accessory protein; Region: UreD; pfam01774 398527010030 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 398527010031 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cl03727 398527010032 dimer interface [polypeptide binding]; other site 398527010033 catalytic residues [active] 398527010034 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 398527010035 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 398527010036 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 398527010037 Transcriptional regulators [Transcription]; Region: PurR; COG1609 398527010038 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 398527010039 DNA binding site [nucleotide binding] 398527010040 domain linker motif; other site 398527010041 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 398527010042 putative dimerization interface [polypeptide binding]; other site 398527010043 putative ligand binding site [chemical binding]; other site 398527010044 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 398527010045 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 398527010046 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 398527010047 dimerization interface [polypeptide binding]; other site 398527010048 ligand binding site [chemical binding]; other site 398527010049 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 398527010050 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 398527010051 V4R domain; Region: V4R; cl15268 398527010052 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 398527010053 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 398527010054 active site 398527010055 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 398527010056 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 398527010057 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527010058 metabolite-proton symporter; Region: 2A0106; TIGR00883 398527010059 putative substrate translocation pore; other site 398527010060 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 398527010061 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 398527010062 trimer interface [polypeptide binding]; other site 398527010063 eyelet of channel; other site 398527010064 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 398527010065 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 398527010066 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 398527010067 zinc binding site [ion binding]; other site 398527010068 putative ligand binding site [chemical binding]; other site 398527010069 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 398527010070 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 398527010071 Walker A/P-loop; other site 398527010072 ATP binding site [chemical binding]; other site 398527010073 Q-loop/lid; other site 398527010074 ABC transporter signature motif; other site 398527010075 Walker B; other site 398527010076 D-loop; other site 398527010077 H-loop/switch region; other site 398527010078 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 398527010079 TM-ABC transporter signature motif; other site 398527010080 polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylases; Region: ubiX_pad; TIGR00421 398527010081 Flavoprotein; Region: Flavoprotein; pfam02441 398527010082 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 398527010083 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 398527010084 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527010085 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 398527010086 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 398527010087 NAD(P) binding site [chemical binding]; other site 398527010088 catalytic residues [active] 398527010089 Transcriptional regulators [Transcription]; Region: PurR; COG1609 398527010090 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 398527010091 DNA binding site [nucleotide binding] 398527010092 domain linker motif; other site 398527010093 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 398527010094 putative dimerization interface [polypeptide binding]; other site 398527010095 putative ligand binding site [chemical binding]; other site 398527010096 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 398527010097 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 398527010098 transcriptional activator TtdR; Provisional; Region: PRK09801 398527010099 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 398527010100 putative effector binding pocket; other site 398527010101 dimerization interface [polypeptide binding]; other site 398527010102 Domain of unknown function (DUF336); Region: DUF336; cl01249 398527010103 Major royal jelly protein; Region: MRJP; pfam03022 398527010104 putative transporter; Provisional; Region: PRK12382 398527010105 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527010106 putative substrate translocation pore; other site 398527010107 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 398527010108 PIN domain; Region: PIN_3; cl17397 398527010109 AAA domain; Region: AAA_22; pfam13401 398527010110 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527010111 Walker A motif; other site 398527010112 ATP binding site [chemical binding]; other site 398527010113 Walker B motif; other site 398527010114 arginine finger; other site 398527010115 Winged helix-turn helix; Region: HTH_29; pfam13551 398527010116 Integrase core domain; Region: rve; pfam00665 398527010117 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 398527010118 Walker A/P-loop; other site 398527010119 ATP binding site [chemical binding]; other site 398527010120 Q-loop/lid; other site 398527010121 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 398527010122 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 398527010123 ABC transporter signature motif; other site 398527010124 Walker B; other site 398527010125 D-loop; other site 398527010126 H-loop/switch region; other site 398527010127 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 398527010128 AAA domain; Region: AAA_21; pfam13304 398527010129 Walker A/P-loop; other site 398527010130 ATP binding site [chemical binding]; other site 398527010131 Q-loop/lid; other site 398527010132 ABC transporter signature motif; other site 398527010133 Walker B; other site 398527010134 D-loop; other site 398527010135 H-loop/switch region; other site 398527010136 recombination factor protein RarA; Reviewed; Region: PRK13342 398527010137 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527010138 Walker A motif; other site 398527010139 ATP binding site [chemical binding]; other site 398527010140 Walker B motif; other site 398527010141 arginine finger; other site 398527010142 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 398527010143 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 398527010144 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 398527010145 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 398527010146 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 398527010147 S-formylglutathione hydrolase; Region: PLN02442 398527010148 Protein of unknown function (DUF3422); Region: DUF3422; pfam11902 398527010149 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 398527010150 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 398527010151 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 398527010152 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 398527010153 substrate binding site [chemical binding]; other site 398527010154 catalytic Zn binding site [ion binding]; other site 398527010155 NAD binding site [chemical binding]; other site 398527010156 structural Zn binding site [ion binding]; other site 398527010157 dimer interface [polypeptide binding]; other site 398527010158 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 398527010159 putative metal binding site [ion binding]; other site 398527010160 putative homodimer interface [polypeptide binding]; other site 398527010161 putative homotetramer interface [polypeptide binding]; other site 398527010162 putative homodimer-homodimer interface [polypeptide binding]; other site 398527010163 putative allosteric switch controlling residues; other site 398527010164 glutamate--cysteine ligase; Provisional; Region: PRK02107 398527010165 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 398527010166 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 398527010167 NAD binding site [chemical binding]; other site 398527010168 catalytic Zn binding site [ion binding]; other site 398527010169 structural Zn binding site [ion binding]; other site 398527010170 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 398527010171 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 398527010172 conserved cys residue [active] 398527010173 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527010174 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527010175 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527010176 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527010177 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 398527010178 dimerization interface [polypeptide binding]; other site 398527010179 excinuclease ABC subunit B; Provisional; Region: PRK05298 398527010180 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 398527010181 ATP binding site [chemical binding]; other site 398527010182 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 398527010183 nucleotide binding region [chemical binding]; other site 398527010184 ATP-binding site [chemical binding]; other site 398527010185 Ultra-violet resistance protein B; Region: UvrB; pfam12344 398527010186 Protein of unknown function (DUF3422); Region: DUF3422; cl02073 398527010187 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 398527010188 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 398527010189 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 398527010190 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 398527010191 periplasmic protein; Provisional; Region: PRK10568 398527010192 BON domain; Region: BON; pfam04972 398527010193 Protein of unknown function, DUF488; Region: DUF488; pfam04343 398527010194 Autoinducer synthetase; Region: Autoind_synth; cl17404 398527010195 Autoinducer binding domain; Region: Autoind_bind; pfam03472 398527010196 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 398527010197 DNA binding residues [nucleotide binding] 398527010198 dimerization interface [polypeptide binding]; other site 398527010199 AAA domain; Region: AAA_22; pfam13401 398527010200 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527010201 Walker A motif; other site 398527010202 ATP binding site [chemical binding]; other site 398527010203 Walker B motif; other site 398527010204 arginine finger; other site 398527010205 Winged helix-turn helix; Region: HTH_29; pfam13551 398527010206 Integrase core domain; Region: rve; pfam00665 398527010207 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 398527010208 active site 398527010209 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 398527010210 active site 398527010211 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 398527010212 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 398527010213 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 398527010214 Acyl-CoA dehydrogenase, C-terminal domain; Region: Acyl-CoA_dh_1; pfam00441 398527010215 pyridoxal-dependent decarboxylase, exosortase A system-associated; Region: dCO2ase_PEP1; TIGR03099 398527010216 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839 398527010217 dimer interface [polypeptide binding]; other site 398527010218 active site 398527010219 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 398527010220 catalytic residues [active] 398527010221 substrate binding site [chemical binding]; other site 398527010222 acyl-CoA ligase (AMP-forming), exosortase A-associated; Region: ligase_PEP_1; TIGR03098 398527010223 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 398527010224 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 398527010225 acyl-activating enzyme (AAE) consensus motif; other site 398527010226 AMP binding site [chemical binding]; other site 398527010227 active site 398527010228 CoA binding site [chemical binding]; other site 398527010229 hypothetical protein; Validated; Region: PRK06840 398527010230 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 398527010231 dimer interface [polypeptide binding]; other site 398527010232 active site 398527010233 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 398527010234 active site 398527010235 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 398527010236 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 398527010237 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 398527010238 active site 398527010239 Transcriptional regulators [Transcription]; Region: FadR; COG2186 398527010240 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527010241 DNA-binding site [nucleotide binding]; DNA binding site 398527010242 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 398527010243 putative amidase; Provisional; Region: PRK06169 398527010244 Amidase; Region: Amidase; pfam01425 398527010245 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 398527010246 non-specific DNA binding site [nucleotide binding]; other site 398527010247 salt bridge; other site 398527010248 sequence-specific DNA binding site [nucleotide binding]; other site 398527010249 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 398527010250 non-specific DNA binding site [nucleotide binding]; other site 398527010251 salt bridge; other site 398527010252 sequence-specific DNA binding site [nucleotide binding]; other site 398527010253 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 398527010254 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 398527010255 TM-ABC transporter signature motif; other site 398527010256 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 398527010257 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 398527010258 TM-ABC transporter signature motif; other site 398527010259 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 398527010260 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 398527010261 Walker A/P-loop; other site 398527010262 ATP binding site [chemical binding]; other site 398527010263 Q-loop/lid; other site 398527010264 ABC transporter signature motif; other site 398527010265 Walker B; other site 398527010266 D-loop; other site 398527010267 H-loop/switch region; other site 398527010268 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 398527010269 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 398527010270 Walker A/P-loop; other site 398527010271 ATP binding site [chemical binding]; other site 398527010272 Q-loop/lid; other site 398527010273 ABC transporter signature motif; other site 398527010274 Walker B; other site 398527010275 D-loop; other site 398527010276 H-loop/switch region; other site 398527010277 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 398527010278 Type I periplasmic components of amide-binding protein (AmiC) and the active transport system for short-chain and urea (FmdDEF); Region: PBP1_AmiC_like; cd06331 398527010279 ligand binding site [chemical binding]; other site 398527010280 putative amidase; Provisional; Region: PRK06169 398527010281 Amidase; Region: Amidase; cl11426 398527010282 Amino acid synthesis; Region: AA_synth; pfam06684 398527010283 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 398527010284 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 398527010285 trimer interface [polypeptide binding]; other site 398527010286 eyelet of channel; other site 398527010287 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 398527010288 Condensation domain; Region: Condensation; pfam00668 398527010289 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 398527010290 oligomeric interface; other site 398527010291 putative active site [active] 398527010292 homodimer interface [polypeptide binding]; other site 398527010293 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 398527010294 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 398527010295 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 398527010296 N-acetyl-D-glucosamine binding site [chemical binding]; other site 398527010297 catalytic residue [active] 398527010298 TrbC/VIRB2 family; Region: TrbC; pfam04956 398527010299 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 398527010300 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 398527010301 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 398527010302 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 398527010303 Type IV secretion system proteins; Region: T4SS; pfam07996 398527010304 P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791 398527010305 VirB8 protein; Region: VirB8; pfam04335 398527010306 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 398527010307 VirB7 interaction site; other site 398527010308 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 398527010309 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 398527010310 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 398527010311 Walker A motif; other site 398527010312 hexamer interface [polypeptide binding]; other site 398527010313 ATP binding site [chemical binding]; other site 398527010314 Walker B motif; other site 398527010315 conjugal transfer coupling protein TraG; Provisional; Region: PRK13876 398527010316 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 398527010317 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 398527010318 Walker A motif; other site 398527010319 ATP binding site [chemical binding]; other site 398527010320 Walker B motif; other site 398527010321 Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707 398527010322 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 398527010323 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 398527010324 active site 398527010325 metal binding site [ion binding]; metal-binding site 398527010326 interdomain interaction site; other site 398527010327 type IV secretion system T-DNA border endonuclease VirD2; Provisional; Region: PRK13863 398527010328 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 398527010329 Domain of unknown function (DUF3331); Region: DUF3331; pfam11811 398527010330 acetyacetyl-CoA reductase; Provisional; Region: PRK12938 398527010331 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 398527010332 NAD(P) binding site [chemical binding]; other site 398527010333 homotetramer interface [polypeptide binding]; other site 398527010334 homodimer interface [polypeptide binding]; other site 398527010335 active site 398527010336 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 398527010337 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 398527010338 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 398527010339 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 398527010340 metal binding site [ion binding]; metal-binding site 398527010341 active site 398527010342 I-site; other site 398527010343 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 398527010344 PAS domain S-box; Region: sensory_box; TIGR00229 398527010345 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 398527010346 putative active site [active] 398527010347 heme pocket [chemical binding]; other site 398527010348 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 398527010349 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 398527010350 dimer interface [polypeptide binding]; other site 398527010351 phosphorylation site [posttranslational modification] 398527010352 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527010353 ATP binding site [chemical binding]; other site 398527010354 Mg2+ binding site [ion binding]; other site 398527010355 G-X-G motif; other site 398527010356 Response regulator receiver domain; Region: Response_reg; pfam00072 398527010357 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527010358 active site 398527010359 phosphorylation site [posttranslational modification] 398527010360 intermolecular recognition site; other site 398527010361 dimerization interface [polypeptide binding]; other site 398527010362 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 398527010363 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527010364 active site 398527010365 phosphorylation site [posttranslational modification] 398527010366 intermolecular recognition site; other site 398527010367 dimerization interface [polypeptide binding]; other site 398527010368 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 398527010369 Zn2+ binding site [ion binding]; other site 398527010370 Mg2+ binding site [ion binding]; other site 398527010371 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 398527010372 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 398527010373 trimer interface [polypeptide binding]; other site 398527010374 eyelet of channel; other site 398527010375 benzoate transport; Region: 2A0115; TIGR00895 398527010376 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527010377 putative substrate translocation pore; other site 398527010378 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527010379 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 398527010380 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 398527010381 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 398527010382 active site 398527010383 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 398527010384 Transcriptional regulator [Transcription]; Region: IclR; COG1414 398527010385 Bacterial transcriptional regulator; Region: IclR; pfam01614 398527010386 transposase/IS protein; Provisional; Region: PRK09183 398527010387 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527010388 Walker A motif; other site 398527010389 ATP binding site [chemical binding]; other site 398527010390 Walker B motif; other site 398527010391 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 398527010392 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527010393 Walker A motif; other site 398527010394 ATP binding site [chemical binding]; other site 398527010395 Walker B motif; other site 398527010396 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 398527010397 Integrase core domain; Region: rve; pfam00665 398527010398 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 398527010399 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 398527010400 putative active site [active] 398527010401 putative PHP Thumb interface [polypeptide binding]; other site 398527010402 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 398527010403 generic binding surface I; other site 398527010404 generic binding surface II; other site 398527010405 DNA Polymerase Y-family; Region: PolY_like; cd03468 398527010406 active site 398527010407 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 398527010408 DNA binding site [nucleotide binding] 398527010409 Uncharacterized conserved protein [Function unknown]; Region: COG4544 398527010410 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 398527010411 putative DNA binding site [nucleotide binding]; other site 398527010412 putative Zn2+ binding site [ion binding]; other site 398527010413 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 398527010414 Low molecular weight phosphatase family; Region: LMWPc; cd00115 398527010415 active site 398527010416 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 398527010417 arsenical-resistance protein; Region: acr3; TIGR00832 398527010418 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 398527010419 Coenzyme A binding pocket [chemical binding]; other site 398527010420 arsenical resistance protein ArsH; Region: resist_ArsH; TIGR02690 398527010421 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 398527010422 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527010423 Major Facilitator Superfamily; Region: MFS_1; pfam07690 398527010424 putative substrate translocation pore; other site 398527010425 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 398527010426 DNA binding site [nucleotide binding] 398527010427 active site 398527010428 Int/Topo IB signature motif; other site 398527010429 catalytic residues [active] 398527010430 Putative phage integrase; Region: Phage_Integr_2; pfam13009 398527010431 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 398527010432 active site 398527010433 Int/Topo IB signature motif; other site 398527010434 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 398527010435 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 398527010436 dimer interface [polypeptide binding]; other site 398527010437 putative CheW interface [polypeptide binding]; other site 398527010438 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 398527010439 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 398527010440 heme binding site [chemical binding]; other site 398527010441 ferroxidase pore; other site 398527010442 ferroxidase diiron center [ion binding]; other site 398527010443 cyanate hydratase; Validated; Region: PRK02866 398527010444 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 398527010445 oligomer interface [polypeptide binding]; other site 398527010446 active site 398527010447 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 398527010448 classical (c) SDRs; Region: SDR_c; cd05233 398527010449 NAD(P) binding site [chemical binding]; other site 398527010450 active site 398527010451 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527010452 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527010453 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 398527010454 putative effector binding pocket; other site 398527010455 dimerization interface [polypeptide binding]; other site 398527010456 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 398527010457 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 398527010458 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 398527010459 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 398527010460 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 398527010461 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 398527010462 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 398527010463 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527010464 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527010465 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 398527010466 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 398527010467 dimer interface [polypeptide binding]; other site 398527010468 putative CheW interface [polypeptide binding]; other site 398527010469 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 398527010470 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 398527010471 metal binding site [ion binding]; metal-binding site 398527010472 active site 398527010473 I-site; other site 398527010474 Transposase; Region: DEDD_Tnp_IS110; pfam01548 398527010475 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 398527010476 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 398527010477 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 398527010478 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 398527010479 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 398527010480 active site 398527010481 DNA binding site [nucleotide binding] 398527010482 Int/Topo IB signature motif; other site 398527010483 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 398527010484 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 398527010485 active site 398527010486 DNA binding site [nucleotide binding] 398527010487 Int/Topo IB signature motif; other site 398527010488 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 398527010489 INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190 398527010490 Int/Topo IB signature motif; other site 398527010491 Domain of unknown function (DUF932); Region: DUF932; cl12129 398527010492 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 398527010493 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 398527010494 active site 398527010495 catalytic residues [active] 398527010496 DNA binding site [nucleotide binding] 398527010497 Int/Topo IB signature motif; other site 398527010498 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 398527010499 active site 398527010500 catalytic residues [active] 398527010501 DNA binding site [nucleotide binding] 398527010502 Int/Topo IB signature motif; other site 398527010503 Domain of unknown function (DUF932); Region: DUF932; cl12129 398527010504 Cupin domain; Region: Cupin_2; cl17218 398527010505 Helix-turn-helix domain; Region: HTH_18; pfam12833 398527010506 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 398527010507 transmembrane helices; other site 398527010508 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 398527010509 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 398527010510 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527010511 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 398527010512 dimerization interface [polypeptide binding]; other site 398527010513 substrate binding pocket [chemical binding]; other site 398527010514 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 398527010515 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 398527010516 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 398527010517 catalytic triad [active] 398527010518 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 398527010519 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 398527010520 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 398527010521 H-NS histone family; Region: Histone_HNS; pfam00816 398527010522 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 398527010523 integrase; Provisional; Region: int; PHA02601 398527010524 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 398527010525 active site 398527010526 DNA binding site [nucleotide binding] 398527010527 Int/Topo IB signature motif; other site 398527010528 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 398527010529 dimerization interface [polypeptide binding]; other site 398527010530 putative DNA binding site [nucleotide binding]; other site 398527010531 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 398527010532 putative Zn2+ binding site [ion binding]; other site 398527010533 AsnC family; Region: AsnC_trans_reg; pfam01037 398527010534 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 398527010535 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 398527010536 catalytic residue [active] 398527010537 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 398527010538 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 398527010539 active site 398527010540 DNA polymerase IV; Validated; Region: PRK02406 398527010541 DNA binding site [nucleotide binding] 398527010542 SnoaL-like domain; Region: SnoaL_2; pfam12680 398527010543 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 398527010544 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 398527010545 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 398527010546 Glutathione S-transferase, C-terminal domain; Region: GST_C; pfam00043 398527010547 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 398527010548 dimerization interface [polypeptide binding]; other site 398527010549 putative DNA binding site [nucleotide binding]; other site 398527010550 putative Zn2+ binding site [ion binding]; other site 398527010551 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 398527010552 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527010553 putative substrate translocation pore; other site 398527010554 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 398527010555 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 398527010556 Cupin domain; Region: Cupin_2; pfam07883 398527010557 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 398527010558 hydroxyglutarate oxidase; Provisional; Region: PRK11728 398527010559 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 398527010560 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 398527010561 active site 398527010562 nucleotide binding site [chemical binding]; other site 398527010563 HIGH motif; other site 398527010564 KMSKS motif; other site 398527010565 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 398527010566 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 398527010567 putative catalytic site [active] 398527010568 putative metal binding site [ion binding]; other site 398527010569 putative phosphate binding site [ion binding]; other site 398527010570 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527010571 Major Facilitator Superfamily; Region: MFS_1; pfam07690 398527010572 putative substrate translocation pore; other site 398527010573 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 398527010574 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 398527010575 P-loop, Walker A motif; other site 398527010576 Base recognition motif; other site 398527010577 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 398527010578 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 398527010579 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 398527010580 intersubunit interface [polypeptide binding]; other site 398527010581 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 398527010582 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 398527010583 Walker A/P-loop; other site 398527010584 ATP binding site [chemical binding]; other site 398527010585 Q-loop/lid; other site 398527010586 ABC transporter signature motif; other site 398527010587 Walker B; other site 398527010588 D-loop; other site 398527010589 H-loop/switch region; other site 398527010590 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 398527010591 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 398527010592 ABC-ATPase subunit interface; other site 398527010593 dimer interface [polypeptide binding]; other site 398527010594 putative PBP binding regions; other site 398527010595 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 398527010596 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 398527010597 Fic family protein [Function unknown]; Region: COG3177 398527010598 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 398527010599 Fic/DOC family; Region: Fic; pfam02661 398527010600 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 398527010601 CoenzymeA binding site [chemical binding]; other site 398527010602 subunit interaction site [polypeptide binding]; other site 398527010603 PHB binding site; other site 398527010604 Patatin-like phospholipase; Region: Patatin; pfam01734 398527010605 active site 398527010606 nucleophile elbow; other site 398527010607 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 398527010608 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 398527010609 dimerization interface [polypeptide binding]; other site 398527010610 NAD binding site [chemical binding]; other site 398527010611 ligand binding site [chemical binding]; other site 398527010612 catalytic site [active] 398527010613 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 398527010614 active site 398527010615 substrate-binding site [chemical binding]; other site 398527010616 metal-binding site [ion binding] 398527010617 GTP binding site [chemical binding]; other site 398527010618 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527010619 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527010620 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 398527010621 putative effector binding pocket; other site 398527010622 dimerization interface [polypeptide binding]; other site 398527010623 DNA topoisomerase III; Validated; Region: PRK08173 398527010624 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 398527010625 active site 398527010626 putative interdomain interaction site [polypeptide binding]; other site 398527010627 putative metal-binding site [ion binding]; other site 398527010628 putative nucleotide binding site [chemical binding]; other site 398527010629 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 398527010630 domain I; other site 398527010631 DNA binding groove [nucleotide binding] 398527010632 phosphate binding site [ion binding]; other site 398527010633 domain II; other site 398527010634 domain III; other site 398527010635 nucleotide binding site [chemical binding]; other site 398527010636 catalytic site [active] 398527010637 domain IV; other site 398527010638 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 398527010639 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 398527010640 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 398527010641 catalytic residues [active] 398527010642 DNA protecting protein DprA; Region: dprA; TIGR00732 398527010643 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 398527010644 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 398527010645 active site 398527010646 catalytic residues [active] 398527010647 metal binding site [ion binding]; metal-binding site 398527010648 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 398527010649 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 398527010650 putative active site [active] 398527010651 substrate binding site [chemical binding]; other site 398527010652 putative cosubstrate binding site; other site 398527010653 catalytic site [active] 398527010654 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 398527010655 substrate binding site [chemical binding]; other site 398527010656 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 398527010657 M48 family peptidase; Provisional; Region: PRK03001 398527010658 16S rRNA methyltransferase B; Provisional; Region: PRK10901 398527010659 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 398527010660 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 398527010661 S-adenosylmethionine binding site [chemical binding]; other site 398527010662 Domain of unknown function (DUF4390); Region: DUF4390; pfam14334 398527010663 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 398527010664 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 398527010665 dimerization interface [polypeptide binding]; other site 398527010666 PAS domain; Region: PAS; smart00091 398527010667 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 398527010668 dimer interface [polypeptide binding]; other site 398527010669 phosphorylation site [posttranslational modification] 398527010670 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527010671 ATP binding site [chemical binding]; other site 398527010672 Mg2+ binding site [ion binding]; other site 398527010673 G-X-G motif; other site 398527010674 Response regulator receiver domain; Region: Response_reg; pfam00072 398527010675 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527010676 active site 398527010677 phosphorylation site [posttranslational modification] 398527010678 intermolecular recognition site; other site 398527010679 dimerization interface [polypeptide binding]; other site 398527010680 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 398527010681 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 398527010682 Ligand Binding Site [chemical binding]; other site 398527010683 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 398527010684 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 398527010685 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 398527010686 active site 398527010687 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 398527010688 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 398527010689 Sel1 repeat; Region: Sel1; cl02723 398527010690 Sel1-like repeats; Region: SEL1; smart00671 398527010691 Sel1-like repeats; Region: SEL1; smart00671 398527010692 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 398527010693 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 398527010694 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 398527010695 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 398527010696 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 398527010697 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 398527010698 rod shape-determining protein MreC; Region: MreC; pfam04085 398527010699 rod shape-determining protein MreB; Provisional; Region: PRK13927 398527010700 MreB and similar proteins; Region: MreB_like; cd10225 398527010701 nucleotide binding site [chemical binding]; other site 398527010702 Mg binding site [ion binding]; other site 398527010703 putative protofilament interaction site [polypeptide binding]; other site 398527010704 RodZ interaction site [polypeptide binding]; other site 398527010705 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 398527010706 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 398527010707 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 398527010708 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 398527010709 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 398527010710 GatB domain; Region: GatB_Yqey; smart00845 398527010711 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 398527010712 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 398527010713 putative active site [active] 398527010714 putative catalytic site [active] 398527010715 putative DNA binding site [nucleotide binding]; other site 398527010716 putative phosphate binding site [ion binding]; other site 398527010717 metal binding site A [ion binding]; metal-binding site 398527010718 putative AP binding site [nucleotide binding]; other site 398527010719 putative metal binding site B [ion binding]; other site 398527010720 Peptidase family M48; Region: Peptidase_M48; cl12018 398527010721 muropeptide transporter; Reviewed; Region: ampG; PRK11902 398527010722 AmpG-like permease; Region: 2A0125; TIGR00901 398527010723 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 398527010724 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 398527010725 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 398527010726 division inhibitor protein; Provisional; Region: slmA; PRK09480 398527010727 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 398527010728 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 398527010729 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 398527010730 motif II; other site 398527010731 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 398527010732 feedback inhibition sensing region; other site 398527010733 homohexameric interface [polypeptide binding]; other site 398527010734 nucleotide binding site [chemical binding]; other site 398527010735 N-acetyl-L-glutamate binding site [chemical binding]; other site 398527010736 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 398527010737 TPR motif; other site 398527010738 TPR repeat; Region: TPR_11; pfam13414 398527010739 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 398527010740 TPR motif; other site 398527010741 binding surface 398527010742 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 398527010743 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 398527010744 dimer interface [polypeptide binding]; other site 398527010745 phosphorylation site [posttranslational modification] 398527010746 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527010747 ATP binding site [chemical binding]; other site 398527010748 Mg2+ binding site [ion binding]; other site 398527010749 G-X-G motif; other site 398527010750 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 398527010751 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527010752 active site 398527010753 phosphorylation site [posttranslational modification] 398527010754 intermolecular recognition site; other site 398527010755 dimerization interface [polypeptide binding]; other site 398527010756 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 398527010757 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 398527010758 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527010759 Walker A motif; other site 398527010760 ATP binding site [chemical binding]; other site 398527010761 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527010762 Walker B motif; other site 398527010763 arginine finger; other site 398527010764 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 398527010765 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 398527010766 active site 398527010767 HslU subunit interaction site [polypeptide binding]; other site 398527010768 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 398527010769 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 398527010770 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 398527010771 P-loop, Walker A motif; other site 398527010772 Base recognition motif; other site 398527010773 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 398527010774 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 398527010775 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 398527010776 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 398527010777 putative RNA binding site [nucleotide binding]; other site 398527010778 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 398527010779 S-adenosylmethionine binding site [chemical binding]; other site 398527010780 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 398527010781 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 398527010782 active site 398527010783 DNA binding site [nucleotide binding] 398527010784 Int/Topo IB signature motif; other site 398527010785 Protein of unknown function, DUF484; Region: DUF484; cl17449 398527010786 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 398527010787 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 398527010788 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 398527010789 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 398527010790 putative acyl-acceptor binding pocket; other site 398527010791 S-adenosylmethionine synthetase; Validated; Region: PRK05250 398527010792 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 398527010793 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 398527010794 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 398527010795 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 398527010796 Protein of unknown function (DUF3185); Region: DUF3185; pfam11381 398527010797 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 398527010798 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 398527010799 active site 398527010800 catalytic tetrad [active] 398527010801 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 398527010802 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527010803 putative substrate translocation pore; other site 398527010804 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 398527010805 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 398527010806 HlyD family secretion protein; Region: HlyD_3; pfam13437 398527010807 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 398527010808 Protein export membrane protein; Region: SecD_SecF; cl14618 398527010809 serine/threonine protein kinase; Provisional; Region: PRK11768 398527010810 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 398527010811 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 398527010812 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 398527010813 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 398527010814 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 398527010815 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 398527010816 XdhC Rossmann domain; Region: XdhC_C; pfam13478 398527010817 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 398527010818 putative hydrophobic ligand binding site [chemical binding]; other site 398527010819 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 398527010820 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 398527010821 metal ion-dependent adhesion site (MIDAS); other site 398527010822 MoxR-like ATPases [General function prediction only]; Region: COG0714 398527010823 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527010824 Walker A motif; other site 398527010825 ATP binding site [chemical binding]; other site 398527010826 Walker B motif; other site 398527010827 arginine finger; other site 398527010828 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 398527010829 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 398527010830 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 398527010831 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 398527010832 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 398527010833 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 398527010834 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 398527010835 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 398527010836 amino acid transporter; Region: 2A0306; TIGR00909 398527010837 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 398527010838 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 398527010839 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527010840 active site 398527010841 phosphorylation site [posttranslational modification] 398527010842 intermolecular recognition site; other site 398527010843 dimerization interface [polypeptide binding]; other site 398527010844 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 398527010845 DNA binding residues [nucleotide binding] 398527010846 dimerization interface [polypeptide binding]; other site 398527010847 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 398527010848 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527010849 ATP binding site [chemical binding]; other site 398527010850 Mg2+ binding site [ion binding]; other site 398527010851 G-X-G motif; other site 398527010852 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 398527010853 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 398527010854 FAD binding pocket [chemical binding]; other site 398527010855 FAD binding motif [chemical binding]; other site 398527010856 phosphate binding motif [ion binding]; other site 398527010857 beta-alpha-beta structure motif; other site 398527010858 NAD binding pocket [chemical binding]; other site 398527010859 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 398527010860 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 398527010861 TM-ABC transporter signature motif; other site 398527010862 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 398527010863 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 398527010864 TM-ABC transporter signature motif; other site 398527010865 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 398527010866 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 398527010867 Walker A/P-loop; other site 398527010868 ATP binding site [chemical binding]; other site 398527010869 Q-loop/lid; other site 398527010870 ABC transporter signature motif; other site 398527010871 Walker B; other site 398527010872 D-loop; other site 398527010873 H-loop/switch region; other site 398527010874 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 398527010875 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 398527010876 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 398527010877 putative ligand binding site [chemical binding]; other site 398527010878 Transcriptional regulators [Transcription]; Region: PurR; COG1609 398527010879 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 398527010880 DNA binding site [nucleotide binding] 398527010881 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 398527010882 putative dimerization interface [polypeptide binding]; other site 398527010883 putative ligand binding site [chemical binding]; other site 398527010884 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 398527010885 active site 398527010886 catalytic residues [active] 398527010887 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 398527010888 putative catalytic site [active] 398527010889 putative phosphate binding site [ion binding]; other site 398527010890 putative metal binding site [ion binding]; other site 398527010891 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527010892 Walker A motif; other site 398527010893 ATP binding site [chemical binding]; other site 398527010894 Walker B motif; other site 398527010895 arginine finger; other site 398527010896 Predicted dehydrogenase [General function prediction only]; Region: COG0579 398527010897 hydroxyglutarate oxidase; Provisional; Region: PRK11728 398527010898 High potential iron-sulfur protein; Region: HIPIP; pfam01355 398527010899 citrate-proton symporter; Provisional; Region: PRK15075 398527010900 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527010901 putative substrate translocation pore; other site 398527010902 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 398527010903 Amidase; Region: Amidase; cl11426 398527010904 Dienelactone hydrolase family; Region: DLH; pfam01738 398527010905 Nitronate monooxygenase; Region: NMO; pfam03060 398527010906 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 398527010907 FMN binding site [chemical binding]; other site 398527010908 substrate binding site [chemical binding]; other site 398527010909 putative catalytic residue [active] 398527010910 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 398527010911 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 398527010912 dimerization interface [polypeptide binding]; other site 398527010913 ligand binding site [chemical binding]; other site 398527010914 Cupin-like domain; Region: Cupin_8; pfam13621 398527010915 Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883 398527010916 H-NS histone family; Region: Histone_HNS; pfam00816 398527010917 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 398527010918 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 398527010919 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 398527010920 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 398527010921 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 398527010922 putative DNA binding site [nucleotide binding]; other site 398527010923 putative Zn2+ binding site [ion binding]; other site 398527010924 AsnC family; Region: AsnC_trans_reg; pfam01037 398527010925 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 398527010926 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 398527010927 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 398527010928 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 398527010929 Predicted methyltransferases [General function prediction only]; Region: COG0313 398527010930 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 398527010931 putative SAM binding site [chemical binding]; other site 398527010932 putative homodimer interface [polypeptide binding]; other site 398527010933 hypothetical protein; Provisional; Region: PRK14673 398527010934 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 398527010935 dimer interface [polypeptide binding]; other site 398527010936 active site 398527010937 outer membrane lipoprotein; Provisional; Region: PRK11023 398527010938 BON domain; Region: BON; pfam04972 398527010939 Cytochrome c; Region: Cytochrom_C; cl11414 398527010940 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 398527010941 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 398527010942 dimerization interface [polypeptide binding]; other site 398527010943 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 398527010944 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 398527010945 dimer interface [polypeptide binding]; other site 398527010946 putative CheW interface [polypeptide binding]; other site 398527010947 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 398527010948 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 398527010949 metal binding site [ion binding]; metal-binding site 398527010950 active site 398527010951 I-site; other site 398527010952 Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998 398527010953 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 398527010954 HAMP domain; Region: HAMP; pfam00672 398527010955 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 398527010956 dimer interface [polypeptide binding]; other site 398527010957 putative CheW interface [polypeptide binding]; other site 398527010958 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 398527010959 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 398527010960 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 398527010961 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 398527010962 CutC family; Region: CutC; cl01218 398527010963 2-oxoacid ferredoxin oxidoreductase; Provisional; Region: PRK13030 398527010964 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 398527010965 dimer interface [polypeptide binding]; other site 398527010966 PYR/PP interface [polypeptide binding]; other site 398527010967 TPP binding site [chemical binding]; other site 398527010968 substrate binding site [chemical binding]; other site 398527010969 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 398527010970 TPP-binding site [chemical binding]; other site 398527010971 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 398527010972 haemagglutination activity domain; Region: Haemagg_act; pfam05860 398527010973 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 398527010974 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 398527010975 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 398527010976 Inward rectifier potassium channel; Region: IRK; pfam01007 398527010977 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 398527010978 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 398527010979 putative substrate binding site [chemical binding]; other site 398527010980 putative ATP binding site [chemical binding]; other site 398527010981 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 398527010982 dimerization interface [polypeptide binding]; other site 398527010983 putative active cleft [active] 398527010984 Transcriptional regulators [Transcription]; Region: PurR; COG1609 398527010985 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 398527010986 DNA binding site [nucleotide binding] 398527010987 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 398527010988 ligand binding site [chemical binding]; other site 398527010989 dimerization interface [polypeptide binding]; other site 398527010990 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 398527010991 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598 398527010992 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 398527010993 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 398527010994 metal binding site [ion binding]; metal-binding site 398527010995 active site 398527010996 I-site; other site 398527010997 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 398527010998 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 398527010999 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 398527011000 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 398527011001 trimer interface [polypeptide binding]; other site 398527011002 eyelet of channel; other site 398527011003 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527011004 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527011005 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 398527011006 putative effector binding pocket; other site 398527011007 dimerization interface [polypeptide binding]; other site 398527011008 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 398527011009 B12 binding site [chemical binding]; other site 398527011010 cobalt ligand [ion binding]; other site 398527011011 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 398527011012 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 398527011013 Walker A; other site 398527011014 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 398527011015 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 398527011016 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 398527011017 FMN binding site [chemical binding]; other site 398527011018 substrate binding site [chemical binding]; other site 398527011019 putative catalytic residue [active] 398527011020 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 398527011021 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 398527011022 putative Zn2+ binding site [ion binding]; other site 398527011023 putative DNA binding site [nucleotide binding]; other site 398527011024 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 398527011025 dimerization interface [polypeptide binding]; other site 398527011026 AsnC family; Region: AsnC_trans_reg; pfam01037 398527011027 EamA-like transporter family; Region: EamA; pfam00892 398527011028 EamA-like transporter family; Region: EamA; pfam00892 398527011029 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 398527011030 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 398527011031 active site 398527011032 catalytic site [active] 398527011033 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 398527011034 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 398527011035 putative deacylase active site [active] 398527011036 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 398527011037 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 398527011038 active site 398527011039 catalytic residues [active] 398527011040 metal binding site [ion binding]; metal-binding site 398527011041 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 398527011042 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 398527011043 putative ligand binding site [chemical binding]; other site 398527011044 NAD binding site [chemical binding]; other site 398527011045 dimerization interface [polypeptide binding]; other site 398527011046 catalytic site [active] 398527011047 Serine hydrolase; Region: Ser_hydrolase; pfam06821 398527011048 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 398527011049 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 398527011050 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 398527011051 biotin synthase; Region: bioB; TIGR00433 398527011052 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 398527011053 FeS/SAM binding site; other site 398527011054 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 398527011055 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 398527011056 AAA domain; Region: AAA_26; pfam13500 398527011057 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 398527011058 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 398527011059 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 398527011060 catalytic residue [active] 398527011061 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06943 398527011062 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 398527011063 inhibitor-cofactor binding pocket; inhibition site 398527011064 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527011065 catalytic residue [active] 398527011066 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 398527011067 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 398527011068 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 398527011069 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 398527011070 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 398527011071 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 398527011072 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 398527011073 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 398527011074 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 398527011075 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 398527011076 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 398527011077 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 398527011078 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 398527011079 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 398527011080 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 398527011081 hypothetical protein; Provisional; Region: PRK01842 398527011082 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 398527011083 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 398527011084 active site 398527011085 C factor cell-cell signaling protein; Provisional; Region: PRK09009 398527011086 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 398527011087 NADP binding site [chemical binding]; other site 398527011088 homodimer interface [polypeptide binding]; other site 398527011089 active site 398527011090 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 398527011091 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 398527011092 dimer interface [polypeptide binding]; other site 398527011093 active site 398527011094 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 398527011095 active site clefts [active] 398527011096 zinc binding site [ion binding]; other site 398527011097 dimer interface [polypeptide binding]; other site 398527011098 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 398527011099 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 398527011100 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 398527011101 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 398527011102 DNA binding residues [nucleotide binding] 398527011103 putative dimer interface [polypeptide binding]; other site 398527011104 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 398527011105 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 398527011106 CHAP domain; Region: CHAP; cl17642 398527011107 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 398527011108 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 398527011109 peptide binding site [polypeptide binding]; other site 398527011110 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 398527011111 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 398527011112 intersubunit interface [polypeptide binding]; other site 398527011113 short chain dehydrogenase; Provisional; Region: PRK07024 398527011114 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 398527011115 NAD(P) binding site [chemical binding]; other site 398527011116 active site 398527011117 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 398527011118 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 398527011119 catalytic residues [active] 398527011120 hinge region; other site 398527011121 alpha helical domain; other site 398527011122 Sporulation related domain; Region: SPOR; pfam05036 398527011123 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 398527011124 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 398527011125 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 398527011126 active site 398527011127 HIGH motif; other site 398527011128 KMSK motif region; other site 398527011129 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 398527011130 tRNA binding surface [nucleotide binding]; other site 398527011131 anticodon binding site; other site 398527011132 Domain of unknown function (DUF1840); Region: DUF1840; pfam08895 398527011133 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 398527011134 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 398527011135 substrate binding pocket [chemical binding]; other site 398527011136 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 398527011137 B12 binding site [chemical binding]; other site 398527011138 cobalt ligand [ion binding]; other site 398527011139 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 398527011140 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 398527011141 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 398527011142 Protein of unknown function (DUF3567); Region: DUF3567; pfam12091 398527011143 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 398527011144 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 398527011145 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 398527011146 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 398527011147 Transcriptional regulator [Transcription]; Region: IclR; COG1414 398527011148 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 398527011149 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 398527011150 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 398527011151 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 398527011152 putative ligand binding site [chemical binding]; other site 398527011153 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 398527011154 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 398527011155 substrate binding site [chemical binding]; other site 398527011156 oxyanion hole (OAH) forming residues; other site 398527011157 trimer interface [polypeptide binding]; other site 398527011158 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 398527011159 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 398527011160 dinuclear metal binding motif [ion binding]; other site 398527011161 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 398527011162 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 398527011163 active site 398527011164 HIGH motif; other site 398527011165 nucleotide binding site [chemical binding]; other site 398527011166 pantothenate kinase; Reviewed; Region: PRK13328 398527011167 biotin--protein ligase; Provisional; Region: PRK06955 398527011168 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 398527011169 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 398527011170 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 398527011171 Permease; Region: Permease; pfam02405 398527011172 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 398527011173 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 398527011174 Walker A/P-loop; other site 398527011175 ATP binding site [chemical binding]; other site 398527011176 Q-loop/lid; other site 398527011177 ABC transporter signature motif; other site 398527011178 Walker B; other site 398527011179 D-loop; other site 398527011180 H-loop/switch region; other site 398527011181 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 398527011182 mce related protein; Region: MCE; pfam02470 398527011183 Protein of unknown function (DUF330); Region: DUF330; cl01135 398527011184 Predicted integral membrane protein [Function unknown]; Region: COG5652 398527011185 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 398527011186 dimer interface [polypeptide binding]; other site 398527011187 [2Fe-2S] cluster binding site [ion binding]; other site 398527011188 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 398527011189 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 398527011190 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 398527011191 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 398527011192 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 398527011193 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 398527011194 homodimer interface [polypeptide binding]; other site 398527011195 substrate-cofactor binding pocket; other site 398527011196 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527011197 catalytic residue [active] 398527011198 Protein of unknown function (DUF493); Region: DUF493; cl01102 398527011199 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 398527011200 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527011201 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 398527011202 dimerization interface [polypeptide binding]; other site 398527011203 substrate binding pocket [chemical binding]; other site 398527011204 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 398527011205 lipoate-protein ligase B; Provisional; Region: PRK14343 398527011206 lipoyl synthase; Provisional; Region: PRK05481 398527011207 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 398527011208 FeS/SAM binding site; other site 398527011209 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 398527011210 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 398527011211 substrate binding pocket [chemical binding]; other site 398527011212 membrane-bound complex binding site; other site 398527011213 hinge residues; other site 398527011214 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 398527011215 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 398527011216 Walker A/P-loop; other site 398527011217 ATP binding site [chemical binding]; other site 398527011218 Q-loop/lid; other site 398527011219 ABC transporter signature motif; other site 398527011220 Walker B; other site 398527011221 D-loop; other site 398527011222 H-loop/switch region; other site 398527011223 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 398527011224 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527011225 dimer interface [polypeptide binding]; other site 398527011226 conserved gate region; other site 398527011227 putative PBP binding loops; other site 398527011228 ABC-ATPase subunit interface; other site 398527011229 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 398527011230 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 398527011231 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 398527011232 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 398527011233 PhoU domain; Region: PhoU; pfam01895 398527011234 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 398527011235 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 398527011236 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 398527011237 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 398527011238 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 398527011239 putative active site [active] 398527011240 catalytic site [active] 398527011241 putative metal binding site [ion binding]; other site 398527011242 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 398527011243 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 398527011244 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 398527011245 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527011246 dimer interface [polypeptide binding]; other site 398527011247 conserved gate region; other site 398527011248 putative PBP binding loops; other site 398527011249 ABC-ATPase subunit interface; other site 398527011250 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 398527011251 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 398527011252 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527011253 dimer interface [polypeptide binding]; other site 398527011254 ABC-ATPase subunit interface; other site 398527011255 putative PBP binding loops; other site 398527011256 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 398527011257 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 398527011258 Walker A/P-loop; other site 398527011259 ATP binding site [chemical binding]; other site 398527011260 Q-loop/lid; other site 398527011261 ABC transporter signature motif; other site 398527011262 Walker B; other site 398527011263 D-loop; other site 398527011264 H-loop/switch region; other site 398527011265 TOBE domain; Region: TOBE_2; pfam08402 398527011266 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 398527011267 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 398527011268 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 398527011269 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 398527011270 dimer interface [polypeptide binding]; other site 398527011271 phosphorylation site [posttranslational modification] 398527011272 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527011273 ATP binding site [chemical binding]; other site 398527011274 Mg2+ binding site [ion binding]; other site 398527011275 G-X-G motif; other site 398527011276 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 398527011277 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527011278 active site 398527011279 phosphorylation site [posttranslational modification] 398527011280 intermolecular recognition site; other site 398527011281 dimerization interface [polypeptide binding]; other site 398527011282 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527011283 Walker A motif; other site 398527011284 ATP binding site [chemical binding]; other site 398527011285 Walker B motif; other site 398527011286 arginine finger; other site 398527011287 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 398527011288 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 398527011289 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 398527011290 catalytic residues [active] 398527011291 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 398527011292 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 398527011293 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527011294 Walker A motif; other site 398527011295 ATP binding site [chemical binding]; other site 398527011296 Walker B motif; other site 398527011297 arginine finger; other site 398527011298 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 398527011299 Membrane fusogenic activity; Region: BMFP; pfam04380 398527011300 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 398527011301 Nitrogen regulatory protein P-II; Region: P-II; smart00938 398527011302 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 398527011303 glutamate--cysteine ligase, T. ferrooxidans family; Region: gshA_ferroox; TIGR02049 398527011304 Glutamate-cysteine ligase; Region: GshA; pfam08886 398527011305 glutathione synthetase; Provisional; Region: PRK05246 398527011306 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 398527011307 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 398527011308 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 398527011309 active pocket/dimerization site; other site 398527011310 active site 398527011311 phosphorylation site [posttranslational modification] 398527011312 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 398527011313 dimerization domain swap beta strand [polypeptide binding]; other site 398527011314 regulatory protein interface [polypeptide binding]; other site 398527011315 active site 398527011316 regulatory phosphorylation site [posttranslational modification]; other site 398527011317 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 398527011318 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 398527011319 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 398527011320 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 398527011321 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 398527011322 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 398527011323 ATP binding site [chemical binding]; other site 398527011324 substrate interface [chemical binding]; other site 398527011325 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 398527011326 C-terminal peptidase (prc); Region: prc; TIGR00225 398527011327 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 398527011328 protein binding site [polypeptide binding]; other site 398527011329 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 398527011330 Catalytic dyad [active] 398527011331 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 398527011332 catalytic core [active] 398527011333 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 398527011334 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 398527011335 active site residue [active] 398527011336 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 398527011337 GSH binding site [chemical binding]; other site 398527011338 catalytic residues [active] 398527011339 preprotein translocase subunit SecB; Validated; Region: PRK05751 398527011340 SecA binding site; other site 398527011341 Preprotein binding site; other site 398527011342 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 398527011343 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 398527011344 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 398527011345 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 398527011346 putative ADP-ribose binding site [chemical binding]; other site 398527011347 putative active site [active] 398527011348 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 398527011349 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 398527011350 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 398527011351 active site 398527011352 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 398527011353 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 398527011354 S-adenosylmethionine binding site [chemical binding]; other site 398527011355 Integral membrane protein (DUF2244); Region: DUF2244; pfam10003 398527011356 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 398527011357 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 398527011358 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 398527011359 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 398527011360 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 398527011361 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 398527011362 ligand binding site [chemical binding]; other site 398527011363 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 398527011364 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 398527011365 Subunit I/III interface [polypeptide binding]; other site 398527011366 D-pathway; other site 398527011367 Subunit I/VIIc interface [polypeptide binding]; other site 398527011368 Subunit I/IV interface [polypeptide binding]; other site 398527011369 Subunit I/II interface [polypeptide binding]; other site 398527011370 Low-spin heme (heme a) binding site [chemical binding]; other site 398527011371 Subunit I/VIIa interface [polypeptide binding]; other site 398527011372 Subunit I/VIa interface [polypeptide binding]; other site 398527011373 Dimer interface; other site 398527011374 Putative water exit pathway; other site 398527011375 Binuclear center (heme a3/CuB) [ion binding]; other site 398527011376 K-pathway; other site 398527011377 Subunit I/Vb interface [polypeptide binding]; other site 398527011378 Putative proton exit pathway; other site 398527011379 Subunit I/VIb interface; other site 398527011380 Subunit I/VIc interface [polypeptide binding]; other site 398527011381 Electron transfer pathway; other site 398527011382 Subunit I/VIIIb interface [polypeptide binding]; other site 398527011383 Subunit I/VIIb interface [polypeptide binding]; other site 398527011384 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 398527011385 Protein of unknown function (DUF2970); Region: DUF2970; pfam11174 398527011386 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 398527011387 Subunit III/VIIa interface [polypeptide binding]; other site 398527011388 Phospholipid binding site [chemical binding]; other site 398527011389 Subunit I/III interface [polypeptide binding]; other site 398527011390 Subunit III/VIb interface [polypeptide binding]; other site 398527011391 Subunit III/VIa interface; other site 398527011392 Subunit III/Vb interface [polypeptide binding]; other site 398527011393 Protein of unknown function (DUF2909); Region: DUF2909; pfam11137 398527011394 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 398527011395 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 398527011396 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 398527011397 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 398527011398 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 398527011399 UbiA prenyltransferase family; Region: UbiA; pfam01040 398527011400 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 398527011401 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 398527011402 Cu(I) binding site [ion binding]; other site 398527011403 YCII-related domain; Region: YCII; cl00999 398527011404 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 398527011405 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 398527011406 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 398527011407 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 398527011408 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 398527011409 dimer interface [polypeptide binding]; other site 398527011410 putative CheW interface [polypeptide binding]; other site 398527011411 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 398527011412 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 398527011413 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 398527011414 MarR family; Region: MarR; pfam01047 398527011415 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 398527011416 Coenzyme A binding pocket [chemical binding]; other site 398527011417 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 398527011418 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527011419 DNA-binding site [nucleotide binding]; DNA binding site 398527011420 UTRA domain; Region: UTRA; pfam07702 398527011421 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 398527011422 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 398527011423 active site 398527011424 dimer interface [polypeptide binding]; other site 398527011425 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 398527011426 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 398527011427 dimer interface [polypeptide binding]; other site 398527011428 active site 398527011429 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 398527011430 dimer interface [polypeptide binding]; other site 398527011431 active site 398527011432 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 398527011433 HPr interaction site; other site 398527011434 glycerol kinase (GK) interaction site [polypeptide binding]; other site 398527011435 active site 398527011436 phosphorylation site [posttranslational modification] 398527011437 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 398527011438 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 398527011439 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 398527011440 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 398527011441 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 398527011442 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 398527011443 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 398527011444 active site turn [active] 398527011445 phosphorylation site [posttranslational modification] 398527011446 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 398527011447 active site turn [active] 398527011448 phosphorylation site [posttranslational modification] 398527011449 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 398527011450 Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173 398527011451 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 398527011452 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 398527011453 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 398527011454 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 398527011455 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 398527011456 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 398527011457 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 398527011458 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 398527011459 DNA binding residues [nucleotide binding] 398527011460 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 398527011461 SnoaL-like domain; Region: SnoaL_2; pfam12680 398527011462 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 398527011463 active site 398527011464 catalytic residues [active] 398527011465 metal binding site [ion binding]; metal-binding site 398527011466 glycosyl transferase family protein; Provisional; Region: PRK08136 398527011467 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 398527011468 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 398527011469 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 398527011470 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 398527011471 maleylacetoacetate isomerase; Region: maiA; TIGR01262 398527011472 C-terminal domain interface [polypeptide binding]; other site 398527011473 GSH binding site (G-site) [chemical binding]; other site 398527011474 putative dimer interface [polypeptide binding]; other site 398527011475 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 398527011476 dimer interface [polypeptide binding]; other site 398527011477 N-terminal domain interface [polypeptide binding]; other site 398527011478 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 398527011479 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 398527011480 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 398527011481 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 398527011482 P loop; other site 398527011483 GTP binding site [chemical binding]; other site 398527011484 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 398527011485 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 398527011486 S-adenosylmethionine binding site [chemical binding]; other site 398527011487 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 398527011488 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 398527011489 active site 398527011490 (T/H)XGH motif; other site 398527011491 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 398527011492 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 398527011493 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 398527011494 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527011495 homodimer interface [polypeptide binding]; other site 398527011496 catalytic residue [active] 398527011497 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 398527011498 putative active site [active] 398527011499 catalytic residue [active] 398527011500 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 398527011501 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 398527011502 5S rRNA interface [nucleotide binding]; other site 398527011503 CTC domain interface [polypeptide binding]; other site 398527011504 L16 interface [polypeptide binding]; other site 398527011505 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 398527011506 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 398527011507 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 398527011508 active site 398527011509 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 398527011510 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 398527011511 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 398527011512 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 398527011513 TPR motif; other site 398527011514 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 398527011515 binding surface 398527011516 TPR repeat; Region: TPR_11; pfam13414 398527011517 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 398527011518 TPR motif; other site 398527011519 binding surface 398527011520 TPR repeat; Region: TPR_11; pfam13414 398527011521 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 398527011522 binding surface 398527011523 TPR motif; other site 398527011524 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 398527011525 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 398527011526 DNA binding site [nucleotide binding] 398527011527 catalytic residue [active] 398527011528 H2TH interface [polypeptide binding]; other site 398527011529 putative catalytic residues [active] 398527011530 turnover-facilitating residue; other site 398527011531 intercalation triad [nucleotide binding]; other site 398527011532 8OG recognition residue [nucleotide binding]; other site 398527011533 putative reading head residues; other site 398527011534 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 398527011535 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 398527011536 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 398527011537 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 398527011538 minor groove reading motif; other site 398527011539 helix-hairpin-helix signature motif; other site 398527011540 substrate binding pocket [chemical binding]; other site 398527011541 active site 398527011542 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 398527011543 DNA binding and oxoG recognition site [nucleotide binding] 398527011544 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 398527011545 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 398527011546 AAA domain; Region: AAA_18; pfam13238 398527011547 HPr kinase/phosphorylase; Provisional; Region: PRK05428 398527011548 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 398527011549 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 398527011550 Hpr binding site; other site 398527011551 active site 398527011552 homohexamer subunit interaction site [polypeptide binding]; other site 398527011553 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 398527011554 active site 398527011555 phosphorylation site [posttranslational modification] 398527011556 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 398527011557 30S subunit binding site; other site 398527011558 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 398527011559 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 398527011560 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 398527011561 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 398527011562 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 398527011563 Walker A/P-loop; other site 398527011564 ATP binding site [chemical binding]; other site 398527011565 Q-loop/lid; other site 398527011566 ABC transporter signature motif; other site 398527011567 Walker B; other site 398527011568 D-loop; other site 398527011569 H-loop/switch region; other site 398527011570 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 398527011571 OstA-like protein; Region: OstA; pfam03968 398527011572 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117 398527011573 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 398527011574 Low specificity phosphatase (HAD superfamily) [General function prediction only]; Region: COG1778 398527011575 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 398527011576 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 398527011577 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 398527011578 putative active site [active] 398527011579 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 398527011580 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 398527011581 putative cation:proton antiport protein; Provisional; Region: PRK10669 398527011582 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 398527011583 TrkA-N domain; Region: TrkA_N; pfam02254 398527011584 TrkA-C domain; Region: TrkA_C; pfam02080 398527011585 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 398527011586 active site 398527011587 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 398527011588 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belong to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_hydrolase_3; cd03676 398527011589 nudix motif; other site 398527011590 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 398527011591 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 398527011592 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 398527011593 putative active site [active] 398527011594 putative substrate binding site [chemical binding]; other site 398527011595 putative cosubstrate binding site; other site 398527011596 catalytic site [active] 398527011597 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 398527011598 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 398527011599 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 398527011600 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 398527011601 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 398527011602 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 398527011603 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 398527011604 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 398527011605 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527011606 Major Facilitator Superfamily; Region: MFS_1; pfam07690 398527011607 putative substrate translocation pore; other site 398527011608 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 398527011609 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 398527011610 dimer interface [polypeptide binding]; other site 398527011611 ssDNA binding site [nucleotide binding]; other site 398527011612 tetramer (dimer of dimers) interface [polypeptide binding]; other site 398527011613 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 398527011614 putative active site [active] 398527011615 putative catalytic site [active] 398527011616 benzoate transport; Region: 2A0115; TIGR00895 398527011617 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527011618 putative substrate translocation pore; other site 398527011619 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527011620 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 398527011621 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 398527011622 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 398527011623 active site 398527011624 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 398527011625 CoA-transferase family III; Region: CoA_transf_3; pfam02515 398527011626 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 398527011627 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527011628 DNA-binding site [nucleotide binding]; DNA binding site 398527011629 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 398527011630 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 398527011631 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 398527011632 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 398527011633 Tar ligand binding domain homologue; Region: TarH; pfam02203 398527011634 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 398527011635 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 398527011636 dimerization interface [polypeptide binding]; other site 398527011637 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 398527011638 dimer interface [polypeptide binding]; other site 398527011639 putative CheW interface [polypeptide binding]; other site 398527011640 Cytochrome c; Region: Cytochrom_C; cl11414 398527011641 Cytochrome c; Region: Cytochrom_C; pfam00034 398527011642 ba3-like heme-copper oxidase subunit I. The ba3 family of heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and some archaea which catalyze the reduction of O2 and simultaneously pump protons across the...; Region: ba3-like_Oxidase_I; cd01660 398527011643 Low-spin heme binding site [chemical binding]; other site 398527011644 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 398527011645 Subunit I/II interface [polypeptide binding]; other site 398527011646 Putative Q-pathway; other site 398527011647 Putative D-pathway homolog; other site 398527011648 Putative alternate electron transfer pathway; other site 398527011649 Putative water exit pathway; other site 398527011650 Binuclear center (active site) [active] 398527011651 Putative K-pathway homolog; other site 398527011652 Putative proton exit pathway; other site 398527011653 Subunit I/IIa interface [polypeptide binding]; other site 398527011654 Electron transfer pathway; other site 398527011655 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 398527011656 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 398527011657 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 398527011658 Cytochrome c; Region: Cytochrom_C; pfam00034 398527011659 Cytochrome c; Region: Cytochrom_C; cl11414 398527011660 Cytochrome c; Region: Cytochrom_C; cl11414 398527011661 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527011662 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527011663 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 398527011664 dimerization interface [polypeptide binding]; other site 398527011665 Major Facilitator Superfamily; Region: MFS_1; pfam07690 398527011666 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527011667 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 398527011668 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527011669 active site 398527011670 phosphorylation site [posttranslational modification] 398527011671 intermolecular recognition site; other site 398527011672 dimerization interface [polypeptide binding]; other site 398527011673 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 398527011674 DNA binding residues [nucleotide binding] 398527011675 dimerization interface [polypeptide binding]; other site 398527011676 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 398527011677 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527011678 active site 398527011679 phosphorylation site [posttranslational modification] 398527011680 intermolecular recognition site; other site 398527011681 dimerization interface [polypeptide binding]; other site 398527011682 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 398527011683 DNA binding residues [nucleotide binding] 398527011684 dimerization interface [polypeptide binding]; other site 398527011685 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 398527011686 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527011687 active site 398527011688 phosphorylation site [posttranslational modification] 398527011689 intermolecular recognition site; other site 398527011690 dimerization interface [polypeptide binding]; other site 398527011691 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 398527011692 DNA binding residues [nucleotide binding] 398527011693 dimerization interface [polypeptide binding]; other site 398527011694 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 398527011695 amphipathic channel; other site 398527011696 Asn-Pro-Ala signature motifs; other site 398527011697 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 398527011698 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 398527011699 substrate binding pocket [chemical binding]; other site 398527011700 membrane-bound complex binding site; other site 398527011701 hinge residues; other site 398527011702 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 398527011703 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 398527011704 substrate binding pocket [chemical binding]; other site 398527011705 membrane-bound complex binding site; other site 398527011706 hinge residues; other site 398527011707 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 398527011708 PAS domain; Region: PAS_9; pfam13426 398527011709 putative active site [active] 398527011710 heme pocket [chemical binding]; other site 398527011711 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 398527011712 dimer interface [polypeptide binding]; other site 398527011713 phosphorylation site [posttranslational modification] 398527011714 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527011715 ATP binding site [chemical binding]; other site 398527011716 Mg2+ binding site [ion binding]; other site 398527011717 G-X-G motif; other site 398527011718 Response regulator receiver domain; Region: Response_reg; pfam00072 398527011719 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527011720 active site 398527011721 phosphorylation site [posttranslational modification] 398527011722 intermolecular recognition site; other site 398527011723 dimerization interface [polypeptide binding]; other site 398527011724 CHRD domain; Region: CHRD; pfam07452 398527011725 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 398527011726 EcsC protein family; Region: EcsC; pfam12787 398527011727 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 398527011728 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527011729 putative substrate translocation pore; other site 398527011730 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527011731 Transcriptional regulators [Transcription]; Region: MarR; COG1846 398527011732 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 398527011733 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 398527011734 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 398527011735 dimer interface [polypeptide binding]; other site 398527011736 active site 398527011737 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 398527011738 substrate binding site [chemical binding]; other site 398527011739 catalytic residue [active] 398527011740 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 398527011741 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 398527011742 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 398527011743 putative active site [active] 398527011744 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 398527011745 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 398527011746 active site 398527011747 putative substrate binding pocket [chemical binding]; other site 398527011748 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 398527011749 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 398527011750 homotrimer interaction site [polypeptide binding]; other site 398527011751 putative active site [active] 398527011752 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 398527011753 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 398527011754 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 398527011755 5'-nucleotidase; Region: 5-nucleotidase; pfam06189 398527011756 threonine dehydratase; Reviewed; Region: PRK09224 398527011757 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 398527011758 tetramer interface [polypeptide binding]; other site 398527011759 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527011760 catalytic residue [active] 398527011761 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 398527011762 putative Ile/Val binding site [chemical binding]; other site 398527011763 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 398527011764 putative Ile/Val binding site [chemical binding]; other site 398527011765 Protein of unknown function (DUF3683); Region: DUF3683; pfam12447 398527011766 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 398527011767 FAD binding domain; Region: FAD_binding_4; pfam01565 398527011768 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 398527011769 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 398527011770 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 398527011771 Cysteine-rich domain; Region: CCG; pfam02754 398527011772 Domain of unknown function (DUF3400); Region: DUF3400; pfam11880 398527011773 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 398527011774 nucleotide binding site/active site [active] 398527011775 HIT family signature motif; other site 398527011776 catalytic residue [active] 398527011777 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536 398527011778 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 398527011779 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 398527011780 S-adenosylmethionine binding site [chemical binding]; other site 398527011781 Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978 398527011782 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 398527011783 SCP-2 sterol transfer family; Region: SCP2; pfam02036 398527011784 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 398527011785 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 398527011786 Thiopurine S-methyltransferase (TPMT); Region: TPMT; pfam05724 398527011787 Methyltransferase domain; Region: Methyltransf_12; pfam08242 398527011788 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 398527011789 Uncharacterized conserved protein [Function unknown]; Region: COG2928 398527011790 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 398527011791 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 398527011792 dimer interface [polypeptide binding]; other site 398527011793 anticodon binding site; other site 398527011794 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 398527011795 homodimer interface [polypeptide binding]; other site 398527011796 motif 1; other site 398527011797 active site 398527011798 motif 2; other site 398527011799 GAD domain; Region: GAD; pfam02938 398527011800 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 398527011801 motif 3; other site 398527011802 dihydroneopterin triphosphate pyrophosphatase; Provisional; Region: nudB; PRK09438 398527011803 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 398527011804 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 398527011805 putative active site [active] 398527011806 catalytic site [active] 398527011807 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 398527011808 putative active site [active] 398527011809 catalytic site [active] 398527011810 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 398527011811 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 398527011812 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 398527011813 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 398527011814 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 398527011815 FAD binding site [chemical binding]; other site 398527011816 substrate binding site [chemical binding]; other site 398527011817 catalytic residues [active] 398527011818 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 398527011819 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 398527011820 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 398527011821 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 398527011822 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 398527011823 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 398527011824 substrate binding site [chemical binding]; other site 398527011825 oxyanion hole (OAH) forming residues; other site 398527011826 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 398527011827 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 398527011828 dimer interface [polypeptide binding]; other site 398527011829 active site 398527011830 enoyl-CoA hydratase; Provisional; Region: PRK06688 398527011831 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 398527011832 substrate binding site [chemical binding]; other site 398527011833 oxyanion hole (OAH) forming residues; other site 398527011834 trimer interface [polypeptide binding]; other site 398527011835 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 398527011836 Conserved nitrate reductase-associated protein (Nitr_red_assoc); Region: Nitr_red_assoc; pfam09655 398527011837 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 398527011838 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 398527011839 putative active site [active] 398527011840 heme pocket [chemical binding]; other site 398527011841 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 398527011842 putative active site [active] 398527011843 heme pocket [chemical binding]; other site 398527011844 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 398527011845 metal binding site [ion binding]; metal-binding site 398527011846 active site 398527011847 I-site; other site 398527011848 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 398527011849 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 398527011850 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 398527011851 C-terminal domain interface [polypeptide binding]; other site 398527011852 GSH binding site (G-site) [chemical binding]; other site 398527011853 dimer interface [polypeptide binding]; other site 398527011854 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 398527011855 substrate binding pocket (H-site) [chemical binding]; other site 398527011856 N-terminal domain interface [polypeptide binding]; other site 398527011857 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 398527011858 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527011859 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 398527011860 dimerization interface [polypeptide binding]; other site 398527011861 substrate binding pocket [chemical binding]; other site 398527011862 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 398527011863 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 398527011864 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 398527011865 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 398527011866 Walker A/P-loop; other site 398527011867 ATP binding site [chemical binding]; other site 398527011868 Q-loop/lid; other site 398527011869 ABC transporter signature motif; other site 398527011870 Walker B; other site 398527011871 D-loop; other site 398527011872 H-loop/switch region; other site 398527011873 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 398527011874 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 398527011875 Substrate binding site; other site 398527011876 metal-binding site 398527011877 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 398527011878 Phosphotransferase enzyme family; Region: APH; pfam01636 398527011879 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 398527011880 Organic solvent tolerance protein; Region: OstA_C; pfam04453 398527011881 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 398527011882 SurA N-terminal domain; Region: SurA_N; pfam09312 398527011883 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 398527011884 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 398527011885 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK01909 398527011886 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 398527011887 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 398527011888 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 398527011889 S-adenosylmethionine binding site [chemical binding]; other site 398527011890 EamA-like transporter family; Region: EamA; pfam00892 398527011891 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 398527011892 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 398527011893 trimer interface [polypeptide binding]; other site 398527011894 eyelet of channel; other site 398527011895 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 398527011896 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 398527011897 dimer interface [polypeptide binding]; other site 398527011898 active site 398527011899 metal binding site [ion binding]; metal-binding site 398527011900 glutathione binding site [chemical binding]; other site 398527011901 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 398527011902 Protein of unknown function DUF45; Region: DUF45; pfam01863 398527011903 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 398527011904 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 398527011905 putative acyl-acceptor binding pocket; other site 398527011906 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 398527011907 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 398527011908 active site 398527011909 motif I; other site 398527011910 motif II; other site 398527011911 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 398527011912 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 398527011913 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 398527011914 dimer interface [polypeptide binding]; other site 398527011915 motif 1; other site 398527011916 active site 398527011917 motif 2; other site 398527011918 motif 3; other site 398527011919 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 398527011920 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 398527011921 active site 398527011922 FMN binding site [chemical binding]; other site 398527011923 substrate binding site [chemical binding]; other site 398527011924 3Fe-4S cluster binding site [ion binding]; other site 398527011925 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 398527011926 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 398527011927 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 398527011928 nudix motif; other site 398527011929 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 398527011930 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 398527011931 ligand binding site [chemical binding]; other site 398527011932 homodimer interface [polypeptide binding]; other site 398527011933 NAD(P) binding site [chemical binding]; other site 398527011934 trimer interface B [polypeptide binding]; other site 398527011935 trimer interface A [polypeptide binding]; other site 398527011936 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 398527011937 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 398527011938 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 398527011939 Predicted transcriptional regulator [Transcription]; Region: COG2378 398527011940 HTH domain; Region: HTH_11; pfam08279 398527011941 WYL domain; Region: WYL; pfam13280 398527011942 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 398527011943 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 398527011944 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 398527011945 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 398527011946 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 398527011947 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 398527011948 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 398527011949 generic binding surface II; other site 398527011950 ssDNA binding site; other site 398527011951 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 398527011952 ATP binding site [chemical binding]; other site 398527011953 putative Mg++ binding site [ion binding]; other site 398527011954 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 398527011955 nucleotide binding region [chemical binding]; other site 398527011956 ATP-binding site [chemical binding]; other site 398527011957 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 398527011958 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 398527011959 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 398527011960 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 398527011961 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 398527011962 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 398527011963 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 398527011964 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 398527011965 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 398527011966 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 398527011967 Protein export membrane protein; Region: SecD_SecF; pfam02355 398527011968 citrate-proton symporter; Provisional; Region: PRK15075 398527011969 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527011970 putative substrate translocation pore; other site 398527011971 Uncharacterized conserved protein [Function unknown]; Region: COG2353 398527011972 YceI-like domain; Region: YceI; smart00867 398527011973 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 398527011974 Paraquat-inducible protein A; Region: PqiA; pfam04403 398527011975 Paraquat-inducible protein A; Region: PqiA; pfam04403 398527011976 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 398527011977 mce related protein; Region: MCE; pfam02470 398527011978 mce related protein; Region: MCE; pfam02470 398527011979 mce related protein; Region: MCE; pfam02470 398527011980 Protein of unknown function (DUF330); Region: DUF330; pfam03886 398527011981 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527011982 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527011983 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 398527011984 dimerization interface [polypeptide binding]; other site 398527011985 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 398527011986 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 398527011987 tetramer interface [polypeptide binding]; other site 398527011988 heme binding pocket [chemical binding]; other site 398527011989 NADPH binding site [chemical binding]; other site 398527011990 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 398527011991 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 398527011992 dimerization interface [polypeptide binding]; other site 398527011993 DPS ferroxidase diiron center [ion binding]; other site 398527011994 ion pore; other site 398527011995 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 398527011996 UbiA prenyltransferase family; Region: UbiA; pfam01040 398527011997 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 398527011998 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 398527011999 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 398527012000 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 398527012001 catalytic residue [active] 398527012002 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 398527012003 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 398527012004 Cysteine-rich domain; Region: CCG; pfam02754 398527012005 Cysteine-rich domain; Region: CCG; pfam02754 398527012006 FAD binding domain; Region: FAD_binding_4; pfam01565 398527012007 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 398527012008 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 398527012009 FAD binding domain; Region: FAD_binding_4; pfam01565 398527012010 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 398527012011 FAD binding domain; Region: FAD_binding_4; pfam01565 398527012012 ATP:cob(I)alamin adenosyltransferase; Region: PduO_Nterm; TIGR00636 398527012013 Uncharacterized conserved small protein [Function unknown]; Region: COG5606 398527012014 non-specific DNA binding site [nucleotide binding]; other site 398527012015 salt bridge; other site 398527012016 sequence-specific DNA binding site [nucleotide binding]; other site 398527012017 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 398527012018 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 398527012019 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 398527012020 protease TldD; Provisional; Region: tldD; PRK10735 398527012021 nitrilase; Region: PLN02798 398527012022 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 398527012023 putative active site [active] 398527012024 catalytic triad [active] 398527012025 dimer interface [polypeptide binding]; other site 398527012026 TIGR02099 family protein; Region: TIGR02099 398527012027 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 398527012028 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 398527012029 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 398527012030 metal binding triad; other site 398527012031 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 398527012032 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 398527012033 metal binding triad; other site 398527012034 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 398527012035 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 398527012036 Walker A/P-loop; other site 398527012037 ATP binding site [chemical binding]; other site 398527012038 Q-loop/lid; other site 398527012039 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 398527012040 ABC transporter signature motif; other site 398527012041 Walker B; other site 398527012042 D-loop; other site 398527012043 H-loop/switch region; other site 398527012044 NAD(+)/NADH kinase family protein; Provisional; Region: ppnK; PRK02155 398527012045 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 398527012046 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 398527012047 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 398527012048 ferrochelatase; Reviewed; Region: hemH; PRK00035 398527012049 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 398527012050 C-terminal domain interface [polypeptide binding]; other site 398527012051 active site 398527012052 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 398527012053 active site 398527012054 N-terminal domain interface [polypeptide binding]; other site 398527012055 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 398527012056 RNA binding surface [nucleotide binding]; other site 398527012057 GrpE; Region: GrpE; pfam01025 398527012058 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 398527012059 dimer interface [polypeptide binding]; other site 398527012060 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 398527012061 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 398527012062 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 398527012063 nucleotide binding site [chemical binding]; other site 398527012064 chaperone protein DnaJ; Provisional; Region: PRK10767 398527012065 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 398527012066 HSP70 interaction site [polypeptide binding]; other site 398527012067 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 398527012068 Zn binding sites [ion binding]; other site 398527012069 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 398527012070 dimer interface [polypeptide binding]; other site 398527012071 chorismate binding enzyme; Region: Chorismate_bind; cl10555 398527012072 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 398527012073 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 398527012074 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 398527012075 substrate-cofactor binding pocket; other site 398527012076 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527012077 catalytic residue [active] 398527012078 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 398527012079 oligomerization interface [polypeptide binding]; other site 398527012080 active site 398527012081 metal binding site [ion binding]; metal-binding site 398527012082 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 398527012083 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 398527012084 Substrate-binding site [chemical binding]; other site 398527012085 Substrate specificity [chemical binding]; other site 398527012086 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 398527012087 catalytic center binding site [active] 398527012088 ATP binding site [chemical binding]; other site 398527012089 poly(A) polymerase; Region: pcnB; TIGR01942 398527012090 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 398527012091 active site 398527012092 NTP binding site [chemical binding]; other site 398527012093 metal binding triad [ion binding]; metal-binding site 398527012094 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 398527012095 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 398527012096 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 398527012097 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 398527012098 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 398527012099 DnaA regulatory inactivator Hda; Validated; Region: PRK08903 398527012100 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 398527012101 Domain of unknown function DUF20; Region: UPF0118; pfam01594 398527012102 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 398527012103 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 398527012104 dimerization interface [polypeptide binding]; other site 398527012105 putative ATP binding site [chemical binding]; other site 398527012106 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 398527012107 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 398527012108 DNA mismatch repair protein MutL; Region: mutl; TIGR00585 398527012109 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527012110 ATP binding site [chemical binding]; other site 398527012111 Mg2+ binding site [ion binding]; other site 398527012112 G-X-G motif; other site 398527012113 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 398527012114 ATP binding site [chemical binding]; other site 398527012115 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 398527012116 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 398527012117 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 398527012118 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 398527012119 Mechanosensitive ion channel; Region: MS_channel; pfam00924 398527012120 Peptidase family C69; Region: Peptidase_C69; cl17793 398527012121 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 398527012122 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 398527012123 trimer interface [polypeptide binding]; other site 398527012124 eyelet of channel; other site 398527012125 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 398527012126 Tetratricopeptide repeat; Region: TPR_6; pfam13174 398527012127 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 398527012128 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 398527012129 ligand binding site [chemical binding]; other site 398527012130 translocation protein TolB; Provisional; Region: tolB; PRK02889 398527012131 TolB amino-terminal domain; Region: TolB_N; pfam04052 398527012132 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 398527012133 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 398527012134 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 398527012135 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 398527012136 TolA protein; Region: tolA_full; TIGR02794 398527012137 TolA protein; Region: tolA_full; TIGR02794 398527012138 TonB C terminal; Region: TonB_2; pfam13103 398527012139 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 398527012140 TolR protein; Region: tolR; TIGR02801 398527012141 TolQ protein; Region: tolQ; TIGR02796 398527012142 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 398527012143 active site 398527012144 malonic semialdehyde reductase; Provisional; Region: PRK10538 398527012145 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 398527012146 putative NAD(P) binding site [chemical binding]; other site 398527012147 homodimer interface [polypeptide binding]; other site 398527012148 homotetramer interface [polypeptide binding]; other site 398527012149 active site 398527012150 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 398527012151 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 398527012152 dimer interface [polypeptide binding]; other site 398527012153 active site 398527012154 glycine-pyridoxal phosphate binding site [chemical binding]; other site 398527012155 folate binding site [chemical binding]; other site 398527012156 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 398527012157 ATP cone domain; Region: ATP-cone; pfam03477 398527012158 Type II transport protein GspH; Region: GspH; pfam12019 398527012159 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 398527012160 PilX N-terminal; Region: PilX_N; pfam14341 398527012161 Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968 398527012162 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 398527012163 Predicted membrane protein [Function unknown]; Region: COG5393 398527012164 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 398527012165 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 398527012166 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 398527012167 dimer interface [polypeptide binding]; other site 398527012168 decamer (pentamer of dimers) interface [polypeptide binding]; other site 398527012169 catalytic triad [active] 398527012170 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 398527012171 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 398527012172 FAD binding site [chemical binding]; other site 398527012173 substrate binding pocket [chemical binding]; other site 398527012174 catalytic base [active] 398527012175 Transcriptional regulator [Transcription]; Region: IclR; COG1414 398527012176 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 398527012177 Bacterial transcriptional regulator; Region: IclR; pfam01614 398527012178 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 398527012179 benzoate transport; Region: 2A0115; TIGR00895 398527012180 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527012181 putative substrate translocation pore; other site 398527012182 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527012183 putative substrate translocation pore; other site 398527012184 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 398527012185 fumarylacetoacetase; Region: PLN02856 398527012186 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 398527012187 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 398527012188 Transposase, Mutator family; Region: Transposase_mut; pfam00872 398527012189 MULE transposase domain; Region: MULE; pfam10551 398527012190 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527012191 Major Facilitator Superfamily; Region: MFS_1; pfam07690 398527012192 putative substrate translocation pore; other site 398527012193 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 398527012194 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527012195 putative substrate translocation pore; other site 398527012196 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 398527012197 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 398527012198 substrate binding site [chemical binding]; other site 398527012199 oxyanion hole (OAH) forming residues; other site 398527012200 trimer interface [polypeptide binding]; other site 398527012201 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 398527012202 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 398527012203 putative ligand binding site [chemical binding]; other site 398527012204 putative NAD binding site [chemical binding]; other site 398527012205 catalytic site [active] 398527012206 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 398527012207 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 398527012208 TrkA-C domain; Region: TrkA_C; pfam02080 398527012209 TrkA-C domain; Region: TrkA_C; pfam02080 398527012210 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 398527012211 aspartate-alanine antiporter; Region: Asp_Ala_antiprt; TIGR03802 398527012212 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 398527012213 TrkA-C domain; Region: TrkA_C; pfam02080 398527012214 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 398527012215 aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801 398527012216 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 398527012217 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527012218 homodimer interface [polypeptide binding]; other site 398527012219 catalytic residue [active] 398527012220 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 398527012221 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 398527012222 catalytic residue [active] 398527012223 major facilitator superfamily transporter; Provisional; Region: PRK05122 398527012224 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 398527012225 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 398527012226 catalytic loop [active] 398527012227 iron binding site [ion binding]; other site 398527012228 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 398527012229 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 398527012230 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 398527012231 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 398527012232 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 398527012233 XdhC Rossmann domain; Region: XdhC_C; pfam13478 398527012234 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527012235 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527012236 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_4; cd08463 398527012237 putative substrate binding pocket [chemical binding]; other site 398527012238 putative dimerization interface [polypeptide binding]; other site 398527012239 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 398527012240 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 398527012241 putative catalytic residue [active] 398527012242 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 398527012243 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 398527012244 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 398527012245 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 398527012246 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527012247 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527012248 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 398527012249 putative dimerization interface [polypeptide binding]; other site 398527012250 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 398527012251 active site 398527012252 catalytic residues [active] 398527012253 metal binding site [ion binding]; metal-binding site 398527012254 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 398527012255 CoA-transferase family III; Region: CoA_transf_3; pfam02515 398527012256 benzoate transport; Region: 2A0115; TIGR00895 398527012257 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527012258 putative substrate translocation pore; other site 398527012259 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527012260 putative substrate translocation pore; other site 398527012261 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 398527012262 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 398527012263 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 398527012264 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 398527012265 active site 398527012266 GDP-Mannose binding site [chemical binding]; other site 398527012267 dimer interface [polypeptide binding]; other site 398527012268 modified nudix motif 398527012269 metal binding site [ion binding]; metal-binding site 398527012270 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 398527012271 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 398527012272 conserved cys residue [active] 398527012273 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 398527012274 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 398527012275 Substrate binding site; other site 398527012276 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 398527012277 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 398527012278 Bacterial sugar transferase; Region: Bac_transf; pfam02397 398527012279 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 398527012280 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 398527012281 SLBB domain; Region: SLBB; pfam10531 398527012282 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 398527012283 tyrosine kinase; Provisional; Region: PRK11519 398527012284 Chain length determinant protein; Region: Wzz; pfam02706 398527012285 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 398527012286 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 398527012287 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 398527012288 NADP-binding site; other site 398527012289 homotetramer interface [polypeptide binding]; other site 398527012290 substrate binding site [chemical binding]; other site 398527012291 homodimer interface [polypeptide binding]; other site 398527012292 active site 398527012293 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 398527012294 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 398527012295 NADP binding site [chemical binding]; other site 398527012296 active site 398527012297 putative substrate binding site [chemical binding]; other site 398527012298 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 398527012299 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 398527012300 putative glycosyl transferase; Provisional; Region: PRK10307 398527012301 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 398527012302 putative acyl transferase; Provisional; Region: PRK10502 398527012303 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 398527012304 putative trimer interface [polypeptide binding]; other site 398527012305 putative active site [active] 398527012306 putative substrate binding site [chemical binding]; other site 398527012307 putative CoA binding site [chemical binding]; other site 398527012308 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 398527012309 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 398527012310 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 398527012311 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 398527012312 putative ADP-binding pocket [chemical binding]; other site 398527012313 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 398527012314 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 398527012315 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 398527012316 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 398527012317 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 398527012318 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 398527012319 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 398527012320 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 398527012321 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 398527012322 Cl- selectivity filter; other site 398527012323 Cl- binding residues [ion binding]; other site 398527012324 pore gating glutamate residue; other site 398527012325 FOG: CBS domain [General function prediction only]; Region: COG0517 398527012326 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 398527012327 MarR family; Region: MarR_2; pfam12802 398527012328 MarR family; Region: MarR_2; cl17246 398527012329 CBS-domain-containing membrane protein [Signal transduction mechanisms]; Region: COG3448 398527012330 HPP family; Region: HPP; pfam04982 398527012331 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 398527012332 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the HPP motif domain. These proteins are integral membrane proteins with four transmembrane spanning helices. The function of these proteins is...; Region: CBS_pair_HPP_assoc; cd04600 398527012333 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 398527012334 S-adenosylmethionine binding site [chemical binding]; other site 398527012335 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527012336 Helix-turn-helix domain; Region: HTH_18; pfam12833 398527012337 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527012338 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 398527012339 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 398527012340 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 398527012341 Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790 398527012342 tyrosine kinase; Provisional; Region: PRK11519 398527012343 Chain length determinant protein; Region: Wzz; pfam02706 398527012344 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 398527012345 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 398527012346 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 398527012347 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 398527012348 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 398527012349 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 398527012350 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 398527012351 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 398527012352 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 398527012353 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 398527012354 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 398527012355 active site 398527012356 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 398527012357 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 398527012358 UDP-galactopyranose mutase; Region: GLF; pfam03275 398527012359 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 398527012360 putative active site [active] 398527012361 putative metal binding site [ion binding]; other site 398527012362 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 398527012363 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 398527012364 Protein of unknown function (DUF2471); Region: DUF2471; pfam10616 398527012365 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 398527012366 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 398527012367 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 398527012368 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 398527012369 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 398527012370 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 398527012371 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527012372 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 398527012373 oligomerisation interface [polypeptide binding]; other site 398527012374 mobile loop; other site 398527012375 roof hairpin; other site 398527012376 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 398527012377 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 398527012378 ring oligomerisation interface [polypeptide binding]; other site 398527012379 ATP/Mg binding site [chemical binding]; other site 398527012380 stacking interactions; other site 398527012381 hinge regions; other site 398527012382 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 398527012383 dimer interface [polypeptide binding]; other site 398527012384 substrate binding site [chemical binding]; other site 398527012385 ATP binding site [chemical binding]; other site 398527012386 Rubredoxin [Energy production and conversion]; Region: COG1773 398527012387 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 398527012388 iron binding site [ion binding]; other site 398527012389 hypothetical protein; Validated; Region: PRK00228 398527012390 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 398527012391 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 398527012392 active site 398527012393 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 398527012394 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 398527012395 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 398527012396 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 398527012397 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 398527012398 Probable transposase; Region: OrfB_IS605; pfam01385 398527012399 dihydroorotase; Provisional; Region: PRK07627 398527012400 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 398527012401 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 398527012402 active site 398527012403 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 398527012404 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 398527012405 putative acyl-acceptor binding pocket; other site 398527012406 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 398527012407 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 398527012408 active site 398527012409 metal binding site [ion binding]; metal-binding site 398527012410 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 398527012411 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 398527012412 NADP-binding site; other site 398527012413 homotetramer interface [polypeptide binding]; other site 398527012414 substrate binding site [chemical binding]; other site 398527012415 homodimer interface [polypeptide binding]; other site 398527012416 active site 398527012417 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 398527012418 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 398527012419 NAD binding site [chemical binding]; other site 398527012420 substrate binding site [chemical binding]; other site 398527012421 homodimer interface [polypeptide binding]; other site 398527012422 active site 398527012423 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 398527012424 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 398527012425 substrate binding site; other site 398527012426 tetramer interface; other site 398527012427 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 398527012428 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 398527012429 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 398527012430 NADP binding site [chemical binding]; other site 398527012431 active site 398527012432 putative substrate binding site [chemical binding]; other site 398527012433 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 398527012434 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 398527012435 Ligand binding site; other site 398527012436 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 398527012437 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 398527012438 Probable Catalytic site; other site 398527012439 metal-binding site 398527012440 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 398527012441 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 398527012442 Probable Catalytic site; other site 398527012443 metal-binding site 398527012444 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 398527012445 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 398527012446 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 398527012447 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 398527012448 active site 398527012449 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 398527012450 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 398527012451 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 398527012452 Walker A/P-loop; other site 398527012453 ATP binding site [chemical binding]; other site 398527012454 Q-loop/lid; other site 398527012455 ABC transporter signature motif; other site 398527012456 Walker B; other site 398527012457 D-loop; other site 398527012458 H-loop/switch region; other site 398527012459 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 398527012460 putative carbohydrate binding site [chemical binding]; other site 398527012461 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 398527012462 S-adenosylmethionine binding site [chemical binding]; other site 398527012463 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 398527012464 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 398527012465 putative ADP-binding pocket [chemical binding]; other site 398527012466 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 398527012467 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 398527012468 active site 398527012469 homodimer interface [polypeptide binding]; other site 398527012470 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 398527012471 Predicted membrane protein [Function unknown]; Region: COG2246 398527012472 GtrA-like protein; Region: GtrA; pfam04138 398527012473 hypothetical protein; Provisional; Region: PRK07233 398527012474 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 398527012475 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 398527012476 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 398527012477 NAD(P) binding site [chemical binding]; other site 398527012478 active site 398527012479 short chain dehydrogenase; Provisional; Region: PRK07102 398527012480 short chain dehydrogenase; Provisional; Region: PRK07024 398527012481 NAD(P) binding site [chemical binding]; other site 398527012482 active site 398527012483 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 398527012484 FAD binding domain; Region: FAD_binding_4; pfam01565 398527012485 Phosphoenolpyruvate carboxylase; Region: PEPcase_2; cl17501 398527012486 hypothetical protein; Validated; Region: PRK08238 398527012487 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 398527012488 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 398527012489 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 398527012490 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 398527012491 active site 398527012492 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 398527012493 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 398527012494 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 398527012495 putative NAD(P) binding site [chemical binding]; other site 398527012496 active site 398527012497 putative substrate binding site [chemical binding]; other site 398527012498 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 398527012499 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 398527012500 Mg++ binding site [ion binding]; other site 398527012501 putative catalytic motif [active] 398527012502 putative substrate binding site [chemical binding]; other site 398527012503 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 398527012504 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 398527012505 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 398527012506 NAD(P) binding site [chemical binding]; other site 398527012507 homodimer interface [polypeptide binding]; other site 398527012508 substrate binding site [chemical binding]; other site 398527012509 active site 398527012510 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 398527012511 This subfamily is composed of uncharacterized bacterial glycosyltransferases in the MraY-like family. This family contains both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases, which...; Region: GT_MraY_like; cd06912 398527012512 Mg++ binding site [ion binding]; other site 398527012513 putative catalytic motif [active] 398527012514 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 398527012515 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 398527012516 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 398527012517 dimerization interface [polypeptide binding]; other site 398527012518 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 398527012519 dimer interface [polypeptide binding]; other site 398527012520 putative CheW interface [polypeptide binding]; other site 398527012521 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 398527012522 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 398527012523 ligand binding site [chemical binding]; other site 398527012524 flexible hinge region; other site 398527012525 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 398527012526 putative switch regulator; other site 398527012527 non-specific DNA interactions [nucleotide binding]; other site 398527012528 DNA binding site [nucleotide binding] 398527012529 sequence specific DNA binding site [nucleotide binding]; other site 398527012530 putative cAMP binding site [chemical binding]; other site 398527012531 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 398527012532 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 398527012533 putative active site [active] 398527012534 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 398527012535 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 398527012536 putative ribose interaction site [chemical binding]; other site 398527012537 putative ADP binding site [chemical binding]; other site 398527012538 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 398527012539 putative active cleft [active] 398527012540 dimerization interface [polypeptide binding]; other site 398527012541 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 398527012542 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 398527012543 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 398527012544 Bacterial sugar transferase; Region: Bac_transf; pfam02397 398527012545 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 398527012546 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 398527012547 Walker A/P-loop; other site 398527012548 ATP binding site [chemical binding]; other site 398527012549 Q-loop/lid; other site 398527012550 ABC transporter signature motif; other site 398527012551 Walker B; other site 398527012552 D-loop; other site 398527012553 H-loop/switch region; other site 398527012554 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 398527012555 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 398527012556 TM-ABC transporter signature motif; other site 398527012557 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 398527012558 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 398527012559 Walker A/P-loop; other site 398527012560 ATP binding site [chemical binding]; other site 398527012561 Q-loop/lid; other site 398527012562 ABC transporter signature motif; other site 398527012563 Walker B; other site 398527012564 D-loop; other site 398527012565 H-loop/switch region; other site 398527012566 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 398527012567 TM-ABC transporter signature motif; other site 398527012568 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 398527012569 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_2; cd06335 398527012570 putative ligand binding site [chemical binding]; other site 398527012571 UDP-glucose 4-epimerase; Region: PLN02240 398527012572 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 398527012573 NAD binding site [chemical binding]; other site 398527012574 homodimer interface [polypeptide binding]; other site 398527012575 active site 398527012576 substrate binding site [chemical binding]; other site 398527012577 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 398527012578 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 398527012579 putative ADP-binding pocket [chemical binding]; other site 398527012580 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 398527012581 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 398527012582 active site 398527012583 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 398527012584 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 398527012585 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 398527012586 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 398527012587 active site 398527012588 substrate binding site [chemical binding]; other site 398527012589 metal binding site [ion binding]; metal-binding site 398527012590 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 398527012591 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 398527012592 putative active site [active] 398527012593 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase; Region: Kdo_hydroxy; pfam11004 398527012594 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 398527012595 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 398527012596 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 398527012597 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 398527012598 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 398527012599 UreF; Region: UreF; pfam01730 398527012600 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 398527012601 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 398527012602 dimer interface [polypeptide binding]; other site 398527012603 catalytic residues [active] 398527012604 urease subunit alpha; Reviewed; Region: ureC; PRK13207 398527012605 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 398527012606 subunit interactions [polypeptide binding]; other site 398527012607 active site 398527012608 flap region; other site 398527012609 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 398527012610 gamma-beta subunit interface [polypeptide binding]; other site 398527012611 alpha-beta subunit interface [polypeptide binding]; other site 398527012612 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 398527012613 alpha-gamma subunit interface [polypeptide binding]; other site 398527012614 beta-gamma subunit interface [polypeptide binding]; other site 398527012615 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 398527012616 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 398527012617 substrate binding pocket [chemical binding]; other site 398527012618 membrane-bound complex binding site; other site 398527012619 hinge residues; other site 398527012620 Acyltransferase family; Region: Acyl_transf_3; pfam01757 398527012621 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 398527012622 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 398527012623 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 398527012624 hypothetical protein; Provisional; Region: PRK08126 398527012625 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 398527012626 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 398527012627 ligand binding site [chemical binding]; other site 398527012628 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 398527012629 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 398527012630 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 398527012631 Protein of unknown function (DUF796); Region: DUF796; pfam05638 398527012632 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 398527012633 Protein of unknown function (DUF877); Region: DUF877; pfam05943 398527012634 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3516 398527012635 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 398527012636 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527012637 Walker A motif; other site 398527012638 ATP binding site [chemical binding]; other site 398527012639 Walker B motif; other site 398527012640 arginine finger; other site 398527012641 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527012642 Walker A motif; other site 398527012643 ATP binding site [chemical binding]; other site 398527012644 Walker B motif; other site 398527012645 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 398527012646 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 398527012647 ImpE protein; Region: ImpE; pfam07024 398527012648 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 398527012649 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 398527012650 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 398527012651 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 398527012652 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 398527012653 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 398527012654 UreD urease accessory protein; Region: UreD; cl00530 398527012655 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 398527012656 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 398527012657 Walker A/P-loop; other site 398527012658 ATP binding site [chemical binding]; other site 398527012659 Q-loop/lid; other site 398527012660 ABC transporter signature motif; other site 398527012661 Walker B; other site 398527012662 D-loop; other site 398527012663 H-loop/switch region; other site 398527012664 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 398527012665 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 398527012666 Walker A/P-loop; other site 398527012667 ATP binding site [chemical binding]; other site 398527012668 Q-loop/lid; other site 398527012669 ABC transporter signature motif; other site 398527012670 Walker B; other site 398527012671 D-loop; other site 398527012672 H-loop/switch region; other site 398527012673 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 398527012674 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 398527012675 TM-ABC transporter signature motif; other site 398527012676 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 398527012677 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 398527012678 TM-ABC transporter signature motif; other site 398527012679 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 398527012680 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 398527012681 putative ligand binding site [chemical binding]; other site 398527012682 Protein of unknown function (DUF3443); Region: DUF3443; pfam11925 398527012683 Protein of unknown function (DUF2844); Region: DUF2844; pfam11005 398527012684 Protein of unknown function (DUF3443); Region: DUF3443; pfam11925 398527012685 Protein of unknown function (DUF2844); Region: DUF2844; pfam11005 398527012686 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 398527012687 active site residue [active] 398527012688 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 398527012689 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 398527012690 S-adenosylmethionine binding site [chemical binding]; other site 398527012691 Transcriptional regulators [Transcription]; Region: PurR; COG1609 398527012692 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 398527012693 DNA binding site [nucleotide binding] 398527012694 domain linker motif; other site 398527012695 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 398527012696 dimerization interface [polypeptide binding]; other site 398527012697 ligand binding site [chemical binding]; other site 398527012698 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 398527012699 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 398527012700 Walker A/P-loop; other site 398527012701 ATP binding site [chemical binding]; other site 398527012702 Q-loop/lid; other site 398527012703 ABC transporter signature motif; other site 398527012704 Walker B; other site 398527012705 D-loop; other site 398527012706 H-loop/switch region; other site 398527012707 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 398527012708 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 398527012709 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 398527012710 TM-ABC transporter signature motif; other site 398527012711 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 398527012712 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_3; cd06311 398527012713 putative ligand binding site [chemical binding]; other site 398527012714 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 398527012715 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 398527012716 Metal-binding active site; metal-binding site 398527012717 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 398527012718 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 398527012719 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 398527012720 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 398527012721 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 398527012722 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 398527012723 putative ligand binding site [chemical binding]; other site 398527012724 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12684 398527012725 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527012726 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 398527012727 substrate binding site [chemical binding]; other site 398527012728 dimerization interface [polypeptide binding]; other site 398527012729 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 398527012730 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 398527012731 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 398527012732 Bacterial protein of unknown function (DUF934); Region: DUF934; cl01526 398527012733 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 398527012734 Active Sites [active] 398527012735 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 398527012736 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 398527012737 Active Sites [active] 398527012738 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 398527012739 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 398527012740 CysD dimerization site [polypeptide binding]; other site 398527012741 G1 box; other site 398527012742 putative GEF interaction site [polypeptide binding]; other site 398527012743 GTP/Mg2+ binding site [chemical binding]; other site 398527012744 Switch I region; other site 398527012745 G2 box; other site 398527012746 G3 box; other site 398527012747 Switch II region; other site 398527012748 G4 box; other site 398527012749 G5 box; other site 398527012750 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 398527012751 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 398527012752 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 398527012753 active site 398527012754 SAM binding site [chemical binding]; other site 398527012755 homodimer interface [polypeptide binding]; other site 398527012756 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 398527012757 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 398527012758 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527012759 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 398527012760 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527012761 D-galactonate transporter; Region: 2A0114; TIGR00893 398527012762 putative substrate translocation pore; other site 398527012763 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 398527012764 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 398527012765 NAD(P) binding site [chemical binding]; other site 398527012766 active site 398527012767 short chain dehydrogenase; Provisional; Region: PRK12829 398527012768 classical (c) SDRs; Region: SDR_c; cd05233 398527012769 NAD(P) binding site [chemical binding]; other site 398527012770 active site 398527012771 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 398527012772 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 398527012773 putative active site [active] 398527012774 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 398527012775 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 398527012776 Predicted permeases [General function prediction only]; Region: COG0795 398527012777 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 398527012778 multifunctional aminopeptidase A; Provisional; Region: PRK00913 398527012779 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 398527012780 interface (dimer of trimers) [polypeptide binding]; other site 398527012781 Substrate-binding/catalytic site; other site 398527012782 Zn-binding sites [ion binding]; other site 398527012783 DNA polymerase III subunit chi; Validated; Region: PRK05728 398527012784 Protein of unknown function (DUF2486); Region: DUF2486; pfam10667 398527012785 Cytochrome c; Region: Cytochrom_C; cl11414 398527012786 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 398527012787 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 398527012788 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527012789 The C-terminal substrate binding domain of LysR-type transcriptional regulator, IlvR, involved in the biosynthesis of isoleucine, leucine and valine; contains type 2 periplasmic binding fold; Region: PBP2_IlvR; cd08453 398527012790 putative dimerization interface [polypeptide binding]; other site 398527012791 putative substrate binding pocket [chemical binding]; other site 398527012792 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 398527012793 Protein of unknown function (DUF541); Region: SIMPL; cl01077 398527012794 EVE domain; Region: EVE; cl00728 398527012795 Cell division protein ZapA; Region: ZapA; pfam05164 398527012796 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 398527012797 primary dimer interface [polypeptide binding]; other site 398527012798 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 398527012799 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 398527012800 N-terminal plug; other site 398527012801 ligand-binding site [chemical binding]; other site 398527012802 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 398527012803 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 398527012804 ABC-ATPase subunit interface; other site 398527012805 dimer interface [polypeptide binding]; other site 398527012806 putative PBP binding regions; other site 398527012807 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 398527012808 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 398527012809 Walker A/P-loop; other site 398527012810 ATP binding site [chemical binding]; other site 398527012811 Q-loop/lid; other site 398527012812 ABC transporter signature motif; other site 398527012813 Walker B; other site 398527012814 D-loop; other site 398527012815 H-loop/switch region; other site 398527012816 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 398527012817 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 398527012818 putative dimer interface [polypeptide binding]; other site 398527012819 active site pocket [active] 398527012820 putative cataytic base [active] 398527012821 cobalamin synthase; Reviewed; Region: cobS; PRK00235 398527012822 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 398527012823 catalytic core [active] 398527012824 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 398527012825 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 398527012826 cobalamin binding residues [chemical binding]; other site 398527012827 putative BtuC binding residues; other site 398527012828 dimer interface [polypeptide binding]; other site 398527012829 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 398527012830 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 398527012831 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527012832 homodimer interface [polypeptide binding]; other site 398527012833 catalytic residue [active] 398527012834 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 398527012835 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 398527012836 homotrimer interface [polypeptide binding]; other site 398527012837 Walker A motif; other site 398527012838 GTP binding site [chemical binding]; other site 398527012839 Walker B motif; other site 398527012840 cobyric acid synthase; Provisional; Region: PRK00784 398527012841 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 398527012842 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 398527012843 catalytic triad [active] 398527012844 DoxX; Region: DoxX; pfam07681 398527012845 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 398527012846 CoenzymeA binding site [chemical binding]; other site 398527012847 subunit interaction site [polypeptide binding]; other site 398527012848 PHB binding site; other site 398527012849 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 398527012850 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 398527012851 P-loop; other site 398527012852 Magnesium ion binding site [ion binding]; other site 398527012853 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 398527012854 tetramerization interface [polypeptide binding]; other site 398527012855 active site 398527012856 pantoate--beta-alanine ligase; Region: panC; TIGR00018 398527012857 Pantoate-beta-alanine ligase; Region: PanC; cd00560 398527012858 active site 398527012859 ATP-binding site [chemical binding]; other site 398527012860 pantoate-binding site; other site 398527012861 HXXH motif; other site 398527012862 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 398527012863 Protein of unknown function (DUF3460); Region: DUF3460; pfam11943 398527012864 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 398527012865 Surface antigen; Region: Bac_surface_Ag; pfam01103 398527012866 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 398527012867 Family of unknown function (DUF490); Region: DUF490; pfam04357 398527012868 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 398527012869 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 398527012870 active site 398527012871 HIGH motif; other site 398527012872 KMSKS motif; other site 398527012873 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 398527012874 tRNA binding surface [nucleotide binding]; other site 398527012875 anticodon binding site; other site 398527012876 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 398527012877 dimer interface [polypeptide binding]; other site 398527012878 putative tRNA-binding site [nucleotide binding]; other site 398527012879 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 398527012880 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 398527012881 ligand binding site [chemical binding]; other site 398527012882 Domain of unknown function DUF59; Region: DUF59; pfam01883 398527012883 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 398527012884 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 398527012885 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 398527012886 Copper/zinc superoxide dismutase (SODC); Region: Sod_Cu; pfam00080 398527012887 E-class dimer interface [polypeptide binding]; other site 398527012888 P-class dimer interface [polypeptide binding]; other site 398527012889 active site 398527012890 Cu2+ binding site [ion binding]; other site 398527012891 Zn2+ binding site [ion binding]; other site 398527012892 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 398527012893 trimer interface [polypeptide binding]; other site 398527012894 active site 398527012895 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 398527012896 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 398527012897 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 398527012898 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 398527012899 catalytic residue [active] 398527012900 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 398527012901 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 398527012902 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 398527012903 Sulfatase; Region: Sulfatase; cl17466 398527012904 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 398527012905 Sulfatase; Region: Sulfatase; cl17466 398527012906 bifunctional glucokinase/RpiR family transcriptional regulator; Provisional; Region: PRK14101 398527012907 glucokinase; Provisional; Region: glk; PRK00292 398527012908 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 398527012909 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 398527012910 putative active site [active] 398527012911 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 398527012912 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 398527012913 putative active site [active] 398527012914 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 398527012915 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 398527012916 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 398527012917 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 398527012918 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 398527012919 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 398527012920 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527012921 putative PBP binding loops; other site 398527012922 ABC-ATPase subunit interface; other site 398527012923 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 398527012924 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527012925 dimer interface [polypeptide binding]; other site 398527012926 conserved gate region; other site 398527012927 putative PBP binding loops; other site 398527012928 ABC-ATPase subunit interface; other site 398527012929 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 398527012930 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 398527012931 Walker A/P-loop; other site 398527012932 ATP binding site [chemical binding]; other site 398527012933 Q-loop/lid; other site 398527012934 ABC transporter signature motif; other site 398527012935 Walker B; other site 398527012936 D-loop; other site 398527012937 H-loop/switch region; other site 398527012938 transcriptional regulator; Provisional; Region: PRK10632 398527012939 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527012940 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 398527012941 putative effector binding pocket; other site 398527012942 putative dimerization interface [polypeptide binding]; other site 398527012943 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 398527012944 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 398527012945 C-terminal domain interface [polypeptide binding]; other site 398527012946 GSH binding site (G-site) [chemical binding]; other site 398527012947 dimer interface [polypeptide binding]; other site 398527012948 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 398527012949 N-terminal domain interface [polypeptide binding]; other site 398527012950 dimer interface [polypeptide binding]; other site 398527012951 substrate binding pocket (H-site) [chemical binding]; other site 398527012952 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 398527012953 flagellar capping protein; Reviewed; Region: fliD; PRK08032 398527012954 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 398527012955 Predicted membrane protein [Function unknown]; Region: COG2860 398527012956 UPF0126 domain; Region: UPF0126; pfam03458 398527012957 UPF0126 domain; Region: UPF0126; pfam03458 398527012958 hypothetical protein; Provisional; Region: PRK04946 398527012959 Smr domain; Region: Smr; pfam01713 398527012960 thioredoxin reductase; Provisional; Region: PRK10262 398527012961 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 398527012962 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 398527012963 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 398527012964 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 398527012965 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 398527012966 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 398527012967 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 398527012968 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527012969 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527012970 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 398527012971 dimerization interface [polypeptide binding]; other site 398527012972 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 398527012973 agmatinase; Region: agmatinase; TIGR01230 398527012974 oligomer interface [polypeptide binding]; other site 398527012975 putative active site [active] 398527012976 Mn binding site [ion binding]; other site 398527012977 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 398527012978 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 398527012979 recombination factor protein RarA; Reviewed; Region: PRK13342 398527012980 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527012981 Walker A motif; other site 398527012982 ATP binding site [chemical binding]; other site 398527012983 Walker B motif; other site 398527012984 arginine finger; other site 398527012985 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 398527012986 seryl-tRNA synthetase; Provisional; Region: PRK05431 398527012987 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 398527012988 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 398527012989 dimer interface [polypeptide binding]; other site 398527012990 active site 398527012991 motif 1; other site 398527012992 motif 2; other site 398527012993 motif 3; other site 398527012994 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 398527012995 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 398527012996 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 398527012997 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 398527012998 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 398527012999 S-adenosylmethionine binding site [chemical binding]; other site 398527013000 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 398527013001 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 398527013002 substrate binding pocket [chemical binding]; other site 398527013003 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 398527013004 manganese transport protein MntH; Reviewed; Region: PRK00701 398527013005 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 398527013006 Ferritin-like domain; Region: Ferritin_2; pfam13668 398527013007 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 398527013008 active site 398527013009 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 398527013010 Coenzyme A binding pocket [chemical binding]; other site 398527013011 septum formation inhibitor; Reviewed; Region: PRK01973 398527013012 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 398527013013 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 398527013014 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 398527013015 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 398527013016 Switch I; other site 398527013017 Switch II; other site 398527013018 cell division topological specificity factor MinE; Provisional; Region: PRK13989 398527013019 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 398527013020 ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034 398527013021 putative ion selectivity filter; other site 398527013022 putative pore gating glutamate residue; other site 398527013023 putative H+/Cl- coupling transport residue; other site 398527013024 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 398527013025 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 398527013026 putative active site [active] 398527013027 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527013028 metabolite-proton symporter; Region: 2A0106; TIGR00883 398527013029 putative substrate translocation pore; other site 398527013030 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 398527013031 argininosuccinate lyase; Provisional; Region: PRK00855 398527013032 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 398527013033 active sites [active] 398527013034 tetramer interface [polypeptide binding]; other site 398527013035 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 398527013036 sequence-specific DNA binding site [nucleotide binding]; other site 398527013037 salt bridge; other site 398527013038 Methyltransferase domain; Region: Methyltransf_31; pfam13847 398527013039 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 398527013040 S-adenosylmethionine binding site [chemical binding]; other site 398527013041 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 398527013042 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 398527013043 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 398527013044 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 398527013045 domain interfaces; other site 398527013046 active site 398527013047 bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase; Reviewed; Region: PRK06975 398527013048 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 398527013049 active site 398527013050 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 398527013051 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 398527013052 HemY protein N-terminus; Region: HemY_N; pfam07219 398527013053 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 398527013054 TPR motif; other site 398527013055 binding surface 398527013056 RloB-like protein; Region: RloB; pfam13707 398527013057 Predicted ATPases [General function prediction only]; Region: COG1106 398527013058 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 398527013059 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 398527013060 active site 398527013061 DNA binding site [nucleotide binding] 398527013062 Int/Topo IB signature motif; other site 398527013063 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 398527013064 Putative transposase; Region: Y2_Tnp; pfam04986 398527013065 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 398527013066 SnoaL-like domain; Region: SnoaL_2; pfam12680 398527013067 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 398527013068 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527013069 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 398527013070 dimerization interface [polypeptide binding]; other site 398527013071 substrate binding pocket [chemical binding]; other site 398527013072 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 398527013073 putative effector binding pocket; other site 398527013074 dimerization interface [polypeptide binding]; other site 398527013075 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 398527013076 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 398527013077 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 398527013078 catalytic site [active] 398527013079 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 398527013080 SnoaL-like domain; Region: SnoaL_3; pfam13474 398527013081 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 398527013082 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 398527013083 Zn2+ binding site [ion binding]; other site 398527013084 Mg2+ binding site [ion binding]; other site 398527013085 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 398527013086 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 398527013087 conserved cys residue [active] 398527013088 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 398527013089 Zn2+ binding site [ion binding]; other site 398527013090 Mg2+ binding site [ion binding]; other site 398527013091 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 398527013092 zinc binding site [ion binding]; other site 398527013093 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 398527013094 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 398527013095 ligand binding site [chemical binding]; other site 398527013096 flexible hinge region; other site 398527013097 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 398527013098 putative switch regulator; other site 398527013099 non-specific DNA interactions [nucleotide binding]; other site 398527013100 DNA binding site [nucleotide binding] 398527013101 sequence specific DNA binding site [nucleotide binding]; other site 398527013102 putative cAMP binding site [chemical binding]; other site 398527013103 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 398527013104 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527013105 putative substrate translocation pore; other site 398527013106 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 3, classical (c) SDR; Region: BKR_3_SDR_c; cd05345 398527013107 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 398527013108 putative NAD(P) binding site [chemical binding]; other site 398527013109 active site 398527013110 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 398527013111 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 398527013112 NAD(P) binding site [chemical binding]; other site 398527013113 catalytic residues [active] 398527013114 catalytic residues [active] 398527013115 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 398527013116 dimer interface [polypeptide binding]; other site 398527013117 substrate binding site [chemical binding]; other site 398527013118 metal binding sites [ion binding]; metal-binding site 398527013119 Predicted transcriptional regulators [Transcription]; Region: COG1733 398527013120 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 398527013121 short chain dehydrogenase; Provisional; Region: PRK06500 398527013122 classical (c) SDRs; Region: SDR_c; cd05233 398527013123 NAD(P) binding site [chemical binding]; other site 398527013124 active site 398527013125 Domain of unknown function (DUF3331); Region: DUF3331; pfam11811 398527013126 Isochorismatase family; Region: Isochorismatase; pfam00857 398527013127 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 398527013128 catalytic triad [active] 398527013129 conserved cis-peptide bond; other site 398527013130 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 398527013131 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 398527013132 Coenzyme A binding pocket [chemical binding]; other site 398527013133 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 398527013134 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 398527013135 SnoaL-like domain; Region: SnoaL_2; pfam12680 398527013136 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 398527013137 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 398527013138 putative C-terminal domain interface [polypeptide binding]; other site 398527013139 putative GSH binding site (G-site) [chemical binding]; other site 398527013140 putative dimer interface [polypeptide binding]; other site 398527013141 C-terminal, alpha helical domain of an unknown subfamily 7 of Glutathione S-transferases; Region: GST_C_7; cd03206 398527013142 putative N-terminal domain interface [polypeptide binding]; other site 398527013143 putative dimer interface [polypeptide binding]; other site 398527013144 putative substrate binding pocket (H-site) [chemical binding]; other site 398527013145 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 398527013146 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 398527013147 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 398527013148 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 398527013149 FAD binding pocket [chemical binding]; other site 398527013150 FAD binding motif [chemical binding]; other site 398527013151 phosphate binding motif [ion binding]; other site 398527013152 beta-alpha-beta structure motif; other site 398527013153 NAD binding pocket [chemical binding]; other site 398527013154 Heme binding pocket [chemical binding]; other site 398527013155 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 398527013156 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 398527013157 catalytic loop [active] 398527013158 iron binding site [ion binding]; other site 398527013159 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 398527013160 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527013161 DNA-binding site [nucleotide binding]; DNA binding site 398527013162 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 398527013163 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527013164 homodimer interface [polypeptide binding]; other site 398527013165 catalytic residue [active] 398527013166 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 398527013167 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 398527013168 dimerization interface [polypeptide binding]; other site 398527013169 ligand binding site [chemical binding]; other site 398527013170 L-ectoine synthase; Reviewed; Region: ectC; PRK13290 398527013171 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527013172 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 398527013173 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527013174 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 398527013175 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 398527013176 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527013177 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 398527013178 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 398527013179 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 398527013180 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 398527013181 GIY-YIG motif/motif A; other site 398527013182 putative active site [active] 398527013183 putative metal binding site [ion binding]; other site 398527013184 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 398527013185 Protein of unknown function, DUF482; Region: DUF482; pfam04339 398527013186 NAD synthetase; Provisional; Region: PRK13981 398527013187 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 398527013188 multimer interface [polypeptide binding]; other site 398527013189 active site 398527013190 catalytic triad [active] 398527013191 protein interface 1 [polypeptide binding]; other site 398527013192 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 398527013193 homodimer interface [polypeptide binding]; other site 398527013194 NAD binding pocket [chemical binding]; other site 398527013195 ATP binding pocket [chemical binding]; other site 398527013196 Mg binding site [ion binding]; other site 398527013197 active-site loop [active] 398527013198 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 398527013199 Nitrogen regulatory protein P-II; Region: P-II; smart00938 398527013200 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 398527013201 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 398527013202 trimer interface [polypeptide binding]; other site 398527013203 eyelet of channel; other site 398527013204 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 398527013205 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 398527013206 Walker A/P-loop; other site 398527013207 ATP binding site [chemical binding]; other site 398527013208 Q-loop/lid; other site 398527013209 ABC transporter signature motif; other site 398527013210 Walker B; other site 398527013211 D-loop; other site 398527013212 H-loop/switch region; other site 398527013213 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 398527013214 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527013215 dimer interface [polypeptide binding]; other site 398527013216 conserved gate region; other site 398527013217 putative PBP binding loops; other site 398527013218 ABC-ATPase subunit interface; other site 398527013219 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 398527013220 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527013221 dimer interface [polypeptide binding]; other site 398527013222 conserved gate region; other site 398527013223 putative PBP binding loops; other site 398527013224 ABC-ATPase subunit interface; other site 398527013225 Pirin-related protein [General function prediction only]; Region: COG1741 398527013226 Pirin; Region: Pirin; pfam02678 398527013227 Heavy-metal resistance; Region: Metal_resist; pfam13801 398527013228 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 398527013229 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527013230 active site 398527013231 phosphorylation site [posttranslational modification] 398527013232 intermolecular recognition site; other site 398527013233 dimerization interface [polypeptide binding]; other site 398527013234 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 398527013235 DNA binding site [nucleotide binding] 398527013236 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 398527013237 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 398527013238 dimer interface [polypeptide binding]; other site 398527013239 phosphorylation site [posttranslational modification] 398527013240 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527013241 ATP binding site [chemical binding]; other site 398527013242 Mg2+ binding site [ion binding]; other site 398527013243 G-X-G motif; other site 398527013244 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 398527013245 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 398527013246 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 398527013247 metal binding site [ion binding]; metal-binding site 398527013248 active site 398527013249 I-site; other site 398527013250 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 398527013251 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527013252 dimer interface [polypeptide binding]; other site 398527013253 conserved gate region; other site 398527013254 putative PBP binding loops; other site 398527013255 ABC-ATPase subunit interface; other site 398527013256 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527013257 dimer interface [polypeptide binding]; other site 398527013258 conserved gate region; other site 398527013259 putative PBP binding loops; other site 398527013260 ABC-ATPase subunit interface; other site 398527013261 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 398527013262 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 398527013263 Walker A/P-loop; other site 398527013264 ATP binding site [chemical binding]; other site 398527013265 Q-loop/lid; other site 398527013266 ABC transporter signature motif; other site 398527013267 Walker B; other site 398527013268 D-loop; other site 398527013269 H-loop/switch region; other site 398527013270 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 398527013271 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 398527013272 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527013273 Walker A motif; other site 398527013274 ATP binding site [chemical binding]; other site 398527013275 Walker B motif; other site 398527013276 arginine finger; other site 398527013277 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 398527013278 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 398527013279 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 398527013280 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527013281 active site 398527013282 phosphorylation site [posttranslational modification] 398527013283 intermolecular recognition site; other site 398527013284 dimerization interface [polypeptide binding]; other site 398527013285 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527013286 Walker A motif; other site 398527013287 ATP binding site [chemical binding]; other site 398527013288 Walker B motif; other site 398527013289 arginine finger; other site 398527013290 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 398527013291 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 398527013292 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 398527013293 active site 398527013294 homotetramer interface [polypeptide binding]; other site 398527013295 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527013296 Major Facilitator Superfamily; Region: MFS_1; pfam07690 398527013297 putative substrate translocation pore; other site 398527013298 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 398527013299 substrate binding site [chemical binding]; other site 398527013300 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 398527013301 additional DNA contacts [nucleotide binding]; other site 398527013302 mismatch recognition site; other site 398527013303 active site 398527013304 zinc binding site [ion binding]; other site 398527013305 DNA intercalation site [nucleotide binding]; other site 398527013306 DNA cytosine methylase; Provisional; Region: PRK10458 398527013307 Helix-turn-helix; Region: HTH_3; pfam01381 398527013308 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 398527013309 cofactor binding site; other site 398527013310 DNA binding site [nucleotide binding] 398527013311 substrate interaction site [chemical binding]; other site 398527013312 CsbD-like; Region: CsbD; pfam05532 398527013313 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 398527013314 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 398527013315 C-terminal domain interface [polypeptide binding]; other site 398527013316 GSH binding site (G-site) [chemical binding]; other site 398527013317 dimer interface [polypeptide binding]; other site 398527013318 C-terminal, alpha helical domain of Ure2p and related Glutathione S-transferase-like proteins; Region: GST_C_Ure2p_like; cd03178 398527013319 dimer interface [polypeptide binding]; other site 398527013320 N-terminal domain interface [polypeptide binding]; other site 398527013321 Methyltransferase domain; Region: Methyltransf_12; pfam08242 398527013322 Methyltransferase domain; Region: Methyltransf_23; pfam13489 398527013323 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 398527013324 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 398527013325 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 398527013326 active site 398527013327 DNA binding site [nucleotide binding] 398527013328 Int/Topo IB signature motif; other site 398527013329 ParB-like nuclease domain; Region: ParBc; pfam02195 398527013330 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 398527013331 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 398527013332 cofactor binding site; other site 398527013333 DNA binding site [nucleotide binding] 398527013334 substrate interaction site [chemical binding]; other site 398527013335 ParB-like nuclease domain; Region: ParB; smart00470 398527013336 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 398527013337 non-specific DNA binding site [nucleotide binding]; other site 398527013338 salt bridge; other site 398527013339 sequence-specific DNA binding site [nucleotide binding]; other site 398527013340 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 398527013341 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 398527013342 Predicted P-loop ATPase and inactivated derivatives [General function prediction only]; Region: COG5545 398527013343 Virulence-associated protein E; Region: VirE; pfam05272 398527013344 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 398527013345 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 398527013346 Zn binding sites [ion binding]; other site 398527013347 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 398527013348 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 398527013349 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 398527013350 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 398527013351 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 398527013352 Uncharacterized conserved protein (DUF2190); Region: DUF2190; pfam09956 398527013353 Phage related hypothetical protein (DUF1799); Region: DUF1799; pfam08809 398527013354 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 398527013355 Phage-related minor tail protein [Function unknown]; Region: COG5281 398527013356 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 398527013357 catalytic residues [active] 398527013358 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 398527013359 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527013360 Walker A motif; other site 398527013361 ATP binding site [chemical binding]; other site 398527013362 Walker B motif; other site 398527013363 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 398527013364 Integrase core domain; Region: rve; pfam00665 398527013365 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 398527013366 Predicted periplasmic lipoprotein (DUF2279); Region: DUF2279; pfam10043 398527013367 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 398527013368 Rubredoxin; Region: Rubredoxin; pfam00301 398527013369 iron binding site [ion binding]; other site 398527013370 Domain of unknown function (DUF4399); Region: DUF4399; pfam14347 398527013371 ABC transporter ATPase component; Reviewed; Region: PRK11147 398527013372 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 398527013373 Walker A/P-loop; other site 398527013374 ATP binding site [chemical binding]; other site 398527013375 Q-loop/lid; other site 398527013376 ABC transporter signature motif; other site 398527013377 Walker B; other site 398527013378 D-loop; other site 398527013379 H-loop/switch region; other site 398527013380 ABC transporter; Region: ABC_tran_2; pfam12848 398527013381 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 398527013382 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 398527013383 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527013384 ATP binding site [chemical binding]; other site 398527013385 Mg2+ binding site [ion binding]; other site 398527013386 G-X-G motif; other site 398527013387 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 398527013388 anchoring element; other site 398527013389 dimer interface [polypeptide binding]; other site 398527013390 ATP binding site [chemical binding]; other site 398527013391 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 398527013392 active site 398527013393 metal binding site [ion binding]; metal-binding site 398527013394 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 398527013395 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 398527013396 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 398527013397 CAP-like domain; other site 398527013398 active site 398527013399 primary dimer interface [polypeptide binding]; other site 398527013400 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 398527013401 Predicted integral membrane protein [Function unknown]; Region: COG5615 398527013402 Chromate transporter; Region: Chromate_transp; pfam02417 398527013403 Chromate transporter; Region: Chromate_transp; pfam02417 398527013404 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 398527013405 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 398527013406 metal binding site [ion binding]; metal-binding site 398527013407 active site 398527013408 I-site; other site 398527013409 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 398527013410 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 398527013411 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 398527013412 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 398527013413 homotrimer interaction site [polypeptide binding]; other site 398527013414 putative active site [active] 398527013415 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 398527013416 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 398527013417 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527013418 homodimer interface [polypeptide binding]; other site 398527013419 catalytic residue [active] 398527013420 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 398527013421 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 398527013422 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527013423 DNA-binding site [nucleotide binding]; DNA binding site 398527013424 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 398527013425 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527013426 homodimer interface [polypeptide binding]; other site 398527013427 catalytic residue [active] 398527013428 heat shock protein 90; Provisional; Region: PRK05218 398527013429 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527013430 ATP binding site [chemical binding]; other site 398527013431 Mg2+ binding site [ion binding]; other site 398527013432 G-X-G motif; other site 398527013433 TPR repeat; Region: TPR_11; pfam13414 398527013434 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 398527013435 binding surface 398527013436 TPR motif; other site 398527013437 TPR repeat; Region: TPR_11; pfam13414 398527013438 TPR repeat; Region: TPR_11; pfam13414 398527013439 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 398527013440 binding surface 398527013441 TPR motif; other site 398527013442 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 398527013443 TPR motif; other site 398527013444 binding surface 398527013445 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 398527013446 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 398527013447 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 398527013448 ligand binding site [chemical binding]; other site 398527013449 Chorismate lyase; Region: Chor_lyase; cl01230 398527013450 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 398527013451 putative active site [active] 398527013452 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 398527013453 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 398527013454 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 398527013455 Na binding site [ion binding]; other site 398527013456 Predicted membrane protein [Function unknown]; Region: COG1289 398527013457 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 398527013458 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 398527013459 dimer interface [polypeptide binding]; other site 398527013460 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 398527013461 transaldolase-like protein; Provisional; Region: PTZ00411 398527013462 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 398527013463 active site 398527013464 dimer interface [polypeptide binding]; other site 398527013465 catalytic residue [active] 398527013466 Benzoate membrane transport protein; Region: BenE; pfam03594 398527013467 benzoate transporter; Region: benE; TIGR00843 398527013468 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 398527013469 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 398527013470 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527013471 Walker A motif; other site 398527013472 ATP binding site [chemical binding]; other site 398527013473 Walker B motif; other site 398527013474 arginine finger; other site 398527013475 Cytochrome c; Region: Cytochrom_C; cl11414 398527013476 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 398527013477 Cytochrome c553 [Energy production and conversion]; Region: COG2863 398527013478 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 398527013479 endonuclease III; Provisional; Region: PRK10702 398527013480 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 398527013481 minor groove reading motif; other site 398527013482 helix-hairpin-helix signature motif; other site 398527013483 substrate binding pocket [chemical binding]; other site 398527013484 active site 398527013485 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 398527013486 ferredoxin; Provisional; Region: PRK06991 398527013487 Putative Fe-S cluster; Region: FeS; pfam04060 398527013488 4Fe-4S binding domain; Region: Fer4; pfam00037 398527013489 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 398527013490 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 398527013491 Poly-beta-hydroxyalkanoate depolymerase [Lipid metabolism]; Region: DepA; COG4553 398527013492 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 398527013493 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 398527013494 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 398527013495 Protein of unknown function (DUF3096); Region: DUF3096; pfam11295 398527013496 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 398527013497 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 398527013498 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 398527013499 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 398527013500 META domain; Region: META; pfam03724 398527013501 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 398527013502 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 398527013503 ATP-grasp domain; Region: ATP-grasp; pfam02222 398527013504 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 398527013505 acetolactate synthase; Reviewed; Region: PRK08322 398527013506 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 398527013507 PYR/PP interface [polypeptide binding]; other site 398527013508 dimer interface [polypeptide binding]; other site 398527013509 TPP binding site [chemical binding]; other site 398527013510 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 398527013511 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 398527013512 TPP-binding site [chemical binding]; other site 398527013513 dimer interface [polypeptide binding]; other site 398527013514 Aldehyde dehydrogenase family 21A1-like; Region: ALDH_F21_RNP123; cd07147 398527013515 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 398527013516 NAD(P) binding site [chemical binding]; other site 398527013517 catalytic residues [active] 398527013518 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 398527013519 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 398527013520 ATP binding site [chemical binding]; other site 398527013521 Mg++ binding site [ion binding]; other site 398527013522 motif III; other site 398527013523 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 398527013524 nucleotide binding region [chemical binding]; other site 398527013525 ATP-binding site [chemical binding]; other site 398527013526 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 398527013527 glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838 398527013528 active site 398527013529 HIGH motif; other site 398527013530 nucleotide binding site [chemical binding]; other site 398527013531 active site 398527013532 KMSKS motif; other site 398527013533 rhodanese superfamily protein; Provisional; Region: PRK05320 398527013534 Acylphosphatase; Region: Acylphosphatase; cl00551 398527013535 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 398527013536 active site residue [active] 398527013537 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 398527013538 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 398527013539 putative active site [active] 398527013540 putative PHP Thumb interface [polypeptide binding]; other site 398527013541 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 398527013542 generic binding surface II; other site 398527013543 generic binding surface I; other site 398527013544 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 398527013545 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 398527013546 putative metal binding site; other site 398527013547 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 398527013548 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 398527013549 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 398527013550 Walker A/P-loop; other site 398527013551 ATP binding site [chemical binding]; other site 398527013552 Q-loop/lid; other site 398527013553 ABC transporter signature motif; other site 398527013554 Walker B; other site 398527013555 D-loop; other site 398527013556 H-loop/switch region; other site 398527013557 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 398527013558 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 398527013559 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 398527013560 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 398527013561 putative active site [active] 398527013562 O-Antigen ligase; Region: Wzy_C; pfam04932 398527013563 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 398527013564 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 398527013565 putative ADP-binding pocket [chemical binding]; other site 398527013566 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 398527013567 recombination associated protein; Reviewed; Region: rdgC; PRK00321 398527013568 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 398527013569 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 398527013570 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 398527013571 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 398527013572 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 398527013573 Spore Coat Protein U domain; Region: SCPU; pfam05229 398527013574 Spore Coat Protein U domain; Region: SCPU; pfam05229 398527013575 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 398527013576 PapC N-terminal domain; Region: PapC_N; pfam13954 398527013577 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 398527013578 PapC C-terminal domain; Region: PapC_C; pfam13953 398527013579 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 398527013580 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 398527013581 Uncharacterized secreted protein [Function unknown]; Region: COG5430 398527013582 H+ Antiporter protein; Region: 2A0121; TIGR00900 398527013583 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 398527013584 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 398527013585 dimer interface [polypeptide binding]; other site 398527013586 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 398527013587 putative dimer interface [polypeptide binding]; other site 398527013588 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 398527013589 NLPC_P60 stabilising domain, N term; Region: N_NLPC_P60; pfam12912 398527013590 SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913 398527013591 SH3 domain of SH3b2 type; Region: SH3_7; pfam12914 398527013592 NlpC/P60 family; Region: NLPC_P60; cl17555 398527013593 molybdenum-pterin binding domain; Region: Mop; TIGR00638 398527013594 TOBE domain; Region: TOBE; cl01440 398527013595 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 398527013596 PAS domain S-box; Region: sensory_box; TIGR00229 398527013597 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 398527013598 putative active site [active] 398527013599 heme pocket [chemical binding]; other site 398527013600 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 398527013601 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 398527013602 metal binding site [ion binding]; metal-binding site 398527013603 active site 398527013604 I-site; other site 398527013605 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 398527013606 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 398527013607 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 398527013608 Mechanosensitive ion channel; Region: MS_channel; pfam00924 398527013609 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299 398527013610 heme binding pocket [chemical binding]; other site 398527013611 PAS domain; Region: PAS_9; pfam13426 398527013612 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 398527013613 PAS fold; Region: PAS_3; pfam08447 398527013614 putative active site [active] 398527013615 heme pocket [chemical binding]; other site 398527013616 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 398527013617 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 398527013618 dimer interface [polypeptide binding]; other site 398527013619 phosphorylation site [posttranslational modification] 398527013620 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527013621 ATP binding site [chemical binding]; other site 398527013622 Mg2+ binding site [ion binding]; other site 398527013623 G-X-G motif; other site 398527013624 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527013625 Response regulator receiver domain; Region: Response_reg; pfam00072 398527013626 active site 398527013627 phosphorylation site [posttranslational modification] 398527013628 intermolecular recognition site; other site 398527013629 dimerization interface [polypeptide binding]; other site 398527013630 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 398527013631 PAS domain; Region: PAS; smart00091 398527013632 GAF domain; Region: GAF; pfam01590 398527013633 Phytochrome region; Region: PHY; pfam00360 398527013634 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 398527013635 dimer interface [polypeptide binding]; other site 398527013636 phosphorylation site [posttranslational modification] 398527013637 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527013638 ATP binding site [chemical binding]; other site 398527013639 Mg2+ binding site [ion binding]; other site 398527013640 G-X-G motif; other site 398527013641 Esterase PHB depolymerase; Region: Esterase_phd; pfam10503 398527013642 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 398527013643 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 398527013644 Methyltransferase domain; Region: Methyltransf_25; pfam13649 398527013645 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 398527013646 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 398527013647 dimer interface [polypeptide binding]; other site 398527013648 phosphorylation site [posttranslational modification] 398527013649 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527013650 ATP binding site [chemical binding]; other site 398527013651 Mg2+ binding site [ion binding]; other site 398527013652 G-X-G motif; other site 398527013653 Response regulator receiver domain; Region: Response_reg; pfam00072 398527013654 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527013655 active site 398527013656 phosphorylation site [posttranslational modification] 398527013657 intermolecular recognition site; other site 398527013658 dimerization interface [polypeptide binding]; other site 398527013659 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 398527013660 Response regulator receiver domain; Region: Response_reg; pfam00072 398527013661 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527013662 active site 398527013663 phosphorylation site [posttranslational modification] 398527013664 intermolecular recognition site; other site 398527013665 dimerization interface [polypeptide binding]; other site 398527013666 RibD C-terminal domain; Region: RibD_C; cl17279 398527013667 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 398527013668 Uncharacterized conserved protein [Function unknown]; Region: COG5361 398527013669 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 398527013670 ribonuclease G; Provisional; Region: PRK11712 398527013671 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 398527013672 homodimer interface [polypeptide binding]; other site 398527013673 oligonucleotide binding site [chemical binding]; other site 398527013674 Maf-like protein; Region: Maf; pfam02545 398527013675 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 398527013676 active site 398527013677 dimer interface [polypeptide binding]; other site 398527013678 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 398527013679 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 398527013680 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 398527013681 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 398527013682 active site 398527013683 (T/H)XGH motif; other site 398527013684 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 398527013685 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 398527013686 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 398527013687 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 398527013688 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 398527013689 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 398527013690 hypothetical protein; Validated; Region: PRK00110 398527013691 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 398527013692 active site 398527013693 short chain dehydrogenase; Provisional; Region: PRK08339 398527013694 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 398527013695 putative NAD(P) binding site [chemical binding]; other site 398527013696 putative active site [active] 398527013697 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 398527013698 active site 398527013699 dimer interfaces [polypeptide binding]; other site 398527013700 catalytic residues [active] 398527013701 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 398527013702 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 398527013703 NADP binding site [chemical binding]; other site 398527013704 dimer interface [polypeptide binding]; other site 398527013705 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 398527013706 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 398527013707 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 398527013708 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 398527013709 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 398527013710 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 398527013711 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 398527013712 Ligand Binding Site [chemical binding]; other site 398527013713 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 398527013714 GAF domain; Region: GAF_3; pfam13492 398527013715 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 398527013716 dimer interface [polypeptide binding]; other site 398527013717 phosphorylation site [posttranslational modification] 398527013718 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527013719 ATP binding site [chemical binding]; other site 398527013720 Mg2+ binding site [ion binding]; other site 398527013721 G-X-G motif; other site 398527013722 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 398527013723 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527013724 active site 398527013725 phosphorylation site [posttranslational modification] 398527013726 intermolecular recognition site; other site 398527013727 dimerization interface [polypeptide binding]; other site 398527013728 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 398527013729 DNA binding site [nucleotide binding] 398527013730 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 398527013731 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 398527013732 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 398527013733 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 398527013734 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 398527013735 apolar tunnel; other site 398527013736 heme binding site [chemical binding]; other site 398527013737 dimerization interface [polypeptide binding]; other site 398527013738 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 398527013739 glucose-1-dehydrogenase; Provisional; Region: PRK06947 398527013740 classical (c) SDRs; Region: SDR_c; cd05233 398527013741 NAD(P) binding site [chemical binding]; other site 398527013742 active site 398527013743 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 398527013744 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 398527013745 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 398527013746 Bacterial transcriptional repressor; Region: TetR; pfam13972 398527013747 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 398527013748 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 398527013749 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 398527013750 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 398527013751 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 398527013752 putative active site [active] 398527013753 putative metal binding site [ion binding]; other site 398527013754 RDD family; Region: RDD; pfam06271 398527013755 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 398527013756 Protein of unknown function (DUF3619); Region: DUF3619; pfam12279 398527013757 RNA polymerase factor sigma-70; Validated; Region: PRK09047 398527013758 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 398527013759 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 398527013760 DNA binding residues [nucleotide binding] 398527013761 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06965 398527013762 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 398527013763 PYR/PP interface [polypeptide binding]; other site 398527013764 dimer interface [polypeptide binding]; other site 398527013765 TPP binding site [chemical binding]; other site 398527013766 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 398527013767 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 398527013768 TPP-binding site [chemical binding]; other site 398527013769 dimer interface [polypeptide binding]; other site 398527013770 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 398527013771 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 398527013772 putative valine binding site [chemical binding]; other site 398527013773 dimer interface [polypeptide binding]; other site 398527013774 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 398527013775 ketol-acid reductoisomerase; Provisional; Region: PRK05479 398527013776 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 398527013777 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 398527013778 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 398527013779 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 398527013780 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 398527013781 2-isopropylmalate synthase; Validated; Region: PRK00915 398527013782 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 398527013783 active site 398527013784 catalytic residues [active] 398527013785 metal binding site [ion binding]; metal-binding site 398527013786 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 398527013787 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 398527013788 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 398527013789 Sulfate transporter family; Region: Sulfate_transp; pfam00916 398527013790 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 398527013791 active site clefts [active] 398527013792 zinc binding site [ion binding]; other site 398527013793 dimer interface [polypeptide binding]; other site 398527013794 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 398527013795 Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329 398527013796 putative ligand binding site [chemical binding]; other site 398527013797 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 398527013798 16S/18S rRNA binding site [nucleotide binding]; other site 398527013799 S13e-L30e interaction site [polypeptide binding]; other site 398527013800 25S rRNA binding site [nucleotide binding]; other site 398527013801 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 398527013802 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 398527013803 RNase E interface [polypeptide binding]; other site 398527013804 trimer interface [polypeptide binding]; other site 398527013805 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 398527013806 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 398527013807 RNase E interface [polypeptide binding]; other site 398527013808 trimer interface [polypeptide binding]; other site 398527013809 active site 398527013810 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 398527013811 putative nucleic acid binding region [nucleotide binding]; other site 398527013812 G-X-X-G motif; other site 398527013813 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 398527013814 RNA binding site [nucleotide binding]; other site 398527013815 domain interface; other site 398527013816 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 398527013817 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 398527013818 NAD(P) binding site [chemical binding]; other site 398527013819 triosephosphate isomerase; Provisional; Region: PRK14567 398527013820 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 398527013821 substrate binding site [chemical binding]; other site 398527013822 dimer interface [polypeptide binding]; other site 398527013823 catalytic triad [active] 398527013824 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 398527013825 NADH dehydrogenase subunit B; Validated; Region: PRK06411 398527013826 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 398527013827 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 398527013828 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 398527013829 NADH dehydrogenase subunit D; Validated; Region: PRK06075 398527013830 NADH dehydrogenase subunit E; Validated; Region: PRK07539 398527013831 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 398527013832 putative dimer interface [polypeptide binding]; other site 398527013833 [2Fe-2S] cluster binding site [ion binding]; other site 398527013834 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 398527013835 SLBB domain; Region: SLBB; pfam10531 398527013836 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 398527013837 NADH dehydrogenase subunit G; Validated; Region: PRK09129 398527013838 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 398527013839 catalytic loop [active] 398527013840 iron binding site [ion binding]; other site 398527013841 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 398527013842 MopB_NDH-1_NuoG2: The second domain of the NuoG subunit of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1), found in beta- and gammaproteobacteria. The NDH-1 is the first energy-transducting complex in the respiratory chain and functions as...; Region: MopB_NDH-1_NuoG2; cd02772 398527013843 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 398527013844 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 398527013845 4Fe-4S binding domain; Region: Fer4; cl02805 398527013846 4Fe-4S binding domain; Region: Fer4; pfam00037 398527013847 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 398527013848 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 398527013849 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 398527013850 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 398527013851 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 398527013852 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 398527013853 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 398527013854 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 398527013855 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 398527013856 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 398527013857 Protein of unknown function (DUF2818); Region: DUF2818; pfam10993 398527013858 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 398527013859 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 398527013860 dimer interface [polypeptide binding]; other site 398527013861 ADP-ribose binding site [chemical binding]; other site 398527013862 active site 398527013863 nudix motif; other site 398527013864 metal binding site [ion binding]; metal-binding site 398527013865 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 398527013866 Protein of unknown function (DUF1178); Region: DUF1178; pfam06676 398527013867 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 398527013868 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 398527013869 FAD binding site [chemical binding]; other site 398527013870 substrate binding site [chemical binding]; other site 398527013871 catalytic base [active] 398527013872 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 398527013873 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 398527013874 active site 398527013875 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 398527013876 putative active site [active] 398527013877 putative catalytic site [active] 398527013878 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 398527013879 putative active site [active] 398527013880 putative catalytic site [active] 398527013881 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 398527013882 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 398527013883 C-terminal domain interface [polypeptide binding]; other site 398527013884 GSH binding site (G-site) [chemical binding]; other site 398527013885 dimer interface [polypeptide binding]; other site 398527013886 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 398527013887 N-terminal domain interface [polypeptide binding]; other site 398527013888 putative dimer interface [polypeptide binding]; other site 398527013889 active site 398527013890 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 398527013891 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 398527013892 FAD binding site [chemical binding]; other site 398527013893 substrate binding site [chemical binding]; other site 398527013894 catalytic base [active] 398527013895 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 398527013896 putative active site [active] 398527013897 putative substrate binding site [chemical binding]; other site 398527013898 ATP binding site [chemical binding]; other site 398527013899 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 398527013900 catalytic core [active] 398527013901 enoyl-CoA hydratase; Provisional; Region: PRK07511 398527013902 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 398527013903 substrate binding site [chemical binding]; other site 398527013904 oxyanion hole (OAH) forming residues; other site 398527013905 trimer interface [polypeptide binding]; other site 398527013906 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 398527013907 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 398527013908 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 398527013909 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 398527013910 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 398527013911 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 398527013912 C-terminal domain interface [polypeptide binding]; other site 398527013913 GSH binding site (G-site) [chemical binding]; other site 398527013914 dimer interface [polypeptide binding]; other site 398527013915 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 398527013916 N-terminal domain interface [polypeptide binding]; other site 398527013917 dimer interface [polypeptide binding]; other site 398527013918 substrate binding pocket (H-site) [chemical binding]; other site 398527013919 methionine aminotransferase; Validated; Region: PRK09082 398527013920 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 398527013921 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527013922 homodimer interface [polypeptide binding]; other site 398527013923 catalytic residue [active] 398527013924 PIN domain; Region: PIN_3; pfam13470 398527013925 hypothetical protein; Validated; Region: PRK02101 398527013926 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 398527013927 Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases; uncharacterized bacterial subgroup; Region: M14_Nna1_like_1; cd06234 398527013928 putative active site [active] 398527013929 Zn binding site [ion binding]; other site 398527013930 Predicted membrane protein [Function unknown]; Region: COG3235 398527013931 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 398527013932 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 398527013933 active site 398527013934 phosphorylation site [posttranslational modification] 398527013935 intermolecular recognition site; other site 398527013936 dimerization interface [polypeptide binding]; other site 398527013937 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 398527013938 DNA binding residues [nucleotide binding] 398527013939 dimerization interface [polypeptide binding]; other site 398527013940 Protein of unknown function (DUF2863); Region: DUF2863; pfam11062 398527013941 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 398527013942 Uncharacterized conserved protein [Function unknown]; Region: COG4544 398527013943 DNA Polymerase Y-family; Region: PolY_like; cd03468 398527013944 DNA binding site [nucleotide binding] 398527013945 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 398527013946 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 398527013947 putative active site [active] 398527013948 putative PHP Thumb interface [polypeptide binding]; other site 398527013949 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 398527013950 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 398527013951 generic binding surface II; other site 398527013952 generic binding surface I; other site 398527013953 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 398527013954 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 398527013955 NADP binding site [chemical binding]; other site 398527013956 active site 398527013957 putative substrate binding site [chemical binding]; other site 398527013958 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 398527013959 metal-binding site [ion binding] 398527013960 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 398527013961 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 398527013962 DNA binding residues [nucleotide binding] 398527013963 dimer interface [polypeptide binding]; other site 398527013964 copper binding site [ion binding]; other site 398527013965 Protein of unknown function (DUF3563); Region: DUF3563; pfam12086 398527013966 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 398527013967 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 398527013968 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 398527013969 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 398527013970 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 398527013971 active site 398527013972 catalytic tetrad [active] 398527013973 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK13394 398527013974 classical (c) SDRs; Region: SDR_c; cd05233 398527013975 NAD(P) binding site [chemical binding]; other site 398527013976 active site 398527013977 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 398527013978 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 398527013979 nucleophile elbow; other site 398527013980 Patatin phospholipase; Region: DUF3734; pfam12536 398527013981 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 398527013982 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 398527013983 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527013984 homodimer interface [polypeptide binding]; other site 398527013985 catalytic residue [active] 398527013986 excinuclease ABC subunit B; Provisional; Region: PRK05298 398527013987 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 398527013988 ATP binding site [chemical binding]; other site 398527013989 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 398527013990 nucleotide binding region [chemical binding]; other site 398527013991 ATP-binding site [chemical binding]; other site 398527013992 Ultra-violet resistance protein B; Region: UvrB; pfam12344 398527013993 UvrB/uvrC motif; Region: UVR; pfam02151 398527013994 Fe2+ transport protein; Region: Iron_transport; pfam10634 398527013995 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 398527013996 Iron permease FTR1 family; Region: FTR1; cl00475 398527013997 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 398527013998 4Fe-4S binding domain; Region: Fer4_5; pfam12801 398527013999 Hemin uptake protein hemP; Region: hemP; pfam10636 398527014000 DUF1857, an uncharacterized ligand-binding domain of the SRPBCC domain superfamily; Region: SRPBCC_DUF1857; cd08863 398527014001 putative hydrophobic ligand binding site [chemical binding]; other site 398527014002 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 398527014003 Pirin-related protein [General function prediction only]; Region: COG1741 398527014004 Pirin; Region: Pirin; pfam02678 398527014005 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 398527014006 LysR family transcriptional regulator; Provisional; Region: PRK14997 398527014007 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527014008 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 398527014009 putative effector binding pocket; other site 398527014010 putative dimerization interface [polypeptide binding]; other site 398527014011 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 398527014012 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 398527014013 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 398527014014 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 398527014015 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 398527014016 Bacterioferritin-associated ferredoxin [Inorganic ion transport and metabolism]; Region: Bfd; COG2906 398527014017 glutamate racemase; Provisional; Region: PRK00865 398527014018 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 398527014019 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 398527014020 heme binding site [chemical binding]; other site 398527014021 ferroxidase pore; other site 398527014022 ferroxidase diiron center [ion binding]; other site 398527014023 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 398527014024 Fumarase C-terminus; Region: Fumerase_C; pfam05683 398527014025 hypothetical protein; Provisional; Region: PRK05208 398527014026 EamA-like transporter family; Region: EamA; pfam00892 398527014027 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 398527014028 EamA-like transporter family; Region: EamA; pfam00892 398527014029 acetyl-CoA synthetase; Provisional; Region: PRK00174 398527014030 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 398527014031 active site 398527014032 CoA binding site [chemical binding]; other site 398527014033 acyl-activating enzyme (AAE) consensus motif; other site 398527014034 AMP binding site [chemical binding]; other site 398527014035 acetate binding site [chemical binding]; other site 398527014036 Domain of unknown function (DUF4212); Region: DUF4212; pfam13937 398527014037 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 398527014038 probable sodium:solute symporter, VC_2705 subfamily; Region: Na_symport_lg; TIGR03648 398527014039 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 398527014040 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 398527014041 enterobactin exporter EntS; Provisional; Region: PRK10489 398527014042 EamA-like transporter family; Region: EamA; pfam00892 398527014043 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 398527014044 EamA-like transporter family; Region: EamA; pfam00892 398527014045 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527014046 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527014047 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 398527014048 putative effector binding pocket; other site 398527014049 dimerization interface [polypeptide binding]; other site 398527014050 L-asparaginase II; Region: Asparaginase_II; pfam06089 398527014051 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 398527014052 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 398527014053 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527014054 active site 398527014055 phosphorylation site [posttranslational modification] 398527014056 intermolecular recognition site; other site 398527014057 dimerization interface [polypeptide binding]; other site 398527014058 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 398527014059 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 398527014060 binding surface 398527014061 TPR motif; other site 398527014062 TPR repeat; Region: TPR_11; pfam13414 398527014063 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 398527014064 binding surface 398527014065 TPR motif; other site 398527014066 TPR repeat; Region: TPR_11; pfam13414 398527014067 TPR repeat; Region: TPR_11; pfam13414 398527014068 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 398527014069 binding surface 398527014070 TPR motif; other site 398527014071 TPR repeat; Region: TPR_11; pfam13414 398527014072 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 398527014073 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 398527014074 active site 398527014075 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 398527014076 catalytic tetrad [active] 398527014077 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 398527014078 short chain dehydrogenase; Provisional; Region: PRK12937 398527014079 NADP binding site [chemical binding]; other site 398527014080 homodimer interface [polypeptide binding]; other site 398527014081 active site 398527014082 substrate binding site [chemical binding]; other site 398527014083 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527014084 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527014085 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 398527014086 putative effector binding pocket; other site 398527014087 putative dimerization interface [polypeptide binding]; other site 398527014088 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 398527014089 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 398527014090 active site 398527014091 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 398527014092 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 398527014093 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 398527014094 putative dimer interface [polypeptide binding]; other site 398527014095 N-terminal domain interface [polypeptide binding]; other site 398527014096 putative substrate binding pocket (H-site) [chemical binding]; other site 398527014097 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 398527014098 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527014099 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 398527014100 dimerization interface [polypeptide binding]; other site 398527014101 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 398527014102 ssDNA binding site [nucleotide binding]; other site 398527014103 tetramer (dimer of dimers) interface [polypeptide binding]; other site 398527014104 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 398527014105 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527014106 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 398527014107 dimerization interface [polypeptide binding]; other site 398527014108 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 398527014109 active site 398527014110 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 398527014111 CoA-transferase family III; Region: CoA_transf_3; pfam02515 398527014112 metabolite-proton symporter; Region: 2A0106; TIGR00883 398527014113 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527014114 putative substrate translocation pore; other site 398527014115 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 398527014116 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 398527014117 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 398527014118 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 398527014119 Walker A/P-loop; other site 398527014120 ATP binding site [chemical binding]; other site 398527014121 Q-loop/lid; other site 398527014122 ABC transporter signature motif; other site 398527014123 Walker B; other site 398527014124 D-loop; other site 398527014125 H-loop/switch region; other site 398527014126 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 398527014127 Walker A/P-loop; other site 398527014128 ATP binding site [chemical binding]; other site 398527014129 Q-loop/lid; other site 398527014130 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 398527014131 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 398527014132 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 398527014133 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 398527014134 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 398527014135 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 398527014136 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 398527014137 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 398527014138 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 398527014139 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 398527014140 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 398527014141 non-specific DNA binding site [nucleotide binding]; other site 398527014142 salt bridge; other site 398527014143 sequence-specific DNA binding site [nucleotide binding]; other site 398527014144 Cupin domain; Region: Cupin_2; pfam07883 398527014145 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 398527014146 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 398527014147 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 398527014148 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 398527014149 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 398527014150 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 398527014151 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527014152 dimer interface [polypeptide binding]; other site 398527014153 conserved gate region; other site 398527014154 putative PBP binding loops; other site 398527014155 ABC-ATPase subunit interface; other site 398527014156 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 398527014157 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527014158 dimer interface [polypeptide binding]; other site 398527014159 conserved gate region; other site 398527014160 putative PBP binding loops; other site 398527014161 ABC-ATPase subunit interface; other site 398527014162 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 398527014163 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 398527014164 Walker A/P-loop; other site 398527014165 ATP binding site [chemical binding]; other site 398527014166 Q-loop/lid; other site 398527014167 ABC transporter signature motif; other site 398527014168 Walker B; other site 398527014169 D-loop; other site 398527014170 H-loop/switch region; other site 398527014171 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 398527014172 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 398527014173 Walker A/P-loop; other site 398527014174 ATP binding site [chemical binding]; other site 398527014175 Q-loop/lid; other site 398527014176 ABC transporter signature motif; other site 398527014177 Walker B; other site 398527014178 D-loop; other site 398527014179 H-loop/switch region; other site 398527014180 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 398527014181 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 398527014182 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 398527014183 putative acetyltransferase YhhY; Provisional; Region: PRK10140 398527014184 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 398527014185 Coenzyme A binding pocket [chemical binding]; other site 398527014186 putative acetyltransferase YhhY; Provisional; Region: PRK10140 398527014187 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 398527014188 Coenzyme A binding pocket [chemical binding]; other site 398527014189 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 398527014190 Protein export membrane protein; Region: SecD_SecF; cl14618 398527014191 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 398527014192 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 398527014193 conserved cys residue [active] 398527014194 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527014195 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527014196 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 398527014197 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 398527014198 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527014199 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 398527014200 dimerization interface [polypeptide binding]; other site 398527014201 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 398527014202 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 398527014203 Coenzyme A binding pocket [chemical binding]; other site 398527014204 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527014205 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527014206 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 398527014207 dimerization interface [polypeptide binding]; other site 398527014208 2-hydroxymuconic semialdehyde dehydrogenase; Region: OH_muco_semi_DH; TIGR03216 398527014209 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 398527014210 NAD binding site [chemical binding]; other site 398527014211 catalytic residues [active] 398527014212 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 398527014213 acetaldehyde dehydrogenase; Validated; Region: PRK08300 398527014214 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 398527014215 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 398527014216 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 398527014217 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 398527014218 active site 398527014219 catalytic residues [active] 398527014220 metal binding site [ion binding]; metal-binding site 398527014221 DmpG-like communication domain; Region: DmpG_comm; pfam07836 398527014222 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 398527014223 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 398527014224 homotrimer interaction site [polypeptide binding]; other site 398527014225 putative active site [active] 398527014226 3-hydroxyanthranilate 3,4-dioxygenase; Provisional; Region: PRK13264 398527014227 Amidohydrolase; Region: Amidohydro_2; pfam04909 398527014228 Kynureninase [Amino acid transport and metabolism]; Region: COG3844 398527014229 kynureninase; Region: kynureninase; TIGR01814 398527014230 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 398527014231 catalytic residue [active] 398527014232 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 398527014233 Cytochrome c; Region: Cytochrom_C; cl11414 398527014234 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 398527014235 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 398527014236 trimer interface [polypeptide binding]; other site 398527014237 eyelet of channel; other site 398527014238 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 398527014239 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 398527014240 trimer interface [polypeptide binding]; other site 398527014241 eyelet of channel; other site 398527014242 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 398527014243 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 398527014244 putative ligand binding site [chemical binding]; other site 398527014245 NAD binding site [chemical binding]; other site 398527014246 catalytic site [active] 398527014247 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 398527014248 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 398527014249 active site 398527014250 metal binding site [ion binding]; metal-binding site 398527014251 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 398527014252 substrate binding pocket [chemical binding]; other site 398527014253 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 398527014254 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 398527014255 inhibitor site; inhibition site 398527014256 active site 398527014257 dimer interface [polypeptide binding]; other site 398527014258 catalytic residue [active] 398527014259 Transcriptional regulators [Transcription]; Region: GntR; COG1802 398527014260 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527014261 DNA-binding site [nucleotide binding]; DNA binding site 398527014262 FCD domain; Region: FCD; pfam07729 398527014263 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 398527014264 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 398527014265 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 398527014266 NMT1/THI5 like; Region: NMT1; pfam09084 398527014267 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 398527014268 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 398527014269 active site 398527014270 metal binding site [ion binding]; metal-binding site 398527014271 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 398527014272 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527014273 dimer interface [polypeptide binding]; other site 398527014274 conserved gate region; other site 398527014275 putative PBP binding loops; other site 398527014276 ABC-ATPase subunit interface; other site 398527014277 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 398527014278 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 398527014279 Walker A/P-loop; other site 398527014280 ATP binding site [chemical binding]; other site 398527014281 Q-loop/lid; other site 398527014282 ABC transporter signature motif; other site 398527014283 Walker B; other site 398527014284 D-loop; other site 398527014285 H-loop/switch region; other site 398527014286 Spherulation-specific family 4; Region: Spherulin4; pfam12138 398527014287 TM1410 hypothetical-related protein; Region: DUF297; cl00997 398527014288 C-terminal Putative NodB-like catalytic domain of PelA-like uncharacterized hypothetical proteins found in bacteria; Region: CE4_PelA_like_C; cd10922 398527014289 putative active site [active] 398527014290 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 398527014291 Tetratricopeptide repeat; Region: TPR_15; pfam13429 398527014292 Predicted integral membrane protein [Function unknown]; Region: COG5616 398527014293 poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939 398527014294 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813 398527014295 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 398527014296 Predicted membrane protein [Function unknown]; Region: COG4267 398527014297 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 398527014298 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 398527014299 UDP-glucose 4-epimerase; Region: PLN02240 398527014300 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 398527014301 NAD binding site [chemical binding]; other site 398527014302 homodimer interface [polypeptide binding]; other site 398527014303 active site 398527014304 substrate binding site [chemical binding]; other site 398527014305 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 398527014306 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 398527014307 glutaminase active site [active] 398527014308 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 398527014309 dimer interface [polypeptide binding]; other site 398527014310 active site 398527014311 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 398527014312 dimer interface [polypeptide binding]; other site 398527014313 active site 398527014314 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 398527014315 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 398527014316 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 398527014317 Zn2+ binding site [ion binding]; other site 398527014318 Mg2+ binding site [ion binding]; other site 398527014319 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 398527014320 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 398527014321 DNA binding residues [nucleotide binding] 398527014322 dimerization interface [polypeptide binding]; other site 398527014323 Lysine efflux permease [General function prediction only]; Region: COG1279 398527014324 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 398527014325 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527014326 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 398527014327 dimerization interface [polypeptide binding]; other site 398527014328 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 398527014329 active site clefts [active] 398527014330 zinc binding site [ion binding]; other site 398527014331 dimer interface [polypeptide binding]; other site 398527014332 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 398527014333 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 398527014334 dimerization interface [polypeptide binding]; other site 398527014335 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 398527014336 dimer interface [polypeptide binding]; other site 398527014337 phosphorylation site [posttranslational modification] 398527014338 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527014339 ATP binding site [chemical binding]; other site 398527014340 Mg2+ binding site [ion binding]; other site 398527014341 G-X-G motif; other site 398527014342 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 398527014343 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527014344 active site 398527014345 phosphorylation site [posttranslational modification] 398527014346 intermolecular recognition site; other site 398527014347 dimerization interface [polypeptide binding]; other site 398527014348 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 398527014349 DNA binding site [nucleotide binding] 398527014350 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 398527014351 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 398527014352 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527014353 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527014354 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 398527014355 putative dimerization interface [polypeptide binding]; other site 398527014356 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 398527014357 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 398527014358 Na binding site [ion binding]; other site 398527014359 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 398527014360 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 398527014361 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 398527014362 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 398527014363 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 398527014364 NAD binding site [chemical binding]; other site 398527014365 catalytic residues [active] 398527014366 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 398527014367 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527014368 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 398527014369 dimerization interface [polypeptide binding]; other site 398527014370 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 398527014371 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 398527014372 metal binding site [ion binding]; metal-binding site 398527014373 putative dimer interface [polypeptide binding]; other site 398527014374 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527014375 metabolite-proton symporter; Region: 2A0106; TIGR00883 398527014376 putative substrate translocation pore; other site 398527014377 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527014378 Major Facilitator Superfamily; Region: MFS_1; pfam07690 398527014379 putative substrate translocation pore; other site 398527014380 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 398527014381 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 398527014382 putative hydrophobic ligand binding site [chemical binding]; other site 398527014383 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 398527014384 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 398527014385 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 398527014386 NAD(P) binding site [chemical binding]; other site 398527014387 active site 398527014388 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527014389 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527014390 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 398527014391 dimerization interface [polypeptide binding]; other site 398527014392 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 398527014393 active sites [active] 398527014394 tetramer interface [polypeptide binding]; other site 398527014395 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 398527014396 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527014397 DNA-binding site [nucleotide binding]; DNA binding site 398527014398 UTRA domain; Region: UTRA; pfam07702 398527014399 urocanate hydratase; Provisional; Region: PRK05414 398527014400 HutD; Region: HutD; pfam05962 398527014401 imidazolonepropionase; Validated; Region: PRK09356 398527014402 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 398527014403 active site 398527014404 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 398527014405 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 398527014406 active site 398527014407 N-formylglutamate amidohydrolase; Region: FGase; cl01522 398527014408 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 398527014409 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 398527014410 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 398527014411 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 398527014412 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 398527014413 dimerization interface [polypeptide binding]; other site 398527014414 ligand binding site [chemical binding]; other site 398527014415 pyridoxamine kinase; Validated; Region: PRK05756 398527014416 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 398527014417 dimer interface [polypeptide binding]; other site 398527014418 pyridoxal binding site [chemical binding]; other site 398527014419 ATP binding site [chemical binding]; other site 398527014420 glycogen synthase; Provisional; Region: glgA; PRK00654 398527014421 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 398527014422 ADP-binding pocket [chemical binding]; other site 398527014423 homodimer interface [polypeptide binding]; other site 398527014424 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 398527014425 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 398527014426 ligand binding site; other site 398527014427 oligomer interface; other site 398527014428 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 398527014429 dimer interface [polypeptide binding]; other site 398527014430 N-terminal domain interface [polypeptide binding]; other site 398527014431 sulfate 1 binding site; other site 398527014432 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 398527014433 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 398527014434 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 398527014435 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 398527014436 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 398527014437 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 398527014438 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 398527014439 dimer interface [polypeptide binding]; other site 398527014440 active site 398527014441 non-prolyl cis peptide bond; other site 398527014442 insertion regions; other site 398527014443 hypothetical protein; Provisional; Region: PRK06208 398527014444 intersubunit interface [polypeptide binding]; other site 398527014445 active site 398527014446 Zn2+ binding site [ion binding]; other site 398527014447 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 398527014448 Member of the Rhodanese Homology Domain superfamily, repeat 1. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 1st repeat which does not contain the putative...; Region: 4RHOD_Repeat_1; cd01532 398527014449 active site residue [active] 398527014450 Member of the Rhodanese Homology Domain superfamily, repeat 2. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 2nd repeat which does contain the putative catalytic...; Region: 4RHOD_Repeat_2; cd01533 398527014451 active site residue [active] 398527014452 Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534 398527014453 active site residue [active] 398527014454 Member of the Rhodanese Homology Domain superfamily, repeat 4. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 4th repeat which, in general, contains the putative...; Region: 4RHOD_Repeat_4; cd01535 398527014455 active site residue [active] 398527014456 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527014457 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527014458 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 398527014459 dimerization interface [polypeptide binding]; other site 398527014460 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 398527014461 membrane-bound complex binding site; other site 398527014462 hinge residues; other site 398527014463 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 398527014464 hypothetical protein; Provisional; Region: PRK10279 398527014465 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 398527014466 active site 398527014467 nucleophile elbow; other site 398527014468 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 398527014469 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527014470 dimer interface [polypeptide binding]; other site 398527014471 conserved gate region; other site 398527014472 putative PBP binding loops; other site 398527014473 ABC-ATPase subunit interface; other site 398527014474 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 398527014475 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527014476 dimer interface [polypeptide binding]; other site 398527014477 conserved gate region; other site 398527014478 putative PBP binding loops; other site 398527014479 ABC-ATPase subunit interface; other site 398527014480 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 398527014481 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 398527014482 Walker A/P-loop; other site 398527014483 ATP binding site [chemical binding]; other site 398527014484 Q-loop/lid; other site 398527014485 ABC transporter signature motif; other site 398527014486 Walker B; other site 398527014487 D-loop; other site 398527014488 H-loop/switch region; other site 398527014489 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 398527014490 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 398527014491 conserved cys residue [active] 398527014492 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527014493 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527014494 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 398527014495 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 398527014496 inhibitor-cofactor binding pocket; inhibition site 398527014497 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527014498 catalytic residue [active] 398527014499 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 398527014500 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 398527014501 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 398527014502 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 398527014503 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 398527014504 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 398527014505 NAD(P) binding site [chemical binding]; other site 398527014506 catalytic residues [active] 398527014507 succinylarginine dihydrolase; Provisional; Region: PRK13281 398527014508 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 398527014509 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 398527014510 putative active site [active] 398527014511 Zn binding site [ion binding]; other site 398527014512 glutathionine S-transferase; Provisional; Region: PRK10542 398527014513 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 398527014514 C-terminal domain interface [polypeptide binding]; other site 398527014515 GSH binding site (G-site) [chemical binding]; other site 398527014516 dimer interface [polypeptide binding]; other site 398527014517 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 398527014518 dimer interface [polypeptide binding]; other site 398527014519 N-terminal domain interface [polypeptide binding]; other site 398527014520 substrate binding pocket (H-site) [chemical binding]; other site 398527014521 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527014522 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527014523 LysR substrate binding domain; Region: LysR_substrate; pfam03466 398527014524 dimerization interface [polypeptide binding]; other site 398527014525 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 398527014526 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 398527014527 substrate binding pocket [chemical binding]; other site 398527014528 membrane-bound complex binding site; other site 398527014529 hinge residues; other site 398527014530 acetoacetate decarboxylase; Provisional; Region: PRK02265 398527014531 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 398527014532 EAL domain; Region: EAL; pfam00563 398527014533 HDOD domain; Region: HDOD; pfam08668 398527014534 PAS domain; Region: PAS_9; pfam13426 398527014535 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 398527014536 putative active site [active] 398527014537 heme pocket [chemical binding]; other site 398527014538 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 398527014539 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 398527014540 metal binding site [ion binding]; metal-binding site 398527014541 active site 398527014542 I-site; other site 398527014543 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 398527014544 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 398527014545 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 398527014546 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 398527014547 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 398527014548 catalytic triad [active] 398527014549 Transposase, Mutator family; Region: Transposase_mut; pfam00872 398527014550 MULE transposase domain; Region: MULE; pfam10551 398527014551 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 398527014552 Protein export membrane protein; Region: SecD_SecF; cl14618 398527014553 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 398527014554 Protein export membrane protein; Region: SecD_SecF; cl14618 398527014555 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 398527014556 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 398527014557 HlyD family secretion protein; Region: HlyD_3; pfam13437 398527014558 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 398527014559 Transcriptional regulator [Transcription]; Region: IclR; COG1414 398527014560 Bacterial transcriptional regulator; Region: IclR; pfam01614 398527014561 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 398527014562 Transposase; Region: HTH_Tnp_1; pfam01527 398527014563 putative transposase OrfB; Reviewed; Region: PHA02517 398527014564 HTH-like domain; Region: HTH_21; pfam13276 398527014565 Integrase core domain; Region: rve; pfam00665 398527014566 Integrase core domain; Region: rve_3; pfam13683 398527014567 photoactive yellow protein; Region: photo_yellow; TIGR02373 398527014568 PAS domain S-box; Region: sensory_box; TIGR00229 398527014569 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 398527014570 putative active site [active] 398527014571 heme pocket [chemical binding]; other site 398527014572 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 398527014573 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 398527014574 metal binding site [ion binding]; metal-binding site 398527014575 active site 398527014576 I-site; other site 398527014577 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 398527014578 muconolactone delta-isomerase; Region: muco_delta; TIGR03221 398527014579 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 398527014580 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 398527014581 octamer interface [polypeptide binding]; other site 398527014582 active site 398527014583 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 398527014584 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527014585 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in benzoate catabolism; contains the type 2 periplasmic binding fold; Region: PBP2_BenM_CatM_CatR; cd08445 398527014586 dimerizarion interface [polypeptide binding]; other site 398527014587 CrgA pocket; other site 398527014588 substrate binding pocket [chemical binding]; other site 398527014589 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 398527014590 Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460 398527014591 dimer interface [polypeptide binding]; other site 398527014592 active site 398527014593 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 398527014594 Rieske non-heme iron oxygenase (RO) family, 2-Halobenzoate 1,2-dioxygenase (HBDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_HBDO; cd03542 398527014595 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 398527014596 putative alpha subunit interface [polypeptide binding]; other site 398527014597 putative active site [active] 398527014598 putative substrate binding site [chemical binding]; other site 398527014599 Fe binding site [ion binding]; other site 398527014600 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 398527014601 inter-subunit interface; other site 398527014602 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 398527014603 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 398527014604 catalytic loop [active] 398527014605 iron binding site [ion binding]; other site 398527014606 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 398527014607 FAD binding pocket [chemical binding]; other site 398527014608 FAD binding motif [chemical binding]; other site 398527014609 phosphate binding motif [ion binding]; other site 398527014610 beta-alpha-beta structure motif; other site 398527014611 NAD binding pocket [chemical binding]; other site 398527014612 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 398527014613 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 398527014614 NAD(P) binding site [chemical binding]; other site 398527014615 active site 398527014616 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 398527014617 Coenzyme A transferase; Region: CoA_trans; smart00882 398527014618 Coenzyme A transferase; Region: CoA_trans; cl17247 398527014619 chromosome condensation membrane protein; Provisional; Region: PRK14196 398527014620 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 398527014621 CHASE3 domain; Region: CHASE3; pfam05227 398527014622 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 398527014623 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 398527014624 dimer interface [polypeptide binding]; other site 398527014625 phosphorylation site [posttranslational modification] 398527014626 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527014627 ATP binding site [chemical binding]; other site 398527014628 Mg2+ binding site [ion binding]; other site 398527014629 G-X-G motif; other site 398527014630 intracellular protease, PfpI family; Region: PfpI; TIGR01382 398527014631 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 398527014632 conserved cys residue [active] 398527014633 Predicted transcriptional regulator [Transcription]; Region: COG1959 398527014634 Transcriptional regulator; Region: Rrf2; pfam02082 398527014635 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 398527014636 NADH(P)-binding; Region: NAD_binding_10; pfam13460 398527014637 NAD binding site [chemical binding]; other site 398527014638 substrate binding site [chemical binding]; other site 398527014639 putative active site [active] 398527014640 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 398527014641 Mechanosensitive ion channel; Region: MS_channel; pfam00924 398527014642 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 398527014643 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 398527014644 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 398527014645 putative DNA binding site [nucleotide binding]; other site 398527014646 putative Zn2+ binding site [ion binding]; other site 398527014647 AsnC family; Region: AsnC_trans_reg; pfam01037 398527014648 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 398527014649 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 398527014650 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 398527014651 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 398527014652 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 398527014653 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 398527014654 Family description; Region: UvrD_C_2; pfam13538 398527014655 AAA domain; Region: AAA_30; pfam13604 398527014656 Family description; Region: UvrD_C_2; pfam13538 398527014657 hypothetical protein; Provisional; Region: PRK09256 398527014658 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 398527014659 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 398527014660 Uncharacterized conserved protein [Function unknown]; Region: COG1359 398527014661 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 398527014662 putative active site [active] 398527014663 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 398527014664 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527014665 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527014666 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 398527014667 putative dimerization interface [polypeptide binding]; other site 398527014668 aspartate aminotransferase; Provisional; Region: PRK06108 398527014669 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 398527014670 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527014671 homodimer interface [polypeptide binding]; other site 398527014672 catalytic residue [active] 398527014673 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 398527014674 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 398527014675 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 398527014676 RNA binding surface [nucleotide binding]; other site 398527014677 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 398527014678 probable active site [active] 398527014679 ribosome maturation protein RimP; Reviewed; Region: PRK00092 398527014680 Sm and related proteins; Region: Sm_like; cl00259 398527014681 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 398527014682 putative oligomer interface [polypeptide binding]; other site 398527014683 putative RNA binding site [nucleotide binding]; other site 398527014684 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 398527014685 NusA N-terminal domain; Region: NusA_N; pfam08529 398527014686 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 398527014687 RNA binding site [nucleotide binding]; other site 398527014688 homodimer interface [polypeptide binding]; other site 398527014689 NusA-like KH domain; Region: KH_5; pfam13184 398527014690 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 398527014691 G-X-X-G motif; other site 398527014692 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 398527014693 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 398527014694 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 398527014695 translation initiation factor IF-2; Region: IF-2; TIGR00487 398527014696 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 398527014697 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 398527014698 G1 box; other site 398527014699 putative GEF interaction site [polypeptide binding]; other site 398527014700 GTP/Mg2+ binding site [chemical binding]; other site 398527014701 Switch I region; other site 398527014702 G2 box; other site 398527014703 G3 box; other site 398527014704 Switch II region; other site 398527014705 G4 box; other site 398527014706 G5 box; other site 398527014707 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 398527014708 Translation-initiation factor 2; Region: IF-2; pfam11987 398527014709 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 398527014710 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 398527014711 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01851 398527014712 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 398527014713 RNA binding site [nucleotide binding]; other site 398527014714 active site 398527014715 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 398527014716 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 398527014717 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527014718 putative substrate translocation pore; other site 398527014719 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527014720 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 398527014721 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 398527014722 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 398527014723 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 398527014724 Transcriptional regulators [Transcription]; Region: MarR; COG1846 398527014725 MarR family; Region: MarR_2; pfam12802 398527014726 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 398527014727 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 398527014728 G1 box; other site 398527014729 putative GEF interaction site [polypeptide binding]; other site 398527014730 GTP/Mg2+ binding site [chemical binding]; other site 398527014731 Switch I region; other site 398527014732 G2 box; other site 398527014733 G3 box; other site 398527014734 Switch II region; other site 398527014735 G4 box; other site 398527014736 G5 box; other site 398527014737 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 398527014738 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 398527014739 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 398527014740 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 398527014741 TPP-binding site [chemical binding]; other site 398527014742 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 398527014743 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 398527014744 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 398527014745 E3 interaction surface; other site 398527014746 lipoyl attachment site [posttranslational modification]; other site 398527014747 e3 binding domain; Region: E3_binding; pfam02817 398527014748 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 398527014749 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 398527014750 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 398527014751 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 398527014752 Predicted ATPase [General function prediction only]; Region: COG1485 398527014753 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 398527014754 Walker B; other site 398527014755 D-loop; other site 398527014756 H-loop/switch region; other site 398527014757 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 398527014758 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 398527014759 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 398527014760 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 398527014761 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 398527014762 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 398527014763 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 398527014764 TadE-like protein; Region: TadE; pfam07811 398527014765 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 398527014766 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 398527014767 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 398527014768 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 398527014769 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 398527014770 AAA domain; Region: AAA_31; pfam13614 398527014771 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 398527014772 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 398527014773 ATP binding site [chemical binding]; other site 398527014774 Walker A motif; other site 398527014775 hexamer interface [polypeptide binding]; other site 398527014776 Walker B motif; other site 398527014777 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 398527014778 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 398527014779 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 398527014780 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 398527014781 Protein of unknown function (DUF3613); Region: DUF3613; pfam12266 398527014782 Predicted membrane protein [Function unknown]; Region: COG4655 398527014783 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 398527014784 Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977 398527014785 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 398527014786 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527014787 Walker A motif; other site 398527014788 ATP binding site [chemical binding]; other site 398527014789 Walker B motif; other site 398527014790 arginine finger; other site 398527014791 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 398527014792 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 398527014793 bacterial Hfq-like; Region: Hfq; cd01716 398527014794 hexamer interface [polypeptide binding]; other site 398527014795 Sm1 motif; other site 398527014796 RNA binding site [nucleotide binding]; other site 398527014797 Sm2 motif; other site 398527014798 RNA polymerase sigma factor; Provisional; Region: PRK12511 398527014799 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 398527014800 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 398527014801 DNA binding residues [nucleotide binding] 398527014802 Putative zinc-finger; Region: zf-HC2; pfam13490 398527014803 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 398527014804 Pleckstrin homology-like domain; Region: PH-like; cl17171 398527014805 DNA binding domains of BfiI, EcoRII and plant B3 proteins; Region: BfiI_C_EcoRII_N_B3; cl15242 398527014806 DNA binding site [nucleotide binding] 398527014807 Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520 398527014808 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 398527014809 FAD binding domain; Region: FAD_binding_4; pfam01565 398527014810 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 398527014811 Protein of unknown function (DUF1571); Region: DUF1571; pfam07608 398527014812 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 398527014813 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 398527014814 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 398527014815 acyl-activating enzyme (AAE) consensus motif; other site 398527014816 putative AMP binding site [chemical binding]; other site 398527014817 putative active site [active] 398527014818 putative CoA binding site [chemical binding]; other site 398527014819 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 398527014820 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 398527014821 dimer interface [polypeptide binding]; other site 398527014822 active site 398527014823 enoyl-CoA hydratase; Region: PLN02864 398527014824 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 398527014825 active site 2 [active] 398527014826 active site 1 [active] 398527014827 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 398527014828 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 398527014829 NAD(P) binding site [chemical binding]; other site 398527014830 active site 398527014831 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 398527014832 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 398527014833 active site 398527014834 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 398527014835 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 398527014836 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 398527014837 putative sialic acid transporter; Region: 2A0112; TIGR00891 398527014838 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527014839 putative substrate translocation pore; other site 398527014840 MAPEG family; Region: MAPEG; cl09190 398527014841 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 398527014842 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 398527014843 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 398527014844 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 398527014845 putative ion selectivity filter; other site 398527014846 putative pore gating glutamate residue; other site 398527014847 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 398527014848 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 398527014849 Trp docking motif [polypeptide binding]; other site 398527014850 putative active site [active] 398527014851 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 398527014852 Catalytic domain of Protein Kinases; Region: PKc; cd00180 398527014853 substrate binding site [chemical binding]; other site 398527014854 activation loop (A-loop); other site 398527014855 AAA ATPase domain; Region: AAA_16; pfam13191 398527014856 Predicted ATPase [General function prediction only]; Region: COG3899 398527014857 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 398527014858 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 398527014859 PAS domain S-box; Region: sensory_box; TIGR00229 398527014860 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 398527014861 putative active site [active] 398527014862 heme pocket [chemical binding]; other site 398527014863 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 398527014864 dimer interface [polypeptide binding]; other site 398527014865 phosphorylation site [posttranslational modification] 398527014866 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527014867 ATP binding site [chemical binding]; other site 398527014868 Mg2+ binding site [ion binding]; other site 398527014869 G-X-G motif; other site 398527014870 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 398527014871 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527014872 active site 398527014873 phosphorylation site [posttranslational modification] 398527014874 intermolecular recognition site; other site 398527014875 dimerization interface [polypeptide binding]; other site 398527014876 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 398527014877 DNA binding residues [nucleotide binding] 398527014878 dimerization interface [polypeptide binding]; other site 398527014879 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 398527014880 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 398527014881 catalytic residues [active] 398527014882 Domain of unknown function (DUF3331); Region: DUF3331; pfam11811 398527014883 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527014884 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527014885 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 398527014886 putative effector binding pocket; other site 398527014887 dimerization interface [polypeptide binding]; other site 398527014888 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 398527014889 classical (c) SDRs; Region: SDR_c; cd05233 398527014890 NAD(P) binding site [chemical binding]; other site 398527014891 active site 398527014892 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 398527014893 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 398527014894 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 398527014895 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 398527014896 substrate binding site [chemical binding]; other site 398527014897 oxyanion hole (OAH) forming residues; other site 398527014898 trimer interface [polypeptide binding]; other site 398527014899 Epoxide hydrolase N terminus; Region: EHN; pfam06441 398527014900 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 398527014901 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 398527014902 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 398527014903 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 398527014904 HlyD family secretion protein; Region: HlyD_3; pfam13437 398527014905 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 398527014906 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527014907 putative substrate translocation pore; other site 398527014908 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 398527014909 active site 398527014910 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 398527014911 catalytic tetrad [active] 398527014912 Response regulator receiver domain; Region: Response_reg; pfam00072 398527014913 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527014914 active site 398527014915 phosphorylation site [posttranslational modification] 398527014916 intermolecular recognition site; other site 398527014917 dimerization interface [polypeptide binding]; other site 398527014918 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 398527014919 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 398527014920 ribonuclease R; Region: RNase_R; TIGR02063 398527014921 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 398527014922 RNB domain; Region: RNB; pfam00773 398527014923 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 398527014924 RNA binding site [nucleotide binding]; other site 398527014925 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 398527014926 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 398527014927 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 398527014928 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 398527014929 tetramer (dimer of dimers) interface [polypeptide binding]; other site 398527014930 active site 398527014931 dimer interface [polypeptide binding]; other site 398527014932 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 398527014933 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 398527014934 putative ADP-binding pocket [chemical binding]; other site 398527014935 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 398527014936 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 398527014937 non-specific DNA binding site [nucleotide binding]; other site 398527014938 salt bridge; other site 398527014939 sequence-specific DNA binding site [nucleotide binding]; other site 398527014940 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 398527014941 Bacterial sugar transferase; Region: Bac_transf; pfam02397 398527014942 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 398527014943 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 398527014944 ligand binding site [chemical binding]; other site 398527014945 flexible hinge region; other site 398527014946 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 398527014947 non-specific DNA interactions [nucleotide binding]; other site 398527014948 DNA binding site [nucleotide binding] 398527014949 sequence specific DNA binding site [nucleotide binding]; other site 398527014950 putative cAMP binding site [chemical binding]; other site 398527014951 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 398527014952 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 398527014953 Domain of unknown function (DUF1839); Region: DUF1839; pfam08893 398527014954 Gly_His_Pro_Ser_Thr_tRNA synthetase class II core domain. This domain is the core catalytic domain of tRNA synthetases of the subgroup containing glycyl, histidyl, prolyl, seryl and threonyl tRNA synthetases. It is primarily responsible for ATP-dependent...; Region: Gly_His_Pro_Ser_Thr_tRS_core; cd00670 398527014955 motif 1; other site 398527014956 dimer interface [polypeptide binding]; other site 398527014957 active site 398527014958 motif 2; other site 398527014959 motif 3; other site 398527014960 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 398527014961 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 398527014962 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 398527014963 acyl carrier protein; Provisional; Region: PRK07081 398527014964 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 398527014965 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 398527014966 S-adenosylmethionine binding site [chemical binding]; other site 398527014967 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 398527014968 active site 398527014969 Cupin domain; Region: Cupin_2; cl17218 398527014970 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 398527014971 Transcriptional regulators [Transcription]; Region: FadR; COG2186 398527014972 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527014973 DNA-binding site [nucleotide binding]; DNA binding site 398527014974 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 398527014975 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 398527014976 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 398527014977 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 398527014978 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 398527014979 Catalytic site [active] 398527014980 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 398527014981 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 398527014982 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527014983 dimer interface [polypeptide binding]; other site 398527014984 conserved gate region; other site 398527014985 putative PBP binding loops; other site 398527014986 ABC-ATPase subunit interface; other site 398527014987 cystine transporter subunit; Provisional; Region: PRK11260 398527014988 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 398527014989 substrate binding pocket [chemical binding]; other site 398527014990 membrane-bound complex binding site; other site 398527014991 hinge residues; other site 398527014992 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 398527014993 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 398527014994 quinone interaction residues [chemical binding]; other site 398527014995 active site 398527014996 catalytic residues [active] 398527014997 FMN binding site [chemical binding]; other site 398527014998 substrate binding site [chemical binding]; other site 398527014999 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 398527015000 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 398527015001 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 398527015002 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 398527015003 Ribosomal protein S27a; Region: Ribosomal_S27; cl00876 398527015004 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_4; cd04511 398527015005 nudix motif; other site 398527015006 hypothetical protein; Provisional; Region: PRK02487 398527015007 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 398527015008 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 398527015009 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 398527015010 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 398527015011 NAD(P) binding site [chemical binding]; other site 398527015012 active site 398527015013 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 398527015014 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 398527015015 WHG domain; Region: WHG; pfam13305 398527015016 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 398527015017 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 398527015018 substrate binding site [chemical binding]; other site 398527015019 oxyanion hole (OAH) forming residues; other site 398527015020 trimer interface [polypeptide binding]; other site 398527015021 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 398527015022 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 398527015023 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 398527015024 active site 398527015025 dimer interface [polypeptide binding]; other site 398527015026 non-prolyl cis peptide bond; other site 398527015027 insertion regions; other site 398527015028 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 398527015029 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527015030 dimer interface [polypeptide binding]; other site 398527015031 conserved gate region; other site 398527015032 putative PBP binding loops; other site 398527015033 ABC-ATPase subunit interface; other site 398527015034 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 398527015035 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 398527015036 Walker A/P-loop; other site 398527015037 ATP binding site [chemical binding]; other site 398527015038 Q-loop/lid; other site 398527015039 ABC transporter signature motif; other site 398527015040 Walker B; other site 398527015041 D-loop; other site 398527015042 H-loop/switch region; other site 398527015043 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 398527015044 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 398527015045 dimer interface [polypeptide binding]; other site 398527015046 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 398527015047 ligand binding site [chemical binding]; other site 398527015048 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 398527015049 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 398527015050 FMN binding site [chemical binding]; other site 398527015051 active site 398527015052 catalytic residues [active] 398527015053 substrate binding site [chemical binding]; other site 398527015054 TPR repeat; Region: TPR_11; pfam13414 398527015055 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 398527015056 TPR motif; other site 398527015057 binding surface 398527015058 TPR repeat; Region: TPR_11; pfam13414 398527015059 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 398527015060 binding surface 398527015061 TPR motif; other site 398527015062 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 398527015063 AAA domain; Region: AAA_18; pfam13238 398527015064 ligand-binding site [chemical binding]; other site 398527015065 UPF0126 domain; Region: UPF0126; pfam03458 398527015066 Predicted membrane protein [Function unknown]; Region: COG2860 398527015067 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 398527015068 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 398527015069 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 398527015070 active site 398527015071 catalytic tetrad [active] 398527015072 citrate-proton symporter; Provisional; Region: PRK15075 398527015073 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527015074 putative substrate translocation pore; other site 398527015075 hypothetical protein; Provisional; Region: PRK07079 398527015076 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679 398527015077 metal binding site [ion binding]; metal-binding site 398527015078 putative dimer interface [polypeptide binding]; other site 398527015079 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527015080 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527015081 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 398527015082 dimerization interface [polypeptide binding]; other site 398527015083 ABC-2 type transporter; Region: ABC2_membrane; cl17235 398527015084 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 398527015085 nodulation ABC transporter NodI; Provisional; Region: PRK13537 398527015086 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 398527015087 Walker A/P-loop; other site 398527015088 ATP binding site [chemical binding]; other site 398527015089 Q-loop/lid; other site 398527015090 ABC transporter signature motif; other site 398527015091 Walker B; other site 398527015092 D-loop; other site 398527015093 H-loop/switch region; other site 398527015094 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 398527015095 Ligand Binding Site [chemical binding]; other site 398527015096 Protein of unknown function (DUF2939); Region: DUF2939; pfam11159 398527015097 LexA repressor; Validated; Region: PRK00215 398527015098 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 398527015099 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 398527015100 Catalytic site [active] 398527015101 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 398527015102 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 398527015103 substrate binding pocket [chemical binding]; other site 398527015104 membrane-bound complex binding site; other site 398527015105 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 398527015106 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527015107 dimer interface [polypeptide binding]; other site 398527015108 conserved gate region; other site 398527015109 putative PBP binding loops; other site 398527015110 ABC-ATPase subunit interface; other site 398527015111 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527015112 dimer interface [polypeptide binding]; other site 398527015113 conserved gate region; other site 398527015114 putative PBP binding loops; other site 398527015115 ABC-ATPase subunit interface; other site 398527015116 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 398527015117 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 398527015118 Walker A/P-loop; other site 398527015119 ATP binding site [chemical binding]; other site 398527015120 Q-loop/lid; other site 398527015121 ABC transporter signature motif; other site 398527015122 Walker B; other site 398527015123 D-loop; other site 398527015124 H-loop/switch region; other site 398527015125 TOBE-like domain; Region: TOBE_3; pfam12857 398527015126 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12683 398527015127 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527015128 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 398527015129 substrate binding site [chemical binding]; other site 398527015130 dimerization interface [polypeptide binding]; other site 398527015131 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 398527015132 active site 398527015133 homodimer interface [polypeptide binding]; other site 398527015134 homotetramer interface [polypeptide binding]; other site 398527015135 Domain of unknown function (DUF3597); Region: DUF3597; pfam12200 398527015136 tartronate semialdehyde reductase; Provisional; Region: PRK15059 398527015137 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 398527015138 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 398527015139 glyoxylate carboligase; Provisional; Region: PRK11269 398527015140 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 398527015141 PYR/PP interface [polypeptide binding]; other site 398527015142 dimer interface [polypeptide binding]; other site 398527015143 TPP binding site [chemical binding]; other site 398527015144 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 398527015145 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 398527015146 TPP-binding site [chemical binding]; other site 398527015147 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527015148 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527015149 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 398527015150 putative effector binding pocket; other site 398527015151 dimerization interface [polypeptide binding]; other site 398527015152 RNA polymerase sigma factor; Provisional; Region: PRK12533 398527015153 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 398527015154 Putative zinc-finger; Region: zf-HC2; pfam13490 398527015155 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 398527015156 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 398527015157 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 398527015158 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 398527015159 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 398527015160 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 398527015161 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 398527015162 replicative DNA helicase; Provisional; Region: PRK07004 398527015163 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 398527015164 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 398527015165 Walker A motif; other site 398527015166 ATP binding site [chemical binding]; other site 398527015167 Walker B motif; other site 398527015168 DNA binding loops [nucleotide binding] 398527015169 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 398527015170 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 398527015171 short chain dehydrogenase; Provisional; Region: PRK06125 398527015172 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 398527015173 NAD(P) binding site [chemical binding]; other site 398527015174 active site 398527015175 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 398527015176 NlpC/P60 family; Region: NLPC_P60; pfam00877 398527015177 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 398527015178 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 398527015179 putative active site [active] 398527015180 PhoH-like protein; Region: PhoH; pfam02562 398527015181 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 398527015182 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 398527015183 catalytic triad [active] 398527015184 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 398527015185 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 398527015186 putative active site [active] 398527015187 putative catalytic site [active] 398527015188 putative Zn binding site [ion binding]; other site 398527015189 NAD-dependent epimerase/dehydratase family protein; Provisional; Region: PRK11908 398527015190 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 398527015191 NAD binding site [chemical binding]; other site 398527015192 substrate binding site [chemical binding]; other site 398527015193 active site 398527015194 putative formyltransferase; Provisional; Region: PRK06988 398527015195 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 398527015196 active site 398527015197 substrate binding site [chemical binding]; other site 398527015198 cosubstrate binding site; other site 398527015199 catalytic site [active] 398527015200 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 398527015201 active site 398527015202 hexamer interface [polypeptide binding]; other site 398527015203 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 398527015204 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 398527015205 Ligand binding site; other site 398527015206 Putative Catalytic site; other site 398527015207 DXD motif; other site 398527015208 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 398527015209 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 398527015210 inhibitor-cofactor binding pocket; inhibition site 398527015211 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527015212 catalytic residue [active] 398527015213 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 398527015214 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 398527015215 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 398527015216 Xcc1710_like family, specific to proteobacteria. Xcc1710 is a hypothetical protein from Xanthomonas campestris pv. campestris str. ATCC 33913, similar to Mth938, a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome; Region: Xcc1710_like; cd05560 398527015217 aminotransferase AlaT; Validated; Region: PRK09265 398527015218 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 398527015219 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527015220 homodimer interface [polypeptide binding]; other site 398527015221 catalytic residue [active] 398527015222 homoserine dehydrogenase; Provisional; Region: PRK06349 398527015223 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 398527015224 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 398527015225 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 398527015226 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 398527015227 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 398527015228 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527015229 catalytic residue [active] 398527015230 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 398527015231 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 398527015232 dimer interface [polypeptide binding]; other site 398527015233 putative functional site; other site 398527015234 putative MPT binding site; other site 398527015235 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 398527015236 MoaE interaction surface [polypeptide binding]; other site 398527015237 MoeB interaction surface [polypeptide binding]; other site 398527015238 thiocarboxylated glycine; other site 398527015239 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 398527015240 MoaE homodimer interface [polypeptide binding]; other site 398527015241 MoaD interaction [polypeptide binding]; other site 398527015242 active site residues [active] 398527015243 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 398527015244 apolar tunnel; other site 398527015245 heme binding site [chemical binding]; other site 398527015246 dimerization interface [polypeptide binding]; other site 398527015247 Transcriptional regulator; Region: Rrf2; cl17282 398527015248 Rrf2 family protein; Region: rrf2_super; TIGR00738 398527015249 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 398527015250 Clp amino terminal domain; Region: Clp_N; pfam02861 398527015251 Clp amino terminal domain; Region: Clp_N; pfam02861 398527015252 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527015253 Walker A motif; other site 398527015254 ATP binding site [chemical binding]; other site 398527015255 Walker B motif; other site 398527015256 arginine finger; other site 398527015257 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527015258 Walker A motif; other site 398527015259 ATP binding site [chemical binding]; other site 398527015260 Walker B motif; other site 398527015261 arginine finger; other site 398527015262 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 398527015263 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 398527015264 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 398527015265 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 398527015266 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 398527015267 DNA binding residues [nucleotide binding] 398527015268 putative dimer interface [polypeptide binding]; other site 398527015269 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 398527015270 multidrug efflux protein; Reviewed; Region: PRK01766 398527015271 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 398527015272 cation binding site [ion binding]; other site 398527015273 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 398527015274 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 398527015275 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167 398527015276 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527015277 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 398527015278 putative substrate translocation pore; other site 398527015279 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 398527015280 Helix-Turn-Helix DNA binding domain of the YfmP transcription regulator; Region: HTH_YfmP; cd04774 398527015281 DNA binding residues [nucleotide binding] 398527015282 putative dimer interface [polypeptide binding]; other site 398527015283 transcription termination factor Rho; Provisional; Region: rho; PRK09376 398527015284 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 398527015285 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 398527015286 RNA binding site [nucleotide binding]; other site 398527015287 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 398527015288 multimer interface [polypeptide binding]; other site 398527015289 Walker A motif; other site 398527015290 ATP binding site [chemical binding]; other site 398527015291 Walker B motif; other site 398527015292 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 398527015293 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 398527015294 catalytic residues [active] 398527015295 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 398527015296 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527015297 Walker A motif; other site 398527015298 ATP binding site [chemical binding]; other site 398527015299 Walker B motif; other site 398527015300 arginine finger; other site 398527015301 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 398527015302 hypothetical protein; Validated; Region: PRK00153 398527015303 recombination protein RecR; Reviewed; Region: recR; PRK00076 398527015304 RecR protein; Region: RecR; pfam02132 398527015305 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 398527015306 putative active site [active] 398527015307 putative metal-binding site [ion binding]; other site 398527015308 tetramer interface [polypeptide binding]; other site 398527015309 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 398527015310 CoA-transferase family III; Region: CoA_transf_3; pfam02515 398527015311 NMT1-like family; Region: NMT1_2; pfam13379 398527015312 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 398527015313 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 398527015314 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 398527015315 Walker A/P-loop; other site 398527015316 ATP binding site [chemical binding]; other site 398527015317 Q-loop/lid; other site 398527015318 ABC transporter signature motif; other site 398527015319 Walker B; other site 398527015320 D-loop; other site 398527015321 H-loop/switch region; other site 398527015322 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 398527015323 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527015324 dimer interface [polypeptide binding]; other site 398527015325 conserved gate region; other site 398527015326 putative PBP binding loops; other site 398527015327 ABC-ATPase subunit interface; other site 398527015328 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 398527015329 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 398527015330 NAD(P) binding site [chemical binding]; other site 398527015331 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 398527015332 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 398527015333 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 398527015334 S-adenosylmethionine binding site [chemical binding]; other site 398527015335 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 398527015336 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 398527015337 Peptidase family M23; Region: Peptidase_M23; pfam01551 398527015338 RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394 398527015339 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 398527015340 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 398527015341 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 398527015342 DNA binding residues [nucleotide binding] 398527015343 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 398527015344 active site 398527015345 catalytic site [active] 398527015346 substrate binding site [chemical binding]; other site 398527015347 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 398527015348 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 398527015349 TRAM domain; Region: TRAM; cl01282 398527015350 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 398527015351 S-adenosylmethionine binding site [chemical binding]; other site 398527015352 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 398527015353 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 398527015354 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 398527015355 RNA binding surface [nucleotide binding]; other site 398527015356 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 398527015357 active site 398527015358 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 398527015359 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 398527015360 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 398527015361 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 398527015362 putative acyltransferase; Provisional; Region: PRK05790 398527015363 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 398527015364 dimer interface [polypeptide binding]; other site 398527015365 active site 398527015366 acetyacetyl-CoA reductase; Provisional; Region: PRK12938 398527015367 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 398527015368 NAD(P) binding site [chemical binding]; other site 398527015369 homotetramer interface [polypeptide binding]; other site 398527015370 homodimer interface [polypeptide binding]; other site 398527015371 active site 398527015372 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5394 398527015373 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 398527015374 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 398527015375 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 398527015376 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 398527015377 FMN binding site [chemical binding]; other site 398527015378 active site 398527015379 catalytic residues [active] 398527015380 substrate binding site [chemical binding]; other site 398527015381 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 398527015382 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 398527015383 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 398527015384 FeS/SAM binding site; other site 398527015385 TRAM domain; Region: TRAM; cl01282 398527015386 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 398527015387 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 398527015388 substrate binding site [chemical binding]; other site 398527015389 ATP binding site [chemical binding]; other site 398527015390 beta-ketothiolase; Provisional; Region: PRK09051 398527015391 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 398527015392 dimer interface [polypeptide binding]; other site 398527015393 active site 398527015394 cystathionine beta-lyase; Provisional; Region: PRK07050 398527015395 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 398527015396 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 398527015397 catalytic residue [active] 398527015398 Domain of unknown function (DUF4072); Region: DUF4072; pfam13284 398527015399 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 398527015400 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 398527015401 motif II; other site 398527015402 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 398527015403 Cytochrome P450; Region: p450; cl12078 398527015404 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 398527015405 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 398527015406 putative DNA binding site [nucleotide binding]; other site 398527015407 putative homodimer interface [polypeptide binding]; other site 398527015408 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK05972 398527015409 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 398527015410 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 398527015411 active site 398527015412 DNA binding site [nucleotide binding] 398527015413 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 398527015414 DNA binding site [nucleotide binding] 398527015415 PaeLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: PaeLigD_Pol_like; cd04862 398527015416 nucleotide binding site [chemical binding]; other site 398527015417 transcriptional activator TtdR; Provisional; Region: PRK09801 398527015418 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527015419 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 398527015420 putative effector binding pocket; other site 398527015421 dimerization interface [polypeptide binding]; other site 398527015422 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 398527015423 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 398527015424 putative NAD(P) binding site [chemical binding]; other site 398527015425 dimer interface [polypeptide binding]; other site 398527015426 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 398527015427 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 398527015428 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 398527015429 Walker A/P-loop; other site 398527015430 ATP binding site [chemical binding]; other site 398527015431 Q-loop/lid; other site 398527015432 ABC transporter signature motif; other site 398527015433 Walker B; other site 398527015434 D-loop; other site 398527015435 H-loop/switch region; other site 398527015436 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 398527015437 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 398527015438 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 398527015439 HAMP domain; Region: HAMP; pfam00672 398527015440 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 398527015441 dimer interface [polypeptide binding]; other site 398527015442 phosphorylation site [posttranslational modification] 398527015443 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527015444 ATP binding site [chemical binding]; other site 398527015445 Mg2+ binding site [ion binding]; other site 398527015446 G-X-G motif; other site 398527015447 Response regulator receiver domain; Region: Response_reg; pfam00072 398527015448 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527015449 active site 398527015450 phosphorylation site [posttranslational modification] 398527015451 intermolecular recognition site; other site 398527015452 dimerization interface [polypeptide binding]; other site 398527015453 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 398527015454 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527015455 active site 398527015456 phosphorylation site [posttranslational modification] 398527015457 intermolecular recognition site; other site 398527015458 dimerization interface [polypeptide binding]; other site 398527015459 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 398527015460 PAS fold; Region: PAS_3; pfam08447 398527015461 putative active site [active] 398527015462 heme pocket [chemical binding]; other site 398527015463 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 398527015464 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 398527015465 dimer interface [polypeptide binding]; other site 398527015466 phosphorylation site [posttranslational modification] 398527015467 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527015468 ATP binding site [chemical binding]; other site 398527015469 Mg2+ binding site [ion binding]; other site 398527015470 G-X-G motif; other site 398527015471 Response regulator receiver domain; Region: Response_reg; pfam00072 398527015472 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527015473 active site 398527015474 phosphorylation site [posttranslational modification] 398527015475 intermolecular recognition site; other site 398527015476 dimerization interface [polypeptide binding]; other site 398527015477 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 398527015478 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 398527015479 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 398527015480 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 398527015481 tetramer interface [polypeptide binding]; other site 398527015482 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527015483 catalytic residue [active] 398527015484 acetylornithine deacetylase; Provisional; Region: PRK07522 398527015485 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 398527015486 metal binding site [ion binding]; metal-binding site 398527015487 putative dimer interface [polypeptide binding]; other site 398527015488 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 398527015489 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 398527015490 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 398527015491 ATP binding site [chemical binding]; other site 398527015492 putative Mg++ binding site [ion binding]; other site 398527015493 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 398527015494 nucleotide binding region [chemical binding]; other site 398527015495 ATP-binding site [chemical binding]; other site 398527015496 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 398527015497 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 398527015498 substrate binding site; other site 398527015499 dimer interface; other site 398527015500 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 398527015501 homotrimer interaction site [polypeptide binding]; other site 398527015502 zinc binding site [ion binding]; other site 398527015503 CDP-binding sites; other site 398527015504 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 398527015505 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 398527015506 dimer interface [polypeptide binding]; other site 398527015507 decamer (pentamer of dimers) interface [polypeptide binding]; other site 398527015508 catalytic triad [active] 398527015509 peroxidatic and resolving cysteines [active] 398527015510 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 398527015511 dimerization interface [polypeptide binding]; other site 398527015512 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 398527015513 dimer interface [polypeptide binding]; other site 398527015514 phosphorylation site [posttranslational modification] 398527015515 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527015516 ATP binding site [chemical binding]; other site 398527015517 Mg2+ binding site [ion binding]; other site 398527015518 G-X-G motif; other site 398527015519 osmolarity response regulator; Provisional; Region: ompR; PRK09468 398527015520 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527015521 active site 398527015522 phosphorylation site [posttranslational modification] 398527015523 intermolecular recognition site; other site 398527015524 dimerization interface [polypeptide binding]; other site 398527015525 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 398527015526 DNA binding site [nucleotide binding] 398527015527 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5267 398527015528 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 398527015529 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 398527015530 active site lid residues [active] 398527015531 substrate binding pocket [chemical binding]; other site 398527015532 catalytic residues [active] 398527015533 substrate-Mg2+ binding site; other site 398527015534 aspartate-rich region 1; other site 398527015535 aspartate-rich region 2; other site 398527015536 Ureidoglycolate hydrolase; Region: Ureidogly_hydro; cl01250 398527015537 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 398527015538 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 398527015539 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 398527015540 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 398527015541 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 398527015542 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527015543 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 398527015544 putative substrate binding pocket [chemical binding]; other site 398527015545 putative dimerization interface [polypeptide binding]; other site 398527015546 C factor cell-cell signaling protein; Provisional; Region: PRK09009 398527015547 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 398527015548 NADP binding site [chemical binding]; other site 398527015549 homodimer interface [polypeptide binding]; other site 398527015550 active site 398527015551 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 398527015552 homotrimer interaction site [polypeptide binding]; other site 398527015553 putative active site [active] 398527015554 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 398527015555 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 398527015556 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 398527015557 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 398527015558 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 398527015559 hydroxyglutarate oxidase; Provisional; Region: PRK11728 398527015560 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 398527015561 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527015562 dimer interface [polypeptide binding]; other site 398527015563 conserved gate region; other site 398527015564 putative PBP binding loops; other site 398527015565 ABC-ATPase subunit interface; other site 398527015566 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527015567 dimer interface [polypeptide binding]; other site 398527015568 conserved gate region; other site 398527015569 putative PBP binding loops; other site 398527015570 ABC-ATPase subunit interface; other site 398527015571 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 398527015572 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 398527015573 Walker A/P-loop; other site 398527015574 ATP binding site [chemical binding]; other site 398527015575 Q-loop/lid; other site 398527015576 ABC transporter signature motif; other site 398527015577 Walker B; other site 398527015578 D-loop; other site 398527015579 H-loop/switch region; other site 398527015580 TOBE domain; Region: TOBE_2; pfam08402 398527015581 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 398527015582 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 398527015583 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 398527015584 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527015585 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 398527015586 dimerization interface [polypeptide binding]; other site 398527015587 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 398527015588 putative hydrolase; Provisional; Region: PRK11460 398527015589 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 398527015590 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 398527015591 Protein of unknown function (DUF3999); Region: DUF3999; pfam13163 398527015592 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 398527015593 MarR family; Region: MarR_2; pfam12802 398527015594 MarR family; Region: MarR_2; cl17246 398527015595 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 398527015596 trigger factor; Provisional; Region: tig; PRK01490 398527015597 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 398527015598 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 398527015599 Clp protease; Region: CLP_protease; pfam00574 398527015600 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 398527015601 oligomer interface [polypeptide binding]; other site 398527015602 active site residues [active] 398527015603 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 398527015604 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 398527015605 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527015606 Walker A motif; other site 398527015607 ATP binding site [chemical binding]; other site 398527015608 Walker B motif; other site 398527015609 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 398527015610 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 398527015611 Found in ATP-dependent protease La (LON); Region: LON; smart00464 398527015612 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527015613 Walker A motif; other site 398527015614 ATP binding site [chemical binding]; other site 398527015615 Walker B motif; other site 398527015616 arginine finger; other site 398527015617 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 398527015618 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 398527015619 IHF dimer interface [polypeptide binding]; other site 398527015620 IHF - DNA interface [nucleotide binding]; other site 398527015621 SurA N-terminal domain; Region: SurA_N_3; cl07813 398527015622 periplasmic folding chaperone; Provisional; Region: PRK10788 398527015623 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 398527015624 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 398527015625 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 398527015626 active site 398527015627 catalytic triad [active] 398527015628 oxyanion hole [active] 398527015629 switch loop; other site 398527015630 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 398527015631 Q-loop/lid; other site 398527015632 ABC transporter signature motif; other site 398527015633 Walker B; other site 398527015634 D-loop; other site 398527015635 H-loop/switch region; other site 398527015636 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 398527015637 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 398527015638 active site 398527015639 dimer interface [polypeptide binding]; other site 398527015640 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 398527015641 dimer interface [polypeptide binding]; other site 398527015642 active site 398527015643 putative carbohydrate kinase; Provisional; Region: PRK10565 398527015644 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 398527015645 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 398527015646 putative substrate binding site [chemical binding]; other site 398527015647 putative ATP binding site [chemical binding]; other site 398527015648 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 398527015649 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 398527015650 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 398527015651 dimerization interface [polypeptide binding]; other site 398527015652 ATP binding site [chemical binding]; other site 398527015653 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 398527015654 dimerization interface [polypeptide binding]; other site 398527015655 ATP binding site [chemical binding]; other site 398527015656 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 398527015657 putative active site [active] 398527015658 catalytic triad [active] 398527015659 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 398527015660 non-specific DNA binding site [nucleotide binding]; other site 398527015661 salt bridge; other site 398527015662 sequence-specific DNA binding site [nucleotide binding]; other site 398527015663 HipA N-terminal domain; Region: Couple_hipA; pfam13657 398527015664 HipA-like N-terminal domain; Region: HipA_N; pfam07805 398527015665 HipA-like C-terminal domain; Region: HipA_C; pfam07804 398527015666 SurA N-terminal domain; Region: SurA_N_3; cl07813 398527015667 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 398527015668 BolA-like protein; Region: BolA; pfam01722 398527015669 intracellular septation protein A; Reviewed; Region: PRK00259 398527015670 methionine sulfoxide reductase B; Provisional; Region: PRK00222 398527015671 SelR domain; Region: SelR; pfam01641 398527015672 Uncharacterized conserved protein [Function unknown]; Region: COG0397 398527015673 hypothetical protein; Validated; Region: PRK00029 398527015674 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 398527015675 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 398527015676 dimer interface [polypeptide binding]; other site 398527015677 acyl-activating enzyme (AAE) consensus motif; other site 398527015678 putative active site [active] 398527015679 AMP binding site [chemical binding]; other site 398527015680 putative CoA binding site [chemical binding]; other site 398527015681 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 398527015682 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 398527015683 substrate binding site [chemical binding]; other site 398527015684 oxyanion hole (OAH) forming residues; other site 398527015685 trimer interface [polypeptide binding]; other site 398527015686 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 398527015687 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 398527015688 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 398527015689 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 398527015690 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 398527015691 dimer interface [polypeptide binding]; other site 398527015692 active site 398527015693 Water Stress and Hypersensitive response; Region: WHy; smart00769 398527015694 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 398527015695 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527015696 DNA-binding site [nucleotide binding]; DNA binding site 398527015697 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 398527015698 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527015699 homodimer interface [polypeptide binding]; other site 398527015700 catalytic residue [active] 398527015701 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 398527015702 CoenzymeA binding site [chemical binding]; other site 398527015703 subunit interaction site [polypeptide binding]; other site 398527015704 PHB binding site; other site 398527015705 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 398527015706 Prostaglandin dehydrogenases; Region: PGDH; cd05288 398527015707 NAD(P) binding site [chemical binding]; other site 398527015708 substrate binding site [chemical binding]; other site 398527015709 dimer interface [polypeptide binding]; other site 398527015710 hypothetical protein; Provisional; Region: PRK06194 398527015711 classical (c) SDRs; Region: SDR_c; cd05233 398527015712 NAD(P) binding site [chemical binding]; other site 398527015713 active site 398527015714 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 398527015715 NRDE protein; Region: NRDE; cl01315 398527015716 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 398527015717 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 398527015718 YceG-like family; Region: YceG; pfam02618 398527015719 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 398527015720 dimerization interface [polypeptide binding]; other site 398527015721 thymidylate kinase; Validated; Region: tmk; PRK00698 398527015722 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 398527015723 TMP-binding site; other site 398527015724 ATP-binding site [chemical binding]; other site 398527015725 DNA polymerase III subunit delta'; Validated; Region: PRK06964 398527015726 DNA polymerase III subunit delta'; Validated; Region: PRK08485 398527015727 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 398527015728 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 398527015729 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 398527015730 active site 398527015731 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 398527015732 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 398527015733 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 398527015734 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 398527015735 Mechanosensitive ion channel; Region: MS_channel; pfam00924 398527015736 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 398527015737 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 398527015738 active site 398527015739 homotetramer interface [polypeptide binding]; other site 398527015740 Predicted ATPase [General function prediction only]; Region: COG4637 398527015741 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 398527015742 Walker A/P-loop; other site 398527015743 ATP binding site [chemical binding]; other site 398527015744 Q-loop/lid; other site 398527015745 ABC transporter signature motif; other site 398527015746 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 398527015747 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 398527015748 putative ADP-binding pocket [chemical binding]; other site 398527015749 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 398527015750 Domain of unknown function DUF221; Region: DUF221; pfam02714 398527015751 hypothetical protein; Provisional; Region: PRK11505 398527015752 psiF repeat; Region: PsiF_repeat; pfam07769 398527015753 psiF repeat; Region: PsiF_repeat; pfam07769 398527015754 YciI-like protein; Reviewed; Region: PRK12866 398527015755 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 398527015756 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 398527015757 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 398527015758 Substrate binding site; other site 398527015759 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 398527015760 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 398527015761 Bacterial sugar transferase; Region: Bac_transf; pfam02397 398527015762 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 398527015763 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 398527015764 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 398527015765 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 398527015766 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 398527015767 Low molecular weight phosphatase family; Region: LMWPc; cd00115 398527015768 active site 398527015769 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 398527015770 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 398527015771 SLBB domain; Region: SLBB; pfam10531 398527015772 tyrosine kinase; Provisional; Region: PRK11519 398527015773 Chain length determinant protein; Region: Wzz; cl15801 398527015774 Chain length determinant protein; Region: Wzz; cl15801 398527015775 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 398527015776 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 398527015777 P-loop; other site 398527015778 Magnesium ion binding site [ion binding]; other site 398527015779 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 398527015780 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 398527015781 active site 398527015782 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 398527015783 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 398527015784 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 398527015785 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 398527015786 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 398527015787 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 398527015788 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 398527015789 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 398527015790 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 398527015791 NADP-binding site; other site 398527015792 homotetramer interface [polypeptide binding]; other site 398527015793 substrate binding site [chemical binding]; other site 398527015794 homodimer interface [polypeptide binding]; other site 398527015795 active site 398527015796 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 398527015797 active site 398527015798 catalytic triad [active] 398527015799 oxyanion hole [active] 398527015800 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 398527015801 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 398527015802 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 398527015803 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 398527015804 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 398527015805 putative ADP-binding pocket [chemical binding]; other site 398527015806 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 398527015807 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 398527015808 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 398527015809 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 398527015810 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 398527015811 active site 398527015812 tetramer interface; other site 398527015813 PAAR motif; Region: PAAR_motif; pfam05488 398527015814 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 398527015815 active site 398527015816 Domain of unknown function (DUF336); Region: DUF336; cl01249 398527015817 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 398527015818 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 398527015819 MOSC domain; Region: MOSC; pfam03473 398527015820 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 398527015821 active site 398527015822 dimerization interface [polypeptide binding]; other site 398527015823 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 398527015824 active site 398527015825 SAM binding site [chemical binding]; other site 398527015826 homodimer interface [polypeptide binding]; other site 398527015827 nitrite reductase subunit NirD; Provisional; Region: PRK14989 398527015828 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 398527015829 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 398527015830 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 398527015831 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 398527015832 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 398527015833 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 398527015834 [4Fe-4S] binding site [ion binding]; other site 398527015835 molybdopterin cofactor binding site; other site 398527015836 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 398527015837 molybdopterin cofactor binding site; other site 398527015838 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 398527015839 Flavodoxin; Region: Flavodoxin_1; pfam00258 398527015840 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 398527015841 FAD binding pocket [chemical binding]; other site 398527015842 FAD binding motif [chemical binding]; other site 398527015843 catalytic residues [active] 398527015844 NAD binding pocket [chemical binding]; other site 398527015845 phosphate binding motif [ion binding]; other site 398527015846 beta-alpha-beta structure motif; other site 398527015847 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 398527015848 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 398527015849 MgtC family; Region: MgtC; pfam02308 398527015850 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 398527015851 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 398527015852 trimer interface [polypeptide binding]; other site 398527015853 eyelet of channel; other site 398527015854 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 398527015855 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 398527015856 NAD binding site [chemical binding]; other site 398527015857 catalytic residues [active] 398527015858 substrate binding site [chemical binding]; other site 398527015859 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527015860 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 398527015861 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 398527015862 active site pocket [active] 398527015863 choline dehydrogenase; Validated; Region: PRK02106 398527015864 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 398527015865 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 398527015866 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527015867 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 398527015868 dimerization interface [polypeptide binding]; other site 398527015869 substrate binding pocket [chemical binding]; other site 398527015870 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 398527015871 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 398527015872 NAD(P) binding site [chemical binding]; other site 398527015873 catalytic residues [active] 398527015874 tyramine oxidase; Provisional; Region: tynA; PRK11504 398527015875 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 398527015876 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 398527015877 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 398527015878 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 398527015879 Helix-turn-helix domain; Region: HTH_18; pfam12833 398527015880 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 398527015881 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 398527015882 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 398527015883 trimer interface [polypeptide binding]; other site 398527015884 eyelet of channel; other site 398527015885 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527015886 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527015887 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 398527015888 putative dimerization interface [polypeptide binding]; other site 398527015889 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 398527015890 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 398527015891 S-adenosylmethionine binding site [chemical binding]; other site 398527015892 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 398527015893 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527015894 DNA-binding site [nucleotide binding]; DNA binding site 398527015895 FCD domain; Region: FCD; pfam07729 398527015896 aminotransferase; Validated; Region: PRK07046 398527015897 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 398527015898 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 398527015899 catalytic residue [active] 398527015900 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 398527015901 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 398527015902 short chain dehydrogenase; Provisional; Region: PRK06180 398527015903 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 398527015904 NADP binding site [chemical binding]; other site 398527015905 active site 398527015906 steroid binding site; other site 398527015907 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 398527015908 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 398527015909 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527015910 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 398527015911 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 398527015912 putative C-terminal domain interface [polypeptide binding]; other site 398527015913 putative GSH binding site (G-site) [chemical binding]; other site 398527015914 putative dimer interface [polypeptide binding]; other site 398527015915 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 398527015916 putative N-terminal domain interface [polypeptide binding]; other site 398527015917 putative dimer interface [polypeptide binding]; other site 398527015918 putative substrate binding pocket (H-site) [chemical binding]; other site 398527015919 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 398527015920 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 398527015921 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 398527015922 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 398527015923 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 398527015924 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 398527015925 Transglycosylase; Region: Transgly; pfam00912 398527015926 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 398527015927 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527015928 D-galactonate transporter; Region: 2A0114; TIGR00893 398527015929 putative substrate translocation pore; other site 398527015930 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527015931 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 398527015932 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 398527015933 Cupin domain; Region: Cupin_2; pfam07883 398527015934 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 398527015935 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 398527015936 MarR family; Region: MarR_2; cl17246 398527015937 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 398527015938 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 398527015939 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 398527015940 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 398527015941 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 398527015942 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 398527015943 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527015944 putative substrate translocation pore; other site 398527015945 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527015946 Protein of unknown function (DUF2964); Region: DUF2964; pfam11177 398527015947 HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401 398527015948 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 398527015949 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 398527015950 NAD binding site [chemical binding]; other site 398527015951 metal binding site [ion binding]; metal-binding site 398527015952 active site 398527015953 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 398527015954 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 398527015955 Cytochrome c; Region: Cytochrom_C; pfam00034 398527015956 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 398527015957 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 398527015958 D-pathway; other site 398527015959 Putative ubiquinol binding site [chemical binding]; other site 398527015960 Low-spin heme (heme b) binding site [chemical binding]; other site 398527015961 Putative water exit pathway; other site 398527015962 Binuclear center (heme o3/CuB) [ion binding]; other site 398527015963 K-pathway; other site 398527015964 Putative proton exit pathway; other site 398527015965 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 398527015966 Subunit I/III interface [polypeptide binding]; other site 398527015967 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 398527015968 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 398527015969 Cytochrome c; Region: Cytochrom_C; pfam00034 398527015970 thiamine pyrophosphate protein; Provisional; Region: PRK08273 398527015971 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 398527015972 PYR/PP interface [polypeptide binding]; other site 398527015973 dimer interface [polypeptide binding]; other site 398527015974 tetramer interface [polypeptide binding]; other site 398527015975 TPP binding site [chemical binding]; other site 398527015976 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 398527015977 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 398527015978 TPP-binding site [chemical binding]; other site 398527015979 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 398527015980 INT_SG1, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 1, C-terminal catalytic domain. The CD contains mainly predicted integrase/recombinase and site-specific XerD recombinases. The members of this CD are found predominantly in...; Region: INT_SG1_C; cd01183 398527015981 Int/Topo IB signature motif; other site 398527015982 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 398527015983 Protein of unknown function (DUF1571); Region: DUF1571; pfam07608 398527015984 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 398527015985 Predicted membrane protein [Function unknown]; Region: COG2119 398527015986 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 398527015987 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 398527015988 Low affinity iron permease; Region: Iron_permease; pfam04120 398527015989 Uncharacterized conserved protein [Function unknown]; Region: COG3791 398527015990 Protein of unknown function (DUF1810); Region: DUF1810; pfam08837 398527015991 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 398527015992 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 398527015993 substrate binding pocket [chemical binding]; other site 398527015994 membrane-bound complex binding site; other site 398527015995 hinge residues; other site 398527015996 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 398527015997 dimanganese center [ion binding]; other site 398527015998 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527015999 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527016000 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 398527016001 putative dimerization interface [polypeptide binding]; other site 398527016002 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 398527016003 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 398527016004 inhibitor-cofactor binding pocket; inhibition site 398527016005 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527016006 catalytic residue [active] 398527016007 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 398527016008 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 398527016009 substrate binding site [chemical binding]; other site 398527016010 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 398527016011 substrate binding site [chemical binding]; other site 398527016012 ligand binding site [chemical binding]; other site 398527016013 Predicted transcriptional regulators [Transcription]; Region: COG1733 398527016014 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 398527016015 short chain dehydrogenase; Provisional; Region: PRK06179 398527016016 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 398527016017 NADP binding site [chemical binding]; other site 398527016018 active site 398527016019 steroid binding site; other site 398527016020 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 398527016021 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 398527016022 putative NAD(P) binding site [chemical binding]; other site 398527016023 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 398527016024 MarR family; Region: MarR_2; pfam12802 398527016025 Sulfatase; Region: Sulfatase; cl17466 398527016026 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 398527016027 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 398527016028 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527016029 putative substrate translocation pore; other site 398527016030 D-lactate dehydrogenase; Provisional; Region: PRK11183 398527016031 FAD binding domain; Region: FAD_binding_4; pfam01565 398527016032 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 398527016033 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527016034 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 398527016035 putative dimerization interface [polypeptide binding]; other site 398527016036 putative substrate binding pocket [chemical binding]; other site 398527016037 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 398527016038 Ligand Binding Site [chemical binding]; other site 398527016039 GYD domain; Region: GYD; pfam08734 398527016040 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 398527016041 Tim44-like domain; Region: Tim44; pfam04280 398527016042 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 398527016043 FOG: CBS domain [General function prediction only]; Region: COG0517 398527016044 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 398527016045 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527016046 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 398527016047 dimerization interface [polypeptide binding]; other site 398527016048 transaminase; Validated; Region: PRK07324 398527016049 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 398527016050 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527016051 homodimer interface [polypeptide binding]; other site 398527016052 catalytic residue [active] 398527016053 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 398527016054 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 398527016055 hydroxyglutarate oxidase; Provisional; Region: PRK11728 398527016056 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 398527016057 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 398527016058 substrate binding pocket [chemical binding]; other site 398527016059 membrane-bound complex binding site; other site 398527016060 hinge residues; other site 398527016061 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 398527016062 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 398527016063 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 398527016064 YheO-like PAS domain; Region: PAS_6; pfam08348 398527016065 HTH domain; Region: HTH_22; pfam13309 398527016066 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 398527016067 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527016068 Walker A motif; other site 398527016069 ATP binding site [chemical binding]; other site 398527016070 Walker B motif; other site 398527016071 arginine finger; other site 398527016072 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 398527016073 Protein of unknown function (DUF917); Region: DUF917; pfam06032 398527016074 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 398527016075 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 398527016076 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 398527016077 dimer interface [polypeptide binding]; other site 398527016078 active site 398527016079 heme binding site [chemical binding]; other site 398527016080 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 398527016081 NnrU protein; Region: NnrU; pfam07298 398527016082 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_10; cd04667 398527016083 nudix motif; other site 398527016084 CHASE2 domain; Region: CHASE2; pfam05226 398527016085 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 398527016086 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 398527016087 ligand binding site [chemical binding]; other site 398527016088 FecR protein; Region: FecR; pfam04773 398527016089 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 398527016090 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 398527016091 Na binding site [ion binding]; other site 398527016092 benzoate transport; Region: 2A0115; TIGR00895 398527016093 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527016094 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527016095 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 398527016096 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 398527016097 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 398527016098 active site 398527016099 Protein of unknown function (DUF3455); Region: DUF3455; pfam11937 398527016100 56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694 398527016101 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 398527016102 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 398527016103 substrate binding pocket [chemical binding]; other site 398527016104 membrane-bound complex binding site; other site 398527016105 hinge residues; other site 398527016106 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 398527016107 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527016108 ABC-ATPase subunit interface; other site 398527016109 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 398527016110 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527016111 dimer interface [polypeptide binding]; other site 398527016112 putative PBP binding loops; other site 398527016113 ABC-ATPase subunit interface; other site 398527016114 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 398527016115 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 398527016116 Walker A/P-loop; other site 398527016117 ATP binding site [chemical binding]; other site 398527016118 Q-loop/lid; other site 398527016119 ABC transporter signature motif; other site 398527016120 Walker B; other site 398527016121 D-loop; other site 398527016122 H-loop/switch region; other site 398527016123 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 398527016124 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 398527016125 active site 398527016126 non-prolyl cis peptide bond; other site 398527016127 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 398527016128 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 398527016129 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 398527016130 PLD-like domain; Region: PLDc_2; pfam13091 398527016131 putative active site [active] 398527016132 catalytic site [active] 398527016133 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 398527016134 PLD-like domain; Region: PLDc_2; pfam13091 398527016135 putative active site [active] 398527016136 catalytic site [active] 398527016137 Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969 398527016138 putative active site [active] 398527016139 putative metal binding site [ion binding]; other site 398527016140 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 398527016141 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 398527016142 putative ADP-binding pocket [chemical binding]; other site 398527016143 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 398527016144 Putative amidotransferase; Region: DUF4066; pfam13278 398527016145 conserved cys residue [active] 398527016146 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 398527016147 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527016148 DNA-binding site [nucleotide binding]; DNA binding site 398527016149 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 398527016150 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527016151 homodimer interface [polypeptide binding]; other site 398527016152 catalytic residue [active] 398527016153 hypothetical protein; Provisional; Region: PRK06486 398527016154 intersubunit interface [polypeptide binding]; other site 398527016155 active site 398527016156 Zn2+ binding site [ion binding]; other site 398527016157 prolyl-tRNA synthetase; Provisional; Region: PRK12325 398527016158 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 398527016159 motif 1; other site 398527016160 dimer interface [polypeptide binding]; other site 398527016161 active site 398527016162 motif 2; other site 398527016163 motif 3; other site 398527016164 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 398527016165 anticodon binding site; other site 398527016166 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 398527016167 homotrimer interaction site [polypeptide binding]; other site 398527016168 putative active site [active] 398527016169 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 398527016170 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 398527016171 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 398527016172 mce related protein; Region: MCE; pfam02470 398527016173 mce related protein; Region: MCE; pfam02470 398527016174 mce related protein; Region: MCE; pfam02470 398527016175 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 398527016176 Organic solvent tolerance protein; Region: OstA_C; pfam04453 398527016177 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 398527016178 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 398527016179 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 398527016180 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 398527016181 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 398527016182 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 398527016183 Surface antigen; Region: Bac_surface_Ag; pfam01103 398527016184 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 398527016185 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 398527016186 PYR/PP interface [polypeptide binding]; other site 398527016187 dimer interface [polypeptide binding]; other site 398527016188 TPP binding site [chemical binding]; other site 398527016189 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 398527016190 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 398527016191 TPP-binding site [chemical binding]; other site 398527016192 dimer interface [polypeptide binding]; other site 398527016193 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 398527016194 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 398527016195 TPP-binding site [chemical binding]; other site 398527016196 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 398527016197 dimer interface [polypeptide binding]; other site 398527016198 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 398527016199 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 398527016200 conserved cys residue [active] 398527016201 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527016202 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527016203 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 398527016204 active site 398527016205 SUMO-1 interface [polypeptide binding]; other site 398527016206 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527016207 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527016208 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 398527016209 putative effector binding pocket; other site 398527016210 putative dimerization interface [polypeptide binding]; other site 398527016211 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 398527016212 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 398527016213 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527016214 putative substrate translocation pore; other site 398527016215 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 398527016216 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 398527016217 HlyD family secretion protein; Region: HlyD_3; pfam13437 398527016218 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 398527016219 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 398527016220 catalytic residue [active] 398527016221 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 398527016222 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 398527016223 dimer interface [polypeptide binding]; other site 398527016224 phosphorylation site [posttranslational modification] 398527016225 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527016226 ATP binding site [chemical binding]; other site 398527016227 Mg2+ binding site [ion binding]; other site 398527016228 G-X-G motif; other site 398527016229 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 398527016230 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527016231 active site 398527016232 phosphorylation site [posttranslational modification] 398527016233 intermolecular recognition site; other site 398527016234 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 398527016235 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527016236 active site 398527016237 phosphorylation site [posttranslational modification] 398527016238 intermolecular recognition site; other site 398527016239 dimerization interface [polypeptide binding]; other site 398527016240 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 398527016241 DNA binding residues [nucleotide binding] 398527016242 dimerization interface [polypeptide binding]; other site 398527016243 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 398527016244 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 398527016245 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527016246 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 398527016247 putative effector binding pocket; other site 398527016248 putative dimerization interface [polypeptide binding]; other site 398527016249 Domain of unknown function (DUF2760); Region: DUF2760; pfam10816 398527016250 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 398527016251 nucleotide binding site [chemical binding]; other site 398527016252 putative NEF/HSP70 interaction site [polypeptide binding]; other site 398527016253 SBD interface [polypeptide binding]; other site 398527016254 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 398527016255 nucleotide binding site [chemical binding]; other site 398527016256 putative NEF/HSP70 interaction site [polypeptide binding]; other site 398527016257 SBD interface [polypeptide binding]; other site 398527016258 DNA-K related protein; Region: DUF3731; pfam12531 398527016259 short chain dehydrogenase; Provisional; Region: PRK06500 398527016260 classical (c) SDRs; Region: SDR_c; cd05233 398527016261 NAD(P) binding site [chemical binding]; other site 398527016262 active site 398527016263 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527016264 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527016265 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 398527016266 putative effector binding pocket; other site 398527016267 putative dimerization interface [polypeptide binding]; other site 398527016268 GAF domain; Region: GAF; pfam01590 398527016269 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 398527016270 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 398527016271 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 398527016272 metal binding site [ion binding]; metal-binding site 398527016273 active site 398527016274 I-site; other site 398527016275 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527016276 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527016277 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 398527016278 putative effector binding pocket; other site 398527016279 dimerization interface [polypeptide binding]; other site 398527016280 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 398527016281 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 398527016282 active site 398527016283 motif I; other site 398527016284 motif II; other site 398527016285 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 398527016286 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 398527016287 catalytic residue [active] 398527016288 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 398527016289 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527016290 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 398527016291 dimerization interface [polypeptide binding]; other site 398527016292 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 398527016293 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 398527016294 NAD(P) binding site [chemical binding]; other site 398527016295 active site 398527016296 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 398527016297 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527016298 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425 398527016299 dimerization interface [polypeptide binding]; other site 398527016300 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 398527016301 active site clefts [active] 398527016302 zinc binding site [ion binding]; other site 398527016303 dimer interface [polypeptide binding]; other site 398527016304 cyanate hydratase; Validated; Region: PRK02866 398527016305 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 398527016306 oligomer interface [polypeptide binding]; other site 398527016307 active site 398527016308 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527016309 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527016310 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 398527016311 putative dimerization interface [polypeptide binding]; other site 398527016312 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 398527016313 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 398527016314 FMN-binding pocket [chemical binding]; other site 398527016315 flavin binding motif; other site 398527016316 phosphate binding motif [ion binding]; other site 398527016317 beta-alpha-beta structure motif; other site 398527016318 NAD binding pocket [chemical binding]; other site 398527016319 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 398527016320 catalytic loop [active] 398527016321 iron binding site [ion binding]; other site 398527016322 Muconolactone delta-isomerase; Region: MIase; pfam02426 398527016323 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 398527016324 Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460 398527016325 dimer interface [polypeptide binding]; other site 398527016326 active site 398527016327 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 398527016328 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 398527016329 octamer interface [polypeptide binding]; other site 398527016330 active site 398527016331 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 398527016332 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527016333 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in benzoate catabolism; contains the type 2 periplasmic binding fold; Region: PBP2_BenM_CatM_CatR; cd08445 398527016334 dimerizarion interface [polypeptide binding]; other site 398527016335 CrgA pocket; other site 398527016336 substrate binding pocket [chemical binding]; other site 398527016337 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527016338 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527016339 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 398527016340 substrate binding pocket [chemical binding]; other site 398527016341 dimerization interface [polypeptide binding]; other site 398527016342 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 398527016343 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 398527016344 [2Fe-2S] cluster binding site [ion binding]; other site 398527016345 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 398527016346 putative alpha subunit interface [polypeptide binding]; other site 398527016347 putative active site [active] 398527016348 putative substrate binding site [chemical binding]; other site 398527016349 Fe binding site [ion binding]; other site 398527016350 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 398527016351 inter-subunit interface; other site 398527016352 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 398527016353 active site 1 [active] 398527016354 dimer interface [polypeptide binding]; other site 398527016355 hexamer interface [polypeptide binding]; other site 398527016356 active site 2 [active] 398527016357 active site 1 [active] 398527016358 dimer interface [polypeptide binding]; other site 398527016359 hexamer interface [polypeptide binding]; other site 398527016360 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 398527016361 active site 2 [active] 398527016362 metabolite-proton symporter; Region: 2A0106; TIGR00883 398527016363 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527016364 putative substrate translocation pore; other site 398527016365 PAS domain; Region: PAS_9; pfam13426 398527016366 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 398527016367 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 398527016368 putative active site [active] 398527016369 heme pocket [chemical binding]; other site 398527016370 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 398527016371 dimer interface [polypeptide binding]; other site 398527016372 phosphorylation site [posttranslational modification] 398527016373 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527016374 ATP binding site [chemical binding]; other site 398527016375 Mg2+ binding site [ion binding]; other site 398527016376 G-X-G motif; other site 398527016377 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 398527016378 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 398527016379 active site 398527016380 SnoaL-like domain; Region: SnoaL_4; pfam13577 398527016381 Amidase; Region: Amidase; cl11426 398527016382 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 398527016383 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 398527016384 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 398527016385 NAD(P) binding site [chemical binding]; other site 398527016386 active site 398527016387 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 398527016388 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527016389 active site 398527016390 phosphorylation site [posttranslational modification] 398527016391 intermolecular recognition site; other site 398527016392 dimerization interface [polypeptide binding]; other site 398527016393 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 398527016394 DNA binding residues [nucleotide binding] 398527016395 dimerization interface [polypeptide binding]; other site 398527016396 Flavin Reductases; Region: FlaRed; cl00801 398527016397 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 398527016398 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527016399 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 398527016400 dimerization interface [polypeptide binding]; other site 398527016401 metabolite-proton symporter; Region: 2A0106; TIGR00883 398527016402 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527016403 putative substrate translocation pore; other site 398527016404 amidase; Provisional; Region: PRK07486 398527016405 Amidase; Region: Amidase; pfam01425 398527016406 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 398527016407 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 398527016408 trimer interface [polypeptide binding]; other site 398527016409 eyelet of channel; other site 398527016410 CopC domain; Region: CopC; pfam04234 398527016411 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 398527016412 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 398527016413 ProQ/FINO family; Region: ProQ; pfam04352 398527016414 Activator of osmoprotectant transporter ProP [Signal transduction mechanisms]; Region: ProQ; COG3109 398527016415 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527016416 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527016417 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 398527016418 dimerization interface [polypeptide binding]; other site 398527016419 metabolite-proton symporter; Region: 2A0106; TIGR00883 398527016420 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 398527016421 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 398527016422 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 398527016423 enoyl-CoA hydratase; Provisional; Region: PRK06688 398527016424 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 398527016425 substrate binding site [chemical binding]; other site 398527016426 oxyanion hole (OAH) forming residues; other site 398527016427 trimer interface [polypeptide binding]; other site 398527016428 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 398527016429 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 398527016430 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 398527016431 acyl-activating enzyme (AAE) consensus motif; other site 398527016432 acyl-activating enzyme (AAE) consensus motif; other site 398527016433 putative AMP binding site [chemical binding]; other site 398527016434 putative active site [active] 398527016435 putative CoA binding site [chemical binding]; other site 398527016436 4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193 398527016437 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 398527016438 catalytic loop [active] 398527016439 iron binding site [ion binding]; other site 398527016440 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 398527016441 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 398527016442 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 398527016443 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 398527016444 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 398527016445 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 398527016446 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 398527016447 putative hydrophobic ligand binding site [chemical binding]; other site 398527016448 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 398527016449 Flavoprotein; Region: Flavoprotein; pfam02441 398527016450 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 398527016451 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527016452 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527016453 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 398527016454 dimerization interface [polypeptide binding]; other site 398527016455 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 398527016456 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 398527016457 dimer interface [polypeptide binding]; other site 398527016458 phosphorylation site [posttranslational modification] 398527016459 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527016460 ATP binding site [chemical binding]; other site 398527016461 Mg2+ binding site [ion binding]; other site 398527016462 G-X-G motif; other site 398527016463 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 398527016464 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527016465 active site 398527016466 phosphorylation site [posttranslational modification] 398527016467 intermolecular recognition site; other site 398527016468 dimerization interface [polypeptide binding]; other site 398527016469 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 398527016470 DNA binding site [nucleotide binding] 398527016471 Outer membrane efflux protein; Region: OEP; pfam02321 398527016472 Outer membrane efflux protein; Region: OEP; pfam02321 398527016473 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 398527016474 HlyD family secretion protein; Region: HlyD_3; pfam13437 398527016475 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 398527016476 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 398527016477 hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472 398527016478 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 398527016479 ligand binding site; other site 398527016480 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 398527016481 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527016482 active site 398527016483 phosphorylation site [posttranslational modification] 398527016484 intermolecular recognition site; other site 398527016485 dimerization interface [polypeptide binding]; other site 398527016486 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 398527016487 DNA binding site [nucleotide binding] 398527016488 sensor protein QseC; Provisional; Region: PRK10337 398527016489 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 398527016490 dimer interface [polypeptide binding]; other site 398527016491 phosphorylation site [posttranslational modification] 398527016492 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527016493 ATP binding site [chemical binding]; other site 398527016494 G-X-G motif; other site 398527016495 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 398527016496 hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472 398527016497 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 398527016498 ligand binding site; other site 398527016499 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 398527016500 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 398527016501 B12 binding site [chemical binding]; other site 398527016502 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 398527016503 FeS/SAM binding site; other site 398527016504 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 398527016505 DNA-binding site [nucleotide binding]; DNA binding site 398527016506 RNA-binding motif; other site 398527016507 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 398527016508 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 398527016509 tetramerization interface [polypeptide binding]; other site 398527016510 NAD(P) binding site [chemical binding]; other site 398527016511 catalytic residues [active] 398527016512 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 398527016513 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 398527016514 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274 398527016515 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 398527016516 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 398527016517 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 398527016518 NADP binding site [chemical binding]; other site 398527016519 homodimer interface [polypeptide binding]; other site 398527016520 active site 398527016521 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 398527016522 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 398527016523 dimerization interface [polypeptide binding]; other site 398527016524 putative Zn2+ binding site [ion binding]; other site 398527016525 putative DNA binding site [nucleotide binding]; other site 398527016526 Bacterial transcriptional regulator; Region: IclR; pfam01614 398527016527 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 398527016528 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 398527016529 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 398527016530 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 398527016531 metal binding site [ion binding]; metal-binding site 398527016532 substrate binding pocket [chemical binding]; other site 398527016533 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527016534 D-galactonate transporter; Region: 2A0114; TIGR00893 398527016535 putative substrate translocation pore; other site 398527016536 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 398527016537 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 398527016538 NAD(P) binding site [chemical binding]; other site 398527016539 active site 398527016540 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527016541 DNA-binding site [nucleotide binding]; DNA binding site 398527016542 Transcriptional regulators [Transcription]; Region: FadR; COG2186 398527016543 FCD domain; Region: FCD; pfam07729 398527016544 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 398527016545 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 398527016546 putative C-terminal domain interface [polypeptide binding]; other site 398527016547 putative GSH binding site (G-site) [chemical binding]; other site 398527016548 putative dimer interface [polypeptide binding]; other site 398527016549 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 398527016550 N-terminal domain interface [polypeptide binding]; other site 398527016551 dimer interface [polypeptide binding]; other site 398527016552 substrate binding pocket (H-site) [chemical binding]; other site 398527016553 Chromate transporter; Region: Chromate_transp; pfam02417 398527016554 Chromate transporter; Region: Chromate_transp; pfam02417 398527016555 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 398527016556 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 398527016557 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 398527016558 active site 398527016559 metal binding site [ion binding]; metal-binding site 398527016560 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 398527016561 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 398527016562 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 398527016563 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527016564 DNA-binding site [nucleotide binding]; DNA binding site 398527016565 FCD domain; Region: FCD; pfam07729 398527016566 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 398527016567 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 398527016568 trimer interface [polypeptide binding]; other site 398527016569 eyelet of channel; other site 398527016570 putative chaperone; Provisional; Region: PRK11678 398527016571 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 398527016572 nucleotide binding site [chemical binding]; other site 398527016573 putative NEF/HSP70 interaction site [polypeptide binding]; other site 398527016574 SBD interface [polypeptide binding]; other site 398527016575 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 398527016576 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 398527016577 P-loop; other site 398527016578 Magnesium ion binding site [ion binding]; other site 398527016579 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 398527016580 Magnesium ion binding site [ion binding]; other site 398527016581 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 398527016582 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 398527016583 threonine dehydratase; Reviewed; Region: PRK09224 398527016584 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 398527016585 tetramer interface [polypeptide binding]; other site 398527016586 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527016587 catalytic residue [active] 398527016588 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 398527016589 putative Ile/Val binding site [chemical binding]; other site 398527016590 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 398527016591 putative Ile/Val binding site [chemical binding]; other site 398527016592 Type IV secretory pathway, VirJ component [Intracellular trafficking and secretion]; Region: VirJ; COG3946 398527016593 Bacterial virulence protein (VirJ); Region: VirJ; pfam06057 398527016594 Predicted integral membrane protein [Function unknown]; Region: COG0392 398527016595 Uncharacterized conserved protein [Function unknown]; Region: COG2898 398527016596 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 398527016597 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527016598 putative transporter; Provisional; Region: PRK10504 398527016599 putative substrate translocation pore; other site 398527016600 Predicted membrane protein [Function unknown]; Region: COG2323 398527016601 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 398527016602 active site 398527016603 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 398527016604 S-adenosylmethionine binding site [chemical binding]; other site 398527016605 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 398527016606 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 398527016607 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 398527016608 putative active site [active] 398527016609 heme pocket [chemical binding]; other site 398527016610 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 398527016611 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 398527016612 putative active site [active] 398527016613 heme pocket [chemical binding]; other site 398527016614 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 398527016615 dimer interface [polypeptide binding]; other site 398527016616 phosphorylation site [posttranslational modification] 398527016617 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527016618 ATP binding site [chemical binding]; other site 398527016619 Mg2+ binding site [ion binding]; other site 398527016620 G-X-G motif; other site 398527016621 Response regulator receiver domain; Region: Response_reg; pfam00072 398527016622 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527016623 active site 398527016624 phosphorylation site [posttranslational modification] 398527016625 intermolecular recognition site; other site 398527016626 dimerization interface [polypeptide binding]; other site 398527016627 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 398527016628 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 398527016629 Uncharacterized conserved protein [Function unknown]; Region: COG2128 398527016630 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 398527016631 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 398527016632 Tar ligand binding domain homologue; Region: TarH; pfam02203 398527016633 dimer interface [polypeptide binding]; other site 398527016634 ligand binding site [chemical binding]; other site 398527016635 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 398527016636 dimerization interface [polypeptide binding]; other site 398527016637 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 398527016638 dimer interface [polypeptide binding]; other site 398527016639 putative CheW interface [polypeptide binding]; other site 398527016640 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527016641 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527016642 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 398527016643 dimerization interface [polypeptide binding]; other site 398527016644 putative transporter; Provisional; Region: PRK10504 398527016645 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527016646 putative substrate translocation pore; other site 398527016647 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 398527016648 short chain dehydrogenase; Provisional; Region: PRK06197 398527016649 NAD(P) binding site [chemical binding]; other site 398527016650 active site 398527016651 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527016652 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527016653 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 398527016654 putative effector binding pocket; other site 398527016655 dimerization interface [polypeptide binding]; other site 398527016656 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 398527016657 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 398527016658 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 398527016659 active site 398527016660 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 398527016661 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527016662 putative substrate translocation pore; other site 398527016663 SpoVR family protein; Provisional; Region: PRK11767 398527016664 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 398527016665 hypothetical protein; Provisional; Region: PRK05325 398527016666 PrkA family serine protein kinase; Provisional; Region: PRK15455 398527016667 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 398527016668 Walker A motif; other site 398527016669 ATP binding site [chemical binding]; other site 398527016670 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 398527016671 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 398527016672 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 398527016673 Tar ligand binding domain homologue; Region: TarH; pfam02203 398527016674 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 398527016675 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 398527016676 dimerization interface [polypeptide binding]; other site 398527016677 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 398527016678 dimer interface [polypeptide binding]; other site 398527016679 putative CheW interface [polypeptide binding]; other site 398527016680 Transcriptional regulators [Transcription]; Region: PurR; COG1609 398527016681 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 398527016682 DNA binding site [nucleotide binding] 398527016683 domain linker motif; other site 398527016684 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 398527016685 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 398527016686 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 398527016687 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 398527016688 TM-ABC transporter signature motif; other site 398527016689 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 398527016690 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 398527016691 Walker A/P-loop; other site 398527016692 ATP binding site [chemical binding]; other site 398527016693 Q-loop/lid; other site 398527016694 ABC transporter signature motif; other site 398527016695 Walker B; other site 398527016696 D-loop; other site 398527016697 H-loop/switch region; other site 398527016698 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 398527016699 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 398527016700 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 398527016701 ligand binding site [chemical binding]; other site 398527016702 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 398527016703 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 398527016704 oligomer interface [polypeptide binding]; other site 398527016705 metal binding site [ion binding]; metal-binding site 398527016706 metal binding site [ion binding]; metal-binding site 398527016707 putative Cl binding site [ion binding]; other site 398527016708 basic sphincter; other site 398527016709 hydrophobic gate; other site 398527016710 periplasmic entrance; other site 398527016711 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 398527016712 Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173 398527016713 AAA domain; Region: AAA_33; pfam13671 398527016714 AAA domain; Region: AAA_17; pfam13207 398527016715 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 398527016716 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 398527016717 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 398527016718 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 398527016719 AsnC family; Region: AsnC_trans_reg; pfam01037 398527016720 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527016721 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527016722 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 398527016723 putative effector binding pocket; other site 398527016724 putative dimerization interface [polypeptide binding]; other site 398527016725 LTXXQ motif family protein; Region: LTXXQ; pfam07813 398527016726 PGDYG protein; Region: PGDYG; pfam14083 398527016727 Protein of unknown function (DUF3022); Region: DUF3022; pfam11226 398527016728 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 398527016729 Transcriptional regulators [Transcription]; Region: PurR; COG1609 398527016730 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 398527016731 DNA binding site [nucleotide binding] 398527016732 domain linker motif; other site 398527016733 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 398527016734 putative dimerization interface [polypeptide binding]; other site 398527016735 putative ligand binding site [chemical binding]; other site 398527016736 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 398527016737 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 398527016738 dimerization interface [polypeptide binding]; other site 398527016739 ligand binding site [chemical binding]; other site 398527016740 NADP binding site [chemical binding]; other site 398527016741 catalytic site [active] 398527016742 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527016743 D-galactonate transporter; Region: 2A0114; TIGR00893 398527016744 putative substrate translocation pore; other site 398527016745 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 398527016746 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 398527016747 substrate binding site [chemical binding]; other site 398527016748 ATP binding site [chemical binding]; other site 398527016749 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 398527016750 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527016751 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 398527016752 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 398527016753 putative dimerization interface [polypeptide binding]; other site 398527016754 Predicted membrane protein [Function unknown]; Region: COG2855 398527016755 glutathione s-transferase; Provisional; Region: PTZ00057 398527016756 GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039 398527016757 GSH binding site (G-site) [chemical binding]; other site 398527016758 C-terminal domain interface [polypeptide binding]; other site 398527016759 dimer interface [polypeptide binding]; other site 398527016760 C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases; Region: GST_C_Sigma_like; cd03192 398527016761 dimer interface [polypeptide binding]; other site 398527016762 N-terminal domain interface [polypeptide binding]; other site 398527016763 substrate binding pocket (H-site) [chemical binding]; other site 398527016764 putative voltage-gated ClC-type chloride channel ClcB; Provisional; Region: PRK01862 398527016765 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 398527016766 Cl- selectivity filter; other site 398527016767 Cl- binding residues [ion binding]; other site 398527016768 pore gating glutamate residue; other site 398527016769 dimer interface [polypeptide binding]; other site 398527016770 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 398527016771 Phospholipase B; Region: Phospholip_B; pfam04916 398527016772 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 398527016773 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 398527016774 Helix-turn-helix domain; Region: HTH_18; pfam12833 398527016775 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527016776 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 398527016777 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527016778 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527016779 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 398527016780 putative effector binding pocket; other site 398527016781 dimerization interface [polypeptide binding]; other site 398527016782 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 398527016783 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 398527016784 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 398527016785 HlyD family secretion protein; Region: HlyD_3; pfam13437 398527016786 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 398527016787 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 398527016788 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 398527016789 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 398527016790 putative acyl-acceptor binding pocket; other site 398527016791 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 398527016792 Transglycosylase; Region: Transgly; pfam00912 398527016793 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 398527016794 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 398527016795 Tetratricopeptide repeat; Region: TPR_16; pfam13432 398527016796 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 398527016797 binding surface 398527016798 TPR motif; other site 398527016799 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 398527016800 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 398527016801 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 398527016802 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 398527016803 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 398527016804 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 398527016805 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 398527016806 dimer interface [polypeptide binding]; other site 398527016807 putative CheW interface [polypeptide binding]; other site 398527016808 Transposase, Mutator family; Region: Transposase_mut; pfam00872 398527016809 MULE transposase domain; Region: MULE; pfam10551 398527016810 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 398527016811 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527016812 dimer interface [polypeptide binding]; other site 398527016813 conserved gate region; other site 398527016814 putative PBP binding loops; other site 398527016815 ABC-ATPase subunit interface; other site 398527016816 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527016817 dimer interface [polypeptide binding]; other site 398527016818 conserved gate region; other site 398527016819 putative PBP binding loops; other site 398527016820 ABC-ATPase subunit interface; other site 398527016821 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 398527016822 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 398527016823 Walker A/P-loop; other site 398527016824 ATP binding site [chemical binding]; other site 398527016825 Q-loop/lid; other site 398527016826 ABC transporter signature motif; other site 398527016827 Walker B; other site 398527016828 D-loop; other site 398527016829 H-loop/switch region; other site 398527016830 TOBE domain; Region: TOBE_2; pfam08402 398527016831 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 398527016832 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 398527016833 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 398527016834 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 398527016835 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 398527016836 dimerization interface [polypeptide binding]; other site 398527016837 substrate binding site [chemical binding]; other site 398527016838 active site 398527016839 calcium binding site [ion binding]; other site 398527016840 Predicted Fe-S protein [General function prediction only]; Region: COG3313 398527016841 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 398527016842 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 398527016843 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 398527016844 FMN binding site [chemical binding]; other site 398527016845 substrate binding site [chemical binding]; other site 398527016846 putative catalytic residue [active] 398527016847 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 398527016848 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 398527016849 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 398527016850 ABC transporter; Region: ABC_tran_2; pfam12848 398527016851 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 398527016852 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 398527016853 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 398527016854 Dodecin; Region: Dodecin; pfam07311 398527016855 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 398527016856 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 398527016857 putative ligand binding site [chemical binding]; other site 398527016858 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 398527016859 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 398527016860 TM-ABC transporter signature motif; other site 398527016861 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 398527016862 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 398527016863 TM-ABC transporter signature motif; other site 398527016864 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 398527016865 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 398527016866 Walker A/P-loop; other site 398527016867 ATP binding site [chemical binding]; other site 398527016868 Q-loop/lid; other site 398527016869 ABC transporter signature motif; other site 398527016870 Walker B; other site 398527016871 D-loop; other site 398527016872 H-loop/switch region; other site 398527016873 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 398527016874 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527016875 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527016876 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_4; cd08463 398527016877 putative substrate binding pocket [chemical binding]; other site 398527016878 putative dimerization interface [polypeptide binding]; other site 398527016879 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 398527016880 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 398527016881 active site 398527016882 putative substrate binding pocket [chemical binding]; other site 398527016883 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 398527016884 active site 398527016885 homotetramer interface [polypeptide binding]; other site 398527016886 Predicted membrane protein [Function unknown]; Region: COG3748 398527016887 Protein of unknown function (DUF989); Region: DUF989; pfam06181 398527016888 Cytochrome c; Region: Cytochrom_C; pfam00034 398527016889 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 398527016890 ureidoglycolate hydrolase; Provisional; Region: PRK03606 398527016891 allantoicase; Provisional; Region: PRK13257 398527016892 Allantoicase repeat; Region: Allantoicase; pfam03561 398527016893 Allantoicase repeat; Region: Allantoicase; pfam03561 398527016894 OHCU decarboxylase; Region: UHCUDC; TIGR03164 398527016895 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 398527016896 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 398527016897 active site 398527016898 catalytic site [active] 398527016899 tetramer interface [polypeptide binding]; other site 398527016900 Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126 398527016901 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 398527016902 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 398527016903 Na binding site [ion binding]; other site 398527016904 putative substrate binding site [chemical binding]; other site 398527016905 Transcriptional regulators [Transcription]; Region: GntR; COG1802 398527016906 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527016907 DNA-binding site [nucleotide binding]; DNA binding site 398527016908 FCD domain; Region: FCD; pfam07729 398527016909 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 398527016910 dimer interface [polypeptide binding]; other site 398527016911 catalytic triad [active] 398527016912 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 398527016913 nucleoside/Zn binding site; other site 398527016914 dimer interface [polypeptide binding]; other site 398527016915 catalytic motif [active] 398527016916 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 398527016917 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 398527016918 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 398527016919 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 398527016920 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 398527016921 FeS/SAM binding site; other site 398527016922 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 398527016923 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 398527016924 Fe-S cluster binding site [ion binding]; other site 398527016925 active site 398527016926 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 398527016927 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 398527016928 NADH(P)-binding; Region: NAD_binding_10; pfam13460 398527016929 NAD(P) binding site [chemical binding]; other site 398527016930 active site 398527016931 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527016932 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527016933 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 398527016934 putative effector binding pocket; other site 398527016935 dimerization interface [polypeptide binding]; other site 398527016936 Cupin domain; Region: Cupin_2; pfam07883 398527016937 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 398527016938 Uncharacterized conserved protein [Function unknown]; Region: COG2128 398527016939 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 398527016940 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 398527016941 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 398527016942 DNA binding residues [nucleotide binding] 398527016943 Protein of unknown function DUF72; Region: DUF72; pfam01904 398527016944 Putative ParB-like nuclease; Region: ParBc_2; cl17538 398527016945 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 398527016946 putative phosphate binding site [ion binding]; other site 398527016947 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 398527016948 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 398527016949 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 398527016950 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 398527016951 S-adenosylmethionine binding site [chemical binding]; other site 398527016952 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 398527016953 NAD(P) binding site [chemical binding]; other site 398527016954 Phasin protein; Region: Phasin_2; pfam09361 398527016955 Transcriptional activator HlyU; Region: HlyU; cl02273 398527016956 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 398527016957 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 398527016958 metal binding site [ion binding]; metal-binding site 398527016959 active site 398527016960 I-site; other site 398527016961 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 398527016962 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 398527016963 acetylornithine deacetylase; Provisional; Region: PRK07522 398527016964 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 398527016965 metal binding site [ion binding]; metal-binding site 398527016966 putative dimer interface [polypeptide binding]; other site 398527016967 Uncharacterized conserved protein [Function unknown]; Region: COG3342 398527016968 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 398527016969 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 398527016970 homotrimer interaction site [polypeptide binding]; other site 398527016971 putative active site [active] 398527016972 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 398527016973 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 398527016974 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527016975 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527016976 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 398527016977 putative substrate binding pocket [chemical binding]; other site 398527016978 dimerization interface [polypeptide binding]; other site 398527016979 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 398527016980 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 398527016981 [2Fe-2S] cluster binding site [ion binding]; other site 398527016982 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_1; cd08885 398527016983 putative alpha subunit interface [polypeptide binding]; other site 398527016984 putative active site [active] 398527016985 putative substrate binding site [chemical binding]; other site 398527016986 Fe binding site [ion binding]; other site 398527016987 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 398527016988 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 398527016989 Walker A/P-loop; other site 398527016990 ATP binding site [chemical binding]; other site 398527016991 Q-loop/lid; other site 398527016992 ABC transporter signature motif; other site 398527016993 Walker B; other site 398527016994 D-loop; other site 398527016995 H-loop/switch region; other site 398527016996 TOBE domain; Region: TOBE_2; pfam08402 398527016997 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 398527016998 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527016999 dimer interface [polypeptide binding]; other site 398527017000 conserved gate region; other site 398527017001 putative PBP binding loops; other site 398527017002 ABC-ATPase subunit interface; other site 398527017003 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 398527017004 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527017005 dimer interface [polypeptide binding]; other site 398527017006 conserved gate region; other site 398527017007 putative PBP binding loops; other site 398527017008 ABC-ATPase subunit interface; other site 398527017009 type III secretion system chaperone YscW; Region: YscW; TIGR02567 398527017010 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 398527017011 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 398527017012 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527017013 enoyl-CoA hydratase; Provisional; Region: PRK06688 398527017014 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 398527017015 substrate binding site [chemical binding]; other site 398527017016 oxyanion hole (OAH) forming residues; other site 398527017017 trimer interface [polypeptide binding]; other site 398527017018 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 398527017019 CoA-transferase family III; Region: CoA_transf_3; pfam02515 398527017020 fumarylacetoacetase; Region: PLN02856 398527017021 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 398527017022 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 398527017023 Protein of unknown function, DUF485; Region: DUF485; pfam04341 398527017024 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 398527017025 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 398527017026 Na binding site [ion binding]; other site 398527017027 Domain of unknown function DUF302; Region: DUF302; pfam03625 398527017028 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 398527017029 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527017030 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 398527017031 dimerization interface [polypeptide binding]; other site 398527017032 substrate binding pocket [chemical binding]; other site 398527017033 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 398527017034 Prostaglandin dehydrogenases; Region: PGDH; cd05288 398527017035 NAD(P) binding site [chemical binding]; other site 398527017036 substrate binding site [chemical binding]; other site 398527017037 dimer interface [polypeptide binding]; other site 398527017038 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 398527017039 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 398527017040 active site 398527017041 cytosine deaminase; Provisional; Region: PRK05985 398527017042 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 398527017043 active site 398527017044 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 398527017045 Na binding site [ion binding]; other site 398527017046 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 398527017047 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527017048 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527017049 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 398527017050 dimerization interface [polypeptide binding]; other site 398527017051 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 398527017052 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 398527017053 NAD(P) binding site [chemical binding]; other site 398527017054 active site 398527017055 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527017056 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527017057 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 398527017058 putative effector binding pocket; other site 398527017059 dimerization interface [polypeptide binding]; other site 398527017060 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 398527017061 ligand binding site [chemical binding]; other site 398527017062 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 398527017063 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 398527017064 trimer interface [polypeptide binding]; other site 398527017065 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 398527017066 trimer interface [polypeptide binding]; other site 398527017067 YadA-like C-terminal region; Region: YadA; pfam03895 398527017068 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 398527017069 trimer interface [polypeptide binding]; other site 398527017070 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 398527017071 trimer interface [polypeptide binding]; other site 398527017072 YadA-like C-terminal region; Region: YadA; pfam03895 398527017073 Response regulator receiver domain; Region: Response_reg; pfam00072 398527017074 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527017075 active site 398527017076 phosphorylation site [posttranslational modification] 398527017077 intermolecular recognition site; other site 398527017078 dimerization interface [polypeptide binding]; other site 398527017079 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 398527017080 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527017081 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 398527017082 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 398527017083 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 398527017084 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 398527017085 dimer interface [polypeptide binding]; other site 398527017086 phosphorylation site [posttranslational modification] 398527017087 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527017088 ATP binding site [chemical binding]; other site 398527017089 Mg2+ binding site [ion binding]; other site 398527017090 G-X-G motif; other site 398527017091 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 398527017092 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 398527017093 N-terminal plug; other site 398527017094 ligand-binding site [chemical binding]; other site 398527017095 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 398527017096 substrate binding site [chemical binding]; other site 398527017097 OsmC-like protein; Region: OsmC; cl00767 398527017098 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527017099 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527017100 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 398527017101 putative effector binding pocket; other site 398527017102 dimerization interface [polypeptide binding]; other site 398527017103 Response regulator receiver domain; Region: Response_reg; pfam00072 398527017104 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527017105 active site 398527017106 phosphorylation site [posttranslational modification] 398527017107 intermolecular recognition site; other site 398527017108 dimerization interface [polypeptide binding]; other site 398527017109 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 398527017110 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527017111 active site 398527017112 phosphorylation site [posttranslational modification] 398527017113 intermolecular recognition site; other site 398527017114 dimerization interface [polypeptide binding]; other site 398527017115 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 398527017116 DNA binding residues [nucleotide binding] 398527017117 dimerization interface [polypeptide binding]; other site 398527017118 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 398527017119 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 398527017120 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 398527017121 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 398527017122 Herpesvirus Glycoprotein B; Region: Glycoprotein_B; pfam00606 398527017123 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 398527017124 active site residue [active] 398527017125 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 398527017126 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 398527017127 active site 398527017128 nucleophile elbow; other site 398527017129 Patatin phospholipase; Region: DUF3734; pfam12536 398527017130 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 398527017131 classical (c) SDRs; Region: SDR_c; cd05233 398527017132 NAD(P) binding site [chemical binding]; other site 398527017133 active site 398527017134 acetoacetate decarboxylase; Provisional; Region: PRK02265 398527017135 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 398527017136 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 398527017137 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527017138 putative substrate translocation pore; other site 398527017139 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527017140 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 398527017141 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 398527017142 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 398527017143 Lecithin retinol acyltransferase; Region: LRAT; pfam04970 398527017144 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 398527017145 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 398527017146 Uncharacterized conserved protein [Function unknown]; Region: COG2128 398527017147 Cupin domain; Region: Cupin_2; pfam07883 398527017148 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 398527017149 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 398527017150 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527017151 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527017152 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 398527017153 putative effector binding pocket; other site 398527017154 dimerization interface [polypeptide binding]; other site 398527017155 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 398527017156 Ca2+ binding site [ion binding]; other site 398527017157 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 398527017158 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 398527017159 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 398527017160 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 398527017161 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 398527017162 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 398527017163 putative ligand binding site [chemical binding]; other site 398527017164 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 398527017165 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 398527017166 substrate binding site [chemical binding]; other site 398527017167 activation loop (A-loop); other site 398527017168 AAA ATPase domain; Region: AAA_16; pfam13191 398527017169 Predicted ATPase [General function prediction only]; Region: COG3899 398527017170 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 398527017171 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 398527017172 PAS domain S-box; Region: sensory_box; TIGR00229 398527017173 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 398527017174 putative active site [active] 398527017175 heme pocket [chemical binding]; other site 398527017176 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 398527017177 dimer interface [polypeptide binding]; other site 398527017178 phosphorylation site [posttranslational modification] 398527017179 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527017180 ATP binding site [chemical binding]; other site 398527017181 Mg2+ binding site [ion binding]; other site 398527017182 G-X-G motif; other site 398527017183 GMP synthase; Reviewed; Region: guaA; PRK00074 398527017184 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 398527017185 AMP/PPi binding site [chemical binding]; other site 398527017186 candidate oxyanion hole; other site 398527017187 catalytic triad [active] 398527017188 potential glutamine specificity residues [chemical binding]; other site 398527017189 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 398527017190 ATP Binding subdomain [chemical binding]; other site 398527017191 Ligand Binding sites [chemical binding]; other site 398527017192 Dimerization subdomain; other site 398527017193 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 398527017194 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 398527017195 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 398527017196 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 398527017197 active site 398527017198 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 398527017199 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2914 398527017200 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 398527017201 putative coenzyme Q binding site [chemical binding]; other site 398527017202 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 398527017203 SmpB-tmRNA interface; other site 398527017204 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 398527017205 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 398527017206 phosphoenolpyruvate synthase; Validated; Region: PRK06464 398527017207 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 398527017208 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 398527017209 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 398527017210 PEP synthetase regulatory protein; Provisional; Region: PRK05339 398527017211 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 398527017212 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 398527017213 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 398527017214 RNA/DNA hybrid binding site [nucleotide binding]; other site 398527017215 active site 398527017216 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 398527017217 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 398527017218 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 398527017219 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 398527017220 active site 398527017221 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 398527017222 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 398527017223 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 398527017224 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 398527017225 trimer interface [polypeptide binding]; other site 398527017226 active site 398527017227 UDP-GlcNAc binding site [chemical binding]; other site 398527017228 lipid binding site [chemical binding]; lipid-binding site 398527017229 periplasmic chaperone; Provisional; Region: PRK10780 398527017230 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 398527017231 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 398527017232 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 398527017233 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 398527017234 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 398527017235 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 398527017236 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 398527017237 Surface antigen; Region: Bac_surface_Ag; pfam01103 398527017238 zinc metallopeptidase RseP; Provisional; Region: PRK10779 398527017239 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 398527017240 active site 398527017241 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 398527017242 protein binding site [polypeptide binding]; other site 398527017243 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 398527017244 putative substrate binding region [chemical binding]; other site 398527017245 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 398527017246 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 398527017247 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 398527017248 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 398527017249 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 398527017250 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 398527017251 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14836 398527017252 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 398527017253 catalytic residue [active] 398527017254 putative FPP diphosphate binding site; other site 398527017255 putative FPP binding hydrophobic cleft; other site 398527017256 dimer interface [polypeptide binding]; other site 398527017257 putative IPP diphosphate binding site; other site 398527017258 ribosome recycling factor; Reviewed; Region: frr; PRK00083 398527017259 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 398527017260 hinge region; other site 398527017261 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 398527017262 putative nucleotide binding site [chemical binding]; other site 398527017263 uridine monophosphate binding site [chemical binding]; other site 398527017264 homohexameric interface [polypeptide binding]; other site 398527017265 elongation factor Ts; Provisional; Region: tsf; PRK09377 398527017266 UBA/TS-N domain; Region: UBA; pfam00627 398527017267 Elongation factor TS; Region: EF_TS; pfam00889 398527017268 Elongation factor TS; Region: EF_TS; pfam00889 398527017269 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 398527017270 rRNA interaction site [nucleotide binding]; other site 398527017271 S8 interaction site; other site 398527017272 putative laminin-1 binding site; other site 398527017273 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 398527017274 active site 398527017275 PII uridylyl-transferase; Provisional; Region: PRK03059 398527017276 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 398527017277 metal binding triad; other site 398527017278 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 398527017279 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 398527017280 Zn2+ binding site [ion binding]; other site 398527017281 Mg2+ binding site [ion binding]; other site 398527017282 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 398527017283 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 398527017284 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 398527017285 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 398527017286 RNA binding surface [nucleotide binding]; other site 398527017287 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 398527017288 active site 398527017289 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 398527017290 active site 398527017291 catalytic residues [active] 398527017292 metal binding site [ion binding]; metal-binding site 398527017293 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 398527017294 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 398527017295 nucleotide binding pocket [chemical binding]; other site 398527017296 K-X-D-G motif; other site 398527017297 catalytic site [active] 398527017298 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 398527017299 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 398527017300 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 398527017301 Dimer interface [polypeptide binding]; other site 398527017302 BRCT sequence motif; other site 398527017303 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 398527017304 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 398527017305 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 398527017306 Walker A/P-loop; other site 398527017307 ATP binding site [chemical binding]; other site 398527017308 Q-loop/lid; other site 398527017309 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 398527017310 Q-loop/lid; other site 398527017311 ABC transporter signature motif; other site 398527017312 Walker B; other site 398527017313 D-loop; other site 398527017314 H-loop/switch region; other site 398527017315 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 398527017316 EamA-like transporter family; Region: EamA; pfam00892 398527017317 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 398527017318 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 398527017319 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527017320 homodimer interface [polypeptide binding]; other site 398527017321 catalytic residue [active] 398527017322 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 398527017323 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 398527017324 trimer interface [polypeptide binding]; other site 398527017325 active site 398527017326 substrate binding site [chemical binding]; other site 398527017327 CoA binding site [chemical binding]; other site 398527017328 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 398527017329 ArsC family; Region: ArsC; pfam03960 398527017330 putative catalytic residues [active] 398527017331 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 398527017332 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 398527017333 metal binding site [ion binding]; metal-binding site 398527017334 dimer interface [polypeptide binding]; other site 398527017335 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 398527017336 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 398527017337 S-adenosylmethionine binding site [chemical binding]; other site 398527017338 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 398527017339 Putative catalytic domain, repeat 1, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_1; cd09155 398527017340 putative active site [active] 398527017341 catalytic site [active] 398527017342 Putative catalytic domain, repeat 2, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_2; cd09161 398527017343 putative active site [active] 398527017344 catalytic site [active] 398527017345 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 398527017346 catalytic residues [active] 398527017347 dimer interface [polypeptide binding]; other site 398527017348 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 398527017349 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 398527017350 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 398527017351 ABC transporter; Region: ABC_tran_2; pfam12848 398527017352 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 398527017353 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 398527017354 CoA-transferase family III; Region: CoA_transf_3; pfam02515 398527017355 Protein of unknown function (DUF2866); Region: DUF2866; pfam11065 398527017356 DNA repair protein RadA; Provisional; Region: PRK11823 398527017357 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 398527017358 Walker A motif/ATP binding site; other site 398527017359 ATP binding site [chemical binding]; other site 398527017360 Walker B motif; other site 398527017361 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 398527017362 alanine racemase; Reviewed; Region: alr; PRK00053 398527017363 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 398527017364 active site 398527017365 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 398527017366 substrate binding site [chemical binding]; other site 398527017367 catalytic residues [active] 398527017368 dimer interface [polypeptide binding]; other site 398527017369 lysophospholipid transporter LplT; Provisional; Region: PRK11195 398527017370 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 398527017371 dimer interface [polypeptide binding]; other site 398527017372 substrate binding site [chemical binding]; other site 398527017373 ATP binding site [chemical binding]; other site 398527017374 Domain of unknown function (DUF1853); Region: DUF1853; pfam08907 398527017375 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 398527017376 Fe-S cluster binding site [ion binding]; other site 398527017377 active site 398527017378 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 398527017379 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 398527017380 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 398527017381 Glycoprotease family; Region: Peptidase_M22; pfam00814 398527017382 Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a...; Region: ACBP; cl00221 398527017383 acyl-CoA binding pocket [chemical binding]; other site 398527017384 CoA binding site [chemical binding]; other site 398527017385 helicase 45; Provisional; Region: PTZ00424 398527017386 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 398527017387 ATP binding site [chemical binding]; other site 398527017388 Mg++ binding site [ion binding]; other site 398527017389 motif III; other site 398527017390 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 398527017391 nucleotide binding region [chemical binding]; other site 398527017392 ATP-binding site [chemical binding]; other site 398527017393 isocitrate lyase; Provisional; Region: PRK15063 398527017394 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 398527017395 tetramer interface [polypeptide binding]; other site 398527017396 active site 398527017397 Mg2+/Mn2+ binding site [ion binding]; other site 398527017398 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 398527017399 Ligand Binding Site [chemical binding]; other site 398527017400 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527017401 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527017402 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 398527017403 putative effector binding pocket; other site 398527017404 dimerization interface [polypeptide binding]; other site 398527017405 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 398527017406 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 398527017407 motif II; other site 398527017408 malate synthase A; Region: malate_syn_A; TIGR01344 398527017409 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 398527017410 active site 398527017411 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 398527017412 putative active site pocket [active] 398527017413 dimerization interface [polypeptide binding]; other site 398527017414 putative catalytic residue [active] 398527017415 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 398527017416 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 398527017417 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 398527017418 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527017419 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527017420 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 398527017421 Coenzyme A binding pocket [chemical binding]; other site 398527017422 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 398527017423 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 398527017424 active site 398527017425 HIGH motif; other site 398527017426 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 398527017427 active site 398527017428 KMSKS motif; other site 398527017429 hypothetical protein; Provisional; Region: PRK10279 398527017430 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 398527017431 nucleophile elbow; other site 398527017432 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 398527017433 NlpC/P60 family; Region: NLPC_P60; pfam00877 398527017434 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 398527017435 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 398527017436 Walker A/P-loop; other site 398527017437 ATP binding site [chemical binding]; other site 398527017438 Q-loop/lid; other site 398527017439 ABC transporter signature motif; other site 398527017440 Walker B; other site 398527017441 D-loop; other site 398527017442 H-loop/switch region; other site 398527017443 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 398527017444 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 398527017445 Walker A/P-loop; other site 398527017446 ATP binding site [chemical binding]; other site 398527017447 Q-loop/lid; other site 398527017448 ABC transporter signature motif; other site 398527017449 Walker B; other site 398527017450 D-loop; other site 398527017451 H-loop/switch region; other site 398527017452 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 398527017453 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 398527017454 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 398527017455 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527017456 dimer interface [polypeptide binding]; other site 398527017457 conserved gate region; other site 398527017458 putative PBP binding loops; other site 398527017459 ABC-ATPase subunit interface; other site 398527017460 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 398527017461 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527017462 dimer interface [polypeptide binding]; other site 398527017463 conserved gate region; other site 398527017464 putative PBP binding loops; other site 398527017465 ABC-ATPase subunit interface; other site 398527017466 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 398527017467 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 398527017468 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 398527017469 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06997 398527017470 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 398527017471 NAD binding site [chemical binding]; other site 398527017472 homotetramer interface [polypeptide binding]; other site 398527017473 homodimer interface [polypeptide binding]; other site 398527017474 substrate binding site [chemical binding]; other site 398527017475 active site 398527017476 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 398527017477 Amidohydrolase; Region: Amidohydro_2; pfam04909 398527017478 aspartate kinase; Reviewed; Region: PRK06635 398527017479 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 398527017480 putative nucleotide binding site [chemical binding]; other site 398527017481 putative catalytic residues [active] 398527017482 putative Mg ion binding site [ion binding]; other site 398527017483 putative aspartate binding site [chemical binding]; other site 398527017484 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 398527017485 putative allosteric regulatory site; other site 398527017486 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 398527017487 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 398527017488 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 398527017489 Ligand Binding Site [chemical binding]; other site 398527017490 TilS substrate binding domain; Region: TilS; pfam09179 398527017491 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 398527017492 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 398527017493 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 398527017494 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 398527017495 endonuclease III; Region: ENDO3c; smart00478 398527017496 minor groove reading motif; other site 398527017497 helix-hairpin-helix signature motif; other site 398527017498 substrate binding pocket [chemical binding]; other site 398527017499 active site 398527017500 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 398527017501 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 398527017502 active site 398527017503 HIGH motif; other site 398527017504 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 398527017505 KMSKS motif; other site 398527017506 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 398527017507 tRNA binding surface [nucleotide binding]; other site 398527017508 anticodon binding site; other site 398527017509 TPR repeat; Region: TPR_11; pfam13414 398527017510 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 398527017511 binding surface 398527017512 TPR motif; other site 398527017513 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 398527017514 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 398527017515 substrate binding site [chemical binding]; other site 398527017516 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 398527017517 substrate binding site [chemical binding]; other site 398527017518 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 398527017519 putative active site [active] 398527017520 putative metal binding site [ion binding]; other site 398527017521 serine O-acetyltransferase; Region: cysE; TIGR01172 398527017522 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 398527017523 trimer interface [polypeptide binding]; other site 398527017524 active site 398527017525 substrate binding site [chemical binding]; other site 398527017526 CoA binding site [chemical binding]; other site 398527017527 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 398527017528 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 398527017529 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 398527017530 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 398527017531 active site 398527017532 dimerization interface [polypeptide binding]; other site 398527017533 lysophospholipid transporter LplT; Provisional; Region: PRK11195 398527017534 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 398527017535 MutS domain I; Region: MutS_I; pfam01624 398527017536 MutS domain II; Region: MutS_II; pfam05188 398527017537 MutS domain III; Region: MutS_III; pfam05192 398527017538 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 398527017539 Walker A/P-loop; other site 398527017540 ATP binding site [chemical binding]; other site 398527017541 Q-loop/lid; other site 398527017542 ABC transporter signature motif; other site 398527017543 Walker B; other site 398527017544 D-loop; other site 398527017545 H-loop/switch region; other site 398527017546 large tegument protein UL36; Provisional; Region: PHA03247 398527017547 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 398527017548 Uncharacterized conserved protein [Function unknown]; Region: COG2850 398527017549 Cupin-like domain; Region: Cupin_8; pfam13621 398527017550 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 398527017551 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 398527017552 DEAD_2; Region: DEAD_2; pfam06733 398527017553 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 398527017554 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 398527017555 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 398527017556 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 398527017557 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 398527017558 RNA binding site [nucleotide binding]; other site 398527017559 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 398527017560 potassium uptake protein; Region: kup; TIGR00794 398527017561 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 398527017562 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 398527017563 active site 398527017564 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 398527017565 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 398527017566 GDP-binding site [chemical binding]; other site 398527017567 ACT binding site; other site 398527017568 IMP binding site; other site 398527017569 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: PRK12421 398527017570 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 398527017571 dimer interface [polypeptide binding]; other site 398527017572 motif 1; other site 398527017573 active site 398527017574 motif 2; other site 398527017575 motif 3; other site 398527017576 Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838 398527017577 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 398527017578 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 398527017579 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 398527017580 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 398527017581 HflK protein; Region: hflK; TIGR01933 398527017582 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 398527017583 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 398527017584 HflX GTPase family; Region: HflX; cd01878 398527017585 G1 box; other site 398527017586 GTP/Mg2+ binding site [chemical binding]; other site 398527017587 Switch I region; other site 398527017588 G2 box; other site 398527017589 G3 box; other site 398527017590 Switch II region; other site 398527017591 G4 box; other site 398527017592 G5 box; other site 398527017593 bacterial Hfq-like; Region: Hfq; cd01716 398527017594 hexamer interface [polypeptide binding]; other site 398527017595 Sm1 motif; other site 398527017596 RNA binding site [nucleotide binding]; other site 398527017597 Sm2 motif; other site 398527017598 GTP-binding protein Der; Reviewed; Region: PRK00093 398527017599 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 398527017600 G1 box; other site 398527017601 GTP/Mg2+ binding site [chemical binding]; other site 398527017602 Switch I region; other site 398527017603 G2 box; other site 398527017604 Switch II region; other site 398527017605 G3 box; other site 398527017606 G4 box; other site 398527017607 G5 box; other site 398527017608 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 398527017609 G1 box; other site 398527017610 GTP/Mg2+ binding site [chemical binding]; other site 398527017611 Switch I region; other site 398527017612 G2 box; other site 398527017613 G3 box; other site 398527017614 Switch II region; other site 398527017615 G4 box; other site 398527017616 G5 box; other site 398527017617 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 398527017618 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 398527017619 Trp docking motif [polypeptide binding]; other site 398527017620 active site 398527017621 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 398527017622 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 398527017623 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 398527017624 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 398527017625 dimer interface [polypeptide binding]; other site 398527017626 motif 1; other site 398527017627 active site 398527017628 motif 2; other site 398527017629 motif 3; other site 398527017630 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 398527017631 anticodon binding site; other site 398527017632 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 398527017633 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 398527017634 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 398527017635 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 398527017636 non-specific DNA binding site [nucleotide binding]; other site 398527017637 salt bridge; other site 398527017638 sequence-specific DNA binding site [nucleotide binding]; other site 398527017639 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 398527017640 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 398527017641 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 398527017642 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 398527017643 FeS/SAM binding site; other site 398527017644 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 398527017645 active site 398527017646 multimer interface [polypeptide binding]; other site 398527017647 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 398527017648 YccA-like proteins; Region: YccA_like; cd10433 398527017649 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 398527017650 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 398527017651 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 398527017652 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 398527017653 dihydrodipicolinate synthase; Region: dapA; TIGR00674 398527017654 dimer interface [polypeptide binding]; other site 398527017655 active site 398527017656 catalytic residue [active] 398527017657 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 398527017658 S-adenosylmethionine binding site [chemical binding]; other site 398527017659 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 398527017660 active site 398527017661 HIGH motif; other site 398527017662 dimer interface [polypeptide binding]; other site 398527017663 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 398527017664 active site 398527017665 KMSKS motif; other site 398527017666 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 398527017667 Peptidase family M50; Region: Peptidase_M50; pfam02163 398527017668 active site 398527017669 putative substrate binding region [chemical binding]; other site 398527017670 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 398527017671 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 398527017672 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 398527017673 active site 398527017674 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 398527017675 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 398527017676 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 398527017677 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 398527017678 catalytic site [active] 398527017679 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 398527017680 dinuclear metal binding motif [ion binding]; other site 398527017681 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 398527017682 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 398527017683 trimer interface [polypeptide binding]; other site 398527017684 putative metal binding site [ion binding]; other site 398527017685 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 398527017686 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 398527017687 dimerization interface [polypeptide binding]; other site 398527017688 domain crossover interface; other site 398527017689 redox-dependent activation switch; other site 398527017690 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 398527017691 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 398527017692 enolase; Provisional; Region: eno; PRK00077 398527017693 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 398527017694 dimer interface [polypeptide binding]; other site 398527017695 metal binding site [ion binding]; metal-binding site 398527017696 substrate binding pocket [chemical binding]; other site 398527017697 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 398527017698 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 398527017699 CTP synthetase; Validated; Region: pyrG; PRK05380 398527017700 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 398527017701 Catalytic site [active] 398527017702 active site 398527017703 UTP binding site [chemical binding]; other site 398527017704 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 398527017705 active site 398527017706 putative oxyanion hole; other site 398527017707 catalytic triad [active] 398527017708 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 398527017709 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 398527017710 nucleophilic elbow; other site 398527017711 catalytic triad; other site 398527017712 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 398527017713 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 398527017714 Competence protein; Region: Competence; pfam03772 398527017715 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 398527017716 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 398527017717 active site 398527017718 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 398527017719 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 398527017720 Walker A/P-loop; other site 398527017721 ATP binding site [chemical binding]; other site 398527017722 Q-loop/lid; other site 398527017723 ABC transporter signature motif; other site 398527017724 Walker B; other site 398527017725 D-loop; other site 398527017726 H-loop/switch region; other site 398527017727 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 398527017728 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 398527017729 FtsX-like permease family; Region: FtsX; pfam02687 398527017730 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4255 398527017731 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 398527017732 DHH family; Region: DHH; pfam01368 398527017733 peptide chain release factor 2; Validated; Region: prfB; PRK00578 398527017734 This domain is found in peptide chain release factors; Region: PCRF; smart00937 398527017735 RF-1 domain; Region: RF-1; pfam00472 398527017736 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 398527017737 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 398527017738 dimer interface [polypeptide binding]; other site 398527017739 putative anticodon binding site; other site 398527017740 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 398527017741 motif 1; other site 398527017742 active site 398527017743 motif 2; other site 398527017744 motif 3; other site 398527017745 Iron-sulphur cluster assembly; Region: Fe-S_assembly; pfam04384 398527017746 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 398527017747 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 398527017748 catalytic loop [active] 398527017749 iron binding site [ion binding]; other site 398527017750 chaperone protein HscA; Provisional; Region: hscA; PRK05183 398527017751 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 398527017752 nucleotide binding site [chemical binding]; other site 398527017753 putative NEF/HSP70 interaction site [polypeptide binding]; other site 398527017754 SBD interface [polypeptide binding]; other site 398527017755 co-chaperone HscB; Provisional; Region: hscB; PRK03578 398527017756 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 398527017757 HSP70 interaction site [polypeptide binding]; other site 398527017758 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 398527017759 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 398527017760 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 398527017761 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 398527017762 trimerization site [polypeptide binding]; other site 398527017763 active site 398527017764 cysteine desulfurase; Provisional; Region: PRK14012 398527017765 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 398527017766 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 398527017767 catalytic residue [active] 398527017768 Predicted transcriptional regulator [Transcription]; Region: COG1959 398527017769 iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010 398527017770 Low molecular weight phosphatase family; Region: LMWPc; cd00115 398527017771 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 398527017772 active site 398527017773 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 398527017774 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 398527017775 4Fe-4S binding domain; Region: Fer4; pfam00037 398527017776 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 398527017777 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 398527017778 Cysteine-rich domain; Region: CCG; pfam02754 398527017779 Cysteine-rich domain; Region: CCG; pfam02754 398527017780 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 398527017781 Transcriptional regulator [Transcription]; Region: IclR; COG1414 398527017782 Bacterial transcriptional regulator; Region: IclR; pfam01614 398527017783 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 398527017784 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 398527017785 Phasin protein; Region: Phasin_2; pfam09361 398527017786 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 398527017787 E3 interaction surface; other site 398527017788 lipoyl attachment site [posttranslational modification]; other site 398527017789 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 398527017790 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 398527017791 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 398527017792 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 398527017793 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 398527017794 E3 interaction surface; other site 398527017795 lipoyl attachment site [posttranslational modification]; other site 398527017796 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 398527017797 E3 interaction surface; other site 398527017798 lipoyl attachment site [posttranslational modification]; other site 398527017799 e3 binding domain; Region: E3_binding; pfam02817 398527017800 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 398527017801 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 398527017802 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 398527017803 dimer interface [polypeptide binding]; other site 398527017804 TPP-binding site [chemical binding]; other site 398527017805 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 398527017806 PAS domain S-box; Region: sensory_box; TIGR00229 398527017807 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 398527017808 putative active site [active] 398527017809 heme pocket [chemical binding]; other site 398527017810 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 398527017811 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 398527017812 dimer interface [polypeptide binding]; other site 398527017813 phosphorylation site [posttranslational modification] 398527017814 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527017815 ATP binding site [chemical binding]; other site 398527017816 Mg2+ binding site [ion binding]; other site 398527017817 G-X-G motif; other site 398527017818 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 398527017819 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527017820 active site 398527017821 phosphorylation site [posttranslational modification] 398527017822 intermolecular recognition site; other site 398527017823 dimerization interface [polypeptide binding]; other site 398527017824 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 398527017825 DNA binding residues [nucleotide binding] 398527017826 dimerization interface [polypeptide binding]; other site 398527017827 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 398527017828 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14189 398527017829 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 398527017830 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 398527017831 homodimer interface [polypeptide binding]; other site 398527017832 NADP binding site [chemical binding]; other site 398527017833 substrate binding site [chemical binding]; other site 398527017834 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 398527017835 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 398527017836 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 398527017837 active site 398527017838 Zn binding site [ion binding]; other site 398527017839 cytosine deaminase; Validated; Region: PRK07572 398527017840 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 398527017841 active site 398527017842 aspartate racemase; Region: asp_race; TIGR00035 398527017843 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 398527017844 nascent polypeptide-associated complex protein; Reviewed; Region: nac; PRK06369 398527017845 Peptidase M35-like domain of uncharacterized proteins; Region: M35_like_1; cd11007 398527017846 putative active site [active] 398527017847 putative Zn binding site [ion binding]; other site 398527017848 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 398527017849 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 398527017850 HTH-like domain; Region: HTH_21; pfam13276 398527017851 Integrase core domain; Region: rve; pfam00665 398527017852 Integrase core domain; Region: rve_3; pfam13683 398527017853 Transposase; Region: HTH_Tnp_1; cl17663 398527017854 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 398527017855 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 398527017856 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 398527017857 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 398527017858 putative catalytic site [active] 398527017859 putative phosphate binding site [ion binding]; other site 398527017860 active site 398527017861 metal binding site A [ion binding]; metal-binding site 398527017862 DNA binding site [nucleotide binding] 398527017863 putative AP binding site [nucleotide binding]; other site 398527017864 putative metal binding site B [ion binding]; other site 398527017865 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 398527017866 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 398527017867 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 398527017868 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527017869 active site 398527017870 phosphorylation site [posttranslational modification] 398527017871 intermolecular recognition site; other site 398527017872 dimerization interface [polypeptide binding]; other site 398527017873 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527017874 Walker A motif; other site 398527017875 ATP binding site [chemical binding]; other site 398527017876 Walker B motif; other site 398527017877 arginine finger; other site 398527017878 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 398527017879 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 398527017880 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 398527017881 dimer interface [polypeptide binding]; other site 398527017882 phosphorylation site [posttranslational modification] 398527017883 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527017884 ATP binding site [chemical binding]; other site 398527017885 Mg2+ binding site [ion binding]; other site 398527017886 G-X-G motif; other site 398527017887 glutamine synthetase; Provisional; Region: glnA; PRK09469 398527017888 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 398527017889 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 398527017890 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 398527017891 active site residue [active] 398527017892 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 398527017893 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 398527017894 putative MPT binding site; other site 398527017895 Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264 398527017896 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 398527017897 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 398527017898 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 398527017899 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 398527017900 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 398527017901 trimer interface [polypeptide binding]; other site 398527017902 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 398527017903 trimer interface [polypeptide binding]; other site 398527017904 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 398527017905 Haemagglutinin; Region: HIM; pfam05662 398527017906 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 398527017907 trimer interface [polypeptide binding]; other site 398527017908 Haemagglutinin; Region: HIM; pfam05662 398527017909 YadA-like C-terminal region; Region: YadA; pfam03895 398527017910 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 398527017911 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 398527017912 ATP binding site [chemical binding]; other site 398527017913 putative Mg++ binding site [ion binding]; other site 398527017914 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 398527017915 nucleotide binding region [chemical binding]; other site 398527017916 ATP-binding site [chemical binding]; other site 398527017917 Helicase associated domain (HA2); Region: HA2; pfam04408 398527017918 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 398527017919 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 398527017920 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 398527017921 N-acetylglutamate synthase; Validated; Region: PRK05279 398527017922 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 398527017923 putative feedback inhibition sensing region; other site 398527017924 putative nucleotide binding site [chemical binding]; other site 398527017925 putative substrate binding site [chemical binding]; other site 398527017926 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 398527017927 Coenzyme A binding pocket [chemical binding]; other site 398527017928 oxidative damage protection protein; Provisional; Region: PRK05408 398527017929 proline/glycine betaine transporter; Provisional; Region: PRK10642 398527017930 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527017931 putative substrate translocation pore; other site 398527017932 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 398527017933 active site 398527017934 metal binding site [ion binding]; metal-binding site 398527017935 homotetramer interface [polypeptide binding]; other site 398527017936 Predicted integral membrane protein [Function unknown]; Region: COG3548 398527017937 nif11 domain/cupin domain protein; Region: nif11_cupin; TIGR03890 398527017938 mercuric reductase; Validated; Region: PRK06370 398527017939 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 398527017940 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 398527017941 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 398527017942 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 398527017943 GAF domain; Region: GAF; pfam01590 398527017944 PAS fold; Region: PAS; pfam00989 398527017945 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 398527017946 putative active site [active] 398527017947 heme pocket [chemical binding]; other site 398527017948 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 398527017949 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 398527017950 metal binding site [ion binding]; metal-binding site 398527017951 active site 398527017952 I-site; other site 398527017953 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 398527017954 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 398527017955 Bacterial SH3 domain; Region: SH3_3; pfam08239 398527017956 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 398527017957 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 398527017958 nucleoside/Zn binding site; other site 398527017959 dimer interface [polypeptide binding]; other site 398527017960 catalytic motif [active] 398527017961 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 398527017962 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 398527017963 putative ligand binding site [chemical binding]; other site 398527017964 short chain dehydrogenase; Provisional; Region: PRK06500 398527017965 classical (c) SDRs; Region: SDR_c; cd05233 398527017966 NAD(P) binding site [chemical binding]; other site 398527017967 active site 398527017968 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 398527017969 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 398527017970 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527017971 DNA-binding site [nucleotide binding]; DNA binding site 398527017972 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 398527017973 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527017974 homodimer interface [polypeptide binding]; other site 398527017975 catalytic residue [active] 398527017976 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 398527017977 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 398527017978 putative molybdopterin cofactor binding site [chemical binding]; other site 398527017979 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 398527017980 putative molybdopterin cofactor binding site; other site 398527017981 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 398527017982 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 398527017983 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 398527017984 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 398527017985 Transcriptional regulators [Transcription]; Region: PurR; COG1609 398527017986 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 398527017987 DNA binding site [nucleotide binding] 398527017988 domain linker motif; other site 398527017989 Ligand-binding domain of putative DNA transcription repressors highly similar to that of the repressor specific for gluconate (GntR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_2; cd06282 398527017990 putative dimerization interface [polypeptide binding]; other site 398527017991 putative ligand binding site [chemical binding]; other site 398527017992 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 398527017993 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 398527017994 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 398527017995 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527017996 dimer interface [polypeptide binding]; other site 398527017997 conserved gate region; other site 398527017998 ABC-ATPase subunit interface; other site 398527017999 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 398527018000 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527018001 dimer interface [polypeptide binding]; other site 398527018002 conserved gate region; other site 398527018003 putative PBP binding loops; other site 398527018004 ABC-ATPase subunit interface; other site 398527018005 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 398527018006 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 398527018007 Walker A/P-loop; other site 398527018008 ATP binding site [chemical binding]; other site 398527018009 Q-loop/lid; other site 398527018010 ABC transporter signature motif; other site 398527018011 Walker B; other site 398527018012 D-loop; other site 398527018013 H-loop/switch region; other site 398527018014 TOBE domain; Region: TOBE_2; pfam08402 398527018015 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 398527018016 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 398527018017 active site 398527018018 metal binding site [ion binding]; metal-binding site 398527018019 hexamer interface [polypeptide binding]; other site 398527018020 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 398527018021 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 398527018022 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527018023 Response regulator receiver domain; Region: Response_reg; pfam00072 398527018024 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527018025 active site 398527018026 phosphorylation site [posttranslational modification] 398527018027 intermolecular recognition site; other site 398527018028 dimerization interface [polypeptide binding]; other site 398527018029 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 398527018030 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527018031 active site 398527018032 phosphorylation site [posttranslational modification] 398527018033 intermolecular recognition site; other site 398527018034 dimerization interface [polypeptide binding]; other site 398527018035 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 398527018036 DNA binding residues [nucleotide binding] 398527018037 dimerization interface [polypeptide binding]; other site 398527018038 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 398527018039 Ferritin-like domain; Region: Ferritin; pfam00210 398527018040 dinuclear metal binding motif [ion binding]; other site 398527018041 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 398527018042 Histidine kinase; Region: HisKA_3; pfam07730 398527018043 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527018044 ATP binding site [chemical binding]; other site 398527018045 Mg2+ binding site [ion binding]; other site 398527018046 G-X-G motif; other site 398527018047 Entericidin EcnA/B family; Region: Entericidin; cl02322 398527018048 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 398527018049 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 398527018050 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 398527018051 active site 398527018052 FMN binding site [chemical binding]; other site 398527018053 2,4-decadienoyl-CoA binding site; other site 398527018054 catalytic residue [active] 398527018055 4Fe-4S cluster binding site [ion binding]; other site 398527018056 NADH(P)-binding; Region: NAD_binding_10; pfam13460 398527018057 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 398527018058 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 398527018059 EamA-like transporter family; Region: EamA; pfam00892 398527018060 EamA-like transporter family; Region: EamA; pfam00892 398527018061 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 398527018062 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 398527018063 Moco binding site; other site 398527018064 metal coordination site [ion binding]; other site 398527018065 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 398527018066 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 398527018067 Protein of unknown function (DUF1223); Region: DUF1223; pfam06764 398527018068 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 398527018069 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 398527018070 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 398527018071 ThiC-associated domain; Region: ThiC-associated; pfam13667 398527018072 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 398527018073 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 398527018074 L-lactate permease; Region: Lactate_perm; cl00701 398527018075 EamA-like transporter family; Region: EamA; pfam00892 398527018076 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 398527018077 EamA-like transporter family; Region: EamA; pfam00892 398527018078 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 398527018079 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 398527018080 Protein of unknown function (DUF2844); Region: DUF2844; pfam11005 398527018081 Protein of unknown function (DUF3443); Region: DUF3443; pfam11925 398527018082 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 398527018083 Predicted methyltransferase [General function prediction only]; Region: COG4798 398527018084 Methyltransferase domain; Region: Methyltransf_23; pfam13489 398527018085 2-isopropylmalate synthase; Validated; Region: PRK03739 398527018086 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 398527018087 active site 398527018088 catalytic residues [active] 398527018089 metal binding site [ion binding]; metal-binding site 398527018090 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 398527018091 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 398527018092 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 398527018093 Walker A/P-loop; other site 398527018094 ATP binding site [chemical binding]; other site 398527018095 Q-loop/lid; other site 398527018096 ABC transporter signature motif; other site 398527018097 Walker B; other site 398527018098 D-loop; other site 398527018099 H-loop/switch region; other site 398527018100 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 398527018101 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527018102 dimer interface [polypeptide binding]; other site 398527018103 conserved gate region; other site 398527018104 putative PBP binding loops; other site 398527018105 ABC-ATPase subunit interface; other site 398527018106 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 398527018107 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 398527018108 substrate binding pocket [chemical binding]; other site 398527018109 membrane-bound complex binding site; other site 398527018110 hinge residues; other site 398527018111 phenylhydantoinase; Validated; Region: PRK08323 398527018112 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 398527018113 tetramer interface [polypeptide binding]; other site 398527018114 active site 398527018115 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 398527018116 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 398527018117 Na binding site [ion binding]; other site 398527018118 putative substrate binding site [chemical binding]; other site 398527018119 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 398527018120 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 398527018121 homodimer interface [polypeptide binding]; other site 398527018122 active site 398527018123 FMN binding site [chemical binding]; other site 398527018124 substrate binding site [chemical binding]; other site 398527018125 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 398527018126 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 398527018127 allantoate amidohydrolase; Reviewed; Region: PRK09290 398527018128 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 398527018129 active site 398527018130 metal binding site [ion binding]; metal-binding site 398527018131 dimer interface [polypeptide binding]; other site 398527018132 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 398527018133 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 398527018134 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 398527018135 benzoyl-CoA oxygenase/reductase, BoxA protein; Region: benzo_boxA; TIGR03224 398527018136 4Fe-4S binding domain; Region: Fer4; pfam00037 398527018137 4Fe-4S binding domain; Region: Fer4; pfam00037 398527018138 These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208 398527018139 dimerization interface [polypeptide binding]; other site 398527018140 FAD binding pocket [chemical binding]; other site 398527018141 FAD binding motif [chemical binding]; other site 398527018142 catalytic residues [active] 398527018143 NAD binding pocket [chemical binding]; other site 398527018144 phosphate binding motif [ion binding]; other site 398527018145 beta-alpha-beta structure motif; other site 398527018146 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 398527018147 benzoyl-CoA-dihydrodiol lyase; Provisional; Region: PRK08184 398527018148 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 398527018149 substrate binding site [chemical binding]; other site 398527018150 oxyanion hole (OAH) forming residues; other site 398527018151 trimer interface [polypeptide binding]; other site 398527018152 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 398527018153 substrate binding site [chemical binding]; other site 398527018154 trimer interface [polypeptide binding]; other site 398527018155 oxyanion hole (OAH) forming residues; other site 398527018156 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 398527018157 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 398527018158 non-specific DNA binding site [nucleotide binding]; other site 398527018159 salt bridge; other site 398527018160 sequence-specific DNA binding site [nucleotide binding]; other site 398527018161 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 398527018162 Shikimate kinase; Region: SKI; pfam01202 398527018163 ADP binding site [chemical binding]; other site 398527018164 magnesium binding site [ion binding]; other site 398527018165 putative shikimate binding site; other site 398527018166 aldehyde dehydrogenase; Provisional; Region: PRK11903 398527018167 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 398527018168 substrate binding site [chemical binding]; other site 398527018169 dimer interface [polypeptide binding]; other site 398527018170 NADP binding site [chemical binding]; other site 398527018171 catalytic residues [active] 398527018172 Benzoate CoA ligase (BCL) and 4-Hydroxybenzoate-Coenzyme A Ligase (4-HBA-CoA ligase); Region: BCL_4HBCL; cd05959 398527018173 benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262 398527018174 dimer interface [polypeptide binding]; other site 398527018175 acyl-activating enzyme (AAE) consensus motif; other site 398527018176 putative active site [active] 398527018177 putative AMP binding site [chemical binding]; other site 398527018178 putative CoA binding site [chemical binding]; other site 398527018179 chemical substrate binding site [chemical binding]; other site 398527018180 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 398527018181 fructuronate transporter; Provisional; Region: PRK10034; cl15264 398527018182 GntP family permease; Region: GntP_permease; pfam02447 398527018183 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 398527018184 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 398527018185 trimer interface [polypeptide binding]; other site 398527018186 eyelet of channel; other site 398527018187 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 398527018188 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 398527018189 catalytic residue [active] 398527018190 Transcriptional regulator [Transcription]; Region: IclR; COG1414 398527018191 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 398527018192 Bacterial transcriptional regulator; Region: IclR; pfam01614 398527018193 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 398527018194 homotrimer interaction site [polypeptide binding]; other site 398527018195 putative active site [active] 398527018196 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 398527018197 Phosphoesterase family; Region: Phosphoesterase; pfam04185 398527018198 Domain of unknown function (DUF756); Region: DUF756; pfam05506 398527018199 Domain of unknown function (DUF756); Region: DUF756; pfam05506 398527018200 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 398527018201 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 398527018202 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 398527018203 MSMEG_0570 family protein; Region: MSMEG_0570_fam; TIGR04042 398527018204 AIR synthase-related protein, sll0787 family; Region: AIR_rel_sll0787; TIGR04049 398527018205 AIR synthase (PurM) related protein, subgroup 3 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like3; cd02192 398527018206 dimerization interface [polypeptide binding]; other site 398527018207 putative ATP binding site [chemical binding]; other site 398527018208 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 398527018209 Coenzyme A binding pocket [chemical binding]; other site 398527018210 radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043 398527018211 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 398527018212 FeS/SAM binding site; other site 398527018213 Predicted amidohydrolase [General function prediction only]; Region: COG0388 398527018214 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 398527018215 putative active site [active] 398527018216 catalytic triad [active] 398527018217 putative dimer interface [polypeptide binding]; other site 398527018218 MSMEG_0572 family protein; Region: MSMEG_0572_fam; TIGR04044 398527018219 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 398527018220 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527018221 DNA-binding site [nucleotide binding]; DNA binding site 398527018222 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 398527018223 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527018224 homodimer interface [polypeptide binding]; other site 398527018225 catalytic residue [active] 398527018226 Cache domain; Region: Cache_1; pfam02743 398527018227 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 398527018228 dimerization interface [polypeptide binding]; other site 398527018229 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 398527018230 dimer interface [polypeptide binding]; other site 398527018231 putative CheW interface [polypeptide binding]; other site 398527018232 HAMP domain; Region: HAMP; pfam00672 398527018233 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 398527018234 dimer interface [polypeptide binding]; other site 398527018235 putative CheW interface [polypeptide binding]; other site 398527018236 Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis [General function prediction only]; Region: COG4321 398527018237 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 398527018238 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 398527018239 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 398527018240 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 398527018241 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 398527018242 dimer interface [polypeptide binding]; other site 398527018243 active site 398527018244 metal binding site [ion binding]; metal-binding site 398527018245 glutathione binding site [chemical binding]; other site 398527018246 Protein of unknown function (DUF2000); Region: DUF2000; pfam09391 398527018247 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 398527018248 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 398527018249 putative DNA binding site [nucleotide binding]; other site 398527018250 putative Zn2+ binding site [ion binding]; other site 398527018251 AsnC family; Region: AsnC_trans_reg; pfam01037 398527018252 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 398527018253 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_3; cd05971 398527018254 active site 398527018255 acyl-activating enzyme (AAE) consensus motif; other site 398527018256 putative CoA binding site [chemical binding]; other site 398527018257 AMP binding site [chemical binding]; other site 398527018258 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 398527018259 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 398527018260 NAD(P) binding site [chemical binding]; other site 398527018261 substrate binding site [chemical binding]; other site 398527018262 homotetramer interface [polypeptide binding]; other site 398527018263 active site 398527018264 homodimer interface [polypeptide binding]; other site 398527018265 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 398527018266 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 398527018267 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 398527018268 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 398527018269 hypothetical protein; Provisional; Region: PRK14812 398527018270 substrate binding site [chemical binding]; other site 398527018271 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 398527018272 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 398527018273 substrate binding site [chemical binding]; other site 398527018274 ligand binding site [chemical binding]; other site 398527018275 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 398527018276 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527018277 transcriptional activator TtdR; Provisional; Region: PRK09801 398527018278 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 398527018279 putative effector binding pocket; other site 398527018280 putative dimerization interface [polypeptide binding]; other site 398527018281 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527018282 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527018283 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 398527018284 putative effector binding pocket; other site 398527018285 dimerization interface [polypeptide binding]; other site 398527018286 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 398527018287 substrate binding site [chemical binding]; other site 398527018288 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 398527018289 oxyanion hole (OAH) forming residues; other site 398527018290 trimer interface [polypeptide binding]; other site 398527018291 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 398527018292 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 398527018293 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 398527018294 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 398527018295 active site 398527018296 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 398527018297 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 398527018298 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 398527018299 active site 398527018300 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 398527018301 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 398527018302 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 398527018303 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 398527018304 heme binding site [chemical binding]; other site 398527018305 ferroxidase pore; other site 398527018306 ferroxidase diiron center [ion binding]; other site 398527018307 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 398527018308 iron-sulfur cluster [ion binding]; other site 398527018309 [2Fe-2S] cluster binding site [ion binding]; other site 398527018310 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 398527018311 Cytochrome P450; Region: p450; pfam00067 398527018312 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 398527018313 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 398527018314 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 398527018315 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 398527018316 Walker A/P-loop; other site 398527018317 ATP binding site [chemical binding]; other site 398527018318 Q-loop/lid; other site 398527018319 ABC transporter signature motif; other site 398527018320 Walker B; other site 398527018321 D-loop; other site 398527018322 H-loop/switch region; other site 398527018323 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 398527018324 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527018325 dimer interface [polypeptide binding]; other site 398527018326 conserved gate region; other site 398527018327 putative PBP binding loops; other site 398527018328 ABC-ATPase subunit interface; other site 398527018329 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 398527018330 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 398527018331 substrate binding pocket [chemical binding]; other site 398527018332 membrane-bound complex binding site; other site 398527018333 hinge residues; other site 398527018334 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 398527018335 Transcriptional regulator [Transcription]; Region: IclR; COG1414 398527018336 Bacterial transcriptional regulator; Region: IclR; pfam01614 398527018337 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 398527018338 active site 398527018339 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 398527018340 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 398527018341 DNA binding residues [nucleotide binding] 398527018342 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 398527018343 IHF dimer interface [polypeptide binding]; other site 398527018344 IHF - DNA interface [nucleotide binding]; other site 398527018345 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 398527018346 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 398527018347 putative tRNA-binding site [nucleotide binding]; other site 398527018348 B3/4 domain; Region: B3_4; pfam03483 398527018349 tRNA synthetase B5 domain; Region: B5; smart00874 398527018350 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 398527018351 dimer interface [polypeptide binding]; other site 398527018352 motif 1; other site 398527018353 motif 3; other site 398527018354 motif 2; other site 398527018355 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 398527018356 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 398527018357 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 398527018358 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 398527018359 dimer interface [polypeptide binding]; other site 398527018360 motif 1; other site 398527018361 active site 398527018362 motif 2; other site 398527018363 motif 3; other site 398527018364 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 398527018365 23S rRNA binding site [nucleotide binding]; other site 398527018366 L21 binding site [polypeptide binding]; other site 398527018367 L13 binding site [polypeptide binding]; other site 398527018368 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 398527018369 translation initiation factor IF-3; Region: infC; TIGR00168 398527018370 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 398527018371 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 398527018372 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 398527018373 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 398527018374 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 398527018375 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 398527018376 active site 398527018377 dimer interface [polypeptide binding]; other site 398527018378 motif 1; other site 398527018379 motif 2; other site 398527018380 motif 3; other site 398527018381 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 398527018382 anticodon binding site; other site 398527018383 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 398527018384 HD domain; Region: HD_4; pfam13328 398527018385 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 398527018386 synthetase active site [active] 398527018387 NTP binding site [chemical binding]; other site 398527018388 metal binding site [ion binding]; metal-binding site 398527018389 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 398527018390 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 398527018391 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 398527018392 homotrimer interaction site [polypeptide binding]; other site 398527018393 putative active site [active] 398527018394 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 398527018395 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 398527018396 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 398527018397 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 398527018398 PAS domain; Region: PAS_9; pfam13426 398527018399 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 398527018400 putative active site [active] 398527018401 heme pocket [chemical binding]; other site 398527018402 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 398527018403 DNA binding residues [nucleotide binding] 398527018404 dimerization interface [polypeptide binding]; other site 398527018405 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 398527018406 active site 398527018407 short chain dehydrogenase; Provisional; Region: PRK06949 398527018408 classical (c) SDRs; Region: SDR_c; cd05233 398527018409 NAD(P) binding site [chemical binding]; other site 398527018410 active site 398527018411 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 398527018412 hydroxyglutarate oxidase; Provisional; Region: PRK11728 398527018413 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 398527018414 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 398527018415 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 398527018416 binding surface 398527018417 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 398527018418 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 398527018419 Tetramer interface [polypeptide binding]; other site 398527018420 active site 398527018421 FMN-binding site [chemical binding]; other site 398527018422 lysophospholipid transporter LplT; Provisional; Region: PRK11195 398527018423 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527018424 putative substrate translocation pore; other site 398527018425 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 398527018426 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 398527018427 putative acyl-acceptor binding pocket; other site 398527018428 FOG: CBS domain [General function prediction only]; Region: COG0517 398527018429 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_12; cd04625 398527018430 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK08134 398527018431 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 398527018432 homodimer interface [polypeptide binding]; other site 398527018433 substrate-cofactor binding pocket; other site 398527018434 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527018435 catalytic residue [active] 398527018436 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 398527018437 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 398527018438 Protein of unknown function (DUF962); Region: DUF962; cl01879 398527018439 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 398527018440 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 398527018441 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 398527018442 Predicted membrane protein (DUF2069); Region: DUF2069; pfam09842 398527018443 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 398527018444 FAD binding domain; Region: FAD_binding_4; pfam01565 398527018445 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 398527018446 Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404 398527018447 putative active site [active] 398527018448 putative metal binding site [ion binding]; other site 398527018449 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 398527018450 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527018451 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527018452 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 398527018453 putative effector binding pocket; other site 398527018454 dimerization interface [polypeptide binding]; other site 398527018455 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 398527018456 Fusaric acid resistance protein family; Region: FUSC; pfam04632 398527018457 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 398527018458 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 398527018459 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 398527018460 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 398527018461 HlyD family secretion protein; Region: HlyD_3; pfam13437 398527018462 PAAR motif; Region: PAAR_motif; pfam05488 398527018463 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 398527018464 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 398527018465 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 398527018466 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 398527018467 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 398527018468 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 398527018469 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 398527018470 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 398527018471 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 398527018472 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 398527018473 dimer interface [polypeptide binding]; other site 398527018474 putative CheW interface [polypeptide binding]; other site 398527018475 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527018476 Major Facilitator Superfamily; Region: MFS_1; pfam07690 398527018477 putative substrate translocation pore; other site 398527018478 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 398527018479 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 398527018480 acyl-activating enzyme (AAE) consensus motif; other site 398527018481 AMP binding site [chemical binding]; other site 398527018482 active site 398527018483 CoA binding site [chemical binding]; other site 398527018484 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 398527018485 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 398527018486 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 398527018487 Part of AAA domain; Region: AAA_19; pfam13245 398527018488 Family description; Region: UvrD_C_2; pfam13538 398527018489 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 398527018490 Transposase; Region: HTH_Tnp_1; pfam01527 398527018491 putative transposase OrfB; Reviewed; Region: PHA02517 398527018492 HTH-like domain; Region: HTH_21; pfam13276 398527018493 Integrase core domain; Region: rve; pfam00665 398527018494 Integrase core domain; Region: rve_3; pfam13683 398527018495 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 398527018496 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 398527018497 HIGH motif; other site 398527018498 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 398527018499 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 398527018500 active site 398527018501 KMSKS motif; other site 398527018502 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 398527018503 tRNA binding surface [nucleotide binding]; other site 398527018504 anticodon binding site; other site 398527018505 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 398527018506 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 398527018507 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 398527018508 active site 398527018509 tetramer interface; other site 398527018510 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 398527018511 CPxP motif; other site 398527018512 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 398527018513 Transposase; Region: HTH_Tnp_1; pfam01527 398527018514 putative transposase OrfB; Reviewed; Region: PHA02517 398527018515 HTH-like domain; Region: HTH_21; pfam13276 398527018516 Integrase core domain; Region: rve; pfam00665 398527018517 Integrase core domain; Region: rve_3; pfam13683 398527018518 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 398527018519 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 398527018520 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 398527018521 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 398527018522 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 398527018523 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 398527018524 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 398527018525 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 398527018526 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 398527018527 putative active site [active] 398527018528 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 398527018529 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 398527018530 putative ligand binding site [chemical binding]; other site 398527018531 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 398527018532 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 398527018533 TM-ABC transporter signature motif; other site 398527018534 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 398527018535 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 398527018536 Walker A/P-loop; other site 398527018537 ATP binding site [chemical binding]; other site 398527018538 Q-loop/lid; other site 398527018539 ABC transporter signature motif; other site 398527018540 Walker B; other site 398527018541 D-loop; other site 398527018542 H-loop/switch region; other site 398527018543 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 398527018544 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 398527018545 substrate binding site [chemical binding]; other site 398527018546 ATP binding site [chemical binding]; other site 398527018547 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 398527018548 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 398527018549 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 398527018550 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 398527018551 PYR/PP interface [polypeptide binding]; other site 398527018552 dimer interface [polypeptide binding]; other site 398527018553 TPP binding site [chemical binding]; other site 398527018554 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 398527018555 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 398527018556 TPP-binding site [chemical binding]; other site 398527018557 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 398527018558 KduI/IolB family; Region: KduI; pfam04962 398527018559 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 398527018560 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 398527018561 Walker A/P-loop; other site 398527018562 ATP binding site [chemical binding]; other site 398527018563 Q-loop/lid; other site 398527018564 ABC transporter signature motif; other site 398527018565 Walker B; other site 398527018566 D-loop; other site 398527018567 H-loop/switch region; other site 398527018568 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 398527018569 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 398527018570 Walker A/P-loop; other site 398527018571 ATP binding site [chemical binding]; other site 398527018572 Q-loop/lid; other site 398527018573 ABC transporter signature motif; other site 398527018574 Walker B; other site 398527018575 D-loop; other site 398527018576 H-loop/switch region; other site 398527018577 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 398527018578 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 398527018579 TM-ABC transporter signature motif; other site 398527018580 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 398527018581 TM-ABC transporter signature motif; other site 398527018582 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 398527018583 active site 398527018584 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 398527018585 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 398527018586 nudix motif; other site 398527018587 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 398527018588 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 398527018589 tetramer interface [polypeptide binding]; other site 398527018590 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527018591 catalytic residue [active] 398527018592 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 398527018593 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527018594 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527018595 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 398527018596 putative dimerization interface [polypeptide binding]; other site 398527018597 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 398527018598 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 398527018599 motif 1; other site 398527018600 active site 398527018601 motif 2; other site 398527018602 motif 3; other site 398527018603 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 398527018604 DHHA1 domain; Region: DHHA1; pfam02272 398527018605 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 398527018606 CoA-transferase family III; Region: CoA_transf_3; pfam02515 398527018607 Serine hydrolase; Region: Ser_hydrolase; pfam06821 398527018608 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 398527018609 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 398527018610 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 398527018611 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 398527018612 active site 398527018613 HIGH motif; other site 398527018614 nucleotide binding site [chemical binding]; other site 398527018615 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 398527018616 KMSKS motif; other site 398527018617 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 398527018618 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 398527018619 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 398527018620 substrate binding pocket [chemical binding]; other site 398527018621 membrane-bound complex binding site; other site 398527018622 hinge residues; other site 398527018623 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 398527018624 nudix motif; other site 398527018625 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 398527018626 Phospholipase C [Cell envelope biogenesis, outer membrane]; Region: PlcC; COG3511 398527018627 acid phosphatase, Burkholderia-type; Region: acid_phos_Burk; TIGR03397 398527018628 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 398527018629 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 398527018630 Ligand Binding Site [chemical binding]; other site 398527018631 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 398527018632 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 398527018633 active site 398527018634 catalytic residues [active] 398527018635 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 398527018636 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 398527018637 Peptidase family M23; Region: Peptidase_M23; pfam01551 398527018638 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 398527018639 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 398527018640 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 398527018641 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 398527018642 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 398527018643 Protein of unknown function (DUF2288); Region: DUF2288; pfam10052 398527018644 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 398527018645 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 398527018646 Protein of unknown function (DUF3309); Region: DUF3309; pfam11752 398527018647 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 398527018648 catalytic core [active] 398527018649 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 398527018650 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 398527018651 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 398527018652 polyphosphate kinase; Provisional; Region: PRK05443 398527018653 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 398527018654 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 398527018655 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 398527018656 putative active site [active] 398527018657 catalytic site [active] 398527018658 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 398527018659 putative domain interface [polypeptide binding]; other site 398527018660 putative active site [active] 398527018661 catalytic site [active] 398527018662 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 398527018663 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 398527018664 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 398527018665 dimer interface [polypeptide binding]; other site 398527018666 phosphorylation site [posttranslational modification] 398527018667 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527018668 ATP binding site [chemical binding]; other site 398527018669 Mg2+ binding site [ion binding]; other site 398527018670 G-X-G motif; other site 398527018671 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 398527018672 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527018673 active site 398527018674 phosphorylation site [posttranslational modification] 398527018675 intermolecular recognition site; other site 398527018676 dimerization interface [polypeptide binding]; other site 398527018677 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 398527018678 DNA binding site [nucleotide binding] 398527018679 transcriptional regulator PhoU; Provisional; Region: PRK11115 398527018680 PhoU domain; Region: PhoU; pfam01895 398527018681 PhoU domain; Region: PhoU; pfam01895 398527018682 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 398527018683 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 398527018684 Walker A/P-loop; other site 398527018685 ATP binding site [chemical binding]; other site 398527018686 Q-loop/lid; other site 398527018687 ABC transporter signature motif; other site 398527018688 Walker B; other site 398527018689 D-loop; other site 398527018690 H-loop/switch region; other site 398527018691 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 398527018692 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527018693 dimer interface [polypeptide binding]; other site 398527018694 conserved gate region; other site 398527018695 putative PBP binding loops; other site 398527018696 ABC-ATPase subunit interface; other site 398527018697 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 398527018698 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527018699 dimer interface [polypeptide binding]; other site 398527018700 conserved gate region; other site 398527018701 putative PBP binding loops; other site 398527018702 ABC-ATPase subunit interface; other site 398527018703 PBP superfamily domain; Region: PBP_like_2; cl17296 398527018704 Transposase, Mutator family; Region: Transposase_mut; pfam00872 398527018705 MULE transposase domain; Region: MULE; pfam10551 398527018706 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 398527018707 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 398527018708 active site 398527018709 substrate binding site [chemical binding]; other site 398527018710 metal binding site [ion binding]; metal-binding site 398527018711 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 398527018712 dihydropteroate synthase; Region: DHPS; TIGR01496 398527018713 substrate binding pocket [chemical binding]; other site 398527018714 dimer interface [polypeptide binding]; other site 398527018715 inhibitor binding site; inhibition site 398527018716 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 398527018717 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527018718 Walker A motif; other site 398527018719 ATP binding site [chemical binding]; other site 398527018720 Walker B motif; other site 398527018721 arginine finger; other site 398527018722 Peptidase family M41; Region: Peptidase_M41; pfam01434 398527018723 FtsJ-like methyltransferase; Region: FtsJ; cl17430 398527018724 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 398527018725 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 398527018726 Domain of unknown function (DUF4149); Region: DUF4149; pfam13664 398527018727 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 398527018728 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 398527018729 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 398527018730 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 398527018731 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 398527018732 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 398527018733 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 398527018734 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 398527018735 ATP-grasp domain; Region: ATP-grasp_4; cl17255 398527018736 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 398527018737 IMP binding site; other site 398527018738 dimer interface [polypeptide binding]; other site 398527018739 interdomain contacts; other site 398527018740 partial ornithine binding site; other site 398527018741 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 398527018742 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 398527018743 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 398527018744 catalytic site [active] 398527018745 subunit interface [polypeptide binding]; other site 398527018746 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527018747 Major Facilitator Superfamily; Region: MFS_1; pfam07690 398527018748 putative substrate translocation pore; other site 398527018749 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 398527018750 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 398527018751 N-acetyl-D-glucosamine binding site [chemical binding]; other site 398527018752 catalytic residue [active] 398527018753 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 398527018754 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 398527018755 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 398527018756 Methyltransferase domain; Region: Methyltransf_11; pfam08241 398527018757 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 398527018758 RNA/DNA hybrid binding site [nucleotide binding]; other site 398527018759 active site 398527018760 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 398527018761 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 398527018762 active site 398527018763 catalytic site [active] 398527018764 substrate binding site [chemical binding]; other site 398527018765 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 398527018766 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 398527018767 Walker A/P-loop; other site 398527018768 ATP binding site [chemical binding]; other site 398527018769 Q-loop/lid; other site 398527018770 ABC transporter signature motif; other site 398527018771 Walker B; other site 398527018772 D-loop; other site 398527018773 H-loop/switch region; other site 398527018774 Predicted membrane protein (DUF2214); Region: DUF2214; pfam09980 398527018775 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 398527018776 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 398527018777 putative ADP-binding pocket [chemical binding]; other site 398527018778 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 398527018779 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 398527018780 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 398527018781 Walker A/P-loop; other site 398527018782 ATP binding site [chemical binding]; other site 398527018783 Q-loop/lid; other site 398527018784 ABC transporter signature motif; other site 398527018785 Walker B; other site 398527018786 D-loop; other site 398527018787 H-loop/switch region; other site 398527018788 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 398527018789 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 398527018790 active site 398527018791 homotetramer interface [polypeptide binding]; other site 398527018792 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 398527018793 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 398527018794 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 398527018795 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 398527018796 Cu(I) binding site [ion binding]; other site 398527018797 Protein of unknown function (DUF461); Region: DUF461; pfam04314 398527018798 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 398527018799 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 398527018800 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 398527018801 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 398527018802 GAF domain; Region: GAF; pfam01590 398527018803 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 398527018804 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 398527018805 metal binding site [ion binding]; metal-binding site 398527018806 active site 398527018807 I-site; other site 398527018808 TraB family; Region: TraB; pfam01963 398527018809 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 398527018810 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 398527018811 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 398527018812 GIY-YIG motif/motif A; other site 398527018813 active site 398527018814 catalytic site [active] 398527018815 putative DNA binding site [nucleotide binding]; other site 398527018816 metal binding site [ion binding]; metal-binding site 398527018817 UvrB/uvrC motif; Region: UVR; pfam02151 398527018818 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 398527018819 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 398527018820 Uncharacterized protein conserved in bacteria (DUF2331); Region: DUF2331; pfam10093 398527018821 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4394 398527018822 elongation factor P; Validated; Region: PRK00529 398527018823 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 398527018824 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 398527018825 RNA binding site [nucleotide binding]; other site 398527018826 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 398527018827 RNA binding site [nucleotide binding]; other site 398527018828 CsbD-like; Region: CsbD; pfam05532 398527018829 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 398527018830 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527018831 active site 398527018832 phosphorylation site [posttranslational modification] 398527018833 intermolecular recognition site; other site 398527018834 dimerization interface [polypeptide binding]; other site 398527018835 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527018836 Walker A motif; other site 398527018837 ATP binding site [chemical binding]; other site 398527018838 Walker B motif; other site 398527018839 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 398527018840 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 398527018841 beta-hexosaminidase; Provisional; Region: PRK05337 398527018842 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 398527018843 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 398527018844 active site 398527018845 hydrophilic channel; other site 398527018846 dimerization interface [polypeptide binding]; other site 398527018847 catalytic residues [active] 398527018848 active site lid [active] 398527018849 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 398527018850 Recombination protein O N terminal; Region: RecO_N; pfam11967 398527018851 Recombination protein O C terminal; Region: RecO_C; pfam02565 398527018852 GTPase Era; Reviewed; Region: era; PRK00089 398527018853 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 398527018854 G1 box; other site 398527018855 GTP/Mg2+ binding site [chemical binding]; other site 398527018856 Switch I region; other site 398527018857 G2 box; other site 398527018858 Switch II region; other site 398527018859 G3 box; other site 398527018860 G4 box; other site 398527018861 G5 box; other site 398527018862 KH domain; Region: KH_2; pfam07650 398527018863 ribonuclease III; Reviewed; Region: PRK12372 398527018864 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 398527018865 dimerization interface [polypeptide binding]; other site 398527018866 active site 398527018867 metal binding site [ion binding]; metal-binding site 398527018868 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 398527018869 signal peptidase I; Provisional; Region: PRK10861 398527018870 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 398527018871 Catalytic site [active] 398527018872 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 398527018873 GTP-binding protein LepA; Provisional; Region: PRK05433 398527018874 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 398527018875 G1 box; other site 398527018876 putative GEF interaction site [polypeptide binding]; other site 398527018877 GTP/Mg2+ binding site [chemical binding]; other site 398527018878 Switch I region; other site 398527018879 G2 box; other site 398527018880 G3 box; other site 398527018881 Switch II region; other site 398527018882 G4 box; other site 398527018883 G5 box; other site 398527018884 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 398527018885 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 398527018886 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 398527018887 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 398527018888 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 398527018889 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 398527018890 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 398527018891 protein binding site [polypeptide binding]; other site 398527018892 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 398527018893 protein binding site [polypeptide binding]; other site 398527018894 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 398527018895 anti-sigma E factor; Provisional; Region: rseB; PRK09455 398527018896 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 398527018897 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 398527018898 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 398527018899 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 398527018900 DNA binding residues [nucleotide binding] 398527018901 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 398527018902 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 398527018903 dimer interface [polypeptide binding]; other site 398527018904 active site 398527018905 acyl carrier protein; Provisional; Region: acpP; PRK00982 398527018906 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 398527018907 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 398527018908 NAD(P) binding site [chemical binding]; other site 398527018909 homotetramer interface [polypeptide binding]; other site 398527018910 homodimer interface [polypeptide binding]; other site 398527018911 active site 398527018912 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 398527018913 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 398527018914 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 398527018915 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 398527018916 dimer interface [polypeptide binding]; other site 398527018917 active site 398527018918 CoA binding pocket [chemical binding]; other site 398527018919 putative phosphate acyltransferase; Provisional; Region: PRK05331 398527018920 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 398527018921 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 398527018922 Maf-like protein; Region: Maf; pfam02545 398527018923 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 398527018924 active site 398527018925 dimer interface [polypeptide binding]; other site 398527018926 Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649 398527018927 putative SAM binding site [chemical binding]; other site 398527018928 homodimer interface [polypeptide binding]; other site 398527018929 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 398527018930 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 398527018931 tandem repeat interface [polypeptide binding]; other site 398527018932 oligomer interface [polypeptide binding]; other site 398527018933 active site residues [active] 398527018934 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 398527018935 iron-sulfur cluster [ion binding]; other site 398527018936 [2Fe-2S] cluster binding site [ion binding]; other site 398527018937 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 398527018938 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 398527018939 motif II; other site 398527018940 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 398527018941 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 398527018942 RNA binding surface [nucleotide binding]; other site 398527018943 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 398527018944 active site 398527018945 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 398527018946 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 398527018947 homodimer interface [polypeptide binding]; other site 398527018948 oligonucleotide binding site [chemical binding]; other site 398527018949 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 398527018950 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 398527018951 FeS/SAM binding site; other site 398527018952 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 398527018953 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 398527018954 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 398527018955 GTP binding site; other site 398527018956 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 398527018957 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 398527018958 dimer interface [polypeptide binding]; other site 398527018959 putative functional site; other site 398527018960 putative MPT binding site; other site 398527018961 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 398527018962 Coenzyme A binding pocket [chemical binding]; other site 398527018963 RmuC family; Region: RmuC; pfam02646 398527018964 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 398527018965 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 398527018966 dimerization interface [polypeptide binding]; other site 398527018967 ligand binding site [chemical binding]; other site 398527018968 NADP binding site [chemical binding]; other site 398527018969 catalytic site [active] 398527018970 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 398527018971 Uncharacterized conserved protein [Function unknown]; Region: COG1556 398527018972 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 398527018973 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 398527018974 active site 398527018975 Ferredoxin [Energy production and conversion]; Region: COG1146 398527018976 4Fe-4S binding domain; Region: Fer4; cl02805 398527018977 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 398527018978 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045 398527018979 CreA protein; Region: CreA; pfam05981 398527018980 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 398527018981 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 398527018982 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527018983 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527018984 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 398527018985 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 398527018986 Protein of unknown function (DUF4088); Region: DUF4088; pfam13317 398527018987 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 398527018988 Part of AAA domain; Region: AAA_19; pfam13245 398527018989 Family description; Region: UvrD_C_2; pfam13538 398527018990 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 398527018991 RNA binding surface [nucleotide binding]; other site 398527018992 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 398527018993 multidrug efflux protein; Reviewed; Region: PRK01766 398527018994 cation binding site [ion binding]; other site 398527018995 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 398527018996 Sodium Bile acid symporter family; Region: SBF; pfam01758 398527018997 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 398527018998 PLD-like domain; Region: PLDc_2; pfam13091 398527018999 putative active site [active] 398527019000 catalytic site [active] 398527019001 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 398527019002 PLD-like domain; Region: PLDc_2; pfam13091 398527019003 putative active site [active] 398527019004 catalytic site [active] 398527019005 fumarate hydratase; Reviewed; Region: fumC; PRK00485 398527019006 Class II fumarases; Region: Fumarase_classII; cd01362 398527019007 active site 398527019008 tetramer interface [polypeptide binding]; other site 398527019009 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 398527019010 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 398527019011 conserved cys residue [active] 398527019012 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 398527019013 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527019014 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527019015 Major Facilitator Superfamily; Region: MFS_1; pfam07690 398527019016 putative substrate translocation pore; other site 398527019017 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 398527019018 dimerization interface [polypeptide binding]; other site 398527019019 putative DNA binding site [nucleotide binding]; other site 398527019020 putative Zn2+ binding site [ion binding]; other site 398527019021 thymidylate synthase; Provisional; Region: thyA; PRK13821 398527019022 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 398527019023 dimerization interface [polypeptide binding]; other site 398527019024 active site 398527019025 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527019026 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 398527019027 Walker A motif; other site 398527019028 ATP binding site [chemical binding]; other site 398527019029 Walker B motif; other site 398527019030 arginine finger; other site 398527019031 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 398527019032 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423 398527019033 putative active site [active] 398527019034 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 398527019035 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 398527019036 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527019037 Walker A motif; other site 398527019038 ATP binding site [chemical binding]; other site 398527019039 Walker B motif; other site 398527019040 arginine finger; other site 398527019041 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 398527019042 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 398527019043 folate binding site [chemical binding]; other site 398527019044 NADP+ binding site [chemical binding]; other site 398527019045 peptidase PmbA; Provisional; Region: PRK11040 398527019046 hypothetical protein; Provisional; Region: PRK05255 398527019047 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 398527019048 MPT binding site; other site 398527019049 trimer interface [polypeptide binding]; other site 398527019050 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 398527019051 catalytic site [active] 398527019052 putative active site [active] 398527019053 putative substrate binding site [chemical binding]; other site 398527019054 dimer interface [polypeptide binding]; other site 398527019055 Peptidase family M48; Region: Peptidase_M48; pfam01435 398527019056 GTPase RsgA; Reviewed; Region: PRK00098 398527019057 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 398527019058 RNA binding site [nucleotide binding]; other site 398527019059 homodimer interface [polypeptide binding]; other site 398527019060 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 398527019061 GTPase/Zn-binding domain interface [polypeptide binding]; other site 398527019062 GTP/Mg2+ binding site [chemical binding]; other site 398527019063 G4 box; other site 398527019064 G5 box; other site 398527019065 G1 box; other site 398527019066 Switch I region; other site 398527019067 G2 box; other site 398527019068 G3 box; other site 398527019069 Switch II region; other site 398527019070 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 398527019071 CobD/CbiB family protein; Provisional; Region: PRK07630 398527019072 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 398527019073 putative active site [active] 398527019074 putative CoA binding site [chemical binding]; other site 398527019075 nudix motif; other site 398527019076 metal binding site [ion binding]; metal-binding site 398527019077 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 398527019078 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 398527019079 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 398527019080 RimM N-terminal domain; Region: RimM; pfam01782 398527019081 PRC-barrel domain; Region: PRC; pfam05239 398527019082 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 398527019083 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 398527019084 YWTD domain; Region: YWTD; cl17223 398527019085 Domain of unknown function (DUF373); Region: DUF373; cl12079 398527019086 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 398527019087 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 398527019088 FeS/SAM binding site; other site 398527019089 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 398527019090 AsnC family; Region: AsnC_trans_reg; pfam01037 398527019091 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 398527019092 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 398527019093 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 398527019094 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 398527019095 active site 398527019096 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 398527019097 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 398527019098 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 398527019099 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 398527019100 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 398527019101 Ligand binding site [chemical binding]; other site 398527019102 Electron transfer flavoprotein domain; Region: ETF; pfam01012 398527019103 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 398527019104 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 398527019105 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527019106 dimer interface [polypeptide binding]; other site 398527019107 conserved gate region; other site 398527019108 ABC-ATPase subunit interface; other site 398527019109 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 398527019110 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 398527019111 Walker A/P-loop; other site 398527019112 ATP binding site [chemical binding]; other site 398527019113 Q-loop/lid; other site 398527019114 ABC transporter signature motif; other site 398527019115 Walker B; other site 398527019116 D-loop; other site 398527019117 H-loop/switch region; other site 398527019118 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 398527019119 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 398527019120 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 398527019121 enoyl-CoA hydratase; Validated; Region: PRK08139 398527019122 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 398527019123 substrate binding site [chemical binding]; other site 398527019124 oxyanion hole (OAH) forming residues; other site 398527019125 trimer interface [polypeptide binding]; other site 398527019126 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 398527019127 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 398527019128 putative active site [active] 398527019129 Zn binding site [ion binding]; other site 398527019130 Transglycosylase SLT domain; Region: SLT_2; pfam13406 398527019131 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 398527019132 N-acetyl-D-glucosamine binding site [chemical binding]; other site 398527019133 cysteine synthase B; Region: cysM; TIGR01138 398527019134 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 398527019135 dimer interface [polypeptide binding]; other site 398527019136 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527019137 catalytic residue [active] 398527019138 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 398527019139 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 398527019140 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 398527019141 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 398527019142 NADP binding site [chemical binding]; other site 398527019143 homopentamer interface [polypeptide binding]; other site 398527019144 substrate binding site [chemical binding]; other site 398527019145 active site 398527019146 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 398527019147 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 398527019148 putative ribose interaction site [chemical binding]; other site 398527019149 putative ADP binding site [chemical binding]; other site 398527019150 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 398527019151 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 398527019152 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 398527019153 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 398527019154 tetratricopeptide repeat protein; Provisional; Region: PRK11788 398527019155 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 398527019156 binding surface 398527019157 TPR motif; other site 398527019158 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 398527019159 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 398527019160 IHF dimer interface [polypeptide binding]; other site 398527019161 IHF - DNA interface [nucleotide binding]; other site 398527019162 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 398527019163 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 398527019164 RNA binding site [nucleotide binding]; other site 398527019165 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 398527019166 RNA binding site [nucleotide binding]; other site 398527019167 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 398527019168 RNA binding site [nucleotide binding]; other site 398527019169 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 398527019170 RNA binding site [nucleotide binding]; other site 398527019171 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 398527019172 RNA binding site [nucleotide binding]; other site 398527019173 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 398527019174 RNA binding site [nucleotide binding]; other site 398527019175 cytidylate kinase; Provisional; Region: cmk; PRK00023 398527019176 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 398527019177 CMP-binding site; other site 398527019178 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 398527019179 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 398527019180 hinge; other site 398527019181 active site 398527019182 prephenate dehydrogenase; Validated; Region: PRK08507 398527019183 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 398527019184 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 398527019185 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527019186 homodimer interface [polypeptide binding]; other site 398527019187 catalytic residue [active] 398527019188 Chorismate mutase type II; Region: CM_2; smart00830 398527019189 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 398527019190 Prephenate dehydratase; Region: PDT; pfam00800 398527019191 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 398527019192 putative L-Phe binding site [chemical binding]; other site 398527019193 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 398527019194 homodimer interface [polypeptide binding]; other site 398527019195 substrate-cofactor binding pocket; other site 398527019196 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527019197 catalytic residue [active] 398527019198 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 398527019199 DNA gyrase subunit A; Validated; Region: PRK05560 398527019200 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 398527019201 CAP-like domain; other site 398527019202 active site 398527019203 primary dimer interface [polypeptide binding]; other site 398527019204 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 398527019205 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 398527019206 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 398527019207 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 398527019208 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 398527019209 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 398527019210 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 398527019211 ligand binding site [chemical binding]; other site 398527019212 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 398527019213 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 398527019214 S-adenosylmethionine binding site [chemical binding]; other site 398527019215 phosphoglycolate phosphatase; Provisional; Region: PRK13222 398527019216 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 398527019217 motif II; other site 398527019218 Domain of unknown function (DUF4285); Region: DUF4285; pfam14113 398527019219 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 398527019220 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 398527019221 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 398527019222 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 398527019223 PBP superfamily domain; Region: PBP_like; pfam12727 398527019224 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 398527019225 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily, NAD-dependent formate dehydrogenase (FDH) gamma subunit; composed of proteins similar to the gamma subunit of NAD-linked FDH of Ralstonia eutropha, a...; Region: TRX_Fd_NuoE_FDH_gamma; cd03081 398527019226 putative dimer interface [polypeptide binding]; other site 398527019227 [2Fe-2S] cluster binding site [ion binding]; other site 398527019228 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NAD-dependent formate dehydrogenase (FDH) beta subunit; composed of proteins similar to the beta subunit of NAD-linked FDH of Ralstonia eutropha, a soluble enzyme that catalyzes the irreversible oxidation of...; Region: TRX_Fd_FDH_beta; cd03063 398527019229 putative dimer interface [polypeptide binding]; other site 398527019230 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 398527019231 SLBB domain; Region: SLBB; pfam10531 398527019232 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 398527019233 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 398527019234 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 398527019235 catalytic loop [active] 398527019236 iron binding site [ion binding]; other site 398527019237 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929 398527019238 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 398527019239 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 398527019240 [4Fe-4S] binding site [ion binding]; other site 398527019241 molybdopterin cofactor binding site; other site 398527019242 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 398527019243 molybdopterin cofactor binding site; other site 398527019244 NADH-dependant formate dehydrogenase delta subunit FdsD; Region: FdsD; pfam11390 398527019245 hypothetical protein; Provisional; Region: PRK06184 398527019246 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 398527019247 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 398527019248 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 398527019249 dimerization interface [polypeptide binding]; other site 398527019250 putative DNA binding site [nucleotide binding]; other site 398527019251 putative Zn2+ binding site [ion binding]; other site 398527019252 Tetratricopeptide repeat; Region: TPR_16; pfam13432 398527019253 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 398527019254 TPR motif; other site 398527019255 binding surface 398527019256 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 398527019257 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 398527019258 binding surface 398527019259 TPR motif; other site 398527019260 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 398527019261 binding surface 398527019262 TPR motif; other site 398527019263 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 398527019264 binding surface 398527019265 TPR motif; other site 398527019266 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 398527019267 citrate-proton symporter; Provisional; Region: PRK15075 398527019268 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527019269 putative substrate translocation pore; other site 398527019270 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 398527019271 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 398527019272 Coenzyme A binding pocket [chemical binding]; other site 398527019273 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 398527019274 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 398527019275 Peptidase C26; Region: Peptidase_C26; pfam07722 398527019276 catalytic triad [active] 398527019277 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 398527019278 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 398527019279 Protein of unknown function (DUF2848); Region: DUF2848; pfam11010 398527019280 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527019281 D-galactonate transporter; Region: 2A0114; TIGR00893 398527019282 putative substrate translocation pore; other site 398527019283 Transcriptional regulators [Transcription]; Region: FadR; COG2186 398527019284 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527019285 DNA-binding site [nucleotide binding]; DNA binding site 398527019286 FCD domain; Region: FCD; pfam07729 398527019287 amidase; Provisional; Region: PRK07056 398527019288 Amidase; Region: Amidase; cl11426 398527019289 disulfide bond formation protein B; Provisional; Region: PRK02110 398527019290 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 398527019291 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 398527019292 catalytic loop [active] 398527019293 iron binding site [ion binding]; other site 398527019294 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 398527019295 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 398527019296 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 398527019297 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 398527019298 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 398527019299 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 398527019300 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 398527019301 XdhC Rossmann domain; Region: XdhC_C; pfam13478 398527019302 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 398527019303 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 398527019304 active site 398527019305 purine riboside binding site [chemical binding]; other site 398527019306 guanine deaminase; Provisional; Region: PRK09228 398527019307 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 398527019308 active site 398527019309 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 398527019310 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 398527019311 S-adenosylmethionine binding site [chemical binding]; other site 398527019312 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 398527019313 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 398527019314 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 398527019315 dimer interface [polypeptide binding]; other site 398527019316 active site 398527019317 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 398527019318 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 398527019319 dimer interface [polypeptide binding]; other site 398527019320 active site 398527019321 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 398527019322 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 398527019323 NAD(P) binding site [chemical binding]; other site 398527019324 homotetramer interface [polypeptide binding]; other site 398527019325 homodimer interface [polypeptide binding]; other site 398527019326 active site 398527019327 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 398527019328 putative active site 1 [active] 398527019329 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 398527019330 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 398527019331 dimer interface [polypeptide binding]; other site 398527019332 active site 398527019333 Predicted exporter [General function prediction only]; Region: COG4258 398527019334 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 398527019335 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 398527019336 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 398527019337 active site 398527019338 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 398527019339 active sites [active] 398527019340 tetramer interface [polypeptide binding]; other site 398527019341 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 398527019342 Ligand binding site; other site 398527019343 Putative Catalytic site; other site 398527019344 DXD motif; other site 398527019345 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 398527019346 putative acyl-acceptor binding pocket; other site 398527019347 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 398527019348 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 398527019349 AMP binding site [chemical binding]; other site 398527019350 active site 398527019351 acyl-activating enzyme (AAE) consensus motif; other site 398527019352 CoA binding site [chemical binding]; other site 398527019353 FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493 398527019354 active site 2 [active] 398527019355 dimer interface [polypeptide binding]; other site 398527019356 active site 1 [active] 398527019357 Predicted membrane protein [Function unknown]; Region: COG4648 398527019358 acyl carrier protein; Provisional; Region: PRK05350 398527019359 Phosphopantetheine attachment site; Region: PP-binding; cl09936 398527019360 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 398527019361 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 398527019362 putative acyl-acceptor binding pocket; other site 398527019363 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 398527019364 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 398527019365 aminopeptidase N; Provisional; Region: pepN; PRK14015 398527019366 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 398527019367 active site 398527019368 Zn binding site [ion binding]; other site 398527019369 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 398527019370 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 398527019371 addiction module antidote protein, HigA family; Region: antidote_HigA; TIGR02607 398527019372 non-specific DNA binding site [nucleotide binding]; other site 398527019373 salt bridge; other site 398527019374 sequence-specific DNA binding site [nucleotide binding]; other site 398527019375 fructose-1,6-bisphosphatase family protein; Region: PLN02628 398527019376 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 398527019377 AMP binding site [chemical binding]; other site 398527019378 metal binding site [ion binding]; metal-binding site 398527019379 active site 398527019380 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 398527019381 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 398527019382 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 398527019383 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 398527019384 Walker A/P-loop; other site 398527019385 ATP binding site [chemical binding]; other site 398527019386 Q-loop/lid; other site 398527019387 ABC transporter signature motif; other site 398527019388 Walker B; other site 398527019389 D-loop; other site 398527019390 H-loop/switch region; other site 398527019391 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 398527019392 Transposase; Region: HTH_Tnp_1; pfam01527 398527019393 putative transposase OrfB; Reviewed; Region: PHA02517 398527019394 HTH-like domain; Region: HTH_21; pfam13276 398527019395 Integrase core domain; Region: rve; pfam00665 398527019396 Integrase core domain; Region: rve_3; pfam13683 398527019397 chorismate mutase; Provisional; Region: PRK09269 398527019398 Chorismate mutase type II; Region: CM_2; cl00693 398527019399 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 398527019400 active site 398527019401 catalytic site [active] 398527019402 substrate binding site [chemical binding]; other site 398527019403 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 398527019404 GIY-YIG motif/motif A; other site 398527019405 active site 398527019406 catalytic site [active] 398527019407 putative DNA binding site [nucleotide binding]; other site 398527019408 metal binding site [ion binding]; metal-binding site 398527019409 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 398527019410 DNA-binding site [nucleotide binding]; DNA binding site 398527019411 RNA-binding motif; other site 398527019412 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 398527019413 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 398527019414 trimer interface [polypeptide binding]; other site 398527019415 eyelet of channel; other site 398527019416 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 398527019417 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 398527019418 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 398527019419 Protein of unknown function (DUF2591); Region: DUF2591; cl11584 398527019420 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 398527019421 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 398527019422 Zn2+ binding site [ion binding]; other site 398527019423 Mg2+ binding site [ion binding]; other site 398527019424 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 398527019425 synthetase active site [active] 398527019426 NTP binding site [chemical binding]; other site 398527019427 metal binding site [ion binding]; metal-binding site 398527019428 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 398527019429 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 398527019430 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 398527019431 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 398527019432 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 398527019433 catalytic site [active] 398527019434 G-X2-G-X-G-K; other site 398527019435 hypothetical protein; Provisional; Region: PRK11820 398527019436 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 398527019437 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 398527019438 ribonuclease PH; Reviewed; Region: rph; PRK00173 398527019439 Ribonuclease PH; Region: RNase_PH_bact; cd11362 398527019440 hexamer interface [polypeptide binding]; other site 398527019441 active site 398527019442 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 398527019443 active site 398527019444 dimerization interface [polypeptide binding]; other site 398527019445 coproporphyrinogen III oxidase; Provisional; Region: PRK08898 398527019446 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 398527019447 FeS/SAM binding site; other site 398527019448 HemN C-terminal domain; Region: HemN_C; pfam06969 398527019449 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 398527019450 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 398527019451 homotrimer interaction site [polypeptide binding]; other site 398527019452 putative active site [active] 398527019453 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527019454 putative substrate translocation pore; other site 398527019455 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 398527019456 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 398527019457 inhibitor-cofactor binding pocket; inhibition site 398527019458 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527019459 catalytic residue [active] 398527019460 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 398527019461 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 398527019462 catalytic motif [active] 398527019463 Zn binding site [ion binding]; other site 398527019464 RibD C-terminal domain; Region: RibD_C; cl17279 398527019465 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 398527019466 Lumazine binding domain; Region: Lum_binding; pfam00677 398527019467 Lumazine binding domain; Region: Lum_binding; pfam00677 398527019468 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 398527019469 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 398527019470 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 398527019471 dimerization interface [polypeptide binding]; other site 398527019472 active site 398527019473 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 398527019474 homopentamer interface [polypeptide binding]; other site 398527019475 active site 398527019476 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 398527019477 putative RNA binding site [nucleotide binding]; other site 398527019478 aminotransferase; Validated; Region: PRK07337 398527019479 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 398527019480 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527019481 homodimer interface [polypeptide binding]; other site 398527019482 catalytic residue [active] 398527019483 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 398527019484 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 398527019485 N-acetyl-D-glucosamine binding site [chemical binding]; other site 398527019486 catalytic residue [active] 398527019487 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 398527019488 LysE type translocator; Region: LysE; cl00565 398527019489 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 398527019490 tetramer interface [polypeptide binding]; other site 398527019491 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 398527019492 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527019493 catalytic residue [active] 398527019494 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 398527019495 Uncharacterized conserved protein [Function unknown]; Region: COG5495 398527019496 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 398527019497 EthD domain; Region: EthD; cl17553 398527019498 YGGT family; Region: YGGT; pfam02325 398527019499 YGGT family; Region: YGGT; pfam02325 398527019500 AAA domain; Region: AAA_31; pfam13614 398527019501 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 398527019502 P-loop; other site 398527019503 Magnesium ion binding site [ion binding]; other site 398527019504 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 398527019505 Magnesium ion binding site [ion binding]; other site 398527019506 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 398527019507 S-adenosylmethionine binding site [chemical binding]; other site 398527019508 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 398527019509 Protein of unknown function (DUF1439); Region: DUF1439; cl06345 398527019510 Flagellin N-methylase; Region: FliB; pfam03692 398527019511 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 398527019512 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 398527019513 FeS/SAM binding site; other site 398527019514 HemN C-terminal domain; Region: HemN_C; pfam06969 398527019515 aromatic amino acid transporter; Provisional; Region: PRK10238 398527019516 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 398527019517 pyruvate dehydrogenase; Provisional; Region: PRK09124 398527019518 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 398527019519 PYR/PP interface [polypeptide binding]; other site 398527019520 tetramer interface [polypeptide binding]; other site 398527019521 dimer interface [polypeptide binding]; other site 398527019522 TPP binding site [chemical binding]; other site 398527019523 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 398527019524 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 398527019525 TPP-binding site [chemical binding]; other site 398527019526 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 398527019527 SxDxEG motif; other site 398527019528 active site 398527019529 metal binding site [ion binding]; metal-binding site 398527019530 homopentamer interface [polypeptide binding]; other site 398527019531 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 398527019532 homodimer interface [polypeptide binding]; other site 398527019533 homotetramer interface [polypeptide binding]; other site 398527019534 active site pocket [active] 398527019535 cleavage site 398527019536 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 398527019537 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 398527019538 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527019539 dimer interface [polypeptide binding]; other site 398527019540 conserved gate region; other site 398527019541 putative PBP binding loops; other site 398527019542 ABC-ATPase subunit interface; other site 398527019543 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 398527019544 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527019545 dimer interface [polypeptide binding]; other site 398527019546 conserved gate region; other site 398527019547 putative PBP binding loops; other site 398527019548 ABC-ATPase subunit interface; other site 398527019549 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 398527019550 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 398527019551 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 398527019552 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 398527019553 Walker A/P-loop; other site 398527019554 ATP binding site [chemical binding]; other site 398527019555 Q-loop/lid; other site 398527019556 ABC transporter signature motif; other site 398527019557 Walker B; other site 398527019558 D-loop; other site 398527019559 H-loop/switch region; other site 398527019560 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 398527019561 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 398527019562 Walker A/P-loop; other site 398527019563 ATP binding site [chemical binding]; other site 398527019564 Q-loop/lid; other site 398527019565 ABC transporter signature motif; other site 398527019566 Walker B; other site 398527019567 D-loop; other site 398527019568 H-loop/switch region; other site 398527019569 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 398527019570 Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked...; Region: Ntn_Asparaginase_2_like; cl00635 398527019571 active site 398527019572 dimer interface [polypeptide binding]; other site 398527019573 catalytic nucleophile [active] 398527019574 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 398527019575 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 398527019576 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 398527019577 putative active site [active] 398527019578 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527019579 putative substrate translocation pore; other site 398527019580 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 398527019581 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 398527019582 active site 398527019583 uracil binding [chemical binding]; other site 398527019584 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 398527019585 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 398527019586 putative NAD(P) binding site [chemical binding]; other site 398527019587 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 398527019588 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 398527019589 catalytic loop [active] 398527019590 iron binding site [ion binding]; other site 398527019591 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 398527019592 FAD binding pocket [chemical binding]; other site 398527019593 FAD binding motif [chemical binding]; other site 398527019594 phosphate binding motif [ion binding]; other site 398527019595 beta-alpha-beta structure motif; other site 398527019596 NAD binding pocket [chemical binding]; other site 398527019597 acetylornithine transaminase protein; Provisional; Region: argD; PRK03715 398527019598 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 398527019599 inhibitor-cofactor binding pocket; inhibition site 398527019600 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527019601 catalytic residue [active] 398527019602 putative acetyltransferase; Provisional; Region: PRK03624 398527019603 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 398527019604 Coenzyme A binding pocket [chemical binding]; other site 398527019605 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 398527019606 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 398527019607 Walker A/P-loop; other site 398527019608 ATP binding site [chemical binding]; other site 398527019609 Q-loop/lid; other site 398527019610 ABC transporter signature motif; other site 398527019611 Walker B; other site 398527019612 D-loop; other site 398527019613 H-loop/switch region; other site 398527019614 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 398527019615 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 398527019616 Walker A/P-loop; other site 398527019617 ATP binding site [chemical binding]; other site 398527019618 Q-loop/lid; other site 398527019619 ABC transporter signature motif; other site 398527019620 Walker B; other site 398527019621 D-loop; other site 398527019622 H-loop/switch region; other site 398527019623 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 398527019624 TM-ABC transporter signature motif; other site 398527019625 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 398527019626 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 398527019627 TM-ABC transporter signature motif; other site 398527019628 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 398527019629 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 398527019630 dimerization interface [polypeptide binding]; other site 398527019631 ligand binding site [chemical binding]; other site 398527019632 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 398527019633 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 398527019634 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 398527019635 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 398527019636 hypothetical protein; Reviewed; Region: PRK00024 398527019637 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 398527019638 MPN+ (JAMM) motif; other site 398527019639 Zinc-binding site [ion binding]; other site 398527019640 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 398527019641 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 398527019642 L-aspartate oxidase; Provisional; Region: PRK09077 398527019643 L-aspartate oxidase; Provisional; Region: PRK06175 398527019644 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 398527019645 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06978 398527019646 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 398527019647 dimerization interface [polypeptide binding]; other site 398527019648 active site 398527019649 quinolinate synthetase; Provisional; Region: PRK09375 398527019650 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 398527019651 Fatty acid desaturase; Region: FA_desaturase; pfam00487 398527019652 Di-iron ligands [ion binding]; other site 398527019653 Transposase; Region: DDE_Tnp_ISL3; pfam01610 398527019654 Mechanosensitive ion channel; Region: MS_channel; pfam00924 398527019655 16S rRNA methyltransferase B; Provisional; Region: PRK14901 398527019656 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 398527019657 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 398527019658 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 398527019659 active site 398527019660 substrate binding site [chemical binding]; other site 398527019661 cosubstrate binding site; other site 398527019662 catalytic site [active] 398527019663 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 398527019664 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 398527019665 active site 398527019666 Riboflavin kinase; Region: Flavokinase; smart00904 398527019667 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 398527019668 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 398527019669 active site 398527019670 HIGH motif; other site 398527019671 nucleotide binding site [chemical binding]; other site 398527019672 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 398527019673 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 398527019674 active site 398527019675 KMSKS motif; other site 398527019676 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 398527019677 tRNA binding surface [nucleotide binding]; other site 398527019678 anticodon binding site; other site 398527019679 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 398527019680 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 398527019681 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 398527019682 Flavoprotein; Region: Flavoprotein; pfam02441 398527019683 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 398527019684 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 398527019685 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 398527019686 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 398527019687 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 398527019688 trimer interface [polypeptide binding]; other site 398527019689 active site 398527019690 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 398527019691 Clp amino terminal domain; Region: Clp_N; pfam02861 398527019692 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527019693 Walker A motif; other site 398527019694 ATP binding site [chemical binding]; other site 398527019695 Walker B motif; other site 398527019696 arginine finger; other site 398527019697 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527019698 Walker A motif; other site 398527019699 ATP binding site [chemical binding]; other site 398527019700 Walker B motif; other site 398527019701 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 398527019702 Uncharacterized conserved protein [Function unknown]; Region: COG2127 398527019703 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 398527019704 DNA-binding site [nucleotide binding]; DNA binding site 398527019705 RNA-binding motif; other site 398527019706 isocitrate dehydrogenase; Validated; Region: PRK07362 398527019707 isocitrate dehydrogenase; Reviewed; Region: PRK07006 398527019708 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 398527019709 pseudouridine synthase; Region: TIGR00093 398527019710 active site 398527019711 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 398527019712 elongation factor G; Reviewed; Region: PRK00007 398527019713 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 398527019714 G1 box; other site 398527019715 putative GEF interaction site [polypeptide binding]; other site 398527019716 GTP/Mg2+ binding site [chemical binding]; other site 398527019717 Switch I region; other site 398527019718 G2 box; other site 398527019719 G3 box; other site 398527019720 Switch II region; other site 398527019721 G4 box; other site 398527019722 G5 box; other site 398527019723 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 398527019724 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 398527019725 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 398527019726 Cupin domain; Region: Cupin_2; cl17218 398527019727 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 398527019728 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 398527019729 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 398527019730 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 398527019731 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527019732 dimer interface [polypeptide binding]; other site 398527019733 conserved gate region; other site 398527019734 putative PBP binding loops; other site 398527019735 ABC-ATPase subunit interface; other site 398527019736 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 398527019737 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527019738 putative PBP binding loops; other site 398527019739 dimer interface [polypeptide binding]; other site 398527019740 ABC-ATPase subunit interface; other site 398527019741 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 398527019742 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 398527019743 Walker A/P-loop; other site 398527019744 ATP binding site [chemical binding]; other site 398527019745 Q-loop/lid; other site 398527019746 ABC transporter signature motif; other site 398527019747 Walker B; other site 398527019748 D-loop; other site 398527019749 H-loop/switch region; other site 398527019750 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 398527019751 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 398527019752 Walker A/P-loop; other site 398527019753 ATP binding site [chemical binding]; other site 398527019754 Q-loop/lid; other site 398527019755 ABC transporter signature motif; other site 398527019756 Walker B; other site 398527019757 D-loop; other site 398527019758 H-loop/switch region; other site 398527019759 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 398527019760 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 398527019761 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 398527019762 active site 398527019763 catalytic tetrad [active] 398527019764 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 398527019765 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527019766 DNA-binding site [nucleotide binding]; DNA binding site 398527019767 UTRA domain; Region: UTRA; pfam07702 398527019768 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 398527019769 CoA-transferase family III; Region: CoA_transf_3; pfam02515 398527019770 Helix-turn-helix domain; Region: HTH_17; pfam12728 398527019771 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102 398527019772 active site 398527019773 coenzyme A binding site [chemical binding]; other site 398527019774 citrylCoA binding site [chemical binding]; other site 398527019775 dimer interface [polypeptide binding]; other site 398527019776 Citrate synthase; Region: Citrate_synt; pfam00285 398527019777 oxalacetate/citrate binding site [chemical binding]; other site 398527019778 catalytic triad [active] 398527019779 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 398527019780 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 398527019781 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527019782 DNA-binding site [nucleotide binding]; DNA binding site 398527019783 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 398527019784 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527019785 homodimer interface [polypeptide binding]; other site 398527019786 catalytic residue [active] 398527019787 putative transporter; Provisional; Region: PRK10504 398527019788 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527019789 putative substrate translocation pore; other site 398527019790 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 398527019791 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 398527019792 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 398527019793 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 398527019794 DNA binding residues [nucleotide binding] 398527019795 Clp protease; Region: CLP_protease; pfam00574 398527019796 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 398527019797 oligomer interface [polypeptide binding]; other site 398527019798 active site residues [active] 398527019799 LabA_like proteins; Region: LabA_like; cd06167 398527019800 putative metal binding site [ion binding]; other site 398527019801 Uncharacterized conserved protein [Function unknown]; Region: COG1432 398527019802 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 398527019803 Glycine-zipper containing OmpA-like membrane domain; Region: Gly-zipper_OmpA; pfam13436 398527019804 superoxide dismutase; Provisional; Region: PRK10543 398527019805 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 398527019806 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 398527019807 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 398527019808 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 398527019809 generic binding surface II; other site 398527019810 generic binding surface I; other site 398527019811 tetraacyldisaccharide 4'-kinase; Provisional; Region: PRK01906 398527019812 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 398527019813 Uncharacterized conserved protein [Function unknown]; Region: COG2835 398527019814 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 398527019815 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 398527019816 Ligand binding site; other site 398527019817 oligomer interface; other site 398527019818 adenylate kinase; Reviewed; Region: adk; PRK00279 398527019819 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 398527019820 AMP-binding site [chemical binding]; other site 398527019821 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 398527019822 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 398527019823 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 398527019824 NAD(P) binding site [chemical binding]; other site 398527019825 active site 398527019826 Uncharacterized conserved protein [Function unknown]; Region: COG2912 398527019827 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 398527019828 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 398527019829 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 398527019830 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 398527019831 Protein of unknown function (DUF3579); Region: DUF3579; pfam12112 398527019832 ornithine carbamoyltransferase; Provisional; Region: PRK00779 398527019833 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 398527019834 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 398527019835 argininosuccinate synthase; Provisional; Region: PRK13820 398527019836 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 398527019837 ANP binding site [chemical binding]; other site 398527019838 Substrate Binding Site II [chemical binding]; other site 398527019839 Substrate Binding Site I [chemical binding]; other site 398527019840 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 398527019841 FAD binding domain; Region: FAD_binding_4; pfam01565 398527019842 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 398527019843 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 398527019844 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 398527019845 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 398527019846 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 398527019847 putative deacylase active site [active] 398527019848 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 398527019849 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 398527019850 acyl-activating enzyme (AAE) consensus motif; other site 398527019851 AMP binding site [chemical binding]; other site 398527019852 active site 398527019853 CoA binding site [chemical binding]; other site 398527019854 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 398527019855 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 398527019856 active site 398527019857 Int/Topo IB signature motif; other site 398527019858 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 398527019859 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 398527019860 DNA binding site [nucleotide binding] 398527019861 active site 398527019862 epoxyqueuosine reductase; Region: TIGR00276 398527019863 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 398527019864 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 398527019865 AMIN domain; Region: AMIN; pfam11741 398527019866 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 398527019867 active site 398527019868 metal binding site [ion binding]; metal-binding site 398527019869 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 398527019870 EamA-like transporter family; Region: EamA; pfam00892 398527019871 Pirin-related protein [General function prediction only]; Region: COG1741 398527019872 Pirin; Region: Pirin; pfam02678 398527019873 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 398527019874 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 398527019875 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 398527019876 catalytic residues [active] 398527019877 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 398527019878 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 398527019879 putative ATP binding site [chemical binding]; other site 398527019880 putative substrate interface [chemical binding]; other site 398527019881 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 398527019882 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 398527019883 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 398527019884 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 398527019885 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 398527019886 S-adenosylmethionine binding site [chemical binding]; other site 398527019887 Protein of unknown function DUF72; Region: DUF72; pfam01904 398527019888 methionine sulfoxide reductase A; Provisional; Region: PRK14054 398527019889 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 398527019890 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 398527019891 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 398527019892 putative DNA binding site [nucleotide binding]; other site 398527019893 putative Zn2+ binding site [ion binding]; other site 398527019894 AsnC family; Region: AsnC_trans_reg; pfam01037 398527019895 arylformamidase; Region: trp_arylform; TIGR03035 398527019896 Kynureninase [Amino acid transport and metabolism]; Region: COG3844 398527019897 kynureninase; Region: kynureninase; TIGR01814 398527019898 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 398527019899 catalytic residue [active] 398527019900 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 398527019901 short chain dehydrogenase; Provisional; Region: PRK07060 398527019902 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 398527019903 NAD(P) binding site [chemical binding]; other site 398527019904 active site 398527019905 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 398527019906 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 398527019907 N- and C-terminal domain interface [polypeptide binding]; other site 398527019908 putative active site [active] 398527019909 MgATP binding site [chemical binding]; other site 398527019910 catalytic site [active] 398527019911 metal binding site [ion binding]; metal-binding site 398527019912 putative xylulose binding site [chemical binding]; other site 398527019913 putative homodimer interface [polypeptide binding]; other site 398527019914 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 398527019915 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH2; cd08256 398527019916 putative NAD(P) binding site [chemical binding]; other site 398527019917 catalytic Zn binding site [ion binding]; other site 398527019918 structural Zn binding site [ion binding]; other site 398527019919 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 398527019920 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 398527019921 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 398527019922 TM-ABC transporter signature motif; other site 398527019923 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 398527019924 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 398527019925 Walker A/P-loop; other site 398527019926 ATP binding site [chemical binding]; other site 398527019927 Q-loop/lid; other site 398527019928 ABC transporter signature motif; other site 398527019929 Walker B; other site 398527019930 D-loop; other site 398527019931 H-loop/switch region; other site 398527019932 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 398527019933 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 398527019934 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 398527019935 putative ligand binding site [chemical binding]; other site 398527019936 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 398527019937 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 398527019938 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527019939 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 398527019940 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 398527019941 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 398527019942 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 398527019943 N- and C-terminal domain interface [polypeptide binding]; other site 398527019944 D-xylulose kinase; Region: XylB; TIGR01312 398527019945 active site 398527019946 MgATP binding site [chemical binding]; other site 398527019947 catalytic site [active] 398527019948 metal binding site [ion binding]; metal-binding site 398527019949 xylulose binding site [chemical binding]; other site 398527019950 homodimer interface [polypeptide binding]; other site 398527019951 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 398527019952 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 398527019953 Protein of unknown function (DUF1330); Region: DUF1330; pfam07045 398527019954 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 398527019955 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 398527019956 Walker A/P-loop; other site 398527019957 ATP binding site [chemical binding]; other site 398527019958 Q-loop/lid; other site 398527019959 ABC transporter signature motif; other site 398527019960 Walker B; other site 398527019961 D-loop; other site 398527019962 H-loop/switch region; other site 398527019963 TOBE domain; Region: TOBE_2; pfam08402 398527019964 TOBE domain; Region: TOBE_2; pfam08402 398527019965 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 398527019966 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 398527019967 active site 398527019968 motif I; other site 398527019969 motif II; other site 398527019970 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 398527019971 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527019972 dimer interface [polypeptide binding]; other site 398527019973 conserved gate region; other site 398527019974 putative PBP binding loops; other site 398527019975 ABC-ATPase subunit interface; other site 398527019976 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 398527019977 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527019978 dimer interface [polypeptide binding]; other site 398527019979 conserved gate region; other site 398527019980 putative PBP binding loops; other site 398527019981 ABC-ATPase subunit interface; other site 398527019982 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 398527019983 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 398527019984 sorbitol dehydrogenase; Provisional; Region: PRK07067 398527019985 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 398527019986 NAD(P) binding site [chemical binding]; other site 398527019987 active site 398527019988 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 398527019989 metal binding site 2 [ion binding]; metal-binding site 398527019990 putative DNA binding helix; other site 398527019991 metal binding site 1 [ion binding]; metal-binding site 398527019992 dimer interface [polypeptide binding]; other site 398527019993 structural Zn2+ binding site [ion binding]; other site 398527019994 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 398527019995 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 398527019996 metal binding site [ion binding]; metal-binding site 398527019997 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 398527019998 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 398527019999 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 398527020000 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 398527020001 ABC-ATPase subunit interface; other site 398527020002 dimer interface [polypeptide binding]; other site 398527020003 putative PBP binding regions; other site 398527020004 S-formylglutathione hydrolase; Region: PLN02442 398527020005 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 398527020006 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 398527020007 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 398527020008 substrate binding site [chemical binding]; other site 398527020009 catalytic Zn binding site [ion binding]; other site 398527020010 NAD binding site [chemical binding]; other site 398527020011 structural Zn binding site [ion binding]; other site 398527020012 dimer interface [polypeptide binding]; other site 398527020013 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 398527020014 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 398527020015 nucleotide binding site [chemical binding]; other site 398527020016 xanthine permease; Region: pbuX; TIGR03173 398527020017 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 398527020018 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 398527020019 Protein export membrane protein; Region: SecD_SecF; cl14618 398527020020 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 398527020021 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 398527020022 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 398527020023 HlyD family secretion protein; Region: HlyD_3; pfam13437 398527020024 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 398527020025 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 398527020026 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 398527020027 Isochorismatase family; Region: Isochorismatase; pfam00857 398527020028 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 398527020029 catalytic triad [active] 398527020030 conserved cis-peptide bond; other site 398527020031 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 398527020032 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 398527020033 conserved cys residue [active] 398527020034 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 398527020035 hydrophobic ligand binding site; other site 398527020036 Domain of unknown function (DUF427); Region: DUF427; pfam04248 398527020037 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 398527020038 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 398527020039 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 398527020040 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 398527020041 protein binding site [polypeptide binding]; other site 398527020042 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 398527020043 protein binding site [polypeptide binding]; other site 398527020044 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 398527020045 dimer interface [polypeptide binding]; other site 398527020046 phosphorylation site [posttranslational modification] 398527020047 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527020048 ATP binding site [chemical binding]; other site 398527020049 Mg2+ binding site [ion binding]; other site 398527020050 G-X-G motif; other site 398527020051 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 398527020052 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527020053 active site 398527020054 phosphorylation site [posttranslational modification] 398527020055 intermolecular recognition site; other site 398527020056 dimerization interface [polypeptide binding]; other site 398527020057 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 398527020058 DNA binding site [nucleotide binding] 398527020059 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 398527020060 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 398527020061 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 398527020062 Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847 398527020063 active site 398527020064 catalytic triad [active] 398527020065 oxyanion hole [active] 398527020066 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 398527020067 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 398527020068 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 398527020069 ATP-grasp domain; Region: ATP-grasp; pfam02222 398527020070 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 398527020071 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 398527020072 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 398527020073 ATP binding site [chemical binding]; other site 398527020074 active site 398527020075 substrate binding site [chemical binding]; other site 398527020076 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 398527020077 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 398527020078 intersubunit interface [polypeptide binding]; other site 398527020079 active site 398527020080 zinc binding site [ion binding]; other site 398527020081 Na+ binding site [ion binding]; other site 398527020082 pyruvate kinase; Provisional; Region: PRK05826 398527020083 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 398527020084 domain interfaces; other site 398527020085 active site 398527020086 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 398527020087 Phosphoglycerate kinase; Region: PGK; pfam00162 398527020088 substrate binding site [chemical binding]; other site 398527020089 hinge regions; other site 398527020090 ADP binding site [chemical binding]; other site 398527020091 catalytic site [active] 398527020092 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 398527020093 AzlC protein; Region: AzlC; pfam03591 398527020094 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 398527020095 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 398527020096 homodimer interface [polypeptide binding]; other site 398527020097 substrate-cofactor binding pocket; other site 398527020098 catalytic residue [active] 398527020099 Zinc-finger domain; Region: zf-CHCC; cl01821 398527020100 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 398527020101 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 398527020102 putative active site [active] 398527020103 SnoaL-like domain; Region: SnoaL_3; pfam13474 398527020104 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 398527020105 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 398527020106 Protein of unknown function (DUF2946); Region: DUF2944; pfam11161 398527020107 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 398527020108 Peptidase family M48; Region: Peptidase_M48; pfam01435 398527020109 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 398527020110 trimer interface [polypeptide binding]; other site 398527020111 dimer interface [polypeptide binding]; other site 398527020112 putative active site [active] 398527020113 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 398527020114 O-Antigen ligase; Region: Wzy_C; pfam04932 398527020115 Domain of unknown function (DUF3366); Region: DUF3366; pfam11846 398527020116 Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969 398527020117 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 398527020118 Pilin (bacterial filament); Region: Pilin; pfam00114 398527020119 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 398527020120 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 398527020121 CoA binding domain; Region: CoA_binding; smart00881 398527020122 CoA-ligase; Region: Ligase_CoA; pfam00549 398527020123 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 398527020124 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 398527020125 CoA-ligase; Region: Ligase_CoA; pfam00549 398527020126 Protein of unknown function (DUF2889); Region: DUF2889; pfam11136 398527020127 RecX family; Region: RecX; cl00936 398527020128 recombinase A; Provisional; Region: recA; PRK09354 398527020129 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 398527020130 hexamer interface [polypeptide binding]; other site 398527020131 Walker A motif; other site 398527020132 ATP binding site [chemical binding]; other site 398527020133 Walker B motif; other site 398527020134 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 398527020135 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527020136 active site 398527020137 phosphorylation site [posttranslational modification] 398527020138 intermolecular recognition site; other site 398527020139 dimerization interface [polypeptide binding]; other site 398527020140 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 398527020141 DNA binding site [nucleotide binding] 398527020142 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 398527020143 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 398527020144 HAMP domain; Region: HAMP; pfam00672 398527020145 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 398527020146 dimer interface [polypeptide binding]; other site 398527020147 phosphorylation site [posttranslational modification] 398527020148 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527020149 ATP binding site [chemical binding]; other site 398527020150 Mg2+ binding site [ion binding]; other site 398527020151 G-X-G motif; other site 398527020152 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527020153 putative substrate translocation pore; other site 398527020154 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 398527020155 MarR family; Region: MarR; pfam01047 398527020156 MarR family; Region: MarR_2; cl17246 398527020157 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 398527020158 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527020159 putative substrate translocation pore; other site 398527020160 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527020161 Transcriptional regulators [Transcription]; Region: FadR; COG2186 398527020162 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527020163 DNA-binding site [nucleotide binding]; DNA binding site 398527020164 FCD domain; Region: FCD; pfam07729 398527020165 galactonate dehydratase; Provisional; Region: PRK14017 398527020166 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 398527020167 putative active site pocket [active] 398527020168 putative metal binding site [ion binding]; other site 398527020169 Uncharacterized small protein (DUF2158); Region: DUF2158; pfam09926 398527020170 CopC domain; Region: CopC; pfam04234 398527020171 Cytochrome c553 [Energy production and conversion]; Region: COG2863 398527020172 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 398527020173 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 398527020174 Cytochrome c; Region: Cytochrom_C; cl11414 398527020175 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 398527020176 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 398527020177 Cytochrome c; Region: Cytochrom_C; pfam00034 398527020178 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 398527020179 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 398527020180 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 398527020181 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 398527020182 ATP binding site [chemical binding]; other site 398527020183 Mg++ binding site [ion binding]; other site 398527020184 motif III; other site 398527020185 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 398527020186 nucleotide binding region [chemical binding]; other site 398527020187 ATP-binding site [chemical binding]; other site 398527020188 Protein of unknown function (DUF418); Region: DUF418; cl12135 398527020189 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 398527020190 dinuclear metal binding motif [ion binding]; other site 398527020191 citrate-proton symporter; Provisional; Region: PRK15075 398527020192 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527020193 putative substrate translocation pore; other site 398527020194 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 398527020195 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 398527020196 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 398527020197 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 398527020198 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 398527020199 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 398527020200 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 398527020201 DNA-binding interface [nucleotide binding]; DNA binding site 398527020202 WHG domain; Region: WHG; pfam13305 398527020203 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 398527020204 glycerol kinase; Provisional; Region: glpK; PRK00047 398527020205 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 398527020206 N- and C-terminal domain interface [polypeptide binding]; other site 398527020207 active site 398527020208 MgATP binding site [chemical binding]; other site 398527020209 catalytic site [active] 398527020210 metal binding site [ion binding]; metal-binding site 398527020211 glycerol binding site [chemical binding]; other site 398527020212 homotetramer interface [polypeptide binding]; other site 398527020213 homodimer interface [polypeptide binding]; other site 398527020214 FBP binding site [chemical binding]; other site 398527020215 protein IIAGlc interface [polypeptide binding]; other site 398527020216 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 398527020217 amphipathic channel; other site 398527020218 Asn-Pro-Ala signature motifs; other site 398527020219 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 398527020220 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 398527020221 active site 398527020222 motif I; other site 398527020223 motif II; other site 398527020224 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 398527020225 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 398527020226 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 398527020227 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 398527020228 non-specific DNA binding site [nucleotide binding]; other site 398527020229 salt bridge; other site 398527020230 sequence-specific DNA binding site [nucleotide binding]; other site 398527020231 Cupin domain; Region: Cupin_2; pfam07883 398527020232 MFS transport protein AraJ; Provisional; Region: PRK10091 398527020233 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527020234 putative substrate translocation pore; other site 398527020235 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 398527020236 dimer interface [polypeptide binding]; other site 398527020237 putative metal binding site [ion binding]; other site 398527020238 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527020239 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527020240 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 398527020241 putative effector binding pocket; other site 398527020242 dimerization interface [polypeptide binding]; other site 398527020243 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 398527020244 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 398527020245 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 398527020246 FeS/SAM binding site; other site 398527020247 TRAM domain; Region: TRAM; pfam01938 398527020248 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 398527020249 PhoH-like protein; Region: PhoH; pfam02562 398527020250 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 398527020251 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 398527020252 putative active site pocket [active] 398527020253 dimerization interface [polypeptide binding]; other site 398527020254 putative catalytic residue [active] 398527020255 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 398527020256 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 398527020257 Transporter associated domain; Region: CorC_HlyC; smart01091 398527020258 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 398527020259 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 398527020260 putative active site [active] 398527020261 catalytic triad [active] 398527020262 putative dimer interface [polypeptide binding]; other site 398527020263 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 398527020264 putative glutathione S-transferase; Provisional; Region: PRK10357 398527020265 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 398527020266 putative C-terminal domain interface [polypeptide binding]; other site 398527020267 putative GSH binding site (G-site) [chemical binding]; other site 398527020268 putative dimer interface [polypeptide binding]; other site 398527020269 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 398527020270 dimer interface [polypeptide binding]; other site 398527020271 N-terminal domain interface [polypeptide binding]; other site 398527020272 putative substrate binding pocket (H-site) [chemical binding]; other site 398527020273 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 398527020274 proline aminopeptidase P II; Provisional; Region: PRK10879 398527020275 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 398527020276 active site 398527020277 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 398527020278 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 398527020279 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 398527020280 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 398527020281 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 398527020282 FMN binding site [chemical binding]; other site 398527020283 active site 398527020284 catalytic residues [active] 398527020285 substrate binding site [chemical binding]; other site 398527020286 DNA-binding protein Fis; Provisional; Region: PRK01905 398527020287 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 398527020288 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 398527020289 purine monophosphate binding site [chemical binding]; other site 398527020290 dimer interface [polypeptide binding]; other site 398527020291 putative catalytic residues [active] 398527020292 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 398527020293 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 398527020294 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 398527020295 active site 398527020296 putative DNA-binding cleft [nucleotide binding]; other site 398527020297 dimer interface [polypeptide binding]; other site 398527020298 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 398527020299 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 398527020300 RuvA N terminal domain; Region: RuvA_N; pfam01330 398527020301 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 398527020302 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 398527020303 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527020304 Walker A motif; other site 398527020305 ATP binding site [chemical binding]; other site 398527020306 Walker B motif; other site 398527020307 arginine finger; other site 398527020308 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 398527020309 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 398527020310 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 398527020311 catalytic core [active] 398527020312 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 398527020313 putative active site [active] 398527020314 dimerization interface [polypeptide binding]; other site 398527020315 putative tRNAtyr binding site [nucleotide binding]; other site 398527020316 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 398527020317 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 398527020318 active site 398527020319 HIGH motif; other site 398527020320 dimer interface [polypeptide binding]; other site 398527020321 KMSKS motif; other site 398527020322 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 398527020323 RNA binding surface [nucleotide binding]; other site 398527020324 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 398527020325 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 398527020326 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 398527020327 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 398527020328 23S rRNA interface [nucleotide binding]; other site 398527020329 L3 interface [polypeptide binding]; other site 398527020330 OsmC-like protein; Region: OsmC; cl00767 398527020331 Protein of unknown function (DUF3025); Region: DUF3025; pfam11227 398527020332 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 398527020333 active site 398527020334 substrate binding pocket [chemical binding]; other site 398527020335 dimer interface [polypeptide binding]; other site 398527020336 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 398527020337 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 398527020338 putative active site [active] 398527020339 putative dimer interface [polypeptide binding]; other site 398527020340 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 398527020341 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 398527020342 Walker A/P-loop; other site 398527020343 ATP binding site [chemical binding]; other site 398527020344 Q-loop/lid; other site 398527020345 ABC transporter signature motif; other site 398527020346 Walker B; other site 398527020347 D-loop; other site 398527020348 H-loop/switch region; other site 398527020349 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 398527020350 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527020351 dimer interface [polypeptide binding]; other site 398527020352 conserved gate region; other site 398527020353 putative PBP binding loops; other site 398527020354 ABC-ATPase subunit interface; other site 398527020355 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 398527020356 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527020357 dimer interface [polypeptide binding]; other site 398527020358 conserved gate region; other site 398527020359 putative PBP binding loops; other site 398527020360 ABC-ATPase subunit interface; other site 398527020361 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 398527020362 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 398527020363 substrate binding pocket [chemical binding]; other site 398527020364 membrane-bound complex binding site; other site 398527020365 hinge residues; other site 398527020366 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 398527020367 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 398527020368 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 398527020369 NAD(P) binding site [chemical binding]; other site 398527020370 cell density-dependent motility repressor; Provisional; Region: PRK10082 398527020371 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527020372 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 398527020373 dimerization interface [polypeptide binding]; other site 398527020374 adenylosuccinate lyase; Provisional; Region: PRK09285 398527020375 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 398527020376 tetramer interface [polypeptide binding]; other site 398527020377 active site 398527020378 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 398527020379 ATP-binding site [chemical binding]; other site 398527020380 Gluconate-6-phosphate binding site [chemical binding]; other site 398527020381 Shikimate kinase; Region: SKI; pfam01202 398527020382 GntP family permease; Region: GntP_permease; pfam02447 398527020383 fructuronate transporter; Provisional; Region: PRK10034; cl15264 398527020384 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 398527020385 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 398527020386 active site 398527020387 intersubunit interface [polypeptide binding]; other site 398527020388 catalytic residue [active] 398527020389 phosphogluconate dehydratase; Validated; Region: PRK09054 398527020390 6-phosphogluconate dehydratase; Region: edd; TIGR01196 398527020391 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 398527020392 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 398527020393 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 398527020394 putative active site [active] 398527020395 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 398527020396 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 398527020397 ligand binding site [chemical binding]; other site 398527020398 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 398527020399 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 398527020400 trimer interface [polypeptide binding]; other site 398527020401 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 398527020402 trimer interface [polypeptide binding]; other site 398527020403 Haemagglutinin; Region: HIM; pfam05662 398527020404 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 398527020405 trimer interface [polypeptide binding]; other site 398527020406 Haemagglutinin; Region: HIM; pfam05662 398527020407 Haemagglutinin; Region: HIM; pfam05662 398527020408 Haemagglutinin; Region: HIM; pfam05662 398527020409 Haemagglutinin; Region: HIM; pfam05662 398527020410 YadA-like C-terminal region; Region: YadA; pfam03895 398527020411 SnoaL-like domain; Region: SnoaL_3; pfam13474 398527020412 SnoaL-like domain; Region: SnoaL_2; pfam12680 398527020413 Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863 398527020414 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 398527020415 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 398527020416 putative catalytic cysteine [active] 398527020417 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 398527020418 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 398527020419 Lipopolysaccharide-assembly; Region: LptE; cl01125 398527020420 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 398527020421 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 398527020422 HIGH motif; other site 398527020423 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 398527020424 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 398527020425 active site 398527020426 KMSKS motif; other site 398527020427 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 398527020428 tRNA binding surface [nucleotide binding]; other site 398527020429 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 398527020430 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 398527020431 TolR protein; Region: tolR; TIGR02801 398527020432 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 398527020433 dihydrodipicolinate reductase; Provisional; Region: PRK00048 398527020434 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 398527020435 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 398527020436 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 398527020437 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 398527020438 ferric uptake regulator; Provisional; Region: fur; PRK09462 398527020439 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 398527020440 metal binding site 2 [ion binding]; metal-binding site 398527020441 putative DNA binding helix; other site 398527020442 metal binding site 1 [ion binding]; metal-binding site 398527020443 dimer interface [polypeptide binding]; other site 398527020444 structural Zn2+ binding site [ion binding]; other site 398527020445 ureidoglycolate hydrolase; Provisional; Region: PRK13395 398527020446 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 398527020447 allantoicase; Provisional; Region: PRK13257 398527020448 Allantoicase repeat; Region: Allantoicase; pfam03561 398527020449 Allantoicase repeat; Region: Allantoicase; pfam03561 398527020450 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK13027 398527020451 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 398527020452 Transcriptional regulators [Transcription]; Region: FadR; COG2186 398527020453 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 398527020454 DNA-binding site [nucleotide binding]; DNA binding site 398527020455 FCD domain; Region: FCD; pfam07729 398527020456 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 398527020457 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 398527020458 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 398527020459 transketolase; Reviewed; Region: PRK12753 398527020460 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 398527020461 TPP-binding site [chemical binding]; other site 398527020462 dimer interface [polypeptide binding]; other site 398527020463 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 398527020464 PYR/PP interface [polypeptide binding]; other site 398527020465 dimer interface [polypeptide binding]; other site 398527020466 TPP binding site [chemical binding]; other site 398527020467 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 398527020468 spermidine synthase; Provisional; Region: PRK00811 398527020469 Spermidine synthase [Amino acid transport and metabolism]; Region: SpeE; COG0421 398527020470 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 398527020471 putative dimer interface [polypeptide binding]; other site 398527020472 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 398527020473 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 398527020474 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 398527020475 putative RNAase interaction site [polypeptide binding]; other site 398527020476 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 398527020477 active site 398527020478 barstar interaction site; other site 398527020479 putative transposase OrfB; Reviewed; Region: PHA02517 398527020480 Integrase core domain; Region: rve; pfam00665 398527020481 Integrase core domain; Region: rve_3; pfam13683 398527020482 malic enzyme; Reviewed; Region: PRK12862 398527020483 Malic enzyme, N-terminal domain; Region: malic; pfam00390 398527020484 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 398527020485 putative NAD(P) binding site [chemical binding]; other site 398527020486 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 398527020487 thiamine monophosphate kinase; Provisional; Region: PRK05731 398527020488 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 398527020489 ATP binding site [chemical binding]; other site 398527020490 dimerization interface [polypeptide binding]; other site 398527020491 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 398527020492 tetramer interfaces [polypeptide binding]; other site 398527020493 binuclear metal-binding site [ion binding]; other site 398527020494 Competence-damaged protein; Region: CinA; pfam02464 398527020495 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 398527020496 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 398527020497 active site 398527020498 dimer interface [polypeptide binding]; other site 398527020499 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 398527020500 active site 398527020501 catalytic residues [active] 398527020502 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 398527020503 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 398527020504 classical (c) SDRs; Region: SDR_c; cd05233 398527020505 NAD(P) binding site [chemical binding]; other site 398527020506 active site 398527020507 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 398527020508 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 398527020509 TM-ABC transporter signature motif; other site 398527020510 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 398527020511 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 398527020512 Walker A/P-loop; other site 398527020513 ATP binding site [chemical binding]; other site 398527020514 Q-loop/lid; other site 398527020515 ABC transporter signature motif; other site 398527020516 Walker B; other site 398527020517 D-loop; other site 398527020518 H-loop/switch region; other site 398527020519 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 398527020520 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 398527020521 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 398527020522 ligand binding site [chemical binding]; other site 398527020523 short chain dehydrogenase; Provisional; Region: PRK07063 398527020524 classical (c) SDRs; Region: SDR_c; cd05233 398527020525 NAD(P) binding site [chemical binding]; other site 398527020526 active site 398527020527 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 398527020528 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 398527020529 active site 398527020530 intersubunit interface [polypeptide binding]; other site 398527020531 catalytic residue [active] 398527020532 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 398527020533 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 398527020534 Transcriptional regulator [Transcription]; Region: IclR; COG1414 398527020535 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 398527020536 Bacterial transcriptional regulator; Region: IclR; pfam01614 398527020537 Transposase, Mutator family; Region: Transposase_mut; pfam00872 398527020538 MULE transposase domain; Region: MULE; pfam10551 398527020539 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 398527020540 Transglycosylase; Region: Transgly; cl17702 398527020541 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 398527020542 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 398527020543 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 398527020544 shikimate binding site; other site 398527020545 NAD(P) binding site [chemical binding]; other site 398527020546 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 398527020547 RNB domain; Region: RNB; pfam00773 398527020548 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 398527020549 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 398527020550 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 398527020551 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 398527020552 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 398527020553 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 398527020554 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 398527020555 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 398527020556 catalytic residues [active] 398527020557 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 398527020558 Dehydroquinase class II; Region: DHquinase_II; pfam01220 398527020559 active site 398527020560 trimer interface [polypeptide binding]; other site 398527020561 dimer interface [polypeptide binding]; other site 398527020562 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 398527020563 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 398527020564 carboxyltransferase (CT) interaction site; other site 398527020565 biotinylation site [posttranslational modification]; other site 398527020566 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 398527020567 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 398527020568 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 398527020569 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 398527020570 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 398527020571 DNA methylase; Region: N6_N4_Mtase; cl17433 398527020572 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 398527020573 S-adenosylmethionine binding site [chemical binding]; other site 398527020574 MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098 398527020575 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 398527020576 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 398527020577 dimer interface [polypeptide binding]; other site 398527020578 catalytic triad [active] 398527020579 peroxidatic and resolving cysteines [active] 398527020580 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 398527020581 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 398527020582 substrate binding site [chemical binding]; other site 398527020583 ATP binding site [chemical binding]; other site 398527020584 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 398527020585 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 398527020586 dimer interface [polypeptide binding]; other site 398527020587 putative radical transfer pathway; other site 398527020588 diiron center [ion binding]; other site 398527020589 tyrosyl radical; other site 398527020590 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 398527020591 ATP cone domain; Region: ATP-cone; pfam03477 398527020592 Class I ribonucleotide reductase; Region: RNR_I; cd01679 398527020593 active site 398527020594 dimer interface [polypeptide binding]; other site 398527020595 catalytic residues [active] 398527020596 effector binding site; other site 398527020597 R2 peptide binding site; other site 398527020598 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 398527020599 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 398527020600 amidase catalytic site [active] 398527020601 Zn binding residues [ion binding]; other site 398527020602 substrate binding site [chemical binding]; other site 398527020603 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 398527020604 signal recognition particle protein; Provisional; Region: PRK10867 398527020605 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 398527020606 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 398527020607 P loop; other site 398527020608 GTP binding site [chemical binding]; other site 398527020609 Signal peptide binding domain; Region: SRP_SPB; pfam02978 398527020610 Methyl-coenzyme M reductase operon protein C; Region: MCR_C; cl01674 398527020611 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 398527020612 active site 398527020613 MarC family integral membrane protein; Region: MarC; cl00919 398527020614 prolyl-tRNA synthetase; Provisional; Region: PRK09194 398527020615 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 398527020616 dimer interface [polypeptide binding]; other site 398527020617 motif 1; other site 398527020618 active site 398527020619 motif 2; other site 398527020620 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 398527020621 putative deacylase active site [active] 398527020622 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 398527020623 active site 398527020624 motif 3; other site 398527020625 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 398527020626 anticodon binding site; other site 398527020627 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 398527020628 putative active site [active] 398527020629 Ap4A binding site [chemical binding]; other site 398527020630 nudix motif; other site 398527020631 putative metal binding site [ion binding]; other site 398527020632 CNP1-like family; Region: CNP1; pfam08750 398527020633 gamma-glutamyl kinase; Provisional; Region: PRK05429 398527020634 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 398527020635 nucleotide binding site [chemical binding]; other site 398527020636 homotetrameric interface [polypeptide binding]; other site 398527020637 putative phosphate binding site [ion binding]; other site 398527020638 putative allosteric binding site; other site 398527020639 PUA domain; Region: PUA; pfam01472 398527020640 GTPase CgtA; Reviewed; Region: obgE; PRK12299 398527020641 GTP1/OBG; Region: GTP1_OBG; pfam01018 398527020642 Obg GTPase; Region: Obg; cd01898 398527020643 G1 box; other site 398527020644 GTP/Mg2+ binding site [chemical binding]; other site 398527020645 Switch I region; other site 398527020646 G2 box; other site 398527020647 G3 box; other site 398527020648 Switch II region; other site 398527020649 G4 box; other site 398527020650 G5 box; other site 398527020651 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 398527020652 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 398527020653 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 398527020654 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 398527020655 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 398527020656 substrate binding pocket [chemical binding]; other site 398527020657 chain length determination region; other site 398527020658 substrate-Mg2+ binding site; other site 398527020659 catalytic residues [active] 398527020660 aspartate-rich region 1; other site 398527020661 active site lid residues [active] 398527020662 aspartate-rich region 2; other site 398527020663 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 398527020664 Domain of unknown function DUF21; Region: DUF21; pfam01595 398527020665 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 398527020666 Transporter associated domain; Region: CorC_HlyC; smart01091 398527020667 Type II/IV secretion system protein; Region: T2SE; pfam00437 398527020668 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 398527020669 Walker A motif; other site 398527020670 ATP binding site [chemical binding]; other site 398527020671 Walker B motif; other site 398527020672 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 398527020673 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 398527020674 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 398527020675 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 398527020676 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 398527020677 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 398527020678 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 398527020679 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 398527020680 CoA-binding site [chemical binding]; other site 398527020681 ATP-binding [chemical binding]; other site 398527020682 hypothetical protein; Provisional; Region: PRK05287 398527020683 Domain of unknown function (DUF329); Region: DUF329; pfam03884 398527020684 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 398527020685 active site 398527020686 8-oxo-dGMP binding site [chemical binding]; other site 398527020687 nudix motif; other site 398527020688 metal binding site [ion binding]; metal-binding site 398527020689 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 398527020690 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527020691 Walker A motif; other site 398527020692 ATP binding site [chemical binding]; other site 398527020693 Walker B motif; other site 398527020694 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 398527020695 heterotetramer interface [polypeptide binding]; other site 398527020696 active site pocket [active] 398527020697 cleavage site 398527020698 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 398527020699 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 398527020700 SEC-C motif; Region: SEC-C; pfam02810 398527020701 Protein of unknown function (DUF721); Region: DUF721; pfam05258 398527020702 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 398527020703 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 398527020704 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 398527020705 catalytic triad [active] 398527020706 dimer interface [polypeptide binding]; other site 398527020707 cell division protein FtsZ; Validated; Region: PRK09330 398527020708 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 398527020709 nucleotide binding site [chemical binding]; other site 398527020710 SulA interaction site; other site 398527020711 cell division protein FtsA; Region: ftsA; TIGR01174 398527020712 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 398527020713 nucleotide binding site [chemical binding]; other site 398527020714 Cell division protein FtsA; Region: FtsA; pfam14450 398527020715 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 398527020716 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 398527020717 Cell division protein FtsQ; Region: FtsQ; pfam03799 398527020718 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 398527020719 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 398527020720 ATP-grasp domain; Region: ATP-grasp_4; cl17255 398527020721 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 398527020722 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 398527020723 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 398527020724 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 398527020725 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 398527020726 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 398527020727 active site 398527020728 homodimer interface [polypeptide binding]; other site 398527020729 cell division protein FtsW; Region: ftsW; TIGR02614 398527020730 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02006 398527020731 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 398527020732 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 398527020733 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 398527020734 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 398527020735 Mg++ binding site [ion binding]; other site 398527020736 putative catalytic motif [active] 398527020737 putative substrate binding site [chemical binding]; other site 398527020738 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 398527020739 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 398527020740 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 398527020741 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 398527020742 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 398527020743 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 398527020744 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 398527020745 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 398527020746 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 398527020747 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 398527020748 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 398527020749 Cell division protein FtsL; Region: FtsL; cl11433 398527020750 MraW methylase family; Region: Methyltransf_5; cl17771 398527020751 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 398527020752 cell division protein MraZ; Reviewed; Region: PRK00326 398527020753 MraZ protein; Region: MraZ; pfam02381 398527020754 MraZ protein; Region: MraZ; pfam02381 398527020755 Demethoxyubiquinone hydroxylase, ferritin-like diiron-binding domain; Region: DMQH; cd01042 398527020756 diiron binding motif [ion binding]; other site 398527020757 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 398527020758 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 398527020759 trimer interface [polypeptide binding]; other site 398527020760 eyelet of channel; other site 398527020761 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 398527020762 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 398527020763 acyl-activating enzyme (AAE) consensus motif; other site 398527020764 putative AMP binding site [chemical binding]; other site 398527020765 putative active site [active] 398527020766 putative CoA binding site [chemical binding]; other site 398527020767 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 398527020768 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 398527020769 putative [4Fe-4S] binding site [ion binding]; other site 398527020770 putative molybdopterin cofactor binding site [chemical binding]; other site 398527020771 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 398527020772 putative molybdopterin cofactor binding site; other site 398527020773 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 398527020774 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 398527020775 metal binding site [ion binding]; metal-binding site 398527020776 putative dimer interface [polypeptide binding]; other site 398527020777 enoyl-CoA hydratase; Provisional; Region: PRK05862 398527020778 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 398527020779 substrate binding site [chemical binding]; other site 398527020780 oxyanion hole (OAH) forming residues; other site 398527020781 trimer interface [polypeptide binding]; other site 398527020782 phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288 398527020783 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 398527020784 NAD(P) binding site [chemical binding]; other site 398527020785 catalytic residues [active] 398527020786 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 398527020787 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 398527020788 dimer interface [polypeptide binding]; other site 398527020789 active site 398527020790 enoyl-CoA hydratase; Provisional; Region: PRK08140 398527020791 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 398527020792 substrate binding site [chemical binding]; other site 398527020793 oxyanion hole (OAH) forming residues; other site 398527020794 trimer interface [polypeptide binding]; other site 398527020795 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 398527020796 CoenzymeA binding site [chemical binding]; other site 398527020797 subunit interaction site [polypeptide binding]; other site 398527020798 PHB binding site; other site 398527020799 Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913 398527020800 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 398527020801 active site 398527020802 AMP binding site [chemical binding]; other site 398527020803 homodimer interface [polypeptide binding]; other site 398527020804 acyl-activating enzyme (AAE) consensus motif; other site 398527020805 CoA binding site [chemical binding]; other site 398527020806 Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821 398527020807 MltA specific insert domain; Region: MltA; smart00925 398527020808 3D domain; Region: 3D; pfam06725 398527020809 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 398527020810 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 398527020811 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 398527020812 substrate binding site [chemical binding]; other site 398527020813 hexamer interface [polypeptide binding]; other site 398527020814 metal binding site [ion binding]; metal-binding site 398527020815 phosphoglycolate phosphatase; Provisional; Region: PRK13222 398527020816 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 398527020817 motif II; other site 398527020818 anthranilate synthase component I; Provisional; Region: PRK13565 398527020819 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 398527020820 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 398527020821 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 398527020822 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 398527020823 glutamine binding [chemical binding]; other site 398527020824 catalytic triad [active] 398527020825 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 398527020826 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 398527020827 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 398527020828 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 398527020829 active site 398527020830 ribulose/triose binding site [chemical binding]; other site 398527020831 phosphate binding site [ion binding]; other site 398527020832 substrate (anthranilate) binding pocket [chemical binding]; other site 398527020833 product (indole) binding pocket [chemical binding]; other site 398527020834 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 398527020835 putative active site [active] 398527020836 putative metal binding residues [ion binding]; other site 398527020837 signature motif; other site 398527020838 putative triphosphate binding site [ion binding]; other site 398527020839 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 398527020840 ligand binding site [chemical binding]; other site 398527020841 active site 398527020842 UGI interface [polypeptide binding]; other site 398527020843 catalytic site [active] 398527020844 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 398527020845 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 398527020846 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 398527020847 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 398527020848 PDZ domain; Region: PDZ_2; pfam13180 398527020849 protein binding site [polypeptide binding]; other site 398527020850 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 398527020851 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 398527020852 dimerization domain [polypeptide binding]; other site 398527020853 dimer interface [polypeptide binding]; other site 398527020854 catalytic residues [active] 398527020855 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608 398527020856 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 398527020857 GTP-binding protein YchF; Reviewed; Region: PRK09601 398527020858 YchF GTPase; Region: YchF; cd01900 398527020859 G1 box; other site 398527020860 GTP/Mg2+ binding site [chemical binding]; other site 398527020861 Switch I region; other site 398527020862 G2 box; other site 398527020863 Switch II region; other site 398527020864 G3 box; other site 398527020865 G4 box; other site 398527020866 G5 box; other site 398527020867 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 398527020868 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 398527020869 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial protein Rv2277c and similar proteins; Region: GDPD_Rv2277c_like; cd08580 398527020870 putative active site [active] 398527020871 catalytic site [active] 398527020872 putative metal binding site [ion binding]; other site 398527020873 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 398527020874 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 398527020875 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 398527020876 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527020877 dimer interface [polypeptide binding]; other site 398527020878 conserved gate region; other site 398527020879 putative PBP binding loops; other site 398527020880 ABC-ATPase subunit interface; other site 398527020881 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 398527020882 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527020883 dimer interface [polypeptide binding]; other site 398527020884 conserved gate region; other site 398527020885 putative PBP binding loops; other site 398527020886 ABC-ATPase subunit interface; other site 398527020887 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 398527020888 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 398527020889 Walker A/P-loop; other site 398527020890 ATP binding site [chemical binding]; other site 398527020891 Q-loop/lid; other site 398527020892 ABC transporter signature motif; other site 398527020893 Walker B; other site 398527020894 D-loop; other site 398527020895 H-loop/switch region; other site 398527020896 TOBE domain; Region: TOBE_2; pfam08402 398527020897 Protein of unknown function (DUF3761); Region: DUF3761; pfam12587 398527020898 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 398527020899 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 398527020900 Walker A/P-loop; other site 398527020901 ATP binding site [chemical binding]; other site 398527020902 Q-loop/lid; other site 398527020903 ABC transporter signature motif; other site 398527020904 Walker B; other site 398527020905 D-loop; other site 398527020906 H-loop/switch region; other site 398527020907 ABC transporter; Region: ABC_tran_2; pfam12848 398527020908 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 398527020909 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 398527020910 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 398527020911 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 398527020912 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 398527020913 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 398527020914 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 398527020915 active site 398527020916 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 398527020917 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527020918 active site 398527020919 phosphorylation site [posttranslational modification] 398527020920 intermolecular recognition site; other site 398527020921 dimerization interface [polypeptide binding]; other site 398527020922 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 398527020923 DNA binding site [nucleotide binding] 398527020924 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 398527020925 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 398527020926 tRNA; other site 398527020927 putative tRNA binding site [nucleotide binding]; other site 398527020928 putative NADP binding site [chemical binding]; other site 398527020929 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 398527020930 peptide chain release factor 1; Validated; Region: prfA; PRK00591 398527020931 This domain is found in peptide chain release factors; Region: PCRF; smart00937 398527020932 RF-1 domain; Region: RF-1; pfam00472 398527020933 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 398527020934 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 398527020935 S-adenosylmethionine binding site [chemical binding]; other site 398527020936 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 398527020937 putative GSH binding site [chemical binding]; other site 398527020938 catalytic residues [active] 398527020939 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 398527020940 Flavoprotein; Region: Flavoprotein; pfam02441 398527020941 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 398527020942 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 398527020943 putative active site [active] 398527020944 metal binding site [ion binding]; metal-binding site 398527020945 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 398527020946 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 398527020947 DNA-binding site [nucleotide binding]; DNA binding site 398527020948 RNA-binding motif; other site 398527020949 putative chaperone; Provisional; Region: PRK11678 398527020950 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 398527020951 nucleotide binding site [chemical binding]; other site 398527020952 putative NEF/HSP70 interaction site [polypeptide binding]; other site 398527020953 SBD interface [polypeptide binding]; other site 398527020954 benzoate transport; Region: 2A0115; TIGR00895 398527020955 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527020956 putative substrate translocation pore; other site 398527020957 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527020958 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 398527020959 putative FMN binding site [chemical binding]; other site 398527020960 Major Facilitator Superfamily; Region: MFS_1; pfam07690 398527020961 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527020962 putative substrate translocation pore; other site 398527020963 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 398527020964 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 398527020965 Protein of unknown function (DUF1415); Region: DUF1415; pfam07209 398527020966 Methyltransferase domain; Region: Methyltransf_32; pfam13679 398527020967 Methyltransferase domain; Region: Methyltransf_31; pfam13847 398527020968 Protein of unknown function (DUF1059); Region: DUF1059; cl02284 398527020969 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 398527020970 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 398527020971 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 398527020972 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 398527020973 S-adenosylmethionine binding site [chemical binding]; other site 398527020974 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 398527020975 stringent starvation protein A; Provisional; Region: sspA; PRK09481 398527020976 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 398527020977 C-terminal domain interface [polypeptide binding]; other site 398527020978 putative GSH binding site (G-site) [chemical binding]; other site 398527020979 dimer interface [polypeptide binding]; other site 398527020980 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 398527020981 dimer interface [polypeptide binding]; other site 398527020982 N-terminal domain interface [polypeptide binding]; other site 398527020983 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 398527020984 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 398527020985 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 398527020986 Qi binding site; other site 398527020987 intrachain domain interface; other site 398527020988 interchain domain interface [polypeptide binding]; other site 398527020989 heme bH binding site [chemical binding]; other site 398527020990 heme bL binding site [chemical binding]; other site 398527020991 Qo binding site; other site 398527020992 interchain domain interface [polypeptide binding]; other site 398527020993 intrachain domain interface; other site 398527020994 Qi binding site; other site 398527020995 Cytochrome b(C-terminal)/b6/petD; Region: Cytochrom_B_C; pfam00032 398527020996 Qo binding site; other site 398527020997 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 398527020998 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 398527020999 [2Fe-2S] cluster binding site [ion binding]; other site 398527021000 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 398527021001 Uncharacterized conserved protein [Function unknown]; Region: COG0327 398527021002 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 398527021003 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 398527021004 protein binding site [polypeptide binding]; other site 398527021005 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 398527021006 sec-independent translocase; Provisional; Region: tatB; PRK01919 398527021007 twin arginine translocase protein A; Provisional; Region: tatA; PRK02958 398527021008 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 398527021009 nucleotide binding site/active site [active] 398527021010 HIT family signature motif; other site 398527021011 catalytic residue [active] 398527021012 Predicted membrane protein [Function unknown]; Region: COG3671 398527021013 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 398527021014 metal binding site [ion binding]; metal-binding site 398527021015 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 398527021016 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 398527021017 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 398527021018 substrate binding site [chemical binding]; other site 398527021019 glutamase interaction surface [polypeptide binding]; other site 398527021020 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 398527021021 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 398527021022 catalytic residues [active] 398527021023 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 398527021024 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 398527021025 putative active site [active] 398527021026 oxyanion strand; other site 398527021027 catalytic triad [active] 398527021028 MarC family integral membrane protein; Region: MarC; cl00919 398527021029 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 398527021030 putative active site pocket [active] 398527021031 4-fold oligomerization interface [polypeptide binding]; other site 398527021032 metal binding residues [ion binding]; metal-binding site 398527021033 3-fold/trimer interface [polypeptide binding]; other site 398527021034 histidinol-phosphate aminotransferase; Provisional; Region: PRK04870 398527021035 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 398527021036 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527021037 homodimer interface [polypeptide binding]; other site 398527021038 catalytic residue [active] 398527021039 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 398527021040 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 398527021041 NAD binding site [chemical binding]; other site 398527021042 dimerization interface [polypeptide binding]; other site 398527021043 product binding site; other site 398527021044 substrate binding site [chemical binding]; other site 398527021045 zinc binding site [ion binding]; other site 398527021046 catalytic residues [active] 398527021047 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 398527021048 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 398527021049 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 398527021050 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 398527021051 hinge; other site 398527021052 active site 398527021053 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 398527021054 ABC-2 type transporter; Region: ABC2_membrane; cl17235 398527021055 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 398527021056 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 398527021057 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 398527021058 Walker A/P-loop; other site 398527021059 ATP binding site [chemical binding]; other site 398527021060 Q-loop/lid; other site 398527021061 ABC transporter signature motif; other site 398527021062 Walker B; other site 398527021063 D-loop; other site 398527021064 H-loop/switch region; other site 398527021065 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 398527021066 anti sigma factor interaction site; other site 398527021067 regulatory phosphorylation site [posttranslational modification]; other site 398527021068 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 398527021069 VacJ like lipoprotein; Region: VacJ; cl01073 398527021070 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 398527021071 mce related protein; Region: MCE; pfam02470 398527021072 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 398527021073 Permease; Region: Permease; pfam02405 398527021074 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 398527021075 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 398527021076 Walker A/P-loop; other site 398527021077 ATP binding site [chemical binding]; other site 398527021078 Q-loop/lid; other site 398527021079 ABC transporter signature motif; other site 398527021080 Walker B; other site 398527021081 D-loop; other site 398527021082 H-loop/switch region; other site 398527021083 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 398527021084 thiamine phosphate binding site [chemical binding]; other site 398527021085 active site 398527021086 pyrophosphate binding site [ion binding]; other site 398527021087 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 398527021088 ThiS interaction site; other site 398527021089 putative active site [active] 398527021090 tetramer interface [polypeptide binding]; other site 398527021091 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 398527021092 thiS-thiF/thiG interaction site; other site 398527021093 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 398527021094 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 398527021095 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 398527021096 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 398527021097 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 398527021098 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 398527021099 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 398527021100 NAD(P) binding site [chemical binding]; other site 398527021101 active site 398527021102 osmolarity response regulator; Provisional; Region: ompR; PRK09468 398527021103 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527021104 active site 398527021105 phosphorylation site [posttranslational modification] 398527021106 intermolecular recognition site; other site 398527021107 dimerization interface [polypeptide binding]; other site 398527021108 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 398527021109 DNA binding site [nucleotide binding] 398527021110 Flagellar L-ring protein; Region: FlgH; pfam02107 398527021111 osmolarity response regulator; Provisional; Region: ompR; PRK09468 398527021112 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527021113 active site 398527021114 phosphorylation site [posttranslational modification] 398527021115 intermolecular recognition site; other site 398527021116 dimerization interface [polypeptide binding]; other site 398527021117 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 398527021118 DNA binding site [nucleotide binding] 398527021119 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 398527021120 dimerization interface [polypeptide binding]; other site 398527021121 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 398527021122 dimer interface [polypeptide binding]; other site 398527021123 phosphorylation site [posttranslational modification] 398527021124 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527021125 ATP binding site [chemical binding]; other site 398527021126 Mg2+ binding site [ion binding]; other site 398527021127 G-X-G motif; other site 398527021128 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 398527021129 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 398527021130 benzoate transport; Region: 2A0115; TIGR00895 398527021131 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527021132 putative substrate translocation pore; other site 398527021133 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 398527021134 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 398527021135 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 398527021136 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 398527021137 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 398527021138 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 398527021139 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 398527021140 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 398527021141 active site 398527021142 dimer interface [polypeptide binding]; other site 398527021143 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 398527021144 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 398527021145 active site 398527021146 FMN binding site [chemical binding]; other site 398527021147 substrate binding site [chemical binding]; other site 398527021148 3Fe-4S cluster binding site [ion binding]; other site 398527021149 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 398527021150 domain interface; other site 398527021151 Transposase IS200 like; Region: Y1_Tnp; cl00848 398527021152 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 398527021153 Bacterial protein of unknown function (DUF883); Region: DUF883; pfam05957 398527021154 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 398527021155 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 398527021156 Zn2+ binding site [ion binding]; other site 398527021157 Mg2+ binding site [ion binding]; other site 398527021158 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 398527021159 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 398527021160 active site 398527021161 dimer interface [polypeptide binding]; other site 398527021162 metal binding site [ion binding]; metal-binding site 398527021163 shikimate kinase; Reviewed; Region: aroK; PRK00131 398527021164 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 398527021165 ADP binding site [chemical binding]; other site 398527021166 magnesium binding site [ion binding]; other site 398527021167 putative shikimate binding site; other site 398527021168 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 398527021169 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 398527021170 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 398527021171 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 398527021172 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 398527021173 Transglycosylase; Region: Transgly; pfam00912 398527021174 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 398527021175 frataxin-like protein; Provisional; Region: cyaY; PRK00446 398527021176 diaminopimelate decarboxylase; Region: lysA; TIGR01048 398527021177 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 398527021178 active site 398527021179 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 398527021180 substrate binding site [chemical binding]; other site 398527021181 catalytic residues [active] 398527021182 dimer interface [polypeptide binding]; other site 398527021183 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 398527021184 TMAO/DMSO reductase; Reviewed; Region: PRK05363 398527021185 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 398527021186 Moco binding site; other site 398527021187 metal coordination site [ion binding]; other site 398527021188 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 398527021189 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 398527021190 ResB-like family; Region: ResB; pfam05140 398527021191 ResB-like family; Region: ResB; pfam05140 398527021192 Cytochrome c553 [Energy production and conversion]; Region: COG2863 398527021193 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 398527021194 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 398527021195 Cytochrome c; Region: Cytochrom_C; cl11414 398527021196 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 398527021197 G1 box; other site 398527021198 GTP/Mg2+ binding site [chemical binding]; other site 398527021199 Switch I region; other site 398527021200 G2 box; other site 398527021201 G3 box; other site 398527021202 Switch II region; other site 398527021203 G4 box; other site 398527021204 G5 box; other site 398527021205 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 398527021206 dimer interface [polypeptide binding]; other site 398527021207 active site 398527021208 aspartate-rich active site metal binding site; other site 398527021209 allosteric magnesium binding site [ion binding]; other site 398527021210 Schiff base residues; other site 398527021211 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 398527021212 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 398527021213 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 398527021214 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 398527021215 DsbD alpha interface [polypeptide binding]; other site 398527021216 catalytic residues [active] 398527021217 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 398527021218 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 398527021219 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 398527021220 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 398527021221 alphaNTD homodimer interface [polypeptide binding]; other site 398527021222 alphaNTD - beta interaction site [polypeptide binding]; other site 398527021223 alphaNTD - beta' interaction site [polypeptide binding]; other site 398527021224 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 398527021225 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 398527021226 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 398527021227 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 398527021228 RNA binding surface [nucleotide binding]; other site 398527021229 30S ribosomal protein S11; Validated; Region: PRK05309 398527021230 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 398527021231 30S ribosomal protein S13; Region: bact_S13; TIGR03631 398527021232 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 398527021233 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 398527021234 rRNA binding site [nucleotide binding]; other site 398527021235 predicted 30S ribosome binding site; other site 398527021236 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 398527021237 SecY translocase; Region: SecY; pfam00344 398527021238 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 398527021239 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 398527021240 23S rRNA binding site [nucleotide binding]; other site 398527021241 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 398527021242 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 398527021243 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 398527021244 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 398527021245 5S rRNA interface [nucleotide binding]; other site 398527021246 L27 interface [polypeptide binding]; other site 398527021247 23S rRNA interface [nucleotide binding]; other site 398527021248 L5 interface [polypeptide binding]; other site 398527021249 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 398527021250 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 398527021251 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 398527021252 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 398527021253 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 398527021254 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 398527021255 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 398527021256 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 398527021257 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 398527021258 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 398527021259 RNA binding site [nucleotide binding]; other site 398527021260 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 398527021261 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 398527021262 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 398527021263 23S rRNA interface [nucleotide binding]; other site 398527021264 putative translocon interaction site; other site 398527021265 signal recognition particle (SRP54) interaction site; other site 398527021266 L23 interface [polypeptide binding]; other site 398527021267 trigger factor interaction site; other site 398527021268 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 398527021269 23S rRNA interface [nucleotide binding]; other site 398527021270 5S rRNA interface [nucleotide binding]; other site 398527021271 putative antibiotic binding site [chemical binding]; other site 398527021272 L25 interface [polypeptide binding]; other site 398527021273 L27 interface [polypeptide binding]; other site 398527021274 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 398527021275 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 398527021276 G-X-X-G motif; other site 398527021277 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 398527021278 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 398527021279 putative translocon binding site; other site 398527021280 protein-rRNA interface [nucleotide binding]; other site 398527021281 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 398527021282 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 398527021283 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 398527021284 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 398527021285 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 398527021286 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 398527021287 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 398527021288 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 398527021289 elongation factor Tu; Reviewed; Region: PRK00049 398527021290 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 398527021291 G1 box; other site 398527021292 GEF interaction site [polypeptide binding]; other site 398527021293 GTP/Mg2+ binding site [chemical binding]; other site 398527021294 Switch I region; other site 398527021295 G2 box; other site 398527021296 G3 box; other site 398527021297 Switch II region; other site 398527021298 G4 box; other site 398527021299 G5 box; other site 398527021300 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 398527021301 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 398527021302 Antibiotic Binding Site [chemical binding]; other site 398527021303 elongation factor G; Reviewed; Region: PRK00007 398527021304 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 398527021305 G1 box; other site 398527021306 putative GEF interaction site [polypeptide binding]; other site 398527021307 GTP/Mg2+ binding site [chemical binding]; other site 398527021308 Switch I region; other site 398527021309 G2 box; other site 398527021310 G3 box; other site 398527021311 Switch II region; other site 398527021312 G4 box; other site 398527021313 G5 box; other site 398527021314 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 398527021315 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 398527021316 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 398527021317 30S ribosomal protein S7; Validated; Region: PRK05302 398527021318 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 398527021319 S17 interaction site [polypeptide binding]; other site 398527021320 S8 interaction site; other site 398527021321 16S rRNA interaction site [nucleotide binding]; other site 398527021322 streptomycin interaction site [chemical binding]; other site 398527021323 23S rRNA interaction site [nucleotide binding]; other site 398527021324 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 398527021325 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 398527021326 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 398527021327 ATP binding site [chemical binding]; other site 398527021328 putative Mg++ binding site [ion binding]; other site 398527021329 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 398527021330 nucleotide binding region [chemical binding]; other site 398527021331 ATP-binding site [chemical binding]; other site 398527021332 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 398527021333 HRDC domain; Region: HRDC; pfam00570 398527021334 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 398527021335 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 398527021336 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 398527021337 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 398527021338 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 398527021339 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 398527021340 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 398527021341 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 398527021342 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 398527021343 DNA binding site [nucleotide binding] 398527021344 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 398527021345 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 398527021346 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 398527021347 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 398527021348 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 398527021349 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 398527021350 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 398527021351 RPB3 interaction site [polypeptide binding]; other site 398527021352 RPB1 interaction site [polypeptide binding]; other site 398527021353 RPB11 interaction site [polypeptide binding]; other site 398527021354 RPB10 interaction site [polypeptide binding]; other site 398527021355 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 398527021356 peripheral dimer interface [polypeptide binding]; other site 398527021357 core dimer interface [polypeptide binding]; other site 398527021358 L10 interface [polypeptide binding]; other site 398527021359 L11 interface [polypeptide binding]; other site 398527021360 putative EF-Tu interaction site [polypeptide binding]; other site 398527021361 putative EF-G interaction site [polypeptide binding]; other site 398527021362 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 398527021363 23S rRNA interface [nucleotide binding]; other site 398527021364 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 398527021365 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 398527021366 mRNA/rRNA interface [nucleotide binding]; other site 398527021367 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 398527021368 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 398527021369 23S rRNA interface [nucleotide binding]; other site 398527021370 L7/L12 interface [polypeptide binding]; other site 398527021371 putative thiostrepton binding site; other site 398527021372 L25 interface [polypeptide binding]; other site 398527021373 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 398527021374 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 398527021375 putative homodimer interface [polypeptide binding]; other site 398527021376 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 398527021377 heterodimer interface [polypeptide binding]; other site 398527021378 homodimer interface [polypeptide binding]; other site 398527021379 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 398527021380 elongation factor Tu; Reviewed; Region: PRK00049 398527021381 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 398527021382 G1 box; other site 398527021383 GEF interaction site [polypeptide binding]; other site 398527021384 GTP/Mg2+ binding site [chemical binding]; other site 398527021385 Switch I region; other site 398527021386 G2 box; other site 398527021387 G3 box; other site 398527021388 Switch II region; other site 398527021389 G4 box; other site 398527021390 G5 box; other site 398527021391 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 398527021392 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 398527021393 Antibiotic Binding Site [chemical binding]; other site 398527021394 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 398527021395 active site 398527021396 catalytic triad [active] 398527021397 oxyanion hole [active] 398527021398 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 398527021399 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 398527021400 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 398527021401 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 398527021402 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 398527021403 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 398527021404 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 398527021405 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 398527021406 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 398527021407 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 398527021408 FAD binding pocket [chemical binding]; other site 398527021409 FAD binding motif [chemical binding]; other site 398527021410 phosphate binding motif [ion binding]; other site 398527021411 beta-alpha-beta structure motif; other site 398527021412 NAD(p) ribose binding residues [chemical binding]; other site 398527021413 NAD binding pocket [chemical binding]; other site 398527021414 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 398527021415 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 398527021416 catalytic loop [active] 398527021417 iron binding site [ion binding]; other site 398527021418 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 398527021419 Protein of unknown function; Region: DUF3658; pfam12395 398527021420 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 398527021421 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 398527021422 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 398527021423 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 398527021424 Coenzyme A binding pocket [chemical binding]; other site 398527021425 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 398527021426 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 398527021427 putative DNA binding site [nucleotide binding]; other site 398527021428 putative Zn2+ binding site [ion binding]; other site 398527021429 AsnC family; Region: AsnC_trans_reg; pfam01037 398527021430 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 398527021431 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 398527021432 dimer interface [polypeptide binding]; other site 398527021433 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 398527021434 active site 398527021435 Fe binding site [ion binding]; other site 398527021436 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 398527021437 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 398527021438 dimer interface [polypeptide binding]; other site 398527021439 PYR/PP interface [polypeptide binding]; other site 398527021440 TPP binding site [chemical binding]; other site 398527021441 substrate binding site [chemical binding]; other site 398527021442 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 398527021443 TPP-binding site; other site 398527021444 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 398527021445 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 398527021446 Malic enzyme, N-terminal domain; Region: malic; pfam00390 398527021447 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 398527021448 putative NAD(P) binding site [chemical binding]; other site 398527021449 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 398527021450 benzoate transport; Region: 2A0115; TIGR00895 398527021451 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527021452 putative substrate translocation pore; other site 398527021453 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 398527021454 active site 398527021455 transcriptional regulator RcsB; Provisional; Region: PRK10840 398527021456 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527021457 active site 398527021458 phosphorylation site [posttranslational modification] 398527021459 intermolecular recognition site; other site 398527021460 dimerization interface [polypeptide binding]; other site 398527021461 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 398527021462 DNA binding residues [nucleotide binding] 398527021463 dimerization interface [polypeptide binding]; other site 398527021464 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 398527021465 substrate binding site [chemical binding]; other site 398527021466 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 398527021467 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 398527021468 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 398527021469 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 398527021470 Protein of unknown function (DUF2957); Region: DUF2957; pfam11170 398527021471 Protein of unknown function (DUF2957); Region: DUF2957; pfam11170 398527021472 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 398527021473 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 398527021474 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 398527021475 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 398527021476 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 398527021477 Uncharacterized conserved protein [Function unknown]; Region: COG1656 398527021478 Protein of unknown function DUF82; Region: DUF82; pfam01927 398527021479 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 398527021480 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 398527021481 Bacterial transcriptional regulator; Region: IclR; pfam01614 398527021482 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 398527021483 EamA-like transporter family; Region: EamA; pfam00892 398527021484 EamA-like transporter family; Region: EamA; pfam00892 398527021485 Uncharacterized protein conserved in bacteria (DUF2242); Region: DUF2242; pfam10001 398527021486 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 398527021487 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 398527021488 N-acetyl-D-glucosamine binding site [chemical binding]; other site 398527021489 catalytic residue [active] 398527021490 Predicted transcriptional regulator [Transcription]; Region: COG2378 398527021491 HTH domain; Region: HTH_11; pfam08279 398527021492 WYL domain; Region: WYL; pfam13280 398527021493 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 398527021494 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 398527021495 putative C-terminal domain interface [polypeptide binding]; other site 398527021496 putative GSH binding site (G-site) [chemical binding]; other site 398527021497 putative dimer interface [polypeptide binding]; other site 398527021498 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 398527021499 dimer interface [polypeptide binding]; other site 398527021500 N-terminal domain interface [polypeptide binding]; other site 398527021501 putative substrate binding pocket (H-site) [chemical binding]; other site 398527021502 Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363 398527021503 Response regulator receiver domain; Region: Response_reg; pfam00072 398527021504 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527021505 active site 398527021506 phosphorylation site [posttranslational modification] 398527021507 intermolecular recognition site; other site 398527021508 dimerization interface [polypeptide binding]; other site 398527021509 Protein of unknown function (DUF429); Region: DUF429; pfam04250 398527021510 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527021511 Major Facilitator Superfamily; Region: MFS_1; pfam07690 398527021512 putative substrate translocation pore; other site 398527021513 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 398527021514 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 398527021515 putative Cl- selectivity filter; other site 398527021516 putative pore gating glutamate residue; other site 398527021517 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 398527021518 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 398527021519 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 398527021520 P loop; other site 398527021521 Nucleotide binding site [chemical binding]; other site 398527021522 DTAP/Switch II; other site 398527021523 Switch I; other site 398527021524 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 398527021525 DTAP/Switch II; other site 398527021526 Switch I; other site 398527021527 Protein of unknown function (DUF1504); Region: DUF1504; pfam07399 398527021528 H-NS histone family; Region: Histone_HNS; pfam00816 398527021529 H-NS histone family; Region: Histone_HNS; pfam00816 398527021530 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 398527021531 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 398527021532 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 398527021533 trimer interface [polypeptide binding]; other site 398527021534 eyelet of channel; other site 398527021535 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527021536 D-galactonate transporter; Region: 2A0114; TIGR00893 398527021537 putative substrate translocation pore; other site 398527021538 Uncharacterized conserved protein [Function unknown]; Region: COG5476 398527021539 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 398527021540 MlrC C-terminus; Region: MlrC_C; pfam07171 398527021541 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527021542 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527021543 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 398527021544 dimerization interface [polypeptide binding]; other site 398527021545 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 398527021546 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 398527021547 active site 398527021548 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 398527021549 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 398527021550 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 398527021551 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 398527021552 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 398527021553 homotrimer interaction site [polypeptide binding]; other site 398527021554 putative active site [active] 398527021555 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 398527021556 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 398527021557 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 398527021558 Catalytic site [active] 398527021559 Phage protein Gp37/Gp68; Region: Gp37_Gp68; pfam07505 398527021560 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 398527021561 active site 398527021562 Zn binding site [ion binding]; other site 398527021563 Protein of unknown function (DUF3644); Region: DUF3644; pfam12358 398527021564 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 398527021565 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 398527021566 glutaminase active site [active] 398527021567 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 398527021568 dimer interface [polypeptide binding]; other site 398527021569 active site 398527021570 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 398527021571 dimer interface [polypeptide binding]; other site 398527021572 active site 398527021573 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 398527021574 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 398527021575 Substrate binding site; other site 398527021576 Mg++ binding site; other site 398527021577 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 398527021578 active site 398527021579 substrate binding site [chemical binding]; other site 398527021580 CoA binding site [chemical binding]; other site 398527021581 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 398527021582 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 398527021583 Ligand Binding Site [chemical binding]; other site 398527021584 Dihydroneopterin aldolase; Region: FolB; smart00905 398527021585 active site 398527021586 short chain dehydrogenase; Provisional; Region: PRK09134 398527021587 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 398527021588 NAD(P) binding site [chemical binding]; other site 398527021589 active site 398527021590 Uncharacterized conserved protein [Function unknown]; Region: COG1565 398527021591 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 398527021592 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 398527021593 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 398527021594 active site 398527021595 NTP binding site [chemical binding]; other site 398527021596 metal binding triad [ion binding]; metal-binding site 398527021597 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 398527021598 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 398527021599 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 398527021600 putative C-terminal domain interface [polypeptide binding]; other site 398527021601 putative GSH binding site (G-site) [chemical binding]; other site 398527021602 putative dimer interface [polypeptide binding]; other site 398527021603 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 398527021604 putative substrate binding pocket (H-site) [chemical binding]; other site 398527021605 putative N-terminal domain interface [polypeptide binding]; other site 398527021606 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 398527021607 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 398527021608 putative NAD(P) binding site [chemical binding]; other site 398527021609 active site 398527021610 lytic murein transglycosylase; Provisional; Region: PRK11619 398527021611 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 398527021612 N-acetyl-D-glucosamine binding site [chemical binding]; other site 398527021613 catalytic residue [active] 398527021614 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 398527021615 MarR family; Region: MarR_2; cl17246 398527021616 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 398527021617 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 398527021618 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 398527021619 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 398527021620 putative active site [active] 398527021621 Protein of unknown function (DUF969); Region: DUF969; pfam06149 398527021622 Predicted membrane protein [Function unknown]; Region: COG3817 398527021623 Protein of unknown function (DUF979); Region: DUF979; pfam06166 398527021624 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 398527021625 binding surface 398527021626 TPR motif; other site 398527021627 TPR repeat; Region: TPR_11; pfam13414 398527021628 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 398527021629 binding surface 398527021630 TPR motif; other site 398527021631 TPR repeat; Region: TPR_11; pfam13414 398527021632 TPR repeat; Region: TPR_11; pfam13414 398527021633 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 398527021634 binding surface 398527021635 TPR motif; other site 398527021636 TPR repeat; Region: TPR_11; pfam13414 398527021637 TPR repeat; Region: TPR_11; pfam13414 398527021638 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 398527021639 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 398527021640 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 398527021641 Protein of unknown function (DUF497); Region: DUF497; pfam04365 398527021642 TraB family; Region: TraB; pfam01963 398527021643 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 398527021644 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 398527021645 Walker A/P-loop; other site 398527021646 ATP binding site [chemical binding]; other site 398527021647 Q-loop/lid; other site 398527021648 ABC transporter signature motif; other site 398527021649 Walker B; other site 398527021650 D-loop; other site 398527021651 H-loop/switch region; other site 398527021652 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 398527021653 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 398527021654 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 398527021655 Walker A/P-loop; other site 398527021656 ATP binding site [chemical binding]; other site 398527021657 Q-loop/lid; other site 398527021658 ABC transporter signature motif; other site 398527021659 Walker B; other site 398527021660 D-loop; other site 398527021661 H-loop/switch region; other site 398527021662 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 398527021663 dipeptide transporter; Provisional; Region: PRK10913 398527021664 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527021665 dimer interface [polypeptide binding]; other site 398527021666 conserved gate region; other site 398527021667 putative PBP binding loops; other site 398527021668 ABC-ATPase subunit interface; other site 398527021669 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 398527021670 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 398527021671 dimer interface [polypeptide binding]; other site 398527021672 conserved gate region; other site 398527021673 putative PBP binding loops; other site 398527021674 ABC-ATPase subunit interface; other site 398527021675 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 398527021676 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 398527021677 peptide binding site [polypeptide binding]; other site 398527021678 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 398527021679 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 398527021680 peptide binding site [polypeptide binding]; other site 398527021681 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 398527021682 FAD binding site [chemical binding]; other site 398527021683 Membrane protein of unknown function; Region: DUF360; pfam04020 398527021684 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 398527021685 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 398527021686 homotetramer interface [polypeptide binding]; other site 398527021687 ligand binding site [chemical binding]; other site 398527021688 catalytic site [active] 398527021689 NAD binding site [chemical binding]; other site 398527021690 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 398527021691 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 398527021692 active site 398527021693 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527021694 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527021695 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 398527021696 putative dimerization interface [polypeptide binding]; other site 398527021697 Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078 398527021698 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 398527021699 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 398527021700 ligand binding site [chemical binding]; other site 398527021701 choline dehydrogenase; Validated; Region: PRK02106 398527021702 lycopene cyclase; Region: lycopene_cycl; TIGR01789 398527021703 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 398527021704 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 398527021705 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 398527021706 active site 398527021707 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 398527021708 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 398527021709 NAD(P) binding site [chemical binding]; other site 398527021710 catalytic residues [active] 398527021711 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 398527021712 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 398527021713 Flagellar protein FliT; Region: FliT; cl05125 398527021714 Flagellar protein FliT; Region: FliT; cl05125 398527021715 flagellar protein FliS; Validated; Region: fliS; PRK05685 398527021716 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 398527021717 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 398527021718 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 398527021719 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 398527021720 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 398527021721 FliG C-terminal domain; Region: FliG_C; pfam01706 398527021722 flagellar assembly protein H; Validated; Region: fliH; PRK05687 398527021723 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 398527021724 Flagellar assembly protein FliH; Region: FliH; pfam02108 398527021725 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 398527021726 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 398527021727 Walker A motif/ATP binding site; other site 398527021728 Walker B motif; other site 398527021729 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 398527021730 Flagellar FliJ protein; Region: FliJ; pfam02050 398527021731 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 398527021732 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 398527021733 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 398527021734 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 398527021735 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 398527021736 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 398527021737 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 398527021738 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 398527021739 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 398527021740 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 398527021741 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 398527021742 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06945 398527021743 Flagellar regulator YcgR; Region: YcgR; pfam07317 398527021744 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 398527021745 PilZ domain; Region: PilZ; pfam07238 398527021746 flagellar rod assembly protein/muramidase FlgJ; Provisional; Region: flgJ; PRK12709 398527021747 Rod binding protein; Region: Rod-binding; cl01626 398527021748 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 398527021749 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 398527021750 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 398527021751 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12697 398527021752 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 398527021753 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12694 398527021754 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 398527021755 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 398527021756 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 398527021757 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 398527021758 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 398527021759 flagellar hook protein FlgE; Provisional; Region: flgE; PRK12637 398527021760 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 398527021761 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 398527021762 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 398527021763 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 398527021764 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 398527021765 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 398527021766 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 398527021767 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 398527021768 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12626 398527021769 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 398527021770 SAF-like; Region: SAF_2; pfam13144 398527021771 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 398527021772 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 398527021773 FlgN protein; Region: FlgN; pfam05130 398527021774 YcfA-like protein; Region: YcfA; pfam07927 398527021775 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 398527021776 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 398527021777 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 398527021778 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 398527021779 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 398527021780 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 398527021781 DNA binding residues [nucleotide binding] 398527021782 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 398527021783 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 398527021784 flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14722 398527021785 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 398527021786 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 398527021787 FHIPEP family; Region: FHIPEP; pfam00771 398527021788 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 398527021789 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 398527021790 Protein of unknown function (DUF3443); Region: DUF3443; pfam11925 398527021791 Protein of unknown function (DUF2844); Region: DUF2844; pfam11005 398527021792 chemotaxis regulator CheZ; Provisional; Region: PRK11166 398527021793 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 398527021794 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527021795 active site 398527021796 phosphorylation site [posttranslational modification] 398527021797 intermolecular recognition site; other site 398527021798 dimerization interface [polypeptide binding]; other site 398527021799 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 398527021800 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527021801 active site 398527021802 phosphorylation site [posttranslational modification] 398527021803 intermolecular recognition site; other site 398527021804 dimerization interface [polypeptide binding]; other site 398527021805 CheB methylesterase; Region: CheB_methylest; pfam01339 398527021806 chemoreceptor glutamine deamidase CheD; Provisional; Region: PRK13489 398527021807 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 398527021808 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 398527021809 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 398527021810 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 398527021811 dimer interface [polypeptide binding]; other site 398527021812 ligand binding site [chemical binding]; other site 398527021813 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 398527021814 dimerization interface [polypeptide binding]; other site 398527021815 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 398527021816 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 398527021817 dimer interface [polypeptide binding]; other site 398527021818 putative CheW interface [polypeptide binding]; other site 398527021819 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 398527021820 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 398527021821 putative binding surface; other site 398527021822 active site 398527021823 CheY binding; Region: CheY-binding; pfam09078 398527021824 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 398527021825 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527021826 ATP binding site [chemical binding]; other site 398527021827 Mg2+ binding site [ion binding]; other site 398527021828 G-X-G motif; other site 398527021829 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 398527021830 Response regulator receiver domain; Region: Response_reg; pfam00072 398527021831 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527021832 active site 398527021833 phosphorylation site [posttranslational modification] 398527021834 intermolecular recognition site; other site 398527021835 dimerization interface [polypeptide binding]; other site 398527021836 flagellar motor protein MotB; Validated; Region: motB; PRK09041 398527021837 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 398527021838 ligand binding site [chemical binding]; other site 398527021839 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 398527021840 flagellar motor protein MotA; Validated; Region: PRK09110 398527021841 transcriptional activator FlhC; Provisional; Region: PRK12722 398527021842 transcriptional activator FlhD; Provisional; Region: PRK02909 398527021843 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 398527021844 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 398527021845 putative ADP-binding pocket [chemical binding]; other site 398527021846 H-NS histone family; Region: Histone_HNS; pfam00816 398527021847 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 398527021848 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 398527021849 amphipathic channel; other site 398527021850 Asn-Pro-Ala signature motifs; other site 398527021851 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 398527021852 putative hydrolase; Provisional; Region: PRK10976 398527021853 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 398527021854 active site 398527021855 motif I; other site 398527021856 motif II; other site 398527021857 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 398527021858 motif II; other site 398527021859 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 398527021860 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 398527021861 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 398527021862 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 398527021863 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 398527021864 active site 398527021865 catalytic tetrad [active] 398527021866 flagellin; Reviewed; Region: PRK08869 398527021867 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 398527021868 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 398527021869 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 398527021870 Flagellar protein FliT; Region: FliT; pfam05400 398527021871 TPR repeat; Region: TPR_11; pfam13414 398527021872 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 398527021873 TPR motif; other site 398527021874 binding surface 398527021875 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 398527021876 binding surface 398527021877 TPR motif; other site 398527021878 Tetratricopeptide repeat; Region: TPR_12; pfam13424 398527021879 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 398527021880 TPR motif; other site 398527021881 binding surface 398527021882 TPR repeat; Region: TPR_11; pfam13414 398527021883 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 398527021884 TPR motif; other site 398527021885 binding surface 398527021886 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 398527021887 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 398527021888 inhibitor-cofactor binding pocket; inhibition site 398527021889 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527021890 catalytic residue [active] 398527021891 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 398527021892 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 398527021893 dimer interface [polypeptide binding]; other site 398527021894 active site 398527021895 CoA binding pocket [chemical binding]; other site 398527021896 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 398527021897 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 398527021898 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 398527021899 dimer interface [polypeptide binding]; other site 398527021900 active site 398527021901 CoA binding pocket [chemical binding]; other site 398527021902 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 398527021903 classical (c) SDRs; Region: SDR_c; cd05233 398527021904 NAD(P) binding site [chemical binding]; other site 398527021905 active site 398527021906 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 398527021907 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 398527021908 putative trimer interface [polypeptide binding]; other site 398527021909 putative CoA binding site [chemical binding]; other site 398527021910 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 398527021911 [2Fe-2S] cluster binding site [ion binding]; other site 398527021912 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 398527021913 alpha subunit interface [polypeptide binding]; other site 398527021914 active site 398527021915 substrate binding site [chemical binding]; other site 398527021916 Fe binding site [ion binding]; other site 398527021917 Methyltransferase domain; Region: Methyltransf_24; pfam13578 398527021918 Methyltransferase domain; Region: Methyltransf_23; pfam13489 398527021919 Methyltransferase domain; Region: Methyltransf_11; pfam08241 398527021920 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 398527021921 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 398527021922 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 398527021923 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 398527021924 motif II; other site 398527021925 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 398527021926 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 398527021927 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 398527021928 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 398527021929 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 398527021930 non-specific DNA binding site [nucleotide binding]; other site 398527021931 salt bridge; other site 398527021932 sequence-specific DNA binding site [nucleotide binding]; other site 398527021933 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527021934 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 398527021935 Walker A motif; other site 398527021936 ATP binding site [chemical binding]; other site 398527021937 Walker B motif; other site 398527021938 arginine finger; other site 398527021939 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 398527021940 active site 398527021941 catalytic triad [active] 398527021942 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 398527021943 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 398527021944 Integrase core domain; Region: rve; pfam00665 398527021945 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 398527021946 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 398527021947 Walker A motif; other site 398527021948 ATP binding site [chemical binding]; other site 398527021949 Walker B motif; other site 398527021950 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 398527021951 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 398527021952 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 398527021953 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 398527021954 Integrase core domain; Region: rve; pfam00665 398527021955 AAA domain; Region: AAA_22; pfam13401 398527021956 AAA domain; Region: AAA_17; pfam13207 398527021957 TniQ; Region: TniQ; pfam06527 398527021958 Cytochrome c; Region: Cytochrom_C; cl11414 398527021959 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 398527021960 Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245 398527021961 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 398527021962 Part of AAA domain; Region: AAA_19; pfam13245 398527021963 Family description; Region: UvrD_C_2; pfam13538 398527021964 putative oxidoreductase; Provisional; Region: PRK11579 398527021965 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 398527021966 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 398527021967 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 398527021968 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 398527021969 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 398527021970 lipoyl attachment site [posttranslational modification]; other site 398527021971 glycine dehydrogenase; Provisional; Region: PRK05367 398527021972 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 398527021973 tetramer interface [polypeptide binding]; other site 398527021974 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527021975 catalytic residue [active] 398527021976 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 398527021977 tetramer interface [polypeptide binding]; other site 398527021978 pyridoxal 5'-phosphate binding site [chemical binding]; other site 398527021979 catalytic residue [active] 398527021980 Alginate lyase; Region: Alginate_lyase; pfam05426 398527021981 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 398527021982 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 398527021983 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 398527021984 thiamine pyrophosphate protein; Validated; Region: PRK08199 398527021985 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 398527021986 PYR/PP interface [polypeptide binding]; other site 398527021987 dimer interface [polypeptide binding]; other site 398527021988 TPP binding site [chemical binding]; other site 398527021989 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 398527021990 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 398527021991 TPP-binding site [chemical binding]; other site 398527021992 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 398527021993 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 398527021994 dimerization interface [polypeptide binding]; other site 398527021995 ligand binding site [chemical binding]; other site 398527021996 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 398527021997 Predicted transcriptional regulator [Transcription]; Region: COG3905 398527021998 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 398527021999 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 398527022000 Glutamate binding site [chemical binding]; other site 398527022001 NAD binding site [chemical binding]; other site 398527022002 catalytic residues [active] 398527022003 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 398527022004 NAD(P) binding site [chemical binding]; other site 398527022005 primosome assembly protein PriA; Validated; Region: PRK05580 398527022006 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 398527022007 ATP binding site [chemical binding]; other site 398527022008 putative Mg++ binding site [ion binding]; other site 398527022009 helicase superfamily c-terminal domain; Region: HELICc; smart00490 398527022010 ATP-binding site [chemical binding]; other site 398527022011 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 398527022012 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 398527022013 substrate binding site [chemical binding]; other site 398527022014 active site 398527022015 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 398527022016 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 398527022017 substrate binding pocket [chemical binding]; other site 398527022018 membrane-bound complex binding site; other site 398527022019 hinge residues; other site 398527022020 AMP-binding domain protein; Validated; Region: PRK08315 398527022021 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 398527022022 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 398527022023 acyl-activating enzyme (AAE) consensus motif; other site 398527022024 putative AMP binding site [chemical binding]; other site 398527022025 putative active site [active] 398527022026 putative CoA binding site [chemical binding]; other site 398527022027 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 398527022028 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 398527022029 gamma subunit interface [polypeptide binding]; other site 398527022030 epsilon subunit interface [polypeptide binding]; other site 398527022031 LBP interface [polypeptide binding]; other site 398527022032 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 398527022033 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 398527022034 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 398527022035 alpha subunit interaction interface [polypeptide binding]; other site 398527022036 Walker A motif; other site 398527022037 ATP binding site [chemical binding]; other site 398527022038 Walker B motif; other site 398527022039 inhibitor binding site; inhibition site 398527022040 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 398527022041 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 398527022042 core domain interface [polypeptide binding]; other site 398527022043 delta subunit interface [polypeptide binding]; other site 398527022044 epsilon subunit interface [polypeptide binding]; other site 398527022045 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 398527022046 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 398527022047 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 398527022048 beta subunit interaction interface [polypeptide binding]; other site 398527022049 Walker A motif; other site 398527022050 ATP binding site [chemical binding]; other site 398527022051 Walker B motif; other site 398527022052 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 398527022053 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 398527022054 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 398527022055 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 398527022056 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 398527022057 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 398527022058 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 398527022059 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 398527022060 ATP synthase I chain; Region: ATP_synt_I; cl09170 398527022061 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 398527022062 ParB-like nuclease domain; Region: ParBc; pfam02195 398527022063 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 398527022064 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 398527022065 P-loop; other site 398527022066 Magnesium ion binding site [ion binding]; other site 398527022067 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 398527022068 Magnesium ion binding site [ion binding]; other site 398527022069 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 398527022070 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 398527022071 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 398527022072 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 398527022073 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 398527022074 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 398527022075 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 398527022076 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 398527022077 Walker A/P-loop; other site 398527022078 ATP binding site [chemical binding]; other site 398527022079 Q-loop/lid; other site 398527022080 ABC transporter signature motif; other site 398527022081 Walker B; other site 398527022082 D-loop; other site 398527022083 H-loop/switch region; other site 398527022084 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 398527022085 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 398527022086 TM-ABC transporter signature motif; other site 398527022087 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 398527022088 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 398527022089 Walker A/P-loop; other site 398527022090 ATP binding site [chemical binding]; other site 398527022091 Q-loop/lid; other site 398527022092 ABC transporter signature motif; other site 398527022093 Walker B; other site 398527022094 D-loop; other site 398527022095 H-loop/switch region; other site 398527022096 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 398527022097 TM-ABC transporter signature motif; other site 398527022098 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 398527022099 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 398527022100 putative ligand binding site [chemical binding]; other site 398527022101 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 398527022102 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 398527022103 putative ligand binding site [chemical binding]; other site 398527022104 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 398527022105 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 398527022106 TM-ABC transporter signature motif; other site 398527022107 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 398527022108 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 398527022109 TM-ABC transporter signature motif; other site 398527022110 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 398527022111 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 398527022112 putative ligand binding site [chemical binding]; other site 398527022113 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 398527022114 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 398527022115 Walker A/P-loop; other site 398527022116 ATP binding site [chemical binding]; other site 398527022117 Q-loop/lid; other site 398527022118 ABC transporter signature motif; other site 398527022119 Walker B; other site 398527022120 D-loop; other site 398527022121 H-loop/switch region; other site 398527022122 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 398527022123 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 398527022124 Walker A/P-loop; other site 398527022125 ATP binding site [chemical binding]; other site 398527022126 Q-loop/lid; other site 398527022127 ABC transporter signature motif; other site 398527022128 Walker B; other site 398527022129 D-loop; other site 398527022130 H-loop/switch region; other site 398527022131 choline dehydrogenase; Validated; Region: PRK02106 398527022132 lycopene cyclase; Region: lycopene_cycl; TIGR01789 398527022133 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 398527022134 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 398527022135 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 398527022136 tetrameric interface [polypeptide binding]; other site 398527022137 NAD binding site [chemical binding]; other site 398527022138 catalytic residues [active] 398527022139 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527022140 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527022141 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 398527022142 dimerization interface [polypeptide binding]; other site 398527022143 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 398527022144 putative active site [active] 398527022145 putative metal binding residues [ion binding]; other site 398527022146 signature motif; other site 398527022147 putative triphosphate binding site [ion binding]; other site 398527022148 dimer interface [polypeptide binding]; other site 398527022149 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 398527022150 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 398527022151 putative DNA binding site [nucleotide binding]; other site 398527022152 putative Zn2+ binding site [ion binding]; other site 398527022153 AsnC family; Region: AsnC_trans_reg; pfam01037 398527022154 Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348 398527022155 cofactor binding site; other site 398527022156 metal binding site [ion binding]; metal-binding site 398527022157 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 398527022158 aromatic arch; other site 398527022159 DCoH dimer interaction site [polypeptide binding]; other site 398527022160 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 398527022161 DCoH tetramer interaction site [polypeptide binding]; other site 398527022162 substrate binding site [chemical binding]; other site 398527022163 Protein of unknown function (DUF3717); Region: DUF3717; pfam12512 398527022164 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 398527022165 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527022166 active site 398527022167 phosphorylation site [posttranslational modification] 398527022168 intermolecular recognition site; other site 398527022169 dimerization interface [polypeptide binding]; other site 398527022170 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 398527022171 DNA binding site [nucleotide binding] 398527022172 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 398527022173 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 398527022174 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 398527022175 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 398527022176 dimer interface [polypeptide binding]; other site 398527022177 phosphorylation site [posttranslational modification] 398527022178 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527022179 ATP binding site [chemical binding]; other site 398527022180 Mg2+ binding site [ion binding]; other site 398527022181 G-X-G motif; other site 398527022182 Proteins containing SET domain [General function prediction only]; Region: COG2940 398527022183 SET domain; Region: SET; pfam00856 398527022184 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 398527022185 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 398527022186 active site 398527022187 FMN binding site [chemical binding]; other site 398527022188 substrate binding site [chemical binding]; other site 398527022189 homotetramer interface [polypeptide binding]; other site 398527022190 catalytic residue [active] 398527022191 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 398527022192 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 398527022193 catalytic triad [active] 398527022194 Transcriptional regulators [Transcription]; Region: MarR; COG1846 398527022195 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 398527022196 putative DNA binding site [nucleotide binding]; other site 398527022197 putative Zn2+ binding site [ion binding]; other site 398527022198 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 398527022199 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 398527022200 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 398527022201 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 398527022202 Uncharacterized conserved protein [Function unknown]; Region: COG4121 398527022203 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 398527022204 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 398527022205 IHF dimer interface [polypeptide binding]; other site 398527022206 IHF - DNA interface [nucleotide binding]; other site 398527022207 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 398527022208 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 398527022209 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 398527022210 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 398527022211 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 398527022212 N-acetyl-D-glucosamine binding site [chemical binding]; other site 398527022213 catalytic residue [active] 398527022214 type II secretion system protein D; Region: type_II_gspD; TIGR02517 398527022215 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 398527022216 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 398527022217 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 398527022218 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 398527022219 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 398527022220 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 398527022221 type II secretion system protein E; Region: type_II_gspE; TIGR02533 398527022222 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 398527022223 Walker A motif; other site 398527022224 ATP binding site [chemical binding]; other site 398527022225 Walker B motif; other site 398527022226 type II secretion system protein F; Region: GspF; TIGR02120 398527022227 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 398527022228 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 398527022229 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 398527022230 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 398527022231 type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708 398527022232 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 398527022233 Type II transport protein GspH; Region: GspH; pfam12019 398527022234 type II secretion system protein I; Region: gspI; TIGR01707 398527022235 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 398527022236 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 398527022237 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 398527022238 GspL periplasmic domain; Region: GspL_C; pfam12693 398527022239 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 398527022240 Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203 398527022241 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 398527022242 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 398527022243 MarR family; Region: MarR_2; cl17246 398527022244 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 398527022245 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 398527022246 putative substrate translocation pore; other site 398527022247 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14959 398527022248 glutamate--cysteine ligase; Provisional; Region: PRK02107 398527022249 AlkA N-terminal domain; Region: AlkA_N; pfam06029 398527022250 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 398527022251 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 398527022252 minor groove reading motif; other site 398527022253 helix-hairpin-helix signature motif; other site 398527022254 substrate binding pocket [chemical binding]; other site 398527022255 active site 398527022256 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 398527022257 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 398527022258 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 398527022259 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 398527022260 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 398527022261 DNA binding site [nucleotide binding] 398527022262 active site 398527022263 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 398527022264 dimer interface [polypeptide binding]; other site 398527022265 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 398527022266 metal binding site [ion binding]; metal-binding site 398527022267 YaeQ protein; Region: YaeQ; pfam07152 398527022268 Transcriptional regulator [Transcription]; Region: LysR; COG0583 398527022269 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 398527022270 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 398527022271 putative dimerization interface [polypeptide binding]; other site 398527022272 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 398527022273 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 398527022274 NAD(P) binding site [chemical binding]; other site 398527022275 catalytic residues [active] 398527022276 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 398527022277 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 398527022278 ligand binding site [chemical binding]; other site 398527022279 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 398527022280 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 398527022281 Walker A/P-loop; other site 398527022282 ATP binding site [chemical binding]; other site 398527022283 Q-loop/lid; other site 398527022284 ABC transporter signature motif; other site 398527022285 Walker B; other site 398527022286 D-loop; other site 398527022287 H-loop/switch region; other site 398527022288 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 398527022289 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 398527022290 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 398527022291 TM-ABC transporter signature motif; other site 398527022292 dihydroxy-acid dehydratase; Validated; Region: PRK06131 398527022293 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 398527022294 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 398527022295 Coenzyme A binding pocket [chemical binding]; other site 398527022296 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 398527022297 HIT family signature motif; other site 398527022298 catalytic residue [active] 398527022299 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 398527022300 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 398527022301 conserved cys residue [active] 398527022302 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 398527022303 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 398527022304 NAD(P) binding site [chemical binding]; other site 398527022305 active site 398527022306 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 398527022307 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 398527022308 putative DNA binding site [nucleotide binding]; other site 398527022309 putative Zn2+ binding site [ion binding]; other site 398527022310 AsnC family; Region: AsnC_trans_reg; pfam01037 398527022311 2-oxoacid dehydrogenase subunit E1; Provisional; Region: PRK13012 398527022312 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 398527022313 dimer interface [polypeptide binding]; other site 398527022314 TPP-binding site [chemical binding]; other site 398527022315 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 398527022316 Response regulator receiver domain; Region: Response_reg; pfam00072 398527022317 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527022318 active site 398527022319 phosphorylation site [posttranslational modification] 398527022320 intermolecular recognition site; other site 398527022321 dimerization interface [polypeptide binding]; other site 398527022322 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 398527022323 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 398527022324 metal binding site [ion binding]; metal-binding site 398527022325 active site 398527022326 I-site; other site 398527022327 chemotaxis-specific methylesterase; Provisional; Region: PRK12555 398527022328 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527022329 phosphorylation site [posttranslational modification] 398527022330 intermolecular recognition site; other site 398527022331 CheB methylesterase; Region: CheB_methylest; pfam01339 398527022332 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 398527022333 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 398527022334 putative binding surface; other site 398527022335 active site 398527022336 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 398527022337 ATP binding site [chemical binding]; other site 398527022338 Mg2+ binding site [ion binding]; other site 398527022339 G-X-G motif; other site 398527022340 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 398527022341 Response regulator receiver domain; Region: Response_reg; pfam00072 398527022342 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 398527022343 active site 398527022344 phosphorylation site [posttranslational modification] 398527022345 intermolecular recognition site; other site 398527022346 dimerization interface [polypeptide binding]; other site 398527022347 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 398527022348 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 398527022349 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 398527022350 S-adenosylmethionine binding site [chemical binding]; other site 398527022351 Tetratricopeptide repeat; Region: TPR_16; pfam13432 398527022352 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 398527022353 TPR motif; other site 398527022354 binding surface 398527022355 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 398527022356 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 398527022357 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 398527022358 dimerization interface [polypeptide binding]; other site 398527022359 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 398527022360 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 398527022361 dimer interface [polypeptide binding]; other site 398527022362 putative CheW interface [polypeptide binding]; other site 398527022363 integrase; Provisional; Region: PRK09692 398527022364 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 398527022365 active site 398527022366 Int/Topo IB signature motif; other site 398527022367 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 398527022368 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 398527022369 trmE is a tRNA modification GTPase; Region: trmE; cd04164 398527022370 G1 box; other site 398527022371 GTP/Mg2+ binding site [chemical binding]; other site 398527022372 Switch I region; other site 398527022373 G2 box; other site 398527022374 Switch II region; other site 398527022375 G3 box; other site 398527022376 G4 box; other site 398527022377 G5 box; other site 398527022378 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 398527022379 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 398527022380 sequence-specific DNA binding site [nucleotide binding]; other site 398527022381 salt bridge; other site 398527022382 membrane protein insertase; Provisional; Region: PRK01318 398527022383 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 398527022384 hypothetical protein; Validated; Region: PRK00041 398527022385 Ribonuclease P; Region: Ribonuclease_P; cl00457 398527022386 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399